Aliases & Classifications for Metal Allergy

MalaCards integrated aliases for Metal Allergy:

Name: Metal Allergy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060501
UMLS 73 C0577627

Summaries for Metal Allergy

Disease Ontology : 12 A hypersensitivity reaction type I disease triggered by a metal.

MalaCards based summary : Metal Allergy is related to limbic encephalitis with lgi1 antibodies and focal epithelial hyperplasia. An important gene associated with Metal Allergy is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Allograft rejection. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye.

Related Diseases for Metal Allergy

Diseases related to Metal Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
2 focal epithelial hyperplasia 10.2 HLA-DQB1 HLA-DRB1
3 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
4 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
5 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
6 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
7 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
8 autoimmune pancreatitis 10.2 HLA-DQB1 HLA-DRB1
9 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
10 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
11 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
12 whipple disease 10.2 HLA-DQB1 HLA-DRB1
13 acute disseminated encephalomyelitis 10.2 HLA-DQB1 HLA-DRB1
14 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
15 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
16 idiopathic bronchiectasis 10.1 HLA-DQB1 HLA-DRB1
17 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
18 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
19 panuveitis 10.1 HLA-DQB1 HLA-DRB1
20 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
21 severe hemophilia a 10.1 HLA-DQB1 HLA-DRB1
22 ocular cicatricial pemphigoid 10.0 HLA-DQB1 HLA-DRB1
23 dermatitis 10.0
24 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
25 vogt-koyanagi-harada disease 10.0 HLA-DQB1 HLA-DRB1
26 rubella 10.0 HLA-DQB1 HLA-DRB1
27 cerebritis 9.9
28 lichen planus 9.9
29 aneurysm 9.9
30 cerebral aneurysms 9.9
31 graft-versus-host disease 9.9 HLA-DQB1 HLA-DRB1
32 autoimmune hepatitis 9.8 HLA-DQB1 HLA-DRB1
33 pectus excavatum 9.7
34 thrombocytopenia 9.7
35 thrombosis 9.7
36 hypohidrosis 9.7
37 protein s deficiency 9.7
38 contact dermatitis 9.7
39 heparin-induced thrombocytopenia 9.7
40 pustulosis palmaris et plantaris 9.7
41 bone inflammation disease 9.7 HLA-DRB1 TBXAS1
42 bullous pemphigoid 9.7 HLA-DQB1 HLA-DRB1
43 leishmaniasis 9.4 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Metal Allergy:



Diseases related to Metal Allergy

Symptoms & Phenotypes for Metal Allergy

Drugs & Therapeutics for Metal Allergy

Drugs for Metal Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Not Applicable
2 Antibiotics, Antitubercular Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Metal Skin Sensitivity on Restenosis After Stent Implantation Unknown status NCT00226525 Not Applicable
2 Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer Completed NCT00693550
3 Cutaneous and Systemic Reactions to Metal Implants Recruiting NCT02483728 Not Applicable

Search NIH Clinical Center for Metal Allergy

Genetic Tests for Metal Allergy

Anatomical Context for Metal Allergy

MalaCards organs/tissues related to Metal Allergy:

41
Skin, Testes, Eye

Publications for Metal Allergy

Articles related to Metal Allergy:

(show all 33)
# Title Authors Year
1
Metal allergy as a late-onset complication of the Nuss procedure in a pediatric patient. ( 29897675 )
2018
2
Metal Allergy as a Cause of Implant Failure in Shoulder Arthroplasty. ( 28776630 )
2017
3
Selective versus routine patch metal allergy testing to select bar material for the Nuss procedure in 932 patients over 10years. ( 29223667 )
2017
4
Making Sense of Metal Allergy and Hypersensitivity to Metallic Implants in Relation to Hand Surgery. ( 28709788 )
2017
5
Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus. ( 28342246 )
2017
6
Dyshidrotic Eczema and Its Relationship to Metal Allergy. ( 27584966 )
2016
7
Patient-Reported Metal Allergy: A Risk Factor for Poor Outcomes After Total Joint Arthroplasty? ( 26965589 )
2016
8
Influence of Surface Coating on Metal Ion Release: Evaluation in Patients With Metal Allergy. ( 27219723 )
2016
9
Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice. ( 27240418 )
2016
10
Metal allergy to everolimus-eluting cobalt chromium stents confirmed by positive skin testing as a cause of recurrent multivessel in-stent restenosis. ( 26011018 )
2016
11
Metal allergy in eyelid dermatitis and the evaluation of metal contents in eye shadows. ( 27004926 )
2016
12
Diagnosis of metal allergy and management of oral lichenoid reactions. ( 26332591 )
2016
13
Metal allergy after first metatarsophalangeal total joint replacement--Case report. ( 26235863 )
2015
14
Stent thrombosis caused by metal allergy complicated by protein S deficiency and heparin-induced thrombocytopenia: a case report and review of the literature. ( 26207097 )
2015
15
Patch Testing for Metal Allergy With Manufacturer-Supplied Materials Before Nuss Bar Insertion. ( 26551606 )
2015
16
Dermatitis caused by metal allergy after coil embolization for unruptured cerebral aneurysm. ( 26553880 )
2015
17
The association between metal allergy, total knee arthroplasty, and revision: study based on the Danish Knee Arthroplasty Register. ( 25582229 )
2015
18
Prevalence of self-reported metal allergy in patients undergoing primary total knee arthroplasty. ( 24949984 )
2015
19
Dermatitis caused by metal allergy after coil embolization for unruptured cerebral aneurysm. ( 26531730 )
2015
20
High rates of metal allergy amongst Nuss procedure patients dictate broader pre-operative testing. ( 24650476 )
2014
21
Metal release and metal allergy after total hip replacement with resurfacing versus conventional hybrid prosthesis. ( 24930546 )
2014
22
Novel indication for bioabsorbable scaffolds in metal allergy. ( 24333740 )
2014
23
Novel metal allergy patch test using metal nanoballs. ( 25467761 )
2014
24
A prospective study concerning the relationship between metal allergy and post-operative pain following total hip and knee arthroplasty. ( 24910214 )
2014
25
Metal allergy to titanium bars after the Nuss procedure for pectus excavatum. ( 25087797 )
2014
26
Metal allergy screening prior to joint arthroplasty and its influence on implant choice: a delphi consensus study amongst orthopaedic arthroplasty surgeons. ( 24368996 )
2013
27
Close association between metal allergy and nail lichen planus: detection of causative metals in nail lesions. ( 22564023 )
2013
28
Metal allergy and systemic contact dermatitis: an overview. ( 22693488 )
2012
29
Implication of responses to bacterial heat shock proteins, chronic microbial infections, and dental metal allergy in patients with pustulosis palmaris et plantaris. ( 14694830 )
2003
30
High positive frequency of antibodies to metallothionein and heat shock protein 70 in sera of patients with metal allergy. ( 12562388 )
2003
31
Free radicals as potential mediators of metal allergy: effect of ascorbic acid on lymphocyte proliferation and IFN-gamma production in contact allergy to Ni2+ and Co2+. ( 9534884 )
1998
32
[Analysis of a genetic factor of metal allergy--polymorphism of HLA-DR, -DQ gene]. ( 8725357 )
1996
33
Metal allergy in north Norwegian schoolchildren and its relationship with ear piercing and atopy. ( 7867328 )
1994

Variations for Metal Allergy

Expression for Metal Allergy

Search GEO for disease gene expression data for Metal Allergy.

Pathways for Metal Allergy

Pathways related to Metal Allergy according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 CD8A HLA-DQB1 HLA-DRB1
2
Show member pathways
12.28 CD8A HLA-DQB1 HLA-DRB1
3
Show member pathways
11.75 HLA-DQB1 HLA-DRB1
4 11.72 HLA-DQB1 HLA-DRB1
5
Show member pathways
11.55 CD8A HLA-DRB1
6
Show member pathways
11.51 HLA-DQB1 HLA-DRB1
7 11.5 HLA-DQB1 HLA-DRB1
8
Show member pathways
11.49 CD8A HLA-DRB1
9 11.49 CD8A HLA-DQB1 HLA-DRB1
10 11.45 HLA-DQB1 HLA-DRB1
11 11.28 HLA-DQB1 HLA-DRB1
12 11.12 CD8A HLA-DQB1 HLA-DRB1
13 11 HLA-DQB1 HLA-DRB1
14 10.65 CD8A HLA-DQB1 HLA-DRB1

GO Terms for Metal Allergy

Cellular components related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.43 PROK2 TBXAS1
2 trans-Golgi network membrane GO:0032588 9.4 HLA-DQB1 HLA-DRB1
3 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.5 CD8A HLA-DQB1 HLA-DRB1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.43 HLA-DQB1 HLA-DRB1
3 T cell costimulation GO:0031295 9.4 HLA-DQB1 HLA-DRB1
4 interferon-gamma-mediated signaling pathway GO:0060333 9.37 HLA-DQB1 HLA-DRB1
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1
8 antigen processing and presentation GO:0019882 8.8 CD8A HLA-DQB1 HLA-DRB1

Molecular functions related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Metal Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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