MCID: MSL004
MIFTS: 27

Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards integrated aliases for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

Name: Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis 59 37
Mtle-Hs 59

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA99701
KEGG 37 H01826

Summaries for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards based summary : Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis, also known as mtle-hs, is related to temporal lobe epilepsy and epilepsy. An important gene associated with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Toxoplasmosis and Tuberculosis. Affiliated tissues include temporal lobe, cortex and brain.

Related Diseases for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 temporal lobe epilepsy 11.2
2 epilepsy 11.2
3 epilepsy, idiopathic generalized 10 10.3
4 cysticercosis 10.3
5 eclampsia 10.3
6 febrile seizures 10.3
7 actinic prurigo 10.0 HLA-DRB1 IL1B
8 post-traumatic stress disorder 10.0 APOE IL1B
9 central nervous system vasculitis 10.0 HLA-DRB1 IL1B
10 sleep apnea 10.0 APOE IL1B
11 acute disseminated encephalomyelitis 10.0 HLA-DRB1 IL1B
12 dengue shock syndrome 10.0 HLA-DRB1 IL1B
13 palindromic rheumatism 10.0 HLA-DRB1 IL1B
14 idiopathic neutropenia 10.0 HLA-DRB1 IL1B
15 autoimmune disease of central nervous system 10.0 HLA-DRB1 IL1B
16 cerebral palsy 10.0 APOE IL1B
17 autoimmune disease of the nervous system 10.0 HLA-DRB1 IL1B
18 bone inflammation disease 10.0 HLA-DRB1 IL1B
19 aortic aneurysm, familial abdominal, 1 10.0 APOE IL1B
20 arteries, anomalies of 10.0 APOE IL1B
21 juvenile rheumatoid arthritis 10.0 HLA-DRB1 IL1B
22 graft-versus-host disease 10.0 HLA-DRB1 IL1B
23 immune system disease 9.9 HLA-DRB1 IL1B
24 rheumatic disease 9.9 HLA-DRB1 IL1B
25 sarcoidosis 1 9.9 HLA-DRB1 IL1B
26 psoriatic arthritis 9.9 HLA-DRB1 IL1B
27 nervous system disease 9.9 APOE IL1B
28 leishmaniasis 9.9 HLA-DRB1 IL1B
29 central nervous system disease 9.9 APOE IL1B
30 macular degeneration, age-related, 1 9.9 APOE IL1B
31 multiple sclerosis 9.8 APOE HLA-DRB1 IL1B
32 hepatitis c virus 9.8 APOE HLA-DRB1

Graphical network of the top 20 diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:



Diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Symptoms & Phenotypes for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Drugs & Therapeutics for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Search Clinical Trials , NIH Clinical Center for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Genetic Tests for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Anatomical Context for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards organs/tissues related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

41
Temporal Lobe, Cortex, Brain, Cingulate Cortex, Bone

Publications for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Articles related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

(show top 50) (show all 66)
# Title Authors Year
1
Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29247965 )
2018
2
Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29904720 )
2018
3
Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis. ( 29651571 )
2018
4
Commentary on Nóbrega-Jr et al. "Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal antibodies". ( 30451294 )
2018
5
Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal autoantibodies. ( 30146688 )
2018
6
Symmetric tract-based spatial statistics of patients with left versus right mesial temporal lobe epilepsy with hippocampal sclerosis. ( 30113923 )
2018
7
Parahippocampal Involvement in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A Proof of Concept from Memory-Guided Saccades. ( 29163352 )
2017
8
MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. ( 28815576 )
2017
9
Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28941835 )
2017
10
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28857179 )
2017
11
Immunogenetic Predisposing Factors for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28675059 )
2017
12
Morphometric MRI features are associated with surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28324681 )
2017
13
Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 29094314 )
2017
14
Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28104639 )
2017
15
Age of onset of mesial temporal lobe epilepsy with hippocampal sclerosis: the effect of apolipoprotein E and febrile seizures. ( 27875923 )
2017
16
Is 'burned-out hippocampus' syndrome a distinct electro-clinical variant of MTLE-HS syndrome? ( 28235654 )
2017
17
Mesial temporal lobe epilepsy with hippocampal sclerosis as a neuroimmunological disorder. ( 27170276 )
2016
18
Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27926529 )
2016
19
Clinical and electrophysiological findings in mesial temporal lobe epilepsy with hippocampal sclerosis, based on the recent histopathological classifications. ( 27561188 )
2016
20
Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27842262 )
2016
21
Electrophysiological resting-state biomarker for diagnosing mesial temporal lobe epilepsy with hippocampal sclerosis. ( 28043064 )
2016
22
Neuronal autoantibodies in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27151964 )
2016
23
Brain Infiltration of Immune Cells in CASPR2-Antibody Associated Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28360810 )
2016
24
More Severe Extratemporal Damages in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis Than That With Other Lesions: A Multimodality MRI Study. ( 26962820 )
2016
25
The effect of transcranial direct current stimulation on seizure frequency of patients with mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27450765 )
2016
26
Evaluation of Glutamic Acid Decarboxylase Antibody Levels in Patients with Juvenile Myoclonic Epilepsy and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. ( 28373803 )
2016
27
Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 27995064 )
2016
28
RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS. ( 27094248 )
2016
29
Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. ( 25809843 )
2015
30
Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis. ( 26328621 )
2015
31
Neuroimaging observations linking neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis. ( 26354165 )
2015
32
Complete seizure freedom is possible in patients with MTLE-HS after surgery in spite of extratemporal electro-clinical features. ( 25986197 )
2015
33
Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 24962348 )
2014
34
Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. ( 23771402 )
2014
35
A critical evaluation of the lateralizing significance of material-specific memory deficits in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. ( 23891768 )
2013
36
Altered hemispheric symmetry found in left-sided mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE/HS) but not found in right-sided MTLE/HS. ( 22925605 )
2013
37
Periodic epileptiform discharges in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 23787169 )
2013
38
Whole mitochondrial DNA variations in hippocampal surgical specimens and blood samples with high-throughput sequencing: a case of mesial temporal lobe epilepsy with hippocampal sclerosis. ( 23872536 )
2013
39
Mesial temporal lobe epilepsy with hippocampal sclerosis preceded by eclampsia: a rare association. ( 24005737 )
2013
40
A quadruple examination of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis: onset, propagation, later significant pattern, and termination. ( 23912569 )
2013
41
Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 23751308 )
2013
42
Antiepileptic drugs management and long-term seizure outcome in post surgical mesial temporal lobe epilepsy with hippocampal sclerosis. ( 22336897 )
2012
43
Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis. ( 22497612 )
2012
44
Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 22510097 )
2012
45
Sexual desire and satisfaction after resective surgery in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. ( 23103313 )
2012
46
Mesial temporal lobe epilepsy with hippocampal sclerosis in two pairs of identical twins. ( 22794520 )
2012
47
Mesial temporal lobe epilepsy with hippocampal sclerosis: study of 42 children. ( 21112221 )
2011
48
Analysis of reoperation in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 21099715 )
2011
49
Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. ( 22937234 )
2011
50
How frequent is the association of neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis? ( 20977472 )
2010

Variations for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Expression for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Search GEO for disease gene expression data for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.

Pathways for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Pathways related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.68 HLA-DRB1 IL1B
2 11.62 HLA-DRB1 IL1B
3
Show member pathways
11.37 HLA-DRB1 IL1B
4 11.24 HLA-DRB1 IL1B
5 11.11 HLA-DRB1 IL1B
6 10.61 APOE IL1B
7 10.09 HLA-DRB1 IL1B

GO Terms for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Cellular components related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.26 APOE HLA-DRB1 IL1B MVP
2 clathrin-coated endocytic vesicle membrane GO:0030669 8.62 APOE HLA-DRB1

Biological processes related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of MAP kinase activity GO:0043407 8.96 APOE IL1B
2 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 APOE IL1B

Sources for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....