MCID: MSN006
MIFTS: 36

Mesenchymoma

Categories: Cancer diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Mesenchymoma

MalaCards integrated aliases for Mesenchymoma:

Name: Mesenchymoma 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2668
MeSH 44 D008637
NCIt 50 C3233
SNOMED-CT 68 189809007 44524009
UMLS 73 C0025464

Summaries for Mesenchymoma

MalaCards based summary : Mesenchymoma is related to malignant mesenchymoma and pleomorphic liposarcoma. An important gene associated with Mesenchymoma is MB (Myoglobin), and among its related pathways/superpathways is Regulation of retinoblastoma protein. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotype is muscle.

Related Diseases for Mesenchymoma

Diseases in the Mesenchymoma family:

Benign Mesenchymoma Malignant Mesenchymoma
Adult Malignant Mesenchymoma

Diseases related to Mesenchymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 malignant mesenchymoma 31.8 DES MB MDM2 MYOD1
2 pleomorphic liposarcoma 29.8 DES MDM2
3 pleomorphic adenoma 29.5 HMGA2 MDM2
4 leiomyoma 29.4 DES HMGA2
5 leiomyosarcoma 29.4 DES MB MDM2
6 liposarcoma 28.9 DES HMGA2 MB MDM2
7 rhabdomyosarcoma 28.5 DES MB MDM2 MYOD1
8 benign mesenchymoma 12.2
9 childhood malignant mesenchymoma 11.9
10 adult malignant mesenchymoma 11.9
11 angiomyoma 10.4 HMGA2 MB
12 giant cell myocarditis 10.4 DES MB
13 malignant triton tumor 10.4 DES MB
14 sclerosing liposarcoma 10.3 MB MDM2
15 myofibroma 10.3 DES MB
16 bilateral retinoblastoma 10.3 DES MB
17 immune system organ benign neoplasm 10.3 HMGA2 MB
18 thymus lipoma 10.3 HMGA2 MB
19 mixed liposarcoma 10.3 MB MDM2
20 malignant ectomesenchymoma 10.3 DES HMGA2
21 ectomesenchymoma 10.3 DES HMGA2
22 adenosarcoma 10.3 DES MB
23 atypical lipomatous tumor 10.2 HMGA2 MDM2
24 myxosarcoma 10.2 MB MDM2
25 well-differentiated liposarcoma 10.2 HMGA2 MDM2
26 spindle cell lipoma 10.2 DES MDM2
27 pleomorphic rhabdomyosarcoma 10.2 MB MYOD1
28 infiltrating lipoma 10.2 HMGA2 MDM2
29 adult fibrosarcoma 10.2 MB MYOD1
30 infantile myofibromatosis 10.2 DES MB
31 ischemic fasciitis 10.2 DES MDM2
32 pleomorphic lipoma 10.2 HMGA2 MDM2
33 glomangioma 10.2 DES MB
34 conventional leiomyosarcoma 10.1 HMGA2 MYOD1
35 smooth muscle tumor 10.1 DES HMGA2
36 spindle cell sarcoma 10.1 DES MDM2
37 cervical polyp 10.1 DES MYOD1
38 gallbladder sarcoma 10.1 DES MYOD1
39 sarcoma 10.1
40 undifferentiated embryonal sarcoma of the liver 10.1 MDM2 MYOD1
41 atypical teratoid rhabdoid tumor 10.1 DES HMGA2
42 inflammatory leiomyosarcoma 10.1 DES MYOD1
43 horner's syndrome 10.1 DES MYOD1
44 hemangiopericytoma, malignant 10.0 DES MDM2
45 myxoid liposarcoma 10.0 HMGA2 MDM2
46 spindle cell liposarcoma 10.0 MDM2 MYOD1
47 hepatitis 10.0
48 skeletal muscle cancer 10.0 MB MYOD1
49 muscle tissue disease 10.0 MB MYOD1
50 rhabdoid cancer 10.0 DES MYOD1

Graphical network of the top 20 diseases related to Mesenchymoma:



Diseases related to Mesenchymoma

Symptoms & Phenotypes for Mesenchymoma

MGI Mouse Phenotypes related to Mesenchymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 MDM2 MYOD1 DES MB

Drugs & Therapeutics for Mesenchymoma

Drugs for Mesenchymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
3
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
4
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
5
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
6
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
7
Morphine Approved, Investigational Phase 3 57-27-2 5288826
8
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
9
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
10
Vinorelbine Approved, Investigational Phase 3 71486-22-1 60780 44424639
11
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
12
Irinotecan Approved, Investigational Phase 3,Phase 2 97682-44-5, 100286-90-6 60838
13
Mechlorethamine Approved, Investigational Phase 3,Phase 1 51-75-2 4033
14
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
15
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
16
Mesna Approved, Investigational Phase 3 3375-50-6 598
17
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
18
Camptothecin Experimental Phase 3,Phase 2 7689-03-4
19 Alkylating Agents Phase 3,Phase 2,Phase 1
20 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
21 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
22 Anti-Infective Agents Phase 3,Phase 2
23 Antimitotic Agents Phase 3,Phase 2
24 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
26 Antirheumatic Agents Phase 3,Phase 2
27 Etoposide phosphate Phase 3,Phase 2
28 Immunosuppressive Agents Phase 3,Phase 2
29
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
30 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
31 topoisomerase I inhibitors Phase 3,Phase 2
32 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
33 Adjuvants, Immunologic Phase 3,Phase 1
34
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
35
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
36
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
37
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
38
Gemcitabine Approved Phase 2 95058-81-4 60750
39 Imatinib Mesylate Phase 2,Phase 1 220127-57-1 123596
40 Protein Kinase Inhibitors Phase 2,Phase 1
41 Angiogenesis Inhibitors Phase 2,Phase 1
42 Angiogenesis Modulating Agents Phase 2,Phase 1
43 Antimetabolites Phase 2
44 Antimetabolites, Antineoplastic Phase 2
45 Antiviral Agents Phase 2
46 Protective Agents Phase 2
47 razoxane Phase 2
48 Antibodies Phase 1
49 Antibodies, Monoclonal Phase 1
50 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma Unknown status NCT00379457 Phase 3 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate;vinorelbine tartrate
2 Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma Completed NCT00003958 Phase 3 vincristine sulfate;cyclophosphamide;topotecan hydrochloride
3 Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00354835 Phase 3 Irinotecan Hydrochloride;Cyclophosphamide;Vincristine Sulfate
4 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00002995 Phase 3 cyclophosphamide;vincristine sulfate
6 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
8 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
9 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Recruiting NCT01344018 Phase 3
10 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Active, not recruiting NCT00354744 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate
11 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
12 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
13 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
14 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
15 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
16 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
17 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma Completed NCT00003955 Phase 2 cyclophosphamide;irinotecan hydrochloride;vincristine sulfate
18 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
19 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
20 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
21 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
22 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
23 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
24 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
25 Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma Active, not recruiting NCT00077285 Phase 2 carboplatin;cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate
26 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
27 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
28 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1 ifosfamide;pegylated liposomal doxorubicin hydrochloride
29 NHS-IL12 for Solid Tumors Recruiting NCT01417546 Phase 1 NHS-IL-12
30 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
31 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
32 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Mesenchymoma

Cochrane evidence based reviews: mesenchymoma

Genetic Tests for Mesenchymoma

Anatomical Context for Mesenchymoma

MalaCards organs/tissues related to Mesenchymoma:

41
Bone, Lung, Liver, Heart, Kidney, Tongue, Uterus

Publications for Mesenchymoma

Articles related to Mesenchymoma:

(show top 50) (show all 252)
# Title Authors Year
1
Benign mesenchymoma of bone: A rare case report. ( 29893345 )
2018
2
Primary malignant mesenchymoma of bladder: Case report and review of the literature. ( 28796040 )
2017
3
Fibrocartilaginous mesenchymoma of bone: a single-institution experience with molecular investigations and a review of the literature. ( 28239886 )
2017
4
Critical reappraisal of primary osseous composite sarcoma (malignant mesenchymoma) - analysis of four cases and literature review. ( 27102568 )
2016
5
Rare Head and Neck Benign Mesenchymoma in Close Proximity to Submandibular Gland in a Pediatric Patient: Case Report and Review of the Literature. ( 26064744 )
2015
6
Malignant mesenchymoma with widespread metastasis including bone marrow involvement in a dog. ( 25132008 )
2014
7
Multidetector CT and histological features of benign mesenchymoma of the infratemporal space: a rare case report. ( 22282510 )
2013
8
Fibrocartilaginous mesenchymoma arising in the pubic bone: a case report. ( 23692424 )
2013
9
Diagnosis and treatment considerations in a case of malignant mesenchymoma in an African fur seal (Arctocephalus pusillus). ( 23805568 )
2013
10
Metastatic leiomyosarcoma of the uterus with heterologous differentiation to malignant mesenchymoma. ( 22833086 )
2012
11
Congenital benign mesenchymoma on the palm. ( 22381468 )
2012
12
Malignant mesenchymoma of the heart base in a dog with infiltration of the pericardium and metastasis to the lung. ( 22516086 )
2012
13
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. ( 23082265 )
2012
14
Soft-tissue benign mesenchymoma in a pediatric patient. ( 23431526 )
2012
15
Congenital mesenchymoma of tibia: case report and review of literature. ( 23217910 )
2012
16
Benign mesenchymoma presenting as a paraspinal mass. ( 22535235 )
2012
17
Malignant mesenchymoma in the nasal cavity of a bull. ( 21306728 )
2011
18
Fibrocartilaginous mesenchymoma, a unique osseous lesion: case report with review of the literature. ( 21560005 )
2011
19
Fibrocartilaginous mesenchymoma of the spine in a child: a case report. ( 20183926 )
2010
20
An intra-abdominal malignant mesenchymoma associated with nonabsorbable sutures in a ferret (Mustela putorius furo). ( 20224105 )
2010
21
Malignant mesenchymoma surrounding the esophageal hiatus. ( 20103193 )
2010
22
Malignant mesenchymoma of the thyroid: case report and literature review. ( 20572598 )
2010
23
Surgical case of giant malignant mesenchymoma in the posterior mediastinum that recurred in the bilateral mediastinum. ( 18781043 )
2008
24
Uterine malignant mesenchymoma, arising in a leiomyoma, with pulmonary metastases. ( 17257144 )
2007
25
Left atrial malignant mesenchymoma--emergency resection and mitral replacement. ( 17664193 )
2007
26
Secondary localisation of an intra-thoracic benign mesenchymoma in the fossa poplitea: a rare paediatric case. ( 16544227 )
2006
27
Benign mesenchymoma of the mediastinum: a report and review of the literature. ( 21289950 )
2006
28
Huge benign mesenchymoma in pharynx-esophagus. ( 16731171 )
2006
29
Intermandibular malignant mesenchymoma in a crossbreed dog. ( 16961475 )
2006
30
Fibrocartilagenous mesenchymoma of bone: the youngest reported case in a patient aged 1 year and 7 months. ( 15976352 )
2005
31
Primary osteochondrorhabdomyosarcoma (malignant mesenchymoma) of the fibula: a rare tumour in an unusual site -- case report and review of the literature. ( 15601312 )
2004
32
Malignant mesenchymoma arising from a uterine leiomyoma in the menopause. ( 15581987 )
2004
33
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone. ( 15792374 )
2004
34
Mesenchymoma: an unusual tumour of the lip. ( 15225956 )
2004
35
Benign renal mesenchymoma in the pediatric age group: a novel pathologic and karyotype entity. ( 15134997 )
2004
36
Malignant mesenchymoma of the orbit: case report and review of the literature. ( 12578773 )
2003
37
Prognostic factors in the so-called malignant mesenchymoma: a clinicopathological and immunohistochemical analysis. ( 12792727 )
2003
38
Intraoral benign mesenchymoma: a report of 10 cases and review of the literature. ( 12539029 )
2003
39
Malignant mesenchymoma of the pleura. ( 17670075 )
2003
40
Resection of a large benign pharyngo-oesophageal submucous mesenchymoma via laterocervical approach. ( 12648382 )
2003
41
Unusual renal mesenchymoma with unknown malignant potential in an infant. ( 12518350 )
2003
42
Fibrocartilaginous mesenchymoma arising in the femur. ( 12009108 )
2002
43
Benign mesenchymoma of the tongue. ( 12402020 )
2002
44
Retroperitoneal malignant mesenchymoma: a case of mesenchymal mixed tumor with osteosarcoma, leiomyosarcoma, liposarcoma and fibrosarcoma. ( 12514345 )
2002
45
Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). ( 12021922 )
2002
46
Malignant mesenchymoma of the uterus, arising in a leiomyoma. ( 11903599 )
2002
47
Radical resection of a malignant mesenchymoma with hypogastric artery transposition. ( 12210036 )
2002
48
Primary malignant mesenchymoma of the heart. ( 11788281 )
2002
49
Malignant mesenchymoma of the lower leg. ( 11684725 )
2001
50
Giant benign mesenchymoma of the mediastinum with unusual magnetic resonance imaging findings. ( 11716049 )
2001

Variations for Mesenchymoma

Expression for Mesenchymoma

Search GEO for disease gene expression data for Mesenchymoma.

Pathways for Mesenchymoma

Pathways related to Mesenchymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.37 MDM2 MYOD1

GO Terms for Mesenchymoma

Molecular functions related to Mesenchymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 core promoter binding GO:0001047 8.96 HMGA2 MYOD1
2 enzyme binding GO:0019899 8.8 HMGA2 MDM2 MYOD1

Sources for Mesenchymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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