MCID: MTL005
MIFTS: 42

Metal Allergy

Categories: Immune diseases, Skin diseases
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Aliases & Classifications for Metal Allergy

MalaCards integrated aliases for Metal Allergy:

Name: Metal Allergy 11 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:0060501
UMLS 71 C0577627

Summaries for Metal Allergy

Disease Ontology: 11 An allergic disease that is triggered by a metal.

MalaCards based summary: Metal Allergy is related to ige responsiveness, atopic and eosinophilic gastritis. An important gene associated with Metal Allergy is HDC (Histidine Decarboxylase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cobalt and Molybdenum have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and t cells, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Metal allergies inflame the skin after it has been in contact with metal. They are a form of allergic... more...

Related Diseases for Metal Allergy

Diseases related to Metal Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 757)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 29.8 IL5 IL4 IL13 IL10
2 eosinophilic gastritis 29.8 IL5 IL13
3 berylliosis 29.8 IL2 CD4
4 eosinophilic gastroenteritis 29.7 IL5 IL4 IL13
5 gingival overgrowth 29.4 TNF IL2 IL10
6 primary cutaneous t-cell non-hodgkin lymphoma 29.4 IL5 IL4 IL2 CD4
7 vasculitis 29.2 TNF IL1B IL17A IL10
8 periapical periodontitis 29.2 TNF IL1B IL17A IL10
9 gastroesophageal reflux 29.1 TNF IL5 IL4 IL1B
10 lichen planus 28.9 TNF IL4 IL2 IL1B IL17A IL10
11 hypereosinophilic syndrome 28.8 IL5 IL4 IL2 IL13 IL10
12 exanthem 28.8 TNF IL4 IL2 IL1B IL17A IL10
13 stomatitis 28.7 TNF IL4 IL2 IL1B IL10 CD4
14 irritable bowel syndrome 28.6 TNF TLR4 IL4 IL1B IL17A IL10
15 gastritis 28.6 TNF TLR4 IL4 IL1B IL17A IL10
16 alopecia 28.6 TNF IL4 IL2 IL1B IL17A FLG
17 periodontitis 28.4 TNF TLR4 IL4 IL2 IL1B IL17A
18 dermatitis 28.4 TNF IL5 IL4 IL2 IL1B IL17A
19 chronic fatigue syndrome 28.3 TNF IL4 IL2 IL1B IL10 CD8A
20 urticaria 28.2 TNF IL5 IL4 IL1B IL17A IL13
21 alopecia areata 28.2 TNF IL4 IL2 IL1B IL17A IL13
22 thrombocytopenia 28.2 TNF TLR4 IL4 IL2 IL1B IL10
23 allergic disease 28.0 TNF IL5 IL4 IL2 IL1B IL17A
24 contact dermatitis 28.0 TNF IL5 IL4 IL2 IL1B IL17A
25 allergic contact dermatitis 27.9 TNF IL5 IL4 IL2 IL1B IL17A
26 ulcerative colitis 27.4 TNF TLR4 IL5 IL4 IL2 IL1B
27 systemic lupus erythematosus 27.2 TNF TLR4 IL5 IL4 IL2 IL1B
28 dermatitis, atopic 27.2 TNF TLR4 IL5 IL4 IL2 IL1B
29 respiratory failure 27.0 TNF TLR4 IL5 IL4 IL2 IL1B
30 skin disease 27.0 TNF TLR4 IL5 IL4 IL2 IL1B
31 periodontitis, aggressive, 1 10.4
32 psoriasis 14, pustular 10.4
33 hilar lung neoplasm 10.3 CD8A CD4
34 oral tuberculosis 10.3 CD8A CD4
35 early yaws 10.3 CD8A CD4
36 ventilation pneumonitis 10.3 CD8A CD4
37 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
38 wissler-fanconi syndrome 10.3 CD8A CD4
39 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
40 encephalitozoonosis 10.3 CD8A CD4
41 cork-handlers' disease 10.3 CD8A CD4
42 follicular mucinosis 10.3 CD8A CD4
43 suppurative lymphadenitis 10.3 CD8A CD4
44 bird fancier's lung 10.3 CD8A CD4
45 parapsoriasis 10.3 CD8A CD4
46 primary syphilis 10.3 CD8A CD4
47 granulomatous angiitis 10.3 CD8A CD4
48 primary cutaneous gamma-delta t-cell lymphoma 10.3 CD8A CD4
49 gastroduodenitis 10.3 CD8A CD4
50 thymic dysplasia 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Metal Allergy:



Diseases related to Metal Allergy

Symptoms & Phenotypes for Metal Allergy

MGI Mouse Phenotypes related to Metal Allergy:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.23 CD4 HDC IL10 IL13 IL17A IL1B
2 growth/size/body region MP:0005378 10.17 CD4 HDC IL10 IL13 IL17A IL1B
3 immune system MP:0005387 10.13 CD4 CD8A HDC IL10 IL13 IL17A
4 no phenotypic analysis MP:0003012 10.1 CD4 HDC IL10 IL13 IL17A IL2
5 liver/biliary system MP:0005370 10.02 IL10 IL17A IL2 IL4 IL5 TLR4
6 digestive/alimentary MP:0005381 10.02 CD4 IL10 IL13 IL17A IL2 IL4
7 endocrine/exocrine gland MP:0005379 10.01 CD4 CD8A IL10 IL13 IL17A IL2
8 neoplasm MP:0002006 9.99 IL10 IL1B IL2 IL5 TLR4 TNF
9 respiratory system MP:0005388 9.86 IL10 IL13 IL17A IL2 IL4 IL5
10 skeleton MP:0005390 9.76 IL10 IL13 IL17A IL1B IL4 SBSN
11 hematopoietic system MP:0005397 9.73 CD4 CD8A HDC IL10 IL13 IL17A
12 integument MP:0010771 9.36 CD4 CD8A HDC IL10 IL13 IL17A

Drugs & Therapeutics for Metal Allergy

Drugs for Metal Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobalt Approved, Experimental, Withdrawn 7440-48-4 104729
2
Molybdenum Approved 7439-98-7 185498
3
Chromium Approved 7440-47-3 27668
4 Kava Approved, Investigational, Nutraceutical 9000-38-8
5
Nickel 7440-02-0 934

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 RESTenosis in Patients With Contact ALLergy to Metals Zabrze Study Unknown status NCT03588962
2 Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder; a RandomizEd Trial. Recruiting NCT04713683

Search NIH Clinical Center for Metal Allergy

Genetic Tests for Metal Allergy

Anatomical Context for Metal Allergy

Organs/tissues related to Metal Allergy:

MalaCards : Skin, Bone Marrow, T Cells, Bone, Eye, Breast

Publications for Metal Allergy

Articles related to Metal Allergy:

(show top 50) (show all 374)
# Title Authors PMID Year
1
Poor Correlation Among Metal Hypersensitivity Testing Modalities and Inferior Patient-Reported Outcomes After Primary and Revision Total Knee Arthroplasties. 62
36345325 2022
2
Metal Allergy in Tracheostomy Tube Placement Resulting in Complete Subglottic Stenosis: A Case Report. 62
34991357 2022
3
Lymphocyte transformation test reveals low prevalence of true metal hypersensitivity among pre-operative total knee arthroplasty patients. 62
35380240 2022
4
[Translated article] Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery. 62
35940560 2022
5
Randomized, placebo-controlled, double-blind clinical trial to evaluate efficacy and safety of topical tranexamic acid in saving blood loss in patients undergoing prosthetic knee surgery. 62
35452861 2022
6
Preoperative Metal Patch Testing and Titanium Bar Use Criteria in Nuss Procedure: A 56-Patients' Cohort Study. 62
35668642 2022
7
Contact allergy to metals in metalworkers: A systematic review and meta-analysis. 62
36208426 2022
8
The effect of Nickel hypersensitivity on the outcome of total knee arthroplasty and the value of skin patch testing: a systematic review. 62
36050799 2022
9
Evaluation of Anterior Lumbar Interbody Fusion Performed Using a Stand-Alone, Integrated Fusion Cage. 62
35940637 2022
10
Surgical technique for Nuss bar exchange due to metal allergy. 62
35973861 2022
11
A comprehensive summary of disease variants implicated in metal allergy. 62
35975293 2022
12
Cervical Implant Allergy With Chronic Neck Pain: A Case Report. 62
36158409 2022
13
The relationship between dental metal allergy, periodontitis, and palmoplantar pustulosis: An observational study. 62
34588402 2022
14
Semaphorin 3A: A potential target for prevention and treatment of nickel allergy. 62
35798870 2022
15
Mixed Metal Allergy Ancillary to Surgical Staples. 62
35983386 2022
16
Oral lichenoid contact lesions related to dental metal allergy may resolve after allergen removal. 62
35784139 2022
17
Application of biomolecules modification strategies on PEEK and its composites for osteogenesis and antibacterial properties. 62
35430485 2022
18
Are there avoidable causes of early revision total knee arthroplasty? 62
35717341 2022
19
Clinical Results of Revision TKA in Patients With Presumed Metal and Cement Allergy. 62
35196568 2022
20
Contact sensitization to iron: A potentially underestimated metal allergen and elicitor of complications in patients with metal implants. 62
35172024 2022
21
Similar clinical and radiographic outcomes after two different hypoallergenic medial unicompartmental knee in patients with metal allergy. 62
35643948 2022
22
Impact of Preoperative Metal Patch Testing on Surgery Using Metal Implants. 62
35330665 2022
23
Metal Hypersensitivity or Missed Periprosthetic Joint Infection? A Critical Review. 62
34978510 2022
24
Similar rates of return to sports and BMI reduction regardless of age, gender and preoperative BMI as seen in matched cohort of hypoallergenic and standard Cobalt Chromium medial unicompartmental knee arthroplasty. 62
33550449 2022
25
Increased inflammatory response is associated with less favorable functional results 5 years after total knee arthroplasty. 62
35147719 2022
26
Aortic valve replacement in a patient with self-reported systemic multiple metal allergy. 62
34562207 2022
27
Subtypes of atopic dermatitis: From phenotype to endotype. 62
34344611 2022
28
Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling. 62
35159975 2022
29
Cutaneous Metal Hypersensitivity Reaction. 62
35496506 2022
30
Evaluation of local tissue peri-implant reaction in total knee arthroplasty failure cases. 62
35521051 2022
31
Patch test-relevant concentrations of metal salts cause localized cytotoxicity, including apoptosis, in skin ex vivo. 62
34268774 2021
32
Methylchloroisothiazolinone and/or Methylisothiazolinone Contact Allergies in Thailand. 62
32209866 2021
33
Case series of metal allergy following Nuss procedure: Not only for stainless steel bars. 62
33487461 2021
34
Metal allergy in primary and revision total knee arthroplasty : a scoping review and evidence-based practical approach. 62
34587776 2021
35
Allergic contact dermatitis to metal allergens in the South of Poland between 2008-2018. 62
34800019 2021
36
Fatigue behaviour of dental crowns made from a novel high-performance polymer PEKK. 62
33506428 2021
37
[Mitral and Aortic Valve Replacement and Tricuspid Valve Repair in a Patient with Metal Allergy]. 62
34334597 2021
38
Memory T helper cells identify patients with nickel, cobalt, and chromium metal allergy. 62
33576045 2021
39
Influence of Psychological Distress in Patients with Hypoallergenic Total Knee Arthroplasty. Treatment Algorithm for Patients with Metal Allergy and Knee Osteoarthritis. 62
34204981 2021
40
Panniculitis as a manifestation of metal-associated autoimmune/inflammatory syndrome induced by adjuvants: a case-based review. 62
34180012 2021
41
Allergy Testing Has No Correlation with Intraoperative Histopathology from Revision Total Knee Arthroplasty for Implant-Related Metal Allergy. 62
33932947 2021
42
The role of metal patch testing in evaluating patients for metallic prosthetic joint failure. 62
33639260 2021
43
Risk factors of ankle osteoarthritis in the treatment of critical bone defects using ilizarov technique. 62
33836698 2021
44
Prevalence, concomitant reactions, and factors associated with fragrance allergy in Thailand. 62
33075139 2021
45
Pulmonary arteriovenous malformation with metal allergy. 62
33692060 2021
46
Suspected Metal Allergy and Femoral Loosening After Total Knee Arthroplasty: A Diagnostic Dilemma. 62
33521207 2021
47
Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity. 62
35003059 2021
48
A Clinical Case Report of a Potential Acute Allergic Reaction with Titanium Dental Implant. 62
33953988 2021
49
The risk factors for occupational contact dermatitis among workers in a medium density fiberboard furniture factory in Eastern Thailand. 62
32924862 2021
50
Metal allergy hypersensitivity after posterior thoracic spinal fusion: A case report and review of the literature. 62
35350829 2021

Variations for Metal Allergy

Expression for Metal Allergy

Search GEO for disease gene expression data for Metal Allergy.

Pathways for Metal Allergy

Pathways related to Metal Allergy according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR4 IL5 IL4 IL2 IL1B
2
Show member pathways
13.81 TNF IL5 IL4 IL2 IL1B IL17A
3
Show member pathways
13.64 CD4 IL10 IL13 IL17A IL1B IL2
4
Show member pathways
13.55 TNF IL5 IL4 IL2 IL1B IL17A
5
Show member pathways
13.4 CD4 IL10 IL13 IL17A IL1B IL2
6
Show member pathways
13.34 TNF IL5 IL4 IL2 IL1B IL17A
7
Show member pathways
13.32 TNF IL5 IL4 IL2 IL1B IL17A
8
Show member pathways
12.68 IL10 IL13 IL17A IL1B IL2 IL4
9
Show member pathways
12.66 CD4 IL10 IL17A IL1B IL2 TNF
10
Show member pathways
12.65 TNF TLR4 IL2 IL1B
11 12.63 TNF IL4 IL2 IL1B IL17A IL10
12
Show member pathways
12.44 IL5 IL2 IL1B IL13
13
Show member pathways
12.42 TNF TLR4 IL4 IL1B
14 12.21 IL10 IL13 IL1B TNF
15 12.19 TNF IL4 IL1B IL13 IL10
16
Show member pathways
12.15 CD4 CD8A IL10 IL17A IL2 IL4
17
Show member pathways
12.12 TLR4 IL5 IL2 IL1B IL13
18 12.09 TNF TLR4 IL4 IL2 IL1B
19 12.09 TNF IL5 IL4 IL2 IL10 CD8A
20
Show member pathways
12.07 IL4 IL2 IL1B CD8A CD4
21 12.03 TNF IL4 IL1B IL17A IL13 IL10
22
Show member pathways
11.98 TNF TLR4 IL2 IL1B IL17A IL10
23
Show member pathways
11.97 CD4 IL17A IL1B IL4 TLR4
24 11.87 IL5 IL4 IL2 IL13
25 11.86 CD4 CD8A IL10 IL13 IL17A IL1B
26 11.85 CD4 IL10 IL2 TLR4
27 11.85 FLG IL1B TLR4 TNF
28 11.85 TNF TLR4 IL4 IL2 IL10
29 11.84 TNF IL2 IL1B IL10 CD8A CD4
30 11.83 IL4 IL2 IL1B IL17A CD4
31 11.81 IL5 IL4 IL2 IL10
32
Show member pathways
11.8 TNF IL5 IL4 IL2
33 11.78 TNF IL5 IL4 IL1B IL13
34 11.76 TNF TLR4 IL1B IL10
35 11.73 IL10 IL13 IL17A IL1B IL2 IL4
36
Show member pathways
11.69 TNF IL2 IL1B
37 11.68 TNF TLR4 IL10
38 11.67 IL5 IL4 IL10
39 11.65 TNF IL4 IL2 IL10 CD4
40
Show member pathways
11.64 TNF TLR4 IL5 IL4 IL2 IL13
41 11.63 TNF TLR4 CD4
42 11.6 IL5 IL4 IL2 IL13 IL10 CD4
43 11.56 TNF TLR4 IL1B
44 11.55 TNF IL1B IL10
45 11.48 TNF TLR4 IL1B IL10
46
Show member pathways
11.43 TNF IL2 IL10
47 11.39 IL5 IL4 IL2
48 11.39 TNF IL5 IL4 IL1B IL17A IL13
49 11.32 TNF IL1B IL17A
50 11.32 IL10 IL13 IL2 IL4 IL5

GO Terms for Metal Allergy

Cellular components related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TNF SBSN IL5 IL4 IL2 IL1B
2 external side of plasma membrane GO:0009897 9.4 TNF TLR4 IL17A IL13 CD8A CD4

Biological processes related to Metal Allergy according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.29 CD4 IL1B TLR4 TNF
2 inflammatory response GO:0006954 10.27 TNF TLR4 IL5 IL1B IL17A IL13
3 cellular response to lipopolysaccharide GO:0071222 10.22 IL10 IL1B TLR4 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.2 TNF IL5 IL1B IL10
5 negative regulation of tumor necrosis factor production GO:0032720 10.19 TLR4 IL4 IL10
6 negative regulation of inflammatory response GO:0050728 10.19 IL4 IL2 IL13 IL10
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.18 TNF TLR4 IL1B
8 positive regulation of interleukin-8 production GO:0032757 10.18 IL1B TLR4 TNF
9 positive regulation of interleukin-1 beta production GO:0032731 10.18 TNF TLR4 IL17A
10 negative regulation of interleukin-6 production GO:0032715 10.17 TNF TLR4 IL10
11 JNK cascade GO:0007254 10.16 TNF TLR4 IL1B
12 positive regulation of inflammatory response GO:0050729 10.16 TNF TLR4 IL2 IL1B
13 T cell activation GO:0042110 10.15 IL4 CD8A CD4
14 positive regulation of smooth muscle cell proliferation GO:0048661 10.15 TNF TLR4 IL13
15 positive regulation of interleukin-6 production GO:0032755 10.13 TNF TLR4 IL1B IL17A
16 positive regulation of nitric oxide biosynthetic process GO:0045429 10.12 IL1B TLR4 TNF
17 positive regulation of interleukin-10 production GO:0032733 10.11 TLR4 IL4 IL13
18 lipopolysaccharide-mediated signaling pathway GO:0031663 10.1 TNF TLR4 IL1B
19 positive regulation of T cell proliferation GO:0042102 10.09 IL4 IL2 IL1B
20 I-kappaB kinase/NF-kappaB signaling GO:0007249 10.09 TNF TLR4 IL1B
21 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.09 TNF IL5 IL10
22 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 10.09 IL4 IL2 IL1B
23 negative regulation of endothelial cell apoptotic process GO:2000352 10.08 IL10 IL13 IL4
24 positive regulation of chemokine production GO:0032722 10.04 TNF TLR4 IL1B
25 positive regulation of type II interferon production GO:0032729 10.03 TNF TLR4 IL2 IL1B
26 microglial cell activation GO:0001774 10.02 IL13 IL4 TNF
27 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 10.01 TNF TLR4
28 negative regulation of T-helper 17 cell differentiation GO:2000320 10.01 IL4 IL2
29 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.01 IL17A TLR4 TNF
30 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.01 TNF IL4 IL2 IL13
31 type 2 immune response GO:0042092 9.99 IL4 IL10
32 vascular endothelial growth factor production GO:0010573 9.98 TNF IL1B
33 positive regulation of oxidative stress-induced neuron death GO:1903223 9.97 TNF TLR4
34 positive regulation of mononuclear cell migration GO:0071677 9.96 TNF IL4
35 negative regulation of cytokine production involved in immune response GO:0002719 9.96 TNF IL10
36 intestinal epithelial structure maintenance GO:0060729 9.96 TLR4 IL17A
37 positive regulation of fever generation GO:0031622 9.95 TNF IL1B
38 macrophage activation GO:0042116 9.95 IL13 IL4 TLR4
39 regulation of isotype switching GO:0045191 9.93 IL4 IL10
40 sequestering of triglyceride GO:0030730 9.93 TNF IL1B
41 positive regulation of macrophage activation GO:0043032 9.93 IL10 IL13 TLR4
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.88 IL1B TNF
43 positive regulation of plasma cell differentiation GO:1900100 9.88 IL10 IL2
44 negative regulation of complement-dependent cytotoxicity GO:1903660 9.87 IL13 IL4
45 response to lipopolysaccharide GO:0032496 9.86 IL10 IL13 IL1B TLR4 TNF
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.85 TNF IL1B IL10
47 chronic inflammatory response to antigenic stimulus GO:0002439 9.81 TNF IL10
48 positive regulation of MHC class II biosynthetic process GO:0045348 9.8 TLR4 IL4 IL10
49 positive regulation of immunoglobulin production GO:0002639 9.76 IL5 IL2 IL13 IL10
50 lymphocyte proliferation GO:0046651 9.7 TLR4 IL2

Molecular functions related to Metal Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL5 IL4 IL2 IL10
2 cytokine activity GO:0005125 9.53 TNF IL5 IL4 IL2 IL1B IL17A

Sources for Metal Allergy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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