MCID: MSN001
MIFTS: 45

Mesangial Proliferative Glomerulonephritis

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Mesangial Proliferative Glomerulonephritis

MalaCards integrated aliases for Mesangial Proliferative Glomerulonephritis:

Name: Mesangial Proliferative Glomerulonephritis 12 52 15 71
Glomerulonephritis - Mesangial Proliferative 52
Glomerulonephritis Mesangial Proliferative 54
Mesangioproliferative Glomerulonephritis 52
Mesangial Proliferative Gn 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4783
NCIt 49 C35445
SNOMED-CT 67 35546006
UMLS 71 C0221238

Summaries for Mesangial Proliferative Glomerulonephritis

NIH Rare Diseases : 52 Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. Many experts consider it a variant of minimal change disease , but some experts believe it is a separate condition. It may present with nephrotic syndrome , which is a group of symptoms that include protein in the urine (proteinuria ), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. It can also present with blood in the urine (hematuria). MPGN is characterized by an increased number of mesangial cells in the glomeruli in the kidneys and damage to the glomeruli. Glomeruli are the structures that help filter wastes and fluids. MPGN may occur in several renal diseases such as IgA nephropathy (commonly), IgM nephropathy , lupus nephritis , and C1q nephropathy . However, in some cases, the underlying cause of MPGN remains unclear. Treatment may depend on the cause (if known) and may include steroids, mycophenolate mofetil , and/or cyclophosphamide , and other therapies to treat specific symptoms. Most people with MPGN have a good prognosis , but some may develop chronic kidney disease , which can progress to end stage renal failure .

MalaCards based summary : Mesangial Proliferative Glomerulonephritis, also known as glomerulonephritis - mesangial proliferative, is related to glomerulonephritis and glomerular disease. An important gene associated with Mesangial Proliferative Glomerulonephritis is IL6 (Interleukin 6), and among its related pathways/superpathways are PEDF Induced Signaling and ERK Signaling. The drugs Losartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Mesangial proliferative glomerulonephritis is a form of glomerulonephritis associated primarily with the... more...

Related Diseases for Mesangial Proliferative Glomerulonephritis

Diseases related to Mesangial Proliferative Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 31.0 FN1 CD79A CD40LG CCL2
2 glomerular disease 31.0 CD79A CCL2
3 proliferative glomerulonephritis 30.6 THY1 TGFB1I1 PDGFD IL6 EDN1 CCR5
4 proteasome-associated autoinflammatory syndrome 1 30.5 IL6 CCL3 CCL2
5 immune-complex glomerulonephritis 30.4 CD40LG CCR5 CCR1
6 lipoid nephrosis 30.3 CD79A CD40LG CCL2
7 q fever 30.3 IL6 CD40LG CCL2
8 interstitial lung disease 30.3 IL6 EDN1 CD40LG CCL2
9 takayasu arteritis 30.1 IL6 EDN1 CD40LG
10 c1q nephropathy 30.1 CD79A CD40LG
11 pulmonary disease, chronic obstructive 30.1 IL6 CCR5 CCL3 CCL2
12 purpura 30.0 IL6 CD79A CD40LG
13 acute poststreptococcal glomerulonephritis 29.9 EDN1 CD79A CD40LG
14 vasculitis 29.8 IL6 CD79A CD40LG CCL2
15 pulmonary hypertension 29.7 IL6 FN1 FGF2 EDN1 CCL2
16 connective tissue disease 29.4 IL6 FN1 EDN1 CD40LG CCL2
17 cryoglobulinemia 29.3 IL6 FN1 CD79A CD40LG
18 lung disease 29.1 IL6 FN1 EDN1 CD40LG CCR5 CCL3
19 dilated cardiomyopathy 28.8 MAPK1 IL6 FN1 EDN1 CD40LG CCL2
20 systemic lupus erythematosus 28.5 IL6 GAS6 CD79A CD40LG CCR5 CCR1
21 myeloma, multiple 28.5 IL6 FN1 FGF2 CD79A CD40LG CCL3
22 retinitis pigmentosa 26.6 THY1 SPG7 PTPRQ IL6 GAS6 FN1
23 c1q deficiency 11.6
24 nephrotic syndrome 10.8
25 genetic steroid-resistant nephrotic syndrome 10.8
26 iga glomerulonephritis 10.7
27 mesangioproliferative glomerulopathy 10.6
28 end stage renal failure 10.5
29 acute kidney failure 10.5
30 allergic encephalomyelitis 10.4 CCL3 CCL2
31 fuchs' heterochromic uveitis 10.4 IL6 CCL2
32 amyloidosis 10.4
33 palladium allergic contact dermatitis 10.4 CCL3 CCL2
34 whiplash 10.4 CCR5 CCL3
35 background diabetic retinopathy 10.4 IL6 EDN1 CCL2
36 retinal artery occlusion 10.4 THY1 IL6 CCL2
37 retinal vascular occlusion 10.4 IL6 EDN1 CCL2
38 stachybotrys chartarum 10.3 IL6 CCL3 CCL2
39 diabetic macular edema 10.3 IL6 FGF2 CCL2
40 chronic eosinophilic pneumonia 10.3 IL6 CCL3 CCL2
41 radiculopathy 10.3 IL6 CCL3 CCL2
42 carpal tunnel syndrome 10.3 IL6 FGF2 CCL2
43 membranous nephropathy 10.3
44 membranoproliferative glomerulonephritis 10.3
45 kidney disease 10.3
46 immunoglobulin alpha deficiency 10.3
47 alexithymia 10.3 IL6 CCR5 CCL3
48 osteosclerotic myeloma 10.3 IL6 CD40LG
49 periapical granuloma 10.3 CCR5 CCL3 CCL2
50 microvascular complications of diabetes 1 10.3 FGF2 EDN1 CCL2

Graphical network of the top 20 diseases related to Mesangial Proliferative Glomerulonephritis:



Diseases related to Mesangial Proliferative Glomerulonephritis

Symptoms & Phenotypes for Mesangial Proliferative Glomerulonephritis

MGI Mouse Phenotypes related to Mesangial Proliferative Glomerulonephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 AXL CCR1 CCR5 CD40LG EDN1 FGF2
2 homeostasis/metabolism MP:0005376 10.07 AXL CCR1 CCR5 CD40LG CD79A EDN1
3 hematopoietic system MP:0005397 10.02 AXL CCR1 CCR5 CD40LG CD79A FGF2
4 liver/biliary system MP:0005370 9.7 AXL CCR1 CCR5 CD79A FN1 IL6
5 neoplasm MP:0002006 9.5 CCR5 CD79A FGF2 FN1 IL6 MAPK1
6 nervous system MP:0003631 9.4 AXL CCR5 CD40LG CD79A EDN1 FGF2

Drugs & Therapeutics for Mesangial Proliferative Glomerulonephritis

Drugs for Mesangial Proliferative Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Losartan Approved Phase 4 114798-26-4 3961
2
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
3
Ramipril Approved Phase 4 87333-19-5 5362129
4 Antihypertensive Agents Phase 4
5 Anti-Arrhythmia Agents Phase 4
6 HIV Protease Inhibitors Phase 4
7
protease inhibitors Phase 4
8 Serine Proteinase Inhibitors Phase 4
9 Giapreza Phase 4
10 Vasoconstrictor Agents Phase 4
11 Angiotensin II Type 1 Receptor Blockers Phase 4
12 Immunoglobulin A Phase 4
13 Angiotensin-Converting Enzyme Inhibitors Phase 4
14 Angiotensin Receptor Antagonists Phase 4
15 Angiotensinogen Phase 4
16
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
17 Immunosuppressive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Treatment by Inhibitors of Angiotensin II at Low Doses in Non-nephrotic Proteinuric Patients With Pauciimmune and IgA Mesangioproliferative Glomerulonephritis Completed NCT01115426 Phase 4 Ramipril or losartan
2 Clinical Significance of Assesment of Serum miRNA-30a in Childhood Nephrotic Syndrome Unknown status NCT03235128
3 Retrospective Analysis of Renal Prognosis in Patients With Chronic Kidney Disease Unknown status NCT03201406

Search NIH Clinical Center for Mesangial Proliferative Glomerulonephritis

Genetic Tests for Mesangial Proliferative Glomerulonephritis

Anatomical Context for Mesangial Proliferative Glomerulonephritis

MalaCards organs/tissues related to Mesangial Proliferative Glomerulonephritis:

40
Kidney, T Cells, Lung, Monocytes, Endothelial, Neutrophil, Cortex

Publications for Mesangial Proliferative Glomerulonephritis

Articles related to Mesangial Proliferative Glomerulonephritis:

(show top 50) (show all 1270)
# Title Authors PMID Year
1
[Expression of MCP-1 in renal tissues of patients with IgA nephropathy]. 54 61
19893256 2009
2
Significance of plasma von Willebrand factor level and von Willebrand factor-cleaving protease activity in patients with chronic renal diseases. 54 61
18272039 2008
3
Immunopathogenesis of IgAN. 54 61
17851660 2007
4
Interleukin-6 gene polymorphism and faster progression to end-stage renal failure in chronic glomerulonephritis. 54 61
17656329 2007
5
Familial aggregation of primary glomerulonephritis in an Italian population isolate: Valtrompia study. 54 61
16528253 2006
6
CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. 54 61
16334979 2005
7
[Mesangial proliferative glomerulonephritis]. 54 61
15500128 2004
8
Staphylococcus aureus antigens induce IgA-type glomerulonephritis in Balb/c mice. 54 61
15372411 2004
9
Detection of nuclear factor-kappaB in IgA nephropathy using Southwestern histochemistry. 54 61
12830459 2003
10
Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. 54 61
12633573 2002
11
Differential effects of circulating IgA isolated from patients with IgA nephropathy on superoxide and fibronectin production of mesangial cells. 54 61
11423751 2001
12
Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis. 54 61
11290560 2001
13
Complement activation through the lectin pathway in patients with Henoch-Schönlein purpura nephritis. 54 61
10692265 2000
14
Renal synthesis of leukaemia inhibitory factor (LIF), under normal and inflammatory conditions. 54 61
10704254 2000
15
Renal pathology and HIV infection in Thailand. 54 61
10023639 1999
16
Glomerulonephritis associated with basaloid squamous cell carcinoma of the oesophagus. A possible unusual paraneoplastic syndrome. 54 61
9561579 1998
17
Castleman's disease and mesangial proliferative glomerulonephritis: the role of interleukin-6. 54 61
9546694 1998
18
[Haemophilus parainfluenzae antigens in IgA nephropathy]. 54 61
9492534 1998
19
Immunohistochemical localization of latent transforming growth factor-beta binding protein in IgA nephropathy. 54 61
9407453 1997
20
Glomerular Fc alphaR expression and disease activity in IgA nephropathy. 54 61
9292568 1997
21
Phenotypic characterization of cytokine expression in patients with IgA nephropathy. 54 61
9327339 1997
22
[Pathogenesis of IgA nephropathy: role of outer membranes of Haemophilus parainfluenzae antigens]. 54 61
9200951 1997
23
Von Willebrand factor abnormalities in IgA nephropathy. 54 61
9075127 1997
24
Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice. 54 61
9000479 1997
25
Pan-nephritis (glomerulonephritis, arteriolitis, and tubulointerstitial nephritis) associated with predominant mesangial C1q deposition and hypocomplementemia: a variant type of C1q nephropathy? 54 61
8678071 1996
26
In situ hybridization of interleukin 6 in diabetic nephropathy. 54 61
7556963 1995
27
Coexisting IgA nephropathy and leukocytoclastic cutaneous vasculitis associated with ankylosing spondylitis: a case report. 54 61
7712401 1995
28
Significance of high levels of serum IgA and IgA-class circulating immune complexes (IgA-CIC) in patients with non-insulin-dependent diabetes mellitus. 54 61
7734743 1995
29
Binding capacity of serum IgA to jacalin in patients with IgA nephropathy using jacalin-coated microplates. 54 61
7477622 1995
30
Increased mRNA encoding for transforming factor-beta in CD4+ cells from patients with IgA nephropathy. 54 61
7996808 1994
31
An immunohistochemical study of extracellular matrix components and integrins in human glomerular diseases. 54 61
8022108 1994
32
Primary glomerulonephritis with detectable glomerular hepatitis B virus antigens. 54 61
8291656 1994
33
[Diseases associated with cytokine dysregulation]. 54 61
8371004 1993
34
Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis. 54 61
8468929 1993
35
[Interleukin 6 (IL-6)]. 54 61
1491446 1992
36
Detection and clinical usefulness of urinary interleukin-6 in the diseases of the kidney and the urinary tract. 54 61
1424304 1992
37
The evidence for interleukin-6 as an autocrine growth factor in malignancy. 54 61
1643291 1992
38
[Studies on Hanganutziu-Deicher antibodies in renal diseases]. 54 61
1316976 1992
39
Induction of interleukin 6 synthesis in mouse glomeruli and cultured mesangial cells. 54 61
1436293 1992
40
Urinary IL-6: a marker for mesangial proliferative glomerulonephritis? 54 61
1914227 1991
41
The prognostic significance of urinary interleukin 6 in IgA nephropathy. 54 61
2007290 1991
42
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. 61
31943786 2020
43
Case report on mesangial proliferative glomerulonephritis with multicentric Castleman's disease: Approach to the onset mechanism of immunoglobulin A nephropathy. 61
31978558 2020
44
D-site binding protein regulates cell proliferation through mediating cell cycle progression in rat mesangial cells. 61
31759405 2019
45
TGF-β1 inhibits the autophagy of podocytes by activating mTORC1 in IgA nephropathy. 61
31600491 2019
46
Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China. 61
31198075 2019
47
HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy. 61
31243235 2019
48
The effectiveness of chitosan-mediated silencing of PDGF-B and PDGFR-β in the mesangial proliferative glomerulonephritis therapy. 61
31265815 2019
49
PC-1 NF suppresses high glucose-stimulated inflammation and extracellular matrix accumulation in glomerular mesangial cells via the Wnt/β-catenin signaling. 61
31410160 2019
50
The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis. 61
29568121 2019

Variations for Mesangial Proliferative Glomerulonephritis

Expression for Mesangial Proliferative Glomerulonephritis

Search GEO for disease gene expression data for Mesangial Proliferative Glomerulonephritis.

Pathways for Mesangial Proliferative Glomerulonephritis

Pathways related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 MAPK1 IL6 EDN1 CD40LG CCR5 CCR1
2
Show member pathways
13.54 TGFB1I1 PDGFD MAPK1 IL6 GAS6 FN1
3
Show member pathways
13.49 PDGFD MAPK1 IL6 GAS6 FGF2 CCL3
4
Show member pathways
13.35 THY1 MAPK1 FN1 CCR5 CCR1 CCL3
5
Show member pathways
13.27 PDGFD MAPK1 IL6 GAS6 FGF2 CD79A
6
Show member pathways
13.21 PDGFD IL6 GAS6 FGF2 CD40LG CCR5
7
Show member pathways
13.2 MAPK1 IL6 FN1 FGF2 CD40LG CCR5
8
Show member pathways
12.96 PDGFD MAPK1 IL6 GAS6 FN1 FGF2
9
Show member pathways
12.94 PDGFD MAPK1 IL6 GAS6 FGF2 CCL2
10
Show member pathways
12.83 TGFB1I1 MAPK1 CCR5 CCR1 CCL3 CCL2
11
Show member pathways
12.82 MAPK1 IL6 FGF2 CCR5 CCR1 CCL3
12 12.79 MAPK1 IL6 FN1 FGF2 EDN1
13
Show member pathways
12.76 PTPRQ PDGFD MAPK1 IL6 GAS6 FGF2
14
Show member pathways
12.66 PDGFD IL6 GAS6 FGF2 CD40LG
15
Show member pathways
12.54 MAPK1 IL6 FN1 FGF2 CCL2
16
Show member pathways
12.49 PDGFD MAPK1 IL6 GAS6 FGF2 AXL
17
Show member pathways
12.31 PDGFD MAPK1 IL6 GAS6 FGF2 AXL
18
Show member pathways
12.23 IL6 CCR5 CCR1 CCL3 CCL2
19 11.96 MAPK1 IL6 FN1 CCL2
20 11.94 THY1 IL6 CD79A CCR1
21 11.93 IL6 FN1 FGF2 CCL2
22 11.91 MAPK1 IL6 EDN1 CCL2
23 11.87 MAPK1 IL6 FN1 CCL3
24 11.86 MAPK1 IL6 CCR5 CCR1
25 11.82 IL6 CCL3 CCL2
26 11.8 MAPK1 IL6 FN1 EDN1 CCL2
27 11.74 MAPK1 IL6 CCL3
28 11.69 IL6 CCL3 CCL2
29 11.69 PDGFD MAPK1 IL6 GAS6 FGF2
30
Show member pathways
11.63 MAPK1 IL6 CD40LG
31 11.52 IL6 FGF2 EDN1 CCL3 CCL2
32 11.51 IL6 CD40LG CCL2
33 11.49 THY1 IL6 FN1
34 11.46 MAPK1 FN1 FGF2
35 11.43 PDGFD MAPK1 FGF2
36 11.24 IL6 CCR5 CCR1 CCL3 CCL2
37 10.23 PDGFD MAPK1 IL6 GAS6 FN1 FGF2

GO Terms for Mesangial Proliferative Glomerulonephritis

Cellular components related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 PDGFD IL6 GAS6 FN1 FGF2 EDN1
2 extracellular region GO:0005576 9.7 THY1 PDGFD MAPK1 IL6 GAS6 FN1
3 external side of plasma membrane GO:0009897 9.65 THY1 CD79A CD40LG CCR5 CCR1
4 endoplasmic reticulum lumen GO:0005788 9.62 PDGFD IL6 GAS6 FN1
5 cell GO:0005623 9.32 THY1 MAPK1 IL6 GAS6 FGF2 EDN1

Biological processes related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 MAPK1 IL6 GAS6 FGF2 CD40LG CCR5
2 cell adhesion GO:0007155 10.06 THY1 TGFB1I1 GAS6 FN1 CCR1 CCL2
3 positive regulation of gene expression GO:0010628 10.05 MAPK1 IL6 GAS6 FN1 CCL3
4 positive regulation of cell proliferation GO:0008284 10.03 PDGFD MAPK1 IL6 FN1 FGF2 EDN1
5 immune response GO:0006955 10.02 IL6 CD40LG CCR5 CCR1 CCL3 CCL2
6 angiogenesis GO:0001525 9.98 THY1 FN1 FGF2 CCL2
7 MAPK cascade GO:0000165 9.93 MAPK1 FGF2 CCR5 CCL3 CCL2
8 cellular response to lipopolysaccharide GO:0071222 9.92 IL6 CCR5 CCL2 AXL
9 positive regulation of cell migration GO:0030335 9.92 PDGFD MAPK1 EDN1 CCR1 CCL3
10 positive regulation of protein kinase B signaling GO:0051897 9.91 GAS6 FGF2 CCL3 AXL
11 cell surface receptor signaling pathway GO:0007166 9.91 EDN1 CD79A CCR5 CCR1 CCL2
12 cellular response to tumor necrosis factor GO:0071356 9.88 MAPK1 EDN1 CCL3 CCL2
13 cell-cell signaling GO:0007267 9.88 THY1 EDN1 CCR5 CCR1 CCL3
14 cellular response to interferon-gamma GO:0071346 9.87 EDN1 CCL3 CCL2
15 neutrophil chemotaxis GO:0030593 9.86 EDN1 CCL3 CCL2
16 cellular response to interleukin-1 GO:0071347 9.86 EDN1 CCL3 CCL2
17 cellular response to hydrogen peroxide GO:0070301 9.84 PDGFD IL6 AXL
18 positive regulation of MAP kinase activity GO:0043406 9.82 PDGFD FGF2 EDN1
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 PDGFD IL6 EDN1
20 sensory perception of pain GO:0019233 9.8 MAPK1 EDN1 CCL2
21 cell chemotaxis GO:0060326 9.8 CCR5 CCR1 CCL3 CCL2
22 positive regulation of fibroblast proliferation GO:0048146 9.79 PDGFD GAS6 FN1
23 substrate adhesion-dependent cell spreading GO:0034446 9.77 TGFB1I1 FN1 AXL
24 monocyte chemotaxis GO:0002548 9.77 IL6 CCL3 CCL2
25 calcium-mediated signaling GO:0019722 9.76 EDN1 CCR5 CCR1 CCL3
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 MAPK1 CCL3 CCL2
27 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 PDGFD GAS6 FGF2 CCR1 CCL3 CCL2
28 platelet activation GO:0030168 9.72 MAPK1 IL6 GAS6 CD40LG AXL
29 chemokine-mediated signaling pathway GO:0070098 9.71 CCR5 CCR1 CCL3 CCL2
30 macrophage chemotaxis GO:0048246 9.7 CCL3 CCL2
31 inflammatory response GO:0006954 9.7 IL6 CD40LG CCR5 CCR1 CCL3 CCL2
32 viral genome replication GO:0019079 9.69 GAS6 CCL2
33 dendritic cell differentiation GO:0097028 9.69 GAS6 AXL
34 cellular response to interferon-alpha GO:0035457 9.68 GAS6 AXL
35 response to cholesterol GO:0070723 9.68 CCR5 CCL3
36 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.67 GAS6 AXL
37 signaling GO:0023052 9.67 CCR5 CCL3
38 protein kinase B signaling GO:0043491 9.67 GAS6 CCL3 CCL2 AXL
39 positive regulation of natural killer cell differentiation GO:0032825 9.66 GAS6 AXL
40 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.66 CCR5 CCL3
41 enzyme linked receptor protein signaling pathway GO:0007167 9.65 GAS6 AXL
42 negative regulation of dendritic cell apoptotic process GO:2000669 9.64 GAS6 AXL
43 fusion of virus membrane with host plasma membrane GO:0019064 9.64 GAS6 CCR5
44 astrocyte cell migration GO:0043615 9.63 CCL3 CCL2
45 chemotaxis GO:0006935 9.43 MAPK1 FGF2 CCR5 CCR1 CCL3 CCL2
46 cytokine-mediated signaling pathway GO:0019221 9.17 IL6 FN1 FGF2 CCR5 CCR1 CCL3

Molecular functions related to Mesangial Proliferative Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.19 THY1 TGFB1I1 SPG7 PTPRQ MAPK1 IL6
2 integrin binding GO:0005178 9.46 THY1 FN1 FGF2 CD40LG
3 cytokine activity GO:0005125 9.1 IL6 FGF2 EDN1 CD40LG CCL3 CCL2
4 chemokine (C-C motif) ligand 5 binding GO:0071791 8.96 CCR5 CCR1

Sources for Mesangial Proliferative Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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