MCID: MTB004
MIFTS: 48

Metabolic Acidosis

Categories: Metabolic diseases

Aliases & Classifications for Metabolic Acidosis

MalaCards integrated aliases for Metabolic Acidosis:

Name: Metabolic Acidosis 12 74 29 54 6 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050758
UMLS 71 C0220981

Summaries for Metabolic Acidosis

Disease Ontology : 12 An acquired metabolic disease that characterized by excessive production of acid.

MalaCards based summary : Metabolic Acidosis is related to distal renal tubular acidosis and renal tubular acidosis. An important gene associated with Metabolic Acidosis is GSS (Glutathione Synthetase), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Sodium citrate and carbamide peroxide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's... more...

Related Diseases for Metabolic Acidosis

Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 440)
# Related Disease Score Top Affiliating Genes
1 distal renal tubular acidosis 32.7 SLC4A1 CA2 ATP6V1B1
2 renal tubular acidosis 32.1 SLC9A3 SLC4A4 SLC4A1 CA2 ATP6V1B1
3 renal tubular acidosis, distal, 3, with or without sensorineural hearing loss 32.1 SLC4A1 ATP6V1B1
4 autosomal recessive distal renal tubular acidosis 32.0 SLC4A1 ATP6V1B1
5 organic acidemia 30.7 HMGCL HLCS BTD
6 nephrolithiasis 30.6 SLC4A1 BGLAP ATP6V1B1
7 fanconi syndrome 30.5 SLC9A3 SLC4A4 OGDH ALB
8 nephrocalcinosis 30.4 SLC4A1 CA2 ATP6V1B1
9 autosomal recessive disease 30.4 MLYCD HMGCL GLS ATP6V1B1
10 primary biliary cholangitis 30.2 OGDH CA2 BGLAP ALB
11 central pontine myelinolysis 30.1 AQP2 ALB
12 meconium ileus 29.8 SLC9A3 SLC4A4
13 hypertension, essential 29.5 WNK4 SLC9A3 SLC9A1 SLC4A4 KLHL3 AQP2
14 glutathione synthetase deficiency 11.4
15 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.3
16 pseudohypoaldosteronism, type iie 11.3
17 ovarian dysgenesis, hypergonadotropic, with short stature and recurrent metabolic acidosis 11.3
18 lactic acidosis 11.3
19 fructose-1,6-bisphosphatase deficiency 11.3
20 multiple acyl-coa dehydrogenase deficiency 11.2
21 hawkinsinuria 11.2
22 mitochondrial complex iv deficiency, nuclear type 5 11.2
23 malonyl-coa decarboxylase deficiency 11.2
24 3-methylglutaconic aciduria, type i 11.2
25 pseudohypoaldosteronism, type i, autosomal recessive 11.2
26 fumarase deficiency 11.2
27 mitochondrial trifunctional protein deficiency 11.2
28 mitochondrial complex i deficiency, nuclear type 20 11.2
29 renal tubular acidosis with deafness 11.2
30 slc4a1-associated distal renal tubular acidosis 11.2
31 carbonic anhydrase va deficiency, hyperammonemia due to 11.1
32 diabetes mellitus, ketosis-prone 11.1
33 d-glyceric aciduria 11.1
34 malignant hyperthermia 1 11.1
35 holocarboxylase synthetase deficiency 11.1
36 mitochondrial dna depletion syndrome 6 11.1
37 hsd10 mitochondrial disease 11.1
38 renal tubular acidosis, distal, 4, with hemolytic anemia 11.1
39 pseudohypoaldosteronism, type iid 11.1
40 fanconi renotubular syndrome 3 11.1
41 carbonic anhydrase va deficiency 11.1
42 autosomal dominant distal renal tubular acidosis 11.1
43 corticosterone methyloxidase deficiency 11.1
44 hypoaldosteronism 11.0
45 renal tubular acidosis, proximal 11.0
46 asphyxia neonatorum 11.0
47 lowe oculocerebrorenal syndrome 11.0
48 propionic acidemia 11.0
49 pseudohypoaldosteronism, type iia 10.9
50 renal tubular acidosis, distal, 1 10.9

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to Metabolic Acidosis

Symptoms & Phenotypes for Metabolic Acidosis

GenomeRNAi Phenotypes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.58 WNK4
2 Decreased viability GR00221-A-2 9.58 WNK4
3 Decreased viability GR00221-A-4 9.58 WNK4
4 Decreased viability GR00249-S 9.58 ALB CA2 GLS HLCS OGDH
5 Decreased viability GR00381-A-1 9.58 MLYCD
6 Decreased viability GR00386-A-1 9.58 ALB GLS GLS2 HMGCL OGDH SLC4A4
7 Decreased viability GR00402-S-2 9.58 GLS2 OGDH

MGI Mouse Phenotypes related to Metabolic Acidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ALB ATP6V1B1 GLS HMGCL KLHL3 MLYCD
2 homeostasis/metabolism MP:0005376 9.83 ALB AQP2 ATP6V1B1 BGLAP BTD CA2
3 renal/urinary system MP:0005367 9.32 ALB AQP2 ATP6V1B1 BTD CA2 KLHL3

Drugs & Therapeutics for Metabolic Acidosis

Drugs for Metabolic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 4 68-04-2
2
carbamide peroxide Approved Phase 4 124-43-6
3
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
4
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
5 Citrate Phase 4
6 Calcium, Dietary Phase 4
7 Anticoagulants Phase 4
8 Chelating Agents Phase 4
9 Pharmaceutical Solutions Phase 4
10 diuretics Phase 4
11 Sodium Potassium Chloride Symporter Inhibitors Phase 4
12 Vasoconstrictor Agents Phase 4
13
Calcium Nutraceutical Phase 4 7440-70-2 271
14
Potassium citrate Approved, Investigational, Vet_approved Phase 3 866-84-2
15
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
16
tannic acid Approved Phase 3 1401-55-4
17 Respiratory System Agents Phase 3
18 Expectorants Phase 3
19
Guaifenesin Approved, Investigational, Vet_approved Phase 1, Phase 2 93-14-1 3516
20
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
21 Chlorpheniramine, phenylpropanolamine drug combination Phase 1, Phase 2
22
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
23
Sevoflurane Approved, Vet_approved 28523-86-6 5206
24
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
25
Naloxone Approved, Vet_approved 465-65-6 5284596
26
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
27 Angiotensin-Converting Enzyme Inhibitors
28 Antihypertensive Agents
29 Hypnotics and Sedatives
30 Anesthetics, General
31 Anesthetics
32 Anesthetics, Intravenous
33 Dialysis Solutions
34 Albuterol
35 Insulin, Globin Zinc
36 Polystyrene sulfonic acid
37 insulin

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Effect of Arterial pH on N-balances of Patients Undergoing Automated Peritoneal Dialysis Completed NCT00586131 Phase 4 ammonium chloride or sodium citrate/citric acid;Sodium citrate/citratic acid
2 Prospective Evaluation of Oral Alkalinization by Urologists and Nephrologists: Evolution of the Extracellular Compartment Completed NCT03035812 Phase 4 Alkali
3 High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy: a Pragmatic Randomized Control Trial Recruiting NCT03846258 Phase 4 Low bicarbonate solution (22 mmol/L);High Bicarbonate solution (32 mmol/L)
4 Forced Fluid Removal vs. Usual Intensive Care in High-risk Acute Kidney Injury With Severe Fluid Overload - A Randomized Controlled Trial Terminated NCT02458157 Phase 4 Furosemide (Furix)
5 A Prospective, Controlled, Randomized, Multicentric Study: Correction of Metabolic Acidosis With Use of Bicarbonate in Chronic Renal Insufficiency (CKD3b-4) Unknown status NCT01640119 Phase 3
6 Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill : A Multiple Center Randomized Clinical Trial (BICAR-ICU) Unknown status NCT02476253 Phase 3 Sodium Bicarbonate
7 Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects Completed NCT00888290 Phase 2, Phase 3 Sodium bicarbonate
8 Effect of Neutralization of Endogenous Acid Production on Bone Mineral Density and Microarchitectural Composition of Bone in Humans Completed NCT00509405 Phase 3 potassium citrate
9 A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis Completed NCT03317444 Phase 3 TRC101;Placebo
10 A Blinded, Placebo-Controlled Extension to Study TRCA-301 to Evaluate the Long-term Safety and Durability of Effect of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis Completed NCT03390842 Phase 3 TRC101;Placebo
11 A Phase 3b, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of TRC101 in Delaying Chronic Kidney Disease Progression in Subjects With Metabolic Acidosis Recruiting NCT03710291 Phase 3 TRC101;Placebo
12 A Double-blind Randomized Placebo-controlled Parallel Design Multicenter Phase IIIb Study of the Effect of Sodium Zirconium Cyclosilicate (SZC) on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease (NEUTRALIZE) Not yet recruiting NCT04727528 Phase 3 Sodium zirconium cyclosilicate;Placebo
13 Impact on Mortality of the Timing of Renal Replacement Therapy in Patients With Severe Acute Kidney Injury in Septic Shock: the IDEAL-ICU Study (Initiation of Dialysis Early Versus Delayed in the Intensive Care Unit): Study Protocol for a Randomized Controlled Trial Terminated NCT01682590 Phase 3
14 A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of TRC101 in Subjects With Chronic Kidney Disease and Low Serum Bicarbonate Levels Completed NCT02809183 Phase 1, Phase 2 Placebo;TRC101
15 Metabolic Acidosis and Its Impact on Mineral Metabolism and Physical Performance in Renal Transplant Patients Completed NCT00913796 Phase 2 Potassium citrate;Potassium chloride
16 Hypoxic-Ischemic Encephalopathy Therapy Optimization for Better Neuroprotection With Inhalative CO2 in Asphyxiated, Cooled, Mechanically Ventilated Neonates at Risk for Hypocapnia Unknown status NCT02700854 Phase 1
17 Incidence of Postoperative Ketosis and Metabolic Acidosis Unknown status NCT01860001
18 Renal Tubular Acidosis in Incident Renal Transplant Recipients Unknown status NCT01283880
19 On Demand Versus Protocol-guided Renal Replacement Therapy for Management of Stage 3 Acute Kidney Injury in Patients With Cirrhosis -A Prospective Randomized Controlled Trial Unknown status NCT02937935
20 The Contribution of Intraoperative Mechanical Red Cell Salvage to Acidosis in the Immediate Postoperative Period After Cardiac Surgery Unknown status NCT02800343
21 Perioperative Fluid Management in Patients Receiving Cadaveric Renal Transplants - Effects of Normal Saline Versus Balanced Infusates on the Incidence of Electrolyte and Acid-base Disturbances Completed NCT01075750
22 "Early" and "Late" Timing Indication for Starting Renal Replacement Therapy in Acute Renal Failure After Cardiac Surgery: a Prospective, Controlled, Interventional, Single-center Trial Completed NCT01961999
23 Nephrologic Intervention in Patients Waiting for Cardiac Surgery Completed NCT02643745
24 Study of Carbon Dioxide Removal to Alleviate Right Ventricule Dysfunction During Acute Respiratory Distress Syndrome Completed NCT03303807
25 Effect of Treatment of Metabolic Acidosis on Vascular Function in Patients With Chronic Kidney Disease: A Pilot Study Completed NCT02031770 Sodium bicarbonate
26 Effect of Propofol and Sevoflurane on Base Excess, pH and Lactate in Pediatric Heart Catheterisation Completed NCT01293266 Propofol
27 Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary Bypass: Effect on Metabolic Acidosis and Clinical Outcome Completed NCT01295190
28 Changes in Acid Base Status During High Salt Intake Completed NCT01655953
29 Effect of Ringer's Lactate on Maternal and Neonatal pH in Caesarean Section at Mulago Hospital, a Randomized Trial Completed NCT01585740 0.9% Normal Saline;Ringer's Lactate
30 Effect of Goal-directed Fluid Therapy Based on Stroke Volume Variation on Metabolic Acidosis in Patients Undergoing Brain Tumor Surgery Completed NCT01738880 SVV;CVP
31 The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity Completed NCT02896309
32 Autophagy, Mitophagy, Inflammation and Plasmatic Concentration of Melatonin in Newborn With Metabolic Acidosis at Birth Recruiting NCT03897101
33 Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD Recruiting NCT04600323 Early Phase 1 Sodium Bicarbonate Tablets;Placebo
34 Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in the Critically Ill: a Randomized Clinical Trial Recruiting NCT04010630 Sodium bicarbonate infusion
35 The Influences of Dialysate Bicarbonate Concentrations on Hemodialysis Patients Not yet recruiting NCT04070690
36 Recovery After Dialysis-Requiring Acute Kidney Injury Pilot Study Terminated NCT03305549
37 Cardiotocography Combined With ST-analysis Versus Cardiotocography Combined With Scalp-pH in Deliveries With Abnormal CTG - A Randomised Trial Terminated NCT01699646

Search NIH Clinical Center for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

Genetic tests related to Metabolic Acidosis:

# Genetic test Affiliating Genes
1 Metabolic Acidosis 29

Anatomical Context for Metabolic Acidosis

MalaCards organs/tissues related to Metabolic Acidosis:

40
Kidney, Heart, Brain, Skeletal Muscle, Pancreas, Bone, Colon

Publications for Metabolic Acidosis

Articles related to Metabolic Acidosis:

(show top 50) (show all 11562)
# Title Authors PMID Year
1
Band 3 Edmonton I, a novel mutant of the anion exchanger 1 causing spherocytosis and distal renal tubular acidosis. 61 54
20028337 2010
2
[Late onset 3-HMG-CoA lyase deficiency: a rare but treatable disorder]. 54 61
19932602 2010
3
Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study. 54 61
19885998 2009
4
[Diagnosis, treatment and gene mutation analysis in children with holocarboxylase synthetas deficiency]. 54 61
19695181 2009
5
Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea. 61 54
19158801 2009
6
Acute and chronic metabolic acidosis interferes with aquaporin-2 translocation in the rat kidney collecting ducts. 54 61
19300448 2009
7
Equivalent metabolic acidosis with four colloids and saline on ex vivo haemodilution. 54 61
19499860 2009
8
Correction of metabolic acidosis on serum albumin and protein catabolism in hemodialysis patients. 54 61
19218045 2009
9
[Ethylene glycol intoxication. Important differential diagnosis in comatose patients with metabolic acidosis]. 61 54
18958433 2009
10
Risk factors in patients surgically treated for peptic ulcer perforation. 54 61
18785067 2009
11
Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia. 54 61
19087326 2008
12
[Case of severe streptococcus pyogenes pneumonia with streptococcus toxic shock syndrome]. 54 61
18592996 2008
13
Poisoning with 1-propanol and 2-propanol. 61 54
18375643 2007
14
Profound metabolic acidosis and oxoprolinuria in an adult. 54 61
18072147 2007
15
Distal renal tubular acidosis associated with anion exchanger 1 mutations in children in Thailand. 61 54
17533027 2007
16
Inborn errors in the metabolism of glutathione. 61 54
17397529 2007
17
Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells. 54 61
17183249 2007
18
Long-term oral sodium bicarbonate supplementation does not improve serum albumin levels in hemodialysis patients. 54 61
17409769 2007
19
Holocarboxylase synthetase deficiency presenting as ichthyosis. 54 61
16650223 2006
20
The anion gap (AG): studies in the nephrotic syndrome and diabetic ketoacidosis (DKA). 54 61
16503241 2006
21
Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA. 61 54
16219914 2006
22
Brain abnormalities in a case of malonyl-CoA decarboxylase deficiency. 54 61
16275149 2006
23
Localization of NBC1 variants in rat kidney. 61 54
16785749 2006
24
[Serum creatine kinase activity in dogs and cats with metabolic diseases]. 54 61
16240913 2005
25
Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment. 54 61
15957126 2005
26
Predictors of multi-organ dysfunction in heatstroke. 61 54
15735266 2005
27
Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. 61 54
15771438 2005
28
Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. 61 54
15712076 2005
29
Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. 61 54
15607573 2005
30
[Factors predisposing to malnutrition development in the patients on maintenance hemodialysis]. 54 61
16334531 2005
31
[Gluthathion synthetase deficit in a newborn infant]. 54 61
15519833 2004
32
Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study (DOPPS). 54 61
15384017 2004
33
Regulation of aquaporin-2 by metabolic acidosis. 54 61
15308467 2004
34
Is an intravenous fluid bolus of albumin or normal saline beneficial in the treatment of metabolic acidosis in a normovolaemic newborn? 61 54
15321875 2004
35
[The short term prognosis in alcoholic liver disease with metabolic acidosis]. 61 54
15218345 2004
36
Aldosterone resistance in kidney transplantation is in part induced by a down-regulation of mineralocorticoid receptor expression. 61 54
15016134 2004
37
Coordinated increase in albumin, fibrinogen, and muscle protein synthesis during hemodialysis: role of cytokines. 54 61
14722024 2004
38
A novel nonsense mutation of the mineralocorticoid receptor gene in a Swedish family with pseudohypoaldosteronism type I (PHA1). 61 54
14715854 2004
39
Successful orthotopic liver transplantation after trimethoprim-sulfamethoxazole associated fulminant liver failure. 54 61
14703931 2003
40
[Nephrogenic metabolic acidosis]. 54 61
12908170 2003
41
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. 61 54
12515852 2003
42
Mechanisms of bilirubin toxicity: clinical implications. 54 61
12516745 2002
43
[Severe ethylene glycol poisoning treated wtih fomepizole (4-methylpyrazole)]. 61 54
12448112 2002
44
Pyruvate carboxylase deficiency--insights from liver transplantation. 54 61
12359142 2002
45
Systemic pseudohypoaldosteronism from deletion of the promoter region of the human Beta epithelial na(+) channel subunit. 61 54
12204893 2002
46
Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease, erythropoietin treatment, and type of heparin in haemodialysis patients. 61 54
11917058 2002
47
The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis. 54 61
12027224 2002
48
[Hyperchloremic acidosis druing plasma volume replacement]. 54 61
11963385 2002
49
[Role of the Na(+)-K+(NH4+)-2Cl cotransporter of the medullary ascending limb in the regulation of renal acid-base equilibrium]. 61 54
12227253 2002
50
Acute metabolic acidosis decreases muscle protein synthesis but not albumin synthesis in humans. 61 54
11728951 2001

Variations for Metabolic Acidosis

ClinVar genetic disease variations for Metabolic Acidosis:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CA1 NM_001128831.4(CA1):c.368_369del (p.His123fs) Deletion Uncertain significance 694733 rs768769200 8:86245835-86245836 8:85333606-85333607
2 HADHB NM_000183.3(HADHB):c.110-2324G>C SNV Uncertain significance 830363 2:26483924-26483924 2:26261056-26261056

Expression for Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for Metabolic Acidosis

Pathways related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 SLC9A1 SLC4A1 OGDH MLYCD HMGCL HLCS
2
Show member pathways
13.1 WNK4 SLC9A3 SLC9A1 SLC4A4 SLC4A1 ATP6V1B1
3 12.22 SLC4A4 FBP1 CA2 AQP2
4 11.52 OGDH HMGCL GSS GLS
5 11.41 SLC9A3 SLC9A1 SLC4A4 CA2
6 10.38 SLC9A3 SLC4A4 GLS2 GLS CA2
7
Show member pathways
10.25 GLS2 GLS
8 9.8 HLCS BTD

GO Terms for Metabolic Acidosis

Cellular components related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.8 SLC9A1 OGDH MLYCD HMGCL HLCS GLS2
2 extracellular exosome GO:0070062 9.7 SLC9A3 SLC9A1 SLC4A4 SLC4A1 GSS FBP1
3 mitochondrial matrix GO:0005759 9.63 OGDH MLYCD HMGCL GLS2 GLS BTD
4 apical plasma membrane GO:0016324 9.62 SLC9A3 SLC9A1 ATP6V1B1 AQP2
5 basolateral plasma membrane GO:0016323 9.1 SLC9A1 SLC4A4 SLC4A1 CA2 ATP6V1B1 AQP2

Biological processes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.96 SLC9A3 SLC9A1 SLC4A4 SLC4A1 AQP2
2 ion transport GO:0006811 9.95 WNK4 SLC9A3 SLC9A1 SLC4A4 SLC4A1 ATP6V1B1
3 sodium ion transport GO:0006814 9.75 SLC9A3 SLC9A1 SLC4A4
4 proton transmembrane transport GO:1902600 9.72 SLC9A3 SLC9A1 ATP6V1B1
5 sodium ion transmembrane transport GO:0035725 9.7 SLC9A3 SLC9A1 SLC4A4
6 bicarbonate transport GO:0015701 9.58 SLC4A4 SLC4A1 CA2
7 glutamine metabolic process GO:0006541 9.57 GLS2 GLS
8 sodium ion import across plasma membrane GO:0098719 9.54 SLC9A3 SLC9A1
9 sodium ion export across plasma membrane GO:0036376 9.51 SLC9A1 SLC4A4
10 biotin metabolic process GO:0006768 9.49 HLCS BTD
11 renal sodium ion absorption GO:0070294 9.46 WNK4 KLHL3
12 anion transmembrane transport GO:0098656 9.46 SLC9A3 SLC9A1 SLC4A4 SLC4A1
13 glutamate biosynthetic process GO:0006537 9.43 GLS2 GLS
14 regulation of pH GO:0006885 9.43 SLC9A3 SLC9A1 ATP6V1B1
15 glutamine catabolic process GO:0006543 9.37 GLS2 GLS
16 distal tubule morphogenesis GO:0072156 9.32 WNK4 KLHL3
17 ion homeostasis GO:0050801 9.26 WNK4 SLC4A4 SLC4A1 KLHL3
18 regulation of intracellular pH GO:0051453 9.02 SLC9A3 SLC9A1 SLC4A4 SLC4A1 CA2

Molecular functions related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 solute:proton antiporter activity GO:0015299 9.37 SLC9A3 SLC9A1
2 anion transmembrane transporter activity GO:0008509 9.32 SLC4A4 SLC4A1
3 inorganic anion exchanger activity GO:0005452 9.26 SLC4A4 SLC4A1
4 sodium:proton antiporter activity GO:0015385 9.16 SLC9A3 SLC9A1
5 potassium:proton antiporter activity GO:0015386 8.96 SLC9A3 SLC9A1
6 glutaminase activity GO:0004359 8.62 GLS2 GLS

Sources for Metabolic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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