MCID: MSN004
MIFTS: 42

Mesenchymal Cell Neoplasm

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Mesenchymal Cell Neoplasm

MalaCards integrated aliases for Mesenchymal Cell Neoplasm:

Name: Mesenchymal Cell Neoplasm 12 15 71
Benign Miscellaneous Mesenchymal Tumor 12
Mesenchymal Tumors 15
Mesenchymal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3350
NCIt 50 C6587 C7059
UMLS 71 C1332517 C1334699

Summaries for Mesenchymal Cell Neoplasm

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

MalaCards based summary : Mesenchymal Cell Neoplasm, also known as benign miscellaneous mesenchymal tumor, is related to malignant mesenchymoma and central nervous system mesenchymal non-meningothelial tumor. An important gene associated with Mesenchymal Cell Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are G-protein signaling RAC1 in cellular process and Pathways in cancer. The drugs Ponatinib and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and colon, and related phenotypes are integument and no phenotypic analysis

Related Diseases for Mesenchymal Cell Neoplasm

Diseases related to Mesenchymal Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 517)
# Related Disease Score Top Affiliating Genes
1 malignant mesenchymoma 32.6 SERPINA3 MYOG CD34 CALD1
2 central nervous system mesenchymal non-meningothelial tumor 32.2 MYOG EWSR1
3 benign fibrous mesothelioma 32.2 KIT CD34 ALK
4 paraganglioma and gastric stromal sarcoma 32.1 PDGFRA KIT CD34 ANO1
5 inflammatory myofibroblastic tumor 31.4 TPM3 RANBP2 NTRK3 KIT EML4 CD68
6 rare tumor 31.1 KIT EWSR1
7 endometrial stromal sarcoma 30.8 ZC3H7B PDGFRA KIT EWSR1 CALD1
8 fibrosarcoma 30.7 PDGFRA NTRK3 KIT EWSR1 ALK
9 intravenous leiomyomatosis 30.7 HMGA2 CD34 CALD1
10 reticulosarcoma 30.7 SERPINA3 CD68 ALK
11 fibroma 30.7 SERPINA3 CD68 CD34
12 embryonal sarcoma 30.7 SERPINA3 MYOG KIT
13 rhabdomyosarcoma 30.6 PDGFRA MYOG KIT HMGA2 EWSR1 ALK
14 fibrous histiocytoma 30.6 SERPINA3 KIT EWSR1 CD68 CD34 ALK
15 sarcoma 30.6 PDGFRA MYOG KIT EWSR1 ALK
16 clear cell sarcoma 30.6 MLANA KIT EWSR1
17 chondrosarcoma, extraskeletal myxoid 30.5 MYOG EWSR1 CD34
18 pleomorphic liposarcoma 30.5 SERPINA3 PDGFRA KIT EWSR1 CALD1
19 pleomorphic lipoma 30.5 SERPINA3 HMGA2 CD68 CD34
20 myofibroma 30.5 SERPINA3 CD34 CALD1
21 dermatofibrosarcoma protuberans 30.5 SERPINA3 PDGFRA KIT HMGA2 CD34
22 rhabdomyosarcoma 2 30.5 MYOG EWSR1 ALK
23 cutaneous fibrous histiocytoma 30.4 SERPINA3 MLANA CD68 CD34
24 endometrial stromal nodule 30.4 ZC3H7B CALD1
25 myxoid leiomyosarcoma 30.4 ZC3H7B CALD1
26 liposarcoma 30.4 PDGFRA MYOG HMGA2 EWSR1 CD68 CD34
27 neurofibroma 30.3 PDGFRA MLANA KIT CD34
28 gastrointestinal stromal tumor 30.3 PDGFRA NTRK3 MIR518A1 KIT CD34 ANO1
29 spindle cell sarcoma 30.3 SERPINA3 NTRK3 MYOG KIT EWSR1 CD34
30 perineurioma 30.3 PDGFRA KIT ALK
31 gastric liposarcoma 30.3 KIT CD34 ANO1
32 amelanotic melanoma 30.3 SERPINA3 MLANA KIT
33 intussusception 30.2 KIT CD34 ANO1
34 angiolipoma 30.2 MLANA CD34 CALD1
35 glomus tumor 30.2 KIT CD34 CALD1
36 extraskeletal mesenchymal chondrosarcoma 30.2 NAB2 EWSR1
37 mastocytosis 30.2 PDGFRA NTRK3 KIT
38 congenital fibrosarcoma 30.2 TPM3 SERPINA3 NTRK3 MYOG EWSR1 ALK
39 lipomatosis, multiple 30.2 SERPINA3 MLANA KIT HMGA2 EWSR1 CD34
40 benign breast phyllodes tumor 30.2 KIT CD34
41 nasal cavity benign neoplasm 30.2 NAB2 KIT CD34
42 endometrial stromal tumor 30.2 ZC3H7B EWSR1 CALD1
43 smooth muscle tumor 30.2 SERPINA3 KIT HMGA2 CD34 CALD1 ANO1
44 leiomyosarcoma 30.2 ZC3H7B SERPINA3 PDGFRA MYOG MLANA KIT
45 infantile myofibromatosis 30.2 NTRK3 CD34 CALD1
46 chondroma 30.1 PDGFRA KIT HMGA2 ANO1
47 malignant fibrous histiocytoma 30.1 SERPINA3 MYOG KIT EWSR1 CD68
48 tenosynovial giant cell tumor 30.1 SERPINA3 KIT CD68 CD34
49 neuroma 30.1 SERPINA3 CD68 CD34
50 connective tissue benign neoplasm 30.1 SERPINA3 MLANA KIT EWSR1 CD68 CD34

Graphical network of the top 20 diseases related to Mesenchymal Cell Neoplasm:



Diseases related to Mesenchymal Cell Neoplasm

Symptoms & Phenotypes for Mesenchymal Cell Neoplasm

MGI Mouse Phenotypes related to Mesenchymal Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.85 ALK ANO1 CD34 FGF23 KIT MLANA
2 no phenotypic analysis MP:0003012 9.5 CD68 KIT MLANA MYOG NTRK3 PDGFRA
3 respiratory system MP:0005388 9.23 ALK ANO1 FGF23 KIT MYOG NAB2

Drugs & Therapeutics for Mesenchymal Cell Neoplasm

Drugs for Mesenchymal Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ponatinib Approved, Investigational Phase 2 943319-70-8 24826799
2
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
5 Protein Kinase Inhibitors Phase 2
6 Antibiotics, Antitubercular Phase 2
7 Anti-Bacterial Agents Phase 2
8
Liposomal doxorubicin Phase 2 31703
9
Somatostatin Approved, Investigational Early Phase 1 51110-01-1, 38916-34-6 53481605
10
Phenylalanine Approved, Investigational, Nutraceutical Early Phase 1 63-91-2 6140
11 Pharmaceutical Solutions Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Following Failure of Prior Tyrosine Kinase Inhibitor Therapy Completed NCT01874665 Phase 2 Ponatinib
2 High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum Completed NCT00592345 Phase 1, Phase 2
3 Phase II Study Evaluating PegLiposomal Doxorubicin (PLD) and Carboplatin Combination Chemotherapy in Gynecological Sarcomas and Mixed Epithelial-Mesenchymal Tumors Completed NCT00815945 Phase 2 PegLiposomal Doxorubicin;Carboplatin
4 68Ga-DOTATATE PET for Localization of Phosphaturic Mesenchymal Tumors in Patients With Tumor Induced Osteomalacia Recruiting NCT03736564 Phase 1, Phase 2
5 Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore): A Prospective Randomized, Controlled Multicenter Study Withdrawn NCT02766842 Phase 2
6 68Ga-DOTATATE PET/CT for Detection and Evaluation of the Causative Tumor of Oncogenic Osteomalacia Unknown status NCT01524016 Early Phase 1 68Ga-DOTATATE
7 Selective Venous Catheterization for the Localization of Phosphaturic Mesenchymal Tumors Completed NCT00099762

Search NIH Clinical Center for Mesenchymal Cell Neoplasm

Genetic Tests for Mesenchymal Cell Neoplasm

Anatomical Context for Mesenchymal Cell Neoplasm

MalaCards organs/tissues related to Mesenchymal Cell Neoplasm:

40
Uterus, Smooth Muscle, Colon, Pancreas, Small Intestine, Lymph Node, Prostate

Publications for Mesenchymal Cell Neoplasm

Articles related to Mesenchymal Cell Neoplasm:

(show top 50) (show all 2734)
# Title Authors PMID Year
1
Hiding in plain sight: Gene panel and genetic markers reveal 26-year undiagnosed tumor-induced osteomalacia of the rib concurrently misdiagnosed as X-linked hypophosphatemia. 61
33490314 2021
2
Fibroma-like perivascular epithelioid cell tumor: a rare case in a long bone. 61
32944815 2021
3
Coexistence of Conventional Leiomyoma, Fumarate Hydratase-deficient Atypical Leiomyoma, and Perivascular Epithelioid Cell Tumor in a Uterus: A Case Study. 61
32265359 2021
4
Minimally invasive options for gastrointestinal stromal tumors of the stomach. 61
32221752 2021
5
Right Hepatectomy with Vascular and Biliary Reconstruction for a Portal Vein Leiomyosarcoma. 61
32909126 2021
6
Imaging of the Middle and Visceral Mediastinum. 61
33551081 2021
7
Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor? 61
33578901 2021
8
Myxoma complicated acute intestinal obstruction: A rare case with diagnostic challenges. 61
33605922 2021
9
Hypophosphatemia and FGF23 tumor-induced osteomalacia in two cases of metastatic breast cancer. 61
33191899 2021
10
Low-grade chondrosarcoma mimicking breast cancer. 61
33131290 2021
11
Stiffness increases with myofibroblast content and collagen density in mesenchymal high grade serous ovarian cancer. 61
33603134 2021
12
A Population-based Analysis of Lymph Node Metastasis in Extremity Soft Tissue Sarcoma: An Update. 61
33561723 2021
13
Primary sarcomas of the spine: population-based demographic and survival data in 107 spinal sarcomas over a 23-year period in Ontario, Canada. 61
32949731 2021
14
Expression of lymphoid enhancer-binding factor 1 in breast fibroepithelial lesions. 61
33245988 2021
15
"A hybrid approach for GISTs near the esophagogastric junction, a case report". 61
33537145 2021
16
Endoscopic ultrasound-guided fine needle aspiration cytology diagnosis of upper gastrointestinal tract mesenchymal tumors: Impact of rapid onsite evaluation and correlation with histopathologic follow-up. 61
33006819 2021
17
Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors. 61
33559990 2021
18
A Case of Inv(1)(q23q31) TPR-NTRK1 Fusion-Positive Spindle Cell Neoplasm in an Infant-Uncovered by Next-Generation Sequencing: Diagnostic Challenge, Review, and Therapeutic Implications. 61
32489127 2021
19
Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review. 61
33543674 2021
20
[Uterine malignant perivascular epithelioid cell tumor (PEComa): Two case reports]. 61
32646778 2021
21
Primary perivascular epithelioid cell tumor (PEComa) in bone: A review of the literature and a case arising in the humerus with multiple metastases. 61
33240785 2021
22
Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions. 61
32860002 2021
23
Ultrasonography in infectious and neoplastic diseases of the bowel and peritoneum. 61
33608108 2021
24
Ameloblastic Fibroodontoma of Mandible Causing Tumor Induced Osteomalacia: A Case Report with Review of 88 Phosphaturic Oral Neoplasms. 61
33394371 2021
25
Nasal hemangiopericytoma presenting with oncogenic osteomalasia: A case report and literature review. 61
33446319 2021
26
Osteolipoma: a review of the literature and a rare case report. 61
33428104 2021
27
Perforation of intestinal leiomyosarcoma: A case report. 61
33498000 2021
28
Gastrointestinal Stromal Tumors (GISTs): Novel Therapeutic Strategies with Immunotherapy and Small Molecules. 61
33419029 2021
29
Mesenchymal tumors of the gastrointestinal tract with NTRK rearrangements: a clinicopathological, immunophenotypic, and molecular study of eight cases, emphasizing their distinction from gastrointestinal stromal tumor (GIST). 61
32669612 2021
30
Near-infrared fluorescence-guided metastasectomy for hepatic gastrointestinal stromal tumor metastases using indocyanine green: A case report. 61
33360978 2021
31
Surgical Management of Sarcoma Metastatic to Liver. 61
33220809 2021
32
Unusual presentations, management and outcomes of gastric stromal tumors: a single-center case series. 61
33414618 2021
33
Update on Molecular Genetics of Gastrointestinal Stromal Tumors. 61
33525726 2021
34
Tumor-Induced Osteomalacia. 61
32504138 2021
35
Genomic Profiling Aids Classification of Diagnostically Challenging Uterine Mesenchymal Tumors With Myomelanocytic Differentiation. 61
32889887 2021
36
Application of ultrasound-guided biopsy and percutaneous radiofrequency ablation in 2 cases with phosphaturic mesenchymal tumor and literature review. 61
32924995 2021
37
Epstein-Barr Virus-Associated Post-transplant Lymphoproliferative Disease. 61
33200367 2021
38
FOXO1 gene involvement in a non-rhabdomyosarcomatous neoplasm. 61
33506328 2021
39
A late systemic and brain metastasis from subcutaneous leiomyosarcoma of the right forearm: a case report and review of the literature. 61
33461603 2021
40
A combined radiomics and clinical variables model for prediction of malignancy in T2 hyperintense uterine mesenchymal tumors on MRI. 61
33486606 2021
41
Extragastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass: Case Report. 61
33603400 2021
42
The Outcome of Neoadjuvant Imatinib Therapy Combined With Surgery for Rectal Gastrointestinal Stromal Tumors: A Report of Three Cases and a Review of the Literature. 61
33489517 2020
43
Gastric Schwannoma in an elderly man: A case report. 61
33361729 2020
44
Cancer genomics of lung cancer including malignant mesothelioma: A brief overview of current status and future prospects. 61
32992231 2020
45
Inhibitors of cytoskeletal dynamics in malignant mesothelioma. 61
33400741 2020
46
Supportive care needs and quality of care of patients with lung cancer in Mexico: A cross-sectional study. 61
33120212 2020
47
Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. 61
32920118 2020
48
Burosumab for the Treatment of Tumor-Induced Osteomalacia. 61
33338281 2020
49
Intracranial Myxoid Mesenchymal Tumor/Myxoid Subtype Angiomatous Fibrous Histiocytoma: Diagnostic and Prognostic Challenges. 61
32970137 2020
50
Clinical Characteristics and Surgical Outcomes of Sinonasal Lesions Associated With Tumor-Induced Osteomalacia. 61
33290165 2020

Variations for Mesenchymal Cell Neoplasm

Expression for Mesenchymal Cell Neoplasm

Search GEO for disease gene expression data for Mesenchymal Cell Neoplasm.

Pathways for Mesenchymal Cell Neoplasm

Pathways related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.85 PDGFRA NTRK3 KIT FGF23 ALK
2 11.83 TPM3 PDGFRA KIT FGF23 EML4 ALK
3 11.48 MYOG KIT CD34
4 10.98 PDGFRA NTRK3 KIT
5 10.56 PDGFRA NTRK3 KIT FGF23 ALK
6 10.51 PDGFRA FGF23

GO Terms for Mesenchymal Cell Neoplasm

Cellular components related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 PDGFRA NTRK3 MLANA KIT CD34 ANO1
2 receptor complex GO:0043235 8.92 PDGFRA NTRK3 KIT ALK

Biological processes related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.87 PDGFRA NTRK3 MYOG KIT HMGA2 ANO1
2 positive regulation of gene expression GO:0010628 9.77 NTRK3 KIT HMGA2 FGF23 CD34
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 PDGFRA NTRK3 KIT
4 peptidyl-tyrosine phosphorylation GO:0018108 9.56 PDGFRA NTRK3 KIT ALK
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.46 PDGFRA NTRK3 KIT ALK
6 positive regulation of kinase activity GO:0033674 9.26 PDGFRA NTRK3 KIT ALK
7 positive regulation of phospholipase C activity GO:0010863 8.8 PDGFRA NTRK3 KIT

Molecular functions related to Mesenchymal Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 ZC3H7B TPM3 SERPINA3 RANBP2 PDGFRA NTRK3
2 protein tyrosine kinase activity GO:0004713 9.26 PDGFRA NTRK3 KIT ALK
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 PDGFRA NTRK3 KIT ALK

Sources for Mesenchymal Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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