MCST
MCID: MCR379
MIFTS: 30

Microcystic Stromal Tumor (MCST)

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Microcystic Stromal Tumor

MalaCards integrated aliases for Microcystic Stromal Tumor:

Name: Microcystic Stromal Tumor 58
Mcst 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Orphanet 58 ORPHA569248

Summaries for Microcystic Stromal Tumor

MalaCards based summary : Microcystic Stromal Tumor, also known as mcst, is related to wilms tumor 5 and wilms tumor 1. An important gene associated with Microcystic Stromal Tumor is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Primary Focal Segmental Glomerulosclerosis FSGS. The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include testes, ovary and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Microcystic Stromal Tumor

Diseases related to Microcystic Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 wilms tumor 5 30.6 WT1 CTNNB1
2 wilms tumor 1 28.4 WT1 NR5A1 DICER1 CTNNB1 CCND1
3 rare tumor 10.3
4 dementia 10.3
5 familial adenomatous polyposis 10.2
6 mullerian aplasia and hyperandrogenism 10.2 FOXL2 CTNNB1
7 polymorphous low-grade adenocarcinoma 10.1 CTNNB1 CCND1
8 endometrioid ovary carcinoma 10.1 WT1 CTNNB1
9 hemimegalencephaly 10.1 CTNNB1 CCND1
10 bone squamous cell carcinoma 10.1 CTNNB1 CCND1
11 female reproductive endometrioid cancer 10.1 WT1 CTNNB1
12 respiratory system benign neoplasm 10.1 CTNNB1 CCND1
13 mixed cell type cancer 10.1 WT1 CTNNB1
14 esophagus adenocarcinoma 10.1 CTNNB1 CCND1
15 desmoid tumor 10.1 CTNNB1 CCND1
16 uterine benign neoplasm 10.1 CTNNB1 CCND1
17 reproductive organ benign neoplasm 10.1 CTNNB1 CCND1
18 colonic benign neoplasm 10.1 CTNNB1 CCND1
19 uterine corpus cancer 10.1 WT1 CTNNB1
20 childhood medulloblastoma 10.0 CTNNB1 CCND1
21 oropharynx cancer 10.0 CTNNB1 CCND1
22 maligant granulosa cell tumor of the ovary 10.0 FOXL2 DICER1
23 gynandroblastoma 10.0 FOXL2 DICER1
24 atypical teratoid rhabdoid tumor 10.0 CTNNB1 CCND1
25 rhabdoid cancer 10.0 WT1 CCND1
26 serous cystadenocarcinoma 10.0 WT1 CTNNB1
27 dysgerminoma 10.0 WT1 FOXL2
28 lymphangioma 10.0 CTNNB1 CCND1
29 fanconi anemia, complementation group d2 10.0
30 cystadenoma 10.0
31 cystic teratoma 10.0
32 teratoma 10.0
33 pre-malignant neoplasm 10.0 CTNNB1 CCND1
34 basal cell nevus syndrome 10.0 CTNNB1 CCND1
35 kidney sarcoma 10.0 WT1 DICER1
36 endometrial adenocarcinoma 10.0 CTNNB1 CCND1
37 wilms tumor predisposition 10.0 WT1 DICER1
38 kidney cortex disease 10.0 WT1 DICER1
39 in situ carcinoma 10.0 CTNNB1 CCND1
40 kidney benign neoplasm 9.9 WT1 DICER1
41 clear cell sarcoma 9.9 WT1 CCND1
42 nephroma 9.9 WT1 DICER1
43 wilson-turner x-linked mental retardation syndrome 9.9 WT1 CTNNB1
44 chronic leukemia 9.9 WT1 CCND1
45 parathyroid adenoma 9.9 CTNNB1 CCND1
46 breast carcinoma in situ 9.9 CTNNB1 CCND1
47 intestinal benign neoplasm 9.9 CTNNB1 CCND1
48 carcinosarcoma 9.9 WT1 CTNNB1
49 mixed gonadal dysgenesis 9.9 NR5A1 FOXL2
50 46,xx sex reversal 9.8 NR5A1 FOXL2

Graphical network of the top 20 diseases related to Microcystic Stromal Tumor:



Diseases related to Microcystic Stromal Tumor

Symptoms & Phenotypes for Microcystic Stromal Tumor

GenomeRNAi Phenotypes related to Microcystic Stromal Tumor according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.4 CCND1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.4 DICER1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.4 CCND1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 DICER1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.4 CCND1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.4 CCND1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.4 CCND1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.4 CCND1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.4 DICER1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.4 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 DICER1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.4 DICER1

MGI Mouse Phenotypes related to Microcystic Stromal Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.93 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
2 growth/size/body region MP:0005378 9.91 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
3 cardiovascular system MP:0005385 9.88 CCND1 CTNNB1 DICER1 NR5A1 WT1
4 homeostasis/metabolism MP:0005376 9.88 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
5 mortality/aging MP:0010768 9.85 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
6 normal MP:0002873 9.63 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
7 neoplasm MP:0002006 9.62 CCND1 CTNNB1 DICER1 WT1
8 no phenotypic analysis MP:0003012 9.56 CTNNB1 DICER1 FOXL2 WT1
9 reproductive system MP:0005389 9.43 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
10 respiratory system MP:0005388 8.92 CCND1 CTNNB1 DICER1 WT1

Drugs & Therapeutics for Microcystic Stromal Tumor

Drugs for Microcystic Stromal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Addition of Cardiac Computed Tomography to Exercise Treadmill Testing in the Evaluation of Angina Unknown status NCT00491218
2 Efficacy of Metacognitive-Strategy Training to Improve Activity Performance and Reduce Motor Impairment in Sub-Acute Stroke Recruiting NCT04099511
3 Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging Recruiting NCT03807167

Search NIH Clinical Center for Microcystic Stromal Tumor

Genetic Tests for Microcystic Stromal Tumor

Anatomical Context for Microcystic Stromal Tumor

MalaCards organs/tissues related to Microcystic Stromal Tumor:

40
Testes, Ovary, Cortex, Prefrontal Cortex, Cingulate Cortex

Publications for Microcystic Stromal Tumor

Articles related to Microcystic Stromal Tumor:

(show top 50) (show all 88)
# Title Authors PMID Year
1
Modified Chester Step Test in a Healthy Adult Population: Measurement Properties and Development of a Regression Equation to Estimate Test Duration. 61
32383770 2020
2
Group-based cognitive stimulation therapy for dementia: a qualitative study on experiences of group interactions. 61
32272849 2020
3
On the dynamics of a curved microtubule-associated proteins by considering viscoelastic properties of the living biological cells. 61
32242501 2020
4
Integrated neurocognitive therapy in chronic schizophrenic inpatients: preliminary data and considerations. 61
32051623 2020
5
Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics. 61
31846522 2020
6
Ovarian Microcystic Stromal Tumor: A Case Report and Literature Review. 61
32158762 2020
7
Cognitive abilities underlying performance on the modified card sorting test: novel and traditional scores. 61
31530030 2019
8
A cost effectiveness analysis of maintenance cognitive stimulation therapy (MCST) for people with dementia: examining the influence of cognitive ability and living arrangements. 61
29528689 2019
9
Structural basis for mammalian nucleotide sugar transport. 61
30985278 2019
10
Size-Dependent Free Vibration and Buckling of Three-Dimensional Graphene Foam Microshells Based on Modified Couple Stress Theory. 61
30832376 2019
11
Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD. 61
30500284 2018
12
Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review. 61
29169232 2018
13
Neuropsychological correlates of cognitive, emotional-affective and auto-activation apathy in Alzheimer's disease. 61
29407942 2018
14
Ovarian microcystic stromal tumor: Radiologic-pathologic correlation. 61
30014019 2018
15
Ovarian microcystic stromal tumor with undetermined potential: case study with molecular analysis and literature review. 61
29458068 2018
16
Insufficiency of the Young's modulus for illustrating the mechanical behavior of GaN nanowires. 61
29473824 2018
17
Which tasks measure what? Reflections on executive function development and a commentary on Podjarny, Kamawar, and Andrews (2017). 61
29197781 2018
18
Microcystic stromal tumor resected by laparoscopic surgery. 61
30254899 2017
19
CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation. 61
28551672 2017
20
Structural studies of the bond-orientational order and hexatic-smectic transition in liquid crystals of various compositions. 61
28402369 2017
21
[Microcystic stromal tumor of ovary during pregnancy: report of a case]. 61
28297766 2017
22
Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary. 61
27830327 2017
23
Microcystic Stromal Tumor of the Ovary. 61
28292393 2017
24
Ovarian Microcystic Stromal Tumor: A Rare Clinical Manifestation of Familial Adenomatous Polyposis. 61
27015438 2016
25
Differential expression of E-cadherin and catenins in ovarian sex cord stromal tumours. 61
27097978 2016
26
Monothermal Caloric Screening Test Accuracy: A Systematic Review. 61
26932962 2016
27
Genetic analysis of ovarian microcystic stromal tumor. 61
27004209 2016
28
Three new strategies to improve the accuracy of monothermal caloric screening testing. 61
26032765 2016
29
CTNNB1 (β-Catenin)-altered Neoplasia: A Review Focusing on Soft Tissue Neoplasms and Parenchymal Lesions of Uncertain Histogenesis. 61
26645457 2016
30
The Feasibility of Using Metacognitive Strategy Training to Improve Cognitive Performance and Neural Connectivity in Women with Chemotherapy-Induced Cognitive Impairment. 61
27449501 2016
31
Microcystic stromal tumour of the ovary: frequent mutations of β-catenin (CTNNB1) in six cases. 61
25913412 2015
32
Microcystic Stromal Tumor of the Ovary: A Case Report of a Newly Described Ovarian Neoplasm With a β-catenin (CTNNB1) G34E Mutation. 61
26107566 2015
33
Coexistence of Microcystic Stromal Tumor of the Ovary With Mutation of β-Catenin and Contralateral Mucinous Cystadenoma. 61
26444252 2015
34
Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations. 61
26200099 2015
35
Ovarian microcystic stromal tumor: A novel extracolonic tumor in familial adenomatous polyposis. 61
25820106 2015
36
Microcystic stromal tumor of the ovary with mutation in exon 3 of β-catenin: a case report. 61
25675179 2015
37
Vibration of bioliquid-filled microtubules embedded in cytoplasm including surface effects using modified couple stress theory. 61
25479416 2015
38
Overlap of microcystic stromal tumor and primary solid pseudopapillary neoplasm of the ovary. 61
26617928 2015
39
Monitoring supports performance in a dual-task paradigm involving a risky decision-making task and a working memory task. 61
25741308 2015
40
Lesion load may predict long-term cognitive dysfunction in multiple sclerosis patients. 61
25816303 2015
41
Ovarian tumors and tumor-like lesions in the first three decades. 61
25440719 2014
42
Thecoma of the ovary: a report of 70 cases emphasizing aspects of its histopathology different from those often portrayed and its differential diagnosis. 61
25025365 2014
43
Ovarian microcystic stromal tumor: report of a new entity with immunohistochemical and ultrastructural studies. 61
24684527 2014
44
Correlates of insight with symptomatology and executive function in patients with first-episode schizophrenia-spectrum disorder: a longitudinal perspective. 61
24560612 2014
45
Rule-based category learning in Down syndrome. 61
24871791 2014
46
The effects of a Cognitive Stimulation Therapy [CST] programme for people with dementia on family caregivers' health. 61
24628705 2014
47
The effect of learning on feedback-related potentials in adolescents with dyslexia: an EEG-ERP study. 61
24950233 2014
48
Cognition and emotional decision-making in chronic low back pain: an ERPs study during Iowa gambling task. 61
25505440 2014
49
Chilean version of the INECO Frontal Screening (IFS-Ch): psychometric properties and diagnostic accuracy. 61
29213818 2013
50
Cognitive correlates of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression--a pilot study. 61
23031294 2012

Variations for Microcystic Stromal Tumor

Expression for Microcystic Stromal Tumor

Search GEO for disease gene expression data for Microcystic Stromal Tumor.

Pathways for Microcystic Stromal Tumor

GO Terms for Microcystic Stromal Tumor

Biological processes related to Microcystic Stromal Tumor according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.83 WT1 NR5A1 FOXL2 CTNNB1
2 regulation of transcription by RNA polymerase II GO:0006357 9.78 WT1 NR5A1 FOXL2 CTNNB1
3 positive regulation of gene expression GO:0010628 9.72 WT1 NR5A1 CTNNB1
4 positive regulation of transcription, DNA-templated GO:0045893 9.62 WT1 NR5A1 FOXL2 CTNNB1
5 vasculogenesis GO:0001570 9.54 WT1 CTNNB1
6 tissue development GO:0009888 9.51 WT1 NR5A1
7 branching involved in ureteric bud morphogenesis GO:0001658 9.49 WT1 CTNNB1
8 female gonad development GO:0008585 9.46 NR5A1 FOXL2
9 adrenal gland development GO:0030325 9.43 WT1 NR5A1
10 male genitalia development GO:0030539 9.4 WT1 CTNNB1
11 apoptotic DNA fragmentation GO:0006309 9.37 FOXL2 DICER1
12 negative regulation of transcription by RNA polymerase II GO:0000122 9.35 WT1 FOXL2 DICER1 CTNNB1 CCND1
13 positive regulation of male gonad development GO:2000020 9.26 WT1 NR5A1
14 sex determination GO:0007530 9.16 WT1 NR5A1
15 negative regulation of female gonad development GO:2000195 8.62 WT1 NR5A1

Molecular functions related to Microcystic Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 NR5A1 CTNNB1 CCND1
2 estrogen receptor binding GO:0030331 8.96 FOXL2 CTNNB1
3 DNA-binding transcription factor activity GO:0003700 8.92 WT1 NR5A1 FOXL2 CTNNB1

Sources for Microcystic Stromal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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