MCID: MSN001
MIFTS: 44

Mesangial Proliferative Glomerulonephritis

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

MalaCards integrated aliases for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 12 53 15 73
Glomerulonephritis - Mesangial Proliferative 53
Glomerulonephritis Mesangial Proliferative 55
Mesangioproliferative Glomerulonephritis 53
Mesangial Proliferative Gn 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4783
NCIt 50 C35445
SNOMED-CT 68 35546006
UMLS 73 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

NIH Rare Diseases : 53 Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. Many experts consider it a variant of minimal change disease, but some experts believe it is a separate condition. It may present with nephrotic syndrome, which is a group of symptoms that include protein in the urine (proteinuria), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. It can also present with blood in the urine (hematuria). MPGN is characterized by an increased number of mesangial cells in the glomeruli in the kidneys and damage to the glomeruli. Glomeruli are the structures that help filter wastes and fluids. MPGN may occur in several renal diseases such as IgA nephropathy (commonly), IgM nephropathy, lupus nephritis, and C1q nephropathy. However, in some cases, the underlying cause of MPGN remains unclear. Treatment may depend on the cause (if known) and may include steroids, mycophenolate mofetil, and/or cyclophosphamide, and other therapies to treat specific symptoms. Most people with MPGN have a good prognosis, but some may develop chronic kidney disease, which can progress to end stage renal failure.

MalaCards based summary : Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to proliferative glomerulonephritis and acute poststreptococcal glomerulonephritis. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Losartan and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related phenotype is nervous system.

Wikipedia : 76 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

Related Diseases for Mesangial Proliferative Glomerulonephritis

Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 proliferative glomerulonephritis 31.6 CCL2 CD79A IL6
2 acute poststreptococcal glomerulonephritis 30.4 CD79A EDN1
3 iga glomerulonephritis 30.2 CCL2 CD79A IL6
4 c1q deficiency 11.3
5 glomerulonephritis 11.0
6 laryngitis 10.7 FGF2 IL6
7 denture stomatitis 10.7 CCL2 IL6
8 anterior uveitis 10.7 CCL2 IL6
9 stachybotrys chartarum 10.6 CCL2 IL6
10 post-thrombotic syndrome 10.6 CCL2 IL6
11 angina pectoris 10.6 EDN1 IL6
12 meconium aspiration syndrome 10.6 EDN1 IL6
13 stromal keratitis 10.6 CCL2 IL6
14 acute cystitis 10.6 CCL2 IL6
15 nonspecific interstitial pneumonia 10.6 CCL2 FGF2
16 viral meningitis 10.5 CCL2 IL6
17 dengue shock syndrome 10.5 CCL2 IL6
18 apnea, obstructive sleep 10.5 EDN1 IL6
19 polyclonal hypergammaglobulinemia 10.5 CD79A IL6
20 extrinsic cardiomyopathy 10.5 CCL2 IL6
21 microscopic colitis 10.5 CD79A IL6
22 osteosclerotic myeloma 10.5 CD79A IL6
23 viral encephalitis 10.4 CCL2 IL6
24 diffuse glomerulonephritis 10.4 CD79A FGF2
25 intussusception 10.4 CD79A IL6
26 hypersensitivity reaction type iii disease 10.4 CD79A IL6
27 idiopathic hypercalciuria 10.4 EDN1 FGF2
28 primary amebic meningoencephalitis 10.4 CD79A IL6
29 monoclonal gammopathy of uncertain significance 10.4 CD79A IL6
30 diabetic angiopathy 10.4 CCL2 EDN1
31 bacteriuria 10.4 CD79A IL6
32 acute proliferative glomerulonephritis 10.4 CCL2 CD79A
33 plasma cell neoplasm 10.4 CD79A IL6
34 focal segmental glomerulosclerosis 4 10.4
35 focal segmental glomerulosclerosis 10.4
36 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.4
37 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 10.4
38 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 10.4
39 chikungunya 10.4 CCL2 IL6
40 gingival disease 10.4 CD79A IL6
41 nephrotic syndrome 10.4
42 commensal bacterial infectious disease 10.4 CD79A IL6
43 retinal vein occlusion 10.3 CCL2 IL6
44 cow milk allergy 10.3 CCR5 CD79A
45 lipoid nephrosis 10.3 CCL2 CD79A
46 crescentic glomerulonephritis 10.3 CCL2 CCR5
47 protein-energy malnutrition 10.3 CD79A IL6
48 diabetic macular edema 10.3 CCL2 FGF2 IL6
49 lymph node disease 10.3 CD79A IL6
50 orofacial granulomatosis 10.3 CCR5 CD79A

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to Mesangial Proliferative Glomerulonephritis

Symptoms & Phenotypes for Mesangial Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 AXL CCR5 CD79A EDN1 FGF2 IL6

Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Ramipril Approved Phase 4 87333-19-5 5362129
3
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
4
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
5
protease inhibitors Phase 4
6 Serine Proteinase Inhibitors Phase 4
7 HIV Protease Inhibitors Phase 4
8 Angiotensin II Type 1 Receptor Blockers Phase 4
9 Angiotensin Receptor Antagonists Phase 4
10 Angiotensin-Converting Enzyme Inhibitors Phase 4
11 Angiotensinogen Phase 4
12 Vasoconstrictor Agents Phase 4
13 Anti-Arrhythmia Agents Phase 4
14 Immunoglobulin A Phase 4
15 Antihypertensive Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis Completed NCT01115426 Phase 4 Ramipril or losartan
2 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Recruiting NCT03201406
3 The Canadian Glomerulonephritis Registry and Translational Research Initiative Recruiting NCT03460054

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

Anatomical Context for Mesangial Proliferative Glomerulonephritis

MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

41
Kidney, Endothelial, T Cells, Lung, Brain, Monocytes

Publications for Mesangial Proliferative Glomerulonephritis

Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50) (show all 145)
# Title Authors Year
1
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )
2018
2
Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress. ( 29607219 )
2018
3
Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change? ( 28621006 )
2017
4
Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice. ( 27815652 )
2016
5
Pityriasis rubra pilaris and mesangial proliferative glomerulonephritis in a child: Association or coincidence? ( 26937085 )
2016
6
C3 mesangial proliferative glomerulonephritis initially presenting with atypical hemolytic uremic syndrome: a case report. ( 27460033 )
2016
7
Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls. ( 26443483 )
2015
8
Multicentric Castleman's disease with renal amyloidosis and mesangial proliferative glomerulonephritis: a case report. ( 25932265 )
2015
9
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection. ( 24701045 )
2014
10
Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis. ( 24858931 )
2014
11
Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study. ( 24649023 )
2013
12
Efficacy of antisense monocyte chemoattractant protein-1 (MCP-1) in a rat model of mesangial proliferative glomerulonephritis. ( 23991758 )
2013
13
Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis. ( 22641568 )
2013
14
Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology. ( 22641580 )
2013
15
Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report. ( 22261745 )
2013
16
Urinary protein markers predict the severity of renal histological lesions in children with mesangial proliferative glomerulonephritis. ( 22607047 )
2012
17
Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis. ( 22286178 )
2012
18
Successful treatment of a mesangial proliferative glomerulonephritis with interstitial nephritis associated with Castleman's disease by an anti-interleukin-6 receptor antibody (tocilizumab). ( 22687845 )
2012
19
Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. ( 22576627 )
2012
20
Single application of low-dose mycophenolate mofetil-OX7-immunoliposomes ameliorates experimental mesangial proliferative glomerulonephritis. ( 21349934 )
2011
21
Protein kinase C I^ inhibition ameliorates experimental mesangial proliferative glomerulonephritis. ( 21575103 )
2011
22
Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. ( 20110667 )
2010
23
Primary SjAPgren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child. ( 19902265 )
2010
24
Nephroquiz 2: differential diagnoses of mesangial proliferative glomerulonephritis. ( 19617668 )
2009
25
Effect of the absence of interleukin-12 on mesangial proliferative glomerulonephritis induced by habu snake venom. ( 20030533 )
2009
26
Pathological regression by angiotensin II type 1 receptor blockade in patients with mesangial proliferative glomerulonephritis. ( 18497456 )
2008
27
The relation of IgM deposition to clinical parameters and histomorphometry in childhood mesangial proliferative glomerulonephritis. ( 18093746 )
2008
28
Tranilast ameliorates experimental mesangial proliferative glomerulonephritis. ( 18480612 )
2008
29
Mesangial proliferative glomerulonephritis with or without IgA deposits: the morphological characters in psoriasis vulgaris. ( 18332636 )
2008
30
Chronic urticaria and mesangial proliferative glomerulonephritis: a case report. ( 17717029 )
2007
31
Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes. ( 16541204 )
2007
32
Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. ( 16807544 )
2006
33
The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis. ( 16179805 )
2006
34
Acute renal failure due to mesangial proliferative glomerulonephritis in a pregnant woman with primary SjAPgren's syndrome. ( 15917985 )
2006
35
Mesangial proliferative glomerulonephritis after autologous stem cell transplantation. ( 16860199 )
2006
36
Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. ( 16247710 )
2005
37
Clinicopathologic features, outcome, and therapeutic interventions in four children with isolated C3 mesangial proliferative glomerulonephritis. ( 15947989 )
2005
38
Familial Mediterranean fever and mesangial proliferative glomerulonephritis: report of a case and review of the literature. ( 15971069 )
2005
39
Immunohistochemical analysis of the interstitial mast cells in rebiopsied patients with idiopathic mesangial proliferative glomerulonephritis. ( 16092667 )
2005
40
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. ( 16334979 )
2005
41
Effect of lipo-prostaglandin E1 on mesangial proliferative glomerulonephritis in rats. ( 16463661 )
2005
42
All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. ( 15795517 )
2005
43
Pulse cyclophosphamide therapy in steroid resistant nephrotic syndrome associated with mesangial proliferative glomerulonephritis. ( 17642763 )
2004
44
Gene expression profile in experimental mesangial proliferative glomerulonephritis. ( 15351794 )
2004
45
[Mesangial proliferative glomerulonephritis]. ( 15500128 )
2004
46
Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. ( 14600028 )
2003
47
Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis. ( 12375274 )
2002
48
Mesangial proliferative glomerulonephritis triggered by spleno-renal shunt in a cirrhotic patient. ( 12038661 )
2002
49
Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. ( 11982588 )
2002
50
P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis. ( 12371966 )
2002

Variations for Mesangial Proliferative Glomerulonephritis

Expression for Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for Mesangial Proliferative Glomerulonephritis

Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 AXL CCL2 CCR5 FGF2 GAS6 IL6
2
Show member pathways
13.43 AXL CD79A FGF2 GAS6 IL6 PDGFD
3
Show member pathways
13.19 AXL CCL2 FGF2 GAS6 IL6 PDGFD
4
Show member pathways
13.01 AXL FGF2 GAS6 IL6 PDGFD
5
Show member pathways
12.99 AXL CD79A FGF2 GAS6 IL6 PDGFD
6
Show member pathways
12.95 CCL2 CCR5 FGF2 GAS6 IL6 PDGFD
7
Show member pathways
12.85 AXL CCL2 CCR5 FGF2 GAS6 IL6
8
Show member pathways
12.75 CD79A FGF2 GAS6 IL6 PDGFD
9
Show member pathways
12.46 FGF2 GAS6 IL6 PDGFD
10
Show member pathways
12.39 AXL FGF2 GAS6 IL6 PDGFD
11
Show member pathways
12.31 AXL CCL2 FGF2 GAS6 IL6 PDGFD
12 11.89 AXL FGF2 GAS6
13 11.76 CCL2 FGF2 IL6
14 11.72 CCL2 EDN1 IL6
15 11.67 CCL2 EDN1 IL6
16
Show member pathways
11.67 CCL2 FGF2 GAS6 IL6 PDGFD
17 11.23 CCL2 CCR5 IL6
18 11.21 FGF2 PDGFD
19 11.11 CCL2 IL6
20 10.72 CCL2 EDN1 FGF2 IL6

GO Terms for Mesangial Proliferative Glomerulonephritis

Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL2 EDN1 FGF2 GAS6 IL6 PDGFD
2 extracellular space GO:0005615 9.17 AXL CCL2 EDN1 FGF2 GAS6 IL6

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 EDN1 FGF2 IL6 PDGFD
2 inflammatory response GO:0006954 9.88 AXL CCL2 CCR5 IL6
3 cytokine-mediated signaling pathway GO:0019221 9.81 CCL2 CCR5 FGF2 IL6
4 chemotaxis GO:0006935 9.78 CCL2 CCR5 FGF2
5 positive regulation of protein kinase B signaling GO:0051897 9.77 AXL FGF2 GAS6
6 platelet activation GO:0030168 9.74 AXL GAS6 IL6
7 cell surface receptor signaling pathway GO:0007166 9.73 CCL2 CCR5 CD79A EDN1
8 monocyte chemotaxis GO:0002548 9.63 CCL2 IL6
9 negative regulation of tumor necrosis factor production GO:0032720 9.63 AXL GAS6
10 regulation of angiogenesis GO:0045765 9.62 FGF2 IL6
11 negative regulation of interferon-gamma production GO:0032689 9.62 AXL GAS6
12 apoptotic cell clearance GO:0043277 9.59 AXL GAS6
13 viral genome replication GO:0019079 9.58 CCL2 GAS6
14 positive regulation of MAP kinase activity GO:0043406 9.58 EDN1 FGF2 PDGFD
15 dendritic cell differentiation GO:0097028 9.56 AXL GAS6
16 enzyme linked receptor protein signaling pathway GO:0007167 9.55 AXL GAS6
17 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.54 AXL GAS6
18 cellular response to hydrogen peroxide GO:0070301 9.54 AXL IL6 PDGFD
19 cellular response to interferon-alpha GO:0035457 9.52 AXL GAS6
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.5 EDN1 IL6 PDGFD
21 positive regulation of natural killer cell differentiation GO:0032825 9.49 AXL GAS6
22 negative regulation of dendritic cell apoptotic process GO:2000669 9.48 AXL GAS6
23 fusion of virus membrane with host plasma membrane GO:0019064 9.46 CCR5 GAS6
24 cellular response to lipopolysaccharide GO:0071222 9.46 AXL CCL2 CCR5 IL6
25 protein kinase B signaling GO:0043491 9.43 AXL CCL2 GAS6
26 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.35 AXL CCL2 FGF2 GAS6 PDGFD
27 regulation of signaling receptor activity GO:0010469 9.1 CCL2 EDN1 FGF2 GAS6 IL6 PDGFD

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylserine binding GO:0001786 9.16 AXL GAS6
2 growth factor activity GO:0008083 9.13 FGF2 IL6 PDGFD
3 cytokine activity GO:0005125 8.92 CCL2 EDN1 FGF2 IL6

Sources for Mesangial Proliferative Glomerulonephritis

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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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