MCID: MSN003
MIFTS: 33

Mesenteric Vascular Occlusion

Categories: Cardiovascular diseases

Aliases & Classifications for Mesenteric Vascular Occlusion

MalaCards integrated aliases for Mesenteric Vascular Occlusion:

Name: Mesenteric Vascular Occlusion 12 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13252
MeSH 44 D008641
UMLS 72 C0025472

Summaries for Mesenteric Vascular Occlusion

MalaCards based summary : Mesenteric Vascular Occlusion is related to thrombophilia due to thrombin defect and spinal cord infarction. An important gene associated with Mesenteric Vascular Occlusion is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Selenium Micronutrient Network and Warfarin Pathway, Pharmacodynamics. The drugs Heparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and heart, and related phenotypes are growth/size/body region and embryo

Related Diseases for Mesenteric Vascular Occlusion

Diseases related to Mesenteric Vascular Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 thrombophilia due to thrombin defect 29.8 MTHFR F2
2 spinal cord infarction 29.6 MTHFR F2
3 thrombophlebitis 29.5 MTHFR F2
4 varicose veins 29.2 MTHFR F2
5 disseminated intravascular coagulation 29.1 MB F7 F2
6 pleuropulmonary blastoma 10.4 MB FGF10
7 visual agnosia 10.2 MB F7
8 cervical intraepithelial neoplasia 10.1 ODC1 MTHFR
9 intestinal atresia 10.0
10 short bowel syndrome 10.0
11 vascular disease 10.0
12 peritonitis 10.0
13 intestinal obstruction 10.0
14 ileus 10.0
15 colorectal adenoma 10.0 ODC1 MTHFR
16 subendocardial myocardial infarction 10.0 MB F2
17 compartment syndrome 9.9 MB F2
18 carotid stenosis 9.9 MTHFR F7
19 prothrombin deficiency 9.9 F7 F2
20 anterior cranial fossa meningioma 9.9 F7 F2
21 colonic atresia 9.9
22 pulmonary disease, chronic obstructive 9.9
23 membranous nephropathy 9.9
24 pain agnosia 9.9
25 inguinal hernia 9.9
26 mumps 9.9
27 bacterial infectious disease 9.9
28 respiratory failure 9.9
29 diarrhea 9.9
30 acquired polycythemia 9.9
31 glomerulonephritis 9.9
32 paraplegia 9.9
33 polycythemia 9.9
34 paralytic ileus 9.9
35 intestinal volvulus 9.9
36 macroglobulinemia 9.9
37 polyarteritis nodosa 9.9
38 hemophilia 9.9 F7 F2
39 intestinal benign neoplasm 9.9 ODC1 MTHFR LGR5
40 inherited blood coagulation disease 9.9 F7 F2
41 cavernous hemangioma 9.8 MB F2
42 sudden sensorineural hearing loss 9.8 MTHFR F2
43 ischemic neuropathy 9.8 MTHFR F2
44 cryptogenic cirrhosis 9.8 MTHFR F2
45 hemophilia b 9.8 F7 F2
46 porencephaly 9.8 MTHFR F2
47 factor vii deficiency 9.8 F7 F2
48 marantic endocarditis 9.8 MTHFR F2
49 livedoid vasculitis 9.8 MTHFR F2
50 retinal vascular occlusion 9.8 MTHFR F2

Graphical network of the top 20 diseases related to Mesenteric Vascular Occlusion:



Diseases related to Mesenteric Vascular Occlusion

Symptoms & Phenotypes for Mesenteric Vascular Occlusion

MGI Mouse Phenotypes related to Mesenteric Vascular Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.8 F2 F7 FGF10 LGR5 MB MTHFR
2 embryo MP:0005380 9.72 F2 FGF10 HOPX MB ODC1
3 homeostasis/metabolism MP:0005376 9.7 F2 F7 FGF10 HOPX LGR5 MB
4 mortality/aging MP:0010768 9.56 F2 F7 FGF10 HOPX LGR5 MB
5 respiratory system MP:0005388 9.02 F2 FGF10 HOPX LGR5 MB

Drugs & Therapeutics for Mesenteric Vascular Occlusion

Drugs for Mesenteric Vascular Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Dalteparin Approved Phase 4 9005-49-6
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Fibrinolytic Agents Phase 4
5 Heparin, Low-Molecular-Weight Phase 4
6 Anticoagulants Phase 4
7 calcium heparin Phase 4
8 Calcium, Dietary Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Predictive Factors of Intestinal Infraction in Patients With Acute Mesenteric Ischemia Completed NCT02645240 Phase 4 Heparin injection

Search NIH Clinical Center for Mesenteric Vascular Occlusion

Cochrane evidence based reviews: mesenteric vascular occlusion

Genetic Tests for Mesenteric Vascular Occlusion

Anatomical Context for Mesenteric Vascular Occlusion

MalaCards organs/tissues related to Mesenteric Vascular Occlusion:

41
Small Intestine, Colon, Heart, Testes, Kidney, Spinal Cord

Publications for Mesenteric Vascular Occlusion

Articles related to Mesenteric Vascular Occlusion:

(show top 50) (show all 204)
# Title Authors PMID Year
1
Preservation of reserve intestinal epithelial stem cells following severe ischemic injury. 38
30714814 2019
2
A rare cause of acute abdomen in the ED: Chemotherapy-induced pneumatosis intestinalis. 38
29464220 2017
3
Rectus sheath block for postoperative analgesia in patients with mesenteric vascular occlusion undergoing laparotomy: A randomized single-blinded study. 38
27746544 2016
4
Early computed tomography in victims of non-traumatic out-of-hospital cardiac arrest. 38
26597877 2016
5
Associated factors for non-ischemic serum myoglobin release after cardiac surgical procedures. 38
25002394 2014
6
Mesenteric vascular occlusion: comparison of ancillary CT findings between arterial and venous occlusions and independent CT findings suggesting life-threatening events. 38
23323029 2013
7
Factors affecting mortality and morbidity in emergency abdominal surgery in geriatric patients. 38
21038122 2010
8
Partial splenic embolization versus splenectomy for the management of hypersplenism in cirrhotic patients. 38
19513783 2009
9
Serum ischaemia-modified albumin increases in critical lower limb ischaemia. 38
18499817 2008
10
Management of mesenteric vascular occlusion. 38
18418524 2008
11
Intestinal gangrene due to mesenteric vascular occlusion masquerading as strangulated inguinal hernia. 38
17687510 2008
12
[Acute mesenteric vascular occlusion, 4 year experiance in Sarajevo Clinical Centar of University (2004-2007)]. 38
18669232 2008
13
Spinal cord infarction following surgery for mesenteric vascular occlusion. 38
18046296 2007
14
Thrombolysis via an operatively placed mesenteric catheter for portal and superior mesenteric vein thrombosis: report of a case. 38
16937294 2006
15
Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. 38
15750935 2005
16
Portal vein thrombosis after laparoscopic sigmoid colectomy for diverticulitis: report of a case. 38
12682554 2003
17
Acute intestinal ischemia and infarction. 38
12889581 2003
18
Abdominal surgical emergency in the elderly. 38
16378274 2002
19
Inherited thrombophilia: a possible cause of in utero vascular thrombosis in children with intestinal atresia. 38
11479844 2001
20
Effect of prolonged selective intramesenteric arterial vasodilator therapy on intestinal viability after acute segmental mesenteric vascular occlusion. 38
11420490 2001
21
Mesenteric vascular occlusion resulting in intestinal necrosis in children. 38
10945686 2000
22
Idiopathic mesenteric thrombosis following caesarean section. 38
10540780 1999
23
[Severe ischemic colitis in a patient with acute myocardial infarction]. 38
10422300 1999
24
Acute mesenteric vascular occlusion: analysis of 39 patients. 38
9562280 1998
25
Preventive administration of ornithine alpha-ketoglutarate improves intestinal mucosal repair after transient ischemia in rats. 38
9428553 1998
26
[Fatal outcome factors of intestinal infarct of primary vascular origin]. 38
9498203 1997
27
[Acute mesenteric vascular occlusion: the importance of the venous phase in angiography]. 38
8924333 1996
28
[Long-term parenteral nutrition in vascular-induced short bowel syndrome]. 38
8717174 1996
29
[Diagnosis and prognosis of mesenterial infarct]. 38
8164598 1994
30
Intraluminal "balloonless" air tonometry: a new method for determination of gastrointestinal mucosal carbon dioxide tension. 38
8124955 1994
31
Polyamines and the recovery of intestinal morphology and function after ischemic damage in rats. 38
8174830 1994
32
Adenine nucleotides of ischemic intestine do not reflect injury. 38
8412129 1993
33
[A prospective study for evaluating postoperative risk and long-term prognosis of mesenteric infarct]. 38
2056985 1991
34
[Sensitivity of preoperative diagnosis in mesenteric vascular occlusion]. 38
1797247 1991
35
[Value of preoperative diagnosis in mesenteric vascular occlusion. A prospective study]. 38
2259261 1990
36
[Acute mesenteric vascular occlusion: pathophysiology, clinical stages, diagnosis]. 38
1983561 1990
37
[Indications and results of second-look operation in acute mesenteric vascular occlusion]. 38
1983564 1990
38
Pneumatosis cystoides intestinalis and intramural intestinal gas. 38
2696753 1989
39
Mesenteric vascular occlusion: a new diagnostic method using a radiolabeled monoclonal antibody reactive with platelets. 38
2717735 1989
40
Intraoperative assessment of blood flow and tissue viability in small-bowel ischemia by laser Doppler flowmetry. 38
2683534 1989
41
[Characteristics of the microcirculation and blood rheology in arterial and venous forms of mesenteric vascular occlusion]. 38
2736278 1989
42
Laser Doppler flowmetry in experimental mesenteric vascular occlusion. 38
2659544 1989
43
Prognostic factors in intestinal gangrene. 38
2718252 1989
44
Failure of ornithine decarboxylase inhibition to alter small intestinal epithelial repair after transient segmental ischaemia. 38
3135252 1988
45
Acute intestinal infarction or obstruction: search for better laboratory tests in an animal model. 38
2963710 1988
46
Gastrointestinal application of laser Doppler flowmetry. An experimental and clinical study in cat and man. 38
3048026 1988
47
Computed tomography of bowel infarction. 38
3655039 1987
48
The rationale for "second-look operation" in mesenteric vessel occlusion with uncertain intestinal viability at primary surgery. 38
3425101 1987
49
[Intestinal infarction without mesenteric vascular occlusion after open heart surgery: a case report]. 38
3668345 1987
50
Use of trans-serosal PO2 to determine intestinal viability in acute mesenteric vascular occlusion. 38
3595206 1987

Variations for Mesenteric Vascular Occlusion

Expression for Mesenteric Vascular Occlusion

Search GEO for disease gene expression data for Mesenteric Vascular Occlusion.

Pathways for Mesenteric Vascular Occlusion

Pathways related to Mesenteric Vascular Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 MTHFR F7 F2
2 9.8 F7 F2

GO Terms for Mesenteric Vascular Occlusion

Biological processes related to Mesenteric Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell differentiation GO:0045596 9.32 HOPX FGF10
2 response to hormone GO:0009725 9.26 MB F7
3 hemostasis GO:0007599 9.16 F7 F2
4 response to hypoxia GO:0001666 9.13 MTHFR MB F7
5 positive regulation of blood coagulation GO:0030194 8.62 F7 F2

Sources for Mesenteric Vascular Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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