MCID: MSL004
MIFTS: 26

Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards integrated aliases for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

Name: Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis 58 36
Mtle-Hs 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

KEGG 36 H01826
Orphanet 58 ORPHA99701

Summaries for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

KEGG : 36 Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a group of chronic disorders characterized by prominent neuronal loss and gliosis in the hippocampus and amygdala. MTLE-HS is restricted to patients in whom hippocampal atrophy and/or abnormal signal intensity on MRI, anterior temporal interictal epileptiform discharges, and additional evidence of temporal dysfunction on functional images and neuro-psychological assessment are demonstrated.Patients with MTLE-HS often have a history of early risk factors such as febrile seizures, status epilepticus (SE) or infection. A seizure-free period may ensue before uncontrolled partial seizures begin. Epileptic focus is located deeply in the mesial temporal region including mainly hippocampus, parahippocampal gyrus and amygdala. The anatomopathological hallmark is sclerosis of the hippocampus. MTLE-HS is restricted to patients in whom hippocampal atrophy and/or abnormal signal intensity on MRI, anterior temporal interictal epileptiform discharges, and additional evidence of temporal dysfunction on functional images and neuro-psychological assessment are demonstrated. Since most of the cases are drug resistant, epilepsy surgery is the current gold standard therapy option for cessation of seizures. Familial forms of MTLE-HS have been recognized, but no causal gene has been identified so far.

MalaCards based summary : Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis, also known as mtle-hs, is related to temporal lobe epilepsy and epilepsy. An important gene associated with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are IL12-mediated signaling events and Hematopoietic cell lineage. Affiliated tissues include temporal lobe, amygdala and cortex.

Related Diseases for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 85, show less)
# Related Disease Score Top Affiliating Genes
1 temporal lobe epilepsy 11.3
2 epilepsy 11.2
3 febrile seizures 10.7
4 seizure disorder 10.7
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
6 status epilepticus 10.6
7 focal epilepsy 10.6
8 hand skill, relative 10.5
9 epilepsy, myoclonic juvenile 10.5
10 cysticercosis 10.5
11 early myoclonic encephalopathy 10.5
12 ataxia and polyneuropathy, adult-onset 10.3
13 epilepsy, idiopathic generalized 10.3
14 sexual disorder 10.3
15 limbic encephalitis 10.3
16 eclampsia 10.3
17 encephalitis 10.3
18 48,xyyy 10.3
19 autoimmune encephalitis 10.3
20 idiopathic nephrotic syndrome 10.1 HLA-DRB1 APOE
21 cervical dystonia 10.1 HLA-DRB1 APOE
22 herpes zoster 10.1 HLA-DRB1 APOE
23 primary progressive multiple sclerosis 10.1 HLA-DRB1 APOE
24 inclusion body myositis 10.0 HLA-DRB1 APOE
25 traumatic brain injury 9.9 IL1B APOE
26 brain injury 9.9 IL1B APOE
27 chlamydia pneumonia 9.9 IL1B APOE
28 cerebral artery occlusion 9.9 IL1B APOE
29 apnea, obstructive sleep 9.9 IL1B APOE
30 degeneration of macula and posterior pole 9.9 IL1B APOE
31 intrahepatic cholestasis of pregnancy 9.9 HLA-DRB1 APOE
32 actinic prurigo 9.9 IL1B HLA-DRB1
33 palindromic rheumatism 9.9 IL1B HLA-DRB1
34 idiopathic neutropenia 9.9 IL1B HLA-DRB1
35 central nervous system vasculitis 9.9 IL1B HLA-DRB1
36 autoimmune gastritis 9.9 IL1B HLA-DRB1
37 acute disseminated encephalomyelitis 9.9 IL1B HLA-DRB1
38 pharyngitis 9.9 IL1B HLA-DRB1
39 cicatricial pemphigoid 9.9 IL1B HLA-DRB1
40 churg-strauss syndrome 9.9 IL1B HLA-DRB1
41 dengue shock syndrome 9.9 IL1B HLA-DRB1
42 rheumatic heart disease 9.9 IL1B HLA-DRB1
43 cryoglobulinemia 9.9 IL1B HLA-DRB1
44 hypersensitivity reaction type iv disease 9.9 IL1B HLA-DRB1
45 toxic encephalopathy 9.9 IL1B APOE
46 aphthous stomatitis 9.9 IL1B HLA-DRB1
47 neuromyelitis optica 9.9 IL1B HLA-DRB1
48 graft-versus-host disease 9.9 IL1B HLA-DRB1
49 typhoid fever 9.9 IL1B HLA-DRB1
50 optic neuritis 9.9 IL1B HLA-DRB1
51 sleep apnea 9.9 IL1B APOE
52 pneumoconiosis 9.9 IL1B HLA-DRB1
53 duodenal ulcer 9.9 IL1B HLA-DRB1
54 intracranial berry aneurysm 9.9 IL1B APOE
55 temporal arteritis 9.9 IL1B HLA-DRB1
56 arteriovenous malformation 9.9 IL1B APOE
57 myositis 9.8 IL1B HLA-DRB1
58 sleep disorder 9.8 IL1B APOE
59 lyme disease 9.8 IL1B HLA-DRB1
60 mumps 9.8 IL1B HLA-DRB1
61 post-traumatic stress disorder 9.8 IL1B APOE
62 thyroiditis 9.8 IL1B HLA-DRB1
63 reactive arthritis 9.8 IL1B HLA-DRB1
64 vascular dementia 9.8 IL1B APOE
65 rubella 9.8 IL1B HLA-DRB1
66 atrophic gastritis 9.8 IL1B HLA-DRB1
67 leprosy 3 9.8 IL1B HLA-DRB1
68 aortic aneurysm, familial abdominal, 1 9.8 IL1B APOE
69 alopecia areata 9.8 IL1B HLA-DRB1
70 juvenile rheumatoid arthritis 9.8 IL1B HLA-DRB1
71 autoimmune disease of central nervous system 9.8 IL1B HLA-DRB1
72 autoimmune disease of the nervous system 9.8 IL1B HLA-DRB1
73 visceral leishmaniasis 9.8 IL1B HLA-DRB1
74 leishmaniasis 9.8 IL1B HLA-DRB1
75 autoimmune disease of musculoskeletal system 9.7 IL1B HLA-DRB1
76 viral hepatitis 9.7 IL1B HLA-DRB1
77 bone inflammation disease 9.7 IL1B HLA-DRB1
78 acquired immunodeficiency syndrome 9.7 IL1B APOE
79 inherited metabolic disorder 9.7 IL1B APOE
80 relapsing-remitting multiple sclerosis 9.6 IL1B HLA-DRB1 APOE
81 multiple sclerosis 9.6 IL1B HLA-DRB1 APOE
82 neuritis 9.6 IL1B HLA-DRB1 APOE
83 narcolepsy 9.6 IL1B HLA-DRB1 APOE
84 sarcoidosis 1 9.6 IL1B HLA-DRB1
85 speech and communication disorders 9.5 IL1B APOE

Graphical network of the top 20 diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:



Diseases related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Symptoms & Phenotypes for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Drugs & Therapeutics for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Search Clinical Trials , NIH Clinical Center for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Genetic Tests for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Anatomical Context for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

MalaCards organs/tissues related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

40
Temporal Lobe, Amygdala, Cortex, Brain, Bone Marrow, Cerebellum, Cingulate Cortex

Publications for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Articles related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis:

(showing 248, show less)
# Title Authors PMID Year
1
AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone. 61
33404979 2021
2
The Thalamic and Intracortical Inhibitory Function of Somatosensory System Is Unchanged in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis. 61
33675312 2021
3
Quality of life long after temporal lobe epilepsy surgery. 61
33751549 2021
4
Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease. 61
33722437 2021
5
VIPergic neuroprotection in epileptogenesis: challenges and opportunities. 61
33338622 2021
6
Ictal fear is associated with anxiety symptoms and interictal dysphoric disorder in drug-resistant mesial temporal lobe epilepsy. 61
33348195 2021
7
Electrical Stimulation of Subiculum for the Treatment of Refractory Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A 2-Year Follow-Up Study. 61
33113540 2021
8
Proteomic profile differentiating between mesial temporal lobe epilepsy with and without hippocampal sclerosis. 61
33197783 2020
9
How predictable is cognitive performance in Brazilian patients with pharmacoresistant mesial temporal lobe epilepsy? 61
33181899 2020
10
Role of Altered Expression, Activity and Sub-cellular Distribution of Various Histone Deacetylases (HDACs) in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
33258018 2020
11
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes. 61
32731050 2020
12
Neuropsychological findings related to the presence of pre-surgical comorbid depression in Latin-American patients with mesial temporal lobe epilepsy and hippocampal sclerosis. 61
32771825 2020
13
Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS). 61
32543742 2020
14
Voxel-based morphometry analysis and machine learning based classification in pediatric mesial temporal lobe epilepsy with hippocampal sclerosis. 61
31250266 2020
15
Altered coupling between resting-state glucose metabolism and functional activity in epilepsy. 61
32860354 2020
16
Expression of circulating microRNAs as predictors of diagnosis and surgical outcome in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
32682279 2020
17
α7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 61
32770411 2020
18
The Relationship Between Clinico-Pathological Properties and p-Glycoprotein Expression in Hippocampal Sclerosis Among Patients with Mesial Temporal Lobe Epilepsy Who Undergo Selective Amygdalohippocampectomy Operation. 61
32952422 2020
19
Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. 61
32111564 2020
20
Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances. 61
32157145 2020
21
Untargeted lipidomic analysis of human hippocampus for temporal lobe epilepsy with hippocampal sclerosis. 61
32105993 2020
22
Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety. 61
29880883 2020
23
Social impairment and stigma in genetic generalized epilepsies. 61
31931462 2020
24
On brain atlas choice and automatic segmentation methods: a comparison of MAPER & FreeSurfer using three atlas databases. 61
32071355 2020
25
Abnormalities of Cortical Thickness in Pediatric Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
33135613 2020
26
Differential Glial Activation in Early Epileptogenesis-Insights From Cell-Specific Analysis of DNA Methylation and Gene Expression in the Contralateral Hippocampus. 61
33312155 2020
27
"Benign" temporal lobe epilepsy with hippocampal sclerosis: A forgotten entity? 61
33313502 2020
28
Plasma Exosomal MiRNAs Expression Profile in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis: Case-Control Study and Analysis of Potential Functions. 61
33240042 2020
29
VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy. 61
32595454 2020
30
Epilepsy miRNA Profile Depends on the Age of Onset in Humans and Rats. 61
33041753 2020
31
Expression of MicroRNAs miR-145, miR-181c, miR-199a and miR-1183 in the Blood and Hippocampus of Patients with Mesial Temporal Lobe Epilepsy. 61
31368064 2019
32
Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression. 61
31208877 2019
33
Investigation of Generalized EEG Paroxysms Accompanying Focal Epilepsies. 61
31248273 2019
34
Optimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis. 61
31521052 2019
35
Magnetic resonance fingerprinting of temporal lobe white matter in mesial temporal lobe epilepsy. 61
31359636 2019
36
Revisiting personality in epilepsy: Differentiation of personality in two epilepsies starting in adolescence. 61
31195327 2019
37
Transcriptomic and genetic analyses reveal potential causal drivers for intractable partial epilepsy. 61
30932156 2019
38
Follow-up of patients with epilepsy harboring antiglycine receptor antibodies. 61
30641251 2019
39
Hospital Anxiety and Depression Scale-Anxiety subscale (HADS-A) and The State-Trait Anxiety Inventory (STAI) accuracy for anxiety disorders detection in drug-resistant mesial temporal lobe epilepsy patients. 61
30599368 2019
40
The Dilemma of the Chicken or the Egg-What Appears First in TLE-Seizures or Morphometric Changes in the Temporal Lobe? 61
30955428 2019
41
Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study. 61
30324623 2019
42
Reduced Interhemispheric White Matter Asymmetries in Medial Temporal Lobe Epilepsy With Hippocampal Sclerosis. 61
31068889 2019
43
Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients. 61
30587513 2019
44
Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy. 61
30576963 2019
45
Commentary on Nóbrega-Jr et al. "Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal antibodies". 61
30451294 2018
46
The impact of epilepsy duration in a series of patients with mesial temporal lobe epilepsy due to unilateral hippocampal sclerosis. 61
30248630 2018
47
Meta-analysis of voxel-based morphometry studies of gray matter abnormalities in patients with mesial temporal lobe epilepsy and unilateral hippocampal sclerosis. 61
29302917 2018
48
Symmetric tract-based spatial statistics of patients with left versus right mesial temporal lobe epilepsy with hippocampal sclerosis. 61
30113923 2018
49
Hippocampal activations in mesial temporal lobe epilepsy due to hippocampal sclerosis- an observational study on intramural encoding-delayed recall paradigms using task-based memory fMRI. 61
29859335 2018
50
Is self-report sleepiness associated with cognitive performance in temporal lobe epilepsy? 61
30365619 2018
51
New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis. 61
29476662 2018
52
Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal autoantibodies. 61
30146688 2018
53
Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
29904720 2018
54
Morphometric MRI features and surgical outcome in patients with epilepsy related to hippocampal sclerosis and low intellectual quotient. 61
29625365 2018
55
Immunogenetic predisposing factors for mesial temporal lobe epilepsy with hippocampal sclerosis. 61
28675059 2018
56
Volumetric Changes in Hippocampal Subregions and Memory Performance in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
29094314 2018
57
Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis. 61
29651571 2018
58
Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
29247965 2018
59
Parahippocampectomy as a New Surgical Approach to Mesial Temporal Lobe Epilepsy Caused By Hippocampal Sclerosis: A Pilot Randomized Comparative Clinical Trial. 61
29229342 2018
60
Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells. 61
27688159 2018
61
Is inpatient ictal video-electroencephalographic monitoring mandatory in mesial temporal lobe epilepsy with unilateral hippocampal sclerosis? A prospective study. 61
29238960 2018
62
Verbal learning and memory outcome in selective amygdalohippocampectomy versus temporal lobe resection in patients with hippocampal sclerosis. 61
29306849 2018
63
[Clinical and pathological definition of temporal medium epilepsy subtypes with hypocampic sclerosis]. 61
29089238 2018
64
Neuropsychological functioning and brain energetics of drug resistant mesial temporal lobe epilepsy patients. 61
29040828 2017
65
Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis. 61
29321710 2017
66
Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients. 61
29153613 2017
67
Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy. 61
28795432 2017
68
Understanding the association of neurocysticercosis and mesial temporal lobe epilepsy and its impact on the surgical treatment of patients with drug-resistant epilepsy. 61
28462844 2017
69
Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
28941835 2017
70
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
28857179 2017
71
MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. 61
28815576 2017
72
Age of onset of mesial temporal lobe epilepsy with hippocampal sclerosis: the effect of apolipoprotein E and febrile seizures. 61
27875923 2017
73
Predictive factors of long-term outcomes of surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis. 61
28656696 2017
74
Predictors of meaningful improvement in quality of life after temporal lobe epilepsy surgery: A prospective study. 61
28332703 2017
75
Morphometric MRI features are associated with surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
28324681 2017
76
Importance of neuropsychological and clinical features to predict seizure control in medically treated patients with mesial temporal epilepsy and hippocampal sclerosis. 61
28242475 2017
77
Is 'burned-out hippocampus' syndrome a distinct electro-clinical variant of MTLE-HS syndrome? 61
28235654 2017
78
Hippocampal Atrophy Is Associated with Altered Hippocampus-Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
28104639 2017
79
Short-term cerebral activity alterations after surgery in patients with unilateral mesial temporal lobe epilepsy associated with hippocampal sclerosis: A longitudinal resting-state fMRI study. 61
28226275 2017
80
Metal maps of sclerotic hippocampi of patients with mesial temporal lobe epilepsy. 61
28124054 2017
81
Electrophysiological resting-state biomarker for diagnosing mesial temporal lobe epilepsy with hippocampal sclerosis. 61
28043064 2017
82
Parahippocampal Involvement in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: A Proof of Concept from Memory-Guided Saccades. 61
29163352 2017
83
Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis. 61
27926529 2017
84
Transcranial Direct Current Stimulation in Mesial Temporal Lobe Epilepsy and Hippocampal Sclerosis. 61
27693237 2017
85
Brain Infiltration of Immune Cells in CASPR2-Antibody Associated Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
28360810 2016
86
1H-MRS metabolite's ratios show temporal alternation in temporal lobe seizure: Comparison between interictal and postictal phases. 61
27838503 2016
87
Hippocampal atrophy on MRI is predictive of histopathological patterns and surgical prognosis in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
27842262 2016
88
Clinical and electrophysiological findings in mesial temporal lobe epilepsy with hippocampal sclerosis, based on the recent histopathological classifications. 61
27561188 2016
89
Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives. 61
27659220 2016
90
The effect of transcranial direct current stimulation on seizure frequency of patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
27450765 2016
91
Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis - Influence on microglial function. 61
27666871 2016
92
Evaluation of Glutamic Acid Decarboxylase Antibody Levels in Patients with Juvenile Myoclonic Epilepsy and Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis. 61
28373803 2016
93
Age at onset and seizure frequency affect white matter diffusion coefficient in patients with mesial temporal lobe epilepsy. 61
27232377 2016
94
Mesial temporal lobe epilepsy with hippocampal sclerosis as a neuroimmunological disorder. 61
27170276 2016
95
Neuronal autoantibodies in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
27151964 2016
96
Epilepsy diagnostic and treatment needs identified with a collaborative database involving tertiary centers in France. 61
27037674 2016
97
RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS. 61
27094248 2016
98
Changes in Central Auditory Processing in Patients with Mesial Temporal Lobe Epilepsy after Anterior Temporal Lobectomy with Amygdalohippocampectomy. 61
27074293 2016
99
Temporal Cortex Morphology in Mesial Temporal Lobe Epilepsy Patients and Their Asymptomatic Siblings. 61
25576532 2016
100
More Severe Extratemporal Damages in Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis Than That With Other Lesions: A Multimodality MRI Study. 61
26962820 2016
101
Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value for epilepsy surgery. 61
26321666 2016
102
Combined 18F-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
27995064 2016
103
Combined effect between two functional polymorphisms of SLC6A12 gene is associated with temporal lobe epilepsy. 61
26690518 2015
104
Gamma Knife radiosurgery for recurrent or residual seizures after anterior temporal lobectomy in mesial temporal lobe epilepsy patients with hippocampal sclerosis: long-term follow-up results of more than 4 years. 61
26162046 2015
105
Lateralizing value of semiology in medial temporal lobe epilepsy. 61
25855246 2015
106
Asymmetry in cross-hippocampal connectivity in unilateral mesial temporal lobe epilepsy. 61
26561924 2015
107
Volumetric and shape analysis of hippocampal subfields in unilateral mesial temporal lobe epilepsy with hippocampal atrophy. 61
26425829 2015
108
Neuroimaging observations linking neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis. 61
26354165 2015
109
Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy. 61
26119622 2015
110
Religiosity aspects in patients with epilepsy. 61
26133113 2015
111
Are auras a reliable clinical indicator in medial temporal lobe epilepsy with hippocampal sclerosis? 61
26073635 2015
112
Complete seizure freedom is possible in patients with MTLE-HS after surgery in spite of extratemporal electro-clinical features. 61
25986197 2015
113
Mesial temporal lobe epilepsy with hippocampal sclerosis is a network disorder with altered cortical hubs. 61
25809843 2015
114
Hippocampal antioxidative system in mesial temporal lobe epilepsy. 61
25864570 2015
115
Memory outcome following left anterior temporal lobectomy in patients with a failed Wada test. 61
25768711 2015
116
MTLE with hippocampal sclerosis in adult as a syndrome. 61
25727907 2015
117
Patterns of seizure control in patients with mesial temporal lobe epilepsy with and without hippocampus sclerosis. 61
25742574 2015
118
Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis. 61
26328621 2015
119
Neurocysticercotic Calcifications and Hippocampal Sclerosis: A Case-Control Study. 61
26132287 2015
120
Memory, executive function and language function are similarly impaired in both temporal and extra temporal refractory epilepsy-A prospective study. 61
25524845 2015
121
Comparison of temporal lobe epilepsy with hippocampal sclerosis and temporal lobe epilepsies due to other etiologies. 61
26793654 2015
122
Characteristics of mesial temporal lobe epilepsy associated with hippocampal sclerosis plus neurocysticercosis. 61
25306064 2014
123
Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance. 61
25410734 2014
124
Short-term cognitive changes after surgery in patients with unilateral mesial temporal lobe epilepsy associated with hippocampal sclerosis. 61
24908373 2014
125
Distinct functional and structural MRI abnormalities in mesial temporal lobe epilepsy with and without hippocampal sclerosis. 61
24903633 2014
126
Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
24962348 2014
127
Serial postoperative awake and sleep EEG and long-term seizure outcome after anterior temporal lobectomy for hippocampal sclerosis. 61
24721201 2014
128
Growth-associated protein 43 and progressive epilepsy in cortical dysplasia. 61
25356416 2014
129
Factors predicting the outcome following medical treatment of mesial temporal epilepsy with hippocampal sclerosis. 61
24680551 2014
130
Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy. 61
24673751 2014
131
Pattern changes of EEG oscillations and BOLD signals associated with temporal lobe epilepsy as revealed by a working memory task. 61
24766708 2014
132
Mitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis. 61
24440288 2014
133
Past and present definitions of epileptogenesis and its biomarkers. 61
24492975 2014
134
Investigation of neuronal autoantibodies in two different focal epilepsy syndromes. 61
24502404 2014
135
Prnp gene and cerebellum volume in patients with refractory mesial temporal lobe epilepsy. 61
24091711 2014
136
Spirituality aspects in patients with epilepsy. 61
24094727 2014
137
Temporal lobe epilepsy with amygdala enlargement: a morphologic and functional study. 61
22304227 2014
138
Genetic association analysis of ATP binding cassette protein family reveals a novel association of ABCB1 genetic variants with epilepsy risk, but not with drug-resistance. 61
24586633 2014
139
Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
23771402 2014
140
Usefulness of Wada test in predicting seizure outcome following anterior temporal lobectomy. 61
24120923 2013
141
Periodic epileptiform discharges in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
23787169 2013
142
GABRG2, rs211037 is associated with epilepsy susceptibility, but not with antiepileptic drug resistance and febrile seizures. 61
24061200 2013
143
Whole mitochondrial DNA variations in hippocampal surgical specimens and blood samples with high-throughput sequencing: a case of mesial temporal lobe epilepsy with hippocampal sclerosis. 61
23872536 2013
144
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. 61
24014518 2013
145
Self-reported quality of life in pharmacoresistant temporal lobe epilepsy: correlation with clinical variables and memory evaluation. 61
23906668 2013
146
A critical evaluation of the lateralizing significance of material-specific memory deficits in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
23891768 2013
147
Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
23751308 2013
148
A quadruple examination of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis: onset, propagation, later significant pattern, and termination. 61
23912569 2013
149
Differences between RNA and DNA due to RNA editing in temporal lobe epilepsy. 61
23607937 2013
150
Surgical pathology of epilepsy-associated non-neoplastic cerebral lesions: a brief introduction with special reference to hippocampal sclerosis and focal cortical dysplasia. 61
23530853 2013
151
An 18-year follow-up of seizure outcome after surgery for temporal lobe epilepsy and hippocampal sclerosis. 61
23408065 2013
152
Temporal lobe epilepsy with hippocampal sclerosis in acute lymphoblastic leukemia. 61
23776122 2013
153
Mesial temporal lobe epilepsy with hippocampal sclerosis preceded by eclampsia: a rare association. 61
24005737 2013
154
Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis. 61
23511251 2013
155
[Cognitive function related to temporal lobe epilepsy: advances in research on new cognitive function]. 61
23667120 2013
156
On the prognostic value of ictal EEG patterns in temporal lobe epilepsy surgery: a cohort study. 61
23465565 2013
157
Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy. 61
23294137 2013
158
Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy. 61
23392471 2013
159
Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patients. 61
25206700 2013
160
Interleukin-1β secretion in hippocampal sclerosis patients with mesial temporal lobe epilepsy. 61
24147214 2013
161
Morphological variations of hippocampal formation in epilepsy: image, clinical and electrophysiological data. 61
23220462 2013
162
Cognitive and surgical outcome in mesial temporal lobe epilepsy associated with hippocampal sclerosis plus neurocysticercosis: a cohort study. 61
23613762 2013
163
Altered hemispheric symmetry found in left-sided mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE/HS) but not found in right-sided MTLE/HS. 61
22925605 2013
164
Clinical phenotypes within non-surgical patients with mesial temporal lobe epilepsy caused by hippocampal sclerosis based on response to antiepileptic drugs. 61
23041032 2013
165
Preoperative depressive symptoms are not predictors of postoperative seizure control in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. 61
23247268 2013
166
Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy. 61
23626743 2013
167
Sexual desire and satisfaction after resective surgery in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
23103313 2012
168
Predictors of quality of life in patients with refractory mesial temporal lobe epilepsy. 61
23032134 2012
169
Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis. 61
22578703 2012
170
On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis: coincidence or a pathogenic relationship? 61
23265552 2012
171
Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy. 61
22614924 2012
172
Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines. 61
22935090 2012
173
Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
22510097 2012
174
Antiepileptic drugs management and long-term seizure outcome in post surgical mesial temporal lobe epilepsy with hippocampal sclerosis. 61
22336897 2012
175
The role of voxel-based morphometry in the detection of cortical dysplasia within the temporal pole in patients with intractable mesial temporal lobe epilepsy. 61
22510082 2012
176
Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis. 61
22497612 2012
177
Auras in temporal lobe epilepsy with hippocampal sclerosis: relation to seizure focus laterality and post surgical outcome. 61
22520586 2012
178
A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis. 61
22197033 2012
179
Atypical language lateralisation associated with right fronto-temporal grey matter increases--a combined fMRI and VBM study in left-sided mesial temporal lobe epilepsy patients. 61
21839176 2012
180
Mesial temporal lobe epilepsy with hippocampal sclerosis in two pairs of identical twins. 61
22794520 2012
181
Genomic microdeletions associated with epilepsy: not a contraindication to resective surgery. 61
21635232 2011
182
Hippocampal sclerosis and ipsilateral headache among mesial temporal lobe epilepsy patients. 61
21439855 2011
183
Headache among mesial temporal lobe epilepsy patients: a case-control study. 61
21549393 2011
184
Corpora amylacea deposition in the hippocampus of patients with mesial temporal lobe epilepsy: A new role for an old gene? 61
21747587 2011
185
Diffusion tensor imaging analysis with tract-based spatial statistics of the white matter abnormalities after epilepsy surgery. 61
21377331 2011
186
Prognostic importance of serial postoperative EEGs after anterior temporal lobectomy. 61
21624992 2011
187
In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis. 61
21303859 2011
188
Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. 61
21185343 2011
189
The role of underlying structural cause for epilepsy classification: clinical features and prognosis in mesial temporal lobe epilepsy caused by hippocampal sclerosis versus cavernoma. 61
21426322 2011
190
Is Temporal Lobe Epilepsy with childhood febrile seizures a distinctive entity? A comparative study. 61
21167748 2011
191
Mesial temporal lobe epilepsy with hippocampal sclerosis: study of 42 children. 61
21112221 2011
192
Utility of ictal single photon emission computed tomography in mesial temporal lobe epilepsy with hippocampal atrophy: a randomized trial. 61
21135733 2011
193
Analysis of reoperation in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
21099715 2011
194
Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
22937234 2011
195
How frequent is the association of neurocysticercosis and mesial temporal lobe epilepsy with hippocampal sclerosis? 61
20977472 2010
196
Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: uncontrolled inflammation drives disease progression? 61
20663517 2010
197
Temporal lobe epilepsy and matrix metalloproteinase 9: a tempting relation but negative genetic association. 61
20605480 2010
198
Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis. 61
20547107 2010
199
An optimized voxel-based morphometric study of gray matter changes in patients with left-sided and right-sided mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE/HS). 61
19817822 2010
200
Innate but not adaptive immune responses contribute to behavioral seizures following viral infection. 61
19845729 2010
201
Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. 61
19864112 2010
202
Hippocampal volume assessment in temporal lobe epilepsy: How good is automated segmentation? 61
19682030 2009
203
Extent of initial injury determines language lateralization in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 61
19744113 2009
204
Low resolution electromagnetic tomography analysis of ictal EEG patterns in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
19748825 2009
205
Spatiotemporospectral characteristics of scalp ictal EEG in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
19563787 2009
206
Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: a postmortem study. 61
19710404 2009
207
Serotonin transporter gene variation and refractory mesial temporal epilepsy with hippocampal sclerosis. 61
19375285 2009
208
ApoE epsilon4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. 61
19375284 2009
209
Prognosis of patients with mesial temporal lobe epilepsy due to hippocampal sclerosis. 61
19345070 2009
210
Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse. 61
19412934 2009
211
Correlation study of optimized voxel-based morphometry and (1)H MRS in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. 61
18609565 2009
212
Do psychiatric comorbidities predict postoperative seizure outcome in temporal lobe epilepsy surgery? 61
19186216 2009
213
Phenotypic characteristics of temporal lobe epilepsy: the impact of hippocampal sclerosis. 61
19566491 2009
214
Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the "latent period" and other concepts. 61
19087122 2008
215
Predictive factors for postoperative outcome in temporal lobe epilepsy according to two different classifications. 61
18403220 2008
216
GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence. 61
18255321 2008
217
Impaired facial emotion recognition in patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS): Side and age at onset matters. 61
18468867 2008
218
[Changes in spontaneous epileptic activity after selective intrahippocampal transection in a model of chronic mesial temporal lobe epilepsy]. 61
18417168 2008
219
Surgical outcome of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis. 61
18205819 2008
220
Long-term seizure outcome after mesial temporal lobe epilepsy surgery: corticalamygdalohippocampectomy versus selective amygdalohippocampectomy. 61
18312099 2008
221
Magnetic resonance spectroscopy of the thalamus in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. 61
18319202 2007
222
Clinical characteristics in patients with hippocampal sclerosis with or without cortical dysplasia. 61
18319204 2007
223
Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
17088374 2007
224
Corpora amylacea in mesial temporal lobe epilepsy: clinico-pathological correlations. 61
17336043 2007
225
Cognitive changes after unilateral cortico-amygdalohippocampectomy unilateral selective-amygdalohippocampectomy mesial temporal lobe epilepsy. 61
17935023 2007
226
Memory guided saccades in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
16978920 2006
227
Foramen ovale electrodes can identify a focal seizure onset when surface EEG fails in mesial temporal lobe epilepsy. 61
16922874 2006
228
Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis. 61
16762567 2006
229
Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis. 61
16546408 2006
230
Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171. 61
16580884 2006
231
The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis. 61
16383112 2006
232
Seizure and memory outcome following temporal lobe surgery: selective compared with nonselective approaches for hippocampal sclerosis. 61
16509149 2006
233
Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy. 61
16217065 2005
234
Cognitive performance of patients with mesial temporal lobe epilepsy and incidental calcified neurocysticercosis. 61
16024883 2005
235
Association between APOE polymorphisms and mesial temporal lobe epilepsy with hippocampal sclerosis. 61
15679697 2005
236
Interictal SPECT in patients with mesial temporal lobe epilepsy and psychosis: a case-control study. 61
15708303 2005
237
Antiepileptic drug treatment in seizure-free mesial temporal lobe epilepsy patients with hippocampal sclerosis following selective amygdalohippocampectomy. 61
15519912 2004
238
Survival analysis of the surgical outcome of temporal lobe epilepsy due to hippocampal sclerosis. 61
15509239 2004
239
Memory in patients with drug-responsive mesial temporal lobe epilepsy and hippocampal sclerosis. 61
15509240 2004
240
High capacity and low cost detection of prion protein gene variant alleles by denaturing HPLC. 61
15488240 2004
241
Qualitative and quantitative imaging of the hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
15324854 2004
242
ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis. 61
15144438 2004
243
Correlation between 1H MRS and memory before and after surgery in mesial temporal lobe epilepsy with hippocampal sclerosis. 61
15144428 2004
244
Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant. 61
14610121 2003
245
Contralateral medial temporal lobe damage in right but not left temporal lobe epilepsy: a (1)H magnetic resonance spectroscopy study. 61
12933926 2003
246
An association between mesial temporal lobe epilepsy with hippocampal sclerosis and human leukocyte antigens. 61
11906507 2002
247
GABA and L-glutamic acid release in en bloc resection slices of human hippocampus: an in vitro microdialysis study. 61
11808852 2001
248
Surgical outcome of epilepsy patients evaluated with a noninvasive protocol. 61
10963477 2000

Variations for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Expression for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Search GEO for disease gene expression data for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis.

Pathways for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Pathways related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

(showing 5, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.37 IL1B HLA-DRB1
2 11.25 IL1B HLA-DRB1
3 11.12 IL1B HLA-DRB1
4 10.61 IL1B APOE
5 10.09 IL1B HLA-DRB1

GO Terms for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Cellular components related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 clathrin-coated endocytic vesicle membrane GO:0030669 8.62 HLA-DRB1 APOE

Biological processes related to Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.33 IL1B HLA-DRB1 APOE
2 negative regulation of MAP kinase activity GO:0043407 8.96 IL1B APOE
3 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 IL1B APOE

Sources for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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