MCID: MTB004
MIFTS: 48

Metabolic Acidosis

Categories: Metabolic diseases

Aliases & Classifications for Metabolic Acidosis

MalaCards integrated aliases for Metabolic Acidosis:

Name: Metabolic Acidosis 12 76 29 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050758
UMLS 73 C0220981

Summaries for Metabolic Acidosis

Disease Ontology : 12 An acquired metabolic disease that characterized by excessive production of acid.

MalaCards based summary : Metabolic Acidosis is related to renal tubular acidosis, distal and renal tubular acidosis, distal, autosomal recessive. An important gene associated with Metabolic Acidosis is HMGCL (3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Metformin and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia : 76 Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or... more...

Related Diseases for Metabolic Acidosis

Diseases related to Metabolic Acidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 renal tubular acidosis, distal 32.0 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
2 renal tubular acidosis, distal, autosomal recessive 31.7 ATP6V0A4 ATP6V1B1 SLC4A1
3 renal tubular acidosis 30.3 ATP6V0A4 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A3
4 medullary sponge kidney 30.0 ATP6V0A4 ATP6V1B1
5 propionic acidemia 29.2 HLCS HMGCL MLYCD
6 ovarian dysgenesis, hypergonadotropic, with short stature and recurrent metabolic acidosis 12.1
7 glutathione synthetase deficiency 11.4
8 fructose-1,6-bisphosphatase deficiency 11.4
9 lactic acidosis 11.3
10 pseudohypoaldosteronism, type iia 11.1
11 renal tubular acidosis, distal, autosomal dominant 11.0
12 leigh syndrome, french canadian type 11.0
13 multiple acyl-coa dehydrogenase deficiency 11.0
14 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.0
15 malonyl-coa decarboxylase deficiency 11.0
16 renal tubular acidosis, distal, with progressive nerve deafness 11.0
17 hawkinsinuria 11.0
18 malignant hyperthermia 1 11.0
19 d-glyceric aciduria 11.0
20 3-methylglutaconic aciduria, type i 11.0
21 fumarase deficiency 11.0
22 mitochondrial trifunctional protein deficiency 11.0
23 mitochondrial complex i deficiency due to acad9 deficiency 11.0
24 renal tubular acidosis, distal, with hemolytic anemia 11.0
25 pseudohypoaldosteronism, type iid 11.0
26 pseudohypoaldosteronism, type iie 11.0
27 carbonic anhydrase va deficiency, hyperammonemia due to 11.0
28 alpha-ketoglutarate dehydrogenase deficiency 10.8
29 arthrogryposis, renal dysfunction, and cholestasis 1 10.8
30 cranioectodermal dysplasia 1 10.8
31 hydroxykynureninuria 10.8
32 isovaleric acidemia 10.8
33 methylmalonyl-coa epimerase deficiency 10.8
34 mitochondrial myopathy with lactic acidosis 10.8
35 holocarboxylase synthetase deficiency 10.8
36 mitochondrial dna depletion syndrome 6 10.8
37 pseudohypoaldosteronism, type i, autosomal recessive 10.8
38 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 10.8
39 hsd10 mitochondrial disease 10.8
40 carnitine palmitoyltransferase ii deficiency, infantile 10.8
41 nephronophthisis 2 10.8
42 combined oxidative phosphorylation deficiency 2 10.8
43 combined oxidative phosphorylation deficiency 3 10.8
44 combined oxidative phosphorylation deficiency 5 10.8
45 pseudohypoaldosteronism, type iib 10.8
46 pseudohypoaldosteronism, type iic 10.8
47 mitochondrial pyruvate carrier deficiency 10.8
48 riboflavin deficiency 10.8
49 sudden cardiac failure, infantile 10.8
50 2-methyl-3-hydroxybutyric aciduria 10.8

Graphical network of the top 20 diseases related to Metabolic Acidosis:



Diseases related to Metabolic Acidosis

Symptoms & Phenotypes for Metabolic Acidosis

MGI Mouse Phenotypes related to Metabolic Acidosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 KLHL3 MLYCD SLC4A1 SLC4A4 SLC9A1 SLC9A3
2 renal/urinary system MP:0005367 9.28 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2 SLC4A1

Drugs & Therapeutics for Metabolic Acidosis

Drugs for Metabolic Acidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 388)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3 Parecoxib Approved Phase 4 198470-84-7
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
6
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
7
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
8
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
9
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
10
Insulin Glargine Approved Phase 4,Not Applicable 160337-95-1
11
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
12
Stavudine Approved, Investigational Phase 4,Phase 2,Phase 3 3056-17-5 18283
13
Ephedrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 299-42-3 9294
14
Oxymetazoline Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 1491-59-4 4636
15
Phenylephrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 59-42-7 6041
16
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 90-82-4 7028
17
Dopamine Approved Phase 4,Not Applicable 51-61-6, 62-31-7 681
18
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
19
Insulin glulisine Approved Phase 4 207748-29-6
20
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6 23994
21
Dobutamine Approved Phase 4,Phase 2,Not Applicable 34368-04-2 36811
22
Norepinephrine Approved Phase 4,Phase 2,Not Applicable 51-41-2 439260
23
Meperidine Approved Phase 4 57-42-1 4058
24
Remifentanil Approved Phase 4 132875-61-7 60815
25
Insulin Aspart Approved Phase 4,Not Applicable 116094-23-6 16132418
26
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
27
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
28
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
29
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
30
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
32
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-43-8, 70-16-6 1130
33
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
34
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 83-88-5 493570
35
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
36
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
37
Adefovir Investigational Phase 4 106941-25-7
38 Simendan Investigational Phase 4 131741-08-7
39 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
40 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
41 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
43 Ophthalmic Solutions Phase 4,Phase 3,Not Applicable
44 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Plasma-lyte 148 Phase 4,Phase 3,Not Applicable
46 Antipsychotic Agents Phase 4,Not Applicable
47 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
48 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
50 Tranquilizing Agents Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 408)
# Name Status NCT ID Phase Drugs
1 Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery Unknown status NCT01524315 Phase 4 Vitamin B1-ratiopharm;Placebo
2 Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation Unknown status NCT01513655 Phase 4
3 Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation Unknown status NCT00885404 Phase 4 Lower chloride fluids (Hartmann's solution and Plasmalyte®)
4 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
5 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
6 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
7 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4 Telbivudine;Enecavir;Adefovir
8 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
9 Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients. Unknown status NCT01228292 Phase 4 Unfractionated heparin;Citrasate
10 Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program Unknown status NCT02663960 Phase 4
11 Lactate Metabolism Study in HIV Infected Persons Completed NCT00202228 Phase 4 cofactor supplementation (thiamine, riboflavin, L-carnitine)
12 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI) Completed NCT01481740 Phase 4 Phenylephrine bolus;phenylephrine infusion
13 Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy Completed NCT01269112 Phase 4
14 Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients Completed NCT01356433 Phase 4 oral vitamin C;oral vitamin C
15 Administration of pH-Neutral Peritoneal Dialysis Solutions Containing Lactate or Bicarbonate in Children Completed NCT01632046 Phase 4 lactate and bicarbonate buffered dialysis solutions
16 Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass Completed NCT00747331 Phase 4 Fenoldopam mesilate;Placebo
17 Type 2 Diabetes and Ambulatory Surgery Patients Completed NCT03179254 Phase 4 Metformin continue;Metformin discontinue
18 Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS) Completed NCT01831934 Phase 4
19 Effect of Prime Solution on Fluid Balance After Open Heart Surgery Completed NCT00797589 Phase 4 HES;Ringer lactate
20 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
21 The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial Completed NCT01438723 Phase 4 Metformin;Placebo
22 ABRA Abdominal Closure System in Open Abdomen Management Completed NCT00754156 Phase 4
23 Arterial pH and Total Body Nitrogen Balances in APD Completed NCT00586131 Phase 4 ammonium chloride or sodium citrate/citric acid;Sodium citrate/citratic acid
24 Basal Insulin in the Management of Patients With Diabetic Ketoacidosis (DKA) Completed NCT00590044 Phase 4 insulin glargine+ glulisine;NPH + Regular insulin
25 Optiflow® to Prevent Post-Extubation Hypoxemia afteR Abdominal Surgery (the OPERA Trial) Completed NCT01887015 Phase 4
26 Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment Completed NCT01099618 Phase 4 metformin;placebo;Sitagliptin
27 Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients Completed NCT00778622 Phase 4 Metformin XR
28 The Effects of Levosimendan During Mitral Valve Surgery Completed NCT01969071 Phase 4 Levosimendan;Dobutamine
29 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study Completed NCT01424150 Phase 4
30 A Randomised Controlled Trial of Remifentanil Intravenous Patient Controlled Analgesia (PCA) Versus Intramuscular Pethidine for Pain Relief in Labour Completed NCT02179294 Phase 4 Pethidine;Remifentanil
31 Preserve-Transplant Study Recruiting NCT03102996 Phase 4 Nephrotrans
32 Alkalinization by Urologists & Nephrologists Recruiting NCT03035812 Phase 4 Alkali
33 Comparison of Plasmalyte A, Normal Saline and Ringer Lactate as Intraoperative Fluid During Renal Transplantation Recruiting NCT03115060 Phase 4 intravenous fluid administration WITH NORMAL SALINE, PLASMALYTE A, OR RINGER LACTATE
34 Studies of Empagliflozin and Its Cardiovascular, Renal and Metabolic Effects Recruiting NCT03485092 Phase 4 Empagliflozin 10 MG;Placebo Oral Tablet
35 DANHEART (H-HeFT and Met-HeFT) Recruiting NCT03514108 Phase 4 Hydralazine Isosorbide Dinitrate;Placebo Oral Tablet;Metformin Hydrochloride;Placebo Oral Tablet
36 Improving Glycaemic Control in Malaysian Patients With Type 2 Diabetes Mellitus With Insulin Pump Therapy Recruiting NCT03112538 Phase 4 Multiple daily injections of insulin
37 Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes Recruiting NCT03107208 Phase 4 Glargine
38 Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery Enrolling by invitation NCT02527811 Phase 4 Ulinastatin
39 Double Blinded Randomized Control Trial of Types of IVF in Children With DKA Not yet recruiting NCT03066440 Phase 4 Normal saline;Lactated Ringers
40 Changes of Gas Values in Cord Blood Versus Time and Temperature Not yet recruiting NCT02785367 Phase 4
41 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Not yet recruiting NCT03549923 Phase 4 Esmolol;Standard care
42 Lactic Acidosis During Entecavir(ETV)Treatment Terminated NCT01354652 Phase 4 entecavir, lamivudine
43 Intravenous (IV) Solutions for Dehydration in Children With Gastroenteritis Terminated NCT01234883 Phase 4 multiple electrolyte solution;saline
44 Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support Terminated NCT02414555 Phase 4 vasopressor;fluid bolus;Normal Saline;Elo-Mel Isoton (balanced acetat-based infusate)
45 Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B Terminated NCT01843309 Phase 4 Spironolactone 100mg;Spironolactone 200mg;Placebo
46 Forced Fluid Removal in High Risk Acute Kidney Injury Terminated NCT02458157 Phase 4 Furosemide (Furix)
47 Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD) Unknown status NCT01640119 Phase 3
48 Metformin Therapy for Overweight Adolescents With Type 1 Diabetes Unknown status NCT01881828 Phase 3 Metformin (glucophage)
49 Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease Completed NCT03317444 Phase 3 TRC101;Placebo
50 Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Completed NCT00004490 Phase 3 sodium dichloroacetate

Search NIH Clinical Center for Metabolic Acidosis

Genetic Tests for Metabolic Acidosis

Genetic tests related to Metabolic Acidosis:

# Genetic test Affiliating Genes
1 Metabolic Acidosis 29

Anatomical Context for Metabolic Acidosis

MalaCards organs/tissues related to Metabolic Acidosis:

41
Kidney, Heart, Brain, Lung, Bone, Liver, Testes

Publications for Metabolic Acidosis

Articles related to Metabolic Acidosis:

(show top 50) (show all 747)
# Title Authors Year
1
Recurrent Metabolic Acidosis during High-dose Midazolam Therapy for Refractory Status Epilepticus. ( 29531455 )
2018
2
Metabolic acidosis in short bowel syndrome: think D-lactic acid acidosis. ( 29769189 )
2018
3
NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. ( 29618784 )
2018
4
Metabolic acidosis and anaemia associated with dorzolamide in a patient with impaired renal function. ( 29333622 )
2018
5
Fresh red blood cells transfusion protects against aluminum phosphide-induced metabolic acidosis and mortality in rats. ( 29590163 )
2018
6
In silico identification of genes involved in chronic metabolic acidosis. ( 29138116 )
2018
7
Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease - Position Statement of the Working Group of the Polish Society of Nephrology. ( 29895022 )
2018
8
New Frontiers in Treating Uremic Metabolic Acidosis. ( 29102960 )
2018
9
Severe metabolic acidosis after out-of-hospital cardiac arrest: risk factors and association with outcome. ( 29740777 )
2018
10
Hyperkalemia in patients treated with endoradiotherapy combined with amino acid infusion is associated with severe metabolic acidosis. ( 29488080 )
2018
11
Acquired pyloric stenosis resulting in hypokalaemic, hyperchloraemic normal anion gap metabolic acidosis. Persistent vomiting in an adult: cause and effect. ( 29348282 )
2018
12
Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. ( 29915215 )
2018
13
Acute and chronic effects of metabolic acidosis on renal function and structure. ( 29700802 )
2018
14
Sodium bicarbonate on severe metabolic acidosis during prolonged cardiopulmonary resuscitation: a double-blind, randomized, placebo-controlled pilot study. ( 29850134 )
2018
15
Retinal pH and Acid Regulation During Metabolic Acidosis. ( 29641914 )
2018
16
Pseudohypoaldosteronism Type II: A Young Girl Presented with Hypertension, Hyperkalemia and Metabolic Acidosis. ( 29482694 )
2018
17
The problem of using standardised base excess as a measure of metabolic acidosis. ( 29430996 )
2018
18
Identifying newborns with umbilical cord blood metabolic acidosis by intrapartum cardiotography combined with fetal ECG ST analysis (STAN): comparison of the new and old FIGO systems to classify cardiotocograms. ( 29945485 )
2018
19
Zebrafish as a Model System for Investigating the Compensatory Regulation of Ionic Balance during Metabolic Acidosis. ( 29621145 )
2018
20
Hemodialysis during cardiopulmonary resuscitation in patients with severe metabolic acidosis. ( 29976124 )
2018
21
Impact of the hyperchloremic component of metabolic acidosis on the patient's hydration status and the treatment of diabetic ketoacidosis. ( 29756707 )
2018
22
Dietary Treatment of Metabolic Acidosis in Chronic Kidney Disease. ( 29677110 )
2018
23
FHR patterns that become significant in connection with ST waveform changes and metabolic acidosis at birth. ( 29621906 )
2018
24
Metabolic Acidosis and Subclinical Metabolic Acidosis in CKD. ( 29030467 )
2018
25
Metabolic acidosis as Food Protein Induced Enterocolitis Syndrome (FPIES) onset in a newborn. ( 29747671 )
2018
26
Metabolic acidosis and the role of unmeasured anions in critical illness and injury. ( 29506851 )
2018
27
High anion gap metabolic acidosis induced by cumulation of ketones, L- and D-lactate, 5-oxoproline and acute renal failure. ( 28749752 )
2017
28
High anion gap metabolic acidosis: A case of pyroglutamic acidosis. ( 29044962 )
2017
29
Review of the Diagnostic Evaluation of Normal Anion Gap Metabolic Acidosis. ( 29344509 )
2017
30
Impact of acute metabolic acidosis on the acid-base balance in follicular fluid and blood in dairy cattle. ( 28043369 )
2017
31
Hyperosmolar metabolic acidosis in burn patients exposed to glycol based topical antimicrobials-A systematic review. ( 28797572 )
2017
32
Topiramate and metabolic acidosis: an evolving story. ( 28828886 )
2017
33
Metabolic acidosis in hemodialysis patients: a review. ( 29044339 )
2017
34
Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication. ( 28811944 )
2017
35
Minding the Gap: Utility of the Anion Gap in the Differential Diagnosis of Metabolic Acidosis. ( 28764826 )
2017
36
Chronic Diarrhea and Metabolic Acidosis Associated With Topiramate Use. ( 28885991 )
2017
37
Management of the Metabolic Acidosis of Chronic Kidney Disease. ( 29031356 )
2017
38
Adverse Effects of the Metabolic Acidosis of Chronic Kidney Disease. ( 29031355 )
2017
39
A rare cause of metabolic acidosis: ketoacidosis in a non-diabetic lactating woman. ( 28924478 )
2017
40
Metabolic acidosis as a risk factor for the development of acute kidney injury and hospital mortality. ( 28565850 )
2017
41
Determinants and Outcome of Metabolic Acidosis in Diarrheal Children Under 5 Years of Age in an Urban Critical Care Ward in Bangladesh. ( 29152544 )
2017
42
Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease. ( 28729033 )
2017
43
Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts. ( 28934385 )
2017
44
Evaluation of the expected ventilatory response to metabolic acidosis in chronic hemodialysis patients. ( 28834137 )
2017
45
Raised Anion Gap Metabolic Acidosis in a 4-Day-Old Child. ( 28550127 )
2017
46
Fructose-1,6-bisphosphatase deficiency as aA cause of recurrent hypoglycemia and metabolic acidosis: Clinical and molecular findings in Malaysian patients. ( 29203193 )
2017
47
Metabolic acidosis of chronic kidney disease and subclinical cardiovascular disease markers: Friend or foe? ( 29381982 )
2017
48
Metabolic Acidosis or Respiratory Alkalosis? Evaluation of a Low Plasma Bicarbonate Using the Urine Anion Gap. ( 28599903 )
2017
49
Topiramate induced metabolic acidosis and kidney stones - a case study. ( 28694730 )
2017
50
Assessment of resuscitation as measured by markers of metabolic acidosis and features of injury. ( 28053267 )
2017

Variations for Metabolic Acidosis

Expression for Metabolic Acidosis

Search GEO for disease gene expression data for Metabolic Acidosis.

Pathways for Metabolic Acidosis

Pathways related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 ALB ATP6V0A4 ATP6V1B1 CA2 FBP1 GLS2
2
Show member pathways
12.74 ALB AQP2 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4
3 12.22 AQP2 CA2 FBP1 SLC4A4
4
Show member pathways
12.11 ATP6V0A4 ATP6V1B1 CA2 SLC4A1
5 11.56 CA2 SLC4A4 SLC9A1
6 11.46 GSS HMGCL OGDH
7 11.31 CA2 SLC4A4 SLC9A1 SLC9A3
8 10.29 CA2 GLS2 SLC4A4 SLC9A3

GO Terms for Metabolic Acidosis

Cellular components related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 ALB AQP2 ATP6V0A4 ATP6V1B1 CA2 FBP1
2 mitochondrial matrix GO:0005759 9.62 GLS2 HMGCL MLYCD OGDH
3 apical plasma membrane GO:0016324 9.55 AQP2 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
4 vacuolar proton-transporting V-type ATPase complex GO:0016471 9.26 ATP6V0A4 ATP6V1B1
5 basolateral plasma membrane GO:0016323 9.1 AQP2 ATP6V1B1 CA2 SLC4A1 SLC4A4 SLC9A1

Biological processes related to Metabolic Acidosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.7 ATP6V0A4 ATP6V1B1 SLC4A1 SLC4A4 SLC9A1 SLC9A3
2 sodium ion transport GO:0006814 9.69 SLC4A4 SLC9A1 SLC9A3
3 ossification GO:0001503 9.65 ATP6V0A4 ATP6V1B1 BGLAP
4 bicarbonate transport GO:0015701 9.61 CA2 SLC4A1 SLC4A4
5 proton transmembrane transport GO:1902600 9.56 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
6 excretion GO:0007588 9.54 AQP2 ATP6V0A4 ATP6V1B1
7 phagosome acidification GO:0090383 9.52 ATP6V0A4 ATP6V1B1
8 sodium ion import across plasma membrane GO:0098719 9.49 SLC9A1 SLC9A3
9 ion homeostasis GO:0050801 9.46 KLHL3 WNK4
10 renal sodium ion absorption GO:0070294 9.4 KLHL3 WNK4
11 distal tubule morphogenesis GO:0072156 9.32 KLHL3 WNK4
12 regulation of pH GO:0006885 9.26 ATP6V0A4 ATP6V1B1 SLC9A1 SLC9A3
13 regulation of intracellular pH GO:0051453 9.02 CA2 SLC4A1 SLC4A4 SLC9A1 SLC9A3

Molecular functions related to Metabolic Acidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 9.54 CA2 HMGCL MLYCD
2 anion transmembrane transporter activity GO:0008509 9.32 SLC4A1 SLC4A4
3 solute:proton antiporter activity GO:0015299 9.26 SLC9A1 SLC9A3
4 sodium:proton antiporter activity GO:0015385 9.16 SLC9A1 SLC9A3
5 potassium:proton antiporter activity GO:0015386 8.96 SLC9A1 SLC9A3
6 sodium:bicarbonate symporter activity GO:0008510 8.62 SLC4A1 SLC4A4

Sources for Metabolic Acidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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