MCID: MSL004
MIFTS: 26

Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards integrated aliases for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

Name: Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis 58 36
Mtle-Hs 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

KEGG 36 H01826
Orphanet 58 ORPHA99701

Summaries for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

KEGG : 36 Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a group of chronic disorders characterized by prominent neuronal loss and gliosis in the hippocampus and amygdala. MTLE-HS is restricted to patients in whom hippocampal atrophy and/or abnormal signal intensity on MRI, anterior temporal interictal epileptiform discharges, and additional evidence of temporal dysfunction on functional images and neuro-psychological assessment are demonstrated.Patients with MTLE-HS often have a history of early risk factors such as febrile seizures, status epilepticus (SE) or infection. A seizure-free period may ensue before uncontrolled partial seizures begin. Epileptic focus is located deeply in the mesial temporal region including mainly hippocampus, parahippocampal gyrus and amygdala. The anatomopathological hallmark is sclerosis of the hippocampus. MTLE-HS is restricted to patients in whom hippocampal atrophy and/or abnormal signal intensity on MRI, anterior temporal interictal epileptiform discharges, and additional evidence of temporal dysfunction on functional images and neuro-psychological assessment are demonstrated. Since most of the cases are drug resistant, epilepsy surgery is the current gold standard therapy option for cessation of seizures. Familial forms of MTLE-HS have been recognized, but no causal gene has been identified so far.

MalaCards based summary : Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis, also known as mtle-hs, is related to temporal lobe epilepsy and epilepsy. An important gene associated with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are IL12-mediated signaling events and Hematopoietic cell lineage. Affiliated tissues include temporal lobe, amygdala and cortex.

Related Diseases for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 temporal lobe epilepsy 11.3
2 epilepsy 11.2
3 febrile seizures 10.7
4 seizure disorder 10.7
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
6 status epilepticus 10.6
7 focal epilepsy 10.6
8 hand skill, relative 10.5
9 epilepsy, myoclonic juvenile 10.5
10 cysticercosis 10.5
11 early myoclonic encephalopathy 10.5
12 ataxia and polyneuropathy, adult-onset 10.3
13 epilepsy, idiopathic generalized 10.3
14 sexual disorder 10.3
15 limbic encephalitis 10.3
16 eclampsia 10.3
17 encephalitis 10.3
18 48,xyyy 10.3
19 autoimmune encephalitis 10.3
20 idiopathic nephrotic syndrome 10.1 HLA-DRB1 APOE
21 herpes zoster 10.1 HLA-DRB1 APOE
22 primary progressive multiple sclerosis 10.1 HLA-DRB1 APOE
23 inclusion body myositis 10.0 HLA-DRB1 APOE
24 traumatic brain injury 9.9 IL1B APOE
25 brain injury 9.9 IL1B APOE
26 chlamydia pneumonia 9.9 IL1B APOE
27 cerebral artery occlusion 9.9 IL1B APOE
28 apnea, obstructive sleep 9.9 IL1B APOE
29 degeneration of macula and posterior pole 9.9 IL1B APOE
30 intrahepatic cholestasis of pregnancy 9.9 HLA-DRB1 APOE
31 actinic prurigo 9.9 IL1B HLA-DRB1
32 palindromic rheumatism 9.9 IL1B HLA-DRB1
33 idiopathic neutropenia 9.9 IL1B HLA-DRB1
34 central nervous system vasculitis 9.9 IL1B HLA-DRB1
35 autoimmune gastritis 9.9 IL1B HLA-DRB1
36 acute disseminated encephalomyelitis 9.9 IL1B HLA-DRB1
37 pharyngitis 9.9 IL1B HLA-DRB1
38 cicatricial pemphigoid 9.9 IL1B HLA-DRB1
39 churg-strauss syndrome 9.9 IL1B HLA-DRB1
40 dengue shock syndrome 9.9 IL1B HLA-DRB1
41 rheumatic heart disease 9.9 IL1B HLA-DRB1
42 cryoglobulinemia 9.9 IL1B HLA-DRB1
43 hypersensitivity reaction type iv disease 9.9 IL1B HLA-DRB1
44 toxic encephalopathy 9.9 IL1B APOE
45 aphthous stomatitis 9.9 IL1B HLA-DRB1
46 neuromyelitis optica 9.9 IL1B HLA-DRB1
47 graft-versus-host disease 9.9 IL1B HLA-DRB1
48 typhoid fever 9.9 IL1B HLA-DRB1
49 optic neuritis 9.9 IL1B HLA-DRB1
50 sleep apnea 9.9 IL1B APOE

Graphical network of the top 20 diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:



Diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Symptoms & Phenotypes for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Drugs & Therapeutics for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Search Clinical Trials , NIH Clinical Center for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Genetic Tests for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Anatomical Context for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards organs/tissues related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

40
Temporal Lobe, Amygdala, Cortex, Bone Marrow, Cerebellum, Cingulate Cortex, Thalamus

Publications for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Articles related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

(show top 50) (show all 248)
# Title Authors PMID Year
1
AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone. 61
33404979 2021
2
Quality of life long after temporal lobe epilepsy surgery. 61
33751549 2021
3
Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease. 61
33722437 2021
4
The Thalamic and Intracortical Inhibitory Function of Somatosensory System Is Unchanged in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis. 61
33675312 2021
5
VIPergic neuroprotection in epileptogenesis: challenges and opportunities. 61
33338622 2021
6
Ictal fear is associated with anxiety symptoms and interictal dysphoric disorder in drug-resistant mesial temporal lobe epilepsy. 61
33348195 2021
7
Electrical Stimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study. 61
33113540 2021
8
Proteomic profile differentiating between mesial temporal lobe epilepsy with and without hippocampal sclerosis. 61
33197783 2020
9
Role of Altered Expression, Activity and Sub-cellular Distribution of Various Histone Deacetylases (HDACs) in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
33258018 2020
10
How predictable is cognitive performance in Brazilian patients with pharmacoresistant mesial temporal lobe epilepsy? 61
33181899 2020
11
Expression of circulating microRNAs as predictors of diagnosis and surgical outcome in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
32682279 2020
12
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes. 61
32731050 2020
13
Neuropsychological findings related to the presence of pre-surgical comorbid depression in Latin-American patients with mesial temporal lobe epilepsy and hippocampal sclerosis. 61
32771825 2020
14
Voxel-based morphometry analysis and machine learning based classification in pediatric mesial temporal lobe epilepsy with hippocampal sclerosis. 61
31250266 2020
15
Altered coupling between resting-state glucose metabolism and functional activity in epilepsy. 61
32860354 2020
16
Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). 61
32543742 2020
17
α7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 61
32770411 2020
18
The Relationship Between Clinico-Pathological Properties and p-Glycoprotein Expression in Hippocampal Sclerosis Among Patients with Mesial Temporal Lobe Epilepsy Who Undergo Selective Amygdalohippocampectomy Operation. 61
32952422 2020
19
Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. 61
32111564 2020
20
Untargeted lipidomic analysis of human hippocampus for temporal lobe epilepsy with hippocampal sclerosis. 61
32105993 2020
21
Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances. 61
32157145 2020
22
Social impairment and stigma in genetic generalized epilepsies. 61
31931462 2020
23
Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. 61
29880883 2020
24
On brain atlas choice and automatic segmentation methods: a comparison of MAPER & FreeSurfer using three atlas databases. 61
32071355 2020
25
"Benign" temporal lobe epilepsy with hippocampal sclerosis: A forgotten entity? 61
33313502 2020
26
Plasma Exosomal MiRNAs Expression Profile in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis: Case-Control Study and Analysis of Potential Functions. 61
33240042 2020
27
Differential Glial Activation in Early Epileptogenesis-Insights From Cell-Specific Analysis of DNA Methylation and Gene Expression in the Contralateral Hippocampus. 61
33312155 2020
28
VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy. 61
32595454 2020
29
Epilepsy miRNA Profile Depends on the Age of Onset in Humans and Rats. 61
33041753 2020
30
Abnormalities of Cortical Thickness in Pediatric Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
33135613 2020
31
Expression of MicroRNAs miR-145, miR-181c, miR-199a and miR-1183 in the Blood and Hippocampus of Patients with Mesial Temporal Lobe Epilepsy. 61
31368064 2019
32
Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression. 61
31208877 2019
33
Investigation of Generalized EEG Paroxysms Accompanying Focal Epilepsies. 61
31248273 2019
34
Optimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis. 61
31521052 2019
35
Magnetic resonance fingerprinting of temporal lobe white matter in mesial temporal lobe epilepsy. 61
31359636 2019
36
Revisiting personality in epilepsy: Differentiation of personality in two epilepsies starting in adolescence. 61
31195327 2019
37
Transcriptomic and genetic analyses reveal potential causal drivers for intractable partial epilepsy. 61
30932156 2019
38
Follow-up of patients with epilepsy harboring antiglycine receptor antibodies. 61
30641251 2019
39
Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A) and The State-Trait Anxiety Inventory (STAI) accuracy for anxiety disorders detection in drug-resistant mesial temporal lobe epilepsy patients. 61
30599368 2019
40
The Dilemma of the Chicken or the Egg-What Appears First in TLE-Seizures or Morphometric Changes in the Temporal Lobe? 61
30955428 2019
41
Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study. 61
30324623 2019
42
Reduced Interhemispheric White Matter Asymmetries in Medial Temporal Lobe Epilepsy With Hippocampal Sclerosis. 61
31068889 2019
43
Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients. 61
30587513 2019
44
Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy. 61
30576963 2019
45
Commentary on Nóbrega-Jr et al. "Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal antibodies". 61
30451294 2018
46
The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis. 61
30248630 2018
47
Meta-analysis of voxel-based morphometry studies of gray matter abnormalities in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis. 61
29302917 2018
48
Symmetric tract-based spatial statistics of patients with left versus right mesial temporal lobe epilepsy with hippocampal sclerosis. 61
30113923 2018
49
Hippocampal activations in mesial temporal lobe epilepsy due to hippocampal sclerosis- an observational study on intramural encoding-delayed recall paradigms using task-based memory fMRI. 61
29859335 2018
50
Is self-report sleepiness associated with cognitive performance in temporal lobe epilepsy? 61
30365619 2018

Variations for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Expression for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Search GEO for disease gene expression data for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.

Pathways for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Pathways related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.37 IL1B HLA-DRB1
2 11.25 IL1B HLA-DRB1
3 11.12 IL1B HLA-DRB1
4 10.61 IL1B APOE
5 10.09 IL1B HLA-DRB1

GO Terms for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Cellular components related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin-coated endocytic vesicle membrane GO:0030669 8.62 HLA-DRB1 APOE

Biological processes related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.33 IL1B HLA-DRB1 APOE
2 negative regulation of MAP kinase activity GO:0043407 8.96 IL1B APOE
3 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 IL1B APOE

Sources for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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