MCID: MTL005
MIFTS: 36

Metal Allergy

Categories: Immune diseases

Aliases & Classifications for Metal Allergy

MalaCards integrated aliases for Metal Allergy:

Name: Metal Allergy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060501
UMLS 73 C0577627

Summaries for Metal Allergy

Disease Ontology : 12 A hypersensitivity reaction type I disease triggered by a metal.

MalaCards based summary : Metal Allergy is related to dermatitis and limbic encephalitis with lgi1 antibodies. An important gene associated with Metal Allergy is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and TCR Signaling (Qiagen). The drugs Cobalt and Molybdenum have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and skin.

Related Diseases for Metal Allergy

Diseases related to Metal Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 dermatitis 10.2
2 limbic encephalitis with lgi1 antibodies 10.1 HLA-DQB1 HLA-DRB1
3 narcolepsy 2 10.1 HLA-DQB1 HLA-DRB1
4 autoimmune polyglandular syndrome type 3 10.1 HLA-DQB1 HLA-DRB1
5 hypersomnia 10.1 HLA-DQB1 HLA-DRB1
6 lichen planopilaris 10.1 HLA-DQB1 HLA-DRB1
7 type ii mixed cryoglobulinemia 10.1 HLA-DQB1 HLA-DRB1
8 beryllium disease 10.1 HLA-DQB1 HLA-DRB1
9 recurrent respiratory papillomatosis 10.1 HLA-DQB1 HLA-DRB1
10 narcolepsy 1 10.1 HLA-DQB1 HLA-DRB1
11 chronic beryllium disease 10.1 HLA-DQB1 HLA-DRB1
12 lichen sclerosus 10.1 HLA-DQB1 HLA-DRB1
13 whipple disease 10.1 HLA-DQB1 HLA-DRB1
14 pityriasis rosea 10.1 HLA-DQB1 HLA-DRB1
15 pediatric multiple sclerosis 10.1 HLA-DQB1 HLA-DRB1
16 microscopic colitis 10.1 HLA-DQB1 HLA-DRB1
17 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
18 idiopathic bronchiectasis 10.1 HLA-DQB1 HLA-DRB1
19 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
20 acute disseminated encephalomyelitis 10.1 HLA-DQB1 HLA-DRB1
21 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
22 glaucomatocyclitic crisis 10.1 HLA-DQB1 HLA-DRB1
23 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
24 panuveitis 10.1 HLA-DQB1 HLA-DRB1
25 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
26 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
27 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
28 vogt-koyanagi-harada disease 10.0 HLA-DQB1 HLA-DRB1
29 rubella 10.0 HLA-DQB1 HLA-DRB1
30 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1
31 bone inflammation disease 10.0 HLA-DRB1 TBXAS1
32 autoimmune hepatitis 10.0 HLA-DQB1 HLA-DRB1
33 pectus excavatum 10.0
34 thrombosis 10.0
35 lichen planus 10.0
36 cerebral aneurysms 10.0
37 alveolar echinococcosis 10.0 CD8A HLA-DRB1
38 polyclonal hypergammaglobulinemia 9.9 CD4 CD8A
39 bullous pemphigoid 9.9 HLA-DQB1 HLA-DRB1
40 thymus lipoma 9.9 CD4 CD8A
41 immune system organ benign neoplasm 9.9 CD4 CD8A
42 xanthogranulomatous cholecystitis 9.9 CD4 CD8A
43 melkersson-rosenthal syndrome 9.9 CD4 CD8A
44 leishmaniasis 9.9 HLA-DQB1 HLA-DRB1
45 systemic lupus erythematosus 9.8
46 thrombocytopenia 9.8
47 scoliosis 9.8
48 hypohidrosis 9.8
49 allergic hypersensitivity disease 9.8
50 protein s deficiency 9.8

Graphical network of the top 20 diseases related to Metal Allergy:



Diseases related to Metal Allergy

Symptoms & Phenotypes for Metal Allergy

Drugs & Therapeutics for Metal Allergy

Drugs for Metal Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobalt Approved, Experimental Not Applicable 7440-48-4 104729
2
Molybdenum Approved Not Applicable 7439-98-7 185498
3
Chromium Approved Not Applicable 7440-47-3 27668
4 Antibiotics, Antitubercular Not Applicable
5 Anti-Bacterial Agents Not Applicable
6
Nickel Not Applicable 7440-02-0 934

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Metal Skin Sensitivity on Restenosis After Stent Implantation Unknown status NCT00226525 Not Applicable
2 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
3 Cutaneous and Systemic Reactions to Metal Implants Recruiting NCT02483728 Not Applicable
4 Metal Allergy In-Stent Restenosis Study Not yet recruiting NCT03588962 Not Applicable

Search NIH Clinical Center for Metal Allergy

Genetic Tests for Metal Allergy

Anatomical Context for Metal Allergy

MalaCards organs/tissues related to Metal Allergy:

41
Testes, Heart, Skin, Eye, Bone, Tongue, Thymus

Publications for Metal Allergy

Articles related to Metal Allergy:

(show top 50) (show all 82)
# Title Authors Year
1
Metal allergy as a late-onset complication of the Nuss procedure in a pediatric patient. ( 29897675 )
2018
2
Outcomes of Revision Joint Arthroplasty Due to Metal Allergy and Hypersensitivity: A Systematic Review. ( 29985516 )
2018
3
What role does metal allergy sensitization play in total knee arthroplasty revision? ( 30109436 )
2018
4
Metal allergy in total-joint arthroplasty: Case report and literature review. ( 30235744 )
2018
5
Metal allergy patient treated by titanium implant denture: A case report with at least 4-year follow-up. ( 30349710 )
2018
6
Pipeline Treatment of Intracranial Aneurysms is Safe and Effective in Patients with Cutaneous Metal Allergy. ( 30476671 )
2018
7
Metal Allergy as a Cause of Implant Failure in Shoulder Arthroplasty. ( 28776630 )
2017
8
Selective versus routine patch metal allergy testing to select bar material for the Nuss procedure in 932 patients over 10years. ( 29223667 )
2017
9
Making Sense of Metal Allergy and Hypersensitivity to Metallic Implants in Relation to Hand Surgery. ( 28709788 )
2017
10
Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus. ( 28342246 )
2017
11
Dyshidrotic Eczema and Its Relationship to Metal Allergy. ( 27584966 )
2016
12
Patient-Reported Metal Allergy: A Risk Factor for Poor Outcomes After Total Joint Arthroplasty? ( 26965589 )
2016
13
Influence of Surface Coating on Metal Ion Release: Evaluation in Patients With Metal Allergy. ( 27219723 )
2016
14
Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice. ( 27240418 )
2016
15
Metal allergy to everolimus-eluting cobalt chromium stents confirmed by positive skin testing as a cause of recurrent multivessel in-stent restenosis. ( 26011018 )
2016
16
Metal allergy in eyelid dermatitis and the evaluation of metal contents in eye shadows. ( 27004926 )
2016
17
Diagnosis of metal allergy and management of oral lichenoid reactions. ( 26332591 )
2016
18
Metal allergy after first metatarsophalangeal total joint replacement--Case report. ( 26235863 )
2015
19
Stent thrombosis caused by metal allergy complicated by protein S deficiency and heparin-induced thrombocytopenia: a case report and review of the literature. ( 26207097 )
2015
20
Patch Testing for Metal Allergy With Manufacturer-Supplied Materials Before Nuss Bar Insertion. ( 26551606 )
2015
21
Dermatitis caused by metal allergy after coil embolization for unruptured cerebral aneurysm. ( 26553880 )
2015
22
The association between metal allergy, total knee arthroplasty, and revision: study based on the Danish Knee Arthroplasty Register. ( 25582229 )
2015
23
Prevalence of self-reported metal allergy in patients undergoing primary total knee arthroplasty. ( 24949984 )
2015
24
Dermatitis caused by metal allergy after coil embolization for unruptured cerebral aneurysm. ( 26531730 )
2015
25
High rates of metal allergy amongst Nuss procedure patients dictate broader pre-operative testing. ( 24650476 )
2014
26
Metal release and metal allergy after total hip replacement with resurfacing versus conventional hybrid prosthesis. ( 24930546 )
2014
27
Novel indication for bioabsorbable scaffolds in metal allergy. ( 24333740 )
2014
28
Novel metal allergy patch test using metal nanoballs. ( 25467761 )
2014
29
A prospective study concerning the relationship between metal allergy and post-operative pain following total hip and knee arthroplasty. ( 24910214 )
2014
30
Prospective analysis of the incidence of metal allergy in patients listed for total replacement of the temporomandibular joint. ( 23850381 )
2014
31
Metal allergy to titanium bars after the Nuss procedure for pectus excavatum. ( 25087797 )
2014
32
Carbon Coated Implants as a New Solution for Metal Allergy in Early-Onset Scoliosis: A Case Report and Review of the Literature. ( 27927446 )
2014
33
Metal allergy screening prior to joint arthroplasty and its influence on implant choice: a delphi consensus study amongst orthopaedic arthroplasty surgeons. ( 24368996 )
2013
34
Close association between metal allergy and nail lichen planus: detection of causative metals in nail lesions. ( 22564023 )
2013
35
Metal allergy in patients with total hip replacement: a review. ( 23569024 )
2013
36
Characterization of T cell receptors of Th1 cells infiltrating inflamed skin of a novel murine model of palladium-induced metal allergy. ( 24098486 )
2013
37
Stent implantation in patients with metal allergy: a systemic review and meta-analysis. ( 24135817 )
2013
38
Metal allergy and systemic contact dermatitis: an overview. ( 22693488 )
2012
39
Metal allergy and second-generation metal-on-metal arthroplasties. ( 21957973 )
2012
40
Outcomes after coronary stent implantation in patients with metal allergy. ( 22456027 )
2012
41
Titanium alloy removable partial denture framework in a patient with a metal allergy: a case study. ( 22878308 )
2012
42
No association between metal allergy and cardiac in-stent restenosis in patients with dermatitis-results from a linkage study. ( 21226719 )
2011
43
Cross-reactivity among some metals in a murine metal allergy model. ( 21692768 )
2011
44
Correlation between metal allergy and treatment outcomes after ankle fracture fixation. ( 22184160 )
2011
45
Revision of a tibial baseplate using a customized oxinium component in a case of suspected metal allergy. A case report. ( 22187849 )
2011
46
Absence of metal allergy in patients with very late drug-eluting stent thrombosis: a pilot study. ( 20965590 )
2010
47
Metal allergy, atrial septal occluder devices and the risk of Kounis syndrome. ( 21095381 )
2010
48
Applicability of zirconia dental prostheses for metal allergy patients. ( 21209994 )
2010
49
Metal allergy--a review on exposures, penetration, genetics, prevalence, and clinical implications. ( 19831422 )
2010
50
Metal allergy to Amplatzer occluder device presented as severe bronchospasm. ( 19932286 )
2009

Variations for Metal Allergy

Expression for Metal Allergy

Search GEO for disease gene expression data for Metal Allergy.

Pathways for Metal Allergy

Pathways related to Metal Allergy according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.1 CD4 CD8A HLA-DQB1 HLA-DRB1
2
Show member pathways
12.56 CD4 CD8A HLA-DQB1 HLA-DRB1
3
Show member pathways
12.5 CD4 CD8A HLA-DQB1 HLA-DRB1
4
Show member pathways
12.32 CD4 HLA-DQB1 HLA-DRB1
5
Show member pathways
12.29 CD4 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.09 CD4 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.05 CD4 HLA-DQB1 HLA-DRB1
8
Show member pathways
11.91 CD4 HLA-DQB1 HLA-DRB1
9 11.7 CD4 CD8A
10
Show member pathways
11.65 CD4 HLA-DQB1 HLA-DRB1
11 11.64 HLA-DQB1 HLA-DRB1
12
Show member pathways
11.63 CD4 CD8A HLA-DRB1
13 11.62 CD4 CD8A HLA-DQB1 HLA-DRB1
14 11.59 CD4 HLA-DQB1 HLA-DRB1
15 11.58 HLA-DQB1 HLA-DRB1
16
Show member pathways
11.58 CD4 HLA-DQB1 HLA-DRB1
17
Show member pathways
11.53 CD4 CD8A HLA-DRB1
18 11.51 CD4 CD8A
19 11.49 CD4 HLA-DRB1
20 11.47 CD4 CD8A
21 11.34 HLA-DQB1 HLA-DRB1
22 11.24 CD4 CD8A HLA-DQB1 HLA-DRB1
23 11.16 CD4 CD8A HLA-DQB1 HLA-DRB1
24 11.14 CD4 CD8A
25 11.02 CD4 HLA-DRB1
26 10.99 CD4 HLA-DRB1
27 10.78 CD4 CD8A HLA-DQB1 HLA-DRB1

GO Terms for Metal Allergy

Cellular components related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.54 CD4 CD8A HLA-DRB1
2 cell GO:0005623 9.48 PROK2 TBXAS1
3 trans-Golgi network membrane GO:0032588 9.46 HLA-DQB1 HLA-DRB1
4 endocytic vesicle membrane GO:0030666 9.43 HLA-DQB1 HLA-DRB1
5 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DQB1 HLA-DRB1
6 transport vesicle membrane GO:0030658 9.32 HLA-DQB1 HLA-DRB1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DQB1 HLA-DRB1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DQB1 HLA-DRB1
9 MHC class II protein complex GO:0042613 8.96 HLA-DQB1 HLA-DRB1
10 T cell receptor complex GO:0042101 8.62 CD4 CD8A

Biological processes related to Metal Allergy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 CD4 CD8A HLA-DRB1
2 immune response GO:0006955 9.56 CD4 CD8A HLA-DQB1 HLA-DRB1
3 T cell receptor signaling pathway GO:0050852 9.5 CD4 HLA-DQB1 HLA-DRB1
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.48 CD4 CD8A
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.46 HLA-DQB1 HLA-DRB1
6 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DQB1 HLA-DRB1
7 T cell activation GO:0042110 9.4 CD4 CD8A
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.37 HLA-DQB1 HLA-DRB1
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
10 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1
11 antigen processing and presentation GO:0019882 8.8 CD8A HLA-DQB1 HLA-DRB1

Molecular functions related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.26 CD4 HLA-DRB1
2 coreceptor activity GO:0015026 9.16 CD4 CD8A
3 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
4 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Metal Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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