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MCID: MTH071
MIFTS: 25

Methane Production

Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Methane Production

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MalaCards integrated aliases for Methane Production:

Name: Methane Production 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
unclear
? autosomal recessive


HPO:

31
methane production:
Inheritance autosomal recessive inheritance


External Ids:

OMIM® 57 250650
MedGen 41 C1855163
SNOMED-CT via HPO 68 258211005 363406005
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Summaries for Methane Production

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MalaCards based summary : Methane Production is related to constipation and rapidly involuting congenital hemangioma. An important gene associated with Methane Production is ALB (Albumin). The drugs Neomycin and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow, and related phenotypes are colon cancer and abnormal abdomen morphology

More information from OMIM: 250650
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Related Diseases for Methane Production

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Diseases related to Methane Production via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 constipation 10.5
2 rapidly involuting congenital hemangioma 10.4
3 irritable bowel syndrome 10.3
4 overgrowth syndrome 10.3
5 diarrhea 10.2
6 triiodothyronine receptor auxiliary protein 10.1
7 48,xyyy 10.1
8 47,xyy 10.0
9 anoxia 10.0
10 hair whorl 9.9
11 cystic fibrosis 9.9
12 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
13 helicobacter pylori infection 9.9
14 body mass index quantitative trait locus 1 9.9
15 myelomeningocele 9.9
16 urinary tract infection 9.9
17 mastitis 9.9
18 methemoglobinemia 9.9
19 acute cystitis 9.9
20 neurogenic bowel 9.9
21 gastrointestinal system disease 9.9
22 ulcerative colitis 9.9
23 crohn's disease 9.9
24 heavy metal poisoning 9.9
25 acute sensory ataxic neuropathy 9.9

Graphical network of the top 20 diseases related to Methane Production:



Diseases related to Methane Production
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Symptoms & Phenotypes for Methane Production

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Human phenotypes related to Methane Production:

31
# Description HPO Frequency HPO Source Accession
1 colon cancer 31 HP:0003003
2 abnormal abdomen morphology 31 HP:0001438

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
G I:
methane production by colonic flora

Respiratory:
methane excretion
increased methane excretion with colon cancer

Clinical features from OMIM®:

250650 (Updated 05-Mar-2021)

Sources

Drugs & Therapeutics for Methane Production

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Drugs for Methane Production (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved Early Phase 1 1404-04-2 8378
2
Rifaximin Approved, Investigational Early Phase 1 80621-81-4 6436173 46783403
3 Gastrointestinal Agents Early Phase 1
4 Anti-Infective Agents Early Phase 1
5 Anti-Bacterial Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multi-Dose Study of the Effect of Two Dosage Strengths of SYN-010 Compared With Placebo on Breath Methane Production in Breath Methane-Positive Subjects With IBS-C Completed NCT02495623 Phase 2 SYN-010 21 mg;SYN-010 42 mg;Placebo
2 Methane Production and Glycemic Regulation in Pre-diabetic Subjects: Role of Methane in Glycemic Control Completed NCT01638429 Early Phase 1 Neomycin;Rifaximin

Search NIH Clinical Center for Methane Production

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Genetic Tests for Methane Production

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Anatomical Context for Methane Production

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MalaCards organs/tissues related to Methane Production:

40
Colon, Small Intestine, Bone Marrow, Bone, Liver, Breast
Sources

Publications for Methane Production

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Articles related to Methane Production:

(show top 50) (show all 4530)
# Title Authors PMID Year
1
Flatulence. 57
6772089 1980
2
Breath-methane in patients with cancer of the large bowel. 57
70691 1977
3
Floating stools--flatus versus fat. 57
5015442 1972
4
Factors influencing pulmonary methane excretion in man. An indirect method of studying the in situ metabolism of the methane-producing colonic bacteria. 57
5111441 1971
5
Volume, composition, and source of intestinal gas. 57
5486278 1970
6
Functions of bacteria and archaea participating in the bioconversion of organic waste for methane production. 61
33229086 2021
7
Enhancing methane production from dewatered waste activated sludge through alkaline and photocatalytic pretreatment. 61
33493745 2021
8
Optimization of a newly developed electromethanogenesis for the highest record of methane production. 61
33199142 2021
9
Explore the difference between the single-chamber and dual-chamber microbial electrosynthesis for biogas production performance. 61
33421897 2021
10
Temporary addition of carbon fibers facilitates methanogenic degradation of ethanol during anaerobic treatment. 61
33082040 2021
11
Effect of co-digestion of tylosin fermentation dreg and food waste on anaerobic digestion performance. 61
33465646 2021
12
Effects of anaerobic granular sludge towards the treatment of flowback water in an up-flow anaerobic sludge blanket bioreactor: Comparison between mesophilic and thermophilic conditions. 61
33548817 2021
13
Operationalization of a microbial electrolysis cell: The interaction of the primary factors for energy storage efficiency. 61
33561662 2021
14
Enrichment of salt-tolerant CO2-fixing communities in microbial electrosynthesis systems using porous ceramic hollow tube wrapped with carbon cloth as cathode and for CO2 supply. 61
33077225 2021
15
Effect of ammonia removal and biochar detoxification on anaerobic digestion of aqueous phase from municipal sludge hydrothermal liquefaction. 61
33548815 2021
16
Improved stability of up-flow anaerobic sludge blanket reactor treating starch wastewater by pre-acidification: Impact on microbial community and metabolic dynamics. 61
33540215 2021
17
Improving anaerobic digestion of chicken manure under optimized biochar supplementation strategies. 61
33461122 2021
18
Rapid recovery of methane yield in organic overloaded-failed anaerobic digesters through bioaugmentation with acclimatized microbial consortium. 61
33421748 2021
19
Enhanced anaerobic digestion with the addition of chelator-nickel complexes to improve nickel bioavailability. 61
33246732 2021
20
Carbon cloth facilitates semi-continuous anaerobic digestion of organic wastewater rich in volatile fatty acids from dark fermentation. 61
33257151 2021
21
Enhancing methane production of synthetic brewery water with granular activated carbon modified with nanoscale zero-valent iron (NZVI) in anaerobic system. 61
33341639 2021
22
Enhanced energy recovery via separate hydrogen and methane production from two-stage anaerobic digestion of food waste with nanobubble water supplementation. 61
33162132 2021
23
Effect of biochar addition on microbial community and methane production during anaerobic digestion of food wastes: The role of minerals in biochar. 61
33385628 2021
24
Enhanced methane production in an up-flow microbial electrolysis assisted reactors: Hydrodynamics characteristics and electron balance under different spatial distributions of bioelectrodes. 61
33454649 2021
25
Enhanced phenols removal and methane production with the assistance of graphene under anaerobic co-digestion conditions. 61
33223184 2021
26
Coupling hydrothermal carbonization and anaerobic digestion for sewage digestate management: Influence of hydrothermal treatment time on dewaterability and bio-methane production. 61
33401118 2021
27
A sodium percarbonate/ultraviolet system generated free radicals for degrading capsaicin to alleviate inhibition of methane production during anaerobic digestion of lipids and food waste. 61
33160666 2021
28
Biodegradation of creosote-treated wood by two novel constructed microbial consortia for the enhancement of methane production. 61
33360721 2021
29
Coupling granular activated carbon and exogenous hydrogen to enhance anaerobic digestion of phenol via predominant syntrophic acetate oxidation and hydrogenotrophic methanogenesis pathway. 61
33401163 2021
30
Effect of static magnetic field on microbial community during anaerobic digestion. 61
33373801 2021
31
Ferroferric oxide promotes metabolism in Anaerolineae other than microbial syntrophy in anaerobic methanogenesis of antibiotic fermentation residue. 61
33261864 2021
32
Optimization of Chlamydomonas reinhardtii cultivation with simultaneous CO2 sequestration and biofuels production in a biorefinery framework. 61
33162147 2021
33
Enhanced lignocellulosic component removal and biomethane potential from chestnut shell by a combined hydrothermal-alkaline pretreatment. 61
33360342 2021
34
Metagenomic analysis reveals the fate of antibiotic resistance genes in two-stage and one-stage anaerobic digestion of waste activated sludge. 61
33302189 2021
35
Thermal pre-treatment: Getting some insights on the formation of recalcitrant compounds and their effects on anaerobic digestion. 61
33445137 2021
36
Two-Stage anaerobic digestion in agroindustrial waste treatment: A review. 61
33360925 2021
37
Continuous recovery and enhanced yields of volatile fatty acids from a continually-fed 100 L food waste bioreactor by filtration and electrodialysis. 61
33494002 2021
38
Biodegradation of hydrophobic pesticides by microalgae: Transformation products and impact on algae biochemical methane potential. 61
32911153 2021
39
Variable sediment methane production in response to different source-associated sewer sediment types and hydrological patterns: Role of the sediment microbiome. 61
33296733 2021
40
Comparative assessment of pre- and inter-stage hydrothermal treatment of municipal sludge for increased methane production. 61
33523520 2021
41
Thermophilic anaerobic digestion of winery effluents in a two-stage process and the effect of the feeding frequency on methane production. 61
33592509 2021
42
Optimization and comparison of methane production and residual characteristics in mesophilic anaerobic digestion of sewage sludge by hydrothermal treatment. 61
33038733 2021
43
Valorisation of bioethanol production residues through anaerobic digestion: Methane production and microbial communities. 61
33571777 2021
44
Enrichment of waste sewage sludge for enhancing methane production from cellulose. 61
33307481 2021
45
Anaerobic co-digestion of chicken manure and cardboard waste: Focusing on methane production, microbial community analysis and energy evaluation. 61
33285504 2021
46
Effective methane production from the Japanese weed Gyougi-shiba (Cynodon dactylon) is accomplished by colocalization of microbial communities that assimilate water-soluble and -insoluble fractions. 61
33587116 2021
47
Variation of volatile fatty acid oxidation and methane production during the bioaugmentation of anaerobic digestion system: Microbial community analysis revealing the influence of microbial interactions on metabolic pathways. 61
33254934 2021
48
Impact of metallic nanoparticles on anaerobic digestion: A systematic review. 61
33257063 2021
49
Effects of pH on ex-situ biomethanation with hydrogenotrophic methanogens under thermophilic and extreme-thermophilic conditions. 61
33199191 2021
50
Performance prediction of ZVI-based anaerobic digestion reactor using machine learning algorithms. 61
33360168 2021
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Variations for Methane Production

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Expression for Methane Production

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Search GEO for disease gene expression data for Methane Production.
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Pathways for Methane Production

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GO Terms for Methane Production

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Sources for Methane Production

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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