MCID: MTH007
MIFTS: 47

Methemoglobinemia

Categories: Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Methemoglobinemia

Summaries for Methemoglobinemia

MalaCards based summary : Methemoglobinemia is related to hereditary methemoglobinemia and acquired methemoglobinemia, and has symptoms including cyanosis An important gene associated with Methemoglobinemia is CYB5R3 (Cytochrome B5 Reductase 3), and among its related pathways/superpathways are Amino sugar and nucleotide sugar metabolism and Metabolism. The drugs Lidocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and kidney.

Wikipedia : 76 Methemoglobinemia is a condition caused by elevated levels of methemoglobin in the blood. Methemoglobin... more...

Related Diseases for Methemoglobinemia

Diseases in the Methemoglobinemia family:

Methemoglobinemia, Beta Type Methemoglobinemia, Alpha Type
Congenital Methemoglobinemia Hereditary Methemoglobinemia
Acquired Methemoglobinemia

Diseases related to Methemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 hereditary methemoglobinemia 33.9 CYB5A CYB5R3 HBG2
2 acquired methemoglobinemia 33.4 CYB5R3 G6PD HBG2
3 congenital methemoglobinemia 32.7 CYB5A CYB5R3 G6PD HBG2
4 glucosephosphate dehydrogenase deficiency 29.6 G6PD HBG2 HP
5 hemolytic anemia 29.6 G6PD HBG2 HP
6 methemoglobinemia due to deficiency of methemoglobin reductase 12.6
7 methemoglobinemia, beta-globin type 12.5
8 methemoglobinemia and ambiguous genitalia 12.4
9 methemoglobinemia, beta type 12.1
10 methemoglobinemia, alpha type 12.1
11 sickle cell disease 10.2 G6PD HBG2
12 type i 10.2
13 isoniazid toxicity 10.2 CYP2E1 NAT2
14 acetaminophen metabolism 10.1 CYP2E1 CYP3A4
15 methemoglobin reductase deficiency 10.1
16 sulfhemoglobinemia 10.0
17 drug-induced hepatitis 10.0 CYP2E1 NAT2
18 blackwater fever 10.0 G6PD HP
19 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.0 G6PD HP
20 diarrhea 10.0
21 burns 10.0
22 aging 9.9
23 malaria 9.9
24 leukemia 9.9
25 pneumonia 9.9
26 pyruvate dehydrogenase e3-binding protein deficiency 9.9
27 bilirubin metabolic disorder 9.8 G6PD HP
28 alcohol dependence 9.8
29 heinz body anemias 9.8
30 alkaptonuria 9.8
31 enterocolitis 9.8
32 thalassemia 9.8
33 lymphoma 9.8
34 respiratory failure 9.8
35 heart disease 9.8
36 vaginitis 9.8
37 pharyngitis 9.8
38 cervicitis 9.8
39 lupus erythematosus 9.8
40 molluscum contagiosum 9.8
41 hypoxia 9.8
42 congenital hemolytic anemia 9.8 G6PD HP
43 alcoholic liver cirrhosis 9.7 CYP2E1 NAT2
44 alpha-thalassemia 9.7 G6PD HBG2 HP
45 deficiency anemia 9.6 G6PD HBG2 HP
46 burkitt lymphoma 9.6
47 systemic lupus erythematosus 9.6
48 anemia, autoimmune hemolytic 9.6
49 galactorrhea 9.6
50 polycythemia vera 9.6

Graphical network of the top 20 diseases related to Methemoglobinemia:



Diseases related to Methemoglobinemia

Symptoms & Phenotypes for Methemoglobinemia

UMLS symptoms related to Methemoglobinemia:


cyanosis

Drugs & Therapeutics for Methemoglobinemia

Drugs for Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
4
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
5
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068 160954
6
Prilocaine Approved Phase 4,Not Applicable 721-50-6 4906
7
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
8
Methylene blue Approved, Investigational Phase 4,Phase 1 61-73-4
9 Anesthetics Phase 4,Not Applicable
10 Anesthetics, General Phase 4
11 Anesthetics, Intravenous Phase 4
12 Anesthetics, Local Phase 4,Not Applicable
13 Anti-Arrhythmia Agents Phase 4,Not Applicable
14 Central Nervous System Depressants Phase 4,Not Applicable
15 Diuretics, Potassium Sparing Phase 4,Not Applicable
16 Hypnotics and Sedatives Phase 4
17 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
18 Sodium Channel Blockers Phase 4,Not Applicable
19 diuretics Phase 4
20 Epinephryl borate Phase 4,Not Applicable
21 Natriuretic Agents Phase 4
22 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
23
Primaquine Approved Phase 3,Phase 1,Not Applicable 90-34-6 4908
24
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
25
Glycerol Approved, Investigational Phase 3 56-81-5 753
26
Dihydroartemisinin Approved, Investigational Phase 3 71939-50-9 6918483
27
Piperaquine Approved, Investigational Phase 3 4085-31-8 5079497
28 tannic acid Approved, Nutraceutical Phase 3
29 Tafenoquine Investigational Phase 3 106635-80-7
30 Anti-Infective Agents Phase 3,Phase 1,Not Applicable
31 Antimalarials Phase 3,Phase 1,Not Applicable
32 Antiparasitic Agents Phase 3,Phase 1,Not Applicable
33 Antiprotozoal Agents Phase 3,Phase 1,Not Applicable
34 Protective Agents Phase 3
35 Anti-Asthmatic Agents Phase 3,Not Applicable
36 Autonomic Agents Phase 3,Not Applicable
37 Bronchodilator Agents Phase 3,Not Applicable
38 Neurotransmitter Agents Phase 3,Not Applicable
39 Respiratory System Agents Phase 3,Not Applicable
40 Artemisinine Phase 3,Not Applicable
41 Artemisinins Phase 3,Not Applicable
42 Antioxidants Phase 3
43 Endothelium-Dependent Relaxing Factors Phase 3
44 Vasodilator Agents Phase 3
45
Dapsone Approved, Investigational Phase 1 80-08-0 2955
46
Cobicistat Approved Phase 1 1004316-88-4
47
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
48
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
49 Anti-Bacterial Agents Phase 1
50 Folic Acid Antagonists Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol Completed NCT01489891 Phase 4 Lidocaine;Placebo
2 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4 Pyridium;Sodium Fluorescein;Mannitol
3 MEthylene Blue In Patients With Acquired Methemoglobinemia Not yet recruiting NCT03395223 Phase 4 Methylene Blue
4 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media Completed NCT02044341 Phase 3 AR01;Glycerin ear drops
5 Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis Recruiting NCT03053388 Phase 3 Nitric Oxide
6 Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria Recruiting NCT02802501 Phase 3 Tafenoquine;Matched-Placebo for Tafenoquine;Primaquine;Matched-Placebo for Primaquine;Dihydroartemisinin-piperaquine (DHA-PQP);ACT plus PQ (Rescue medication);PQ (End of study treatment)
7 Inhaled Nitric Oxide Study for Respiratory Failure in Newborns Terminated NCT00005776 Phase 3 Inhaled nitric oxide;Placebo
8 Early Inhaled Nitric Oxide for Respiratory Failure in Newborns Terminated NCT00005773 Phase 3 Inhaled Nitric Oxide;Standard iNO therapy
9 Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery Unknown status NCT01098409 Phase 2 sodium nitrite;0.9% sodium chloride
10 Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction Completed NCT01584453 Phase 2 Sodium Nitrite;Sodium Chloride Placebo
11 Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers Recruiting NCT02863068 Phase 2 Topical Sodium Nitrite
12 Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction Terminated NCT01715883 Phase 2 Sodium Nitrite
13 Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration Completed NCT02493283 Phase 1 Dapsone single dose;Dapsone multiple dose
14 Safety, Tolerability, and Pharmacokinetic Study of Methylene Blue Following a 1 mg/kg Intravenous Dose in Healthy Adults Completed NCT02478281 Phase 1 Methylene Blue
15 Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects Completed NCT00000740 Phase 1 Sitamaquine
16 Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency Completed NCT01668433 Phase 1 Regimens (Primaquine, Methylene blue)
17 Nitrite Infusion in Healthy Volunteers Completed NCT00103025 Phase 1 Sodium Nitrite;Sodium Nitrite Injection
18 First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor Recruiting NCT02661373 Phase 1 SJ733;Cobicistat
19 Safety and Efficacy of Primaquine for P. Vivax Unknown status NCT01837992 Not Applicable Primaquine;delayed primaquine
20 Methemoglobinemia After Liposuction - Diagnostic by Pulse Oximetry and Blood Gas Analysis. Completed NCT01766999
21 Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone Completed NCT00993694 chemotherapy;dapsone
22 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics Completed NCT01402869 Not Applicable 4% prilocaine plain;2% Lidocaine with 1:100,000 epinephrine
23 Study of Methemoglobin as a Biomarker of Tissue Hypoxia During Acute Hemodilution in Heart Surgery Patients Completed NCT01883713
24 Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria Completed NCT02528279 Not Applicable Coartem
25 Lidocaine Spray on an Endoscope to Improve Tolerance to Endoscopy Completed NCT02307773 Case Group
26 Acquired Methemoglobinemia Observational Registry Recruiting NCT03542760 Methylene Blue
27 MOM's PAIN (Methylene Blue for Oral Mucositis' PAIN) Not yet recruiting NCT03469284 Early Phase 1 Methylene Blue (MB) 0.025%;Methylene Blue (MB) 0.05%;Methylene Blue (MB) 0.1%

Search NIH Clinical Center for Methemoglobinemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: methemoglobinemia

Genetic Tests for Methemoglobinemia

Anatomical Context for Methemoglobinemia

MalaCards organs/tissues related to Methemoglobinemia:

41
Lung, Heart, Kidney, Skin, Testes, Brain, Liver

Publications for Methemoglobinemia

Articles related to Methemoglobinemia:

(show top 50) (show all 726)
# Title Authors Year
1
Fatal methemoglobinemia complicating alkaptonuria (ochronosis): a rare presentation. ( 29572623 )
2018
2
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. ( 29627919 )
2018
3
Role of Automated Therapeutic Red Cell Exchange in the Setting of Acute Methemoglobinemia: Our Experience. ( 29398814 )
2018
4
Methemoglobinemia in an HIV patient. ( 29522394 )
2018
5
A new mutation of congenital methemoglobinemia exacerbated after methylene blue treatment. ( 29657736 )
2018
6
Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I. ( 29482478 )
2018
7
Benzocaine-Associated Methemoglobinemia. ( 29912717 )
2018
8
Dapsone-induced Methemoglobinemia in a Child with End-stage Renal Disease: A Brief Review. ( 29930890 )
2018
9
Methemoglobinemia: A Girl with 'Chocolate Brown' Colored Blood. ( 29777467 )
2018
10
Local Anesthetic-Induced Methemoglobinemia During Pregnancy: A Case Report and Evaluation of Treatment Options. ( 29519718 )
2018
11
Severe Heinz body anemia and methemoglobinemia in a kitten with chronic diarrhea. ( 29615382 )
2018
12
Methemoglobinemia in a Case of Paint Thinner Intoxication, Treated Successfully with Vitamin C. ( 29258784 )
2018
13
Methemoglobinemia should be suspected when oxygen saturation apparently decreases after prilocaine infiltration during intravenous sedation. ( 29881568 )
2018
14
Severe decrease in SpO<sub>2</sub> and methemoglobinemia following subareolar isosulfan blue administration and clinical relevance. ( 29756115 )
2018
15
Congenital methemoglobinemia misdiagnosed as polycythemia vera: Case report and review of literature. ( 29721250 )
2018
16
Congenital methemoglobinemia type II in a 5-year-old boy. ( 29375859 )
2018
17
Food Protein-Induced Enterocolitis Syndrome Causing Hypovolemic Shock and Methemoglobinemia. ( 29854475 )
2018
18
The first case of methemoglobinemia associated with omalizumab. ( 29339124 )
2018
19
Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene. ( 29356095 )
2018
20
The Acute Treatment of Methemoglobinemia in Pregnancy. ( 29627348 )
2018
21
Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia. ( 28370399 )
2017
22
A Case of Cyanosis: Dapsone Induced Methemoglobinemia and Coexisting Pulmonary Embolism. ( 28418946 )
2017
23
Acquired Methemoglobinemia - A Sporadic Holi Disaster. ( 28667718 )
2017
24
Upward trend of dapsone-induced methemoglobinemia in renal transplant communitya8c. ( 28699887 )
2017
25
Transient Methemoglobinemia in three Neonates due to Maternal Pudendal Anesthesia. ( 29185409 )
2017
26
Benzocaine-Induced Methemoglobinemia. ( 29102098 )
2017
27
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency. ( 28963729 )
2017
28
Cotrimoxazole-induced Methemoglobinemia. ( 28984267 )
2017
29
An Unusual Case of Neonatal Methemoglobinemia. ( 28285300 )
2017
30
A puzzling case of methemoglobinemia. ( 28370418 )
2017
31
Laundry Blues: a case of methemoglobinemia with laundry detergent and Tylenol ingestion. ( 28911028 )
2017
32
Rasburicase-induced methemoglobinemia: The eyes do not see what the mind does not know. ( 28345492 )
2017
33
Methemoglobinemia Due to Antifreeze Ingestion. ( 29141168 )
2017
34
Rare cause of delirium and hypoxemia after coronary bypass surgery: transdermal lidocaine patch-associated methemoglobinemia. ( 28875384 )
2017
35
Enzymopenic Congenital Methemoglobinemia in Children of the Republic of Sakha (Yakutia). ( 27879543 )
2017
36
Methylene Blue Induced Methemoglobinemia with Acute Kidney Injury in a Glucose-6-Phosphate Dehydrogenase-deficient Patient. ( 29217886 )
2017
37
Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury. ( 28969436 )
2017
38
A Case of Methemoglobinemia Successfully Treated with Hyperbaric Oxygenation Monotherapy. ( 28838565 )
2017
39
Plasmapheresis in severe methemoglobinemia following occupational exposure. ( 28259531 )
2017
40
Primaquine in Plasma and Methemoglobinemia in Patients with Malaria Due to Plasmodium vivax in the Brazilian Amazon Basin. ( 28440745 )
2017
41
Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl. ( 28765205 )
2017
42
Inhaled nitric oxide, methemoglobinemia, and route of delivery. ( 28757849 )
2017
43
Rasburicase-Induced Methemoglobinemia in a Patient with Glucose-6-Phosphate Dehydrogenase Deficiency. ( 28078984 )
2017
44
Successful treatment of NO-induced methemoglobinemia with low-dose vitamin C. ( 28438052 )
2017
45
Methemoglobinemia Caused by Indoxacarb Poisoning. ( 28641724 )
2017
46
Methemoglobinemia After Paracetamol Ingestion: A Case Report. ( 29268071 )
2017
47
Prilocaine-induced Methemoglobinemia. ( 28903852 )
2017
48
Anesthetic management of congenital methemoglobinemia in an emergency cesarean section. ( 29109650 )
2017
49
Hemolysis and Methemoglobinemia in a Child With Membrane Oxygenator on Biventricular Assist Device. ( 28782159 )
2017
50
A Case Report of Benzocaine-Induced Methemoglobinemia. ( 28803519 )
2017

Variations for Methemoglobinemia

ClinVar genetic disease variations for Methemoglobinemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 subset of 22 genes:FLCN; RAI1 GRCh37/hg19 17p11.2(chr17: 16936603-18184130) copy number loss Pathogenic GRCh37 Chromosome 17, 16936603: 18184130

Expression for Methemoglobinemia

Search GEO for disease gene expression data for Methemoglobinemia.

Pathways for Methemoglobinemia

Pathways related to Methemoglobinemia according to KEGG:

37
# Name Kegg Source Accession
1 Amino sugar and nucleotide sugar metabolism hsa00520

Pathways related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 CYB5A CYB5R2 CYB5R3 CYB5R4 CYP2E1 CYP3A4
2
Show member pathways
12.5 CYB5A CYB5R2 CYB5R3 CYB5R4 CYP2E1 CYP3A4
3
Show member pathways
11.43 CYP2E1 CYP3A4
4
Show member pathways
11.42 CYP2E1 CYP3A4
5
Show member pathways
11.32 CYP2E1 CYP3A4
6
Show member pathways
11.32 CYB5R2 CYB5R3 CYB5R4
7
Show member pathways
11.28 CYP2E1 CYP3A4
8
Show member pathways
11.23 CYP2E1 CYP3A4
9 11 CYP2E1 CYP3A4
10
Show member pathways
10.98 CYB5R2 CYB5R4
11 10.78 CYP2E1 CYP3A4
12
Show member pathways
10.76 CYP2E1 CYP3A4 NAT2
13 10.67 CYP2E1 CYP3A4
14 9.4 CYB5A CYB5R3 G6PD

GO Terms for Methemoglobinemia

Cellular components related to Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.65 CYB5A CYB5R3 CYB5R4 CYP2E1 CYP3A4
2 intracellular membrane-bounded organelle GO:0043231 9.62 CYB5A CYP2E1 CYP3A4 G6PD
3 hemoglobin complex GO:0005833 9.16 CYB5R3 HBG2
4 organelle membrane GO:0031090 9.13 CYB5A CYP2E1 CYP3A4
5 endoplasmic reticulum membrane GO:0005789 9.1 CYB5A CYB5R2 CYB5R3 CYB5R4 CYP2E1 CYP3A4

Biological processes related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.71 CYB5R2 CYB5R3 CYP3A4 G6PD
2 steroid biosynthetic process GO:0006694 9.52 CYB5R2 CYB5R3
3 bicarbonate transport GO:0015701 9.51 CYB5R2 CYB5R4
4 cholesterol biosynthetic process GO:0006695 9.49 CYB5R3 G6PD
5 sterol biosynthetic process GO:0016126 9.48 CYB5R2 CYB5R3
6 drug metabolic process GO:0017144 9.46 CYP2E1 CYP3A4
7 steroid metabolic process GO:0008202 9.46 CYB5R2 CYB5R3 CYP2E1 CYP3A4
8 exogenous drug catabolic process GO:0042738 9.43 CYP2E1 CYP3A4
9 L-ascorbic acid metabolic process GO:0019852 9.37 CYB5A CYB5R3
10 heterocycle metabolic process GO:0046483 9.32 CYP2E1 CYP3A4
11 monoterpenoid metabolic process GO:0016098 9.26 CYP2E1 CYP3A4
12 xenobiotic metabolic process GO:0006805 9.26 CYB5R3 CYP2E1 CYP3A4 NAT2
13 oxidation-reduction process GO:0055114 9.17 CYB5A CYB5R2 CYB5R3 CYB5R4 CYP2E1 CYP3A4

Molecular functions related to Methemoglobinemia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.65 CYB5A CYP2E1 CYP3A4
2 oxidoreductase activity GO:0016491 9.63 CYB5R2 CYB5R3 CYB5R4 CYP2E1 CYP3A4 G6PD
3 iron ion binding GO:0005506 9.54 CYP2E1 CYP3A4 HBG2
4 oxygen binding GO:0019825 9.5 CYP2E1 CYP3A4 HBG2
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.49 CYP2E1 CYP3A4
6 monooxygenase activity GO:0004497 9.46 CYP2E1 CYP3A4
7 steroid hydroxylase activity GO:0008395 9.43 CYP2E1 CYP3A4
8 FAD binding GO:0071949 9.43 CYB5R2 CYB5R3 CYB5R4
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.4 CYP2E1 CYP3A4
10 cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 9.13 CYB5R2 CYB5R3 CYB5R4
11 heme binding GO:0020037 9.02 CYB5A CYB5R4 CYP2E1 CYP3A4 HBG2

Sources for Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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