MCID: MSN005
MIFTS: 40

Mesenchymal Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 15 17
Chondrosarcoma, Mesenchymal 45 74
Chondrosarcoma Mesenchymal 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 45 D018211
NCIt 51 C3737
SNOMED-CT 69 56565002
UMLS 74 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondromyxoid fibroma and adult mesenchymal chondrosarcoma, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Cyclophosphamide and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cellular and embryo

Wikipedia : 77 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 chondromyxoid fibroma 29.6 DES SOX9 VIM
2 adult mesenchymal chondrosarcoma 12.6
3 extraskeletal mesenchymal chondrosarcoma 12.5
4 pediatric mesenchymal chondrosarcoma 12.3
5 chondrosarcoma 11.1
6 periosteal chondrosarcoma 10.3 HEY1 NCOA2
7 cutaneous leiomyosarcoma 10.2 DES MUC1
8 spindle cell thymoma 10.2 DES MUC1
9 ischemic fasciitis 10.2 DES MUC1
10 fasciitis 10.2 DES MUC1
11 proximal spinal muscular atrophy 10.2 DES MUC1
12 plasmablastic lymphoma 10.2 DES MUC1
13 liposarcoma 10.2 DES VIM
14 infantile digital fibromatosis 10.2 DES VIM
15 fibromatosis 10.2 DES VIM
16 lymphangiomatosis 10.1 DES VIM
17 angiolipoma 10.1 DES VIM
18 primitive neuroectodermal tumor of the cervix uteri 10.1 DES VIM
19 leiomyosarcoma 10.1 DES VIM
20 spindle cell lipoma 10.1 DES VIM
21 epulis 10.1 DES VIM
22 epithelioid leiomyosarcoma 10.1 DES VIM
23 benign metastasizing leiomyoma 10.1 DES VIM
24 cystic nephroma 10.1 DES VIM
25 juvenile xanthogranuloma 10.1 DES VIM
26 cutaneous fibrous histiocytoma 10.1 DES VIM
27 fibrous histiocytoma 10.1 DES VIM
28 congenital fibrosarcoma 10.1 DES VIM
29 malignant peritoneal mesothelioma 10.1 MUC1 VIM
30 papillary tumor of the pineal region 10.1 MUC1 VIM
31 pseudosarcomatous fibromatosis 10.1 DES VIM
32 secretory meningioma 10.1 MUC1 VIM
33 fibrous meningioma 10.1 MUC1 VIM
34 chordoid meningioma 10.1 MUC1 VIM
35 glomus tumor 10.1 DES VIM
36 nodular hidradenoma 10.1 MUC1 VIM
37 hidradenoma 10.1 MUC1 VIM
38 clear cell ependymoma 10.1 MUC1 VIM
39 ependymoma 10.1 MUC1 VIM
40 eccrine porocarcinoma 10.1 MUC1 VIM
41 granular cell tumor 10.1 DES VIM
42 endometrial mucinous adenocarcinoma 10.1 MUC1 VIM
43 adenofibroma 10.1 MUC1 VIM
44 clear cell meningioma 10.1 MUC1 VIM
45 myxopapillary ependymoma 10.1 MUC1 VIM
46 monophasic synovial sarcoma 10.1 MUC1 VIM
47 embryonal sarcoma 10.1 DES VIM
48 spindle cell rhabdomyosarcoma 10.1 DES MUC1 NCOA2
49 smooth muscle tumor 10.1 DES VIM
50 anaplastic ependymoma 10.1 MUC1 VIM

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 CDX1 DES HEY1 NCOA2 SOX9 VIM
2 embryo MP:0005380 9.1 CDX1 HEY1 IRF2BP2 NCOA2 SOX9 VIM

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
2
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
4
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Antineoplastic Agents, Alkylating Phase 2, Phase 3
8 Alkylating Agents Phase 2, Phase 3
9 Antibiotics, Antitubercular Phase 2, Phase 3
10
Isophosphamide mustard Phase 2, Phase 3 0
11 Topoisomerase Inhibitors Phase 2, Phase 3
12
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
14
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
15 Immunologic Factors Phase 2
16 Antifungal Agents Phase 2
17 Antirheumatic Agents Phase 2
18 Immunosuppressive Agents Phase 2
19 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

42
Bone, Kidney, Lung, Pancreas, Heart, Spleen, Cerebellum

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 340)
# Title Authors Year
1
Mesenchymal chondrosarcoma of maxilla in paediatric patient. ( 30852518 )
2019
2
Robot-assisted radical nephrectomy for primary renal mesenchymal chondrosarcoma: case report and literature review. ( 30909775 )
2019
3
Periosteal mesenchymal chondrosarcoma of the tibia. ( 29397433 )
2018
4
Mesenchymal chondrosarcoma of the orbit: Imaging features of CT and MRI. ( 29975155 )
2018
5
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 29332118 )
2018
6
Mesenchymal Chondrosarcoma of the Lacrimal Gland. ( 29342030 )
2018
7
Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case. ( 29972855 )
2018
8
Mesenchymal Chondrosarcoma of the Orbit Attached to the Optic Nerve. ( 29863559 )
2018
9
Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases. ( 29755276 )
2018
10
Intracranial Mesenchymal Chondrosarcoma: Report of 16 Cases. ( 29783007 )
2018
11
18F-FDG PET/CT Findings of Mesenchymal Chondrosarcoma of the Orbit. ( 29215408 )
2018
12
Primary mesenchymal chondrosarcoma of the kidney: A case report and review of literature. ( 29893343 )
2018
13
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion. ( 29596896 )
2018
14
Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology. ( 29582189 )
2018
15
Response to: Periosteal mesenchymal chondrosarcoma of the tibia. ( 29473108 )
2018
16
Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma. ( 30327751 )
2018
17
Primary orbital mesenchymal chondrosarcoma. ( 30340745 )
2018
18
Extraskeletal Mesenchymal Chondrosarcoma. ( 30407856 )
2018
19
The Differences between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes. ( 30415056 )
2018
20
Mesenchymal chondrosarcoma of the parapharyngeal space. ( 30488876 )
2018
21
Mesenchymal chondrosarcoma metastasising to the pancreas. ( 30598468 )
2018
22
Extraskeletal orbital mesenchymal chondrosarcoma: surgical approach and mini review. ( 28258179 )
2017
23
Mesenchymal chondrosarcoma of the orbit: A case report with 5A years of follow-up. ( 28812954 )
2017
24
Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients. ( 29044531 )
2017
25
Intraspinal mesenchymal chondrosarcoma: report of a pediatric case and literature review. ( 29143958 )
2017
26
Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Clinical Mimicry as Glomus Jugulare. ( 28867901 )
2017
27
Extraskeletal mesenchymal chondrosarcoma at unusual location involving spleen and kidney with review of literature. ( 28631650 )
2017
28
Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. ( 28479701 )
2017
29
What Is Your Diagnosis? Extraskeletal mesenchymal chondrosarcoma. ( 28857701 )
2017
30
Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report. ( 28271053 )
2017
31
A Huge Mass in a Boy's Chest: An Unusual Case of Mesenchymal Chondrosarcoma. ( 29229475 )
2017
32
Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28352960 )
2017
33
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 28917072 )
2017
34
Primary Spinal Intradural Mesenchymal Chondrosarcoma with Several Local Regrowths Treated with Osteoplastic Laminotomies: A Case Report. ( 28825035 )
2017
35
Erratum to: Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28389822 )
2017
36
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
37
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
38
Expert's comment concerning Grand Rounds case entitled "Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma" (Chang-Hwa Lee and Woo-Kie Min); Eur Spine J (2015): DOI 10.1007/s00586-015-4297-z. ( 27048539 )
2016
39
Spontaneous Intraventricular Hemorrhage: A Rare Presentation of a Skull Base Mesenchymal Chondrosarcoma. ( 28042016 )
2016
40
Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. ( 27617402 )
2016
41
CORR Insights(Ar): Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 27048221 )
2016
42
Mesenchymal chondrosarcoma of mandible. ( 27721626 )
2016
43
Spinal extraosseous intradural mesenchymal chondrosarcoma. ( 27012648 )
2016
44
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
45
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case. ( 28164050 )
2016
46
Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature. ( 27487949 )
2016
47
Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 26975384 )
2016
48
Pancreatic Involvement by Mesenchymal Chondrosarcoma Harboring the HEY1-NCOA2 Gene Fusion. ( 27544802 )
2016
49
Extraskeletal mesenchymal chondrosarcoma arising in adductor magnus with metastatic foci. ( 30364375 )
2016
50
Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years. ( 25849226 )
2015

Variations for Mesenchymal Chondrosarcoma

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 DES MUC1 VIM
2 11.11 DES VIM
3 10.92 CDX1 SOX9 VIM
4
Show member pathways
10.61 DES VIM

GO Terms for Mesenchymal Chondrosarcoma

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 CDX1 DES HEY1 IRF2BP2 MUC1 NCOA2

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.26 DES VIM
2 intermediate filament organization GO:0045109 9.16 DES VIM
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.02 CDX1 HEY1 IRF2BP2 NCOA2 SOX9
4 endocardial cushion morphogenesis GO:0003203 8.96 HEY1 SOX9

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 CDX1 HEY1 IRF2BP2

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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