MCID: MTH047
MIFTS: 32

Methanol Poisoning

Categories: Rare diseases

Aliases & Classifications for Methanol Poisoning

MalaCards integrated aliases for Methanol Poisoning:

Name: Methanol Poisoning 59

Characteristics:

Orphanet epidemiological data:

59
methanol poisoning
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Orphanet 59 ORPHA31825
ICD10 via Orphanet 34 T51.1

Summaries for Methanol Poisoning

MalaCards based summary : Methanol Poisoning is related to metabolic acidosis and retinitis. An important gene associated with Methanol Poisoning is ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Epoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and testes.

Related Diseases for Methanol Poisoning

Diseases related to Methanol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 metabolic acidosis 10.2
2 retinitis 10.1
3 peritonitis 10.0
4 fetal alcohol syndrome 10.0 ADH1B AKR1A1
5 aspartylglucosaminuria 9.9 ADH1B ADH1C
6 multiple sclerosis 9.8
7 3-methylglutaconic aciduria, type iii 9.8
8 oromandibular dystonia 9.8
9 ischemia 9.8
10 cerebritis 9.8
11 hyperglycemia 9.8
12 pancreatitis 9.8
13 dystonia 9.8
14 alcohol abuse 9.6 AKR1A1 CYP2E1
15 alcoholic pancreatitis 9.6 ADH1B CYP2E1
16 liver cirrhosis 9.2 ADH1B CYP2E1
17 alcoholic liver cirrhosis 9.2 ADH1B ADH1C CYP2E1
18 alcohol dependence 7.7 ADH1A ADH1B ADH1C ADH5 AKR1A1 CYP2E1

Graphical network of the top 20 diseases related to Methanol Poisoning:



Diseases related to Methanol Poisoning

Symptoms & Phenotypes for Methanol Poisoning

Drugs & Therapeutics for Methanol Poisoning

Drugs for Methanol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Epoetin alfa Phase 3 113427-24-0
2 Hematinics Phase 3
3
Fomepizole Approved, Vet_approved 7554-65-6 3406
4 Antidotes
5 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Recruiting NCT02376881 Phase 3 Erythropoietin
2 Specified Drug-use Survey of Fomepizole Intravenous Infusion (All-case Surveillance) Recruiting NCT02415712 Fomepizole

Search NIH Clinical Center for Methanol Poisoning

Genetic Tests for Methanol Poisoning

Anatomical Context for Methanol Poisoning

MalaCards organs/tissues related to Methanol Poisoning:

41
Brain, Liver, Testes, Retina, Whole Blood

Publications for Methanol Poisoning

Articles related to Methanol Poisoning:

(show top 50) (show all 247)
# Title Authors Year
1
Role of activation of lipid peroxidation in the mechanisms of acute methanol poisoning<sup/>. ( 29607701 )
2018
2
The Hypothesis of Circulus Hypoxicus and Its Clinical Relevance in Patients with Methanol Poisoning - an Observational Study of 35 Patients. ( 29923671 )
2018
3
Methanol poisoning by solvent inhalation. ( 29859671 )
2018
4
Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans. ( 29968299 )
2018
5
Severe methanol poisoning with neurological sequelae: implications for diagnosis and management. ( 29512320 )
2018
6
Gait and Balance Impairment after Acute Methanol Poisoning. ( 28724204 )
2017
7
Methanol poisoning: 27 years experience at a tertiary care hospital. ( 29171574 )
2017
8
Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks. ( 28730555 )
2017
9
Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning. ( 27817225 )
2017
10
Leukotriene-mediated neuroinflammation, toxic brain damage, and neurodegeneration in acute methanol poisoning. ( 28165820 )
2017
11
Cognitive sequelae of methanol poisoning involve executive dysfunction and memory impairment in cross-sectional and long-term perspective. ( 28262185 )
2017
12
Importance of GAP anion in the absence of clinical information: Description of one clinical case of severe oral methanol poisoning. ( 28073512 )
2017
13
Positive serum ethanol concentration on admission to hospital as the factor predictive of treatment outcome in acute methanol poisoning. ( 28344362 )
2017
14
Homicidal methanol poisoning in filicide-suicide. ( 29210340 )
2017
15
Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak. ( 28291652 )
2017
16
Neurological Complications Resulting from Non-Oral Occupational Methanol Poisoning. ( 28049252 )
2017
17
Teaching neuroimages: 'Blind drunk': neuroimaging findings in methanol poisoning. ( 26811094 )
2016
18
Transdermal Spirit (Methanol) Poisoning: A Case Report. ( 28191327 )
2016
19
Correction: The Methanol Poisoning Outbreaks in Libya 2013 and Kenya 2014. ( 27257672 )
2016
20
The Methanol Poisoning Outbreaks in Libya 2013 and Kenya 2014. ( 27030969 )
2016
21
Acute methanol poisoning: Prevalence and predisposing factors of haemorrhagic and non-haemorrhagic brain lesions. ( 26806851 )
2016
22
Visual evoked potentials in patients after methanol poisoning. ( 26988885 )
2016
23
Haemorrhagic putaminal necrosis, optic atrophy and coma: a triad suggestive of methanol poisoning. ( 27608349 )
2016
24
Cupping of the optic disk after methanol poisoning. ( 25777817 )
2015
25
Bibliometric profile of the global scientific research on methanol poisoning (1902-2012). ( 25949270 )
2015
26
A novel bedside diagnostic test for methanol poisoning using dry chemistry for formate. ( 26203958 )
2015
27
A case of methanol poisoning leading to prolonged respirator dependency with consequent blindness and irreversible brain damage. ( 26644889 )
2015
28
Fomepizole versus ethanol in the treatment of acute methanol poisoning: Comparison of clinical effectiveness in a mass poisoning outbreak. ( 26109326 )
2015
29
Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. ( 25493973 )
2015
30
Prediction and validation of hemodialysis duration in acute methanol poisoning. ( 26244924 )
2015
31
Fluctuations in serum ethanol concentration in the treatment of acute methanol poisoning: a prospective study of 21 patients. ( 25732977 )
2015
32
A drink to die for: Arak and methanol poisoning in Indonesia. ( 26612046 )
2015
33
Visual and neurologic sequelae of methanol poisoning in Saudi Arabia. ( 25935177 )
2015
34
CYP2E1 Polymorphism and better outcome after methanol poisoning. ( 25891966 )
2015
35
Severe Methanol Poisoning with Supralethal Serum Formate Concentration: A Case Report. ( 26380973 )
2015
36
Prioritizing the intoxicated patients for extracorporeal treatments in methanol poisoning. ( 25978174 )
2015
37
Rare Alleles within the CYP2E1 (MEOS System) Could be Associated with Better Short-Term Health Outcome after Acute Methanol Poisoning. ( 25146350 )
2014
38
A case of methanol poisoning in a child. ( 24711938 )
2014
39
A singular case of survival after acute methanol poisoning: toxicological and neuroimaging findings. ( 25354223 )
2014
40
Risk factors for mortality in Asian Taiwanese patients with methanol poisoning. ( 24465131 )
2014
41
Unusual cause of spontaneous unilateral intracerebral hematoma-acute methanol poisoning: case report. ( 24674109 )
2014
42
Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning. ( 24621917 )
2014
43
Is the Measurement of Serum Formate Concentration Useful in the Diagnostics of Acute Methanol Poisoning? A Prospective Study of 38 Patients. ( 25308806 )
2014
44
Forgoing the Folate?-Contemporary Recommendations for Methanol Poisoning and Evidence Review. ( 24531405 )
2014
45
Viewpoint: Methanol poisoning outbreak in Libya: A need for policy reforms. ( 24831674 )
2014
46
Electrocardiographic manifestations in acute methanol poisoning. ( 25470191 )
2014
47
Methanol poisoning with blindness and putaminal necrosis - was metabolic acidosis missed? ( 24625950 )
2014
48
What's new in Emergencies, Trauma and Shock? Studying the clinical and biochemical correlates in methanol poisoning. ( 23723612 )
2013
49
Magnetic resonance imaging and computed tomography scan findings in methanol poisoning. ( 24339634 )
2013
50
Response to the letter &amp;quot;Risk assessment of methanol poisoning in outbreaks not applicable to isolated cases&amp;quot;. ( 23339630 )
2013

Variations for Methanol Poisoning

Expression for Methanol Poisoning

Search GEO for disease gene expression data for Methanol Poisoning.

Pathways for Methanol Poisoning

Pathways related to Methanol Poisoning according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 ADH1A ADH1B ADH1C ADH5 AKR1A1 ALDH1L1
2
Show member pathways
12.88 ADH1A ADH1B ADH1C ADH5 AKR1A1 CYP2E1
3
Show member pathways
12.52 ADH1A ADH1B ADH1C ADH5 CYP2E1
4
Show member pathways
12.35 ADH1A ADH1B ADH1C ADH5 AKR1A1
5
Show member pathways
11.93 ADH1B AKR1A1 CYP2E1
6
Show member pathways
11.59 ADH1A ADH1B ADH1C ADH5
7 11.52 ADH1C ADH5
8
Show member pathways
11.37 ADH1A ADH1C
9
Show member pathways
11.34 ADH1A ADH1B ADH1C ADH5
10 11.18 ADH1A CYP2E1
11 10.9 AKR1A1 CYP2E1
12
Show member pathways
10.67 ADH1B CYP2E1
13 10.55 ADH1A ADH1B ADH1C
14
Show member pathways
10.51 ADH1A ADH1B ADH1C ADH5 AKR1A1
15
Show member pathways
10.5 ADH1B CYP2E1
16
Show member pathways
10.09 ADH5 ALDH1L1 CYP2E1

GO Terms for Methanol Poisoning

Cellular components related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.1 ADH1A ADH1B ADH1C ADH5 AKR1A1 ALDH1L1

Biological processes related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.5 ADH1A ADH1B ADH1C ADH5 AKR1A1 ALDH1L1
2 electron transport chain GO:0022900 9.26 ADH5 AKR1A1
3 drug metabolic process GO:0017144 9.16 ADH1A CYP2E1
4 ethanol oxidation GO:0006069 8.92 ADH1A ADH1B ADH1C ADH5

Molecular functions related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.62 ADH1A ADH1B ADH1C ADH5
2 electron transfer activity GO:0009055 9.37 ADH5 AKR1A1
3 alcohol dehydrogenase (NAD) activity GO:0004022 9.33 ADH1A ADH1C ADH5
4 retinol dehydrogenase activity GO:0004745 9.26 ADH1A ADH1C
5 oxidoreductase activity GO:0016491 9.17 ADH1A ADH1B ADH1C ADH5 AKR1A1 ALDH1L1
6 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.13 ADH1A ADH1B ADH1C

Sources for Methanol Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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