MCID: MSN006
MIFTS: 34

Mesenchymoma

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Mesenchymoma

MalaCards integrated aliases for Mesenchymoma:

Name: Mesenchymoma 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2668
MeSH 44 D008637
NCIt 50 C3233
SNOMED-CT 68 44524009
UMLS 73 C0025464

Summaries for Mesenchymoma

MalaCards based summary : Mesenchymoma is related to benign mesenchymoma and malignant mesenchymoma. An important gene associated with Mesenchymoma is MB (Myoglobin), and among its related pathways/superpathways is Regulation of retinoblastoma protein. The drugs Vincristine and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotype is muscle.

Related Diseases for Mesenchymoma

Diseases in the Mesenchymoma family:

Benign Mesenchymoma Malignant Mesenchymoma
Adult Malignant Mesenchymoma

Diseases related to Mesenchymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 benign mesenchymoma 33.6 ECM1 HMGA2
2 malignant mesenchymoma 32.9 DES MB MDM2 MYOD1
3 leiomyoma 30.0 DES HMGA2
4 liposarcoma 29.8 DES HMGA2 MB MDM2
5 leiomyosarcoma 29.8 DES MB MDM2
6 pleomorphic liposarcoma 29.7 DES MDM2
7 pleomorphic adenoma 29.6 HMGA2 MDM2
8 rhabdomyosarcoma 29.5 DES MB MDM2 MYOD1
9 histiocytoma 29.5 MB MDM2 MYOD1
10 malignant fibroxanthoma 29.4 DES MDM2 MYOD1
11 childhood malignant mesenchymoma 12.1
12 adult malignant mesenchymoma 12.1
13 sarcoma 10.3
14 giant cell myocarditis 10.1 DES MB
15 angiomyoma 10.1 HMGA2 MB
16 myofibroma 10.1 DES MB
17 bilateral retinoblastoma 10.1 DES MB
18 malignant ectomesenchymoma 10.1 DES HMGA2
19 ectomesenchymoma 10.1 DES HMGA2
20 thymus lipoma 10.1 HMGA2 MB
21 immune system organ benign neoplasm 10.1 HMGA2 MB
22 breast rhabdomyosarcoma 10.1 MB MYOD1
23 adenosarcoma 10.1 DES MB
24 pleomorphic rhabdomyosarcoma 10.1 MB MYOD1
25 adult fibrosarcoma 10.0 MB MYOD1
26 rhabdoid cancer 10.0 MB MYOD1
27 conventional leiomyosarcoma 10.0 HMGA2 MYOD1
28 infantile myofibromatosis 10.0 DES MB
29 gas gangrene 10.0 MB MYOD1
30 smooth muscle tumor 10.0 DES HMGA2
31 breast cancer 10.0
32 fibrosarcoma 10.0
33 gallbladder sarcoma 10.0 DES MYOD1
34 inflammatory leiomyosarcoma 10.0 DES MYOD1
35 horner's syndrome 10.0 DES MYOD1
36 skeletal muscle cancer 10.0 MB MYOD1
37 sclerosing liposarcoma 10.0 MB MDM2
38 pleomorphic lipoma 10.0 HMGA2 MDM2
39 mixed liposarcoma 10.0 MB MDM2
40 muscle tissue disease 10.0 MB MYOD1
41 endometrial stromal sarcoma 10.0 DES MB
42 atypical lipomatous tumor 10.0 HMGA2 MDM2
43 rhabdoid tumor predisposition syndrome 1 10.0 DES MYOD1
44 spindle cell lipoma 9.9 DES MDM2
45 well-differentiated liposarcoma 9.9 HMGA2 MDM2
46 myxosarcoma 9.9 MB MDM2
47 infiltrating lipoma 9.9 HMGA2 MDM2
48 ischemic fasciitis 9.9 DES MDM2
49 spindle cell sarcoma 9.9 DES MDM2
50 undifferentiated embryonal sarcoma of the liver 9.9 MDM2 MYOD1

Graphical network of the top 20 diseases related to Mesenchymoma:



Diseases related to Mesenchymoma

Symptoms & Phenotypes for Mesenchymoma

MGI Mouse Phenotypes related to Mesenchymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 DES MB MDM2 MYOD1

Drugs & Therapeutics for Mesenchymoma

Drugs for Mesenchymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2 57-22-7, 2068-78-2 5978
2
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
3
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
4
Mechlorethamine Approved, Investigational Phase 3,Phase 1 51-75-2 4033
5
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
6
Mesna Approved, Investigational Phase 3 3375-50-6 598
7
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
8
Irinotecan Approved, Investigational Phase 3,Phase 2 100286-90-6, 97682-44-5 60838
9
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
10
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
11
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
12
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 38904 498142
13
Vinorelbine Approved, Investigational Phase 3 71486-22-1 60780 44424639
14
Morphine Approved, Investigational Phase 3 57-27-2 5288826
15
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
16
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
17
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
18
Camptothecin Experimental Phase 3,Phase 2 7689-03-4
19
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
20 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
21 Immunosuppressive Agents Phase 3,Phase 2
22 topoisomerase I inhibitors Phase 3,Phase 2
23 Etoposide phosphate Phase 3,Phase 2
24 Alkylating Agents Phase 3,Phase 2,Phase 1
25 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
27 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
28 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
29 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
30 Antirheumatic Agents Phase 3,Phase 2
31 Anti-Infective Agents Phase 3,Phase 2
32 Adjuvants, Immunologic Phase 3,Phase 1
33 Antimitotic Agents Phase 3,Phase 2
34 Immunologic Factors Phase 3,Phase 2,Phase 1
35
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
36
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
37
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
38
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
39
Gemcitabine Approved Phase 2 95058-81-4 60750
40 Protein Kinase Inhibitors Phase 2,Phase 1
41 Imatinib Mesylate Phase 2,Phase 1 220127-57-1 123596
42 Angiogenesis Modulating Agents Phase 2,Phase 1
43 Angiogenesis Inhibitors Phase 2,Phase 1
44 Antimetabolites Phase 2
45 Antiviral Agents Phase 2
46 Antimetabolites, Antineoplastic Phase 2
47 Protective Agents Phase 2
48 razoxane Phase 2
49 Cardiotonic Agents Phase 2
50 Antibodies, Monoclonal Phase 1

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Unknown status NCT00354744 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate
2 Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma Unknown status NCT00379457 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate;vinorelbine tartrate
3 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Unknown status NCT01344018 Phase 3
4 Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma Completed NCT00003958 Phase 3 vincristine sulfate;cyclophosphamide;topotecan hydrochloride
5 Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00354835 Phase 3 Irinotecan Hydrochloride;Cyclophosphamide;Vincristine Sulfate
6 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
8 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
9 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
10 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
11 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
12 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
13 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
14 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
15 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
16 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
17 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma Completed NCT00003955 Phase 2 cyclophosphamide;irinotecan hydrochloride;vincristine sulfate
18 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
19 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
20 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
21 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
22 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
23 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
24 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
25 Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma Active, not recruiting NCT00077285 Phase 2 carboplatin;cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate
26 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
27 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
28 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
29 NHS-IL12 for Solid Tumors Recruiting NCT01417546 Phase 1 NHS-IL-12
30 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
31 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
32 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Mesenchymoma

Cochrane evidence based reviews: mesenchymoma

Genetic Tests for Mesenchymoma

Anatomical Context for Mesenchymoma

MalaCards organs/tissues related to Mesenchymoma:

41
Bone, Lung, Liver, Heart, Kidney, Smooth Muscle, Thymus

Publications for Mesenchymoma

Articles related to Mesenchymoma:

(show top 50) (show all 256)
# Title Authors Year
1
Benign mesenchymoma of bone: A rare case report. ( 29893345 )
2018
2
Primary malignant mesenchymoma of bladder: Case report and review of the literature. ( 28796040 )
2017
3
Fibrocartilaginous mesenchymoma of bone: a single-institution experience with molecular investigations and a review of the literature. ( 28239886 )
2017
4
Critical reappraisal of primary osseous composite sarcoma (malignant mesenchymoma) - analysis of four cases and literature review. ( 27102568 )
2016
5
Rare Head and Neck Benign Mesenchymoma in Close Proximity to Submandibular Gland in a Pediatric Patient: Case Report and Review of the Literature. ( 26064744 )
2015
6
Malignant mesenchymoma with widespread metastasis including bone marrow involvement in a dog. ( 25132008 )
2014
7
Multidetector CT and histological features of benign mesenchymoma of the infratemporal space: a rare case report. ( 22282510 )
2013
8
Fibrocartilaginous mesenchymoma arising in the pubic bone: a case report. ( 23692424 )
2013
9
Diagnosis and treatment considerations in a case of malignant mesenchymoma in an African fur seal (Arctocephalus pusillus). ( 23805568 )
2013
10
Metastatic leiomyosarcoma of the uterus with heterologous differentiation to malignant mesenchymoma. ( 22833086 )
2012
11
Congenital benign mesenchymoma on the palm. ( 22381468 )
2012
12
Malignant mesenchymoma of the heart base in a dog with infiltration of the pericardium and metastasis to the lung. ( 22516086 )
2012
13
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. ( 23082265 )
2012
14
Soft-tissue benign mesenchymoma in a pediatric patient. ( 23431526 )
2012
15
Congenital mesenchymoma of tibia: case report and review of literature. ( 23217910 )
2012
16
Benign mesenchymoma presenting as a paraspinal mass. ( 22535235 )
2012
17
Malignant mesenchymoma in the nasal cavity of a bull. ( 21306728 )
2011
18
Fibrocartilaginous mesenchymoma, a unique osseous lesion: case report with review of the literature. ( 21560005 )
2011
19
Fibrocartilaginous mesenchymoma of the spine in a child: a case report. ( 20183926 )
2010
20
An intra-abdominal malignant mesenchymoma associated with nonabsorbable sutures in a ferret (Mustela putorius furo). ( 20224105 )
2010
21
Malignant mesenchymoma surrounding the esophageal hiatus. ( 20103193 )
2010
22
Malignant mesenchymoma of the thyroid: case report and literature review. ( 20572598 )
2010
23
Surgical case of giant malignant mesenchymoma in the posterior mediastinum that recurred in the bilateral mediastinum. ( 18781043 )
2008
24
Uterine malignant mesenchymoma, arising in a leiomyoma, with pulmonary metastases. ( 17257144 )
2007
25
Left atrial malignant mesenchymoma--emergency resection and mitral replacement. ( 17664193 )
2007
26
Secondary localisation of an intra-thoracic benign mesenchymoma in the fossa poplitea: a rare paediatric case. ( 16544227 )
2006
27
Benign mesenchymoma of the mediastinum: a report and review of the literature. ( 21289950 )
2006
28
Huge benign mesenchymoma in pharynx-esophagus. ( 16731171 )
2006
29
Intermandibular malignant mesenchymoma in a crossbreed dog. ( 16961475 )
2006
30
Fibrocartilagenous mesenchymoma of bone: the youngest reported case in a patient aged 1 year and 7 months. ( 15976352 )
2005
31
Primary osteochondrorhabdomyosarcoma (malignant mesenchymoma) of the fibula: a rare tumour in an unusual site -- case report and review of the literature. ( 15601312 )
2004
32
Malignant mesenchymoma arising from a uterine leiomyoma in the menopause. ( 15581987 )
2004
33
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone. ( 15792374 )
2004
34
Mesenchymoma: an unusual tumour of the lip. ( 15225956 )
2004
35
Benign renal mesenchymoma in the pediatric age group: a novel pathologic and karyotype entity. ( 15134997 )
2004
36
Malignant mesenchymoma of the orbit: case report and review of the literature. ( 12578773 )
2003
37
Prognostic factors in the so-called malignant mesenchymoma: a clinicopathological and immunohistochemical analysis. ( 12792727 )
2003
38
Intraoral benign mesenchymoma: a report of 10 cases and review of the literature. ( 12539029 )
2003
39
Malignant mesenchymoma of the pleura. ( 17670075 )
2003
40
Resection of a large benign pharyngo-oesophageal submucous mesenchymoma via laterocervical approach. ( 12648382 )
2003
41
Unusual renal mesenchymoma with unknown malignant potential in an infant. ( 12518350 )
2003
42
Fibrocartilaginous mesenchymoma arising in the femur. ( 12009108 )
2002
43
Benign mesenchymoma of the tongue. ( 12402020 )
2002
44
Retroperitoneal malignant mesenchymoma: a case of mesenchymal mixed tumor with osteosarcoma, leiomyosarcoma, liposarcoma and fibrosarcoma. ( 12514345 )
2002
45
Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). ( 12021922 )
2002
46
Malignant mesenchymoma of the uterus, arising in a leiomyoma. ( 11903599 )
2002
47
Radical resection of a malignant mesenchymoma with hypogastric artery transposition. ( 12210036 )
2002
48
Primary malignant mesenchymoma of the heart. ( 11788281 )
2002
49
Malignant mesenchymoma of the lower leg. ( 11684725 )
2001
50
Giant benign mesenchymoma of the mediastinum with unusual magnetic resonance imaging findings. ( 11716049 )
2001

Variations for Mesenchymoma

Expression for Mesenchymoma

Search GEO for disease gene expression data for Mesenchymoma.

Pathways for Mesenchymoma

Pathways related to Mesenchymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.37 MDM2 MYOD1

GO Terms for Mesenchymoma

Molecular functions related to Mesenchymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.8 ECM1 MDM2 MYOD1

Sources for Mesenchymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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