MCST
MCID: MCR379
MIFTS: 29

Microcystic Stromal Tumor (MCST)

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Microcystic Stromal Tumor

MalaCards integrated aliases for Microcystic Stromal Tumor:

Name: Microcystic Stromal Tumor 58
Mcst 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Orphanet 58 ORPHA569248

Summaries for Microcystic Stromal Tumor

MalaCards based summary : Microcystic Stromal Tumor, also known as mcst, is related to wilms tumor 1 and rare tumor. An important gene associated with Microcystic Stromal Tumor is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include ovary, cortex and prefrontal cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Microcystic Stromal Tumor

Diseases related to Microcystic Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 wilms tumor 1 29.2 WT1 NR5A1 DICER1 CTNNB1
2 rare tumor 10.4
3 familial adenomatous polyposis 10.2
4 mullerian aplasia and hyperandrogenism 10.1 FOXL2 CTNNB1
5 mammary analogue secretory carcinoma 10.1 CTNNB1 CCND1
6 polymorphous low-grade adenocarcinoma 10.1 CTNNB1 CCND1
7 endometrioid ovary carcinoma 10.1 WT1 CTNNB1
8 bone squamous cell carcinoma 10.1 CTNNB1 CCND1
9 hemimegalencephaly 10.1 CTNNB1 CCND1
10 female reproductive endometrioid cancer 10.1 WT1 CTNNB1
11 maligant granulosa cell tumor of the ovary 10.1 FOXL2 DICER1
12 respiratory system benign neoplasm 10.1 CTNNB1 CCND1
13 gynandroblastoma 10.1 FOXL2 DICER1
14 uterine benign neoplasm 10.1 CTNNB1 CCND1
15 reproductive organ benign neoplasm 10.1 CTNNB1 CCND1
16 desmoid tumor 10.1 CTNNB1 CCND1
17 uterine corpus cancer 10.1 WT1 CTNNB1
18 colonic benign neoplasm 10.0 CTNNB1 CCND1
19 childhood medulloblastoma 10.0 CTNNB1 CCND1
20 oropharynx cancer 10.0 CTNNB1 CCND1
21 ovary adenocarcinoma 10.0 WT1 CTNNB1
22 parathyroid carcinoma 10.0 CTNNB1 CCND1
23 pre-malignant neoplasm 10.0 CTNNB1 CCND1
24 lymphangioma 10.0 CTNNB1 CCND1
25 fanconi anemia, complementation group d2 10.0
26 cystadenoma 10.0
27 clear cell sarcoma 10.0 WT1 CCND1
28 in situ carcinoma 10.0 CTNNB1 CCND1
29 chronic leukemia 10.0 WT1 CCND1
30 kidney sarcoma 10.0 WT1 DICER1
31 endometrial adenocarcinoma 10.0 CTNNB1 CCND1
32 wilms tumor predisposition 10.0 WT1 DICER1
33 kidney cortex disease 10.0 WT1 DICER1
34 rhabdoid cancer 10.0 WT1 CCND1
35 wilson-turner x-linked mental retardation syndrome 10.0 WT1 CTNNB1
36 kidney benign neoplasm 10.0 WT1 DICER1
37 breast carcinoma in situ 10.0 CTNNB1 CCND1
38 nephroma 10.0 WT1 DICER1
39 sertoli-leydig cell tumor 10.0 WT1 DICER1
40 parathyroid adenoma 10.0 CTNNB1 CCND1
41 carney complex variant 10.0 DICER1 CTNNB1
42 intestinal benign neoplasm 10.0 CTNNB1 CCND1
43 dementia 10.0
44 endometrial hyperplasia 10.0 CTNNB1 CCND1
45 skeletal muscle cancer 9.9 WT1 DICER1
46 infratentorial cancer 9.9 CTNNB1 CCND1
47 mixed gonadal dysgenesis 9.9 NR5A1 FOXL2
48 46,xx sex reversal 9.9 NR5A1 FOXL2
49 46 xx gonadal dysgenesis 9.9 NR5A1 FOXL2
50 blepharophimosis, ptosis, and epicanthus inversus 9.9 NR5A1 FOXL2

Graphical network of the top 20 diseases related to Microcystic Stromal Tumor:



Diseases related to Microcystic Stromal Tumor

Symptoms & Phenotypes for Microcystic Stromal Tumor

GenomeRNAi Phenotypes related to Microcystic Stromal Tumor according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.4 CCND1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.4 DICER1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.4 CCND1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 DICER1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.4 CCND1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.4 CCND1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.4 CCND1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.4 CCND1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.4 DICER1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.4 CTNNB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 DICER1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.4 DICER1

MGI Mouse Phenotypes related to Microcystic Stromal Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.93 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
2 growth/size/body region MP:0005378 9.91 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
3 homeostasis/metabolism MP:0005376 9.88 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
4 mortality/aging MP:0010768 9.85 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
5 normal MP:0002873 9.63 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
6 neoplasm MP:0002006 9.62 CCND1 CTNNB1 DICER1 WT1
7 no phenotypic analysis MP:0003012 9.56 CTNNB1 DICER1 FOXL2 WT1
8 reproductive system MP:0005389 9.43 CCND1 CTNNB1 DICER1 FOXL2 NR5A1 WT1
9 respiratory system MP:0005388 8.92 CCND1 CTNNB1 DICER1 WT1

Drugs & Therapeutics for Microcystic Stromal Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Mobile COPD Status Test (mCST) - Investigation of the Correlation of a Digital Measurement With Disease Relevant Endpoints in Patients With COPD Recruiting NCT04457843
2 Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging Recruiting NCT03807167

Search NIH Clinical Center for Microcystic Stromal Tumor

Genetic Tests for Microcystic Stromal Tumor

Anatomical Context for Microcystic Stromal Tumor

MalaCards organs/tissues related to Microcystic Stromal Tumor:

40
Ovary, Cortex, Prefrontal Cortex, Cingulate Cortex

Publications for Microcystic Stromal Tumor

Articles related to Microcystic Stromal Tumor:

(show top 50) (show all 90)
# Title Authors PMID Year
1
Deficits in executive functions but not in decision making under risk in individuals with problematic social-network use. 61
33581450 2021
2
Quasi-3D Hyperbolic Shear Deformation Theory for the Free Vibration Study of Honeycomb Microplates with Graphene Nanoplatelets-Reinforced Epoxy Skins. 61
33147816 2020
3
Ovarian microcystic stromal tumor with significant bizarre nuclei: A case report. 61
32846831 2020
4
Modified Chester Step Test in a Healthy Adult Population: Measurement Properties and Development of a Regression Equation to Estimate Test Duration. 61
32383770 2020
5
Group-based cognitive stimulation therapy for dementia: a qualitative study on experiences of group interactions. 61
32272849 2020
6
On the dynamics of a curved microtubule-associated proteins by considering viscoelastic properties of the living biological cells. 61
32242501 2020
7
Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli-Leydig cell tumour, microcystic stromal tumour and their mimics. 61
31846522 2020
8
Integrated neurocognitive therapy in chronic schizophrenic inpatients: preliminary data and considerations. 61
32051623 2020
9
Ovarian Microcystic Stromal Tumor: A Case Report and Literature Review. 61
32158762 2020
10
Cognitive abilities underlying performance on the modified card sorting test: novel and traditional scores. 61
31530030 2019
11
A cost effectiveness analysis of maintenance cognitive stimulation therapy (MCST) for people with dementia: examining the influence of cognitive ability and living arrangements. 61
29528689 2019
12
Structural basis for mammalian nucleotide sugar transport. 61
30985278 2019
13
Size-Dependent Free Vibration and Buckling of Three-Dimensional Graphene Foam Microshells Based on Modified Couple Stress Theory. 61
30832376 2019
14
Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD. 61
30500284 2018
15
Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review. 61
29169232 2018
16
Neuropsychological correlates of cognitive, emotional-affective and auto-activation apathy in Alzheimer's disease. 61
29407942 2018
17
Ovarian microcystic stromal tumor with undetermined potential: case study with molecular analysis and literature review. 61
29458068 2018
18
Ovarian microcystic stromal tumor: Radiologic-pathologic correlation. 61
30014019 2018
19
Insufficiency of the Young's modulus for illustrating the mechanical behavior of GaN nanowires. 61
29473824 2018
20
Which tasks measure what? Reflections on executive function development and a commentary on Podjarny, Kamawar, and Andrews (2017). 61
29197781 2018
21
Microcystic stromal tumor resected by laparoscopic surgery. 61
30254899 2017
22
CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation. 61
28551672 2017
23
Structural studies of the bond-orientational order and hexatic-smectic transition in liquid crystals of various compositions. 61
28402369 2017
24
[Microcystic stromal tumor of ovary during pregnancy: report of a case]. 61
28297766 2017
25
Microcystic Stromal Tumor of the Ovary. 61
28292393 2017
26
Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary. 61
27830327 2017
27
Ovarian Microcystic Stromal Tumor: A Rare Clinical Manifestation of Familial Adenomatous Polyposis. 61
27015438 2016
28
Differential expression of E-cadherin and catenins in ovarian sex cord stromal tumours. 61
27097978 2016
29
Monothermal Caloric Screening Test Accuracy: A Systematic Review. 61
26932962 2016
30
Genetic analysis of ovarian microcystic stromal tumor. 61
27004209 2016
31
Three new strategies to improve the accuracy of monothermal caloric screening testing. 61
26032765 2016
32
CTNNB1 (β-Catenin)-altered Neoplasia: A Review Focusing on Soft Tissue Neoplasms and Parenchymal Lesions of Uncertain Histogenesis. 61
26645457 2016
33
The Feasibility of Using Metacognitive Strategy Training to Improve Cognitive Performance and Neural Connectivity in Women with Chemotherapy-Induced Cognitive Impairment. 61
27449501 2016
34
Microcystic stromal tumour of the ovary: frequent mutations of β-catenin (CTNNB1) in six cases. 61
25913412 2015
35
Microcystic Stromal Tumor of the Ovary: A Case Report of a Newly Described Ovarian Neoplasm With a β-catenin (CTNNB1) G34E Mutation. 61
26107566 2015
36
Coexistence of Microcystic Stromal Tumor of the Ovary With Mutation of β-Catenin and Contralateral Mucinous Cystadenoma. 61
26444252 2015
37
Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations. 61
26200099 2015
38
Ovarian microcystic stromal tumor: A novel extracolonic tumor in familial adenomatous polyposis. 61
25820106 2015
39
Microcystic stromal tumor of the ovary with mutation in exon 3 of β-catenin: a case report. 61
25675179 2015
40
Vibration of bioliquid-filled microtubules embedded in cytoplasm including surface effects using modified couple stress theory. 61
25479416 2015
41
Overlap of microcystic stromal tumor and primary solid pseudopapillary neoplasm of the ovary. 61
26617928 2015
42
Lesion load may predict long-term cognitive dysfunction in multiple sclerosis patients. 61
25816303 2015
43
Monitoring supports performance in a dual-task paradigm involving a risky decision-making task and a working memory task. 61
25741308 2015
44
Ovarian tumors and tumor-like lesions in the first three decades. 61
25440719 2014
45
Thecoma of the ovary: a report of 70 cases emphasizing aspects of its histopathology different from those often portrayed and its differential diagnosis. 61
25025365 2014
46
Ovarian microcystic stromal tumor: report of a new entity with immunohistochemical and ultrastructural studies. 61
24684527 2014
47
Correlates of insight with symptomatology and executive function in patients with first-episode schizophrenia-spectrum disorder: a longitudinal perspective. 61
24560612 2014
48
Rule-based category learning in Down syndrome. 61
24871791 2014
49
The effects of a Cognitive Stimulation Therapy [CST] programme for people with dementia on family caregivers' health. 61
24628705 2014
50
The effect of learning on feedback-related potentials in adolescents with dyslexia: an EEG-ERP study. 61
24950233 2014

Variations for Microcystic Stromal Tumor

Expression for Microcystic Stromal Tumor

Search GEO for disease gene expression data for Microcystic Stromal Tumor.

Pathways for Microcystic Stromal Tumor

GO Terms for Microcystic Stromal Tumor

Biological processes related to Microcystic Stromal Tumor according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.73 WT1 DICER1 CTNNB1 CCND1
2 positive regulation of transcription, DNA-templated GO:0045893 9.71 WT1 NR5A1 FOXL2 CTNNB1
3 positive regulation of gene expression GO:0010628 9.69 WT1 NR5A1 CTNNB1
4 vasculogenesis GO:0001570 9.49 WT1 CTNNB1
5 tissue development GO:0009888 9.48 WT1 NR5A1
6 branching involved in ureteric bud morphogenesis GO:0001658 9.46 WT1 CTNNB1
7 adrenal gland development GO:0030325 9.37 WT1 NR5A1
8 male genitalia development GO:0030539 9.32 WT1 CTNNB1
9 apoptotic DNA fragmentation GO:0006309 9.26 FOXL2 DICER1
10 positive regulation of male gonad development GO:2000020 9.16 WT1 NR5A1
11 sex determination GO:0007530 8.96 WT1 NR5A1
12 negative regulation of female gonad development GO:2000195 8.62 WT1 NR5A1

Molecular functions related to Microcystic Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 WT1 NR5A1 FOXL2
2 enzyme binding GO:0019899 8.8 NR5A1 CTNNB1 CCND1

Sources for Microcystic Stromal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....