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MCID: MCR018
MIFTS: 43

Microcytic Anemia

Categories: Blood diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Microcytic Anemia

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MalaCards integrated aliases for Microcytic Anemia:

Name: Microcytic Anemia 12 29 55 6 15
Iron-Refractory Iron Deficiency Anemia 44 73

Classifications:

MalaCards categories:
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11252
MeSH 44 C562385
NCIt 50 C35141
UMLS 73 C0085576
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Summaries for Microcytic Anemia

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MalaCards based summary : Microcytic Anemia, also known as iron-refractory iron deficiency anemia, is related to hypochromic microcytic anemia with iron overload and iron-refractory iron deficiency anemia. An important gene associated with Microcytic Anemia is TMPRSS6 (Transmembrane Serine Protease 6), and among its related pathways/superpathways are Glucose / Energy Metabolism and Insulin receptor recycling. The drugs Iron and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Microcytic anaemia is any of several types of anaemia characterized by small red blood cells (called... more...

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Related Diseases for Microcytic Anemia

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Diseases related to Microcytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 hypochromic microcytic anemia with iron overload 34.9 SLC11A2 STEAP3
2 iron-refractory iron deficiency anemia 33.2 EPO TMPRSS6
3 hypochromic microcytic anemia 33.1 HBA2 SLC11A2 STEAP3 TF TMPRSS6
4 atransferrinemia 32.0 ALAS2 SLC11A2 TF TFRC
5 anemia, sideroblastic, 1 31.6 ACO1 ALAS2 TFRC
6 hemosiderosis 30.1 EPO SLC11A2 TF TFRC
7 iron metabolism disease 29.3 EPO IREB2 SLC11A2 TF TFRC
8 iron deficiency anemia 29.1 EPO SLC11A2 TF TFRC TMPRSS6
9 alpha-thalassemia 28.4 EPO HBA1 HBA2 TFRC
10 thalassemia 28.4 EPO HBA1 HBA2 TF TFRC
11 beta-thalassemia 27.9 EPO HBA1 HBA2 TF TFRC
12 deficiency anemia 27.3 ALAS2 CAT EPO HBA2 SLC11A2 TF
13 autoinflammation, lipodystrophy, and dermatosis syndrome 12.0
14 anemia, hypochromic microcytic, with iron overload 1 11.6
15 anemia, hypochromic microcytic, with iron overload 2 11.3
16 sialuria 11.1
17 3-methylglutaconic aciduria, type v 11.1
18 anemia, congenital dyserythropoietic, type iii 11.0
19 fetal hemoglobin quantitative trait locus 1 11.0
20 5-oxoprolinase deficiency 11.0
21 anemia, sideroblastic, and spinocerebellar ataxia 11.0
22 majeed syndrome 11.0
23 macrocytic anemia 11.0
24 metal metabolism disorder 10.3 SLC11A2 TF TFRC
25 toxic optic neuropathy 10.3 CAT EPO
26 refractory anemia 10.2 ALAS2 EPO
27 fetal erythroblastosis 10.2 EPO TFRC
28 neonatal anemia 10.1 EPO HBA2
29 acquired polycythemia 10.1 ACO1 EPO
30 ehrlichiosis 10.1 ACO1 TFRC
31 hepatitis 10.0
32 folic acid deficiency anemia 10.0 EPO TF TFRC
33 pure red-cell aplasia 10.0 EPO TF
34 immune system disease 10.0 EPO TF TFRC
35 celiac disease 1 10.0
36 renal tubular acidosis 10.0
37 mucositis 10.0
38 castleman disease 10.0
39 panniculitis 10.0
40 unicentric castleman disease 10.0
41 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 9.9 HBA1 HBA2
42 methemoglobinemia, beta-globin type 9.9 HBA1 HBA2
43 hydrops fetalis, nonimmune 9.9 HBA1 HBA2
44 diabetes mellitus, insulin-dependent, 24 9.9 HBA1 HBA2
45 glutathione peroxidase deficiency 9.9 HBA1 HBA2
46 analbuminemia 9.9 EPO TF
47 hypoglycemic coma 9.9 HBA1 HBA2
48 congenital hemolytic anemia 9.8 EPO HBA2 TF
49 heinz body anemias 9.8 HBA1 HBA2
50 type 1 diabetes mellitus 7 9.8 HBA1 HBA2

Graphical network of the top 20 diseases related to Microcytic Anemia:



Diseases related to Microcytic Anemia
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Symptoms & Phenotypes for Microcytic Anemia

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MGI Mouse Phenotypes related to Microcytic Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 IREB2 TMPRSS6 PSMB8 SLC11A2 ST14 ALAS2
2 homeostasis/metabolism MP:0005376 10.06 TFRC IREB2 TMPRSS6 SLC11A2 ACO1 ST14
3 immune system MP:0005387 9.86 EPO TFRC IREB2 PSMB8 TMPRSS6 SLC11A2
4 integument MP:0010771 9.7 TFRC IREB2 TMPRSS6 SLC11A2 ST14 ALAS2
5 liver/biliary system MP:0005370 9.43 TFRC IREB2 TMPRSS6 SLC11A2 STEAP3 EPO
6 mortality/aging MP:0010768 9.36 HBA2 TFRC IREB2 TMPRSS6 SLC11A2 ACO1
Sources

Drugs & Therapeutics for Microcytic Anemia

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Drugs for Microcytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2,Not Applicable 7439-89-6 23925
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
3 Anticoagulants Phase 2
4 Calcium, Dietary Phase 2
5 Chelating Agents Phase 2
6 Micronutrients Phase 2,Not Applicable
7 Pharmaceutical Solutions Phase 2
8 Trace Elements Phase 2,Not Applicable
9 Citrate Nutraceutical Phase 2
10 Iron Supplement Nutraceutical Phase 2,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Triferic IRIDA Protocol Completed NCT02905981 Phase 2 Fer-In-Sol;Shohl's solution;Triferic
2 Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic Counter Enrolling by invitation NCT00481221
3 The Effect of Genetic Variation in TMPRSS6 Gene (SNP rs855791) on Oral Iron Absorption: an Iron Stable Isotope Study Not yet recruiting NCT03317873 Not Applicable

Search NIH Clinical Center for Microcytic Anemia

Cochrane evidence based reviews: iron-refractory iron deficiency anemia

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Genetic Tests for Microcytic Anemia

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Genetic tests related to Microcytic Anemia:

# Genetic test Affiliating Genes
1 Microcytic Anemia 29 TMPRSS6
Sources

Anatomical Context for Microcytic Anemia

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MalaCards organs/tissues related to Microcytic Anemia:

41
Liver, Bone Marrow, Bone, Skin, Colon, Kidney
Sources

Publications for Microcytic Anemia

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Articles related to Microcytic Anemia:

(show top 50) (show all 136)
# Title Authors Year
1
Identification of iron status of blood donors by using low hemoglobin density and microcytic anemia factor. ( 29563675 )
2018
2
Hereditary hypochromic microcytic anemia associated with loss-of-function DMT1 gene mutations and absence of liver iron overload. ( 29178181 )
2018
3
Microcytic anemia due to ileocolic anastomotic ulcer. ( 29588085 )
2018
4
Glycogen storage disease type Ia: Adult presentation with microcytic anemia and liver adenomas. ( 29486517 )
2018
5
Critical appraisal of discriminant formulas for distinguishing thalassemia from iron deficiency in patients with microcytic anemia. ( 28182576 )
2017
6
Gastrointestinal: Cause or effect: A case of microcytic anemia. ( 29024014 )
2017
7
Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation. ( 27662012 )
2016
8
Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a reply. ( 26812799 )
2016
9
Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia. ( 26812794 )
2016
10
Mild Microcytic Anemia in an Infant with a Compound Heterozygosity for Hb C (HBB: c.19Ga88>a88A) and Hb Osu Christiansborg (HBB: c.157Ga88>a88A). ( 27117572 )
2016
11
Extent of Microcytic Anemia among Children in a low-income, Peri-urban Community in the Dominican Republic using different cut-points. ( 25505156 )
2015
12
Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model. ( 25515317 )
2015
13
Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The A^stanbul Perspective. ( 26377141 )
2015
14
Clinical Reasoning: A 28-year-old woman with lower extremity spasticity and microcytic anemia. ( 26170404 )
2015
15
Discrimination index of microcytic anemia in young soldiers: a single institutional analysis. ( 25679510 )
2015
16
Application of Innovative Hemocytometric Parameters and Algorithms for Improvement of Microcytic Anemia Discrimination. ( 26331001 )
2015
17
Prevalence of alpha thalassemia in microcytic anemia: a tertiary care experience from north India. ( 25574363 )
2015
18
Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a meta-analysis. ( 26536581 )
2015
19
Further acatalasemia mutations in human patients from Hungary with diabetes and microcytic anemia. ( 25772105 )
2015
20
A double red cells population in a woman with a microcytic anemia. ( 24660232 )
2014
21
Sixteen years post radiotherapy of nasopharyngeal carcinoma elicited multi-dysfunction along PTX and chronic kidney disease with microcytic anemia. ( 24520983 )
2014
22
Microcytic anemia. ( 25539121 )
2014
23
Differential diagnosis of microcytic anemia: the role of microcytic and hypochromic erythrocytes. ( 25181647 )
2014
24
Exacerbation of microcytic anemia associated with cessation of anti-retroviral therapy in an HIV-1-infected patient with beta thalassemia. ( 24613601 )
2014
25
Microcytic anemia. ( 25271605 )
2014
26
Meckel's diverticulum revealed by microcytic anemia: the contribution of CT enteroclysis. ( 24618562 )
2014
27
Microcytic anemia. ( 25539122 )
2014
28
Microcytic anemia. ( 25539120 )
2014
29
Enhanced accuracy of optical platelet counts in microcytic anemia. ( 24719982 )
2014
30
Microcytic anemia in a pregnant woman: beyond iron deficiency. ( 25547425 )
2014
31
Microcytic anemia. ( 25539123 )
2014
32
Early detection of iron deficiency in elite athletes: could microcytic anemia factor (Maf) be useful? ( 23731862 )
2013
33
p,p'-DDT induces microcytic anemia in rats. ( 24067725 )
2013
34
Iron-Refractory Microcytic Anemia as the Presenting Feature of Unicentric Castleman Disease in Children. ( 24367988 )
2013
35
Multivariable discriminant analysis for the differential diagnosis of microcytic anemia. ( 24093062 )
2013
36
Castleman-Kojima disease (TAFRO syndrome) : a novel systemic inflammatory disease characterized by a constellation of symptoms, namely, thrombocytopenia, ascites (anasarca), microcytic anemia, myelofibrosis, renal dysfunction, and organomegaly : a status report and summary of Fukushima (6 June, 2012) and Nagoya meetings (22 September, 2012). ( 23801135 )
2013
37
Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6. ( 22244935 )
2012
38
An unusual case of severe microcytic anemia. ( 22031122 )
2012
39
A simple method for examination of polymorphisms of catalase exon 9: rs769217 in Hungarian microcytic anemia and beta-thalassemia patients. ( 22286031 )
2012
40
I+-Thalassemia frequency and mutations in children with hypochromic microcytic anemias and relation with I^-thalassemia, iron deficiency anemia. ( 22475300 )
2012
41
A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload. ( 21871825 )
2011
42
The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and I^-thalassemia screening. ( 21350090 )
2011
43
Surgically curable non-iron deficiency microcytic anemia: Castleman's disease. ( 21934347 )
2011
44
The role of automated measurement of red cell subpopulations on the Sysmex XE 5000 analyzer in the differential diagnosis of microcytic anemia. ( 20492000 )
2011
45
An autosomal recessive syndrome of joint contractures, muscular atrophy, microcytic anemia, and panniculitis-associated lipodystrophy. ( 20534754 )
2010
46
PSMB8 encoding the beta5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis- induced lipodystrophy syndrome. ( 21129723 )
2010
47
Prevalence of common I+-thalassemia determinants in south Brazil: Importance for the diagnosis of microcytic anemia. ( 21637571 )
2010
48
Stiff-person syndrome in a female patient with type 1 diabetes, dermatitis herpetiformis, celiac disease, microcytic anemia and copper deficiency Just a coincidence or an additional shared pathophysiological mechanism? ( 19473752 )
2009
49
Evaluation of microcytic anemia. ( 18832550 )
2009
50
Hypochromic microcytic anemia with a variant hemoglobin. ( 19006231 )
2009
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Variations for Microcytic Anemia

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ClinVar genetic disease variations for Microcytic Anemia:

6
(show top 50) (show all 128)
# Gene Variation Type Significance SNP ID Assembly Location
1 TMPRSS6 NM_153609.3(TMPRSS6): c.1904_1905dupGC (p.Lys636Alafs) duplication Pathogenic rs869320724 GRCh38 Chromosome 22, 37069308: 37069309
2 TMPRSS6 NM_153609.3(TMPRSS6): c.1904_1905dupGC (p.Lys636Alafs) duplication Pathogenic rs869320724 GRCh37 Chromosome 22, 37465348: 37465349
3 TMPRSS6 NM_153609.3(TMPRSS6): c.1813delG (p.Ala605Profs) deletion Pathogenic rs786205057 GRCh37 Chromosome 22, 37466579: 37466579
4 TMPRSS6 NM_153609.3(TMPRSS6): c.1813delG (p.Ala605Profs) deletion Pathogenic rs786205057 GRCh38 Chromosome 22, 37070539: 37070539
5 TMPRSS6 NM_153609.3(TMPRSS6): c.1582+1G> A single nucleotide variant Pathogenic rs786205058 GRCh37 Chromosome 22, 37469571: 37469571
6 TMPRSS6 NM_153609.3(TMPRSS6): c.1582+1G> A single nucleotide variant Pathogenic rs786205058 GRCh38 Chromosome 22, 37073531: 37073531
7 TMPRSS6 NM_153609.3(TMPRSS6): c.2140+1G> C single nucleotide variant Pathogenic rs786205059 GRCh37 Chromosome 22, 37465112: 37465112
8 TMPRSS6 NM_153609.3(TMPRSS6): c.2140+1G> C single nucleotide variant Pathogenic rs786205059 GRCh38 Chromosome 22, 37069072: 37069072
9 TMPRSS6 NM_153609.3(TMPRSS6): c.1324G> A (p.Gly442Arg) single nucleotide variant Pathogenic rs137853119 GRCh37 Chromosome 22, 37471220: 37471220
10 TMPRSS6 NM_153609.3(TMPRSS6): c.1324G> A (p.Gly442Arg) single nucleotide variant Pathogenic rs137853119 GRCh38 Chromosome 22, 37075180: 37075180
11 TMPRSS6 NM_153609.3(TMPRSS6): c.1561G> A (p.Asp521Asn) single nucleotide variant Pathogenic rs137853120 GRCh37 Chromosome 22, 37469593: 37469593
12 TMPRSS6 NM_153609.3(TMPRSS6): c.1561G> A (p.Asp521Asn) single nucleotide variant Pathogenic rs137853120 GRCh38 Chromosome 22, 37073553: 37073553
13 TMPRSS6 NM_153609.3(TMPRSS6): c.1065C> A (p.Tyr355Ter) single nucleotide variant Pathogenic rs137853121 GRCh37 Chromosome 22, 37480815: 37480815
14 TMPRSS6 NM_153609.3(TMPRSS6): c.1065C> A (p.Tyr355Ter) single nucleotide variant Pathogenic rs137853121 GRCh38 Chromosome 22, 37084775: 37084775
15 TMPRSS6 TMPRSS6, 1-BP DEL, 1383A deletion Pathogenic
16 TMPRSS6 NM_153609.3(TMPRSS6): c.1179T> G (p.Tyr393Ter) single nucleotide variant Pathogenic rs137853122 GRCh37 Chromosome 22, 37480379: 37480379
17 TMPRSS6 NM_153609.3(TMPRSS6): c.1179T> G (p.Tyr393Ter) single nucleotide variant Pathogenic rs137853122 GRCh38 Chromosome 22, 37084339: 37084339
18 TMPRSS6 NM_153609.3(TMPRSS6): c.1795C> T (p.Arg599Ter) single nucleotide variant Pathogenic rs137853123 GRCh37 Chromosome 22, 37466597: 37466597
19 TMPRSS6 NM_153609.3(TMPRSS6): c.1795C> T (p.Arg599Ter) single nucleotide variant Pathogenic rs137853123 GRCh38 Chromosome 22, 37070557: 37070557
20 TMPRSS6 NM_153609.3(TMPRSS6): c.2055_2058dupCCCC (p.Val687Profs) duplication Pathogenic rs786205060 GRCh37 Chromosome 22, 37465195: 37465198
21 TMPRSS6 NM_153609.3(TMPRSS6): c.2055_2058dupCCCC (p.Val687Profs) duplication Pathogenic rs786205060 GRCh38 Chromosome 22, 37069155: 37069158
22 TMPRSS6 NM_153609.3(TMPRSS6): c.353C> A (p.Ala118Asp) single nucleotide variant Pathogenic rs267607121 GRCh37 Chromosome 22, 37494466: 37494466
23 TMPRSS6 NM_153609.3(TMPRSS6): c.353C> A (p.Ala118Asp) single nucleotide variant Pathogenic rs267607121 GRCh38 Chromosome 22, 37098426: 37098426
24 TMPRSS6 NM_153609.3(TMPRSS6): c.1564G> A (p.Glu522Lys) single nucleotide variant Pathogenic rs387907018 GRCh37 Chromosome 22, 37469590: 37469590
25 TMPRSS6 NM_153609.3(TMPRSS6): c.1564G> A (p.Glu522Lys) single nucleotide variant Pathogenic rs387907018 GRCh38 Chromosome 22, 37073550: 37073550
26 TMPRSS6 NM_153609.3(TMPRSS6): c.1336C> T (p.Arg446Trp) single nucleotide variant Benign/Likely benign rs117576908 GRCh37 Chromosome 22, 37471208: 37471208
27 TMPRSS6 NM_153609.3(TMPRSS6): c.1336C> T (p.Arg446Trp) single nucleotide variant Benign/Likely benign rs117576908 GRCh38 Chromosome 22, 37075168: 37075168
28 TMPRSS6 NM_153609.3(TMPRSS6): c.2217C> T (p.Tyr739=) single nucleotide variant Benign rs2235321 GRCh37 Chromosome 22, 37462926: 37462926
29 TMPRSS6 NM_153609.3(TMPRSS6): c.2217C> T (p.Tyr739=) single nucleotide variant Benign rs2235321 GRCh38 Chromosome 22, 37066886: 37066886
30 TMPRSS6 NM_153609.3(TMPRSS6): c.2207T> C (p.Val736Ala) single nucleotide variant Benign rs855791 GRCh37 Chromosome 22, 37462936: 37462936
31 TMPRSS6 NM_153609.3(TMPRSS6): c.2207T> C (p.Val736Ala) single nucleotide variant Benign rs855791 GRCh38 Chromosome 22, 37066896: 37066896
32 TMPRSS6 NM_153609.3(TMPRSS6): c.1869-6_1869-2delCCCCA deletion Benign rs200434923 GRCh37 Chromosome 22, 37465386: 37465390
33 TMPRSS6 NM_153609.3(TMPRSS6): c.1869-6_1869-2delCCCCA deletion Benign rs200434923 GRCh38 Chromosome 22, 37069346: 37069350
34 TMPRSS6 NM_153609.3(TMPRSS6): c.1563C> T (p.Asp521=) single nucleotide variant Benign rs4820268 GRCh37 Chromosome 22, 37469591: 37469591
35 TMPRSS6 NM_153609.3(TMPRSS6): c.1563C> T (p.Asp521=) single nucleotide variant Benign rs4820268 GRCh38 Chromosome 22, 37073551: 37073551
36 TMPRSS6 NM_153609.3(TMPRSS6): c.1468+10C> T single nucleotide variant Uncertain significance rs79816125 GRCh38 Chromosome 22, 37074600: 37074600
37 TMPRSS6 NM_153609.3(TMPRSS6): c.1468+10C> T single nucleotide variant Uncertain significance rs79816125 GRCh37 Chromosome 22, 37470640: 37470640
38 TMPRSS6 NM_153609.3(TMPRSS6): c.1254C> T (p.Tyr418=) single nucleotide variant Likely benign rs881144 GRCh38 Chromosome 22, 37075250: 37075250
39 TMPRSS6 NM_153609.3(TMPRSS6): c.1254C> T (p.Tyr418=) single nucleotide variant Likely benign rs881144 GRCh37 Chromosome 22, 37471290: 37471290
40 TMPRSS6 NM_153609.3(TMPRSS6): c.1083G> A (p.Ser361=) single nucleotide variant Benign rs2111833 GRCh37 Chromosome 22, 37480797: 37480797
41 TMPRSS6 NM_153609.3(TMPRSS6): c.1083G> A (p.Ser361=) single nucleotide variant Benign rs2111833 GRCh38 Chromosome 22, 37084757: 37084757
42 TMPRSS6 NM_153609.3(TMPRSS6): c.757A> G (p.Lys253Glu) single nucleotide variant Benign rs2235324 GRCh37 Chromosome 22, 37485724: 37485724
43 TMPRSS6 NM_153609.3(TMPRSS6): c.757A> G (p.Lys253Glu) single nucleotide variant Benign rs2235324 GRCh38 Chromosome 22, 37089684: 37089684
44 TMPRSS6 NM_153609.3(TMPRSS6): c.99G> A (p.Pro33=) single nucleotide variant Likely benign rs11704654 GRCh37 Chromosome 22, 37499386: 37499386
45 TMPRSS6 NM_153609.3(TMPRSS6): c.99G> A (p.Pro33=) single nucleotide variant Likely benign rs11704654 GRCh38 Chromosome 22, 37103346: 37103346
46 TMPRSS6 NM_153609.3(TMPRSS6): c.15C> T (p.Phe5=) single nucleotide variant Uncertain significance rs115270691 GRCh38 Chromosome 22, 37103525: 37103525
47 TMPRSS6 NM_153609.3(TMPRSS6): c.15C> T (p.Phe5=) single nucleotide variant Uncertain significance rs115270691 GRCh37 Chromosome 22, 37499565: 37499565
48 TMPRSS6 NM_153609.3(TMPRSS6): c.*503C> G single nucleotide variant Uncertain significance rs117575523 GRCh38 Chromosome 22, 37065577: 37065577
49 TMPRSS6 NM_153609.3(TMPRSS6): c.*503C> G single nucleotide variant Uncertain significance rs117575523 GRCh37 Chromosome 22, 37461617: 37461617
50 TMPRSS6 NM_153609.3(TMPRSS6): c.*499C> T single nucleotide variant Uncertain significance rs560949530 GRCh38 Chromosome 22, 37065581: 37065581
Sources

Expression for Microcytic Anemia

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Search GEO for disease gene expression data for Microcytic Anemia.
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Pathways for Microcytic Anemia

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Pathways related to Microcytic Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
12.11 ACO1 CAT IREB2 SLC11A2
2
Insulin receptor recycling 66
Show member pathways
 12 SLC11A2 STEAP3 TF TFRC
3
HIF-1 signaling pathway 37
11.54 EPO TF TFRC
4
HIF-1-alpha transcription factor network 1
11.14 EPO TF TFRC
5
African trypanosomiasis 37
11.02 HBA1 HBA2
6
O2/CO2 exchange in erythrocytes 66
Show member pathways
 11 HBA1 HBA2
7
HIF-2-alpha transcription factor network 1
10.96 EPO SLC11A2
8
Ferroptosis 37
10.86 SLC11A2 STEAP3 TF TFRC
9
Glyoxylate and dicarboxylate metabolism 37
10.85 ACO1 CAT
10
Iron metabolism in placenta 1
10.18 ACO1 IREB2 SLC11A2 STEAP3 TF TFRC
Sources

GO Terms for Microcytic Anemia

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Cellular components related to Microcytic Anemia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 9.63 SLC11A2 TF TFRC
2 endosome membrane GO:0010008 9.56 SLC11A2 STEAP3 TF TFRC
3 blood microparticle GO:0072562 9.46 HBA1 HBA2 TF TFRC
4 endocytic vesicle lumen GO:0071682 9.43 HBA1 HBA2
5 hemoglobin complex GO:0005833 9.4 HBA1 HBA2
6 basal part of cell GO:0045178 9.37 SLC11A2 TF
7 HFE-transferrin receptor complex GO:1990712 9.32 TF TFRC
8 extracellular space GO:0005615 9.23 CAT EPO HBA1 HBA2 ST14 TF
9 haptoglobin-hemoglobin complex GO:0031838 8.96 HBA1 HBA2
10 extracellular exosome GO:0070062 10.08 ACO1 CAT HBA1 HBA2 PSMB8 ST14
11 extracellular region GO:0005576 10.04 CAT EPO HBA1 HBA2 ST14 TF

Biological processes related to Microcytic Anemia according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.76 HBA1 HBA2 TFRC
2 response to hypoxia GO:0001666 9.74 ALAS2 CAT EPO
3 cellular oxidant detoxification GO:0098869 9.63 CAT HBA1 HBA2
4 osteoclast differentiation GO:0030316 9.58 IREB2 TFRC
5 response to vitamin A GO:0033189 9.56 CAT EPO
6 heme biosynthetic process GO:0006783 9.55 ALAS2 SLC11A2
7 oxygen transport GO:0015671 9.54 HBA1 HBA2
8 response to hydrogen peroxide GO:0042542 9.54 CAT HBA1 HBA2
9 intestinal absorption GO:0050892 9.52 ACO1 IREB2
10 response to hyperoxia GO:0055093 9.51 CAT EPO
11 transferrin transport GO:0033572 9.5 STEAP3 TF TFRC
12 plasminogen activation GO:0031639 9.49 ST14 TMPRSS6
13 protoporphyrinogen IX biosynthetic process GO:0006782 9.48 ALAS2 IREB2
14 hemoglobin biosynthetic process GO:0042541 9.43 ALAS2 EPO
15 hydrogen peroxide catabolic process GO:0042744 9.43 CAT HBA1 HBA2
16 porphyrin-containing compound metabolic process GO:0006778 9.4 ALAS2 SLC11A2
17 iron ion homeostasis GO:0055072 9.35 IREB2 SLC11A2 STEAP3 TF TMPRSS6
18 iron ion transport GO:0006826 9.33 IREB2 SLC11A2 TF
19 cellular iron ion homeostasis GO:0006879 9.17 ACO1 ALAS2 IREB2 SLC11A2 TF TFRC

Molecular functions related to Microcytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.54 CAT HBA1 HBA2
2 oxygen carrier activity GO:0005344 9.32 HBA1 HBA2
3 haptoglobin binding GO:0031720 9.16 HBA1 HBA2
4 iron-responsive element binding GO:0030350 8.96 ACO1 IREB2
5 peroxidase activity GO:0004601 8.8 CAT HBA1 HBA2
6 protein binding GO:0005515 10.1 ACO1 ALAS2 CAT EPO HBA1 HBA2
Sources

Sources for Microcytic Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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