MCC
MCID: MRK001
MIFTS: 66

Merkel Cell Carcinoma (MCC)

Categories: Cancer diseases, Endocrine diseases, Immune diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Merkel Cell Carcinoma

MalaCards integrated aliases for Merkel Cell Carcinoma:

Name: Merkel Cell Carcinoma 12 52 58 36 15 71
Trabecular Adenocarcinoma 12 6 71
Cutaneous Neuroendocrine Carcinoma 52 58
Carcinoma, Merkel Cell 52
Carcinoma Merkel Cell 54
Trabecular Carcinoma 12
Merkel Cell Cancer 52
Merkle Tumors 52
Mcc 58

Characteristics:

Orphanet epidemiological data:

58
cutaneous neuroendocrine carcinoma
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/1000000 (Europe),1-9/100000 (Australia); Age of onset: Adult; Age of death: elderly;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:3965
KEGG 36 H01555
NCIt 49 C4068
SNOMED-CT 67 29792007
ICD10 via Orphanet 33 C44.3 C44.6 C44.7
UMLS via Orphanet 72 C0007129
Orphanet 58 ORPHA79140
UMLS 71 C0007129 C0302182

Summaries for Merkel Cell Carcinoma

KEGG : 36 Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignancy that exhibits clinically aggressive features and is associated with a poor prognosis. Ultraviolet (UV) radiation may be a cause, and corresponds with the sites of these tumours, often on sun-exposed skin, mostly (94%) in the White population. UV light may exert local immunomodulating action as it decreases amount of epidermal T cells and Langerhans cells, inducing hapten tolerance. Additionally, UV- specific mutations in TP53 and Harvey (Ha)-RAS genes are present in some MCC cell lines. Recently, the polyomavirus group has been linked with MCC. The MCC polyomavirus (MCPyV) has been isolated from MCC tissue and thought to be present in up to 80% of MCC. Tumorigenesis likely is caused by a number of sequential steps from viral integration into host DNA, mutagenic events, and specific immune responses.

MalaCards based summary : Merkel Cell Carcinoma, also known as trabecular adenocarcinoma, is related to eyelid carcinoma and neuroendocrine tumor. An important gene associated with Merkel Cell Carcinoma is KRT20 (Keratin 20), and among its related pathways/superpathways are Neuroscience and NF-kappaB Signaling. The drugs Bleomycin and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are merkel cell skin cancer and cutaneous photosensitivity

NIH Rare Diseases : 52 Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer . It usually develops as a single, painless, bump on sun-exposed skin. The bump may be skin-colored or red-violet, and tends to grow rapidly over weeks to months. It may spread quickly to surrounding tissues , nearby lymph nodes , or more distant parts of the body. Factors associated with developing MCC include increasing age, fair skin, a history of extensive sun exposure, chronic immune suppression, and the Merkel cell polyomavirus. This virus has been detected in about 80% of people with MCC. Treatment may include surgery, radiation therapy , and/or chemotherapy . Treatment options and prognosis depend on the location(s) and size of the cancer , whether it has just been diagnosed or has come back (recurred), and how deeply it has grown into the skin.

Wikipedia : 74 Merkel-cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about 3 per 1,000,000... more...

Related Diseases for Merkel Cell Carcinoma

Diseases related to Merkel Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 741)
# Related Disease Score Top Affiliating Genes
1 eyelid carcinoma 32.0 KRT7 KRT20
2 neuroendocrine tumor 31.6 SYP SST NKX2-1 NCAM1 KRT20 ENO2
3 skin carcinoma 31.6 TP53 KRT8 KRT7 KRT20 CHGA CD274
4 lung oat cell carcinoma 31.4 SYP ENO2 CHGA
5 in situ carcinoma 31.1 TP53 MUC1 KRT8
6 ganglioneuroblastoma 31.0 TP53 SYP ENO2
7 basal cell carcinoma 30.9 TP53 SYP NCAM1 KRT8 KRT7 KRT20
8 leukemia, chronic lymphocytic 30.8 TP53 PTPRC PAX5 NCAM1 KIT CD274
9 lymphoblastic lymphoma 30.8 TP53 PTPRC PAX5
10 eyelid benign neoplasm 30.8 KRT20 CHGA
11 rhabdomyosarcoma 2 30.7 TP53 SYP ENO2
12 b-cell lymphoma 30.7 TP53 RB1 PTPRC PAX5 CD274
13 paget disease, extramammary 30.7 MUC1 KRT7 KRT20
14 neuroendocrine carcinoma 30.7 SYP SST PTPRC PAX5 NKX2-1 NCAM1
15 malignant syringoma 30.6 KRT7 KRT20
16 cll/sll 30.6 TP53 PDCD1 PAX5
17 dermatofibrosarcoma protuberans 30.6 TP53 KIT ENO2
18 somatostatinoma 30.6 SST ENO2 CHGA
19 neurilemmoma 30.6 MUC1 KIT ENO2
20 sweat gland cancer 30.6 TP53 SYP KRT8 KRT7 KRT20
21 dendritic cell tumor 30.6 PTPRC MUC1 KRT20
22 neurofibroma 30.5 TP53 SYP MUC1 KIT
23 thyroid carcinoma, familial medullary 30.5 SST NKX2-1 CHGA
24 adenoma 30.5 TP53 SST MUC1 KRT7 CHGA
25 carcinosarcoma 30.5 TP53 MUC1 KRT7 KIT
26 pancytopenia 30.5 TP53 PTPRC NCAM1 KIT
27 pleomorphic adenoma 30.4 TP53 MUC1 KRT7
28 carcinoid tumors, intestinal 30.4 SYP SST NKX2-1 ENO2 CHGA
29 ewing sarcoma 30.3 TP53 SYP PTPRC NCAM1 KIT ENO2
30 rhabdomyosarcoma 30.3 TP53 SYP RB1 PTPRC KIT ENO2
31 adenocarcinoma 30.3 TP53 RB1 NKX2-1 MUC1 KRT7 KRT20
32 meningioma, familial 30.3 TP53 SYP SST KIT ENO2
33 thyroid gland medullary carcinoma 30.3 SYP SST KDR ENO2 CHGA
34 sarcoma 30.2 TP53 RB1 PTPRC MUC1 KIT KDR
35 mammary paget's disease 30.2 MUC1 KRT8 KRT7 KRT20 CD274
36 lymphoma 30.2 TP53 RB1 PTPRC PDCD1 PAX5 KIT
37 papillary carcinoma 30.2 SYP NKX2-1 MUC1 KRT7 KRT20 CHGA
38 sarcoma, synovial 30.2 MUC1 KRT8 KRT7 KIT
39 spindle cell carcinoma 30.2 SYP MUC1 KRT8 KRT7 ENO2 CHGA
40 wilms tumor 1 30.2 TP53 SYP NCAM1 KRT7 KIT ENO2
41 paraganglioma 30.2 SYP SST NCAM1 KIT ENO2 CHGA
42 keratinizing squamous cell carcinoma 30.1 TP53 SYP NKX2-1 KRT8 KRT7
43 small cell carcinoma 30.1 TP53 SYP PTPRC NKX2-1 NCAM1 MUC1
44 angiosarcoma 30.0 TP53 MUC1 KRT8 KRT7 KIT KDR
45 exanthem 30.0 PDCD1 KIT KDR CD274
46 hemangioma 30.0 TP53 SYP NKX2-1 MUC1 KRT7 KIT
47 pancreatic adenocarcinoma 30.0 TP53 SST MUC1 KIT KDR CHGA
48 large cell neuroendocrine carcinoma 29.9 SYP NKX2-1 NCAM1 KRT7 KRT20 KIT
49 pheochromocytoma 29.9 SYP SST NCAM1 KRT7 KIT KDR
50 lung benign neoplasm 29.9 TP53 SYP RB1 NKX2-1 NCAM1 KRT7

Graphical network of the top 20 diseases related to Merkel Cell Carcinoma:



Diseases related to Merkel Cell Carcinoma

Symptoms & Phenotypes for Merkel Cell Carcinoma

Human phenotypes related to Merkel Cell Carcinoma:

58 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 merkel cell skin cancer 58 31 obligate (100%) Obligate (100%) HP:0030447
2 cutaneous photosensitivity 58 31 frequent (33%) Frequent (79-30%) HP:0000992
3 cellular immunodeficiency 58 31 frequent (33%) Frequent (79-30%) HP:0005374
4 skin nodule 58 31 frequent (33%) Frequent (79-30%) HP:0200036
5 erythematous macule 58 31 frequent (33%) Frequent (79-30%) HP:0025475
6 regional abnormality of skin 58 31 frequent (33%) Frequent (79-30%) HP:0011356
7 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
8 erythematous plaque 58 31 frequent (33%) Frequent (79-30%) HP:0025474
9 carcinoid tumor 58 31 occasional (7.5%) Occasional (29-5%) HP:0100570
10 basal cell carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0002671
11 squamous cell carcinoma of the skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0006739
12 multiple myeloma 58 31 occasional (7.5%) Occasional (29-5%) HP:0006775
13 lymphoid leukemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0005526
14 abnormal brain fdg positron emission tomography 58 31 very rare (1%) Very rare (<4-1%) HP:0012658
15 brain neoplasm 58 31 very rare (1%) Very rare (<4-1%) HP:0030692
16 neoplasm of the outer ear 58 31 very rare (1%) Very rare (<4-1%) HP:0040095
17 pain 58 Excluded (0%)

GenomeRNAi Phenotypes related to Merkel Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ATOH1 CHGA KIT KRT7 MAP2 NKX2-1

MGI Mouse Phenotypes related to Merkel Cell Carcinoma:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 ATOH1 CD274 ENO2 KDR KIT MAP2
2 cellular MP:0005384 10.34 ATOH1 CD274 ENO2 KDR KIT KRT7
3 growth/size/body region MP:0005378 10.29 CHGA ENO2 KDR KIT KRT8 MAP2
4 homeostasis/metabolism MP:0005376 10.28 ATOH1 CD274 CHGA KDR KIT KRT7
5 mortality/aging MP:0010768 10.28 ATOH1 CD274 CHGA KDR KIT KRT8
6 cardiovascular system MP:0005385 10.24 CHGA KDR KIT KRT8 NKX2-1 PAX5
7 nervous system MP:0003631 10.2 ATOH1 CHGA ENO2 KDR KIT MAP2
8 endocrine/exocrine gland MP:0005379 10.15 ATOH1 CHGA KIT MAP2 NKX2-1 PDCD1
9 digestive/alimentary MP:0005381 10.11 ATOH1 KIT KRT8 NKX2-1 PTPRC RB1
10 no phenotypic analysis MP:0003012 9.96 ATOH1 CD274 CHGA KDR KIT NKX2-1
11 hearing/vestibular/ear MP:0005377 9.93 ATOH1 KIT KRT8 PAX5 RB1 TP53
12 neoplasm MP:0002006 9.91 KIT NKX2-1 PAX5 PDCD1 PTPRC RB1
13 normal MP:0002873 9.85 ATOH1 KDR KIT NKX2-1 PAX5 PTPRC
14 respiratory system MP:0005388 9.61 ATOH1 ENO2 KDR KIT NKX2-1 PDCD1
15 skeleton MP:0005390 9.32 CD274 KDR KIT NKX2-1 PAX5 PDCD1

Drugs & Therapeutics for Merkel Cell Carcinoma

Drugs for Merkel Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 4 11056-06-7 5360373
2 Antibiotics, Antitubercular Phase 4
3 Anti-Bacterial Agents Phase 4
4
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
5
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
6
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
7
lanreotide Approved Phase 2 108736-35-2
8
Durvalumab Approved, Investigational Phase 1, Phase 2 1428935-60-7
9
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
10 Daratumumab Approved Phase 1, Phase 2 945721-28-8
11
Etoposide Approved Phase 2 33419-42-0 36462
12
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
13
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
14
Atezolizumab Approved, Investigational Phase 1, Phase 2 1380723-44-3
15
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
16
nivolumab Approved Phase 2 946414-94-4
17
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
18
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
19
Oblimersen Experimental, Investigational Phase 2 190977-41-4
20
Mitoguazone Investigational Phase 2 459-86-9
21
Tremelimumab Investigational Phase 1, Phase 2 745013-59-6
22 Protein Kinase Inhibitors Phase 2
23 Imatinib Mesylate Phase 2 220127-57-1 123596
24 Folic Acid Antagonists Phase 2
25 Vitamin B9 Phase 2
26 Vitamin B Complex Phase 2
27 Folate Phase 2
28 Interleukin-12 Phase 2
29 topoisomerase I inhibitors Phase 2
30 Angiopeptin Phase 2
31 Immunoglobulin G Phase 2
32 Cathartics Phase 1, Phase 2
33 Gastrointestinal Agents Phase 1, Phase 2
34 Poly ICLC Phase 1, Phase 2
35 Laxatives Phase 1, Phase 2
36 Poly I-C Phase 1, Phase 2
37 Interferon Inducers Phase 1, Phase 2
38 Carboxymethylcellulose Sodium Phase 1, Phase 2
39 Endothelial Growth Factors Phase 2
40 Mitogens Phase 2
41 Antibodies, Blocking Phase 2
42 Etoposide phosphate Phase 2
43 Topoisomerase Inhibitors Phase 2
44 glucocorticoids Phase 1, Phase 2
45 interferons Phase 1, Phase 2
46 Anti-Infective Agents Phase 1, Phase 2
47 Antiviral Agents Phase 1, Phase 2
48 Interleukin-2 Phase 1, Phase 2
49 Analgesics, Non-Narcotic Phase 1, Phase 2
50 Anti-Retroviral Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 An Open-Label Study Using the MedPulser Electroporation System to Treat Cutaneous and Subcutaneous Foci of Cancer Completed NCT00198276 Phase 4
2 STAMP: Surgically Treated Adjuvant Merkel Cell Carcinoma With Pembrolizumab, a Phase III Trial Recruiting NCT03712605 Phase 3
3 A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial of Adjuvant Avelumab (Anti-PDL-1 Antibody) in Merkel Cell Carcinoma Patients With Clinically Detected Lymph Node Metastases Recruiting NCT03271372 Phase 3 Avelumab
4 A Phase 3 Open-label, Single Arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) as First Line Therapy in Participants With Advanced Merkel Cell Carcinoma (KEYNOTE-913) Recruiting NCT03783078 Phase 3 Pembrolizumab (MK-3475)
5 A Phase II Trial of STI-571/Imatinib (Gleevec®) (NSC-716051) in Neuroendocrine Carcinoma of the Skin (Merkel Cell Carcinoma) Completed NCT00068783 Phase 2 imatinib mesylate
6 A Phase II Study of G3139 (Genasense ™) in Patients With Merkel Cell Carcinoma Completed NCT00079131 Phase 2
7 A Phase II Trial of Cyclophosphamide, Methotrexate and 5-Fluorouracil (CMF) in Neuroendocrine Carcinoma of the Skin (Merkel Cell Carcinoma) Completed NCT00003549 Phase 2 CMF regimen;cyclophosphamide;fluorouracil;methotrexate
8 A Phase II Study of Intratumoral Injection of Interleukin-12 Plasmid and in Vivo Electroporation in Patients With Merkel Cell Carcinoma Completed NCT01440816 Phase 2
9 A Phase II Clinical Trial of Irinotecan (CPT-11) in Patients With Advanced High Grade Neuroendocrine Tumors Completed NCT00004922 Phase 2 irinotecan hydrochloride
10 Traitement Des Carcinomes à Cellules de Merkel inopérables et/ou métastatiques Par Analogue de la Somatostatine - Etude Nationale Multicentrique Mono-bras de Phase II. Completed NCT02351128 Phase 2 Lanreotide
11 A Phase 2 Study of INCMGA00012 in Participants With Metastatic Merkel Cell Carcinoma (POD1UM-201) Recruiting NCT03599713 Phase 2 INCMGA00012
12 A Phase II Randomized Trial of Intralesional Talimogene Laherparepvec (TALIMOGENE LAHERPAREPVEC) With or Without Radiotherapy for Cutaneous Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors Recruiting NCT02819843 Phase 2 TALIMOGENE LAHERPAREPVEC (TVEC)
13 A Phase 2, Open-Label, Study of KRT-232 in Patients With p53 Wild-Type (p53WT) Merkel Cell Carcinoma (MCC) Who Have Failed Anti-PD-1 or Anti-PD-L1 Immunotherapy Recruiting NCT03787602 Phase 2 KRT-232
14 A Phase 2, Randomized, Multi-institutional Study of Nivolumab and Ipilimumab Versus Nivolumab, Ipilimumab and Stereotactic Body Radiation Therapy for Metastatic Merkel Cell Carcinoma Recruiting NCT03071406 Phase 2 Nivolumab;Ipilimumab
15 A Randomized Phase II Study of Anti-PD1 Antibody [MK-3475 (Pembrolizumab)] Alone Versus Anti-PD1 Antibody Plus Stereotactic Body Radiation Therapy in Advanced Merkel Cell Carcinoma Recruiting NCT03304639 Phase 2
16 A Phase II Study of Palliative Radiation Therapy and Anti-PD-1/PD-L1 Checkpoint Blockade in Patients With Metastatic Merkel Cell Carcinoma Recruiting NCT03988647 Phase 2 Pembrolizumab
17 A Phase 1/2 Study of In Situ Vaccination With Tremelimumab and IV Durvalumab (MEDI4736) Plus the Toll-like Receptor Agonist PolyICLC in Subjects With Advanced, Measurable, Biopsy-accessible Cancers Recruiting NCT02643303 Phase 1, Phase 2 Durvalumab;Tremelimumab;Poly ICLC
18 A Phase II, Single-Arm Open-Label Study of the Combination of Atezolizumab and Bevacizumab in Rare Solid Tumors Recruiting NCT03074513 Phase 2 Atezolizumab
19 Phase I/II Study of Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity MCPyV-Specific TCRs Combined With Avelumab and Class I MHC-Upregulation in Patients With Metastatic MCC Refractory to PD-1 Axis Blockade Recruiting NCT03747484 Phase 1, Phase 2 Avelumab
20 Prospective Randomized Trial of an Adjuvant Therapy of Completely Resected Merkel Cell Carcinoma (MCC) With Immune Checkpoint Blocking Antibodies (Nivolumab, Opdivo®; Ipilimumab (Yervoy®) Every 3 Weeks for 12 Weeks Versus Observation Recruiting NCT02196961 Phase 2 Nivolumab
21 A Phase 1b/2 Study of AST-008 Combined With Pembrolizumab in Patients With Advanced Solid Tumors Recruiting NCT03684785 Phase 1, Phase 2 AST-008
22 A Phase 1/2, Open-label, Multicenter, Dose Escalation and Dose Expansion Study of NKTR-262 in Combination With NKTR-214 and in Combination With NKTR-214 Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies Recruiting NCT03435640 Phase 1, Phase 2 NKTR-262;bempegaldesleukin;nivolumab
23 QUILT-3.055: A Phase IIb, Single-Arm, Multicohort, Open-Label Study of ALT-803 in Combination With PD-1/PD-L1 Checkpoint Inhibitor in Patients Who Have Disease Progression Following an Initial Response to Treatment With PD-1/PD-L1 Checkpoint Inhibitor Therapy Recruiting NCT03228667 Phase 2 ALT-803 + Pembrolizumab;ALT-803 + Nivolumab;ALT-803 + Atezolizumab;ALT-803 + Avelumab
24 Phase II Study Assessing the Effect of BK Specific CTL Lines Generated by Ex Vivo Expansion in Patients With BK Virus Infection and JC Virus Infection Recruiting NCT02479698 Phase 2
25 Endoscopic Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Randomized Clinical Phase II Trial Recruiting NCT03040180 Phase 2 Electrochemotherapy with bleomycin
26 A Phase 2 Study to Evaluate the Efficacy and Safety of Adoptive Transfer of Autologous Tumor Infiltrating Lymphocytes in Patients With Advanced Solid Cancers Recruiting NCT03935893 Phase 2 Fludarabine + Cyclophosphamide combination
27 Non-Comparative, Open-Label, Multiple Cohort, Phase 1/2 Study of Nivolumab Monotherapy and Nivolumab Combination Therapy in Subjects With Virus-Positive and Virus-Negative Solid Tumors Recruiting NCT02488759 Phase 1, Phase 2 Nivolumab;Ipilimumab;Relatlimab;Daratumumab
28 A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies Recruiting NCT03126110 Phase 1, Phase 2 INCAGN01876;Nivolumab;Ipilimumab
29 UCDCC#271: A Phase I/II Trial of Epacadostat (Indolamine 2,3 Dioxygenase Inhibitor), Intralesional SD101 (Toll-receptor 9 Agonist), and Radiotherapy in Patients With Advanced Solid Tumors and Lymphoma Recruiting NCT03322384 Phase 1, Phase 2 epacadostat;SD-101
30 A Phase II Efficacy Study of Chemo-Radiotherapy in PET Stage II and III Merkel Cell Carcinoma of the Skin Active, not recruiting NCT01013779 Phase 2 Carboplatin;Etoposide
31 A Phase II, Open-Label, Multicenter Trial to Investigate the Clinical Activity and Safety of Avelumab (MSB0010718C) in Subjects With Merkel Cell Carcinoma Active, not recruiting NCT02155647 Phase 2 Avelumab
32 A Phase II Study of MK-3475 in Patients With Advanced Merkel Cell Carcinoma (MCC) Active, not recruiting NCT02267603 Phase 2
33 MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma Active, not recruiting NCT02514824 Phase 1, Phase 2 MLN0128
34 Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma Active, not recruiting NCT02036476 Phase 2 Cabozantinib
35 QUILT-3.063: A Phase 2 Study of Combination Therapy With an IL-15 Superagonist (N-803), Off-the-shelf CD16-targeted Natural Killer Cells (haNK), and Avelumab Without Cytotoxic Chemotherapy in Subjects With Merkel Cell Carcinoma (MCC) That Has Progressed on or After Treatment With a Checkpoint Inhibitor. Active, not recruiting NCT03853317 Phase 2
36 Phase 2 Study of aNK (Activated NK-92 Natural Killer Cells) Infusions in Combination With ALT-803 (IL-15) in Patients With Stage III (IIIB) or Stage IV Merkel Cell Carcinoma (MCC) Active, not recruiting NCT02465957 Phase 2
37 Study to Evaluate Cellular Adoptive Immunotherapy Using Polyclonal Autologous CD8+ Antigen-Specific T Cells for Metastatic Merkel Cell Carcinoma in Combination With MHC Class I Up-Regulation and the Anti-PD-L1 Antibody Avelumab Active, not recruiting NCT02584829 Phase 1, Phase 2 Avelumab
38 A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01949 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies Active, not recruiting NCT03241173 Phase 1, Phase 2 INCAGN01949;Nivolumab;Ipilimumab;INCAGN01949
39 A Phase 1/2 Safety and Efficacy Study of INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies Active, not recruiting NCT03277352 Phase 1, Phase 2 INCAGN01876;Epacadostat;Pembrolizumab
40 Phase 1/2 Study of Intratumoral G100 With Or Without Pembrolizumab In Patients With Follicular Non-Hodgkin's Lymphoma Active, not recruiting NCT02501473 Phase 1, Phase 2 G100;Pembrolizumab
41 A Phase 1b/2a, Open Label Study to Evaluate Anti-tumor Efficacy and Safety of rhIL-7-hyFc (NT-I7) in Combination With Anti-PD-L1 (Atezolizumab) in Patients With Anti-PD-1/PD-L1 naïve or Relapsed/Refractory High-risk Skin Cancers Not yet recruiting NCT03901573 Phase 1, Phase 2 NT-I7;atezolizumab
42 Phase II Multicenter Study of Talimogene Laherparepvec in Classic or Endemic Kaposi Sarcoma - KAPVEC Not yet recruiting NCT04065152 Phase 2 Talimogene laherparepvec
43 Avelumab (Bavencio) With IL-15 in Subjects With Clear-cell Renal Carcinoma Not yet recruiting NCT04150562 Phase 2 rhIL-15
44 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Suspended NCT02978625 Phase 2
45 Viral Oncoprotein Targeted Autologous T Cell Therapy for Merkel Cell Carcinoma Terminated NCT01758458 Phase 1, Phase 2
46 Phase II Study of the Tumor-targeting Human F16IL2 Monoclonal Antibody-cytokine Fusion Protein in Combination With Paclitaxel in Patients With Metastatic Merkel Cell Carcinoma Terminated NCT02054884 Phase 2 Arm A: F16IL2 in combination with paclitaxel;Arm B: Paclitaxel
47 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
48 NANT Merkel Cell Carcinoma (MCC) Vaccine: Combination Immunotherapy in Subjects With MCC Who Have Progressed on or After Anti-programmed Death-ligand 1 (PD-L1) Therapy Withdrawn NCT03167164 Phase 1, Phase 2 Capecitabine;Cisplatin;Cyclophosphamide;5-fluorouracil;Leucovorin;nab-Paclitaxel;omega-3-acid ethyl esters
49 Phase II Open-Label Trial of Ipilimumab for Metastatic Merkel Cell Carcinoma Withdrawn NCT01913691 Phase 2 Ipilimumab
50 A Proof-of-Concept Clinical Trial of Intratumoral Injection of GLA-SE, a Toll-like Receptor-4 Agonist, in Patients With Merkel Cell Carcinoma Completed NCT02035657 Phase 1

Search NIH Clinical Center for Merkel Cell Carcinoma

Genetic Tests for Merkel Cell Carcinoma

Anatomical Context for Merkel Cell Carcinoma

MalaCards organs/tissues related to Merkel Cell Carcinoma:

40
Skin, Lymph Node, T Cells, Lung, Breast, Thyroid, Kidney

Publications for Merkel Cell Carcinoma

Articles related to Merkel Cell Carcinoma:

(show top 50) (show all 2798)
# Title Authors PMID Year
1
Merkel cell carcinoma: lack of KIT positivity and implications for the use of imatinib mesylate. 54 61
19276970 2009
2
Metastatic Merkel cell carcinoma with positive expression of thyroid transcription factor-1--a case report. 54 61
19461245 2009
3
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. 54 61
19318809 2009
4
Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases. 54 61
18813128 2009
5
Merkel cell carcinoma within follicular cysts: report of two cases. 54 61
18988316 2008
6
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma. 54 61
18587322 2008
7
Expression of VEGF-A/C, VEGF-R2, PDGF-alpha/beta, c-kit, EGFR, Her-2/Neu, Mcl-1 and Bmi-1 in Merkel cell carcinoma. 54 61
18408656 2008
8
Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based tumorigenesis. 54 61
18084259 2008
9
TdT expression in Merkel cell carcinoma: potential diagnostic pitfall with blastic hematological malignancies and expanded immunohistochemical analysis. 54 61
17885674 2007
10
RKIP does not contribute to MAP kinase pathway silencing in the Merkel Cell Carcinoma cell line UISO. 54 61
17958888 2007
11
Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO. 54 61
17476292 2007
12
Expression of vascular endothelial growth factor receptor-2 in Merkel cell carcinoma. 54 61
17695419 2007
13
Merkel cell carcinoma metastasizing to the kidney mimicking primary neuroendocrine renal cancer. 54 61
17550389 2007
14
Merkel cell carcinoma: evaluation of KIT (CD117) expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib mesylate. 54 61
17381803 2007
15
Merkel cell tumor in a trichilemmal cyst: collision or association? 54 61
17414443 2007
16
Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma. 54 61
16498399 2006
17
Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung. 54 61
16625069 2006
18
Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype. 54 61
16538063 2006
19
Tenascin-C expression in Merkel cell carcinoma lymph node metastasis. 54 61
16499659 2006
20
CD56 staining in Merkel cell carcinoma and natural killer-cell lymphoma: magic bullet, diagnostic pitfall, or both? 54 61
16115052 2005
21
Reliability of sentinel lymph node biopsy for regional staging of head and neck Merkel cell carcinoma. 54 61
16027284 2005
22
B-cell specific activation protein encoded by the PAX-5 gene is commonly expressed in merkel cell carcinoma and small cell carcinomas. 54 61
15832095 2005
23
Tenascin-C in primary Merkel cell carcinoma. 54 61
15735164 2005
24
KIT receptor (CD117) expression in Merkel cell carcinoma. 54 61
14996126 2004
25
Expression of adhesion molecules and cytokeratin 20 in merkel cell carcinomas. 54 61
15299198 2004
26
[Merkel cell carcinoma. Clinical and histological differential diagnosis, diagnostic approach and therapy]. 54 61
14634746 2003
27
Expression of MUC 1 and Ep-CAM in Merkel cell carcinomas: implications for immunotherapy. 54 61
12844224 2003
28
Somatostatin analogue scintigraphy in Merkel cell tumours. 54 61
12828740 2003
29
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. 54 61
12605092 2003
30
Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers. 54 61
14586067 2003
31
Merkel cell carcinoma composed of small, intermediate and squamous cell foci showing mutually exclusive expression of neuroendocrine markers and cytokeratin 20. 54 61
12534628 2003
32
CD117 (KIT receptor) expression in Merkel cell carcinoma. 54 61
12142606 2002
33
Immunostaining for cytokeratin 20 improves detection of micrometastatic Merkel cell carcinoma in sentinel lymph nodes. 54 61
12004304 2002
34
Primary undifferentiated small cell carcinoma (Merkel cell carcinoma) in a patient after heart transplantation--case report. 54 61
12476622 2002
35
Merkel cell carcinoma of the parotid gland associated with Warthin tumour: report of two cases. 54 61
11683932 2001
36
Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. 54 61
11533085 2001
37
[Merkel cell carcinoma: a diagnostic and therapeutic challenge]. 54 61
11357530 2001
38
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. 54 61
11175640 2001
39
Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas from other small cell carcinomas. 54 61
10976695 2000
40
Analysis of thyroid transcription factor-1 and cytokeratin 20 separates merkel cell carcinoma from small cell carcinoma of lung. 54 61
10728812 2000
41
Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. 54 61
10757334 2000
42
Cytokeratin 20: a marker for diagnosing Merkel cell carcinoma. 54 61
10027519 1999
43
Pagetoid Merkel cell carcinoma: epidermal origin of the tumor. 54 61
9870679 1998
44
Mixed Merkel cell carcinoma and squamous cell carcinoma of the skin. 54 61
9810922 1998
45
Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. 54 61
9042291 1997
46
Aberrant FHIT transcripts in Merkel cell carcinoma. 54 61
8653678 1996
47
Cutaneous lymphoma-simulating Merkel cell carcinoma-molecular genetic demonstration of a clonal disease with divergent immunophenotypes. 54 61
8539236 1995
48
[Detection of somatostatin receptors in tumors in the area of the head and neck and their clinical importance]. 54 61
7908199 1994
49
Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma. 54 61
8432919 1993
50
Immunobiology of Merkel cell carcinoma. 61
31972727 2020

Variations for Merkel Cell Carcinoma

ClinVar genetic disease variations for Merkel Cell Carcinoma:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PIK3CA NM_006218.4(PIK3CA):c.1412C>T (p.Pro471Leu)SNV not provided 376359 rs1057519872 3:178928226-178928226 3:179210438-179210438

Cosmic variations for Merkel Cell Carcinoma:

9 (show top 50) (show all 2679)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM89651592 SMARCA4 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
2 COSM87174055 PIK3CA skin,head neck,carcinoma,Merkel cell carcinoma c.56G>A p.R19K 3:179198881-179198881 12
3 COSM122271260 skin,upper extremity,carcinoma,Merkel cell carcinoma c.422G>A p.R141H 17:7673802-7673802 12
4 COSM148659109 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
5 COSM151419212 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
6 COSM121875541 skin,upper extremity,carcinoma,Merkel cell carcinoma c.422G>A p.R141H 17:7673802-7673802 12
7 COSM142837551 skin,head neck,carcinoma,Merkel cell carcinoma c.742C>T p.R248W 17:7674221-7674221 12
8 COSM106808052 skin,head neck,carcinoma,Merkel cell carcinoma c.3757C>G p.R1253G 19:11033308-11033308 12
9 COSM112253106 skin,upper extremity,carcinoma,Merkel cell carcinoma c.818G>A p.R273H 17:7673802-7673802 12
10 COSM112774039 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
11 COSM142560553 skin,head neck,carcinoma,Merkel cell carcinoma c.625C>T p.R209W 17:7674221-7674221 12
12 COSM140833474 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
13 COSM105619828 skin,upper extremity,carcinoma,Merkel cell carcinoma c.782+379G>A p.? 17:7673802-7673802 12
14 COSM148971186 skin,head neck,carcinoma,Merkel cell carcinoma c.56G>A p.R19K 3:179198881-179198881 12
15 COSM106053434 skin,head neck,carcinoma,Merkel cell carcinoma c.742C>T p.R248W 17:7674221-7674221 12
16 COSM138930386 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
17 COSM142559879 skin,upper extremity,carcinoma,Merkel cell carcinoma c.701G>A p.R234H 17:7673802-7673802 12
18 COSM148047428 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
19 COSM151244957 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
20 COSM112253879 skin,head neck,carcinoma,Merkel cell carcinoma c.742C>T p.R248W 17:7674221-7674221 12
21 COSM143156594 skin,upper extremity,carcinoma,Merkel cell carcinoma c.341G>A p.R114H 17:7673802-7673802 12
22 COSM142837073 skin,upper extremity,carcinoma,Merkel cell carcinoma c.818G>A p.R273H 17:7673802-7673802 12
23 COSM122734399 skin,head neck,carcinoma,Merkel cell carcinoma c.346C>T p.R116W 17:7674221-7674221 12
24 COSM151942079 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
25 COSM93183975 skin,head neck,carcinoma,Merkel cell carcinoma c.742C>T p.R248W 17:7674221-7674221 12
26 COSM131010966 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
27 COSM109727685 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
28 COSM144650760 skin,upper extremity,carcinoma,Merkel cell carcinoma c.701G>A p.R234H 17:7673802-7673802 12
29 COSM106052890 skin,upper extremity,carcinoma,Merkel cell carcinoma c.818G>A p.R273H 17:7673802-7673802 12
30 COSM111758868 skin,head neck,carcinoma,Merkel cell carcinoma c.742C>T p.R248W 17:7674221-7674221 12
31 COSM111385260 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
32 COSM143371145 skin,head neck,carcinoma,Merkel cell carcinoma c.625C>T p.R209W 17:7674221-7674221 12
33 COSM151620874 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
34 COSM151519071 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
35 COSM149458253 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
36 COSM151566865 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
37 COSM150568050 skin,head neck,carcinoma,Merkel cell carcinoma c.3565C>G p.R1189G 19:11033308-11033308 12
38 COSM149315904 ZFHX3 skin,NS,carcinoma,Merkel cell carcinoma c.6661G>A p.E2221K 16:72796021-72796021 9
39 COSM149319963 ZFHX3 skin,NS,carcinoma,Merkel cell carcinoma c.6172C>T p.P2058S 16:72796510-72796510 9
40 COSM149314744 ZFHX3 skin,NS,carcinoma,Merkel cell carcinoma c.10363C>T p.P3455S 16:72787913-72787913 9
41 COSM143036760 YAP1 skin,NS,carcinoma,Merkel cell carcinoma c.371G>C p.R124P 11:102114193-102114193 9
42 COSM143037693 YAP1 skin,NS,carcinoma,Merkel cell carcinoma c.630G>C p.M210I 11:102162513-102162513 9
43 COSM143037764 YAP1 skin,NS,carcinoma,Merkel cell carcinoma c.380C>T p.S127F 11:102114202-102114202 9
44 COSM88291561 VHL skin,head neck,carcinoma,NS c.337C>T p.R113* 3:10142184-10142184 9
45 COSM88294994 VHL skin,head neck,carcinoma,NS c.394C>T p.Q132* 3:10146567-10146567 9
46 COSM97137781 VEGFA skin,NS,carcinoma,Merkel cell carcinoma c.983G>A p.G328E 6:43780752-43780752 9
47 COSM97138433 VEGFA skin,NS,carcinoma,Merkel cell carcinoma c.855+1G>T p.? 6:43777666-43777666 9
48 COSM131093526 TSHR skin,NS,carcinoma,Merkel cell carcinoma c.1105G>A p.E369K 14:81143163-81143163 9
49 COSM87035818 TSC2 skin,NS,carcinoma,Merkel cell carcinoma c.5213C>T p.S1738F 16:2088279-2088279 9
50 COSM87042542 TSC2 skin,NS,carcinoma,Merkel cell carcinoma c.2519C>T p.A840V 16:2074363-2074363 9

Copy number variations for Merkel Cell Carcinoma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 32219 1 34600000 44100000 Amplification MYCL1 Merkel cell carcinoma
2 77110 13 40100000 73300000 Deletion Merkel cell carcinoma
3 200959 5 63200000 102800000 Deletion Merkel cell carcinoma

Expression for Merkel Cell Carcinoma

Search GEO for disease gene expression data for Merkel Cell Carcinoma.

Pathways for Merkel Cell Carcinoma

GO Terms for Merkel Cell Carcinoma

Cellular components related to Merkel Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 PTPRC PDCD1 NCAM1 KIT CD274

Biological processes related to Merkel Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hematopoietic progenitor cell differentiation GO:0002244 9.5 TP53 PTPRC KIT
2 viral process GO:0016032 9.43 TP53 RB1 NCAM1 KRT8 KRT7 KDR
3 hepatocyte apoptotic process GO:0097284 9.4 RB1 KRT8
4 bone marrow development GO:0048539 9.37 TP53 PTPRC
5 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.26 TP53 MUC1
6 mast cell chemotaxis GO:0002551 9.16 KIT CHGA
7 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Molecular functions related to Merkel Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 TP53 PAX5 NKX2-1 MUC1 ATOH1
2 RNA polymerase II regulatory region DNA binding GO:0001012 8.62 RB1 NKX2-1

Sources for Merkel Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....