MF4
MCID: MTC100
MIFTS: 19
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Metacarpal 4-5 Fusion (MF4)
Categories:
Bone diseases, Fetal diseases, Genetic diseases, Rare diseases
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MalaCards integrated aliases for Metacarpal 4-5 Fusion:
Characteristics:Orphanet epidemiological data:59
syndactyly type 8
Inheritance: Autosomal dominant,X-linked recessive; HPO:32Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases Anatomical: Bone diseases
ICD10:
34
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NIH Rare Diseases
:
53
The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 2498Disease definitionSyndactyly type 8 is a rare, genetic, non-syndromic, congenital limb malformation characterized by unilateral or bilateral fusion of the fourth and fifth metacarpals with no other associated abnomalities. Patients present shortened fourth and fifth metacarpals with excessive separation between their distal ends, resulting in marked ulnar deviation of the little finger and an inability to bring the fifth finger in parallel with the other fingers.Visit the Orphanet disease page for more resources.
MalaCards based summary : Metacarpal 4-5 Fusion, is also known as mf4. An important gene associated with Metacarpal 4-5 Fusion is FGF16 (Fibroblast Growth Factor 16). The drug Ivacaftor has been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is fused fourth and fifth metacarpals. UniProtKB/Swiss-Prot : 75 Metacarpal 4-5 fusion: A rare congenital malformation of the hand characterized by the partial or complete fusion of the fourth and fifth metacarpals. The anomaly occurs as an isolated trait or part of a syndrome.
Description from OMIM:
309630
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Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:309630Human phenotypes related to Metacarpal 4-5 Fusion:59 32
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Drugs for Metacarpal 4-5 Fusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:
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MalaCards organs/tissues related to Metacarpal 4-5 Fusion:41
Bone
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Articles related to Metacarpal 4-5 Fusion:
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UniProtKB/Swiss-Prot genetic disease variations for Metacarpal 4-5 Fusion:75
ClinVar genetic disease variations for Metacarpal 4-5 Fusion:6
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Search
GEO
for disease gene expression data for Metacarpal 4-5 Fusion.
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