MCID: MTH007
MIFTS: 48

Methemoglobinemia

Categories: Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Methemoglobinemia

MalaCards integrated aliases for Methemoglobinemia:

Name: Methemoglobinemia 12 76 37 55 6 44 15 40 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10783
ICD10 33 D74 D74.9
ICD9CM 35 289.7
MeSH 44 D008708
NCIt 50 C34817
SNOMED-CT 68 38959009
KEGG 37 H00235
UMLS 73 C0025637

Summaries for Methemoglobinemia

MalaCards based summary : Methemoglobinemia is related to hereditary methemoglobinemia and acquired methemoglobinemia, and has symptoms including cyanosis An important gene associated with Methemoglobinemia is CYB5R3 (Cytochrome B5 Reductase 3), and among its related pathways/superpathways are Amino sugar and nucleotide sugar metabolism and Metabolism. The drugs Lidocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and skin.

Wikipedia : 76 Methemoglobinemia is a condition caused by elevated levels of methemoglobin in the blood. Methemoglobin... more...

Related Diseases for Methemoglobinemia

Diseases in the Methemoglobinemia family:

Methemoglobinemia, Beta Type Methemoglobinemia, Alpha Type
Congenital Methemoglobinemia Hereditary Methemoglobinemia
Acquired Methemoglobinemia

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 hereditary methemoglobinemia 34.0 HBG2 CYB5R3 CYB5A
2 acquired methemoglobinemia 33.5 HBG2 G6PD CYB5R3
3 congenital methemoglobinemia 33.2 HBG2 G6PD CYB5R3 CYB5A
4 hemolytic anemia 30.3 HP HBG2 HBB G6PD
5 glucosephosphate dehydrogenase deficiency 29.8 HP HBG2 HBB G6PD
6 beta-thalassemia 29.7 HBG2 HBB G6PD
7 hemoglobinopathy 29.4 HP HBB
8 methemoglobinemia due to deficiency of methemoglobin reductase 12.7
9 methemoglobinemia and ambiguous genitalia 12.5
10 methemoglobinemia, beta-globin type 12.5
11 methemoglobinemia, alpha type 12.3
12 methemoglobinemia, beta type 12.3
13 methemoglobin reductase deficiency 10.2
14 sulfhemoglobinemia 10.2
15 diarrhea 10.2
16 pneumonia 10.2
17 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 10.1 HBG2 HBB
18 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 10.1 HBG2 HBB
19 fetal hemoglobin quantitative trait locus 1 10.1 HBG2 HBB
20 malaria 10.1
21 respiratory failure 10.1
22 blood protein disease 10.1 HBG2 HBB
23 burns 10.0
24 leukemia 10.0
25 thalassemia 10.0
26 isoniazid toxicity 10.0 NAT2 CYP2E1
27 sickle cell disease 10.0 HBG2 HBB G6PD
28 hemoglobin h disease 10.0 HBG2 HBB G6PD
29 hemoglobinemia 10.0 HP HBB
30 sickle cell anemia 10.0 HBG2 HBB G6PD
31 drug-induced hepatitis 10.0 NAT2 CYP2E1
32 acetaminophen metabolism 10.0 CYP3A4 CYP2E1
33 heinz body anemias 9.9
34 alkaptonuria 9.9
35 enterocolitis 9.9
36 asthma 9.9
37 lymphoma 9.9
38 pneumocystosis 9.9
39 heart disease 9.9
40 acute cystitis 9.9
41 ochronosis 9.9
42 lupus erythematosus 9.9
43 molluscum contagiosum 9.9
44 hypoxia 9.9
45 syncope 9.9
46 blackwater fever 9.9 HP G6PD
47 anemia, nonspherocytic hemolytic, due to g6pd deficiency 9.9 HP G6PD
48 iron overload in africa 9.9 HP HBB
49 bilirubin metabolic disorder 9.8 HP G6PD
50 congenital hemolytic anemia 9.8 HP HBB G6PD

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to Methemoglobinemia

Symptoms & Phenotypes for Methemoglobinemia

UMLS symptoms related to Methemoglobinemia:


cyanosis

Drugs & Therapeutics for Methemoglobinemia

Drugs for Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
4
Prilocaine Approved Phase 4,Phase 2,Not Applicable 721-50-6 4906
5
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
7
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
8
Methylene blue Approved, Investigational Phase 4,Phase 1,Early Phase 1 61-73-4
9 Diuretics, Potassium Sparing Phase 4,Not Applicable
10 Anesthetics, Local Phase 4,Phase 2,Not Applicable
11 Anti-Arrhythmia Agents Phase 4,Not Applicable
12 Hypnotics and Sedatives Phase 4
13 Anesthetics, Intravenous Phase 4
14 Anesthetics Phase 4,Phase 2,Not Applicable
15 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
16 Sodium Channel Blockers Phase 4,Not Applicable
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Anesthetics, General Phase 4
19 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
20 diuretics Phase 4
21 Natriuretic Agents Phase 4
22 Epinephryl borate Phase 4,Not Applicable
23
Primaquine Approved Phase 3,Phase 1,Not Applicable 90-34-6 4908
24
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
25 tannic acid Approved Phase 3
26
Glycerol Approved, Investigational Phase 3 56-81-5 753
27 Tafenoquine Approved, Investigational Phase 3 106635-80-7
28
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
29
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
30 Antimalarials Phase 3,Phase 1,Not Applicable
31 Antiparasitic Agents Phase 3,Phase 1,Not Applicable
32 Anti-Infective Agents Phase 3,Phase 1,Not Applicable
33 Antiprotozoal Agents Phase 3,Phase 1,Not Applicable
34 Protective Agents Phase 3
35 Anti-Asthmatic Agents Phase 3,Not Applicable
36 Respiratory System Agents Phase 3,Not Applicable
37 Bronchodilator Agents Phase 3,Not Applicable
38 Neurotransmitter Agents Phase 3,Not Applicable
39 Autonomic Agents Phase 3,Not Applicable
40 Artemisinins Phase 3,Not Applicable
41 Artemisinine Phase 3,Not Applicable
42 Vasodilator Agents Phase 3
43 Endothelium-Dependent Relaxing Factors Phase 3
44 Antioxidants Phase 3
45 Free Radical Scavengers Phase 3
46
Morphine Approved, Investigational Phase 2 57-27-2 5288826
47 Narcotics Phase 2
48 Analgesics Phase 2
49 Analgesics, Opioid Phase 2
50
leucovorin Approved Phase 1 58-05-9 6006 143

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol Completed NCT01489891 Phase 4 Lidocaine;Placebo
2 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4 Pyridium;Sodium Fluorescein;Mannitol
3 MEthylene Blue In Patients With Acquired Methemoglobinemia Recruiting NCT03395223 Phase 4 Methylene Blue
4 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Completed NCT02044341 Phase 3 AR01;Glycerin ear drops
5 Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis Recruiting NCT03053388 Phase 3 Nitric Oxide
6 Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria Recruiting NCT02802501 Phase 3 Tafenoquine;Matched-Placebo for Tafenoquine;Primaquine;Matched-Placebo for Primaquine;Dihydroartemisinin-piperaquine (DHA-PQP);ACT plus PQ (Rescue medication);PQ (End of study treatment)
7 Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Terminated NCT00005776 Phase 3 Inhaled nitric oxide;Placebo
8 Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Terminated NCT00005773 Phase 3 Inhaled Nitric Oxide;Standard iNO therapy
9 Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery Unknown status NCT01098409 Phase 2 sodium nitrite;0.9% sodium chloride
10 Estimation of the Effective Dose (ED) 95 of Intrathecal Hyperbaric Prilocaine 2% for Scheduled Cesarean Delivery. Completed NCT03607916 Phase 2 Hyperbaric prilocaine 2%;Hyperbaric prilocaine 2%;Morphine
11 Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction Completed NCT01584453 Phase 2 Sodium Nitrite;Sodium Chloride Placebo
12 Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers Recruiting NCT02863068 Phase 2 Topical Sodium Nitrite
13 Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration Completed NCT02493283 Phase 1 Dapsone single dose;Dapsone multiple dose
14 Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults Completed NCT02478281 Phase 1 Methylene Blue
15 Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects Completed NCT00000740 Phase 1 Sitamaquine
16 Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency Completed NCT01668433 Phase 1 Regimens (Primaquine, Methylene blue)
17 Nitrite Infusion in Healthy Volunteers Completed NCT00103025 Phase 1 Sodium Nitrite;Sodium Nitrite Injection
18 First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor Completed NCT02661373 Phase 1 SJ733;Cobicistat
19 Safety and Efficacy of Primaquine for P. Vivax Unknown status NCT01837992 Not Applicable Primaquine;delayed primaquine
20 Methemoglobinemia After Liposuction - Diagnostic by Pulse Oximetry and Blood Gas Analysis. Completed NCT01766999
21 Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone Completed NCT00993694 chemotherapy;dapsone
22 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics Completed NCT01402869 Not Applicable 4% prilocaine plain;2% Lidocaine with 1:100,000 epinephrine
23 Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients Completed NCT01883713
24 Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria Completed NCT02528279 Not Applicable Coartem
25 Lidocaine Spray on an Endoscope to Improve Tolerance to Endoscopy Completed NCT02307773 Case Group
26 Acquired Methemoglobinemia Observational Registry Recruiting NCT03542760 Methylene Blue
27 MOM's PAIN (Methylene Blue for Oral Mucositis' PAIN) Not yet recruiting NCT03469284 Early Phase 1 Methylene Blue (MB) 0.025%;Methylene Blue (MB) 0.05%;Methylene Blue (MB) 0.1%

Search NIH Clinical Center for Methemoglobinemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: methemoglobinemia

Genetic Tests for Methemoglobinemia

Anatomical Context for Methemoglobinemia

MalaCards organs/tissues related to Methemoglobinemia:

41
Lung, Kidney, Skin, Testes, Heart, Whole Blood, Liver

Publications for Methemoglobinemia

Articles related to Methemoglobinemia:

(show top 50) (show all 1039)
# Title Authors Year
1
Fatal methemoglobinemia complicating alkaptonuria (ochronosis): a rare presentation. ( 29572623 )
2018
2
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. ( 29627919 )
2018
3
Role of Automated Therapeutic Red Cell Exchange in the Setting of Acute Methemoglobinemia: Our Experience. ( 29398814 )
2018
4
Methemoglobinemia in an HIV patient. ( 29522394 )
2018
5
A new mutation of congenital methemoglobinemia exacerbated after methylene blue treatment. ( 29657736 )
2018
6
Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I. ( 29482478 )
2018
7
Benzocaine-Associated Methemoglobinemia. ( 29912717 )
2018
8
Dapsone-induced Methemoglobinemia in a Child with End-stage Renal Disease: A Brief Review. ( 29930890 )
2018
9
Methemoglobinemia: A Girl with 'Chocolate Brown' Colored Blood. ( 29777467 )
2018
10
Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options. ( 29519718 )
2018
11
Severe Heinz body anemia and methemoglobinemia in a kitten with chronic diarrhea. ( 29615382 )
2018
12
Methemoglobinemia in a Case of Paint Thinner Intoxication, Treated Successfully with Vitamin C. ( 29258784 )
2018
13
Methemoglobinemia should be suspected when oxygen saturation apparently decreases after prilocaine infiltration during intravenous sedation. ( 29881568 )
2018
14
Severe decrease in SpO<sub>2</sub> and methemoglobinemia following subareolar isosulfan blue administration and clinical relevance. ( 29756115 )
2018
15
Congenital methemoglobinemia misdiagnosed as polycythemia vera: Case report and review of literature. ( 29721250 )
2018
16
Congenital methemoglobinemia type II in a 5-year-old boy. ( 29375859 )
2018
17
Food Protein-Induced Enterocolitis Syndrome Causing Hypovolemic Shock and Methemoglobinemia. ( 29854475 )
2018
18
The first case of methemoglobinemia associated with omalizumab. ( 29339124 )
2018
19
Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene. ( 29356095 )
2018
20
The Acute Treatment of Methemoglobinemia in Pregnancy. ( 29627348 )
2018
21
Letter in response to "Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury". ( 29164951 )
2018
22
On the dysfunctional hemoglobins and cyanosis connection: practical implications for the clinical detection and differentiation of methemoglobinemia and sulfhemoglobinemia. ( 29984098 )
2018
23
Methemoglobinemia Induced By Ingesting Lava Lamp Contents. ( 30083634 )
2018
24
Poppers-Induced Life-Threatening Methemoglobinemia. ( 30113866 )
2018
25
Ochronosis Presenting as Methemoglobinemia. ( 30229904 )
2018
26
Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats. ( 30269455 )
2018
27
Methemoglobinemia during the Use of Glyceryl Trinitrate Patches in Neonates: Two Case Reports. ( 30345159 )
2018
28
Naphthalene Toxicity: Methemoglobinemia and Acute Intravascular Hemolysis. ( 30345203 )
2018
29
Methemoglobinemia treated with hyperbaric oxygen therapy: A case report. ( 30533564 )
2018
30
Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia. ( 28370399 )
2017
31
A Case of Cyanosis: Dapsone Induced Methemoglobinemia and Coexisting Pulmonary Embolism. ( 28418946 )
2017
32
Acquired Methemoglobinemia - A Sporadic Holi Disaster. ( 28667718 )
2017
33
Upward trend of dapsone-induced methemoglobinemia in renal transplant communitya8c. ( 28699887 )
2017
34
Transient Methemoglobinemia in three Neonates due to Maternal Pudendal Anesthesia. ( 29185409 )
2017
35
Benzocaine-Induced Methemoglobinemia. ( 29102098 )
2017
36
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency. ( 28963729 )
2017
37
Cotrimoxazole-induced Methemoglobinemia. ( 28984267 )
2017
38
An Unusual Case of Neonatal Methemoglobinemia. ( 28285300 )
2017
39
A puzzling case of methemoglobinemia. ( 28370418 )
2017
40
Laundry Blues: a case of methemoglobinemia with laundry detergent and Tylenol ingestion. ( 28911028 )
2017
41
Rasburicase-induced methemoglobinemia: The eyes do not see what the mind does not know. ( 28345492 )
2017
42
Methemoglobinemia Due to Antifreeze Ingestion. ( 29141168 )
2017
43
Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( 28875384 )
2017
44
Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia). ( 27879543 )
2017
45
Methylene Blue Induced Methemoglobinemia with Acute Kidney Injury in a Glucose-6-Phosphate Dehydrogenase-deficient Patient. ( 29217886 )
2017
46
Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury. ( 28969436 )
2017
47
A Case of Methemoglobinemia Successfully Treated with Hyperbaric Oxygenation Monotherapy. ( 28838565 )
2017
48
Plasmapheresis in severe methemoglobinemia following occupational exposure. ( 28259531 )
2017
49
Primaquine in Plasma and Methemoglobinemia in Patients with Malaria Due to Plasmodium vivax in the Brazilian Amazon Basin. ( 28440745 )
2017
50
Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl. ( 28765205 )
2017

Variations for Methemoglobinemia

ClinVar genetic disease variations for Methemoglobinemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 subset of 22 genes:FLCN; RAI1 GRCh37/hg19 17p11.2(chr17: 16936603-18184130) copy number loss Pathogenic GRCh37 Chromosome 17, 16936603: 18184130

Expression for Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for Methemoglobinemia

Pathways related to Methemoglobinemia according to KEGG:

37
# Name Kegg Source Accession
1 Amino sugar and nucleotide sugar metabolism hsa00520

Pathways related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 CYB5A CYB5R2 CYB5R3 CYP2E1 CYP3A4 G6PD
2
Show member pathways
12.64 CYB5A CYB5R2 CYB5R3 CYP2E1 CYP3A4 NAT2
3 12.14 CYP3A4 G6PD HBB
4
Show member pathways
11.38 CYP2E1 CYP3A4
5
Show member pathways
11.33 CYP2E1 CYP3A4
6
Show member pathways
11.3 CYP2E1 CYP3A4
7
Show member pathways
11.05 CYP2E1 CYP3A4
8
Show member pathways
10.98 CYB5R2 HBB
9 10.95 CYP2E1 CYP3A4
10 10.75 CYP2E1 CYP3A4
11 10.62 CYP2E1 CYP3A4
12
Show member pathways
10.56 CYP2E1 CYP3A4 NAT2
13 9.4 CYB5A CYB5R3 G6PD

GO Terms for Methemoglobinemia

Cellular components related to Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.71 CYB5A CYP2E1 CYP3A4 G6PD
2 endoplasmic reticulum membrane GO:0005789 9.65 CYB5A CYB5R2 CYB5R3 CYP2E1 CYP3A4
3 blood microparticle GO:0072562 9.54 HBB HBG2 HP
4 tertiary granule lumen GO:1904724 9.43 HBB HP
5 organelle membrane GO:0031090 9.33 CYB5A CYP2E1 CYP3A4
6 endocytic vesicle lumen GO:0071682 9.32 HBB HP
7 hemoglobin complex GO:0005833 9.13 CYB5R3 HBB HBG2
8 haptoglobin-hemoglobin complex GO:0031838 8.8 HBB HBG2 HP

Biological processes related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.78 CYB5R2 CYB5R3 CYP3A4 G6PD
2 steroid biosynthetic process GO:0006694 9.58 CYB5R2 CYB5R3
3 response to hydrogen peroxide GO:0042542 9.58 HBB HP
4 positive regulation of cell death GO:0010942 9.57 HBB HP
5 bicarbonate transport GO:0015701 9.56 CYB5R2 HBB
6 cholesterol biosynthetic process GO:0006695 9.55 CYB5R3 G6PD
7 sterol biosynthetic process GO:0016126 9.54 CYB5R2 CYB5R3
8 xenobiotic metabolic process GO:0006805 9.54 CYP2E1 CYP3A4 NAT2
9 hydrogen peroxide catabolic process GO:0042744 9.52 HBB HBG2
10 drug metabolic process GO:0017144 9.51 CYP2E1 CYP3A4
11 cellular oxidant detoxification GO:0098869 9.5 HBB HBG2 HP
12 exogenous drug catabolic process GO:0042738 9.49 CYP2E1 CYP3A4
13 long-chain fatty acid biosynthetic process GO:0042759 9.46 CYP2E1 CYP3A4
14 oxygen transport GO:0015671 9.43 HBB HBG2
15 oxidation-reduction process GO:0055114 9.43 CYB5A CYB5R2 CYB5R3 CYP2E1 CYP3A4 G6PD
16 L-ascorbic acid metabolic process GO:0019852 9.4 CYB5A CYB5R3
17 heterocycle metabolic process GO:0046483 9.26 CYP2E1 CYP3A4
18 monoterpenoid metabolic process GO:0016098 9.16 CYP2E1 CYP3A4
19 steroid metabolic process GO:0008202 8.92 CYB5R2 CYB5R3 CYP2E1 CYP3A4

Molecular functions related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 CYB5A CYP2E1 CYP3A4
2 oxidoreductase activity GO:0016491 9.55 CYB5R2 CYB5R3 CYP2E1 CYP3A4 G6PD
3 monooxygenase activity GO:0004497 9.52 CYP2E1 CYP3A4
4 FAD binding GO:0071949 9.51 CYB5R2 CYB5R3
5 peroxidase activity GO:0004601 9.49 HBB HBG2
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.48 CYP2E1 CYP3A4
7 steroid hydroxylase activity GO:0008395 9.46 CYP2E1 CYP3A4
8 oxygen carrier activity GO:0005344 9.43 HBB HBG2
9 organic acid binding GO:0043177 9.4 HBB HBG2
10 haptoglobin binding GO:0031720 9.37 HBB HBG2
11 heme binding GO:0020037 9.35 CYB5A CYP2E1 CYP3A4 HBB HBG2
12 cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 9.32 CYB5R2 CYB5R3
13 hemoglobin binding GO:0030492 9.26 HBB HP
14 oxygen binding GO:0019825 8.92 CYP2E1 CYP3A4 HBB HBG2

Sources for Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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