MCID: MSN005
MIFTS: 40

Mesenchymal Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 15 17
Chondrosarcoma, Mesenchymal 45 74
Chondrosarcoma Mesenchymal 56

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 45 D018211
NCIt 51 C3737
SNOMED-CT 69 56565002
UMLS 74 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to hemangiopericytoma, malignant and chondromyxoid fibroma, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cellular and embryo

Wikipedia : 77 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 hemangiopericytoma, malignant 29.7 DES MUC1 VIM
2 chondromyxoid fibroma 29.6 DES SOX9 VIM
3 adult mesenchymal chondrosarcoma 12.6
4 extraskeletal mesenchymal chondrosarcoma 12.5
5 pediatric mesenchymal chondrosarcoma 12.4
6 chondrosarcoma 11.1
7 periosteal chondrosarcoma 10.3 HEY1 NCOA2
8 cutaneous leiomyosarcoma 10.2 DES MUC1
9 spindle cell thymoma 10.2 DES MUC1
10 ischemic fasciitis 10.2 DES MUC1
11 fasciitis 10.2 DES MUC1
12 proximal spinal muscular atrophy 10.2 DES MUC1
13 plasmablastic lymphoma 10.2 DES MUC1
14 liposarcoma 10.2 DES VIM
15 infantile digital fibromatosis 10.2 DES VIM
16 fibromatosis 10.2 DES VIM
17 lymphangiomatosis 10.2 DES VIM
18 angiolipoma 10.2 DES VIM
19 primitive neuroectodermal tumor of the cervix uteri 10.2 DES VIM
20 leiomyosarcoma 10.1 DES VIM
21 spindle cell lipoma 10.1 DES VIM
22 epulis 10.1 DES VIM
23 epithelioid leiomyosarcoma 10.1 DES VIM
24 benign metastasizing leiomyoma 10.1 DES VIM
25 cystic nephroma 10.1 DES VIM
26 juvenile xanthogranuloma 10.1 DES VIM
27 degos 'en cocarde' erythrokeratoderma 10.1
28 cutaneous fibrous histiocytoma 10.1 DES VIM
29 fibrous histiocytoma 10.1 DES VIM
30 congenital fibrosarcoma 10.1 DES VIM
31 malignant peritoneal mesothelioma 10.1 MUC1 VIM
32 papillary tumor of the pineal region 10.1 MUC1 VIM
33 pseudosarcomatous fibromatosis 10.1 DES VIM
34 secretory meningioma 10.1 MUC1 VIM
35 fibrous meningioma 10.1 MUC1 VIM
36 chordoid meningioma 10.1 MUC1 VIM
37 glomus tumor 10.1 DES VIM
38 nodular hidradenoma 10.1 MUC1 VIM
39 hidradenoma 10.1 MUC1 VIM
40 clear cell ependymoma 10.1 MUC1 VIM
41 ependymoma 10.1 MUC1 VIM
42 eccrine porocarcinoma 10.1 MUC1 VIM
43 granular cell tumor 10.1 DES VIM
44 endometrial mucinous adenocarcinoma 10.1 MUC1 VIM
45 adenofibroma 10.1 MUC1 VIM
46 clear cell meningioma 10.1 MUC1 VIM
47 myxopapillary ependymoma 10.1 MUC1 VIM
48 monophasic synovial sarcoma 10.1 MUC1 VIM
49 embryonal sarcoma 10.1 DES VIM
50 spindle cell rhabdomyosarcoma 10.1 DES MUC1 NCOA2

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 CDX1 DES HEY1 NCOA2 SOX9 VIM
2 embryo MP:0005380 9.1 CDX1 HEY1 IRF2BP2 NCOA2 SOX9 VIM

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
4
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
5
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
6
Doxil Approved June 1999 Phase 2, Phase 3 31703
7 Antineoplastic Agents, Alkylating Phase 2, Phase 3
8 Anti-Bacterial Agents Phase 2, Phase 3
9 Antibiotics, Antitubercular Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Topoisomerase Inhibitors Phase 2, Phase 3
12
Isophosphamide mustard Phase 2, Phase 3 0
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 5284616 6436030
14
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
15
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
16 Anti-Infective Agents Phase 2
17 Immunologic Factors Phase 2
18 Antirheumatic Agents Phase 2
19 Immunosuppressive Agents Phase 2
20 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
2 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

42
Bone, Kidney, Lung, Pancreas, Heart, Spleen, Cerebellum

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 344)
# Title Authors Year
1
Mesenchymal chondrosarcoma of maxilla in paediatric patient. ( 30852518 )
2019
2
Robot-assisted radical nephrectomy for primary renal mesenchymal chondrosarcoma: case report and literature review. ( 30909775 )
2019
3
Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case. ( 29972855 )
2019
4
The Differences Between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes. ( 30415056 )
2019
5
Mesenchymal chondrosarcoma metastasising to the pancreas. ( 30598468 )
2018
6
Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology. ( 29582189 )
2018
7
Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion. ( 29596896 )
2018
8
Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases. ( 29755276 )
2018
9
Intracranial Mesenchymal Chondrosarcoma: Report of 16 Cases. ( 29783007 )
2018
10
Mesenchymal Chondrosarcoma of the Orbit Attached to the Optic Nerve. ( 29863559 )
2018
11
Primary mesenchymal chondrosarcoma of the kidney: A case report and review of literature. ( 29893343 )
2018
12
Mesenchymal chondrosarcoma of the orbit: imaging features of CT and MRI. ( 29975155 )
2018
13
Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma. ( 30327751 )
2018
14
Primary orbital mesenchymal chondrosarcoma. ( 30340745 )
2018
15
Extraskeletal Mesenchymal Chondrosarcoma. ( 30407856 )
2018
16
Mesenchymal chondrosarcoma of the parapharyngeal space. ( 30488876 )
2018
17
Mesenchymal chondrosarcoma of the orbit: A case report with 5 years of follow-up. ( 28812954 )
2018
18
18F-FDG PET/CT Findings of Mesenchymal Chondrosarcoma of the Orbit. ( 29215408 )
2018
19
A Huge Mass in a Boy's Chest: An Unusual Case of Mesenchymal Chondrosarcoma. ( 29229475 )
2018
20
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 29332118 )
2018
21
Mesenchymal Chondrosarcoma of the Lacrimal Gland. ( 29342030 )
2018
22
Periosteal mesenchymal chondrosarcoma of the tibia. ( 29397433 )
2018
23
Response to: Periosteal mesenchymal chondrosarcoma of the tibia. ( 29473108 )
2018
24
Clinicopathological and histological behavior of mesenchymal chondrosarcoma involving maxilla. ( 28479701 )
2017
25
Extraskeletal mesenchymal chondrosarcoma at unusual location involving spleen and kidney with review of literature. ( 28631650 )
2017
26
Primary Spinal Intradural Mesenchymal Chondrosarcoma with Several Local Regrowths Treated with Osteoplastic Laminotomies: A Case Report. ( 28825035 )
2017
27
What Is Your Diagnosis? Extraskeletal mesenchymal chondrosarcoma. ( 28857701 )
2017
28
Primary Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Clinical Mimicry as Glomus Jugulare. ( 28867901 )
2017
29
Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. ( 28917072 )
2017
30
Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients. ( 29044531 )
2017
31
Intraspinal mesenchymal chondrosarcoma: report of a pediatric case and literature review. ( 29143958 )
2017
32
Spontaneous Intraventricular Hemorrhage: A Rare Presentation of a Skull Base Mesenchymal Chondrosarcoma. ( 28042016 )
2017
33
Extraskeletal orbital mesenchymal chondrosarcoma: surgical approach and mini review. ( 28258179 )
2017
34
Renal Extra Skeletal Mesenchymal Chondrosarcoma: A Case Report. ( 28271053 )
2017
35
Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28352960 )
2017
36
Erratum to: Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: a case report. ( 28389822 )
2017
37
Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 26975384 )
2017
38
CORR Insights®: Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database. ( 27048221 )
2017
39
Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma. ( 27418251 )
2016
40
Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature. ( 27487949 )
2016
41
Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion. ( 27544802 )
2016
42
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
43
Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. ( 27617402 )
2016
44
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
45
Mesenchymal chondrosarcoma of mandible. ( 27721626 )
2016
46
Extraskeletal Mesenchymal Chondrosarcoma of Shoulder: An Extremely Rare Case. ( 28164050 )
2016
47
Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma. ( 26556438 )
2016
48
Spinal extraosseous intradural mesenchymal chondrosarcoma. ( 27012648 )
2016
49
Expert's comment concerning Grand Rounds case entitled "Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma" (Chang-Hwa Lee and Woo-Kie Min); Eur Spine J (2015): DOI 10.1007/s00586-015-4297-z. ( 27048539 )
2016
50
Extraskeletal mesenchymal chondrosarcoma arising in adductor magnus with metastatic foci. ( 30364375 )
2016

Variations for Mesenchymal Chondrosarcoma

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 DES MUC1 VIM
2 11.11 DES VIM
3 10.92 CDX1 SOX9 VIM
4
Show member pathways
10.61 DES VIM

GO Terms for Mesenchymal Chondrosarcoma

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.23 CDX1 DES HEY1 IRF2BP2 MUC1 NCOA2

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.26 DES VIM
2 intermediate filament organization GO:0045109 9.16 DES VIM
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.02 CDX1 HEY1 IRF2BP2 NCOA2 SOX9
4 endocardial cushion morphogenesis GO:0003203 8.96 HEY1 SOX9

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 CDX1 HEY1 IRF2BP2

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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