MCID: MSN005
MIFTS: 46

Mesenchymal Chondrosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 15 17
Chondrosarcoma, Mesenchymal 44 70
Chondrosarcoma Mesenchymal 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 44 D018211
NCIt 50 C3737
SNOMED-CT 67 56565002
UMLS 70 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to chondrosarcoma and small cell osteogenic sarcoma, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyclophosphamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related phenotypes are cellular and embryo

Wikipedia : 73 A bone sarcoma is a primary malignant bone tumour, a type of sarcoma that starts in the bones. This is... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 420)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 31.2 VIM SOX9 PDGFRA NCOA2 MUC1 ENO2
2 small cell osteogenic sarcoma 30.6 SYP ENO2
3 meningioma, familial 30.3 VIM SYP SMARCB1 MUC1
4 hemangiopericytoma, malignant 30.3 VIM SYP MYOG MUC1 ENO2 DES
5 myxoid chondrosarcoma 30.2 SYP SMARCB1 MUC1
6 osteochondroma 30.2 VIM NCOA2 HEY1
7 reticulum cell sarcoma 30.2 VIM MUC1 DES
8 dedifferentiated liposarcoma 30.2 MYOG MUC1 DES
9 sarcomatoid mesothelioma 30.2 VIM MUC1 DES
10 chondromyxoid fibroma 30.1 VIM SOX9 DES
11 extraosseous chondrosarcoma 30.1 SYP SMARCB1 ENO2
12 fibrous histiocytoma 30.1 VIM ENO2 DES
13 secretory meningioma 30.0 VIM SMARCB1 MUC1 KRT7
14 chondrosarcoma, extraskeletal myxoid 29.8 SYP SMARCB1 MYOG ENO2
15 embryonal sarcoma 29.8 VIM MYOG MYOD1 DES
16 liposarcoma 29.7 VIM PDGFRA MYOG DES
17 pleomorphic adenoma 29.7 VIM MUC1 KRT7 DES
18 monophasic synovial sarcoma 29.7 VIM MUC1 KRT7
19 ewing sarcoma 29.6 VIM SYP PDGFRA MYOG ENO2 DES
20 sarcoma 29.6 VIM SMARCB1 PDGFRA MYOG MUC1
21 spindle cell sarcoma 29.5 VIM NCOA2 MYOG MUC1 KRT7 DES
22 hemangioma 29.1 VIM SYP MUC1 KRT7 ENO2
23 teratoma 29.1 SYP SMARCB1 KRT7 ENO2
24 sarcoma, synovial 29.0 VIM SMARCB1 MYOG MUC1 KRT7 DES
25 neurilemmoma 28.9 VIM SMARCB1 PDGFRA MUC1 ENO2 DES
26 papilloma of choroid plexus 28.9 SYP SMARCB1 MUC1 KRT7 ENO2
27 cavernous hemangioma 28.9 VIM SYP PDGFRA MUC1 KRT7 DES
28 renal cell carcinoma, nonpapillary 28.7 VIM PDGFRA MUC1 KRT7 ENO2
29 medulloblastoma 28.6 VIM SYP SOX9 SMARCB1 PDGFRA ENO2
30 rhabdomyosarcoma 27.6 VIM SYP SMARCB1 PDGFRA NCOA2 MYOG
31 adult mesenchymal chondrosarcoma 11.5
32 extraskeletal mesenchymal chondrosarcoma 11.5
33 pediatric mesenchymal chondrosarcoma 11.3
34 rare tumor 10.6
35 exophthalmos 10.5
36 choriocarcinoma of ovary 10.4 NCOA2 HEY1
37 spinal canal intradural extramedullary neoplasm 10.4 NCOA2 HEY1
38 intracranial meningioma 10.4
39 lymphoplasmacyte-rich meningioma 10.4
40 infantile digital fibromatosis 10.4 VIM DES
41 myocardium cancer 10.4 SYP MYOG
42 esophageal neuroendocrine tumor 10.4 SYP MUC1
43 vulvar eccrine porocarcinoma 10.4 SYP MUC1
44 lymphangiomatosis 10.4 VIM DES
45 cervical polyp 10.4 MYOG DES
46 lung combined type small cell carcinoma 10.4 SYP MYOG
47 syringocystadenoma papilliferum 10.3 MUC1 DES
48 nodular hidradenoma 10.3 VIM MUC1
49 heart lymphoma 10.3 VIM MYOG
50 endometrial mucinous adenocarcinoma 10.3 VIM MUC1

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CDX1 DES ENO2 HEY1 KRT7 MYOG
2 embryo MP:0005380 9.96 CDX1 HEY1 IRF2BP2 MYOG NCOA2 NKX3-1
3 muscle MP:0005369 9.76 DES HEY1 MYOD1 MYOG PDGFRA SMARCB1
4 no phenotypic analysis MP:0003012 9.43 MYOD1 MYOG NCOA2 NKX3-1 PDGFRA SOX9
5 normal MP:0002873 9.23 CDX1 HEY1 MYOD1 MYOG PDGFRA SOX9

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
3
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
4
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
5
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
6 Alkylating Agents Phase 2, Phase 3
7 Antibiotics, Antitubercular Phase 2, Phase 3
8 Anti-Bacterial Agents Phase 2, Phase 3
9
Isophosphamide mustard Phase 2, Phase 3 100427
10
Liposomal doxorubicin Phase 2, Phase 3 31703
11
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
12
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
14
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
15 Antirheumatic Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Immunologic Factors Phase 2
18 Antifungal Agents Phase 2
19 Anti-Infective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754) Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
2 A Phase 2, Single Arm, Multi Center Trial Evaluating the Efficacy of the COmbination of Sirolimus and cYclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and chOndrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 SARC024: A Blanket Protocol to Study Oral Regorafenib in Patients With Selected Sarcoma Subtypes Recruiting NCT02048371 Phase 2 Regorafenib;Placebo
4 A Phase 2 Study of GDC-0449 in Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib
5 Phase II Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma Not yet recruiting NCT04305548 Phase 2 Trabectedin

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

40
Bone, Lung, Breast, Prostate, Appendix, Pineal, Kidney

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 595)
# Title Authors PMID Year
1
Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. 54 61
20123451 2010
2
[Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue]. 54 61
17068623 2006
3
Desmin and myogenin reactivity in mesenchymal chondrosarcoma: a potential diagnostic pitfall. 61 54
16405671 2006
4
Congenital mesenchymal chondrosarcoma of the orbit: case report and review of the literature. 61 54
15121382 2004
5
The impact of osteonectin for differential diagnosis of osteogenic bone tumors: an immunohistochemical and in situ hybridization approach. 61 54
8717113 1996
6
Confirmation of NKX3-1 Expression in EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma Using Monoclonal Antibody Immunohistochemistry, RT-PCR, and RNA In Situ Hybridization. 61
33443863 2021
7
18F-FDG PET/CT Imaging of Pancreatic and Adrenal Metastases in a Patient With Mesenchymal Chondrosarcoma. 61
33323740 2021
8
Nuclear expression of DDIT3 distinguishes high-grade myxoid liposarcoma from other round cell sarcomas. 61
33731886 2021
9
NKX3.1 immunohistochemistry is highly specific for the diagnosis of mesenchymal chondrosarcomas: experience in the Australian population. 61
33640159 2021
10
NKX3.1 a useful marker for mesenchymal chondrosarcoma: An immunohistochemical study. 61
33302222 2021
11
Heavily calcified parapharyngeal space mesenchymal chondrosarcoma: Imaging and pathological findings and a review of the literature. 61
32998632 2021
12
Intracranial extra-axial mesenchymal chondrosarcoma in a 16-month-old patient with a literature review of pediatric patients. 61
32382867 2021
13
Chondrosarcoma. 61
33595238 2021
14
Mesenchymal Chondrosarcoma in the Maxilla: A Case Report and Literature Review. 61
33773967 2021
15
Mesenchymal chondrosarcoma: imaging features and clinical findings. 61
32734374 2021
16
Primary Spinal Intradural Extramedullary Mesenchymal Chondrosarcoma. 61
33049384 2021
17
NKX3.1 immunoreactivity is not identified in mesenchymal chondrosarcoma: a 25-case cohort study. 61
32779239 2021
18
Mesenchymal Chondrosarcoma-A Retrospective study. 61
33716213 2021
19
Rare tumors in pediatric age group: Single center experience from Saudi Arabia. 61
33708364 2021
20
Utility of NKX3.1 immunohistochemistry in the differential diagnosis of seminal vesicles versus prostatic tissue in needle biopsy. 61
33126153 2020
21
NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker. 61
32327700 2020
22
How Does the Skeletal Oncology Research Group Algorithm's Prediction of 5-year Survival in Patients with Chondrosarcoma Perform on International Validation? 61
32433107 2020
23
Metastasectomy of left atrial mesenchymal chondrosarcoma. 61
32413904 2020
24
OLIG2 Immunolabeling of Mesenchymal Chondrosarcoma: Report of 14 Cases. 61
32770197 2020
25
Mesenchymal chondrosarcoma of the orbit masquerading as a hemophilic pseudotumor. 61
32835558 2020
26
Mesenchymal chondrosarcoma - A rare cause of pleural effusion. 61
32724019 2020
27
[Detection and analysis of HEY1-NCOA2 fusion gene in mesenchymal chondrosarcoma]. 61
32486542 2020
28
NKX3-1 Is a Useful Immunohistochemical Marker of EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma. 61
31972596 2020
29
Primary intraocular mesenchymal chondrosarcoma: a histopathological surprise in an enucleated eye. 61
31874712 2020
30
Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials. 61
32220056 2020
31
Sarcoma metastasis to the pancreas: experience at a single institution. 61
32311873 2020
32
Mesenchymal Chondrosarcoma of the Brain with Metastasis: A Case Report with Literature Review. 61
32367992 2020
33
Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by HEY1-NCOA2 Gene Fusion. 61
32322450 2020
34
Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features. 61
32257101 2020
35
[Maxillary mesenchymal chondrosarcoma: a case report]. 61
32193916 2020
36
[Cartilage tumors: morphology, genetics, and current aspects of target therapy]. 61
32060685 2020
37
Primary mesenchymal chondrosarcoma of the kidney without HEY1-NCOA2 and IRF2BP2-CDX1 fusion: A case report and review. 61
31897203 2020
38
Maxillary mesenchymal chondrosarcoma leading to a diagnosis of Li-Fraumeni syndrome. 61
31976063 2020
39
What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. 61
31701222 2020
40
Surgical treatment of metastatic mesenchymal chondrosarcoma to the spine: A case report. 61
32000368 2020
41
Paediatric High-Grade Intracranial Mesenchymal Chondrosarcoma: A Case Report with 6 Years of Follow-Up without Recurrence. 61
33152731 2020
42
Intraspinal mesenchymal chondrosarcoma: An argument for aggressive local resection and adjuvant therapy based on review of the literature. 61
33030461 2020
43
A challenging case of Mesenchymal Chondrosarcoma involving the thyroid and special considerations for diagnosis. 61
32180995 2020
44
[Clinical analysis of sinonasal chondrosarcoma in 47 cases]. 61
31954383 2020
45
Long lasting response with trabectedin monotherapy in relapsed metastatic mesenchymal chondrosarcoma. 61
32864096 2020
46
A rare and rapidly progressing renal chondrosarcoma: a case report. 61
32782706 2020
47
Ewing sarcoma and Ewing-like tumors. 61
31802230 2020
48
Robot-assisted radical nephrectomy for primary renal mesenchymal chondrosarcoma: case report and literature review. 61
30909775 2019
49
Primary intradural extramedullary spinal mesenchymal chondrosarcoma: case report and literature review. 61
31484514 2019
50
Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Case Report and Review of the Literature of Reported Cases in Adults and Children. 61
31158544 2019

Variations for Mesenchymal Chondrosarcoma

Cosmic variations for Mesenchymal Chondrosarcoma:

9 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM106056882 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
2 COSM111763021 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
3 COSM144313682 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
4 COSM105659131 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
5 COSM93187807 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
6 COSM143375075 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
7 COSM105624912 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
8 COSM122766413 TP53 soft tissue,upper leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
9 COSM145021980 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
10 COSM93215390 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
11 COSM143182864 TP53 soft tissue,upper leg,sarcoma,NS c.22C>T p.Q8* 17:7675113-7675113 3
12 COSM144334467 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
13 COSM143972614 TP53 soft tissue,upper leg,sarcoma,NS c.22C>T p.Q8* 17:7675113-7675113 3
14 COSM87902864 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
15 COSM112257156 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
16 COSM142564162 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
17 COSM144655779 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
18 COSM142840367 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
19 COSM122737959 TP53 soft tissue,upper leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
20 COSM144111084 TP53 soft tissue,upper leg,sarcoma,NS c.22C>T p.Q8* 17:7675113-7675113 3
21 COSM121881087 TP53 soft tissue,upper leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
22 COSM142860117 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
23 COSM144089819 TP53 soft tissue,upper leg,sarcoma,NS c.164A>G p.H55R 17:7674890-7674890 3
24 COSM144682712 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
25 COSM143159971 TP53 soft tissue,upper leg,sarcoma,NS c.164A>G p.H55R 17:7674890-7674890 3
26 COSM122275322 TP53 soft tissue,upper leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
27 COSM144041526 TP53 soft tissue,upper leg,sarcoma,NS c.466C>T p.Q156* 17:7675113-7675113 3
28 COSM142592590 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
29 COSM106084061 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
30 COSM112284809 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
31 COSM143401670 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
32 COSM122302302 TP53 soft tissue,upper leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
33 COSM143947426 TP53 soft tissue,upper leg,sarcoma,NS c.164A>G p.H55R 17:7674890-7674890 3
34 COSM144017515 TP53 soft tissue,upper leg,sarcoma,NS c.608A>G p.H203R 17:7674890-7674890 3
35 COSM121910283 TP53 soft tissue,upper leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
36 COSM111790424 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
37 COSM145045823 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
38 COSM87935416 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
39 COSM92479334 SH2B3 soft tissue,upper leg,sarcoma,NS c.232G>A p.E78K 12:111418377-111418377 3
40 COSM135372634 NUP93 soft tissue,upper leg,sarcoma,NS c.116C>T p.A39V 16:56748363-56748363 3
41 COSM88525472 NUP93 soft tissue,upper leg,sarcoma,NS c.116C>T p.A39V 16:56748363-56748363 3
42 COSM95516578 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
43 COSM95520543 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
44 COSM95523461 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
45 COSM95526780 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
46 COSM87494413 GNAQ soft tissue,bone,sarcoma,NS c.442C>T p.R148* 9:77815650-77815650 3
47 COSM98577250 ANKRD11 soft tissue,upper leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3
48 COSM87618826 ANKRD11 soft tissue,upper leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3
49 COSM147901996 ANKRD11 soft tissue,upper leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

GO Terms for Mesenchymal Chondrosarcoma

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 VIM SOX9 SMARCB1 PDGFRA NKX3-1 NCOA2
2 chromatin GO:0000785 9.28 SOX9 SMARCB1 NKX3-1 NCOA2 MYOG MYOD1

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10 PDGFRA NKX3-1 MYOG MYOD1 HEY1 CDX1
2 cell differentiation GO:0030154 9.93 SOX9 SMARCB1 NKX3-1 MYOG MYOD1 CDX1
3 regulation of transcription, DNA-templated GO:0006355 9.91 SOX9 NKX3-1 NCOA2 MYOG MYOD1 HEY1
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 SOX9 PDGFRA NKX3-1
5 positive regulation of transcription, DNA-templated GO:0045893 9.63 SOX9 NKX3-1 NCOA2 MYOG MYOD1 HEY1
6 intermediate filament organization GO:0045109 9.56 VIM DES
7 regulation of transcription by RNA polymerase II GO:0006357 9.56 SOX9 SMARCB1 NKX3-1 MYOG MYOD1 IRF2BP2
8 myoblast differentiation GO:0045445 9.55 MYOG MYOD1
9 endocardial cushion morphogenesis GO:0003203 9.54 SOX9 HEY1
10 prostate gland development GO:0030850 9.51 SOX9 NKX3-1
11 myotube differentiation GO:0014902 9.49 MYOG MYOD1
12 negative regulation of biomineral tissue development GO:0070168 9.43 SOX9 HEY1
13 positive regulation of skeletal muscle fiber development GO:0048743 9.4 MYOG MYOD1
14 muscle cell fate commitment GO:0042693 9.32 MYOG MYOD1
15 positive regulation of histone H4 acetylation GO:0090240 9.26 SMARCB1 MUC1
16 positive regulation of transcription by RNA polymerase II GO:0045944 9.23 SOX9 SMARCB1 NKX3-1 NCOA2 MYOG MYOD1

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.88 SOX9 NKX3-1 MYOG MYOD1 HEY1 CDX1
2 transcription factor binding GO:0008134 9.67 NKX3-1 NCOA2 MYOD1 HEY1
3 DNA-binding transcription factor activity GO:0003700 9.63 SOX9 NKX3-1 MYOG MYOD1 HEY1 CDX1
4 protein dimerization activity GO:0046983 9.56 NCOA2 MYOG MYOD1 HEY1
5 proximal promoter sequence-specific DNA binding GO:0000987 9.5 SOX9 MYOG MYOD1
6 sequence-specific double-stranded DNA binding GO:1990837 9.43 SOX9 NKX3-1 MYOG MYOD1 HEY1 CDX1
7 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.23 SOX9 NKX3-1 NCOA2 MYOG MYOD1 MUC1

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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