MCID: MSN002
MIFTS: 41

Mesenteric Lymphadenitis

Categories: Immune diseases

Aliases & Classifications for Mesenteric Lymphadenitis

MalaCards integrated aliases for Mesenteric Lymphadenitis:

Name: Mesenteric Lymphadenitis 12 44 15 73
Mesenteric Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10782
ICD10 33 I88.0
ICD9CM 35 289.2
MeSH 44 D008640
NCIt 50 C26830
SNOMED-CT 68 44897000
UMLS 73 C0025469

Summaries for Mesenteric Lymphadenitis

MalaCards based summary : Mesenteric Lymphadenitis, also known as mesenteric adenitis, is related to appendicitis and ileitis. An important gene associated with Mesenteric Lymphadenitis is RIPK4 (Receptor Interacting Serine/Threonine Kinase 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include lymph node, appendix and lung, and related phenotypes are digestive/alimentary and growth/size/body region

Wikipedia : 76 Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number,... more...

Related Diseases for Mesenteric Lymphadenitis

Diseases related to Mesenteric Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 appendicitis 30.8 CRP IL6 LBP
2 ileitis 30.2 IL6 NOD2 TLR2
3 ulcerative colitis 29.9 CRP IL6 NOD2
4 peritonitis 29.8 CRP IL6 LBP TLR2
5 lymphadenitis 10.8
6 intussusception 10.3
7 inflammatory bowel disease 20 10.3 MRAP NOD2
8 discitis 10.3 CRP MRAP
9 aortitis 10.2 CRP MRAP
10 pyuria 10.2 CRP MRAP
11 cold agglutinin disease 10.2 CRP IL6
12 salpingitis 10.2 CRP HSPD1
13 tenosynovitis 10.2 CRP MRAP
14 cryopyrin-associated periodic syndrome 10.2 CRP IL6
15 juvenile ankylosing spondylitis 10.2 IL6 MRAP
16 acute cholangitis 10.2 CRP IL6
17 intestinal perforation 10.2 CRP NOD2
18 whipple disease 10.2 HSPD1 MRAP
19 spondyloarthropathy 1 10.2 CRP MRAP NOD2
20 palindromic rheumatism 10.2 CRP ERBB3 MRAP
21 fox-fordyce disease 10.2 CD68 MRAP
22 uremic pruritus 10.2 CRP IL6
23 chronic meningitis 10.2 CRP IL5
24 periodontitis, chronic 10.1 IL6 TLR2
25 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL5 IL6
26 bursitis 10.1 CRP MRAP
27 bone inflammation disease 10.1 CRP IL6 MRAP
28 bagassosis 10.1 IL5 IL6
29 pericoronitis 10.1 CD68 CRP
30 pelvic inflammatory disease 10.1 CRP HSPD1 TLR2
31 uveal disease 10.1 IL6 MRAP NOD2
32 neutrophilia, hereditary 10.1 CRP IL6
33 spondylitis 10.1 CRP IL6 NOD2
34 intestinal disease 10.1 CRP IL6 NOD2
35 lethal congenital contracture syndrome 2 10.1 EGF ERBB3
36 leprosy 3 10.1 HSPD1 NOD2 TLR2
37 mycoplasma pneumoniae pneumonia 10.1 CRP IL6 TLR2
38 histoplasmosis 10.1
39 gastrointestinal system disease 10.1 CRP IL6 NOD2
40 leptospirosis 10.1 CRP IL6 TLR2
41 arteriosclerosis 10.1 CRP HSPD1 IL6
42 bacterial meningitis 10.1 CRP IL6 TLR2
43 meningitis 10.1 CRP IL6 TLR2
44 multicentric castleman disease 10.1 CRP IL5 IL6
45 castleman disease 10.1 CRP IL5 IL6
46 periodontitis 10.1 CRP IL6 TLR2
47 q fever 10.1 IL6 NOD2 TLR2
48 psoriatic arthritis 10.1 CRP IL6 NOD2
49 gastroenteritis 10.1 CRP IL5 IL6
50 bronchiolitis 10.1 CRP IL5 IL6

Graphical network of the top 20 diseases related to Mesenteric Lymphadenitis:



Diseases related to Mesenteric Lymphadenitis

Symptoms & Phenotypes for Mesenteric Lymphadenitis

MGI Mouse Phenotypes related to Mesenteric Lymphadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 EGF ERBB3 IL5 IL6 MYD88 NOD2
2 growth/size/body region MP:0005378 9.7 AKR1B1 EGF ERBB3 HSPD1 IL5 IL6
3 immune system MP:0005387 9.36 CD68 CRP EGF ERBB3 IL5 IL6

Drugs & Therapeutics for Mesenteric Lymphadenitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814

Search NIH Clinical Center for Mesenteric Lymphadenitis

Cochrane evidence based reviews: mesenteric lymphadenitis

Genetic Tests for Mesenteric Lymphadenitis

Anatomical Context for Mesenteric Lymphadenitis

MalaCards organs/tissues related to Mesenteric Lymphadenitis:

41
Lymph Node, Appendix, Lung, Bone, Heart, Pancreas, Thyroid

Publications for Mesenteric Lymphadenitis

Articles related to Mesenteric Lymphadenitis:

(show top 50) (show all 149)
# Title Authors Year
1
Mesenteric lymphadenitis as a presenting feature of Whipple's disease: Value of PCR analysis. ( 30096359 )
2018
2
Mesenteric lymphadenitis as a presenting feature of Whipple's disease. ( 28660130 )
2017
3
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery". ( 28261620 )
2017
4
Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. ( 27987102 )
2017
5
Course of acute nonspecific mesenteric lymphadenitis: single-center experience. ( 28913615 )
2017
6
Role of serum cytokines in acute appendicitis and acute mesenteric lymphadenitis among children. ( 27793542 )
2016
7
Is mesenteric lymphadenitis a cause of ovarian reserve reduction? - Case Report. ( 27203306 )
2016
8
A rare case of typhoid presenting with fever, ascites, hyponatremia, thrombocytopenia, mesenteric lymphadenitis, and multi-drug resistance. ( 26015752 )
2015
9
Mesenteric lymphadenitis caused by Yersinia enterocolitica. ( 26557944 )
2015
10
Two cases of abdominal pain in children with mesenteric lymphadenitis due to Yersinia pseudotuberculosis infection. ( 24793203 )
2014
11
Cryptococcal mesenteric lymphadenitis in an immunocompromised host. ( 22529459 )
2012
12
Clinical differentiation between acute appendicitis and acute mesenteric lymphadenitis in children. ( 21157689 )
2011
13
Acute mesenteric adenitis mimicking appendicitis in an HIV patient. ( 21467718 )
2011
14
Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark. ( 19273506 )
2009
15
Fatal mesenteric lymphadenitis in cattle caused by Listeria monocytogenes. ( 19122218 )
2009
16
Nalidixic acid-resistant Salmonella enterica serotype typhi infection presenting with sub-intestinal obstruction and mesenteric adenitis. ( 18176688 )
2008
17
A case of mesenteric lymphadenitis with long-acting symptom, showing marked response to corticosteroid. ( 17827909 )
2007
18
Clinical challenges and images in GI. Yersinia enterocolitica mesenteric adenitis and terminal ileitis. ( 17128504 )
2006
19
Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum. ( 16804986 )
2006
20
Tuberculous mesenteric lymphadenitis involving the gastric wall: case report. ( 16246704 )
2005
21
A palpable right lower abdominal mass due to Yersinia mesenteric lymphadenitis. ( 14770325 )
2004
22
Cryptococcal mesenteric lymphadenitis: an unusual cause of acute abdomen. ( 15316724 )
2004
23
Mesenteric adenitis caused by Salmonella enterica serovar Enteritidis. ( 15278192 )
2004
24
Infective mesenteric adenitis masquerading as relapsed non-Hodgkin's lymphoma. ( 15621771 )
2004
25
A murine model of granulomatous colitis with mesenteric lymphadenitis induced by mycobacterial cord factor. ( 12596066 )
2003
26
Mesenteric adenitis: CT diagnosis of primary versus secondary causes, incidence, and clinical significance in pediatric and adult patients. ( 11906862 )
2002
27
Appendicitis-like syndrome owing to mesenteric adenitis caused by Salmonella typhi. ( 11926059 )
2002
28
Penicillium marneffei mesenteric lymphadenitis in human immunodeficiency virus-infected children. ( 9737118 )
1998
29
CT diagnosis of mesenteric adenitis. ( 8988204 )
1997
30
The etiology and clinical characteristics of mesenteric adenitis in Korean adults. ( 9170014 )
1997
31
Mesenteric adenitis caused by Yersinia pseudotuberculosis presenting as an abdominal mass. ( 9241511 )
1997
32
Tuberculous mesenteric lymphadenitis mimicking pancreatic carcinoma. ( 8975983 )
1996
33
Tuberculous mesenteric lymphadenitis presenting as pyloric stenosis. ( 7555442 )
1995
34
Six cases in which mesenteric lymphadenitis due to non-typhi Salmonella caused an appendicitis-like syndrome. ( 7578746 )
1995
35
Mesenteric lymphadenitis or appendicitis? ( 7618596 )
1995
36
A right lower abdominal mass due to Yersinia mesenteric lymphadenitis. ( 8008505 )
1994
37
Yersinia enterocolitica mesenteric adenitis suspected by ultrasound examination. ( 8018205 )
1994
38
A trematode (Phagicola sp.)-induced mesenteric lymphadenitis and enteritis in raccoons (Procyon lotor). ( 8212460 )
1993
39
Chylous ascites caused by Mycobacterium avium complex and mesenteric lymphadenitis in a child with the acquired immunodeficiency syndrome. ( 8417435 )
1993
40
Mesenteric lymphadenitis depicted by indium 111-labeled white blood cell imaging. ( 8301487 )
1993
41
Chronic intussusception associated with Yersinia enterocolitica mesenteric adenitis. ( 1469587 )
1992
42
Yersinia enterocolitica mesenteric adenitis in a thalassaemic adolescent. Conservative management. ( 1537358 )
1992
43
Acute mesenteric lymphadenitis due to Yersinia pseudotuberculosis lacking a virulence plasmid. ( 1864948 )
1991
44
Mesenteric lymphadenitis of swine caused by Rhodococcus sputi. ( 3343310 )
1988
45
Atypical mycobacterial mesenteric lymphadenitis in childhood presenting as an abdominal mass. ( 3418471 )
1988
46
Fibrinogen/fibrin deposits in mesenteric lymphadenitis due to Yersinia pseudotuberculosis type I: morphologic, immunohistochemical and electron microscopic studies of one case. ( 3539084 )
1986
47
Mesenteric adenitis and acute terminal ileitis: US evaluation using graded compression. ( 3538138 )
1986
48
Tuberculous mesenteric lymphadenitis clinically presenting as abdominal mass: CT and sonographic findings. ( 3932482 )
1985
49
Meningococcal mesenteric adenitis and peritonitis in a child. ( 6433327 )
1984
50
Nontropical chyluria secondary to massive mesenteric adenitis. Case report with metabolic and immunologic studies. ( 6475996 )
1984

Variations for Mesenteric Lymphadenitis

Expression for Mesenteric Lymphadenitis

Search GEO for disease gene expression data for Mesenteric Lymphadenitis.

Pathways for Mesenteric Lymphadenitis

Pathways related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 CD68 CRP EGF ERBB3 IL5 IL6
2
Show member pathways
13.02 EGF ERBB3 IL5 IL6 LBP MYD88
3
Show member pathways
12.79 IL6 LBP MYD88 NOD2 TLR2
4
Show member pathways
12.36 IL5 IL6 NOD2 TLR2
5
Show member pathways
12.17 EGF LBP MYD88 TLR2
6
Show member pathways
11.83 HSPD1 IL6 TLR2
7
Show member pathways
11.82 ERBB3 IL5 TLR2
8
Show member pathways
11.78 IL6 LBP MYD88 TLR2
9 11.75 CD68 IL5 IL6
10
Show member pathways
11.62 IL6 LBP MYD88
11
Show member pathways
11.57 CRP IL6 LBP
12 11.54 IL6 LBP MYD88
13 11.38 EGF IL5 IL6
14 11.35 HSPD1 IL6 LBP MYD88 NOD2 TLR2
15 11.19 IL6 MYD88 TLR2
16 11 HSPD1 IL6 MYD88 TLR2
17 10.9 MYD88 TLR2
18 10.85 CRP IL6

GO Terms for Mesenteric Lymphadenitis

Cellular components related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 AKR1B1 CRP EGF ERBB3 HSPD1 IL5

Biological processes related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.99 CRP LBP MYD88 NOD2 TLR2
2 cytokine-mediated signaling pathway GO:0019221 9.94 IL5 IL6 LBP MYD88
3 positive regulation of gene expression GO:0010628 9.91 CRP EGF ERBB3 IL6 MYD88 TLR2
4 inflammatory response GO:0006954 9.88 CRP IL5 IL6 MYD88 REG3A TLR2
5 response to lipopolysaccharide GO:0032496 9.87 HSPD1 LBP MYD88 TLR2
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 EGF IL5 IL6
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 AKR1B1 IL6 MYD88
8 toll-like receptor signaling pathway GO:0002224 9.72 LBP MYD88 TLR2
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 IL6 MYD88 NOD2 RIPK4 TLR2
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 LBP MYD88 TLR2
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.69 HSPD1 MYD88 TLR2
12 positive regulation of JAK-STAT cascade GO:0046427 9.67 AKR1B1 IL5 IL6
13 positive regulation of tumor necrosis factor production GO:0032760 9.67 LBP MYD88 NOD2 TLR2
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.66 MYD88 NOD2
15 positive regulation of macrophage activation GO:0043032 9.65 HSPD1 LBP
16 negative regulation of growth of symbiont in host GO:0044130 9.65 LBP MYD88
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 NOD2 TLR2
18 positive regulation of interleukin-10 production GO:0032733 9.65 HSPD1 NOD2 TLR2
19 positive regulation of interleukin-17 production GO:0032740 9.64 MYD88 NOD2
20 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL5 IL6
21 positive regulation of chemokine production GO:0032722 9.63 IL6 LBP TLR2
22 cellular response to lipoteichoic acid GO:0071223 9.62 LBP TLR2
23 negative regulation of lipid storage GO:0010888 9.61 CRP IL6
24 opsonization GO:0008228 9.6 CRP LBP
25 response to peptidoglycan GO:0032494 9.58 IL6 MYD88
26 negative regulation of secretion GO:0051048 9.56 EGF ERBB3
27 acute-phase response GO:0006953 9.56 CRP IL6 LBP REG3A
28 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP MYD88 TLR2
29 cytokine secretion involved in immune response GO:0002374 9.54 NOD2 TLR2
30 positive regulation of interleukin-8 production GO:0032757 9.26 LBP MYD88 NOD2 TLR2
31 positive regulation of interleukin-6 production GO:0032755 9.1 HSPD1 IL6 LBP MYD88 NOD2 TLR2
32 negative regulation of apoptotic process GO:0043066 10.02 AKR1B1 ERBB3 HSPD1 IL6 MYD88
33 positive regulation of cell proliferation GO:0008284 10.01 EGF IL5 IL6 NOD2 REG3A

Molecular functions related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 CRP ERBB3 MRAP MYD88 REG3A TLR2
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.58 EGF ERBB3 IL5
3 lipopeptide binding GO:0071723 9.26 LBP TLR2
4 Toll-like receptor binding GO:0035325 9.16 MYD88 TLR2
5 lipopolysaccharide binding GO:0001530 9.13 HSPD1 LBP TLR2
6 peptidoglycan binding GO:0042834 8.8 NOD2 REG3A TLR2
7 protein binding GO:0005515 10.21 CRP EGF ERBB3 HSPD1 IL5 IL6

Sources for Mesenteric Lymphadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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