MCID: MTN001
MIFTS: 39

Metanephric Adenoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Metanephric Adenoma

MalaCards integrated aliases for Metanephric Adenoma:

Name: Metanephric Adenoma 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:6404
NCIt 50 C27253
SNOMED-CT 67 128670007
UMLS 70 C1266045

Summaries for Metanephric Adenoma

MalaCards based summary : Metanephric Adenoma is related to papillary carcinoma and renal cell carcinoma, papillary, 1, and has symptoms including abdominal pain and flank pain. An important gene associated with Metanephric Adenoma is KRT7 (Keratin 7), and among its related pathways/superpathways are ERK Signaling and Cytoskeletal Signaling. Affiliated tissues include kidney, thyroid and ovary, and related phenotype is Reduced mammosphere formation.

Wikipedia : 73 Metanephric adenoma (MA)is a rare, benign tumour of the kidney, that can have a microscopic appearance... more...

Related Diseases for Metanephric Adenoma

Diseases related to Metanephric Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 papillary carcinoma 30.8 MUC1 KRT7 BRAF
2 renal cell carcinoma, papillary, 1 30.6 WT1 KRT7 BRAF B3GAT1 AMACR
3 papillary adenoma 30.6 VIM KRT7 AMACR
4 wilms tumor 1 30.3 WT1 VIM MUC1 KRT7 BRAF AMACR
5 nephrogenic adenofibroma 30.3 WT1 KRT7 B3GAT1
6 adenofibroma 30.2 VIM MUC1 KRT7 BRAF
7 spindle cell sarcoma 30.2 VIM MUC1 KRT7
8 renal adenoma 30.2 WT1 KRT7 KANK1 B3GAT1 AMACR
9 renal cell carcinoma, nonpapillary 30.2 WT1 VIM MUC1 KRT7 KRT18 BRAF
10 nephroma 30.2 WT1 VIM MUC1
11 rhabdoid cancer 30.1 WT1 VIM MUC1
12 epithelial predominant wilms' tumor 30.1 WT1 KRT7 B3GAT1 AMACR
13 oncocytoma 30.0 VIM MUC1 KRT7 KRT18 AMACR
14 transitional cell carcinoma 29.9 KRT7 KRT18 BRAF
15 gastrointestinal stromal tumor 29.7 WT1 VIM BRAF B3GAT1
16 sarcoma 29.3 WT1 VIM MUC1 CXCL8 BRAF
17 adenoma 10.9
18 chromophil renal cell carcinoma 10.7
19 polycythemia 10.5
20 rare tumor 10.4
21 bladder benign neoplasm 10.4 KRT7 AMACR
22 nephrogenic adenoma of urinary bladder 10.4 KRT7 AMACR
23 wolffian duct adenoma 10.4 KRT7 AMACR
24 scrotum paget's disease 10.4 MUC1 KRT7
25 female urethral cancer 10.4 KRT7 AMACR
26 gallbladder signet ring cell adenocarcinoma 10.4 MUC1 KRT7
27 pancreatic foamy gland adenocarcinoma 10.4 MUC1 KRT7
28 urinary bladder villous adenoma 10.4 MUC1 KRT7
29 clear cell papillary renal cell carcinoma 10.4 KRT7 AMACR
30 urethral diverticulum 10.4 KRT7 AMACR
31 chromophil adenoma of the kidney 10.4 KRT7 AMACR
32 mucinous intrahepatic cholangiocarcinoma 10.4 MUC1 KRT7
33 middle ear adenoma 10.4 MUC1 KRT7
34 bile duct cystadenocarcinoma 10.4 MUC1 KRT7
35 colonic lymphangioma 10.4 MUC1 KRT7
36 biliary papillomatosis 10.4 MUC1 KRT7
37 bile duct mucoepidermoid carcinoma 10.4 MUC1 KRT7
38 nephrogenic adenoma of the urethra 10.4 KRT7 AMACR
39 lipoadenoma 10.4 MUC1 KRT7
40 pancreatic mucinous cystadenoma 10.3 MUC1 KRT7
41 biliary tract benign neoplasm 10.3 MUC1 KRT7
42 bladder lateral wall cancer 10.3 KRT7 AMACR
43 solid adenocarcinoma with mucin production 10.3 MUC1 KRT7
44 benign metastasizing leiomyoma 10.3 VIM KRT7
45 urethral benign neoplasm 10.3 KRT7 AMACR
46 ovarian serous cystadenofibroma 10.3 MUC1 KRT7
47 microinvasive cervical squamous cell carcinoma 10.3 WT1 KRT7
48 mixed fibrolamellar hepatocellular carcinoma 10.3 MUC1 KRT7
49 nodular hidradenoma 10.3 VIM MUC1
50 ovarian seromucinous carcinoma 10.3 WT1 KRT7

Graphical network of the top 20 diseases related to Metanephric Adenoma:



Diseases related to Metanephric Adenoma

Symptoms & Phenotypes for Metanephric Adenoma

UMLS symptoms related to Metanephric Adenoma:


abdominal pain; flank pain

GenomeRNAi Phenotypes related to Metanephric Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 BRAF CSF3 CXCL8 KRT18 KRT7 VIM

Drugs & Therapeutics for Metanephric Adenoma

Search Clinical Trials , NIH Clinical Center for Metanephric Adenoma

Genetic Tests for Metanephric Adenoma

Anatomical Context for Metanephric Adenoma

MalaCards organs/tissues related to Metanephric Adenoma:

40
Kidney, Thyroid, Ovary

Publications for Metanephric Adenoma

Articles related to Metanephric Adenoma:

(show top 50) (show all 225)
# Title Authors PMID Year
1
ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217. 61
32467651 2020
2
ALK-rearranged renal cell carcinoma-different morphological faces of a rare tumor : Editorial to Hang et al.: ALK-rearranged renal cell carcinoma with a novel PLEKHA7-ALK translocation and metanephric adenoma-like morphology. 61
32072245 2020
3
Metanephric adenoma with BRAF V600K mutation and a doubtful radiological imaging: pitfalls in the diagnostic process. 61
33175195 2020
4
KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas. 61
33046021 2020
5
Secondary renal neoplasia following chemotherapy or radiation in pediatric patients. 61
32681944 2020
6
Experience of diagnosis and management of metanephric adenoma: retrospectively analysis of 10 cases and a literature review. 61
32944527 2020
7
Metanephric Adenoma with cystic changes- An uncommon presentation of a rare tumor in a young adult. 61
33344292 2020
8
ALK-rearranged renal cell carcinoma with a novel PLEKHA7-ALK translocation and metanephric adenoma-like morphology. 61
31993771 2020
9
Advanced Molecular Imaging in Histologically Verified Metanephric Adenoma. 61
32171695 2020
10
Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey 61
31655501 2020
11
Biphasic squamoid alveolar renal carcinoma with positive CD57 expression: A clinicopathologic study of three cases. 61
31369187 2019
12
Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status. 61
31192863 2019
13
Imaging features of metanephric adenoma and their pathological correlation. 61
30803811 2019
14
Pediatric Renal Neoplasms:: MR Imaging-Based Practical Diagnostic Approach. 61
30910098 2019
15
The history of urologic pathology: an overview. 61
30565309 2019
16
Metanephric adenoma. A case report and literature review. 61
31726842 2019
17
Metanephric adenoma with low apparent diffusion coefficient value mimicking renal cell carcinoma: A case report. 61
30544462 2018
18
Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis. 61
30504374 2018
19
Metanephric Adenoma in the Pediatric Population: Diagnostic Challenges and Follow-up. 61
30006267 2018
20
Robotic-assisted laparoscopic surgery for pediatric tumors: a bicenter experience. 61
29288372 2018
21
[Metanephric Adenoma : A Report of Two Cases]. 61
30369221 2018
22
Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases. 61
30111351 2018
23
[Clinicopathologic features of myxoid adrenocortical adenomas]. 61
29996318 2018
24
Characterization of Small Renal Tumors With Magnetic Resonance Elastography: A Feasibility Study. 61
29462024 2018
25
[Clinical features analysis of metanephric adenoma: a series of 16 cases]. 61
29534419 2018
26
[All large necrotic and hemorrhagic kidney tumors in children are not necessarily malignant: A case of a 7-month-old child]. 61
29169835 2017
27
[Adenoma metanephric: Report of 2 cases and bibliographic review.] 61
29099381 2017
28
Metanephric adenoma treated with laparoscopic nephrectomy: A case report. 61
28894579 2017
29
Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation. 61
28903326 2017
30
A novel cytogenetic and molecular characterization of renal metanephric adenoma: Identification of partner genes involved in translocation t(9;15)(p24;q24). 61
28595733 2017
31
Large Cystic Metanephric Adenoma in a 15-Year-Old Girl. 61
28011277 2017
32
BRAF exon 15 mutations in pediatric renal stromal tumors: prevalence in metanephric stromal tumors. 61
27769870 2017
33
[Molecular features of metanephric adenoma and their values in differential diagnosis]. 61
28072975 2017
34
The findings of CT and MRI in patients with metanephric adenoma. 61
27784295 2016
35
[Clinicopathological features and differential diagnosis of metanephric adenoma: a report of sixteen cases]. 61
29263496 2016
36
A Case of Metanephric Adenoma and Acute Myocardial Infarction. 61
27471365 2016
37
[Expression of cadherin17 in metanephric adenoma and its value in differential diagnosis]. 61
27430690 2016
38
The Clinical Characteristics of Metanephric Adenoma: A Case Report and Literature Review. 61
27227914 2016
39
Absence of Canonical WNT Signaling in Adult Renal Cell Tumors of Embryonal Origin. 61
27127119 2016
40
Prominent apical cytoplasmic bleb formation in metanephric adenoma: report of a case. 61
26508100 2016
41
Metanephric adenoma: Cytological, histological, and molecular diagnosis of a case. 61
26800350 2016
42
[Clinicopathological features and differential diagnosis of metanephric adenoma: a report of sixteen cases]. 61
27538135 2016
43
Retroperitoneal laparoscopic partial nephrectomy for treatment of metanephric adenoma (Report of 6 cases). 61
27398273 2016
44
A metanephric adenoma of the kidney associated with polycythemia: A case report. 61
26870216 2016
45
METANEPHRIC ADENOMA DIAGNOSED PREOPERATIVELY AS RENAL CELL CARCINOMA: A REPORT OF TWO CASES. 61
29070739 2016
46
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature. 61
26486745 2015
47
Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. 61
26248896 2015
48
Unusual benign solid neoplasms of the kidney: cross-sectional imaging findings. 61
26200482 2015
49
Metanephric adenoma with diffuse calcifications: A case report. 61
26622757 2015
50
BRAF mutations in pediatric metanephric tumors. 61
26014474 2015

Variations for Metanephric Adenoma

Cosmic variations for Metanephric Adenoma:

9 (show top 50) (show all 1659)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87583829 ZNF462 kidney,NS,carcinoma,papillary renal cell carcinoma c.7085G>A p.R2362Q 9:107003322-107003322 3
2 COSM109100722 ZNF462 kidney,NS,carcinoma,papillary renal cell carcinoma c.3803G>A p.R1268Q 9:107003322-107003322 3
3 COSM151995781 ZNF281 kidney,NS,carcinoma,papillary renal cell carcinoma c.2093C>T p.P698L 1:200407613-200407613 3
4 COSM93625940 ZNF281 kidney,NS,carcinoma,papillary renal cell carcinoma c.2093C>T p.P698L 1:200407613-200407613 3
5 COSM93623781 ZNF281 kidney,NS,carcinoma,papillary renal cell carcinoma c.1985C>T p.P662L 1:200407613-200407613 3
6 COSM140954956 ZNF225 kidney,NS,carcinoma,papillary renal cell carcinoma c.1187G>T p.G396V 19:44131801-44131801 3
7 COSM140688909 ZNF225 kidney,NS,carcinoma,papillary renal cell carcinoma c.*968G>T p.? 19:44131801-44131801 3
8 COSM85326448 ZNF225 kidney,NS,carcinoma,papillary renal cell carcinoma c.1187G>T p.G396V 19:44131801-44131801 3
9 COSM112895347 ZNF142 kidney,NS,carcinoma,papillary renal cell carcinoma c.3811G>T p.D1271Y 2:218642705-218642705 3
10 COSM105902090 ZNF142 kidney,NS,carcinoma,papillary renal cell carcinoma c.3811G>T p.D1271Y 2:218642705-218642705 3
11 COSM102023492 ZFHX3 kidney,NS,carcinoma,papillary renal cell carcinoma c.-23-6591T>C p.? 16:72957556-72957556 3
12 COSM87274574 ZFHX3 kidney,NS,carcinoma,papillary renal cell carcinoma c.2590T>C p.Y864H 16:72957556-72957556 3
13 COSM149269629 ZFHX3 kidney,NS,carcinoma,papillary renal cell carcinoma c.2590T>C p.Y864H 16:72957556-72957556 3
14 COSM89411866 ZBTB2 kidney,NS,carcinoma,papillary renal cell carcinoma c.931G>A p.E311K 6:151366135-151366135 3
15 COSM87436198 XPO4 kidney,NS,carcinoma,papillary renal cell carcinoma c.1299C>A p.F433L 13:20809842-20809842 3
16 COSM105761507 XPO4 kidney,NS,carcinoma,papillary renal cell carcinoma c.1299C>A p.F433L 13:20809842-20809842 3
17 COSM104888966 XPO1 kidney,NS,carcinoma,papillary renal cell carcinoma c.259A>G p.I87V 2:61522653-61522653 3
18 COSM104241577 XPO1 kidney,NS,carcinoma,papillary renal cell carcinoma c.259A>G p.I87V 2:61522653-61522653 3
19 COSM101982001 XPO1 kidney,NS,carcinoma,papillary renal cell carcinoma c.259A>G p.I87V 2:61522653-61522653 3
20 COSM136040220 XKR7 kidney,NS,carcinoma,papillary renal cell carcinoma c.1409C>T p.T470M 20:31997126-31997126 3
21 COSM108082894 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 3
22 COSM92179769 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 3
23 COSM94289415 XIAP kidney,NS,carcinoma,renal cell carcinoma unclassified c.563G>C p.G188A 23:123886225-123886225 3
24 COSM101580971 WDR89 kidney,NS,carcinoma,papillary renal cell carcinoma c.260C>A p.S87* 14:63599683-63599683 3
25 COSM145076301 WDR89 kidney,NS,carcinoma,papillary renal cell carcinoma c.260C>A p.S87* 14:63599683-63599683 3
26 COSM86850934 WDR89 kidney,NS,carcinoma,papillary renal cell carcinoma c.260C>A p.S87* 14:63599683-63599683 3
27 COSM90652475 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.245G>C p.R82P 3:10142092-10142092 3
28 COSM90649111 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-3275A>T p.? 3:10146512-10146512 3
29 COSM88295075 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.556G>T p.E186* 3:10149879-10149879 3
30 COSM88289113 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-2A>T p.? 3:10146512-10146512 3
31 COSM90649287 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.217C>T p.Q73* 3:10142064-10142064 3
32 COSM90655230 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.264G>C p.W88C 3:10142111-10142111 3
33 COSM88304452 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.443T>C p.F148S 3:10146616-10146616 3
34 COSM88294223 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.499C>T p.R167W 3:10149822-10149822 3
35 COSM88297043 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 3:10149808-10149808 3
36 COSM90650671 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.341-3261T>C p.? 3:10146526-10146526 3
37 COSM90671077 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.400T>G p.Y134D 3:10149846-10149846 3
38 COSM88292918 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.500G>A p.R167Q 3:10149823-10149823 3
39 COSM88288959 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.482G>A p.R161Q 3:10149805-10149805 3
40 COSM88292107 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.256C>T p.P86S 3:10142103-10142103 3
41 COSM90652409 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.234T>G p.N78K 3:10142081-10142081 3
42 COSM88293667 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.548C>A p.S183* 3:10149871-10149871 3
43 COSM90657935 VHL kidney,NS,carcinoma,renal cell c.362G>T p.C121F 3:10149808-10149808 3
44 COSM90649307 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.266T>A p.L89H 3:10142113-10142113 3
45 COSM88290223 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.341G>C p.G114A 3:10146514-10146514 3
46 COSM90655004 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.376C>T p.R126W 3:10149822-10149822 3
47 COSM88289297 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.266T>A p.L89H 3:10142113-10142113 3
48 COSM88290436 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.353T>C p.L118P 3:10146526-10146526 3
49 COSM88292022 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.245G>C p.R82P 3:10142092-10142092 3
50 COSM90653546 VHL kidney,NS,carcinoma,renal cell carcinoma unclassified c.377G>A p.R126Q 3:10149823-10149823 3

Copy number variations for Metanephric Adenoma from CNVD:

7 (show all 34)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 13793 1 1 51300000 Gain Metanephric adenoma
2 24331 1 178600000 205300000 Loss Metanephric adenoma
3 43851 10 50100000 71300000 Loss Metanephric adenoma
4 56500 11 59700000 70700000 Gain Metanephric adenoma
5 56501 11 59700000 74900000 Gain Metanephric adenoma
6 67783 12 44600000 61400000 Gain Metanephric adenoma
7 69822 12 56300000 94800000 Loss Metanephric adenoma
8 70920 12 66000000 91200000 Loss Metanephric adenoma
9 78014 13 48900000 97000000 Loss Metanephric adenoma
10 84882 14 35600000 52300000 Loss Metanephric adenoma
11 97247 16 1 34400000 Gain Metanephric adenoma
12 106743 17 1 11200000 Gain Metanephric adenoma
13 109764 17 28800000 47600000 Gain Metanephric adenoma
14 109766 17 28800000 78774742 Gain Metanephric adenoma
15 119821 18 17300000 76117153 Loss Metanephric adenoma
16 124073 19 1 19800000 Gain Metanephric adenoma
17 124091 19 1 26700000 Gain Metanephric adenoma
18 127805 19 37100000 57600000 Gain Metanephric adenoma
19 127807 19 37100000 63811651 Gain Metanephric adenoma
20 157127 21 13200000 34700000 Loss Metanephric adenoma
21 160311 22 11800000 49691432 Gain Metanephric adenoma
22 160871 22 16300000 47000000 Gain Metanephric adenoma
23 178372 3 71800000 91700000 Loss Metanephric adenoma
24 187565 4 52400000 187300000 Loss Metanephric adenoma
25 191443 5 1 135400000 Loss Metanephric adenoma
26 209384 6 26100000 45200000 Gain Metanephric adenoma
27 218055 7 107200000 126900000 Loss Metanephric adenoma
28 227757 7 71800000 97900000 Loss Metanephric adenoma
29 228540 7 77400000 126900000 Loss Metanephric adenoma
30 240253 8 48100000 146274826 Loss Metanephric adenoma
31 246807 9 125800000 140273252 Gain Metanephric adenoma
32 253828 9 4600000 36300000 Loss Metanephric adenoma
33 257105 X 1 154913754 Loss Metanephric adenoma
34 264059 X 59500000 154913754 Loss Metanephric adenoma

Expression for Metanephric Adenoma

Search GEO for disease gene expression data for Metanephric Adenoma.

Pathways for Metanephric Adenoma

Pathways related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 VIM MUC1 KRT18 CXCL8 CSF3 CDH17
2 11.41 VIM MUC1 KRT7 KRT18
3 11.39 VIM MUC1 CXCL8
4
Show member pathways
11.17 VIM KRT7 KRT18

GO Terms for Metanephric Adenoma

Biological processes related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.46 WT1 VIM CXCL8 BRAF
2 cellular response to lipopolysaccharide GO:0071222 9.13 VIM CXCL8 CSF3
3 cytokine-mediated signaling pathway GO:0019221 8.92 VIM MUC1 CXCL8 CSF3

Molecular functions related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.8 VIM KRT18 BRAF

Sources for Metanephric Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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