MCID: MTL005
MIFTS: 39

Metal Allergy

Categories: Immune diseases

Aliases & Classifications for Metal Allergy

MalaCards integrated aliases for Metal Allergy:

Name: Metal Allergy 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060501
UMLS 70 C0577627

Summaries for Metal Allergy

Disease Ontology : 12 An allergic disease that is triggered by a metal.

MalaCards based summary : Metal Allergy is related to allergic contact dermatitis and exanthem. An important gene associated with Metal Allergy is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Chromium and Molybdenum have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are hematopoietic system and immune system

Related Diseases for Metal Allergy

Diseases related to Metal Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 546)
# Related Disease Score Top Affiliating Genes
1 allergic contact dermatitis 29.9 IL4 IL17A IL10 CD4
2 exanthem 29.8 IL2 IL10 CD8A CD4
3 allergic disease 29.8 TLR4 IL4 IL2 IL10
4 lichen planus 29.7 IL4 IL2 IL17A IL10
5 periapical periodontitis 29.6 IL17A IL10
6 urticaria 29.4 IL4 IL10 CD4
7 gastritis 29.4 TLR4 IL17A IL10
8 dermatitis 29.4 IL4 IL2 IL17A IL10 CD8A CD4
9 stomatitis 29.3 IL4 IL2 IL10 CD4
10 contact dermatitis 29.2 TLR4 IL4 IL2 IL17A IL10 CD4
11 chronic fatigue syndrome 28.6 TLR4 IL4 IL2 IL17A IL10
12 periodontitis 28.6 TLR4 IL4 IL2 IL17A IL10
13 thrombocytopenia 28.6 TLR4 IL4 IL2 IL17A IL10
14 alopecia areata 28.6 IL4 IL2 IL17A IL10 HLA-DRB1 HLA-DQB1
15 skin disease 28.4 IL4 IL2 IL17A IL10 CD8A CD4
16 dermatitis, atopic 28.4 TLR4 IL4 IL2 IL17A IL10 CD8A
17 systemic lupus erythematosus 27.8 TLR4 IL4 IL2 IL17A IL10 HLA-DRB1
18 limbic encephalitis with lgi1 antibodies 10.4 HLA-DRB1 HLA-DQB1
19 autoimmune polyglandular syndrome type 3 10.4 HLA-DRB1 HLA-DQB1
20 idiopathic hypersomnia 10.4 HLA-DRB1 HLA-DQB1
21 hypersomnia 10.4 HLA-DRB1 HLA-DQB1
22 narcolepsy 2 10.4 HLA-DRB1 HLA-DQB1
23 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-DRB1 HLA-DQB1
24 latent autoimmune diabetes in adults 10.4 HLA-DRB1 HLA-DQB1
25 occupational asthma 10.4 HLA-DRB1 HLA-DQB1
26 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQB1
27 beryllium disease 10.3 HLA-DRB1 HLA-DQB1
28 apple allergy 10.3 HLA-DRB1 HLA-DQB1
29 chronic beryllium disease 10.3 HLA-DRB1 HLA-DQB1
30 focal epithelial hyperplasia 10.3 HLA-DRB1 HLA-DQB1
31 pediatric multiple sclerosis 10.3 HLA-DRB1 HLA-DQB1
32 podoconiosis 10.3 HLA-DRB1 HLA-DQB1
33 caplan's syndrome 10.3 HLA-DRB1 CD4
34 pityriasis rosea 10.3 HLA-DRB1 HLA-DQB1
35 narcolepsy 1 10.3 HLA-DRB1 HLA-DQB1
36 cork-handlers' disease 10.3 CD8A CD4
37 necrotic uveal melanoma 10.3 CD8A CD4
38 early yaws 10.3 CD8A CD4
39 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DRB1 HLA-DQB1
40 ventilation pneumonitis 10.3 CD8A CD4
41 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
42 latent syphilis 10.3 CD8A CD4
43 type 1 diabetes mellitus 23 10.3 CD8A CD4
44 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
45 parapsoriasis 10.3 CD8A CD4
46 gastroduodenitis 10.3 CD8A CD4
47 duodenitis 10.3 CD8A CD4
48 primary syphilis 10.3 CD8A CD4
49 bird fancier's lung 10.3 CD8A CD4
50 variola major 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Metal Allergy:



Diseases related to Metal Allergy

Symptoms & Phenotypes for Metal Allergy

MGI Mouse Phenotypes related to Metal Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CD4 CD8A HDC HLA-DQB1 IL10 IL17A
2 immune system MP:0005387 9.96 CD4 CD8A HDC HLA-DQB1 IL10 IL17A
3 digestive/alimentary MP:0005381 9.95 CD4 HLA-DQB1 IL10 IL17A IL2 IL4
4 endocrine/exocrine gland MP:0005379 9.91 CD4 CD8A HLA-DQB1 IL10 IL17A IL2
5 integument MP:0010771 9.76 CD4 CD8A HDC IL10 IL17A IL4
6 no phenotypic analysis MP:0003012 9.43 CD4 HDC IL10 IL17A IL2 IL4
7 respiratory system MP:0005388 9.1 HLA-DQB1 IL10 IL17A IL2 IL4 TLR4

Drugs & Therapeutics for Metal Allergy

Drugs for Metal Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chromium Approved 7440-47-3 27668
2
Molybdenum Approved 7439-98-7 185498
3
Cobalt Approved, Experimental 7440-48-4 104729
4
Petrolatum Approved, Investigational 8009-03-8
5 Trace Elements
6 Nutrients
7
Nickel 7440-02-0 934
8 Micronutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 RESTenosis in Patients With Contact ALLergy to Metals Zabrze Study Unknown status NCT03588962
2 The Immunological Profile of Nickel Dermatitis Recruiting NCT04438330

Search NIH Clinical Center for Metal Allergy

Genetic Tests for Metal Allergy

Anatomical Context for Metal Allergy

MalaCards organs/tissues related to Metal Allergy:

40
Skin, T Cells, Bone Marrow, Eye, Breast

Publications for Metal Allergy

Articles related to Metal Allergy:

(show top 50) (show all 333)
# Title Authors PMID Year
1
Pulmonary arteriovenous malformation with metal allergy. 61
33692060 2021
2
Prevalence, concomitant reactions, and factors associated with fragrance allergy in Thailand. 61
33075139 2021
3
Similar rates of return to sports and BMI reduction regardless of age, gender and preoperative BMI as seen in matched cohort of hypoallergenic and standard Cobalt Chromium medial unicompartmental knee arthroplasty. 61
33550449 2021
4
The role of metal patch testing in evaluating patients for metallic prosthetic joint failure. 61
33639260 2021
5
Memory T helper cells identify patients with nickel, cobalt, and chromium metal allergy. 61
33576045 2021
6
Suspected Metal Allergy and Femoral Loosening After Total Knee Arthroplasty: A Diagnostic Dilemma. 61
33521207 2021
7
Titanium Niobium Nitride Mobile-Bearing Unicompartmental Knee Arthroplasty Results in Good to Excellent Clinical and Radiographic Outcomes in Metal Allergy Patients With Medial Knee Osteoarthritis. 61
32773267 2021
8
Case series of metal allergy following Nuss procedure not only for stainless steel bars. 61
33487461 2021
9
Fatigue behaviour of dental crowns made from a novel high-performance polymer PEKK. 61
33506428 2021
10
Metal allergy after the Nuss procedure for pectus excavatum: a review. 61
33603601 2020
11
Early Outcomes of an Alternative Bearing Surface in Primary Total Knee Arthroplasty in Patients with Self-reported Metal Allergy. 61
32875011 2020
12
Morbidity After Metal Allergy to a Total Ankle Implant. 61
32840132 2020
13
Arthroscopic Superior Capsule Reconstruction for Cuff Tear Arthropathy (Hamada Grade 5): A Case Report. 61
33449542 2020
14
Low Rate of Complications Following Intramedullary Headless Compression Screw Fixation of Metacarpal Fractures. 61
30894028 2020
15
Clinical factors before or after device implantation in predicting metal hypersensitivity reactions: A retrospective study. 61
32533849 2020
16
Titanium salts tested in reconstructed human skin with integrated MUTZ-3-derived Langerhans cells show an irritant rather than a sensitizing potential. 61
32677096 2020
17
Patch Testing With an Extended Metal Allergen Series at the Massachusetts General Hospital (2006-2017). 61
32520762 2020
18
Decrease of Quality of Life, Functional Assessment and Associated Psychological Distress in Patients with Hypoallergenic Total Knee Arthroplasty. 61
33053865 2020
19
Ten-year outcomes of a nitrided Ti-6Al-4V titanium alloy fixed-bearing total knee replacement with a highly crosslinked polyethylene-bearing in patients with metal allergy. 61
33010769 2020
20
[Mitral Valve Plasty in a Patient with Multiple Metal Allergy;Report of a Case]. 61
33130721 2020
21
New insights on metal allergy in total joint arthroplasty. 61
33739017 2020
22
Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. 61
32884021 2020
23
Rate of actual metal allergy prior to dental treatment in subjects complaining of possible metal allergy. 61
30903995 2020
24
Adverse Reaction to Zirconia in a Modern Total Hip Arthroplasty with Ceramic Head. 61
32995410 2020
25
The risk factors for occupational contact dermatitis among workers in a medium density fiberboard furniture factory in Eastern Thailand. 61
32924862 2020
26
Metals in used and unused metalworking fluids: X-ray fluorescence spectrometry as a screening test. 61
32212165 2020
27
Nickel allergy to orthopaedic implants: A review and case series. 61
32774035 2020
28
Non-heat inactivated autologous serum increases accuracy of in vitro CFSE lymphocyte proliferation test (LPT) for nickel. 61
32215995 2020
29
Cross-Reactivity of Palladium in a Murine Model of Metal-Induced Allergic Contact Dermatitis. 61
32517103 2020
30
Does Metal Hypersensitivity Have Relevance in Patients Undergoing TMJ Prosthetic Replacement? 61
32087119 2020
31
Remission of Palmoplantar Pustulosis after On-Pump Coronary Artery Bypass Grafting in a Patient with Titanium Allergy. 61
29681595 2020
32
Effects of UV Treatment on Ceria-Stabilized Zirconia/Alumina Nanocomposite (NANOZR). 61
32570895 2020
33
Methylchloroisothiazolinone and/or Methylisothiazolinone Contact Allergies in Thailand. 61
32209866 2020
34
Pediatric lichen planus pigmentosus possibly triggered by mercury dental amalgams. 61
31876002 2020
35
Revision temporomandibular joint arthroplasty for the treatment of acquired metal allergy and review of the literature. 61
31447220 2020
36
The effect of patient-reported metal allergies on the outcomes of shoulder arthroplasty. 61
31427231 2020
37
Hypersensitivity reactions to orthopedic implants: what's all the hype? 61
32186530 2020
38
Oral Implant Treatment for a Patient Undergoing Molecularly Targeted Drug Therapy for Chronic Myelocytic Leukemia: A Case Report. 61
31860921 2020
39
[COPING STRATEGY OF METAL ALLERGY-MAINLY ABOUT SYSTEMIC METAL ALLERGY]. 61
32435017 2020
40
Allergic contact dermatitis in atopic individuals: Results of a 30-year retrospective study. 61
31347185 2019
41
Could a Titanium Ulnar Shortening Plate Trigger a Metal Allergy? A Case Report. 61
31815066 2019
42
Effects of magnetic fields from electric toothbrushes on fluoride- and oral bacteria-induced corrosion of orthodontic metallic wires. 61
31366769 2019
43
Self-Reported Metal Allergy and Early Outcomes After Total Knee Arthroplasty. 61
31505017 2019
44
Utility of Patch Testing and Lymphocyte Transformation Testing in the Evaluation of Metal Allergy in Patients with Orthopedic Implants. 61
31723520 2019
45
Platinum and palladium nanoparticle-containing mixture, PAPLAL, does not induce palladium allergy. 61
31260134 2019
46
Cytokine Profile in Patients with Aseptic Loosening of Total Hip Replacements and Its Relation to Metal Release and Metal Allergy. 61
31434199 2019
47
Analysis of nickel distribution by synchrotron radiation X-ray fluorescence in nickel-induced early- and late-phase allergic contact dermatitis in Hartley guinea pigs. 61
31373908 2019
48
COX-2 induces T cell accumulation and IFN-γ production during the development of chromium allergy. 61
31587584 2019
49
Current status of dental metal allergy in Japan. 61
30738702 2019
50
Microdeformational wound therapy: A novel option to salvage complex wounds associated with the Nuss procedure. 61
30967247 2019

Variations for Metal Allergy

Expression for Metal Allergy

Search GEO for disease gene expression data for Metal Allergy.

Pathways for Metal Allergy

Pathways related to Metal Allergy according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TLR4 IL4 IL2 IL17A IL10 HLA-DRB1
2
Show member pathways
13.27 TLR4 IL4 IL2 IL17A IL10 CD4
3
Show member pathways
13.25 IL4 IL2 IL17A IL10 HLA-DRB1 HLA-DQB1
4
Show member pathways
13.07 TLR4 IL4 IL2 HLA-DRB1 HLA-DQB1
5
Show member pathways
12.69 TLR4 IL2 HLA-DRB1 HLA-DQB1
6
Show member pathways
12.6 IL4 IL2 IL17A IL10 HLA-DRB1 HLA-DQB1
7
Show member pathways
12.54 IL4 IL2 IL10 HLA-DRB1 HLA-DQB1 CD4
8 12.49 IL4 IL2 IL17A IL10 CD8A
9
Show member pathways
12.48 IL2 IL17A IL10 CD4
10
Show member pathways
12.41 TLR4 IL4 IL2 IL17A IL10 CD8A
11
Show member pathways
12.31 IL2 HLA-DRB1 HLA-DQB1 CD4
12 12.27 IL2 HLA-DRB1 HLA-DQB1 CD4
13
Show member pathways
12.2 TLR4 IL4 IL10 HLA-DRB1 HLA-DQB1
14
Show member pathways
12.17 IL4 IL2 IL17A IL10
15 12.17 TLR4 IL10 HLA-DRB1 HLA-DQB1
16
Show member pathways
12.1 HLA-DRB1 HLA-DQB1 CD4
17 12.08 HLA-DRB1 HLA-DQB1 CD8A CD4
18 12.03 TLR4 HLA-DRB1 HLA-DQB1
19 12.01 TLR4 IL2 IL10 CD8A CD4
20 11.92 TLR4 IL4 IL2
21 11.92 IL4 IL2 IL10 CD8A CD4
22 11.9 IL4 IL17A IL10
23
Show member pathways
11.88 HLA-DRB1 HLA-DQB1 CD4
24
Show member pathways
11.88 IL4 IL2 HLA-DRB1 CD8A CD4
25
Show member pathways
11.87 HLA-DRB1 CD8A CD4
26 11.84 TLR4 IL17A HLA-DRB1 HLA-DQB1
27 11.83 HLA-DRB1 HLA-DQB1 CD4
28
Show member pathways
11.82 TLR4 IL4 IL17A CD4
29 11.8 IL10 HLA-DRB1 HLA-DQB1
30 11.8 IL4 HLA-DRB1 HLA-DQB1 CD8A CD4
31
Show member pathways
11.76 TLR4 IL4 IL2 IL17A IL10 HLA-DRB1
32
Show member pathways
11.75 HLA-DRB1 HLA-DQB1 CD4
33 11.72 IL2 IL10 CD8A CD4
34 11.69 HLA-DRB1 HLA-DQB1 CD8A CD4
35
Show member pathways
11.65 TLR4 IL2 IL17A IL10 CD4
36 11.63 TLR4 IL4 IL10
37 11.46 IL4 IL2 IL10 CD4
38 11.34 IL4 IL2 IL17A IL10 CD8A CD4
39 11.22 IL2 HLA-DRB1 CD4
40 11.17 IL4 IL2 IL10
41 11.02 IL4 IL2 IL10 HLA-DRB1 CD4

GO Terms for Metal Allergy

Cellular components related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 TLR4 IL17A HLA-DRB1 CD8A CD4
2 MHC class II protein complex GO:0042613 8.96 HLA-DRB1 HLA-DQB1

Biological processes related to Metal Allergy according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.84 HLA-DRB1 HLA-DQB1 CD4
2 negative regulation of inflammatory response GO:0050728 9.81 IL4 IL2 IL10
3 defense response to Gram-negative bacterium GO:0050829 9.76 TLR4 IL17A CD4
4 negative regulation of tumor necrosis factor production GO:0032720 9.75 TLR4 IL4 IL10
5 positive regulation of kinase activity GO:0033674 9.74 IL2 HLA-DRB1 CD4
6 adaptive immune response GO:0002250 9.73 IL2 IL17A HLA-DRB1 HLA-DQB1 CD8A CD4
7 positive regulation of T cell proliferation GO:0042102 9.72 IL4 IL2 CD4
8 cytokine-mediated signaling pathway GO:0019221 9.72 IL4 IL2 IL17A IL10 CD4
9 T cell activation GO:0042110 9.69 IL4 CD8A CD4
10 antigen processing and presentation GO:0019882 9.67 HLA-DRB1 HLA-DQB1 CD8A
11 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.66 TLR4 IL17A
12 negative regulation of osteoclast differentiation GO:0045671 9.65 TLR4 IL4
13 macrophage differentiation GO:0030225 9.65 HLA-DRB1 CD4
14 positive regulation of T cell differentiation GO:0045582 9.65 IL4 IL2
15 negative regulation of interferon-gamma production GO:0032689 9.65 TLR4 IL10 HLA-DRB1
16 positive regulation of macrophage activation GO:0043032 9.64 TLR4 IL10
17 positive regulation of immunoglobulin production GO:0002639 9.64 IL2 IL10
18 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.63 HLA-DRB1 HLA-DQB1
19 macrophage activation GO:0042116 9.62 TLR4 IL4
20 positive regulation of viral entry into host cell GO:0046598 9.62 HLA-DRB1 CD4
21 positive regulation of monocyte differentiation GO:0045657 9.61 HLA-DRB1 CD4
22 T-helper 1 type immune response GO:0042088 9.61 TLR4 HLA-DRB1
23 negative regulation of T-helper 17 cell differentiation GO:2000320 9.6 IL4 IL2
24 positive regulation of isotype switching to IgG isotypes GO:0048304 9.59 IL4 IL2
25 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.56 HLA-DRB1 HLA-DQB1
26 intestinal epithelial structure maintenance GO:0060729 9.54 TLR4 IL17A
27 positive regulation of B cell proliferation GO:0030890 9.54 TLR4 IL4 IL2
28 type 2 immune response GO:0042092 9.52 IL4 IL10
29 immune system process GO:0002376 9.5 TLR4 IL2 IL17A HLA-DRB1 HLA-DQB1 CD8A
30 positive regulation of plasma cell differentiation GO:1900100 9.46 IL2 IL10
31 regulation of isotype switching GO:0045191 9.43 IL4 IL10
32 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DRB1 HLA-DQB1
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.33 TLR4 IL4 IL10
34 immune response GO:0006955 9.28 TLR4 IL4 IL2 IL17A IL10 HLA-DRB1

Molecular functions related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 IL4 IL2 IL10
2 MHC class II protein complex binding GO:0023026 9.16 HLA-DRB1 CD4
3 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQB1
4 cytokine activity GO:0005125 8.92 IL4 IL2 IL17A IL10

Sources for Metal Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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