MCID: MSN001
MIFTS: 48

Mesangial Proliferative Glomerulonephritis

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

MalaCards integrated aliases for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 12 53 15 73
Glomerulonephritis - Mesangial Proliferative 53
Glomerulonephritis Mesangial Proliferative 55
Mesangioproliferative Glomerulonephritis 53
Mesangial Proliferative Gn 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4783
NCIt 50 C35445
SNOMED-CT 68 35546006
UMLS 73 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

NIH Rare Diseases : 53 Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. Many experts consider it a variant of minimal change disease, but some experts believe it is a separate condition. It may present with nephrotic syndrome, which is a group of symptoms that include protein in the urine (proteinuria), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. It can also present with blood in the urine (hematuria). MPGN is characterized by an increased number of mesangial cells in the glomeruli in the kidneys and damage to the glomeruli. Glomeruli are the structures that help filter wastes and fluids. MPGN may occur in several renal diseases such as IgA nephropathy (commonly), IgM nephropathy, lupus nephritis, and C1q nephropathy. However, in some cases, the underlying cause of MPGN remains unclear. Treatment may depend on the cause (if known) and may include steroids, mycophenolate mofetil, and/or cyclophosphamide, and other therapies to treat specific symptoms. Most people with MPGN have a good prognosis, but some may develop chronic kidney disease, which can progress to end stage renal failure.

MalaCards based summary : Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to proliferative glomerulonephritis and iga glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Losartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and brain, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

Related Diseases for Mesangial Proliferative Glomerulonephritis

Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 proliferative glomerulonephritis 31.6 CCL2 CD79A IL6
2 iga glomerulonephritis 30.2 CCL2 CD79A IL6
3 lipoid nephrosis 30.2 CCL2 CD79A
4 acute poststreptococcal glomerulonephritis 30.1 CD79A EDN1
5 c1q deficiency 11.4
6 glomerulonephritis 11.1
7 focal segmental glomerulosclerosis 4 10.5
8 nephrotic syndrome, type 6 10.5
9 focal segmental glomerulosclerosis 10.5
10 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.5
11 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 10.5
12 nephrotic syndrome 10.5
13 immunoglobulin alpha deficiency 10.3
14 laryngitis 10.2 FGF2 IL6
15 diabetic foot ulcers 10.2 CCL2 IL6
16 denture stomatitis 10.2 CCL2 IL6
17 familial mediterranean fever 10.2
18 hepatitis 10.2
19 interstitial nephritis 10.2
20 viral infectious disease 10.2
21 polymyositis 10.2
22 stachybotrys chartarum 10.2 CCL2 IL6
23 macular retinal edema 10.2 CCL2 IL6
24 ischemic heart disease 10.2 CCL2 IL6
25 post-thrombotic syndrome 10.2 CCL2 IL6
26 meconium aspiration syndrome 10.2 EDN1 IL6
27 vitreous disease 10.2 CCL2 FGF2
28 viral meningitis 10.2 CCL2 IL6
29 radiculopathy 10.2 CCL2 IL6
30 bacteriuria 10.2 CCL2 IL6
31 nonspecific interstitial pneumonia 10.2 CCL2 FGF2
32 exanthema subitum 10.2 FGF2 IL6
33 stromal keratitis 10.2 CCL2 IL6
34 focal segmental glomerulosclerosis 1 10.2
35 systolic heart failure 10.1 EDN1 IL6
36 acute cystitis 10.1 CCL2 IL6
37 apnea, obstructive sleep 10.1 EDN1 IL6
38 immune-complex glomerulonephritis 10.1 CCR1 CCR5
39 diabetic macular edema 10.1 CCL2 FGF2 IL6
40 angina pectoris 10.1 EDN1 IL6
41 diabetic angiopathy 10.1 CCL2 EDN1
42 limb ischemia 10.1 EDN1 FGF2 IL6
43 dengue shock syndrome 10.1 CCL2 IL6
44 idiopathic hypercalciuria 10.1 EDN1 FGF2
45 complex regional pain syndrome 10.1 CCL2 EDN1 IL6
46 arteries, anomalies of 10.1 CCL2 EDN1 IL6
47 urinary system disease 10.1 CCL2 EDN1 IL6
48 interstitial lung disease 10.1 CCL2 EDN1 IL6
49 lung disease 10.1 CCL2 EDN1 IL6
50 nervous system disease 10.1 CCL2 CCR1 IL6

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to Mesangial Proliferative Glomerulonephritis

Symptoms & Phenotypes for Mesangial Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 AXL CCR1 CCR5 EDN1 FGF2 GAS6
2 hematopoietic system MP:0005397 9.8 AXL CCR1 CCR5 CD79A FGF2 GAS6
3 homeostasis/metabolism MP:0005376 9.76 AXL CCR1 CCR5 CD79A EDN1 FGF2
4 liver/biliary system MP:0005370 9.35 AXL CCR1 CCR5 CD79A IL6
5 renal/urinary system MP:0005367 9.02 CCR1 CD79A EDN1 GAS6 IL6

Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
3
Ramipril Approved Phase 4 87333-19-5 5362129
4
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
5 Serine Proteinase Inhibitors Phase 4
6 Vasoconstrictor Agents Phase 4
7 Anti-Arrhythmia Agents Phase 4
8
protease inhibitors Phase 4
9 Angiotensin II Type 1 Receptor Blockers Phase 4
10 Immunoglobulin A Phase 4
11 HIV Protease Inhibitors Phase 4
12 Angiotensinogen Phase 4
13 Angiotensin Receptor Antagonists Phase 4
14 Angiotensin-Converting Enzyme Inhibitors Phase 4
15 Antihypertensive Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis Completed NCT01115426 Phase 4 Ramipril or losartan
2 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
3 The Canadian Glomerulonephritis Registry and Translational Research Initiative Recruiting NCT03460054

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

Anatomical Context for Mesangial Proliferative Glomerulonephritis

MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

41
Kidney, Lung, Brain, T Cells, Monocytes, Heart, B Cells

Publications for Mesangial Proliferative Glomerulonephritis

Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50) (show all 148)
# Title Authors Year
1
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )
2018
2
Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress. ( 29607219 )
2018
3
Suppressor of Cytokine Signaling-1/STAT1 Regulates Renal Inflammation in Mesangial Proliferative Glomerulonephritis Models. ( 30214448 )
2018
4
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
5
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
6
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
7
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
8
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
9
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
10
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. ( 24701045 )
2014
11
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. ( 24858931 )
2014
12
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. ( 24649023 )
2013
13
Efficacy of antisense monocyte chemoattractant protein-1 (MCP-1) in a rat model of mesangial proliferative glomerulonephritis. ( 23991758 )
2013
14
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. ( 22641568 )
2013
15
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. ( 22641580 )
2013
16
Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report. ( 22261745 )
2013
17
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. ( 22607047 )
2012
18
Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis. ( 22286178 )
2012
19
Successful treatment of a mesangial proliferative glomerulonephritis with interstitial nephritis associated with Castleman's disease by an anti-interleukin-6 receptor antibody (tocilizumab). ( 22687845 )
2012
20
Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. ( 22576627 )
2012
21
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. ( 21349934 )
2011
22
Protein kinase C I^ inhibition ameliorates experimental mesangial proliferative glomerulonephritis. ( 21575103 )
2011
23
Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. ( 20110667 )
2010
24
Primary SjAPgren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child. ( 19902265 )
2010
25
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. ( 19617668 )
2009
26
Effect of the absence of interleukin-12 on mesangial proliferative glomerulonephritis induced by habu snake venom. ( 20030533 )
2009
27
Pathological regression by angiotensin II type 1 receptor blockade in patients with mesangial proliferative glomerulonephritis. ( 18497456 )
2008
28
The relation of IgM deposition to clinical parameters and histomorphometry in childhood mesangial proliferative glomerulonephritis. ( 18093746 )
2008
29
Tranilast ameliorates experimental mesangial proliferative glomerulonephritis. ( 18480612 )
2008
30
Mesangial proliferative glomerulonephritis with or without IgA deposits: the morphological characters in psoriasis vulgaris. ( 18332636 )
2008
31
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. ( 17717029 )
2007
32
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. ( 16541204 )
2007
33
Mesangial proliferative glomerulonephritis with aldosterone-producing adenoma. ( 17593517 )
2007
34
Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. ( 16807544 )
2006
35
The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis. ( 16179805 )
2006
36
Acute renal failure due to mesangial proliferative glomerulonephritis in a pregnant woman with primary SjAPgren's syndrome. ( 15917985 )
2006
37
Mesangial proliferative glomerulonephritis after autologous stem cell transplantation. ( 16860199 )
2006
38
Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. ( 16247710 )
2005
39
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. ( 15947989 )
2005
40
Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature. ( 15971069 )
2005
41
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. ( 16092667 )
2005
42
All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. ( 15795517 )
2005
43
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. ( 16334979 )
2005
44
Effect of lipo-prostaglandin E1 on mesangial proliferative glomerulonephritis in rats. ( 16463661 )
2005
45
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. ( 17642763 )
2004
46
Gene expression profile in experimental mesangial proliferative glomerulonephritis. ( 15351794 )
2004
47
[Mesangial proliferative glomerulonephritis]. ( 15500128 )
2004
48
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. ( 14600028 )
2003
49
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. ( 12375274 )
2002
50
Mesangial proliferative glomerulonephritis triggered by spleno-renal shunt in a cirrhotic patient. ( 12038661 )
2002

Variations for Mesangial Proliferative Glomerulonephritis

Expression for Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for Mesangial Proliferative Glomerulonephritis

Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 AXL CCL2 CCR1 CCR5 FGF2 GAS6
2
Show member pathways
13.46 AXL CCL2 CCR1 CCR5 EDN1 IL6
3
Show member pathways
13.33 AXL CCL2 FGF2 GAS6 IL6 PDGFD
4
Show member pathways
13.14 CCL2 CCR1 CCR5 FGF2 IL6
5
Show member pathways
13.07 AXL FGF2 GAS6 IL6 PDGFD
6
Show member pathways
13.06 AXL CD79A FGF2 GAS6 IL6 PDGFD
7
Show member pathways
12.93 CCL2 CCR1 CCR5 FGF2 GAS6 IL6
8
Show member pathways
12.85 CD79A FGF2 GAS6 IL6 PDGFD
9
Show member pathways
12.82 CCL2 CCR1 CCR5 FGF2 IL6
10
Show member pathways
12.76 AXL CCL2 FGF2 GAS6 IL6 PDGFD
11
Show member pathways
12.7 AXL CCL2 CCR1 CCR5 FGF2 GAS6
12
Show member pathways
12.53 FGF2 GAS6 IL6 PDGFD
13
Show member pathways
12.5 AXL FGF2 GAS6 IL6 PDGFD
14
Show member pathways
12.15 AXL FGF2 GAS6 IL6 PDGFD
15
Show member pathways
12.06 FGF2 GAS6 IL6 PDGFD
16 11.96 AXL FGF2 GAS6
17
Show member pathways
11.83 CCL2 CCR1 CCR5
18 11.82 CCR1 CD79A IL6
19 11.81 CCL2 FGF2 IL6
20 11.78 CCL2 EDN1 IL6
21
Show member pathways
11.78 CCL2 FGF2 GAS6 IL6 PDGFD
22 11.72 CCR1 CCR5 IL6
23 11.7 CCL2 EDN1 IL6
24 11.5 FGF2 GAS6 IL6 PDGFD
25 11.26 CCL2 EDN1 FGF2 IL6
26 11.16 CCL2 IL6
27 10.64 AXL CCL2 FGF2 GAS6 IL6 PDGFD
28 10.61 CCL2 CCR1 CCR5 IL6

GO Terms for Mesangial Proliferative Glomerulonephritis

Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 AXL CCL2 EDN1 FGF2 GAS6 IL6

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 EDN1 FGF2 IL6 PDGFD
2 immune response GO:0006955 9.94 CCL2 CCR1 CCR5 IL6
3 positive regulation of cell migration GO:0030335 9.84 CCR1 EDN1 PDGFD
4 cell-cell signaling GO:0007267 9.84 CCR1 CCR5 EDN1
5 MAPK cascade GO:0000165 9.83 CCL2 CCR5 FGF2
6 positive regulation of protein kinase B signaling GO:0051897 9.81 AXL FGF2 GAS6
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 CCR1 CCR5 EDN1
8 platelet activation GO:0030168 9.78 AXL GAS6 IL6
9 calcium-mediated signaling GO:0019722 9.75 CCR1 CCR5 EDN1
10 cell chemotaxis GO:0060326 9.74 CCL2 CCR1 CCR5
11 cellular response to lipopolysaccharide GO:0071222 9.73 AXL CCL2 CCR5 IL6
12 inflammatory response GO:0006954 9.72 AXL CCL2 CCR1 CCR5 IL6
13 chemokine-mediated signaling pathway GO:0070098 9.69 CCL2 CCR1 CCR5
14 positive regulation of MAP kinase activity GO:0043406 9.67 EDN1 FGF2 PDGFD
15 chemotaxis GO:0006935 9.67 CCL2 CCR1 CCR5 FGF2
16 regulation of angiogenesis GO:0045765 9.66 FGF2 IL6
17 negative regulation of interferon-gamma production GO:0032689 9.65 AXL GAS6
18 cellular response to hydrogen peroxide GO:0070301 9.65 AXL IL6 PDGFD
19 cytokine-mediated signaling pathway GO:0019221 9.65 CCL2 CCR1 CCR5 FGF2 IL6
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.63 EDN1 IL6 PDGFD
21 apoptotic cell clearance GO:0043277 9.62 AXL GAS6
22 dendritic cell chemotaxis GO:0002407 9.62 CCR1 CCR5
23 viral genome replication GO:0019079 9.61 CCL2 GAS6
24 dendritic cell differentiation GO:0097028 9.6 AXL GAS6
25 cellular response to interferon-alpha GO:0035457 9.59 AXL GAS6
26 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.58 AXL GAS6
27 protein kinase B signaling GO:0043491 9.58 AXL CCL2 GAS6
28 enzyme linked receptor protein signaling pathway GO:0007167 9.56 AXL GAS6
29 positive regulation of natural killer cell differentiation GO:0032825 9.55 AXL GAS6
30 cell surface receptor signaling pathway GO:0007166 9.55 CCL2 CCR1 CCR5 CD79A EDN1
31 fusion of virus membrane with host plasma membrane GO:0019064 9.54 CCR5 GAS6
32 negative regulation of dendritic cell apoptotic process GO:2000669 9.52 AXL GAS6
33 regulation of signaling receptor activity GO:0010469 9.43 CCL2 EDN1 FGF2 GAS6 IL6 PDGFD
34 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.1 AXL CCL2 CCR1 FGF2 GAS6 PDGFD
35 signal transduction GO:0007165 10.12 AXL CCL2 CCR1 CCR5 FGF2 GAS6

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.5 FGF2 IL6 PDGFD
2 phosphatidylinositol phospholipase C activity GO:0004435 9.43 CCR1 CCR5
3 chemokine binding GO:0019956 9.4 CCR1 CCR5
4 C-C chemokine binding GO:0019957 9.37 CCR1 CCR5
5 C-C chemokine receptor activity GO:0016493 9.26 CCR1 CCR5
6 cytokine activity GO:0005125 9.26 CCL2 EDN1 FGF2 IL6
7 chemokine receptor activity GO:0004950 9.16 CCR1 CCR5
8 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR1 CCR5

Sources for Mesangial Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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