MCID: MSN002
MIFTS: 38

Mesenteric Lymphadenitis

Categories: Immune diseases

Aliases & Classifications for Mesenteric Lymphadenitis

MalaCards integrated aliases for Mesenteric Lymphadenitis:

Name: Mesenteric Lymphadenitis 12 44 15 73
Mesenteric Adenitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10782
ICD10 33 I88.0
ICD9CM 35 289.2
MeSH 44 D008640
NCIt 50 C26830
UMLS 73 C0025469

Summaries for Mesenteric Lymphadenitis

MalaCards based summary : Mesenteric Lymphadenitis, also known as mesenteric adenitis, is related to appendicitis and ileitis. An important gene associated with Mesenteric Lymphadenitis is RIPK4 (Receptor Interacting Serine/Threonine Kinase 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include testes and lymph node, and related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Mesenteric Lymphadenitis

Diseases related to Mesenteric Lymphadenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 appendicitis 31.1 CRP IL6 LBP
2 ileitis 30.2 IL6 NOD2 TLR2
3 ulcerative colitis 30.0 CRP IL6 NOD2
4 suppurative otitis media 29.9 CRP TLR2
5 aortitis 10.8 CRP MRAP
6 inflammatory bowel disease 20 10.8 MRAP NOD2
7 pyuria 10.8 CRP MRAP
8 lymphadenitis 10.7
9 cold agglutinin disease 10.7 CRP IL6
10 tenosynovitis 10.7 CRP MRAP
11 cryopyrin-associated periodic syndrome 10.7 CRP IL6
12 cardiogenic shock 10.7 CRP IL6
13 acute cholangitis 10.6 CRP IL6
14 neutrophilia, hereditary 10.6 CRP IL6
15 bursitis 10.6 CRP MRAP
16 whipple disease 10.6 HSPD1 MRAP
17 palindromic rheumatism 10.5 CRP ERBB3 MRAP
18 uremic pruritus 10.5 CRP IL6
19 intestinal perforation 10.5 CRP NOD2
20 fox-fordyce disease 10.5 CD68 MRAP
21 castleman disease 10.5 CRP IL6
22 spondyloarthropathy 1 10.5 CRP MRAP NOD2
23 chronic meningitis 10.5 CRP IL5
24 spinal disease 10.5 CRP IL6 MRAP
25 periodontitis, chronic 10.5 IL6 TLR2
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL6
27 reactive arthritis 10.4 CRP HSPD1 IL6
28 bagassosis 10.4 IL5 IL6
29 tendinitis 10.4 CRP MRAP
30 bone inflammation disease 10.4 CRP IL6 MRAP
31 pelvic inflammatory disease 10.4 CRP HSPD1 TLR2
32 lethal congenital contracture syndrome 2 10.4 EGF ERBB3
33 anterior uveitis 10.4 IL6 TLR2
34 spondylitis 10.3 CRP IL6 NOD2
35 inflammatory bowel disease 4 10.3 IL5 NOD2
36 pericoronitis 10.3 CD68 CRP
37 arteriosclerosis 10.3 CRP HSPD1 IL6
38 gastrointestinal system disease 10.3 CRP IL6 NOD2
39 leprosy 3 10.3 HSPD1 NOD2 TLR2
40 leptospirosis 10.3 CRP IL6 TLR2
41 bacterial meningitis 10.3 CRP IL6 TLR2
42 multicentric castleman disease 10.2 CRP IL5 IL6
43 meningitis 10.2 CRP IL6 TLR2
44 periodontitis 10.2 CRP IL6 TLR2
45 psoriatic arthritis 10.2 CRP IL6 NOD2
46 urethritis 10.2 HSPD1 MRAP
47 crohn's disease 10.2 CRP IL6 NOD2
48 gastroenteritis 10.2 CRP IL5 IL6
49 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 CRP IL5 IL6
50 mycobacterium tuberculosis 1 10.2 HSPD1 MYD88 TLR2

Graphical network of the top 20 diseases related to Mesenteric Lymphadenitis:



Diseases related to Mesenteric Lymphadenitis

Symptoms & Phenotypes for Mesenteric Lymphadenitis

MGI Mouse Phenotypes related to Mesenteric Lymphadenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.76 MYD88 NOD2 RIPK4 TLR2 EGF ERBB3
2 growth/size/body region MP:0005378 9.7 AKR1B1 EGF ERBB3 HSPD1 IL5 IL6
3 immune system MP:0005387 9.36 CD68 CRP EGF ERBB3 IL5 IL6

Drugs & Therapeutics for Mesenteric Lymphadenitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies Recruiting NCT03349814

Search NIH Clinical Center for Mesenteric Lymphadenitis

Cochrane evidence based reviews: mesenteric lymphadenitis

Genetic Tests for Mesenteric Lymphadenitis

Anatomical Context for Mesenteric Lymphadenitis

MalaCards organs/tissues related to Mesenteric Lymphadenitis:

41
Testes, Lymph Node

Publications for Mesenteric Lymphadenitis

Articles related to Mesenteric Lymphadenitis:

(show top 50) (show all 91)
# Title Authors Year
1
Mesenteric lymphadenitis as a presenting feature of Whipple's disease. ( 28660130 )
2017
2
Acute Nonspecific Mesenteric Lymphadenitis: More Than "No Need for Surgery". ( 28261620 )
2017
3
Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. ( 27987102 )
2017
4
Course of acute nonspecific mesenteric lymphadenitis: single-center experience. ( 28913615 )
2017
5
Role of serum cytokines in acute appendicitis and acute mesenteric lymphadenitis among children. ( 27793542 )
2016
6
Is mesenteric lymphadenitis a cause of ovarian reserve reduction? - Case Report. ( 27203306 )
2016
7
A rare case of typhoid presenting with fever, ascites, hyponatremia, thrombocytopenia, mesenteric lymphadenitis, and multi-drug resistance. ( 26015752 )
2015
8
Mesenteric lymphadenitis caused by Yersinia enterocolitica. ( 26557944 )
2015
9
Two cases of abdominal pain in children with mesenteric lymphadenitis due to Yersinia pseudotuberculosis infection. ( 24793203 )
2014
10
Cryptococcal mesenteric lymphadenitis in an immunocompromised host. ( 22529459 )
2012
11
Clinical differentiation between acute appendicitis and acute mesenteric lymphadenitis in children. ( 21157689 )
2011
12
Appendicitis, mesenteric lymphadenitis, and subsequent risk of ulcerative colitis: cohort studies in Sweden and Denmark. ( 19273506 )
2009
13
Fatal mesenteric lymphadenitis in cattle caused by Listeria monocytogenes. ( 19122218 )
2009
14
A case of mesenteric lymphadenitis with long-acting symptom, showing marked response to corticosteroid. ( 17827909 )
2007
15
Tuberculous mesenteric lymphadenitis involving the gastric wall: case report. ( 16246704 )
2005
16
A palpable right lower abdominal mass due to Yersinia mesenteric lymphadenitis. ( 14770325 )
2004
17
Cryptococcal mesenteric lymphadenitis: an unusual cause of acute abdomen. ( 15316724 )
2004
18
A murine model of granulomatous colitis with mesenteric lymphadenitis induced by mycobacterial cord factor. ( 12596066 )
2003
19
Penicillium marneffei mesenteric lymphadenitis in human immunodeficiency virus-infected children. ( 9737118 )
1998
20
Tuberculous mesenteric lymphadenitis mimicking pancreatic carcinoma. ( 8975983 )
1996
21
Tuberculous mesenteric lymphadenitis presenting as pyloric stenosis. ( 7555442 )
1995
22
Six cases in which mesenteric lymphadenitis due to non-typhi Salmonella caused an appendicitis-like syndrome. ( 7578746 )
1995
23
Mesenteric lymphadenitis or appendicitis? ( 7618596 )
1995
24
A right lower abdominal mass due to Yersinia mesenteric lymphadenitis. ( 8008505 )
1994
25
A trematode (Phagicola sp.)-induced mesenteric lymphadenitis and enteritis in raccoons (Procyon lotor). ( 8212460 )
1993
26
Chylous ascites caused by Mycobacterium avium complex and mesenteric lymphadenitis in a child with the acquired immunodeficiency syndrome. ( 8417435 )
1993
27
Mesenteric lymphadenitis depicted by indium 111-labeled white blood cell imaging. ( 8301487 )
1993
28
Acute mesenteric lymphadenitis due to Yersinia pseudotuberculosis lacking a virulence plasmid. ( 1864948 )
1991
29
Mesenteric lymphadenitis of swine caused by Rhodococcus sputi. ( 3343310 )
1988
30
Atypical mycobacterial mesenteric lymphadenitis in childhood presenting as an abdominal mass. ( 3418471 )
1988
31
Fibrinogen/fibrin deposits in mesenteric lymphadenitis due to Yersinia pseudotuberculosis type I: morphologic, immunohistochemical and electron microscopic studies of one case. ( 3539084 )
1986
32
Tuberculous mesenteric lymphadenitis clinically presenting as abdominal mass: CT and sonographic findings. ( 3932482 )
1985
33
Staphylococcal suppurative mesenteric lymphadenitis. ( 6844204 )
1983
34
Tuberculous mesenteric lymphadenitis in children. ( 6866788 )
1983
35
Mesenteric lymphadenitis due to Yersinia enterocolitica. ( 7222465 )
1981
36
Mesenteric lymphadenitis due to Yersinia pseudotuberculosis: a case report. ( 7019789 )
1981
37
Suppurative mesenteric lymphadenitis in children. Case reports. ( 6457399 )
1981
38
Test and teach. Number twenty-six. Diagnosis: yersinia pseudotuberculosis acute mesenteric lymphadenitis. ( 7220096 )
1981
39
Different histologic types of mesenteric lymphadenitis in Yersinia pseudotuberculosis type I and type II infection. ( 356012 )
1978
40
Mesenteric lymphadenitis due to Yersinia pseudotuberculosis. ( 338553 )
1977
41
Terminal ileitis, mesenteric lymphadenitis and appendicitis due to Yersinia pseudotuberculosis type VA: case report. ( 1004946 )
1976
42
Suppurative mesenteric lymphadenitis, a forgotten clinical entity: report of two cases. ( 1202184 )
1975
43
Filarial mesenteric lymphadenitis with ileal perforation. ( 1104715 )
1975
44
Unusual Yersinia enterocolitica isolates not associated with mesenteric lymphadenitis. ( 4833285 )
1974
45
Acute mesenteric lymphadenitis due to Salmonella enteritidis mimicking appendicitis: case report. ( 4206946 )
1974
46
Tuberculous mesenteric lymphadenitis; with emphasis on angiographic findings. ( 4685865 )
1973
47
Yersinia pseudotuberculosis infection in the United States. Speticema, appendicitis, and mesenteric lymphadenitis. ( 5093665 )
1971
48
The association of mesenteric lymphadenitis with a scotochromogenic mycobacterium. ( 5089287 )
1971
49
Mesenteric lymphadenitis due to Yersinia enterocolitica: report of a case. ( 5554204 )
1971
50
Pasteurella pseudotuberculosis as a cause of suppurative mesenteric lymphadenitis. ( 5464483 )
1970

Variations for Mesenteric Lymphadenitis

Expression for Mesenteric Lymphadenitis

Search GEO for disease gene expression data for Mesenteric Lymphadenitis.

Pathways for Mesenteric Lymphadenitis

Pathways related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 CD68 CRP EGF ERBB3 IL5 IL6
2
Show member pathways
13.02 EGF ERBB3 IL5 IL6 LBP MYD88
3
Show member pathways
12.79 IL6 LBP MYD88 NOD2 TLR2
4
Show member pathways
12.18 EGF LBP MYD88 TLR2
5
Show member pathways
12.16 IL5 IL6 NOD2 TLR2
6
Show member pathways
11.82 ERBB3 IL5 TLR2
7
Show member pathways
11.78 IL6 LBP MYD88 TLR2
8 11.76 CD68 IL5 IL6
9
Show member pathways
11.64 IL6 LBP MYD88
10
Show member pathways
11.59 CRP IL6 LBP
11 11.57 IL6 LBP MYD88
12 11.38 EGF IL5 IL6
13 11.35 HSPD1 IL6 LBP MYD88 NOD2 TLR2
14 11.19 IL6 MYD88 TLR2
15 11 HSPD1 IL6 MYD88 TLR2
16 10.89 MYD88 TLR2
17 10.84 CRP IL6

GO Terms for Mesenteric Lymphadenitis

Cellular components related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 AKR1B1 CRP EGF ERBB3 HSPD1 IL5

Biological processes related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.95 IL5 IL6 LBP MYD88
2 positive regulation of gene expression GO:0010628 9.88 CRP EGF ERBB3 IL6 MYD88 TLR2
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 EGF IL5 IL6
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 IL6 MYD88 NOD2 RIPK4 TLR2
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.74 AKR1B1 IL6 MYD88
6 toll-like receptor signaling pathway GO:0002224 9.73 LBP MYD88 TLR2
7 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.7 HSPD1 MYD88 TLR2
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 LBP MYD88 TLR2
9 positive regulation of interleukin-8 production GO:0032757 9.67 LBP NOD2 TLR2
10 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.66 MYD88 NOD2
11 positive regulation of macrophage activation GO:0043032 9.65 HSPD1 LBP
12 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.65 NOD2 TLR2
13 positive regulation of JAK-STAT cascade GO:0046427 9.65 AKR1B1 IL5 IL6
14 negative regulation of growth of symbiont in host GO:0044130 9.64 LBP MYD88
15 negative regulation of ERBB signaling pathway GO:1901185 9.64 EGF ERBB3
16 positive regulation of interleukin-17 production GO:0032740 9.63 MYD88 NOD2
17 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL5 IL6
18 positive regulation of interleukin-10 production GO:0032733 9.63 HSPD1 NOD2 TLR2
19 cellular response to lipoteichoic acid GO:0071223 9.62 LBP TLR2
20 positive regulation of tumor necrosis factor production GO:0032760 9.62 LBP MYD88 NOD2 TLR2
21 positive regulation of chemokine production GO:0032722 9.61 IL6 LBP TLR2
22 negative regulation of lipid storage GO:0010888 9.59 CRP IL6
23 opsonization GO:0008228 9.58 CRP LBP
24 response to peptidoglycan GO:0032494 9.58 IL6 MYD88
25 acute-phase response GO:0006953 9.56 CRP IL6 LBP REG3A
26 negative regulation of secretion GO:0051048 9.55 EGF ERBB3
27 defense response to Gram-positive bacterium GO:0050830 9.55 CRP IL6 LBP MYD88 TLR2
28 cytokine secretion involved in immune response GO:0002374 9.54 NOD2 TLR2
29 inflammatory response GO:0006954 9.5 CRP IL5 IL6 MYD88 NOD2 REG3A
30 positive regulation of interleukin-6 production GO:0032755 9.1 HSPD1 IL6 LBP MYD88 NOD2 TLR2
31 negative regulation of apoptotic process GO:0043066 10.01 AKR1B1 ERBB3 HSPD1 IL6 MYD88
32 innate immune response GO:0045087 10 CRP LBP MYD88 NOD2 TLR2
33 positive regulation of cell proliferation GO:0008284 10 EGF IL5 IL6 NOD2 REG3A

Molecular functions related to Mesenteric Lymphadenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 EGF ERBB3 IL5
2 lipopeptide binding GO:0071723 9.26 LBP TLR2
3 Toll-like receptor binding GO:0035325 9.16 MYD88 TLR2
4 lipopolysaccharide binding GO:0001530 9.13 HSPD1 LBP TLR2
5 peptidoglycan binding GO:0042834 8.8 NOD2 REG3A TLR2

Sources for Mesenteric Lymphadenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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