MCID: MSN005
MIFTS: 41

Mesenchymal Chondrosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Mesenchymal Chondrosarcoma

MalaCards integrated aliases for Mesenchymal Chondrosarcoma:

Name: Mesenchymal Chondrosarcoma 12 15 17
Chondrosarcoma, Mesenchymal 43 71
Chondrosarcoma Mesenchymal 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4545
MeSH 43 D018211
NCIt 49 C3737
SNOMED-CT 67 56565002
UMLS 71 C0206637

Summaries for Mesenchymal Chondrosarcoma

MalaCards based summary : Mesenchymal Chondrosarcoma, also known as chondrosarcoma, mesenchymal, is related to meningioma, radiation-induced and myxoid chondrosarcoma, and has symptoms including pain An important gene associated with Mesenchymal Chondrosarcoma is NCOA2 (Nuclear Receptor Coactivator 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and pancreas, and related phenotypes are behavior/neurological and cellular

Wikipedia : 74 Mesenchymal chondrosarcoma is a form of malignant chondrosarcoma. Unlike most chondrosarcomas,... more...

Related Diseases for Mesenchymal Chondrosarcoma

Diseases in the Mesenchymal Chondrosarcoma family:

Adult Mesenchymal Chondrosarcoma

Diseases related to Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 meningioma, radiation-induced 30.8 VIM SMARCB1 MUC1
2 myxoid chondrosarcoma 30.5 SYP SMARCB1 MUC1
3 osteochondroma 30.4 VIM NCOA2 HEY1
4 chondrosarcoma 30.3 VIM SPARC SOX9 PDGFRA NCOA2 MUC1
5 reticulum cell sarcoma 30.3 VIM MUC1 DES
6 extraosseous chondrosarcoma 30.3 SYP SMARCB1 ENO2
7 sarcomatoid mesothelioma 30.3 VIM MUC1 DES
8 dedifferentiated liposarcoma 30.3 MYOG MUC1 DES
9 secretory meningioma 30.3 VIM SMARCB1 MUC1 KRT7
10 hemangiopericytoma, malignant 30.3 VIM SYP MYOG MUC1 ENO2 DES
11 chondromyxoid fibroma 30.3 VIM SOX9 DES
12 fibroma 30.3 VIM KRT7 DES
13 monophasic synovial sarcoma 30.0 VIM MUC1 KRT7
14 fibrous histiocytoma 29.9 VIM MYOG ENO2 DES
15 chondrosarcoma, extraskeletal myxoid 29.9 SYP SMARCB1 MYOG ENO2
16 embryonal sarcoma 29.9 VIM MYOG MYOD1 DES
17 hemangioma 29.7 SYP MUC1 KRT7 ENO2
18 liposarcoma 29.6 VIM PDGFRA MYOG DES
19 hydrocephalus 29.5 VIM SYP SMARCB1 ENO2
20 spindle cell sarcoma 29.5 VIM NCOA2 MYOG MUC1 KRT7 DES
21 ewing sarcoma 29.4 VIM SYP PDGFRA MYOG ENO2 DES
22 sarcoma, synovial 29.2 VIM SMARCB1 MYOG MUC1 KRT7 DES
23 papilloma of choroid plexus 29.1 SYP SMARCB1 MUC1 KRT7 ENO2
24 teratoma 29.1 VIM SYP SMARCB1 KRT7 ENO2
25 pleomorphic adenoma 28.8 VIM MUC1 KRT7 HRAS DES
26 cavernous hemangioma 28.8 VIM SYP PDGFRA MUC1 KRT7 DES
27 neurilemmoma 28.7 VIM SMARCB1 PDGFRA MUC1 ENO2 DES
28 renal cell carcinoma, nonpapillary 28.1 VIM PDGFRA MUC1 KRT7 HRAS ENO2
29 rhabdomyosarcoma 27.5 VIM SYP PDGFRA NCOA2 MYOG MYOD1
30 sarcoma 27.3 VIM SMARCB1 PDGFRA MYOG MYOD1 MUC1
31 medulloblastoma 26.7 VIM SYP SOX9 SMARCB1 PDGFRA MYOG
32 adult mesenchymal chondrosarcoma 12.7
33 extraskeletal mesenchymal chondrosarcoma 12.7
34 pediatric mesenchymal chondrosarcoma 12.5
35 rare tumor 10.6
36 spinal canal intradural extramedullary neoplasm 10.5 NCOA2 HEY1
37 ischemic fasciitis 10.5 MUC1 DES
38 myocardium cancer 10.5 SYP MYOG
39 infantile digital fibromatosis 10.5 VIM DES
40 vulvar eccrine porocarcinoma 10.5 SYP MUC1
41 inflammatory leiomyosarcoma 10.5 MYOG DES
42 lymphangiomatosis 10.5 VIM DES
43 lung combined type small cell carcinoma 10.5 SYP MYOG
44 esophageal neuroendocrine tumor 10.5 SYP MUC1
45 cerebral primitive neuroectodermal tumor 10.5 SYP MUC1
46 exophthalmos 10.5
47 cervical polyp 10.5 MYOG DES
48 primary hepatic neuroendocrine carcinoma 10.5 VIM SYP
49 endometrial mucinous adenocarcinoma 10.5 VIM MUC1
50 glomangiomyoma 10.5 VIM SYP

Graphical network of the top 20 diseases related to Mesenchymal Chondrosarcoma:



Diseases related to Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Mesenchymal Chondrosarcoma

UMLS symptoms related to Mesenchymal Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Mesenchymal Chondrosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.2 DES ENO2 HRAS MYOG NCOA2 PDGFRA
2 cellular MP:0005384 10.17 CDX1 DES ENO2 HEY1 KRT7 MYOG
3 growth/size/body region MP:0005378 10.06 ENO2 HEY1 HRAS IRF2BP2 MYOD1 MYOG
4 embryo MP:0005380 10.02 CDX1 HEY1 IRF2BP2 MYOG NCOA2 PDGFRA
5 craniofacial MP:0005382 9.95 CDX1 ENO2 HEY1 HRAS PDGFRA SOX9
6 integument MP:0010771 9.86 CDX1 HRAS MYOG NCOA2 PDGFRA SMARCB1
7 muscle MP:0005369 9.76 DES HEY1 MYOD1 MYOG PDGFRA SMARCB1
8 normal MP:0002873 9.56 CDX1 HEY1 HRAS MYOD1 MYOG PDGFRA
9 respiratory system MP:0005388 9.17 ENO2 HRAS MYOD1 MYOG PDGFRA SOX9

Drugs & Therapeutics for Mesenchymal Chondrosarcoma

Drugs for Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
4
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
5
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9
Liposomal doxorubicin Phase 2, Phase 3 31703
10
Isophosphamide mustard Phase 2, Phase 3 0
11
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
12
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
14
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
15 Anti-Infective Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Antifungal Agents Phase 2
18 Immunologic Factors Phase 2
19 Antirheumatic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754) Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
2 A Phase 2, Single Arm, Multi Center Trial Evaluating the Efficacy of the COmbination of Sirolimus and cYclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and chOndrosarcoma Recruiting NCT02821507 Phase 2 sirolimus and cyclophosphamide
3 A Phase 2 Study of GDC-0449 in Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib
4 Phase II Study on Trabectedin in Advanced Rearranged Mesenchymal Chondrosarcoma Not yet recruiting NCT04305548 Phase 2 Trabectedin

Search NIH Clinical Center for Mesenchymal Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, mesenchymal

Genetic Tests for Mesenchymal Chondrosarcoma

Anatomical Context for Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Mesenchymal Chondrosarcoma:

40
Bone, Kidney, Pancreas, Lung, Brain, Spinal Cord, Heart

Publications for Mesenchymal Chondrosarcoma

Articles related to Mesenchymal Chondrosarcoma:

(show top 50) (show all 574)
# Title Authors PMID Year
1
Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases. 61 54
20123451 2010
2
[Clinicopathology analysis of mesenchymal chondrosarcoma in soft tissue]. 54 61
17068623 2006
3
Desmin and myogenin reactivity in mesenchymal chondrosarcoma: a potential diagnostic pitfall. 61 54
16405671 2006
4
Congenital mesenchymal chondrosarcoma of the orbit: case report and review of the literature. 54 61
15121382 2004
5
The impact of osteonectin for differential diagnosis of osteogenic bone tumors: an immunohistochemical and in situ hybridization approach. 54 61
8717113 1996
6
Time lapse analysis of tumor response in patients with soft tissue sarcoma treated with trabectedin: A pooled analysis of two phase II clinical trials. 61
32220056 2020
7
Primary intraocular mesenchymal chondrosarcoma: a histopathological surprise in an enucleated eye. 61
31874712 2020
8
NKX3-1 Is a Useful Immunohistochemical Marker of EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma. 61
31972596 2020
9
[Detection and analysis of HEY1-NCOA2 fusion gene in mesenchymal chondrosarcoma]. 61
32486542 2020
10
Intracranial extra-axial mesenchymal chondrosarcoma in a 16-month-old patient with a literature review of pediatric patients. 61
32382867 2020
11
Sarcoma metastasis to the pancreas: experience at a single institution. 61
32311873 2020
12
How Does the Skeletal Oncology Research Group Algorithm's Prediction of 5-year Survival in Patients with Chondrosarcoma Perform on International Validation? 61
32433107 2020
13
Metastasectomy of left atrial mesenchymal chondrosarcoma. 61
32413904 2020
14
NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker. 61
32327700 2020
15
Intracranial Mesenchymal Chondrosarcoma Lacking the Typical Histopathological Features Diagnosed by HEY1-NCOA2 Gene Fusion. 61
32322450 2020
16
Mesenchymal Chondrosarcoma of the Brain with Metastasis: A Case Report with Literature Review. 61
32367992 2020
17
Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features. 61
32257101 2020
18
[Maxillary mesenchymal chondrosarcoma: a case report]. 61
32193916 2020
19
[Cartilage tumors: morphology, genetics, and current aspects of target therapy]. 61
32060685 2020
20
Primary mesenchymal chondrosarcoma of the kidney without HEY1-NCOA2 and IRF2BP2-CDX1 fusion: A case report and review. 61
31897203 2020
21
Maxillary mesenchymal chondrosarcoma leading to a diagnosis of Li-Fraumeni syndrome. 61
31976063 2020
22
What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification. 61
31701222 2020
23
[Clinical analysis of sinonasal chondrosarcoma in 47 cases]. 61
31954383 2020
24
A challenging case of Mesenchymal Chondrosarcoma involving the thyroid and special considerations for diagnosis. 61
32180995 2020
25
Surgical treatment of metastatic mesenchymal chondrosarcoma to the spine: A case report. 61
32000368 2020
26
Ewing sarcoma and Ewing-like tumors. 61
31802230 2020
27
Robot-assisted radical nephrectomy for primary renal mesenchymal chondrosarcoma: case report and literature review. 61
30909775 2019
28
Primary intradural extramedullary spinal mesenchymal chondrosarcoma: case report and literature review. 61
31484514 2019
29
Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Case Report and Review of the Literature of Reported Cases in Adults and Children. 61
31158544 2019
30
Chondrosarcoma of the jaw: a retrospective series. 61
31204208 2019
31
Anaplastic sarcoma of the kidney: Case report and literature review. 61
31007495 2019
32
Small round cell lesions of the bone: Diagnostic approach, differential diagnoses and impact on treatment. 61
30971540 2019
33
Mesenchymal chondrosarcoma of maxilla in paediatric patient. 61
30852518 2019
34
The Differences Between Intracranial Mesenchymal Chondrosarcoma and Conventional Chondrosarcoma in Clinical Features and Outcomes. 61
30415056 2019
35
Vertebral body chondrosarcoma with metastasis to the scalp. 61
31131120 2019
36
An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing. 61
30582658 2019
37
Primary paediatric epidural sarcomas: molecular exploration of three cases. 61
30819134 2019
38
Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma. 61
30082492 2019
39
Metastasis from Intracranial Mesenchymal Chondrosarcoma: Report of a Rare Case. 61
29972855 2019
40
Mesenchymal chondrosarcoma metastasising to the pancreas. 61
30598468 2018
41
Extraskeletal Mesenchymal Chondrosarcoma. 61
30407856 2018
42
Minute mesenchymal chondrosarcoma within osteochondroma: an unexpected diagnosis confirmed by HEY1-NCOA2 fusion. 61
29596896 2018
43
Novel MEIS1-NCOA2 Gene Fusions Define a Distinct Primitive Spindle Cell Sarcoma of the Kidney. 61
30179902 2018
44
Multiple Surgical Treatments for Repeated Recurrence of Skull Base Mesenchymal Chondrosarcoma. 61
30327751 2018
45
Mesenchymal chondrosarcoma of the orbit: imaging features of CT and MRI. 61
29975155 2018
46
Primary orbital mesenchymal chondrosarcoma. 61
30340745 2018
47
Mesenchymal chondrosarcoma of the parapharyngeal space. 61
30488876 2018
48
Mesenchymal Chondrosarcoma of the Orbit Attached to the Optic Nerve. 61
29863559 2018
49
Ewing Sarcoma and the History of Similar and Possibly Related Small Round Cell Tumors: From Whence Have We Come and Where are We Going? 61
29911999 2018
50
Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. 61
29572501 2018

Variations for Mesenchymal Chondrosarcoma

Expression for Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Mesenchymal Chondrosarcoma.

Pathways for Mesenchymal Chondrosarcoma

Pathways related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.05 VIM MUC1 KRT7 DES
2
Show member pathways
11.53 VIM KRT7 DES
3 11.23 NCOA2 MYOG CDX1
4 11.15 VIM SYP SOX9 PDGFRA
5 11 SPARC SOX9 MYOG MYOD1 DES

GO Terms for Mesenchymal Chondrosarcoma

Cellular components related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.83 VIM SPARC SOX9 SMARCB1 PDGFRA NCOA2
2 nuclear chromatin GO:0000790 9.23 SOX9 SMARCB1 NCOA2 MYOG MYOD1 MUC1

Biological processes related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.88 SOX9 SMARCB1 MYOG MYOD1 HEY1 CDX1
2 ossification GO:0001503 9.65 SPARC SOX9 MYOG
3 myotube differentiation GO:0014902 9.46 MYOG MYOD1
4 positive regulation of phospholipase C activity GO:0010863 9.43 PDGFRA HRAS
5 negative regulation of biomineral tissue development GO:0070168 9.37 SOX9 HEY1
6 positive regulation of skeletal muscle fiber development GO:0048743 9.32 MYOG MYOD1
7 response to gravity GO:0009629 9.26 SPARC MYOG
8 positive regulation of transcription by RNA polymerase II GO:0045944 9.23 SOX9 SMARCB1 NCOA2 MYOG MYOD1 HRAS
9 muscle cell fate commitment GO:0042693 9.16 MYOG MYOD1
10 positive regulation of histone H4 acetylation GO:0090240 8.96 SMARCB1 MUC1

Molecular functions related to Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.63 SOX9 NCOA2 MYOG MYOD1 HEY1 CDX1
2 proximal promoter sequence-specific DNA binding GO:0000987 9.43 SOX9 MYOG MYOD1
3 protein dimerization activity GO:0046983 9.26 NCOA2 MYOG MYOD1 HEY1
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.17 SOX9 SMARCB1 NCOA2 MYOG MYOD1 MUC1

Sources for Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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