Aliases & Classifications for Metanephric Adenoma

MalaCards integrated aliases for Metanephric Adenoma:

Name: Metanephric Adenoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6404
NCIt 50 C27253
SNOMED-CT 68 128670007
UMLS 73 C1266045

Summaries for Metanephric Adenoma

MalaCards based summary : Metanephric Adenoma is related to papillary adenoma and rhabdoid cancer, and has symptoms including abdominal pain and flank pain. An important gene associated with Metanephric Adenoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Cytoskeletal Signaling and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include kidney and lymph node, and related phenotypes are Reduced mammosphere formation and liver/biliary system

Wikipedia : 76 Metanephric adenoma (MA)is a rare, benign tumour of the kidney, that can have a microscopic appearance... more...

Related Diseases for Metanephric Adenoma

Diseases related to Metanephric Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 papillary adenoma 30.7 KRT7 VIM
2 rhabdoid cancer 29.9 VIM WT1
3 papillary carcinoma 29.6 BRAF KRT7
4 renal cell carcinoma, papillary, 1 29.4 AMACR BRAF KRT7 WT1
5 renal cell carcinoma, nonpapillary 29.3 AMACR KRT7 VIM WT1
6 adenoma 10.9
7 clear cell papillary renal cell carcinoma 10.6 AMACR KRT7
8 ovarian mucinous adenocarcinoma 10.6 AMACR KRT7
9 nephrogenic adenoma 10.5 AMACR KRT7
10 kidney benign neoplasm 10.5 AMACR KRT7
11 papillary craniopharyngioma 10.5 BRAF KRT7
12 collecting duct carcinoma 10.5 AMACR KRT7
13 proliferating trichilemmal cyst 10.5 KRT18 KRT7
14 parachordoma 10.4 KRT7 VIM
15 adenoid squamous cell carcinoma 10.4 KRT7 VIM
16 epithelioid trophoblastic tumor 10.4 KRT18 KRT7
17 cutaneous adenocystic carcinoma 10.4 KRT18 KRT7
18 malignant mixed mullerian tumor 10.4 KRT7 VIM
19 nodular hidradenoma 10.4 KRT7 VIM
20 benign metastasizing leiomyoma 10.4 KRT7 VIM
21 monophasic synovial sarcoma 10.4 KRT7 VIM
22 spiradenoma 10.4 KRT7 VIM
23 medulloepithelioma 10.4 KRT7 VIM
24 seminal vesicle tumor 10.4 KRT18 KRT7
25 hidradenoma 10.4 KRT7 VIM
26 clear cell adenocarcinoma 10.4 AMACR KRT7
27 pleomorphic carcinoma 10.4 KRT18 KRT7
28 mucinous cystadenocarcinoma 10.4 KRT7 VIM
29 lymphoepithelioma-like carcinoma 10.4 KRT18 KRT7
30 endocervical adenocarcinoma 10.4 KRT7 VIM
31 dermoid cyst 10.4 KRT7 VIM
32 spindle cell sarcoma 10.4 KRT7 VIM
33 papillary tumor of the pineal region 10.4 BRAF VIM
34 rhabdoid meningioma 10.3 BRAF VIM
35 endodermal sinus tumor 10.3 KRT7 VIM
36 endosalpingiosis 10.3 KRT7 WT1
37 granulosa cell tumor of the ovary 10.3 KRT7 VIM
38 syringocystadenoma papilliferum 10.3 BRAF VIM
39 female reproductive endometrioid cancer 10.3 KRT7 WT1
40 hidradenocarcinoma 10.3 KRT7 VIM
41 adenofibroma 10.3 BRAF VIM
42 mammary paget's disease 10.3 KRT18 KRT7
43 intraneural perineurioma 10.3 KRT18 KRT7
44 juvenile xanthogranuloma 10.3 BRAF VIM
45 papillary adenocarcinoma 10.3 KRT7 VIM
46 secretory meningioma 10.3 KRT7 VIM
47 pericardial mesothelioma 10.3 KRT7 VIM
48 epithelioid sarcoma 10.3 KRT7 VIM
49 sertoli-leydig cell tumor 10.3 KRT7 WT1
50 malignant biphasic mesothelioma 10.3 KRT7 WT1

Graphical network of the top 20 diseases related to Metanephric Adenoma:



Diseases related to Metanephric Adenoma

Symptoms & Phenotypes for Metanephric Adenoma

UMLS symptoms related to Metanephric Adenoma:


abdominal pain, flank pain

GenomeRNAi Phenotypes related to Metanephric Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 BRAF KRT18 KRT7 VIM

MGI Mouse Phenotypes related to Metanephric Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 AMACR BRAF KRT18 WT1

Drugs & Therapeutics for Metanephric Adenoma

Search Clinical Trials , NIH Clinical Center for Metanephric Adenoma

Genetic Tests for Metanephric Adenoma

Anatomical Context for Metanephric Adenoma

MalaCards organs/tissues related to Metanephric Adenoma:

41
Kidney, Lymph Node

Publications for Metanephric Adenoma

Articles related to Metanephric Adenoma:

(show top 50) (show all 122)
# Title Authors Year
1
A novel cytogenetic and molecular characterization of renal metanephric adenoma: Identification of partner genes involved in translocation t(9;15)(p24;q24). ( 28595733 )
2017
2
Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation. ( 28903326 )
2017
3
Metanephric adenoma treated with laparoscopic nephrectomy: A case report. ( 28894579 )
2017
4
Large Cystic Metanephric Adenoma in a 15-Year-Old Girl. ( 28011277 )
2016
5
A Case of Metanephric Adenoma and Acute Myocardial Infarction. ( 27471365 )
2016
6
The Clinical Characteristics of Metanephric Adenoma: A Case Report and Literature Review. ( 27227914 )
2016
7
The findings of CT and MRI in patients with metanephric adenoma. ( 27784295 )
2016
8
Retroperitoneal laparoscopic partial nephrectomy for treatment of metanephric adenoma (Report of 6 cases). ( 27398273 )
2016
9
Metanephric adenoma: Cytological, histological, and molecular diagnosis of a case. ( 26800350 )
2016
10
Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation. ( 27517493 )
2016
11
A metanephric adenoma of the kidney associated with polycythemia: A case report. ( 26870216 )
2016
12
Cytologic features of metanephric adenoma of the kidney: case report and review of the literature. ( 25918196 )
2015
13
Cadherin 17 is a sensitive and specific marker for metanephric adenoma. ( 25768256 )
2015
14
Laparoscopic Nephron-sparing Surgery for Metanephric Adenoma in Children: A Report of 2 Cases. ( 26142601 )
2015
15
CT imaging spectrum and the histopathological features of adult metanephric adenoma. ( 25966289 )
2015
16
Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. ( 26248896 )
2015
17
Prominent apical cytoplasmic bleb formation in metanephric adenoma: report of a case. ( 26508100 )
2015
18
Molecular and Immunohistochemical Characterization Reveals Novel BRAF Mutations in Metanephric Adenoma. ( 25602792 )
2015
19
Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma. ( 26261480 )
2015
20
Metanephric adenoma: MR imaging features with histopathological correlation. ( 25487835 )
2015
21
The imaging features of metanephric adenoma: a case report and review of literature. ( 25709478 )
2015
22
Adult metanephric adenoma presumed to be all benign? A clinical perspective. ( 25907695 )
2015
23
Congenital Renal Tumour: Metanephric Adenoma or Malignancy? ( 25734608 )
2015
24
Metanephric adenoma with diffuse calcifications: A case report. ( 26622757 )
2015
25
Pediatric and Perinatal Pathology: SY21-5 CONGENITAL RENAL TUMOUR: METANEPHRIC ADENOMA OR MALIGNANCY? ( 25188148 )
2014
26
CT features of metanephric adenoma: a case report and review of the literature. ( 25525587 )
2014
27
Immunohistochemical staining for braf v600e supports the diagnosis of metanephric adenoma. ( 25130952 )
2014
28
Clinicopathological study and diagnosis of rhabdoid tumor of kidney combined with metanephric adenoma. ( 25533836 )
2014
29
Renal metanephric adenoma mimicking papillary renal cell carcinoma on computed tomography: a case report. ( 23076029 )
2013
30
Pediatric metanephric adenoma: case report and review of the literature. ( 24097278 )
2013
31
The clinical and CT imaging features of metanephric adenoma. ( 23884840 )
2013
32
A renal metanephric adenoma showing both a 2p16e24 deletion and BRAF V600E mutation: a synergistic role for a tumor suppressor gene on chromosome 2p and BRAF activation? ( 24432405 )
2013
33
Radiofrequency-assisted partial nephrectomy for metanephric adenoma: a case report and literature review. ( 22474015 )
2013
34
Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features. ( 23551615 )
2013
35
Fine-needle aspiration of metanephric adenoma of the kidney with clinical, radiographic and histopathologic correlation: a review. ( 23447142 )
2013
36
Composite tumor of metanephric adenoma and Wilms' tumor of the kidney: A case report and review of the literature. ( 23599785 )
2013
37
Metanephric adenoma: A report of two cases and review of the literature. ( 24649298 )
2013
38
A case of a metanephric adenoma of the kidney surgically treated with robot-assisted laparoscopic partial nephrectomy. ( 24171133 )
2013
39
Adult nephroblastoma with predominant epithelial component: a differential diagnostic candidate of papillary renal cell carcinoma and metanephric adenoma-report of three cases. ( 24083046 )
2013
40
Metanephric adenoma: a case report and review of the literature. ( 24029279 )
2013
41
BRAF mutations in metanephric adenoma of the kidney. ( 22727996 )
2012
42
Bilateral, multicenteric metanephric adenoma associated with Wilms' tumor in a child: a rare presentation with important diagnostic and therapeutic implications. ( 22925468 )
2012
43
A case of central metanephric adenoma successfully treated with laparoscopic nephron-sparing surgery. ( 22705110 )
2012
44
CT and ultrasound findings of metanephric adenoma: a report of two cases and literature review. ( 21325357 )
2011
45
Metanephric Adenoma: clinical, imaging, and Histological findings. ( 21484060 )
2011
46
Conservative treatment of metanephric adenoma. A case report and review of the literature. ( 21220212 )
2011
47
Metanephric adenoma of the kidney: an unusual diagnostic challenge. ( 21139840 )
2010
48
Metanephric adenoma in a 2-year-old child: case report and immunohistochemical observations. ( 20539237 )
2010
49
Metanephric adenoma of the kidney: clinical and radiological study of nine cases. ( 19220269 )
2009
50
Metanephric adenoma in a two-year-old child. ( 19641372 )
2009

Variations for Metanephric Adenoma

Cosmic variations for Metanephric Adenoma:

9
(show top 50) (show all 576)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM5012058 ZNF462 kidney,NS,carcinoma,papillary renal cell carcinoma c.7085G>A p.R2362Q 9:107003322-107003322 3
2 COSM5010682 ZNF281 kidney,NS,carcinoma,papillary renal cell carcinoma c.2093C>T p.P698L 1:200407613-200407613 3
3 COSM5013462 ZNF225 kidney,NS,carcinoma,papillary renal cell carcinoma c.1187G>T p.G396V 19:44131801-44131801 3
4 COSM5011020 ZNF142 kidney,NS,carcinoma,papillary renal cell carcinoma c.3322G>T p.D1108Y 2:218642705-218642705 3
5 COSM6934293 ZFHX3 kidney,NS,carcinoma,papillary renal cell carcinoma c.2590T>C p.Y864H 16:72957556-72957556 3
6 COSM5014655 ZBTB2 kidney,NS,carcinoma,papillary renal cell carcinoma c.931G>A p.E311K 6:151366135-151366135 3
7 COSM5012645 XPO4 kidney,NS,carcinoma,papillary renal cell carcinoma c.1218C>A p.F406L 13:20809842-20809842 3
8 COSM6916551 XPO1 kidney,NS,carcinoma,papillary renal cell carcinoma c.259A>G p.I87V 2:61522653-61522653 3
9 COSM2888871 XKR7 kidney,NS,carcinoma,papillary renal cell carcinoma c.1409C>T p.T470M 20:31997126-31997126 3
10 COSM6941466 XIAP kidney,NS,carcinoma,renal cell carcinoma c.563G>C p.G188A 23:123886225-123886225 3
11 COSM5012777 WDR89 kidney,NS,carcinoma,papillary renal cell carcinoma c.260C>A p.S87* 14:63599683-63599683 3
12 COSM17807 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.264G>C p.W88C 3:10142111-10142111 3
13 COSM14312 VHL kidney,NS,carcinoma,renal cell carcinoma c.353T>C p.L118P 3:10146526-10146526 3
14 COSM18070 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.263G>A p.W88* 3:10142110-10142110 3
15 COSM14380 VHL kidney,NS,carcinoma,renal cell carcinoma c.548C>A p.S183* 3:10149871-10149871 3
16 COSM18350 VHL kidney,NS,carcinoma,renal cell carcinoma c.256C>T p.P86S 3:10142103-10142103 3
17 COSM18346 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.341G>C p.G114A 3:10146514-10146514 3
18 COSM17957 VHL kidney,NS,carcinoma,renal cell carcinoma c.292T>G p.Y98D 3:10142139-10142139 3
19 COSM14382 VHL kidney,NS,carcinoma,renal cell carcinoma c.245G>C p.R82P 3:10142092-10142092 3
20 COSM14305 VHL kidney,NS,carcinoma,renal cell carcinoma c.266T>A p.L89H 3:10142113-10142113 3
21 COSM17917 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.523T>G p.Y175D 3:10149846-10149846 3
22 COSM25670 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.556G>T p.E186* 3:10149879-10149879 3
23 COSM25676 VHL kidney,NS,carcinoma,renal cell c.485G>T p.C162F 3:10149808-10149808 3
24 COSM17875 VHL kidney,NS,carcinoma,renal cell carcinoma c.234T>G p.N78K 3:10142081-10142081 3
25 COSM14311 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.499C>T p.R167W 3:10149822-10149822 3
26 COSM17983 VHL kidney,NS,carcinoma,renal cell carcinoma c.500G>A p.R167Q 3:10149823-10149823 3
27 COSM18097 VHL kidney,NS,carcinoma,renal cell carcinoma c.482G>A p.R161Q 3:10149805-10149805 3
28 COSM14425 VHL kidney,NS,carcinoma,renal cell carcinoma c.341-2A>T p.? 3:10146512-10146512 3
29 COSM17808 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.443T>C p.F148S 3:10146616-10146616 3
30 COSM30286 VHL kidney,NS,carcinoma,papillary renal cell carcinoma c.473T>G p.L158R 3:10149796-10149796 3
31 COSM17872 VHL kidney,NS,carcinoma,renal cell carcinoma c.217C>T p.Q73* 3:10142064-10142064 3
32 COSM5015677 VAPB kidney,NS,carcinoma,papillary renal cell carcinoma c.149G>A p.R50H 20:58418301-58418301 3
33 COSM30316 USP24 kidney,NS,carcinoma,papillary renal cell carcinoma c.5867A>G p.Y1956C 1:55095342-55095342 3
34 COSM5011185 UROC1 kidney,NS,carcinoma,papillary renal cell carcinoma c.401A>G p.N134S 3:126508426-126508426 3
35 COSM27269 UMPS kidney,NS,carcinoma,renal cell c.528G>A p.L176L 3:124737785-124737785 3
36 COSM30400 UBR4 kidney,NS,carcinoma,papillary renal cell carcinoma c.8588C>T p.A2863V 1:19140793-19140793 3
37 COSM5015711 TXNRD2 kidney,NS,carcinoma,papillary renal cell carcinoma c.1017G>T p.Q339H 22:19883394-19883394 3
38 COSM6980319 TSC2 kidney,NS,carcinoma,papillary renal cell carcinoma c.512G>C p.G171A 16:2055432-2055432 3
39 COSM6957851 TSC2 kidney,NS,carcinoma,renal cell carcinoma c.541G>A p.V181M 16:2055461-2055461 3
40 COSM6942356 TSC1 kidney,NS,carcinoma,renal cell carcinoma c.2287C>T p.Q763* 9:132902709-132902709 3
41 COSM6963117 TSC1 kidney,NS,carcinoma,renal cell carcinoma c.1001C>A p.S334* 9:132911481-132911481 3
42 COSM29770 TSC1 kidney,NS,carcinoma,renal cell carcinoma c.508+1G>T p.? 9:132923347-132923347 3
43 COSM5017221 TRRAP kidney,NS,carcinoma,papillary renal cell carcinoma c.5182A>G p.I1728V 7:98950185-98950185 3
44 COSM30474 TRIO kidney,NS,carcinoma,renal cell c.9008A>G p.N3003S 5:14508136-14508136 3
45 COSM10656 TP53 kidney,NS,carcinoma,renal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 3
46 COSM45243 TP53 kidney,NS,carcinoma,renal cell carcinoma c.374C>G p.T125R 17:7675995-7675995 3
47 COSM10647 TP53 kidney,NS,carcinoma,renal cell carcinoma c.404G>T p.C135F 17:7675208-7675208 3
48 COSM43697 TP53 kidney,NS,carcinoma,papillary renal cell carcinoma c.832C>A p.P278T 17:7673788-7673788 3
49 COSM44310 TP53 kidney,NS,carcinoma,renal cell carcinoma c.738G>A p.M246I 17:7674225-7674225 3
50 COSM6922197 TP53 kidney,NS,carcinoma,renal cell carcinoma c.97-2A>C p.? 17:7676274-7676274 3

Copy number variations for Metanephric Adenoma from CNVD:

7 (show all 34)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13793 1 1 51300000 Gain Metanephric adenoma
2 24331 1 178600000 205300000 Loss Metanephric adenoma
3 43851 10 50100000 71300000 Loss Metanephric adenoma
4 56500 11 59700000 70700000 Gain Metanephric adenoma
5 56501 11 59700000 74900000 Gain Metanephric adenoma
6 67783 12 44600000 61400000 Gain Metanephric adenoma
7 69822 12 56300000 94800000 Loss Metanephric adenoma
8 70920 12 66000000 91200000 Loss Metanephric adenoma
9 78014 13 48900000 97000000 Loss Metanephric adenoma
10 84882 14 35600000 52300000 Loss Metanephric adenoma
11 97247 16 1 34400000 Gain Metanephric adenoma
12 106743 17 1 11200000 Gain Metanephric adenoma
13 109764 17 28800000 47600000 Gain Metanephric adenoma
14 109766 17 28800000 78774742 Gain Metanephric adenoma
15 119821 18 17300000 76117153 Loss Metanephric adenoma
16 124073 19 1 19800000 Gain Metanephric adenoma
17 124091 19 1 26700000 Gain Metanephric adenoma
18 127805 19 37100000 57600000 Gain Metanephric adenoma
19 127807 19 37100000 63811651 Gain Metanephric adenoma
20 157127 21 13200000 34700000 Loss Metanephric adenoma
21 160311 22 11800000 49691432 Gain Metanephric adenoma
22 160871 22 16300000 47000000 Gain Metanephric adenoma
23 178372 3 71800000 91700000 Loss Metanephric adenoma
24 187565 4 52400000 187300000 Loss Metanephric adenoma
25 191443 5 1 135400000 Loss Metanephric adenoma
26 209384 6 26100000 45200000 Gain Metanephric adenoma
27 218055 7 107200000 126900000 Loss Metanephric adenoma
28 227757 7 71800000 97900000 Loss Metanephric adenoma
29 228540 7 77400000 126900000 Loss Metanephric adenoma
30 240253 8 48100000 146274826 Loss Metanephric adenoma
31 246807 9 125800000 140273252 Gain Metanephric adenoma
32 253828 9 4600000 36300000 Loss Metanephric adenoma
33 257105 X 1 154913754 Loss Metanephric adenoma
34 264059 X 59500000 154913754 Loss Metanephric adenoma

Expression for Metanephric Adenoma

Search GEO for disease gene expression data for Metanephric Adenoma.

Pathways for Metanephric Adenoma

Pathways related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.62 KRT18 KRT7 VIM
2 11.02 VIM WT1
3
Show member pathways
10.83 KRT18 KRT7 VIM

GO Terms for Metanephric Adenoma

Cellular components related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 AMACR BRAF KANK1 KRT18 KRT7 VIM
2 intermediate filament GO:0005882 8.8 KRT18 KRT7 VIM

Biological processes related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.13 KRT18 KRT7 VIM
2 negative regulation of neuron projection development GO:0010977 8.62 KANK1 VIM

Molecular functions related to Metanephric Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT18 VIM
2 structural molecule activity GO:0005198 8.8 KRT18 KRT7 VIM

Sources for Metanephric Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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44 MeSH
45 MESH via Orphanet
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49 NCI
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54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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