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MCID: MTB004
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Metabolic Acidosis

Categories: Metabolic diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Metabolic Acidosis

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MalaCards integrated aliases for Metabolic Acidosis:

Name: Metabolic Acidosis 12 75 29 55 15 72

Classifications:

MalaCards categories:
Global: Metabolic diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050758
UMLS 72 C0220981
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Summaries for Metabolic Acidosis

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Disease Ontology : 12 An acquired metabolic disease that characterized by excessive production of acid.

MalaCards based summary : Metabolic Acidosis is related to renal tubular acidosis, distal, autosomal recessive and renal tubular acidosis, distal, autosomal dominant. An important gene associated with Metabolic Acidosis is ATP6V1B1 (ATPase H+ Transporting V1 Subunit B1), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Insulin glulisine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and bone, and related phenotypes are no effect and Resistant to vaccinia virus (VACV-A4L) infection

Wikipedia : 75 Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or... more...

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Related Diseases for Metabolic Acidosis

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Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 399)
# Related Disease Score Top Affiliating Genes
1 renal tubular acidosis, distal, autosomal recessive 32.5 SLC4A1 ATP6V1B1 ATP6V0A4
2 renal tubular acidosis, distal, autosomal dominant 32.4 SLC4A1 CA2 ATP6V1B1 ATP6V0A4
3 renal tubular acidosis 31.1 SLC9A3 SLC4A4 SLC4A1 SCNN1G CA2 ATP6V1B1
4 medullary sponge kidney 30.3 ATP6V1B1 ATP6V0A4
5 autosomal recessive disease 30.1 MLYCD HMGCL ATP6V1B1 ATP6V0A4
6 nephrocalcinosis 29.8 SLC4A1 CA2 ATP6V1B1 ATP6V0A4 ALB
7 pseudohypoaldosteronism 29.6 WNK4 SCNN1G KLHL3
8 esophageal varix 29.6 SLC4A4 ALB
9 propionic acidemia 29.2 MLYCD HMGCL HLCS
10 ovarian dysgenesis, hypergonadotropic, with short stature and recurrent metabolic acidosis 12.5
11 glutathione synthetase deficiency 11.8
12 distal renal tubular acidosis 11.8
13 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.8
14 fructose-1,6-bisphosphatase deficiency 11.7
15 lactic acidosis 11.7
16 multiple acyl-coa dehydrogenase deficiency 11.7
17 carbonic anhydrase va deficiency, hyperammonemia due to 11.6
18 hawkinsinuria 11.6
19 d-glyceric aciduria 11.6
20 pseudohypoaldosteronism, type iie 11.5
21 hypoaldosteronism 11.5
22 renal tubular acidosis, proximal 11.4
23 lowe oculocerebrorenal syndrome 11.4
24 renal tubular acidosis, distal, with progressive nerve deafness 11.4
25 leigh syndrome, french canadian type 11.3
26 malonyl-coa decarboxylase deficiency 11.3
27 3-methylglutaconic aciduria, type i 11.3
28 pseudohypoaldosteronism, type i, autosomal recessive 11.3
29 fumarase deficiency 11.3
30 mitochondrial trifunctional protein deficiency 11.3
31 slc4a1-associated distal renal tubular acidosis 11.3
32 malignant hyperthermia 1 11.3
33 holocarboxylase synthetase deficiency 11.3
34 mitochondrial dna depletion syndrome 6 11.3
35 mitochondrial complex i deficiency, nuclear type 20 11.3
36 renal tubular acidosis, distal, with hemolytic anemia 11.3
37 pseudohypoaldosteronism, type iid 11.3
38 carbonic anhydrase va deficiency 11.3
39 corticosterone methyloxidase deficiency 11.3
40 pseudohypoaldosteronism, type iia 11.1
41 arthrogryposis, renal dysfunction, and cholestasis 1 11.1
42 cranioectodermal dysplasia 1 11.1
43 hydroxykynureninuria 11.1
44 isovaleric acidemia 11.1
45 methylmalonyl-coa epimerase deficiency 11.1
46 mitochondrial myopathy with lactic acidosis 11.1
47 pyruvate carboxylase deficiency 11.1
48 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.1
49 hsd10 mitochondrial disease 11.1
50 carnitine palmitoyltransferase ii deficiency, infantile 11.1

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to Metabolic Acidosis
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Symptoms & Phenotypes for Metabolic Acidosis

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GenomeRNAi Phenotypes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.26 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 BGLAP
2 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 9.17 ATP6V0A4 BGLAP GLS2 MLYCD SCNN1G SLC4A4

MGI Mouse Phenotypes related to Metabolic Acidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.83 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2
2 renal/urinary system MP:0005367 9.4 AKR1A1 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2
Sources

Drugs & Therapeutics for Metabolic Acidosis

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Drugs for Metabolic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 154)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Clonidine Approved Phase 4 4205-90-7 2803
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Nefopam Approved, Investigational Phase 4 13669-70-0
6
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
7
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
8
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
9
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
10
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
13
Racepinephrine Approved Phase 4 329-65-7 838
14
Dobutamine Approved Phase 4 34368-04-2 36811
15
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
16
Sodium citrate Approved, Investigational Phase 4 68-04-2
17
tannic acid Approved Phase 4 1401-55-4
18
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
19
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
20
Zinc Approved, Investigational Phase 4 7440-66-6 32051
21
Insulin Aspart Approved Phase 4 116094-23-6 16132418
22
carbamide peroxide Approved Phase 4 124-43-6
23
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
24
Norepinephrine Approved Phase 4 51-41-2 439260
25
Phenylephrine Approved Phase 4 59-42-7 6041
26
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
27
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
28
Lorazepam Approved Phase 4 846-49-1 3958
29
Ethanol Approved Phase 4 64-17-5 702
30
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
31
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
32
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
33 Simendan Investigational Phase 4 131741-08-7
34 Anesthetics, Intravenous Phase 4
35 Insulin, Short-Acting Phase 4
36 Calamus Phase 4
37 Anesthetics, Local Phase 4
38 Narcotics Phase 4
39 Adjuvants, Anesthesia Phase 4
40 Antipyretics Phase 4
41 Analgesics, Opioid Phase 4
42 Antioxidants Phase 4
43 Chelating Agents Phase 4
44 Expectorants Phase 4
45 Anticoagulants Phase 4
46 Calcium, Dietary Phase 4
47 calcium heparin Phase 4
48 N-monoacetylcystine Phase 4
49 Free Radical Scavengers Phase 4
50 Antidotes Phase 4

Interventional clinical trials:

(show top 50) (show all 186)
# Name Status NCT ID Phase Drugs
1 Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluids in Patients Undergoing Renal Transplantation. Unknown status NCT03115060 Phase 4 intravenous fluid administration WITH NORMAL SALINE, PLASMALYTE A, OR RINGER LACTATE
2 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
3 Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy Unknown status NCT03112538 Phase 4 Multiple daily injections of insulin
4 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
5 Comparing Heated Humidified High-flow Nasal Cannula Therapy and Nasal Continuous Positive Airway Pressure (nCPAP) Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants Less Than 32 Weeks' Gestational Age: Randomized Clinical Trial Unknown status NCT02887846 Phase 4
6 Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital Completed NCT03879356 Phase 4 N-acetyl cysteine
7 Randomized Controlled Trial of Intravenous Fluid In Severely Injured Paediatric Trauma Patients: Comparison of Normal Saline Versus Ringer's Lactate Completed NCT01692769 Phase 4 Normal Saline;Ringer's Lactate
8 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy in Critically Ill Patients With Acute Renal Failure: a Randomized Controlled Trial Completed NCT01269112 Phase 4
9 A Feasibility Randomised Controlled Trial: Effects of Oral Sodium Bicarbonate Supplementation in Patients on Haemodialysis Completed NCT02692378 Phase 4 sodium bicarbonate 500mg capsules
10 Effect of Oral Vitamin C on The Inflammatory Biomarkers in Hemodialysis Completed NCT01356433 Phase 4 oral vitamin C;oral vitamin C
11 Assessing the Safety of a Continuous Potassium Chloride Infusion in Critical Care: A Randomised Controlled Trial Completed NCT00718068 Phase 4 Sterile Potassium Chloride Concentrate;Sterile Potassium Chloride Concentrate
12 Randomized, Long-Term Administration of pH-Neutral PD Solutions Containing Lactate (BALANCE) or Bicarbonate (BICAVERA) in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
13 The Effects of Levosimendan on Renal Function in Patients With Low Ejection Fraction Undergoing Mitral Valve Surgery. Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
14 Effect of Arterial pH on N-balances of Patients Undergoing Automated Peritoneal Dialysis Completed NCT00586131 Phase 4 ammonium chloride or sodium citrate/citric acid;Sodium citrate/citratic acid
15 A Randomized Placebo Controlled Double Blind Investigation of the Effects of Potassium Citrate on Bone Metabolism in Postmenopausal Osteopenia Completed NCT00357331 Phase 4 potassium citrate
16 High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy: a Pragmatic Randomized Control Trial Recruiting NCT03846258 Phase 4 Low bicarbonate solution (22 mmol/L);High Bicarbonate solution (32 mmol/L)
17 Prospective Evaluation of Oral Alkalinization by Urologists and Nephrologists: Evolution of the Extracellular Compartment Recruiting NCT03035812 Phase 4 Alkali
18 A Single-center Randomized Double Blinded Control Trial of Intravenous Fluid Content in Children With Diabetic Ketoacidosis Admitted to the Pediatric Intensive Care Unit Recruiting NCT03066440 Phase 4 Normal saline;Lactated Ringers
19 Open-label, Randomized, Controlled, With Blind Assessor, Study to Assess Efficacy and Safety of Rheosorbilact®, Solution for Infusion ("Yuria-Pharm"), in Comparison With Ringer's Lactate,Solution for Infusion, in a Complex Therapy of Pneumonia. Recruiting NCT03824457 Phase 4 Rheosorbilact®;Ringer lactate
20 Open-label, Randomized, Controlled, With Blind Assessor, Study to Assess Efficacy and Safety of Rheosorbilact®, Solution for Infusion, in Comparison With Ringer's Lactate,Solution for Infusion, in a Complex Therapy of Peritonitis. Recruiting NCT03771170 Phase 4 Rheosorbilact®;Ringer lactate
21 Open-label, Randomized, Controlled, With Blind Assessor, Study to Assess Efficacy and Safety of Rheosorbilact®, Solution for Infusion, in Comparison With Ringer's Lactate, Solution for Infusion, in a Complex Therapy of Sepsis. Recruiting NCT03764085 Phase 4 Rheosorbilact®;Ringer lactate
22 Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane Recruiting NCT03384563 Phase 4 Dexmedetomidine
23 Impact of Early CRRT or Beta-blocker Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A 2 × 2 Partial Factorial Randomized Controlled Trial Recruiting NCT03549923 Phase 4 Esmolol;Standard care
24 Preservation of Kidney Function in Kidney Transplant Recipients by Alkali Therapy (Preserve-Transplant Study): a Multi-center Randomized Single-blind Placebo- Controlled Trial Active, not recruiting NCT03102996 Phase 4 Nephrotrans
25 InSaKa Trial: Insulin Dextrose Infusion Versus Nebulized Salbutamol Versus Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia: a Randomized Clinical Trial Not yet recruiting NCT04012138 Phase 4 Salbutamol;Insulin Aspart
26 A Double-Blind, Randomized, Comparative Efficacy and Safety Trial of Intravenous Solutions for the Treatment of Moderate to Severe Dehydration in Children With Acute Gastroenteritis Terminated NCT01234883 Phase 4 multiple electrolyte solution;saline
27 Randomized, Multicenter Cross-over Study in Investigating the Effect of Bicarbonate-based Solutions (Physioneal 35 vs. 40) on Protein Metabolism in Children and Adolescents on Chronic Peritoneal Dialysis Terminated NCT00776191 Phase 4 Physioneal 35;Physioneal 40
28 Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support, a Randomized Controlled Double-blind Trial Terminated NCT02414555 Phase 4 vasopressor;fluid bolus;Normal Saline;Elo-Mel Isoton (balanced acetat-based infusate)
29 A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Dexmedetomidine (Precedex®), With Lorazepam Rescue, for the Management of Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD) Terminated NCT01362205 Phase 4 Dexmedetomidine;Placebos
30 Forced Fluid Removal vs. Usual Intensive Care in High-risk Acute Kidney Injury With Severe Fluid Overload - A Randomized Controlled Trial Terminated NCT02458157 Phase 4 Furosemide (Furix)
31 A Prospective, Controlled, Randomized, Multicentric Study: Correction of Metabolic Acidosis With Use of Bicarbonate in Chronic Renal Insufficiency (CKD3b-4) Unknown status NCT01640119 Phase 3
32 Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU) Unknown status NCT02476253 Phase 3 Sodium Bicarbonate
33 Comparative Analysis Between Ringer's Lactate vs Acetate Containing Balanced Crystalloid Solution (Plasma Lyte-A) as Cardiopulmonary Bypass Prime Unknown status NCT03043131 Phase 3 Plasmalyte A;Ringer Lactate
34 A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis Completed NCT03317444 Phase 3 TRC101;Placebo
35 A Blinded, Placebo-Controlled Extension to Study TRCA-301 to Evaluate the Long-term Safety and Durability of Effect of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis Completed NCT03390842 Phase 3 TRC101;Placebo
36 Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects Completed NCT00888290 Phase 2, Phase 3 Sodium bicarbonate
37 Balanced Salt Solution Versus Normal Saline Solution During Initial Resuscitation in Severe Sepsis or Septic Shock Children: A Randomized Controlled Trial Completed NCT02336620 Phase 3 Ringer acetate;Normal saline
38 Effect of Neutralization of Endogenous Acid Production on Bone Mineral Density and Microarchitectural Composition of Bone in Humans Completed NCT00509405 Phase 3 potassium citrate
39 Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit Completed NCT02444988 Phase 3
40 Isotonic Solutions and Major Adverse Renal Events Trial in Non-Medical Intensive Care Units Completed NCT02547779 Phase 3
41 Study of Metformin HCL in Patients With Type 2 Diabetes Intensively Treated With Insulin: a Treatment Strategy for Insulin Resistance in Type 2 Diabetes Mellitus: a Randomized Controlled Trial Completed NCT00375388 Phase 3 Metformin on top of intensive insulin therapy
42 The Clinical Efficacy and Safety of a Proprietary Solution Containing Hypertonic Sodium Lactate (Totilac®) Infusion for Resuscitation of Patients With Hemorrhagic Shock Due to Multiple Injuries Completed NCT01433276 Phase 3 Hyperosmolar sodium lactate;Ringer's lactate
43 Efficacy of Albumin Administration for Volume Replacement in Patients With Severe Sepsis or Septic Shock - the ALBumin Italian Outcome Sepsis (ALBIOS) Study Completed NCT00707122 Phase 3
44 A Phase 3b, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of TRC101 in Delaying Chronic Kidney Disease Progression in Subjects With Metabolic Acidosis Recruiting NCT03710291 Phase 3 TRC101;Placebo
45 A Phase 3 Multicenter, Randomized, Double-Blinded, Placebo-Controlled Withdrawal Study Evaluating ADV7103 In Pediatric and Adult Subjects With Distal Renal Tubular Acidosis (dRTA) Recruiting NCT03644706 Phase 3 ADV7103;Placebos
46 The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients Recruiting NCT03277677 Phase 3 Normal saline;Ringer's Acetate
47 A Randomized, Open Label, Active Control, 2 Parallel Groups, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of Balanced Salt Solution Versus 0.9% Saline in Patients With High Risk of Contrast Induced Nephropathy. Recruiting NCT02799368 Phase 3 CJ Plasma Solution A Injection;CJ 0.9% Normal Saline Injection
48 An Investigator-initiated, Pragmatic, Registry-based, Multi-centre, Double-blind, Randomised Controlled Trial Evaluating the Effect of Plasmalyte Versus 0.9% Saline on Early Kidney Transplant Function in Deceased Donor Kidney Transplantation Recruiting NCT03829488 Phase 3 Plasma-Lyte 148 (approx. pH 7.4) IV Infusion;0.9% SODIUM CHLORIDE 9g/L injection BP
49 Clearance of Acetate During Fluid Resuscitation of Critically Ill Burn Patients: The CARE Trial. Active, not recruiting NCT03118362 Phase 3 Plasmalyte;Ringer lactate
50 A Phase 3B Open-Label Extension Of Study B23CS (ARENA 2) Evaluating The Continued Safety And Efficacy Of ADV7103 In Subjects With Primary Distal Renal Tubular Acidosis Not yet recruiting NCT03831152 Phase 3 ADV7103

Search NIH Clinical Center for Metabolic Acidosis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Sodium bicarbonate
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Genetic Tests for Metabolic Acidosis

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Genetic tests related to Metabolic Acidosis:

# Genetic test Affiliating Genes
1 Metabolic Acidosis 29
Sources

Anatomical Context for Metabolic Acidosis

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MalaCards organs/tissues related to Metabolic Acidosis:

41
Kidney, Liver, Bone, Heart, Brain, Lung, Testes
Sources

Publications for Metabolic Acidosis

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Articles related to Metabolic Acidosis:

(show top 50) (show all 10905)
# Title Authors PMID Year
1
Band 3 Edmonton I, a novel mutant of the anion exchanger 1 causing spherocytosis and distal renal tubular acidosis. 9 38
20028337 2010
2
[Late onset 3-HMG-CoA lyase deficiency: a rare but treatable disorder]. 9 38
19932602 2010
3
Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study. 9 38
19885998 2009
4
[Diagnosis, treatment and gene mutation analysis in children with holocarboxylase synthetas deficiency]. 9 38
19695181 2009
5
Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea. 9 38
19158801 2009
6
Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts. 9 38
19300448 2009
7
Equivalent metabolic acidosis with four colloids and saline on ex vivo haemodilution. 9 38
19499860 2009
8
Correction of metabolic acidosis on serum albumin and protein catabolism in hemodialysis patients. 9 38
19218045 2009
9
[Ethylene glycol intoxication. Important differential diagnosis in comatose patients with metabolic acidosis]. 9 38
18958433 2009
10
Risk factors in patients surgically treated for peptic ulcer perforation. 9 38
18785067 2009
11
Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia. 9 38
19087326 2008
12
[Case of severe streptococcus pyogenes pneumonia with streptococcus toxic shock syndrome]. 9 38
18592996 2008
13
Poisoning with 1-propanol and 2-propanol. 9 38
18375643 2007
14
Profound metabolic acidosis and oxoprolinuria in an adult. 9 38
18072147 2007
15
Distal renal tubular acidosis associated with anion exchanger 1 mutations in children in Thailand. 9 38
17533027 2007
16
Inborn errors in the metabolism of glutathione. 9 38
17397529 2007
17
Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells. 9 38
17183249 2007
18
Long-term oral sodium bicarbonate supplementation does not improve serum albumin levels in hemodialysis patients. 9 38
17409769 2007
19
Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA. 9 38
16219914 2006
20
Holocarboxylase synthetase deficiency presenting as ichthyosis. 9 38
16650223 2006
21
The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA). 9 38
16503241 2006
22
Brain abnormalities in a case of malonyl-CoA decarboxylase deficiency. 9 38
16275149 2006
23
Localization of NBC1 variants in rat kidney. 9 38
16785749 2006
24
[Serum creatine kinase activity in dogs and cats with metabolic diseases]. 9 38
16240913 2005
25
Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment. 9 38
15957126 2005
26
Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. 9 38
15771438 2005
27
Predictors of multi-organ dysfunction in heatstroke. 9 38
15735266 2005
28
Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. 9 38
15712076 2005
29
[Factors predisposing to malnutrition development in the patients on maintenance hemodialysis]. 9 38
16334531 2005
30
Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. 9 38
15607573 2005
31
[Gluthathion synthetase deficit in a newborn infant]. 9 38
15519833 2004
32
Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS). 9 38
15384017 2004
33
Is an intravenous fluid bolus of albumin or normal saline beneficial in the treatment of metabolic acidosis in a normovolaemic newborn? 9 38
15321875 2004
34
Regulation of aquaporin-2 by metabolic acidosis. 9 38
15308467 2004
35
[The short term prognosis in alcoholic liver disease with metabolic acidosis]. 9 38
15218345 2004
36
Coordinated increase in albumin, fibrinogen, and muscle protein synthesis during hemodialysis: role of cytokines. 9 38
14722024 2004
37
Aldosterone resistance in kidney transplantation is in part induced by a down-regulation of mineralocorticoid receptor expression. 9 38
15016134 2004
38
A novel nonsense mutation of the mineralocorticoid receptor gene in a Swedish family with pseudohypoaldosteronism type I (PHA1). 9 38
14715854 2004
39
Successful orthotopic liver transplantation after trimethoprim-sulfamethoxazole associated fulminant liver failure. 9 38
14703931 2003
40
[Nephrogenic metabolic acidosis]. 9 38
12908170 2003
41
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. 9 38
12515852 2003
42
Mechanisms of bilirubin toxicity: clinical implications. 9 38
12516745 2002
43
[Severe ethylene glycol poisoning treated wtih fomepizole (4-methylpyrazole)]. 9 38
12448112 2002
44
Pyruvate carboxylase deficiency--insights from liver transplantation. 9 38
12359142 2002
45
Systemic pseudohypoaldosteronism from deletion of the promoter region of the human Beta epithelial na(+) channel subunit. 9 38
12204893 2002
46
Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease, erythropoietin treatment, and type of heparin in haemodialysis patients. 9 38
11917058 2002
47
[Hyperchloremic acidosis druing plasma volume replacement]. 9 38
11963385 2002
48
The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis. 9 38
12027224 2002
49
[Role of the Na(+)-K+(NH4+)-2Cl cotransporter of the medullary ascending limb in the regulation of renal acid-base equilibrium]. 9 38
12227253 2002
50
Acute metabolic acidosis decreases muscle protein synthesis but not albumin synthesis in humans. 9 38
11728951 2001
Sources

Variations for Metabolic Acidosis

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Expression for Metabolic Acidosis

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Search GEO for disease gene expression data for Metabolic Acidosis.
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Pathways for Metabolic Acidosis

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Pathways related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metabolism 66
Show member pathways
 13.72 SLC9A1 SLC4A1 MLYCD HMGCL HLCS GSS
2
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 66
Show member pathways
 12.78 WNK4 SLC9A3 SLC9A1 SLC4A4 SLC4A1 SCNN1G
3
Ion channel transport 66
Show member pathways
 12.23 WNK4 SCNN1G ATP6V1B1 ATP6V0A4
4
Glucose / Energy Metabolism 4
12.2 SLC4A4 FBP1 CA2 AQP2
5
Insulin receptor recycling 66
Show member pathways
 12.12 SLC4A1 CA2 ATP6V1B1 ATP6V0A4
6
Pancreatic secretion 37
11.51 SLC9A1 SLC4A4 CA2
7
Bile secretion 37
11.31 SLC9A3 SLC9A1 SLC4A4 CA2
8
Proximal tubule bicarbonate reclamation 37
10.29 SLC9A3 SLC4A4 GLS2 CA2
Sources

GO Terms for Metabolic Acidosis

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Cellular components related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.63 SLC9A1 SLC4A4 SLC4A1 CA2 ATP6V1B1 AQP2
2 apical plasma membrane GO:0016324 9.5 SLC9A3 SLC9A1 SCNN1G ATP6V1B1 ATP6V0A4 AQP2
3 extracellular exosome GO:0070062 9.44 SLC9A3 SLC9A1 SLC4A4 SLC4A1 SCNN1G GSS
4 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.26 ATP6V1B1 ATP6V0A4

Biological processes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.76 WNK4 SLC9A3 SLC9A1 SLC4A4 SLC4A1 SCNN1G
2 sodium ion transport GO:0006814 9.71 SLC9A3 SLC9A1 SLC4A4 SCNN1G
3 ossification GO:0001503 9.69 BGLAP ATP6V1B1 ATP6V0A4
4 proton transmembrane transport GO:1902600 9.67 SLC9A3 SLC9A1 ATP6V1B1 ATP6V0A4
5 sodium ion transmembrane transport GO:0035725 9.65 SLC9A3 SLC9A1 SCNN1G
6 bicarbonate transport GO:0015701 9.63 SLC4A4 SLC4A1 CA2
7 anion transport GO:0006820 9.54 SLC4A4 SLC4A1
8 sodium ion import across plasma membrane GO:0098719 9.52 SLC9A3 SLC9A1
9 ion homeostasis GO:0050801 9.49 WNK4 KLHL3
10 renal sodium ion absorption GO:0070294 9.43 WNK4 KLHL3
11 excretion GO:0007588 9.43 SCNN1G ATP6V1B1 ATP6V0A4
12 distal tubule morphogenesis GO:0072156 9.32 WNK4 KLHL3
13 regulation of pH GO:0006885 9.26 SLC9A3 SLC9A1 ATP6V1B1 ATP6V0A4
14 regulation of intracellular pH GO:0051453 9.02 SLC9A3 SLC9A1 SLC4A4 SLC4A1 CA2

Molecular functions related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 solute:proton antiporter activity GO:0015299 9.32 SLC9A3 SLC9A1
2 inorganic anion exchanger activity GO:0005452 9.26 SLC4A4 SLC4A1
3 anion transmembrane transporter activity GO:0008509 9.16 SLC4A4 SLC4A1
4 sodium:proton antiporter activity GO:0015385 8.96 SLC9A3 SLC9A1
5 potassium:proton antiporter activity GO:0015386 8.62 SLC9A3 SLC9A1
6 protein binding GO:0005515 10.27 WNK4 SLC9A3 SLC9A1 SLC4A4 SLC4A1 SCNN1G
Sources

Sources for Metabolic Acidosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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