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MCID: MTH047
MIFTS: 37

Methanol Poisoning

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Methanol Poisoning

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MalaCards integrated aliases for Methanol Poisoning:

Name: Methanol Poisoning 58

Characteristics:

Orphanet epidemiological data:

58
methanol poisoning
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Methanol Poisoning

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MalaCards based summary : Methanol Poisoning is related to alcohol use disorder and alcoholic liver cirrhosis. An important gene associated with Methanol Poisoning is AKR1A1 (Aldo-Keto Reductase Family 1 Member A1), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Fomepizole and Antidotes have been mentioned in the context of this disorder. Affiliated tissues include liver, globus pallidus and cortex, and related phenotypes are metabolic acidosis and hypertension

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Related Diseases for Methanol Poisoning

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Diseases related to Methanol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 alcohol use disorder 29.1 CYP2E1 ALDH2 AKR1A1 ADH1C ADH1B
2 alcoholic liver cirrhosis 28.5 CYP2E1 ALDH2 AKR1A1 ADH1C ADH1B
3 liver cirrhosis 28.5 CYP2E1 ALDH2 AKR1A1 ADH1C ADH1B
4 alcohol dependence 27.9 CYP2E1 ALDH2 AKR1A1 ADH5 ADH1C ADH1B
5 metabolic acidosis 10.8
6 yemenite deaf-blind hypopigmentation syndrome 10.6
7 ocular motor apraxia 10.6
8 optic nerve disease 10.4
9 3-methylglutaconic aciduria, type iii 10.4
10 neuropathy 10.3
11 parkinsonism 10.2
12 toxic optic neuropathy 10.2
13 tremor 10.2
14 ethylene glycol poisoning 10.2
15 hyperglycemia 10.1
16 hypoglycemia 10.1
17 ataxia and polyneuropathy, adult-onset 10.1
18 covid-19 10.1
19 polyneuropathy 10.1
20 acute pancreatitis 10.1
21 lactic acidosis 10.1
22 hypocalciuric hypercalcemia, familial, type i 10.0 ADH1B ADH1A
23 familial hypocalciuric hypercalcemia 10.0 ADH1B ADH1A
24 aspartylglucosaminuria 9.9 ADH1C ADH1B
25 hypocalcemia, autosomal dominant 1 9.9 ADH1B ADH1A
26 focal dermal hypoplasia 9.9 ALDH1L1 ADH5
27 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
28 pulmonary disease, chronic obstructive 9.9
29 proteinuria, chronic benign 9.9
30 aspiration pneumonia 9.9
31 oromandibular dystonia 9.9
32 myoglobinuria 9.9
33 non-alcoholic fatty liver disease 9.9
34 partial optic atrophy 9.9
35 amnestic disorder 9.9
36 respiratory failure 9.9
37 optic neuritis 9.9
38 renal tubular acidosis 9.9
39 papilledema 9.9
40 neuritis 9.9
41 ischemia 9.9
42 thrombophlebitis 9.9
43 retrograde amnesia 9.9
44 dystonia 9.9
45 peripheral nervous system disease 9.9
46 subacute delirium 9.9
47 scotoma 9.9
48 pathologic nystagmus 9.9
49 anton's syndrome 9.9
50 cytokine deficiency 9.9

Graphical network of the top 20 diseases related to Methanol Poisoning:



Diseases related to Methanol Poisoning
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Symptoms & Phenotypes for Methanol Poisoning

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Human phenotypes related to Methanol Poisoning:

58 31 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 metabolic acidosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001942
2 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
3 hyperlipidemia 58 31 frequent (33%) Frequent (79-30%) HP:0003077
4 blurred vision 58 31 frequent (33%) Frequent (79-30%) HP:0000622
5 abnormal putamen morphology 58 31 frequent (33%) Frequent (79-30%) HP:0031982
6 alcoholism 58 31 frequent (33%) Frequent (79-30%) HP:0030955
7 type ii diabetes mellitus 58 31 occasional (7.5%) Occasional (29-5%) HP:0005978
8 blindness 58 31 occasional (7.5%) Occasional (29-5%) HP:0000618
9 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
10 myocardial infarction 58 31 occasional (7.5%) Occasional (29-5%) HP:0001658
11 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
12 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
13 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
14 confusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0001289
15 abnormality of the optic nerve 58 31 occasional (7.5%) Occasional (29-5%) HP:0000587
16 abnormal corpus callosum morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0001273
17 bilateral basal ganglia lesions 58 31 occasional (7.5%) Occasional (29-5%) HP:0007146
18 abnormal globus pallidus morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002453
19 basal ganglia necrosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012128
20 type i diabetes mellitus 58 31 very rare (1%) Very rare (<4-1%) HP:0100651
21 cerebral hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0001342
22 abnormal caudate nucleus morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0002339
23 abnormal morphology of the cerebellar cortex 58 31 very rare (1%) Very rare (<4-1%) HP:0031422
24 permanent atrial fibrillation 58 31 very rare (1%) Very rare (<4-1%) HP:0004754
25 inflammatory arteriopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0005291
26 seizure 31 very rare (1%) HP:0001250
27 seizures 58 Very rare (<4-1%)
28 visual impairment 58 Frequent (79-30%)
29 intracranial hemorrhage 58 Frequent (79-30%)
30 abnormality of the cerebral white matter 58 Occasional (29-5%)
Sources

Drugs & Therapeutics for Methanol Poisoning

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Drugs for Methanol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fomepizole Approved, Vet_approved 7554-65-6 3406
2 Antidotes
3 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Specified Drug-use Survey of Fomepizole Intravenous Infusion "Takeda" (All-case Surveillance) Recruiting NCT02415712 Fomepizole
2 Red Cell Distribution Width as a Predictor of Mortality in Acute Methanol Poisoning Not yet recruiting NCT04064801

Search NIH Clinical Center for Methanol Poisoning

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Genetic Tests for Methanol Poisoning

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Anatomical Context for Methanol Poisoning

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MalaCards organs/tissues related to Methanol Poisoning:

40
Liver, Globus Pallidus, Cortex, Caudate Nucleus, Retina, Whole Blood, Breast
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Publications for Methanol Poisoning

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Articles related to Methanol Poisoning:

(show top 50) (show all 587)
# Title Authors PMID Year
1
Death by hand sanitizer: syndemic methanol poisoning in the age of COVID-19. 61
33755514 2021
2
COVID-19 and Alcohol Poisoning: A Fatal Competition. 61
33762062 2021
3
Efficiency of 123I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study. 61
32762574 2021
4
Bimetallic Hollow Tubular NiCoOx as a Bifunctional Electrocatalyst for Enhanced Oxygen Reduction and Evolution Reaction. 61
33538592 2021
5
Screening Methanol Poisoning with a Portable Breath Detector. 61
33315383 2021
6
Successful Kidney Transplant From a Brain Stem-Dead Donor Due To Lethal Methanol Poisoning. 61
31615377 2020
7
Investigating the epidemiology of the methanol poisoning outbreaks in the third millennium: a scoping review protocol. 61
33323771 2020
8
Alcohol intake in an attempt to fight COVID-19: A medical myth in Iran. 61
32693023 2020
9
Methanol poisoning in Turkey: Two outbreaks, a single center experience. 61
32702502 2020
10
Epidemiological profile of methanol poisoning, El Hajeb, Morocco. 61
33226112 2020
11
The outbreak of methanol intoxication during COVID-19 pandemic: prevalence of brain lesions and its predisposing factors. 61
33172326 2020
12
Atypical presentation of COVID-19; an observational retrospective study. 61
33225911 2020
13
[Treatment outcome analysis of 23 cases of occupational inhalation severe methanol poisoning]. 61
33142382 2020
14
A syndemic of COVID-19 and methanol poisoning in Iran: Time for Iran to consider alcohol use as a public health challenge? 61
32505493 2020
15
A review of methanol poisoning: a crisis beyond ocular toxicology. 61
32396759 2020
16
MRI-based brain volumetry and retinal optical coherence tomography as the biomarkers of outcome in acute methanol poisoning. 61
32554081 2020
17
Health-related quality of life determinants in survivors of a mass methanol poisoning outbreak: six-year prospective cohort study. 61
31913708 2020
18
Electrocardiographic findings of methanol toxicity: a cross-sectional study of 356 cases in Iran. 61
32928149 2020
19
Chronic methanol toxicity through topical and inhalational routes presenting as vision loss and restricted diffusion of the optic nerves on MRI: A case report and literature review. 61
32775706 2020
20
Lessons from a methanol poisoning outbreak in Egypt: Six case reports. 61
32844091 2020
21
Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol - Arizona and New Mexico, May-June 2020. 61
32790662 2020
22
A Surge in Methanol Poisoning Amid COVID-19 Pandemic: Why Is This Occurring? 61
32536420 2020
23
Analysis of fomepizole safety based on a 16-year post-marketing experience in France. 61
31608703 2020
24
[Two cases of acute inhalation methanol poisoning]. 61
32746583 2020
25
Peripheral polyneuropathy after acute methanol poisoning: Six-year prospective cohort study. 61
32380190 2020
26
Dilemma in the management of methanol poisoning at a district hospital in Malaysia. 61
32724013 2020
27
Outcomes After Recurrent Intentional Methanol Exposures Not Treated With Alcohol Dehydrogenase Inhibitors Or Hemodialysis. 61
32307216 2020
28
Toll of acute methanol poisoning for preventing COVID-19. 61
32462212 2020
29
Status of clinical toxicology education and ethics in medical care of poisoned patients in the Islamic Republic of Iran and a comparison with other countries. 61
31863569 2020
30
Methanol induced stroke: report of cases occurring simultaneously in two biological brothers. 61
32864054 2020
31
New Methanol Poisoning Outbreaks in Iran Following COVID-19 Pandemic. 61
32400874 2020
32
Comment on consensus statements on the approach to patients in a methanol poisoning outbreak. 61
31496310 2020
33
[Clinical analysis of 5 cases of occupational acute methanol poisoning]. 61
32536079 2020
34
Secondary visual loss due to inhalation and cutaneous poisoning by methanol and toluene. Presentation of a clinical case. 61
32197876 2020
35
Methanol Poisoning Emerging as the Result of COVID-19 Outbreak; Radiologic Perspective. 61
32273134 2020
36
Methanol related death in National Institute of Forensic Medicine, Hospital Kuala Lumpur: A case series. 61
32342937 2020
37
The impact of co-morbidities on a 6-year survival after methanol mass poisoning outbreak: possible role of metabolic formaldehyde. 61
31298045 2020
38
Metal Oxide (Co3O4 and Mn3O4) Impregnation into S, N-doped Graphene for Oxygen Reduction Reaction (ORR). 61
32231043 2020
39
Methanol outbreak: a Malaysian tertiary hospital experience. 61
32028888 2020
40
Prognostic Factors of Outcome in Methanol Poisoning; an 8-year Retrospective Cross-sectional Study. 61
33134965 2020
41
Late Functional and Morphological Findings after Methylalcohol Poisoning. 61
33691428 2020
42
Fatal Methanol Poisoning Caused by Drinking Adulterated Locally Distilled Alcohol: Wakiso District, Uganda, June 2017. 61
32405303 2020
43
[Structural and functional changes in the retina and optic nerve in patients with toxic optic neuropathy caused by acute methanol poisoning]. 61
32880146 2020
44
Poisoning with Drugs of Abuse: Identification and Management. 61
32021008 2019
45
Upgrading the Properties of Reduced Graphene Oxide and Nitrogen-Doped Reduced Graphene Oxide Produced by Thermal Reduction toward Efficient ORR Electrocatalysts. 61
31835788 2019
46
SPME-GC/MS Analysis of Methanol in Biospecimen by Derivatization with Pyran Compound. 61
31877660 2019
47
Consensus statements on the approach to patients in a methanol poisoning outbreak. 61
31328583 2019
48
Fe-doped mayenite electride composite with 2D reduced Graphene Oxide: As a non-platinum based, highly durable electrocatalyst for Oxygen Reduction Reaction. 61
31874955 2019
49
Public health response to methanol mass poisoning in the Czech Republic in 2012: a case study. 61
31901190 2019
50
Antidotes in Poisoning. 61
32020997 2019
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Variations for Methanol Poisoning

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Expression for Methanol Poisoning

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Search GEO for disease gene expression data for Methanol Poisoning.
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Pathways for Methanol Poisoning

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Pathways related to Methanol Poisoning according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Metabolism 65
Show member pathways
 13.73 CYP2E1 ALDH2 ALDH1L1 AKR1A1 ADH5 ADH1C
2
Cytochrome P450 - arranged by substrate type 65
Show member pathways
 12.71 CYP2E1 ALDH2 AKR1A1 ADH5 ADH1C ADH1B
3
Drug metabolism - cytochrome P450 36
Show member pathways
 12.53 CYP2E1 ALDH2 ADH5 ADH1C ADH1B ADH1A
4
Fatty Acyl-CoA Biosynthesis 65
Show member pathways
 12.25 ALDH2 ADH5 ADH1C ADH1B ADH1A
5
Glucose metabolism 65
Show member pathways
 12.07 ALDH2 AKR1A1 ADH5 ADH1C ADH1B ADH1A
6
superpathway of tryptophan utilization 1
Show member pathways
 11.6 ALDH2 AKR1A1 ADH1B
7
Phenylalanine metabolism 36
Show member pathways
 11.57 ADH5 ADH1C ADH1B ADH1A
8
Tryptophan metabolism 1 36
Show member pathways
 11.56 CYP2E1 ALDH2
9
Amino Acid metabolism 1
11.54 ADH5 ADH1C
10
Pentose and glucuronate interconversions 36
Show member pathways
 11.43 ALDH2 AKR1A1
11
Signaling by Retinoic Acid 65
Show member pathways
 11.39 ADH1C ADH1A
12
Glycerolipid metabolism 36
11.34 ALDH2 AKR1A1
13
Vitamin A and Carotenoid Metabolism 1
11.19 CYP2E1 ADH1A
14
Naphthalene metabolism 23
10.92 CYP2E1 AKR1A1
15
ethanol degradation II 1
Show member pathways
 10.81 CYP2E1 ALDH2 ADH1B
16
Abacavir Pathway, Pharmacokinetics/Pharmacodynamics 60
Show member pathways
 10.76 ADH1C ADH1B ADH1A
17
noradrenaline and adrenaline degradation 1
Show member pathways
 10.7 ALDH2 ADH1B
18
Cyclophosphamide Pathway, Pharmacodynamics 60
Show member pathways
 10.59 ALDH2 AKR1A1 ADH5 ADH1C ADH1B ADH1A
19
acetone degradation I (to methylglyoxal) 1
Show member pathways
 10.55 CYP2E1 ADH1B
20
Folate-Alcohol and Cancer Pathway 1
10.34 CYP2E1 ALDH1L1 ADH5
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GO Terms for Methanol Poisoning

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Biological processes related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 CYP2E1 ALDH2 ALDH1L1 AKR1A1 ADH5 ADH1C
2 electron transport chain GO:0022900 9.54 ALDH2 AKR1A1 ADH5
3 retinoid metabolic process GO:0001523 9.43 ADH5 ADH1B
4 retinol metabolic process GO:0042572 9.43 ADH1C ADH1B ADH1A
5 drug metabolic process GO:0017144 9.4 CYP2E1 ADH1A
6 retinoic acid metabolic process GO:0042573 9.33 ADH1C ADH1B ADH1A
7 alcohol metabolic process GO:0006066 9.32 ALDH2 ADH1A
8 ethanol oxidation GO:0006069 9.02 ALDH2 ADH5 ADH1C ADH1B ADH1A

Molecular functions related to Methanol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.73 ADH5 ADH1C ADH1B ADH1A
2 electron transfer activity GO:0009055 9.5 ALDH2 AKR1A1 ADH5
3 retinol dehydrogenase activity GO:0004745 9.46 AKR1A1 ADH1C ADH1B ADH1A
4 alcohol dehydrogenase (NAD) activity GO:0004022 9.43 ADH5 ADH1C ADH1A
5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 9.4 ALDH2 ALDH1L1
6 aldehyde dehydrogenase (NAD) activity GO:0004029 9.37 ALDH2 ALDH1L1
7 alcohol dehydrogenase activity, zinc-dependent GO:0004024 9.26 ADH5 ADH1C ADH1B ADH1A
8 oxidoreductase activity GO:0016491 9.23 CYP2E1 ALDH2 ALDH1L1 AKR1A1 ADH5 ADH1C
Sources

Sources for Methanol Poisoning

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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