MCID: MTB004
MIFTS: 49

Metabolic Acidosis

Categories: Metabolic diseases

Aliases & Classifications for Metabolic Acidosis

MalaCards integrated aliases for Metabolic Acidosis:

Name: Metabolic Acidosis 12 76 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050758
UMLS 73 C0220981

Summaries for Metabolic Acidosis

Disease Ontology : 12 An acquired metabolic disease that characterized by excessive production of acid.

MalaCards based summary : Metabolic Acidosis is related to renal tubular acidosis, distal and renal tubular acidosis. An important gene associated with Metabolic Acidosis is HMGCL (3-Hydroxy-3-Methylglutaryl-CoA Lyase), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Metformin and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or... more...

Related Diseases for Metabolic Acidosis

Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 renal tubular acidosis, distal 32.6 ATP6V0A4 ATP6V1B1 SLC4A1
2 renal tubular acidosis 31.9 ATP6V0A4 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A3
3 renal tubular acidosis, distal, autosomal dominant 31.9 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
4 renal tubular acidosis, distal, autosomal recessive 31.7 ATP6V0A4 ATP6V1B1 SLC4A1
5 medullary sponge kidney 29.8 ATP6V0A4 ATP6V1B1
6 propionic acidemia 29.4 HLCS HMGCL MLYCD
7 ovarian dysgenesis, hypergonadotropic, with short stature and recurrent metabolic acidosis 12.2
8 glutathione synthetase deficiency 11.6
9 fructose-1,6-bisphosphatase deficiency 11.6
10 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.5
11 lactic acidosis 11.4
12 d-glyceric aciduria 11.4
13 pseudohypoaldosteronism, type iia 11.3
14 leigh syndrome, french canadian type 11.2
15 multiple acyl-coa dehydrogenase deficiency 11.2
16 malonyl-coa decarboxylase deficiency 11.2
17 renal tubular acidosis, distal, with progressive nerve deafness 11.2
18 hawkinsinuria 11.1
19 malignant hyperthermia 1 11.1
20 3-methylglutaconic aciduria, type i 11.1
21 fumarase deficiency 11.1
22 mitochondrial trifunctional protein deficiency 11.1
23 mitochondrial complex i deficiency due to acad9 deficiency 11.1
24 renal tubular acidosis, distal, with hemolytic anemia 11.1
25 pseudohypoaldosteronism, type iid 11.1
26 pseudohypoaldosteronism, type iie 11.1
27 carbonic anhydrase va deficiency, hyperammonemia due to 11.1
28 alpha-ketoglutarate dehydrogenase deficiency 11.0
29 arthrogryposis, renal dysfunction, and cholestasis 1 11.0
30 cranioectodermal dysplasia 1 11.0
31 hydroxykynureninuria 11.0
32 isovaleric acidemia 11.0
33 methylmalonyl-coa epimerase deficiency 11.0
34 mitochondrial myopathy with lactic acidosis 11.0
35 holocarboxylase synthetase deficiency 11.0
36 mitochondrial dna depletion syndrome 6 11.0
37 pseudohypoaldosteronism, type i, autosomal recessive 11.0
38 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.0
39 hsd10 mitochondrial disease 11.0
40 carnitine palmitoyltransferase ii deficiency, infantile 11.0
41 nephronophthisis 2 11.0
42 combined oxidative phosphorylation deficiency 2 11.0
43 combined oxidative phosphorylation deficiency 3 11.0
44 combined oxidative phosphorylation deficiency 5 11.0
45 pseudohypoaldosteronism, type iib 11.0
46 pseudohypoaldosteronism, type iic 11.0
47 mitochondrial pyruvate carrier deficiency 11.0
48 riboflavin deficiency 11.0
49 sudden cardiac failure, infantile 11.0
50 2-methyl-3-hydroxybutyric aciduria 11.0

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to Metabolic Acidosis

Symptoms & Phenotypes for Metabolic Acidosis

GenomeRNAi Phenotypes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.03 WNK4
2 Decreased viability GR00221-A-2 10.03 WNK4
3 Decreased viability GR00221-A-4 10.03 WNK4
4 Decreased viability GR00381-A-1 10.03 MLYCD
5 Decreased viability GR00402-S-2 10.03 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 BGLAP
6 no effect GR00402-S-1 9.62 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 BGLAP

MGI Mouse Phenotypes related to Metabolic Acidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2
2 renal/urinary system MP:0005367 9.36 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2

Drugs & Therapeutics for Metabolic Acidosis

Drugs for Metabolic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 421)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3
Parecoxib Approved Phase 4 198470-84-7
4
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
5
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
6
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
7
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
8
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
9
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
10
Dobutamine Approved Phase 4,Phase 2,Not Applicable 34368-04-2 36811
11
Norepinephrine Approved Phase 4,Phase 2,Not Applicable 51-41-2 439260
12
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
13 tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14
Spironolactone Approved Phase 4,Phase 2 52-01-7, 1952-01-7 5833
15
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
16
Phenylephrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 59-42-7 6041
17
Oxymetazoline Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 1491-59-4 4636
18
Ephedrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 299-42-3 9294
19
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 90-82-4 7028
20
Fenoldopam Approved Phase 4 67227-57-0, 67227-56-9 3341
21
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
22
Insulin Glargine Approved Phase 4,Not Applicable 160337-95-1
23
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6
24
Insulin glulisine Approved Phase 4 207748-29-6
25
Remifentanil Approved Phase 4 132875-61-7 60815
26
Meperidine Approved Phase 4 57-42-1 4058
27
Empagliflozin Approved Phase 4 864070-44-0
28
Nitric Oxide Approved Phase 4,Phase 1,Phase 2,Not Applicable 10102-43-9 145068
29
Insulin Aspart Approved Phase 4,Not Applicable 116094-23-6 16132418
30
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
31
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
32
Hydralazine Approved Phase 4 86-54-4 3637
33
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
34
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
35
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
36
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
37
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
38
Amphotericin B Approved, Investigational Phase 4 1397-89-3 5280965 14956
39
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
40
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-43-8, 70-16-6 1130
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
42
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
43
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 83-88-5 493570
44
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
45
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
46
Adefovir Investigational Phase 4 106941-25-7
47 Simendan Investigational Phase 4 131741-08-7
48 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Vitamin B9 Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 439)
# Name Status NCT ID Phase Drugs
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
2 Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation Unknown status NCT00885404 Phase 4 Lower chloride fluids (Hartmann's solution and Plasmalyte®)
3 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
4 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
5 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
6 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
7 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
8 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
9 Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program Unknown status NCT02663960 Phase 4
10 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
11 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI) Completed NCT01481740 Phase 4 Phenylephrine bolus;phenylephrine infusion
12 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
13 Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients Completed NCT01356433 Phase 4 oral vitamin C;oral vitamin C
14 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
15 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
16 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
17 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
18 Effect of Prime Solution on Fluid Balance After Open Heart Surgery Completed NCT00797589 Phase 4 HES;Ringer lactate
19 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
20 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
21 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
22 Arterial pH and Total Body Nitrogen Balances in APD Completed NCT00586131 Phase 4 ammonium chloride or sodium citrate/citric acid;Sodium citrate/citratic acid
23 Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA) Completed NCT00590044 Phase 4 insulin glargine+ glulisine;NPH + Regular insulin
24 Optiflow® to Prevent Post-Extubation Hypoxemia afteR Abdominal Surgery (the OPERA Trial) Completed NCT01887015 Phase 4
25 Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment Completed NCT01099618 Phase 4 metformin;placebo;Sitagliptin
26 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
27 The Effects of Levosimendan During Mitral Valve Surgery Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
28 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study Completed NCT01424150 Phase 4
29 A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour Completed NCT02179294 Phase 4 Pethidine;Remifentanil
30 Double Blinded Randomized Control Trial of Types of IVF in Children With DKA Recruiting NCT03066440 Phase 4 Normal saline;Lactated Ringers
31 Preserve-Transplant Study Recruiting NCT03102996 Phase 4 Nephrotrans
32 Alkalinization by Urologists & Nephrologists Recruiting NCT03035812 Phase 4 Alkali
33 Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Recruiting NCT01513655 Phase 4
34 Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluid During Renal Transplantation Recruiting NCT03115060 Phase 4 intravenous fluid administration WITH NORMAL SALINE, PLASMALYTE A, OR RINGER LACTATE
35 Studies of Empagliflozin and Its Cardiovascular, Renal and Metabolic Effects Recruiting NCT03485092 Phase 4 Empagliflozin 10 MG;Placebo Oral Tablet
36 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Recruiting NCT03549923 Phase 4 Esmolol;Standard care
37 DANHEART (H-HeFT and Met-HeFT) Recruiting NCT03514108 Phase 4 Hydralazine Isosorbide Dinitrate;Placebo Oral Tablet;Metformin Hydrochloride;Placebo Oral Tablet
38 Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy Recruiting NCT03112538 Phase 4 Multiple daily injections of insulin
39 Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Recruiting NCT03107208 Phase 4 Glargine
40 Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery Enrolling by invitation NCT02527811 Phase 4 Ulinastatin
41 Changes of Gas Values in Cord Blood Versus Time and Temperature Not yet recruiting NCT02785367 Phase 4
42 Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes. Not yet recruiting NCT03640221 Phase 4 Ertugliflozin;Hydrochlorothiazide 12.5mg
43 Metformin Use to Improve Pregnancy Outcome in Women With Type 1 Diabetes. Not yet recruiting NCT03765359 Phase 4 metforminhydrochloride;Placebo Oral Tablet
44 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
45 Intravenous (IV) Solutions for Dehydration in Children With Gastroenteritis Terminated NCT01234883 Phase 4 multiple electrolyte solution;saline
46 Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support Terminated NCT02414555 Phase 4 vasopressor;fluid bolus;Normal Saline;Elo-Mel Isoton (balanced acetat-based infusate)
47 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
48 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
49 Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD) Unknown status NCT01640119 Phase 3
50 Fluid Resuscitation in Acute Pancreatitis Unknown status NCT02709044 Phase 2, Phase 3 Ringer lactate

Search NIH Clinical Center for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

Genetic tests related to Metabolic Acidosis:

# Genetic test Affiliating Genes
1 Metabolic Acidosis 29

Anatomical Context for Metabolic Acidosis

MalaCards organs/tissues related to Metabolic Acidosis:

41
Kidney, Bone, Heart, Liver, Skin, Brain, Lung

Publications for Metabolic Acidosis

Articles related to Metabolic Acidosis:

(show top 50) (show all 1066)
# Title Authors Year
1
Recurrent Metabolic Acidosis during High-dose Midazolam Therapy for Refractory Status Epilepticus. ( 29531455 )
2018
2
Metabolic acidosis in short bowel syndrome: think D-lactic acid acidosis. ( 29769189 )
2018
3
NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. ( 29618784 )
2018
4
Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function. ( 29333622 )
2018
5
Fresh red blood cells transfusion protects against aluminum phosphide-induced metabolic acidosis and mortality in rats. ( 29590163 )
2018
6
In silico identification of genes involved in chronic metabolic acidosis. ( 29138116 )
2018
7
Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease - Position Statement of the Working Group of the Polish Society of Nephrology. ( 29895022 )
2018
8
New Frontiers in Treating Uremic Metabolic Acidosis. ( 29102960 )
2018
9
Severe metabolic acidosis after out-of-hospital cardiac arrest: risk factors and association with outcome. ( 29740777 )
2018
10
Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis. ( 29488080 )
2018
11
Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )
2018
12
Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. ( 29915215 )
2018
13
Acute and chronic effects of metabolic acidosis on renal function and structure. ( 29700802 )
2018
14
Sodium bicarbonate on severe metabolic acidosis during prolonged cardiopulmonary resuscitation: a double-blind, randomized, placebo-controlled pilot study. ( 29850134 )
2018
15
Retinal pH and Acid Regulation During Metabolic Acidosis. ( 29641914 )
2018
16
Pseudohypoaldosteronism Type II: A Young Girl Presented with Hypertension, Hyperkalemia and Metabolic Acidosis. ( 29482694 )
2018
17
The problem of using standardised base excess as a measure of metabolic acidosis. ( 29430996 )
2018
18
Identifying newborns with umbilical cord blood metabolic acidosis by intrapartum cardiotography combined with fetal ECG ST analysis (STAN): comparison of the new and old FIGO systems to classify cardiotocograms. ( 29945485 )
2018
19
Zebrafish as a Model System for Investigating the Compensatory Regulation of Ionic Balance during Metabolic Acidosis. ( 29621145 )
2018
20
Hemodialysis during cardiopulmonary resuscitation in patients with severe metabolic acidosis. ( 29976124 )
2018
21
Impact of the hyperchloremic component of metabolic acidosis on the patient's hydration status and the treatment of diabetic ketoacidosis. ( 29756707 )
2018
22
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease. ( 29677110 )
2018
23
FHR patterns that become significant in connection with ST waveform changes and metabolic acidosis at birth. ( 29621906 )
2018
24
Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD. ( 29030467 )
2018
25
Metabolic acidosis as Food Protein Induced Enterocolitis Syndrome (FPIES) onset in a newborn. ( 29747671 )
2018
26
Threshold of Metabolic Acidosis Associated with Newborn Cerebral Palsy: Medical Legal Implications. ( 30529344 )
2018
27
The Case | Severe hypokalemia and metabolic acidosis. ( 29680030 )
2018
28
Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review. ( 30104478 )
2018
29
Oral alkali therapy and the management of metabolic acidosis of chronic kidney disease: A narrative literature review. ( 30324086 )
2018
30
Gamma-hydroxybutyrate (GHB), an unusual cause of high anion gap metabolic acidosis. ( 28460656 )
2018
31
Ethylene glycol intoxication presenting with high anion gap metabolic acidosis, acute kidney injury and elevated lactate. ( 29473303 )
2018
32
Critically ill neonates displayed stable vital parameters and reduced metabolic acidosis during neonatal emergency airborne transport in Sweden. ( 29480945 )
2018
33
NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis. ( 29483156 )
2018
34
Mechanism of Hyperkalemia-Induced Metabolic Acidosis. ( 29483157 )
2018
35
Metabolic acidosis and the role of unmeasured anions in critical illness and injury. ( 29506851 )
2018
36
Corrigendum to "Metabolic Acidosis and Strong Ion Gap in Critically Ill Patients with Acute Kidney Injury". ( 30035124 )
2018
37
Correction of metabolic acidosis improves muscle mass and renal function in chronic kidney disease stages 3 and 4: a randomized controlled trial. ( 30053298 )
2018
38
Early Post-operative Hemodynamic Perturbation Associated with Topiramate-induced Metabolic Acidosis: A Case Report. ( 30090142 )
2018
39
Successful treatment of life-threatening severe metabolic acidosis by continuous veno-venous hemodialysis in a child with diabetic ketoacidosis. ( 30130252 )
2018
40
Lactate Gap: A Diagnostic Support in Severe Metabolic Acidosis of Unknown Origin. ( 30140287 )
2018
41
Metabolic acidosis after sodium thiosulfate infusion and the role of hydrogen sulfide. ( 30147912 )
2018
42
Starvation ketoacidosis in pregnancy presenting as euglycaemic, high anion gap metabolic acidosis: A case report highlighting the significance of early recognition and prompt intervention. ( 30182878 )
2018
43
Metabolic acidosis in kidney transplant recipients. ( 30207550 )
2018
44
Metabolic Acidosis in Postsurgical Patient on Canagliflozin and Metformin: A Case Report. ( 30234515 )
2018
45
Metabolic Acidosis and Cardiovascular Disease Risk in CKD. ( 30237218 )
2018
46
Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. ( 30237219 )
2018
47
What is known about deferasirox chelation therapy in pediatric HSCT recipients: two case reports of metabolic acidosis. ( 30237719 )
2018
48
Effectiveness of sodium bicarbonate infusion on mortality in septic patients with metabolic acidosis. ( 30255318 )
2018
49
Young man with severe metabolic acidosis after transformer oil ingestion: a case report. ( 30301468 )
2018
50
Metabolic acidosis during general anaesthesia: presumed systemic toxicity caused by topical dorzolamide in a dog. ( 30301664 )
2018

Variations for Metabolic Acidosis

Expression for Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for Metabolic Acidosis

Pathways related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 AKR1A1 ALB ATP6V0A4 ATP6V1B1 CA2 FBP1
2
Show member pathways
13.04 ALB AQP2 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4
3 12.22 AQP2 CA2 FBP1 SLC4A4
4
Show member pathways
12.15 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
5 11.53 CA2 SLC4A4 SLC9A1
6 11.46 GSS HMGCL OGDH
7 11.31 CA2 SLC4A4 SLC9A1 SLC9A3
8 10.29 CA2 GLS2 SLC4A4 SLC9A3

GO Terms for Metabolic Acidosis

Cellular components related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2
2 apical plasma membrane GO:0016324 9.63 AKR1A1 AQP2 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
3 mitochondrial matrix GO:0005759 9.62 GLS2 HMGCL MLYCD OGDH
4 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.26 ATP6V0A4 ATP6V1B1
5 basolateral plasma membrane GO:0016323 9.1 AQP2 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A1

Biological processes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.7 SLC4A4 SLC9A1 SLC9A3
2 ion transport GO:0006811 9.7 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4 SLC9A1 SLC9A3
3 ossification GO:0001503 9.65 ATP6V0A4 ATP6V1B1 BGLAP
4 proton transmembrane transport GO:1902600 9.62 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
5 bicarbonate transport GO:0015701 9.61 CA2 SLC4A1 SLC4A4
6 excretion GO:0007588 9.54 AQP2 ATP6V0A4 ATP6V1B1
7 anion transport GO:0006820 9.51 SLC4A1 SLC4A4
8 sodium ion import across plasma membrane GO:0098719 9.49 SLC9A1 SLC9A3
9 ion homeostasis GO:0050801 9.46 KLHL3 WNK4
10 renal sodium ion absorption GO:0070294 9.4 KLHL3 WNK4
11 distal tubule morphogenesis GO:0072156 9.26 KLHL3 WNK4
12 regulation of pH GO:0006885 9.26 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
13 regulation of intracellular pH GO:0051453 9.02 CA2 SLC4A1 SLC4A4 SLC9A1 SLC9A3

Molecular functions related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 solute:proton antiporter activity GO:0015299 9.32 SLC9A1 SLC9A3
2 anion transmembrane transporter activity GO:0008509 9.26 SLC4A1 SLC4A4
3 inorganic anion exchanger activity GO:0005452 9.16 SLC4A1 SLC4A4
4 sodium:proton antiporter activity GO:0015385 8.96 SLC9A1 SLC9A3
5 potassium:proton antiporter activity GO:0015386 8.62 SLC9A1 SLC9A3

Sources for Metabolic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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