MCID: MSN005
MIFTS: 36

Mesenchymal Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 15
Chondrosarcoma, Mesenchymal 44 73
Chondrosarcoma Mesenchymal 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 44 D018211
NCIt 50 C3737
SNOMED-CT 68 56565002
UMLS 73 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondromyxoid fibroma and adult mesenchymal chondrosarcoma, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Cyclophosphamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cellular and embryo

Wikipedia : 76 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 chondromyxoid fibroma 29.7 DES SOX9 VIM
2 adult mesenchymal chondrosarcoma 12.5
3 extraskeletal mesenchymal chondrosarcoma 12.5
4 pediatric mesenchymal chondrosarcoma 12.3
5 chondrosarcoma 11.1
6 periosteal chondrosarcoma 10.2 HEY1 NCOA2
7 spindle cell thymoma 10.2 DES MUC1
8 ischemic fasciitis 10.1 DES MUC1
9 proximal spinal muscular atrophy 10.1 DES MUC1
10 plasmablastic lymphoma 10.1 DES MUC1
11 liposarcoma 10.1 DES VIM
12 infantile digital fibromatosis 10.1 DES VIM
13 fibromatosis 10.1 DES VIM
14 lymphangiomatosis 10.1 DES VIM
15 angiolipoma 10.1 DES VIM
16 primitive neuroectodermal tumor of the cervix uteri 10.1 DES VIM
17 cutaneous leiomyosarcoma 10.1 DES VIM
18 leiomyosarcoma 10.1 DES VIM
19 spindle cell lipoma 10.1 DES VIM
20 epulis 10.1 DES VIM
21 epithelioid leiomyosarcoma 10.1 DES VIM
22 benign metastasizing leiomyoma 10.1 DES VIM
23 cystic nephroma 10.1 DES VIM
24 juvenile xanthogranuloma 10.1 DES VIM
25 cutaneous fibrous histiocytoma 10.1 DES VIM
26 fibrous histiocytoma 10.1 DES VIM
27 congenital fibrosarcoma 10.1 DES VIM
28 malignant peritoneal mesothelioma 10.1 MUC1 VIM
29 papillary tumor of the pineal region 10.1 MUC1 VIM
30 pseudosarcomatous fibromatosis 10.1 DES VIM
31 secretory meningioma 10.1 MUC1 VIM
32 fibrous meningioma 10.1 MUC1 VIM
33 chordoid meningioma 10.1 MUC1 VIM
34 glomus tumor 10.1 DES VIM
35 nodular hidradenoma 10.1 MUC1 VIM
36 hidradenoma 10.1 MUC1 VIM
37 clear cell ependymoma 10.1 MUC1 VIM
38 ependymoma 10.1 MUC1 VIM
39 granular cell tumor 10.1 DES VIM
40 eccrine porocarcinoma 10.1 MUC1 VIM
41 endometrial mucinous adenocarcinoma 10.1 MUC1 VIM
42 bile duct adenoma 10.1 MUC1 VIM
43 adenofibroma 10.1 MUC1 VIM
44 clear cell meningioma 10.1 MUC1 VIM
45 myxopapillary ependymoma 10.1 MUC1 VIM
46 monophasic synovial sarcoma 10.1 MUC1 VIM
47 smooth muscle tumor 10.1 DES VIM
48 melanotic neuroectodermal tumor 10.0 MUC1 VIM
49 embryonal sarcoma 10.0 DES VIM
50 spindle cell rhabdomyosarcoma 10.0 DES MUC1 NCOA2

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 CDX1 DES HEY1 NCOA2 SOX9 VIM
2 embryo MP:0005380 9.1 CDX1 HEY1 IRF2BP2 NCOA2 SOX9 VIM

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
3
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
4
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Antineoplastic Agents, Alkylating Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Alkylating Agents Phase 2, Phase 3
10
Isophosphamide mustard Phase 2, Phase 3 0
11 Topoisomerase Inhibitors Phase 2, Phase 3
12
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
13
Everolimus Approved Phase 2 159351-69-6 6442177
14
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
15 Antirheumatic Agents Phase 2
16 Immunologic Factors Phase 2
17 Anti-Infective Agents Phase 2
18 Immunosuppressive Agents Phase 2
19 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

41
Bone, Kidney, Lung, Pancreas, Cervix, Smooth Muscle, Pineal

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 337)
# Title Authors Year
1
Periosteal mesenchymal chondrosarcoma of the tibia. ( 29397433 )
2018
2
Mesenchymal chondrosarcoma of the orbit: Imaging features of CT and MRI. ( 29975155 )
2018
3
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 29332118 )
2018
4
Mesenchymal Chondrosarcoma of the Lacrimal Gland. ( 29342030 )
2018
5
Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case. ( 29972855 )
2018
6
Mesenchymal Chondrosarcoma of the Orbit Attached to the Optic Nerve. ( 29863559 )
2018
7
Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases. ( 29755276 )
2018
8
Intracranial Mesenchymal Chondrosarcoma: Report of 16 Cases. ( 29783007 )
2018
9
18F-FDG PET/CT Findings of Mesenchymal Chondrosarcoma of the Orbit. ( 29215408 )
2018
10
Primary mesenchymal chondrosarcoma of the kidney: A case report and review of literature. ( 29893343 )
2018
11
Minute Mesenchymal Chondrosarcoma within Osteochondroma: An Unexpected Diagnosis Confirmed by HEY1-NCOA2 Fusion. ( 29596896 )
2018
12
Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology. ( 29582189 )
2018
13
Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma. ( 30327751 )
2018
14
Primary orbital mesenchymal chondrosarcoma. ( 30340745 )
2018
15
Extraskeletal Mesenchymal Chondrosarcoma. ( 30407856 )
2018
16
The Differences between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes. ( 30415056 )
2018
17
Mesenchymal chondrosarcoma of the parapharyngeal space. ( 30488876 )
2018
18
Response to: Periosteal mesenchymal chondrosarcoma of the tibia. ( 29473108 )
2018
19
Extraskeletal orbital mesenchymal chondrosarcoma: surgical approach and mini review. ( 28258179 )
2017
20
Mesenchymal chondrosarcoma of the orbit: A case report with 5A years of follow-up. ( 28812954 )
2017
21
Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients. ( 29044531 )
2017
22
Intraspinal mesenchymal chondrosarcoma: report of a pediatric case and literature review. ( 29143958 )
2017
23
Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Clinical Mimicry as Glomus Jugulare. ( 28867901 )
2017
24
Extraskeletal mesenchymal chondrosarcoma at unusual location involving spleen and kidney with review of literature. ( 28631650 )
2017
25
Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. ( 28479701 )
2017
26
What Is Your Diagnosis? Extraskeletal mesenchymal chondrosarcoma. ( 28857701 )
2017
27
Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report. ( 28271053 )
2017
28
A Huge Mass in a Boy's Chest: An Unusual Case of Mesenchymal Chondrosarcoma. ( 29229475 )
2017
29
Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28352960 )
2017
30
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 28917072 )
2017
31
Primary Spinal Intradural Mesenchymal Chondrosarcoma with Several Local Regrowths Treated with Osteoplastic Laminotomies: A Case Report. ( 28825035 )
2017
32
Erratum to: Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28389822 )
2017
33
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
34
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
35
Expert's comment concerning Grand Rounds case entitled "Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma" (Chang-Hwa Lee and Woo-Kie Min); Eur Spine J (2015): DOI 10.1007/s00586-015-4297-z. ( 27048539 )
2016
36
Spontaneous Intraventricular Hemorrhage: A Rare Presentation of a Skull Base Mesenchymal Chondrosarcoma. ( 28042016 )
2016
37
Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. ( 27617402 )
2016
38
CORR Insights(Ar): Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 27048221 )
2016
39
Mesenchymal chondrosarcoma of mandible. ( 27721626 )
2016
40
Spinal extraosseous intradural mesenchymal chondrosarcoma. ( 27012648 )
2016
41
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
42
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case. ( 28164050 )
2016
43
Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature. ( 27487949 )
2016
44
Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 26975384 )
2016
45
Pancreatic Involvement by Mesenchymal Chondrosarcoma Harboring the HEY1-NCOA2 Gene Fusion. ( 27544802 )
2016
46
Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma. ( 26556438 )
2016
47
Extraskeletal mesenchymal chondrosarcoma arising in adductor magnus with metastatic foci. ( 30364375 )
2016
48
Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years. ( 25849226 )
2015
49
Imaging features of extraskeletal mesenchymal chondrosarcoma of the hand. ( 25797212 )
2015
50
Intraparenchymal mesenchymal chondrosarcoma of the frontal lobe - a case report and molecular detection of specific gene fusions from archival FFPE sample. ( 25907264 )
2015

Variations for Mesenchymal Chondrosarcoma

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 DES MUC1 VIM
2 11.11 DES VIM
3 10.92 CDX1 SOX9 VIM
4
Show member pathways
10.61 DES VIM

GO Terms for Mesenchymal Chondrosarcoma

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 CDX1 DES HEY1 IRF2BP2 MUC1 NCOA2

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.26 DES VIM
2 intermediate filament organization GO:0045109 9.16 DES VIM
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.02 CDX1 HEY1 IRF2BP2 NCOA2 SOX9
4 endocardial cushion morphogenesis GO:0003203 8.96 HEY1 SOX9

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 CDX1 HEY1 IRF2BP2

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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