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MCID: MTH047
MIFTS: 34

Methanol Poisoning

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Methanol Poisoning

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MalaCards integrated aliases for Methanol Poisoning:

Name: Methanol Poisoning 58

Characteristics:

Orphanet epidemiological data:

58
methanol poisoning
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 via Orphanet 33 T51.1
Orphanet 58 ORPHA31825
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Summaries for Methanol Poisoning

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MalaCards based summary : Methanol Poisoning is related to alcohol use disorder and alcoholic liver cirrhosis. An important gene associated with Methanol Poisoning is AKR1A1 (Aldo-Keto Reductase Family 1 Member A1), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Hematinics and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and globus pallidus, and related phenotypes are type ii diabetes mellitus and seizures

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Related Diseases for Methanol Poisoning

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Diseases related to Methanol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 alcohol use disorder 28.5 CYP2E1 ALDH2 AKR1A1 ADH1C ADH1B
2 alcoholic liver cirrhosis 27.9 CYP2E1 ALDH2 AKR1A1 ADH1C ADH1B
3 liver cirrhosis 27.9 CYP2E1 ALDH2 AKR1A1 ADH1C ADH1B
4 alcohol dependence 27.1 CYP2E1 ALDH2 AKR1A1 ADH5 ADH1C ADH1B
5 metabolic acidosis 10.8
6 ocular motor apraxia 10.6
7 yemenite deaf-blind hypopigmentation syndrome 10.6
8 optic nerve disease 10.4
9 3-methylglutaconic aciduria, type iii 10.3
10 covid-19 10.3
11 ethylene glycol poisoning 10.3
12 neuropathy 10.2
13 tremor 10.2
14 ataxia and polyneuropathy, adult-onset 10.1
15 toxic optic neuropathy 10.1
16 polyneuropathy 10.1
17 hyperglycemia 10.1
18 hypoglycemia 10.1
19 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
20 aspiration pneumonia 10.1
21 acute pancreatitis 10.1
22 lactic acidosis 10.1
23 peripheral nervous system disease 10.1
24 subacute delirium 10.1
25 pathologic nystagmus 10.1
26 headache 10.1
27 cystic fibrosis 9.9
28 lymphangioleiomyomatosis 9.9
29 pulmonary disease, chronic obstructive 9.9
30 oromandibular dystonia 9.9
31 myoglobinuria 9.9
32 amnestic disorder 9.9
33 respiratory failure 9.9
34 optic neuritis 9.9
35 renal tubular acidosis 9.9
36 papilledema 9.9
37 neuritis 9.9
38 ischemia 9.9
39 thrombophlebitis 9.9
40 retrograde amnesia 9.9
41 dystonia 9.9
42 kidney disease 9.9
43 scotoma 9.9
44 48,xyyy 9.9
45 anton's syndrome 9.9
46 encephalopathy 9.9
47 head injury 9.9
48 posttransplant acute limbic encephalitis 9.9
49 hypocalcemia, autosomal dominant 1 9.9 ADH1B ADH1A
50 focal dermal hypoplasia 9.8 ALDH1L1 ADH5

Graphical network of the top 20 diseases related to Methanol Poisoning:



Diseases related to Methanol Poisoning
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Symptoms & Phenotypes for Methanol Poisoning

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Human phenotypes related to Methanol Poisoning:

58 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 type ii diabetes mellitus 58 Occasional (29-5%)
2 seizures 58 Very rare (<4-1%)
3 visual impairment 58 Frequent (79-30%)
4 blindness 58 Occasional (29-5%)
5 vomiting 58 Occasional (29-5%)
6 type i diabetes mellitus 58 Very rare (<4-1%)
7 myocardial infarction 58 Occasional (29-5%)
8 abdominal pain 58 Occasional (29-5%)
9 hypertension 58 Frequent (79-30%)
10 hyperlipidemia 58 Frequent (79-30%)
11 intracranial hemorrhage 58 Frequent (79-30%)
12 cerebral hemorrhage 58 Very rare (<4-1%)
13 metabolic acidosis 58 Very frequent (99-80%)
14 diarrhea 58 Occasional (29-5%)
15 abnormality of the cerebral white matter 58 Occasional (29-5%)
16 confusion 58 Occasional (29-5%)
17 coma 58 Occasional (29-5%)
18 abnormality of the optic nerve 58 Occasional (29-5%)
19 blurred vision 58 Frequent (79-30%)
20 abnormal corpus callosum morphology 58 Occasional (29-5%)
21 abnormal caudate nucleus morphology 58 Very rare (<4-1%)
22 bilateral basal ganglia lesions 58 Occasional (29-5%)
23 abnormal globus pallidus morphology 58 Occasional (29-5%)
24 abnormal morphology of the cerebellar cortex 58 Very rare (<4-1%)
25 abnormal putamen morphology 58 Frequent (79-30%)
26 alcoholism 58 Frequent (79-30%)
27 basal ganglia necrosis 58 Occasional (29-5%)
28 permanent atrial fibrillation 58 Very rare (<4-1%)
29 inflammatory arteriopathy 58 Very rare (<4-1%)
Sources

Drugs & Therapeutics for Methanol Poisoning

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Drugs for Methanol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hematinics Phase 3
2 Epoetin alfa Phase 3 113427-24-0
3
Fomepizole Approved, Vet_approved 7554-65-6 3406
4 Antidotes
5 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Erythropoietin in Methanol Associated Optic Neuropathy Active, not recruiting NCT02376881 Phase 3 Erythropoietin
2 Specified Drug-use Survey of Fomepizole Intravenous Infusion "Takeda" (All-case Surveillance) Recruiting NCT02415712 Fomepizole
3 Red Cell Distribution Width as a Predictor of Mortality in Acute Methanol Poisoning Not yet recruiting NCT04064801

Search NIH Clinical Center for Methanol Poisoning

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Genetic Tests for Methanol Poisoning

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Anatomical Context for Methanol Poisoning

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MalaCards organs/tissues related to Methanol Poisoning:

40
Brain, Retina, Globus Pallidus, Cortex, Kidney, Liver, Caudate Nucleus
Sources

Publications for Methanol Poisoning

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Articles related to Methanol Poisoning:

(show top 50) (show all 558)
# Title Authors PMID Year
1
Analysis of fomepizole safety based on a 16-year post-marketing experience in France. 61
31608703 2020
2
MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning. 61
32554081 2020
3
Status of clinical toxicology education and ethics in medical care of poisoned patients in the Islamic Republic of Iran and a comparison with other countries. 61
31863569 2020
4
Comment on consensus statements on the approach to patients in a methanol poisoning outbreak. 61
31496310 2020
5
Toll of acute methanol poisoning for preventing COVID-19. 61
32462212 2020
6
New Methanol Poisoning Outbreaks in Iran Following COVID-19 Pandemic. 61
32400874 2020
7
A Syndemic of COVID-19 and methanol poisoning in Iran: Time for Iran to consider alcohol use as a public health challenge? 61
32505493 2020
8
Peripheral polyneuropathy after acute methanol poisoning: Six-year prospective cohort study. 61
32380190 2020
9
A Surge in Methanol Poisoning Amid COVID-19 Pandemic: Why Is This Occurring? 61
32536420 2020
10
Methanol Poisoning Emerging as the Result of COVID-19 Outbreak; Radiologic Perspective. 61
32273134 2020
11
A review of methanol poisoning: a crisis beyond ocular toxicology. 61
32396759 2020
12
[Clinical analysis of 5 cases of occupational acute methanol poisoning]. 61
32536079 2020
13
Secondary visual loss due to inhalation and cutaneous poisoning by methanol and toluene. Presentation of a clinical case. 61
32197876 2020
14
Methanol related death in National Institute of Forensic Medicine, Hospital Kuala Lumpur: A case series. 61
32342937 2020
15
The impact of co-morbidities on a 6-year survival after methanol mass poisoning outbreak: possible role of metabolic formaldehyde. 61
31298045 2020
16
Outcomes After Recurrent Intentional Methanol Exposures Not Treated With Alcohol Dehydrogenase Inhibitors Or Hemodialysis. 61
32307216 2020
17
Metal Oxide (Co3O4 and Mn3O4) Impregnation into S, N-doped Graphene for Oxygen Reduction Reaction (ORR). 61
32231043 2020
18
Methanol outbreak: a Malaysian tertiary hospital experience. 61
32028888 2020
19
Health-related quality of life determinants in survivors of a mass methanol poisoning outbreak: six-year prospective cohort study. 61
31913708 2020
20
Fatal Methanol Poisoning Caused by Drinking Adulterated Locally Distilled Alcohol: Wakiso District, Uganda, June 2017. 61
32405303 2020
21
Consensus statements on the approach to patients in a methanol poisoning outbreak. 61
31328583 2019
22
SPME-GC/MS Analysis of Methanol in Biospecimen by Derivatization with Pyran Compound. 61
31877660 2019
23
Upgrading the Properties of Reduced Graphene Oxide and Nitrogen-Doped Reduced Graphene Oxide Produced by Thermal Reduction toward Efficient ORR Electrocatalysts. 61
31835788 2019
24
Public health response to methanol mass poisoning in the Czech Republic in 2012: a case study. 61
31901190 2019
25
Fe-doped mayenite electride composite with 2D reduced Graphene Oxide: As a non-platinum based, highly durable electrocatalyst for Oxygen Reduction Reaction. 61
31874955 2019
26
Poisoning with Drugs of Abuse: Identification and Management. 61
32021008 2019
27
Antidotes in Poisoning. 61
32020997 2019
28
Transdermal Methanol Intoxication. 61
31823634 2019
29
Methanol outbreak in the district of Hulu Langat, 2018. 61
31649218 2019
30
Uniform copper-cobalt phosphides embedded in N-doped carbon frameworks as efficient bifunctional oxygen electrocatalysts for rechargeable Zn-air batteries. 61
31524914 2019
31
Successful Kidney Transplant From a Brain Stem-Dead Donor Due To Lethal Methanol Poisoning. 61
31615377 2019
32
Single center experience of managing methanol poisoning in the hilly state of Uttarakhand: A cross sectional study. 61
31879603 2019
33
Highly selective detection of methanol over ethanol by a handheld gas sensor. 61
31527675 2019
34
Screening of Workers with Presumed Occupational Methanol Poisoning: The Applicablility of a National Active Occupational Disease Surveillance System. 61
31497324 2019
35
Folate as an Adjuvant Therapy in Methanol Poisoning. 61
31172585 2019
36
Methanol content in homemade alcohol from a province in North Vietnam. 61
31095796 2019
37
Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition. 61
31074872 2019
38
Clinical analysis of severe visual loss caused by inhalational methanol poisoning in a chronic process with acute onset:a retrospective clinical analysis. 61
31174513 2019
39
Clinical and genetic determinants of chronic visual pathway changes after methanol - induced optic neuropathy: four-year follow-up study. 61
30451020 2019
40
Acute kidney injury and the risk of mortality in patients with methanol intoxication. 61
31170938 2019
41
Prediction of Human Pharmacokinetics of Fomepizole from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles. 61
31214899 2019
42
Problems with Methanol Poisoning Outbreaks in Iran. 61
30957140 2019
43
The Methanol Poisoning Outbreaks in Iran 2018. 61
30715164 2019
44
Metal-organic framework-derived metal-free highly graphitized nitrogen-doped porous carbon with a hierarchical porous structure as an efficient and stable electrocatalyst for oxygen reduction reaction. 61
30317082 2019
45
Fe,N-Codoped Graphdiyne Displaying Efficient Oxygen Reduction Reaction Activity. 61
30421574 2019
46
Antidotes Against Methanol Poisoning: A Review. 61
30864518 2019
47
The Hypothesis of Circulus Hypoxicus and Its Clinical Relevance in Patients With Methanol Poisoning - An Observational Study of 35 Patients. 61
29923671 2018
48
Methanol poisoning by solvent inhalation. 61
29859671 2018
49
Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans. 61
29968299 2018
50
[Treatment and nursing care of a patient with severe methanol poisoning]. 61
30646641 2018
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Variations for Methanol Poisoning

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Expression for Methanol Poisoning

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Search GEO for disease gene expression data for Methanol Poisoning.
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Pathways for Methanol Poisoning

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Pathways related to Methanol Poisoning according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Metabolism 65
Show member pathways
 13.73 CYP2E1 ALDH2 ALDH1L1 AKR1A1 ADH5 ADH1C
2
Cytochrome P450 - arranged by substrate type 65
Show member pathways
 12.7 CYP2E1 ALDH2 AKR1A1 ADH5 ADH1C ADH1B
3
Drug metabolism - cytochrome P450 36
Show member pathways
 12.53 CYP2E1 ALDH2 ADH5 ADH1C ADH1B ADH1A
4
Fatty Acyl-CoA Biosynthesis 65
Show member pathways
 12.28 ALDH2 ADH5 ADH1C ADH1B ADH1A
5
Glucose metabolism 65
Show member pathways
 12.01 ALDH2 AKR1A1 ADH5 ADH1C ADH1B ADH1A
6
superpathway of tryptophan utilization 1
Show member pathways
 11.6 ALDH2 AKR1A1 ADH1B
7
Tryptophan metabolism 1 36
Show member pathways
 11.55 CYP2E1 ALDH2
8
Tyrosine metabolism 36
Show member pathways
 11.55 ADH5 ADH1C ADH1B ADH1A
9
Amino Acid metabolism 1
11.53 ADH5 ADH1C
10
Signaling by Retinoic Acid 65
Show member pathways
 11.39 ADH1C ADH1A
11
Glycerolipid metabolism 36
11.34 ALDH2 AKR1A1
12
Vitamin A and Carotenoid Metabolism 1
11.19 CYP2E1 ADH1A
13
Naphthalene metabolism 22
10.92 CYP2E1 AKR1A1
14
ethanol degradation II 1
Show member pathways
 10.81 CYP2E1 ALDH2 ADH1B
15
noradrenaline and adrenaline degradation 1
Show member pathways
 10.73 ALDH2 ADH1B
16
Abacavir Pathway, Pharmacokinetics/Pharmacodynamics 60
10.69 ADH1C ADH1B ADH1A
17
Cyclophosphamide Pathway, Pharmacodynamics 60
Show member pathways
 10.59 ALDH2 AKR1A1 ADH5 ADH1C ADH1B ADH1A
18
acetone degradation I (to methylglyoxal) 1
Show member pathways
 10.55 CYP2E1 ADH1B
19
Folate-Alcohol and Cancer Pathway 1
10.34 CYP2E1 ALDH1L1 ADH5
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GO Terms for Methanol Poisoning

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Biological processes related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 CYP2E1 ALDH2 ALDH1L1 AKR1A1 ADH5 ADH1C
2 electron transport chain GO:0022900 9.54 ALDH2 AKR1A1 ADH5
3 retinoid metabolic process GO:0001523 9.43 ADH5 ADH1B
4 retinol metabolic process GO:0042572 9.43 ADH1C ADH1B ADH1A
5 drug metabolic process GO:0017144 9.4 CYP2E1 ADH1A
6 retinoic acid metabolic process GO:0042573 9.33 ADH1C ADH1B ADH1A
7 alcohol metabolic process GO:0006066 9.32 ALDH2 ADH1A
8 ethanol oxidation GO:0006069 9.02 ALDH2 ADH5 ADH1C ADH1B ADH1A

Molecular functions related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.73 ADH5 ADH1C ADH1B ADH1A
2 electron transfer activity GO:0009055 9.5 ALDH2 AKR1A1 ADH5
3 retinol dehydrogenase activity GO:0004745 9.46 AKR1A1 ADH1C ADH1B ADH1A
4 alcohol dehydrogenase (NAD) activity GO:0004022 9.43 ADH5 ADH1C ADH1A
5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 9.4 ALDH2 ALDH1L1
6 aldehyde dehydrogenase (NAD) activity GO:0004029 9.37 ALDH2 ALDH1L1
7 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.26 ADH5 ADH1C ADH1B ADH1A
8 oxidoreductase activity GO:0016491 9.23 CYP2E1 ALDH2 ALDH1L1 AKR1A1 ADH5 ADH1C
Sources

Sources for Methanol Poisoning

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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