MCID: MCR374
MIFTS: 22

Microencephaly

Categories: Rare diseases

Aliases & Classifications for Microencephaly

MalaCards integrated aliases for Microencephaly:

Name: Microencephaly 54

Classifications:



Summaries for Microencephaly

MalaCards based summary : Microencephaly is related to pontocerebellar hypoplasia, type 5 and pontocerebellar hypoplasia, type 6. An important gene associated with Microencephaly is WDR62 (WD Repeat Domain 62). The drugs Magnesium Sulfate and Calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and liver.

Wikipedia : 77 Microcephaly is a medical condition in which the brain does not develop properly resulting in a smaller... more...

Related Diseases for Microencephaly

Diseases related to Microencephaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 pontocerebellar hypoplasia, type 5 11.3
2 pontocerebellar hypoplasia, type 6 11.3
3 duker weiss siber syndrome 11.2
4 cerebellar agenesis 11.1
5 microphthalmia 10.2
6 tuberous sclerosis 1 10.0
7 cryptorchidism, unilateral or bilateral 10.0
8 hydrocephalus 10.0
9 liver disease 10.0
10 lissencephaly 10.0
11 hypospadias 10.0
12 tuberous sclerosis 10.0

Graphical network of the top 20 diseases related to Microencephaly:



Diseases related to Microencephaly

Symptoms & Phenotypes for Microencephaly

Drugs & Therapeutics for Microencephaly

Drugs for Microencephaly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
2
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
3 Anticonvulsants Phase 3
4 Central Nervous System Depressants Phase 3
5 Tocolytic Agents Phase 3
6 Calcium, Dietary Phase 3
7 Anesthetics Phase 3
8 Analgesics Phase 3
9 Anti-Arrhythmia Agents Phase 3
10 Hormones Phase 3
11 calcium channel blockers Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Antibodies Phase 3,Not Applicable
14 Immunoglobulins, Intravenous Phase 3
15 Rho(D) Immune Globulin Phase 3
16 gamma-Globulins Phase 3
17 Immunoglobulins Phase 3,Not Applicable
18 Immunoglobulin G Phase 3
19
Vidarabine Approved, Investigational Phase 2 24356-66-9 21704 32326
20
Mycophenolic acid Approved Phase 2 24280-93-1 446541
21
alemtuzumab Approved, Investigational Phase 2,Phase 1 216503-57-0
22
Fludarabine Approved Phase 2,Phase 1 75607-67-9, 21679-14-1 30751
23
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
24
Ambrisentan Approved, Investigational Phase 2 177036-94-1 6918493
25 Antimetabolites Phase 2,Phase 1,Not Applicable
26 Immunologic Factors Phase 2,Phase 1
27 Dermatologic Agents Phase 2
28 Cyclosporins Phase 2
29 Antibiotics, Antitubercular Phase 2
30 Anti-Infective Agents Phase 2
31 Antimetabolites, Antineoplastic Phase 2,Phase 1
32 Alkylating Agents Phase 2
33 Antitubercular Agents Phase 2
34 Calcineurin Inhibitors Phase 2
35 Immunosuppressive Agents Phase 2,Phase 1
36 Antirheumatic Agents Phase 2
37 Antiviral Agents Phase 2
38 Antifungal Agents Phase 2
39 Anti-Bacterial Agents Phase 2
40 Antineoplastic Agents, Immunological Phase 2,Phase 1
41 Antihypertensive Agents Phase 2
42 Vaccines Phase 1,Not Applicable
43
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
44
Methylcobalamin Approved, Experimental, Investigational Not Applicable 13422-55-4
45 Vedolizumab Approved 943609-66-3
46
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
47
Creatine Approved, Investigational, Nutraceutical Not Applicable 57-00-1 586
48
Betaine Approved, Nutraceutical Not Applicable 107-43-7 247
49
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
50
Cobalamin Experimental Not Applicable 13408-78-1 6857388

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
2 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Active, not recruiting NCT01376778 Phase 3 CMV hyperimmune globulin
3 Transfusion of Prematures Trial Active, not recruiting NCT01702805 Phase 3
4 Whole Body Cooling Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
5 Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita Recruiting NCT01659606 Phase 2 Fludarabine;Cyclosporins;Mycophenolate mofetil
6 Ambrisentan in Single Ventricle Active, not recruiting NCT02080637 Phase 2 Ambrisentan
7 Study of GLS-5700 in Dengue Virus Seropositive Adults Completed NCT02887482 Phase 1
8 Study of GLS-5700 in Healthy Volunteers Completed NCT02809443 Phase 1
9 Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA085-00-VP, in Healthy Adults Completed NCT02840487 Phase 1
10 Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT Terminated NCT00586274 Phase 1 Fludarabine
11 Zika Virus Infection's Pregnancy Consequences in French Department of America Unknown status NCT02916732
12 Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases Unknown status NCT02340871
13 Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Unknown status NCT02810210
14 Microcephaly Genetic Deficiency in Neural Progenitors Completed NCT01565005
15 Zika and Microcephaly: Case-control Study Completed NCT02741882
16 The Primordial Dwarfisms: Diagnosis, Identification of the Molecular Basis of Seckel Syndrome and Microcephalic Osteodysplastic Primordial Dwarfism Type II Completed NCT03139903
17 Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome Completed NCT03330600 Not Applicable
18 Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection Completed NCT03679728
19 Fetal and Maternal Head Circumference During Pregnancy in Israeli Population Completed NCT02510170
20 Evaluation of Patients With Unresolved Chromosome Abnormalities Completed NCT00001639
21 Bone Mineral Density in Adults With Hyperphenylalaninemia Completed NCT01209819
22 Dietary Supplements for the Treatment of Angelman Syndrome Completed NCT00348933 Not Applicable Betaine;Creatine;Metafolin;Vitamin B12
23 TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia Completed NCT00147030 Not Applicable
24 CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy Completed NCT00383305 Not Applicable
25 Clinical, Molecular and Physiopathological Study of Cohen Syndrome and Cohen-like Syndromes Completed NCT01907555
26 Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM) Recruiting NCT03651687
27 Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Recruiting NCT03255369
28 Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Recruiting NCT02943304
29 The VTCRI Neuromotor Research Clinic Recruiting NCT03325946
30 The Safety Assessment of Vedolizumab During Pregnancy in IBD Patient Recruiting NCT02617927
31 Metabolic Study of Cockayne Syndrome Recruiting NCT03044210 Not Applicable
32 Relevance of Gastric Aspirate in HCMV Detection Recruiting NCT03262194
33 Immunological Characteristics of Maternal-fetal Transmission of Cytomegalovirus in Pregnancy Recruiting NCT02129465
34 Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies Recruiting NCT03056794
35 North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 Recruiting NCT03548779 Not Applicable
36 Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women Recruiting NCT01310023
37 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
38 Zika in Infants and Pregnancy (ZIP) Active, not recruiting NCT02856984
39 Hypothermia for Encephalopathy in Low and Middle-Income Countries Trial Active, not recruiting NCT02387385 Not Applicable
40 Surveillance of Zika-related Microcephaly in Sub-Saharan Africa and Asia Not yet recruiting NCT03922594
41 New Variants Involved in Taybi-Linder Syndrome Not yet recruiting NCT03222947
42 A Study of Outcomes and Events of Interest in Pregnant Women, Neonates and Infants and of RSV Surveillance Not yet recruiting NCT03614676 Not Applicable
43 Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes. Withdrawn NCT01151462

Search NIH Clinical Center for Microencephaly

Genetic Tests for Microencephaly

Anatomical Context for Microencephaly

MalaCards organs/tissues related to Microencephaly:

42
Brain, Bone, Liver, Bone Marrow, Cortex, Heart, Cerebellum

Publications for Microencephaly

Articles related to Microencephaly:

(show all 44)
# Title Authors Year
1
Microencephaly in fetal piglets following in utero inoculation of Zika virus. ( 29593256 )
2018
2
Zika virus as a causative agent for primary microencephaly: the evidence so far. ( 27412681 )
2016
3
Genetic absence of nNOS worsens fetal alcohol effects in mice. II: microencephaly and neuronal losses. ( 25664654 )
2015
4
An autopsy case of microencephaly, bizarre putaminal lesion, and cerebellar atrophy with heart and liver diseases. ( 24491944 )
2014
5
Lissencephaly and microencephaly combined with hypoplasia of corpus callosum and cerebellum in a domestic cat. ( 22143590 )
2011
6
Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. ( 21592121 )
2011
7
A single exposure to alcohol during brain development induces microencephaly and neuronal losses in genetically susceptible mice, but not in wild type mice. ( 19442832 )
2009
8
Peritoneal dialysis in microencephaly. ( 19260611 )
2008
9
Infantile spasm-associated microencephaly in tuberous sclerosis complex and cortical dysplasia. ( 17283320 )
2007
10
Microencephaly and microphthalmia in rat fetuses by busulfan. ( 17290349 )
2007
11
Indole-3-acetic acid induces microencephaly in mouse fetuses. ( 17583487 )
2007
12
Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly. ( 16870734 )
2006
13
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. ( 16971543 )
2006
14
Ascorbic acid inhibits ROS production, NF-kappa B activation and prevents ethanol-induced growth retardation and microencephaly. ( 15721175 )
2005
15
Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain. ( 16022871 )
2005
16
Indole-3-acetic acid induces microencephaly in rat fetuses. ( 15513909 )
2004
17
Experimentally-induced microencephaly: effects on cortical neurons. ( 12781321 )
2003
18
Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. ( 12234657 )
2002
19
Kinetic assessment of the effects of task difficulty, microencephaly, and a response manipulandum alteration on the rate of fixed-ratio discrimination acquisition. ( 12498338 )
2002
20
Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. ( 10818151 )
2000
21
Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly. ( 9518677 )
1998
22
Microencephaly in children congenitally infected with human immunodeficiency virus--a gross-anatomical morphometric study. ( 9039460 )
1997
23
Microencephaly and selective decreases in cerebellar Purkinje cell numbers following combined exposure to ethanol and methadone during rat brain development. ( 9323464 )
1997
24
Fetal alcohol exposure and temporal vulnerability regional differences in alcohol-induced microencephaly as a function of the timing of binge-like alcohol exposure during rat brain development. ( 9394113 )
1997
25
4-Methylpyrazole, an alcohol dehydrogenase inhibitor, exacerbates alcohol-induced microencephaly during the brain growth spurt. ( 7546332 )
1995
26
Long-lasting microencephaly following exposure to cocaine during the brain growth spurt in the rat. ( 7743636 )
1995
27
Alcohol-induced brain growth restrictions (microencephaly) were not affected by concurrent exposure to cocaine during the brain growth spurt. ( 7871489 )
1994
28
Protein kinase C-dependent phosphorylation in prenatally induced microencephaly. ( 8090355 )
1994
29
Excitatory amino acid receptors in brains of rats with methylazoxymethanol-induced microencephaly. ( 1324453 )
1992
30
Cellular expression of somatostatin in MAM-induced microencephaly in the rat. ( 1361885 )
1992
31
Microencephaly reduces the phosphorylation of the PKC substrate B-50/GAP43 in rat cortex and hippocampus. ( 1826859 )
1991
32
Patterns of transiently expressed acetylcholinesterase activity in cerebral cortex and dorsal thalamus of developing rats with cytotoxin-induced microencephaly. ( 2327291 )
1990
33
Methylazoxymethanol-induced microencephaly: persistent increase of cortical somatostatin-like immunoreactivity. ( 2736763 )
1989
34
Blood alcohol concentration and microencephaly: a dose-response study in the neonatal rat. ( 3368876 )
1988
35
Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration. ( 3415765 )
1988
36
Microencephaly and hyperactivity in adult rats can be induced by neonatal exposure to high blood alcohol concentrations. ( 3582546 )
1987
37
Alcohol-induced microencephaly during the third trimester equivalent: relationship to dose and blood alcohol concentration. ( 3741615 )
1986
38
X-linked recessive microencephaly, microphthalmia with corneal opacities, spastic quadriplesia, hypospadias and cryptorchidism. ( 6149829 )
1984
39
Methylazoxymethanol microencephaly in rats: neurochemical characterization and behavioral studies with the nootropic oxiracetam. ( 6701181 )
1984
40
Fatal CNS dysgenesis with severe microencephaly, mental retardation, seizures and paucity of myelin, autosomal recessive trait? ( 837946 )
1977
41
Histochemical investigation of experimental microencephaly induced by methylazoxymethanol acetate (MAMA). ( 840387 )
1977
42
Transplacental chemical induction of microencephaly in two strains of rats. I. ( 5701472 )
1968
43
External hydrocephalus associated with microencephaly and absence of corpus callosum. ( 13278876 )
1955
44
Medium grade microencephaly in a Bantu family. ( 13076634 )
1953

Variations for Microencephaly

Expression for Microencephaly

Search GEO for disease gene expression data for Microencephaly.

Pathways for Microencephaly

GO Terms for Microencephaly

Sources for Microencephaly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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