MCID: MCR019
MIFTS: 44

Microglandular Adenosis

Aliases & Classifications for Microglandular Adenosis

MalaCards integrated aliases for Microglandular Adenosis:

Name: Microglandular Adenosis 12 15
Fibrocystic Breast Disease 44
Breast Fibrocystic Disease 73
Adenosis of the Breast 12
Adenosis of Breast 73
Adenosis - Breast 12

External Ids:

Disease Ontology 12 DOID:5998
MeSH 44 D005348
NCIt 50 C3484

Summaries for Microglandular Adenosis

Disease Ontology : 12 A breast disease that is characterized by a haphazard infiltration of small, uniformly open, and round glands which are lined by a monolayer of flat to cuboidal epithelial cells that lack a myoepithelial layer, the absence of stromal desmoplasia and the presence of a thickened basement membrane.

MalaCards based summary : Microglandular Adenosis, also known as fibrocystic breast disease, is related to breast disease and tubular adenocarcinoma. An important gene associated with Microglandular Adenosis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Development EGFR signaling pathway. The drugs Immunologic Factors and Autoantibodies have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and thyroid, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Microglandular Adenosis

Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 breast disease 31.2 ERBB2 PGR TP53
2 tubular adenocarcinoma 30.5 ERBB2 PGR
3 adenocarcinoma 30.2 EGFR ERBB2 TP53
4 breast fibroadenoma 30.0 ERBB2 PGR
5 adenoid cystic carcinoma 30.0 ERBB2 PGR S100B TP53
6 breast cancer 29.4 EGFR ERBB2 KRT18 PGR PIP TP53
7 microglandular adenosis of breast 12.3
8 apocrine adenosis of breast 11.6
9 fibrosclerosis of breast 11.3
10 breast adenomyoepithelial adenosis 11.1
11 sclerosing adenosis of breast 11.1
12 sinusitis 10.4
13 adenoma 10.2
14 scirrhous adenocarcinoma 10.2 ERBB2 PGR
15 breast apocrine carcinoma 10.2 ERBB2 PGR
16 glassy cell carcinoma of the cervix 10.2 ERBB2 PGR
17 intracystic papillary adenoma 10.2 ERBB2 PGR
18 breast metaplastic carcinoma 10.2 ERBB2 PGR
19 breast medullary carcinoma 10.2 ERBB2 PGR
20 progesterone-receptor positive breast cancer 10.2 ERBB2 PGR
21 ependymoma 10.2 EGFR S100B
22 breast adenoid cystic carcinoma 10.2 ERBB2 PGR
23 apocrine adenocarcinoma 10.2 ERBB2 PGR
24 breast cyst 10.1
25 breast secretory carcinoma 10.1 ERBB2 PGR
26 breast intraductal proliferative lesion 10.1 EGFR ERBB2
27 breast neuroendocrine neoplasm 10.1 ERBB2 PIP
28 gastric signet ring cell adenocarcinoma 10.1 PGR PIP
29 bilateral breast cancer 10.1 ERBB2 PGR
30 papillary hidradenoma 10.1 PGR PIP
31 meningioma, radiation-induced 10.1 PGR S100B
32 vulval paget's disease 10.1 ERBB2 PIP
33 malignant giant cell tumor 10.1 S100B TP53
34 endometrium carcinoma in situ 10.1 PGR TP53
35 vulva adenocarcinoma 10.1 ERBB2 PIP
36 bladder disease 10.1 ERBB2 TP53
37 chordoid glioma 10.1 S100B TP53
38 spiradenoma 10.1 S100B TP53
39 paget disease, extramammary 10.1 ERBB2 PIP
40 spinal chordoma 10.1 EGFR S100B
41 breast malignant phyllodes tumor 10.1 PGR TP53
42 acneiform dermatitis 10.1 EGFR ERBB2
43 olfactory groove meningioma 10.1 PGR TP53
44 synchronous bilateral breast carcinoma 10.1 PGR TP53
45 papillary serous adenocarcinoma 10.1 PGR TP53
46 female reproductive endometrioid cancer 10.1 PGR TP53
47 cervical carcinosarcoma 10.1 PGR TP53
48 glycogen-rich clear cell breast carcinoma 10.1 PGR TP53
49 papilloma of choroid plexus 10.1 S100B TP53
50 gastric papillary adenocarcinoma 10.1 ERBB2 TP53

Comorbidity relations with Microglandular Adenosis via Phenotypic Disease Network (PDN):


Breast Fibroadenosis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Hypothyroidism Mastitis

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to Microglandular Adenosis

Symptoms & Phenotypes for Microglandular Adenosis

GenomeRNAi Phenotypes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.13 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 9.13 EGFR
3 Increased cell death HMECs cells GR00103-A-0 9.02 EGFR KRT18 PGR PIP TP53

MGI Mouse Phenotypes related to Microglandular Adenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.8 EGFR ERBB2 KRT18 PGR TP53
2 endocrine/exocrine gland MP:0005379 9.77 EGFR ERBB2 PGR PIP TP53
3 integument MP:0010771 9.72 EGFR ERBB2 PGR S100B TP53
4 limbs/digits/tail MP:0005371 9.56 EGFR ERBB2 PGR TP53
5 neoplasm MP:0002006 9.46 EGFR ERBB2 PGR TP53
6 normal MP:0002873 9.35 EGFR ERBB2 PGR S100B TP53
7 reproductive system MP:0005389 9.02 EGFR ERBB2 PGR PIP TP53

Drugs & Therapeutics for Microglandular Adenosis

Drugs for Microglandular Adenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Autoantibodies
3 Immunoglobulins
4 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test Unknown status NCT02066025

Search NIH Clinical Center for Microglandular Adenosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: fibrocystic breast disease

Genetic Tests for Microglandular Adenosis

Anatomical Context for Microglandular Adenosis

MalaCards organs/tissues related to Microglandular Adenosis:

41
Breast, Bone, Thyroid, Lung, Brain, Colon, Pancreas

Publications for Microglandular Adenosis

Articles related to Microglandular Adenosis:

(show top 50) (show all 85)
# Title Authors Year
1
Microglandular adenosis of the breast: a deceptive and still misterious benign lesion. ( 29949742 )
2018
2
Microglandular Adenosis is an advanced precursor breast lesion with evidence of molecular progression to matrix-producing metaplastic carcinoma. ( 30428388 )
2018
3
Metaplastic Carcinoma With Extensive Chondromyxoid Differentiation Arising in Association With Microglandular Adenosis. ( 28381146 )
2017
4
Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases. ( 28372344 )
2017
5
Metaplastic Carcinoma with Chondroid Differentiation Arising in Microglandular Adenosis. ( 28372347 )
2017
6
Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family. ( 27713419 )
2017
7
Microglandular adenosis: a prime suspect in triple-negative breast cancer development. ( 27061094 )
2016
8
Atypical microglandular adenosis post-neoadjuvant chemotherapy. ( 27773126 )
2016
9
Breast atypical microglandular adenosis can be a diagnostic pitfall on fine-needle aspiration samples. ( 26991047 )
2016
10
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations. ( 26806567 )
2016
11
Vulval Microglandular Adenosis-like Neoplasm With Chondromyxoid Stroma: Report of a Unique Case. ( 26535982 )
2015
12
Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology. ( 25337263 )
2014
13
Acinic cell carcinoma of the breast arising in microglandular adenosis. ( 24369519 )
2013
14
Invasive breast carcinoma arising in microglandular adenosis: two case reports. ( 24454466 )
2013
15
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? ( 23584829 )
2013
16
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. ( 22486256 )
2012
17
Microglandular adenosis with transition to breast carcinoma: a series of three cases. ( 21753716 )
2011
18
Microglandular adenosis. ( 21847399 )
2011
19
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. ( 20846267 )
2010
20
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. ( 20922408 )
2010
21
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. ( 19824997 )
2009
22
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. ( 19922592 )
2009
23
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. ( 19047897 )
2009
24
Breast carcinoma arising in microglandular adenosis: a review of the literature. ( 17824796 )
2007
25
Invasive ductal carcinoma of the breast with a microglandular adenosis pattern. ( 15129910 )
2004
26
Ten-year follow-up of mammary carcinoma arising in microglandular adenosis treated with breast conservation. ( 12521372 )
2003
27
Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. ( 12883237 )
2003
28
Microglandular adenosis of the breast in a BRCA1 mutation carrier: radiological features. ( 12042957 )
2002
29
[Mammary carcinoma arising in microglandular adenosis: a case report]. ( 11852363 )
2001
30
Carcinoma arising in microglandular adenosis of the breast. ( 12574855 )
2001
31
Microglandular adenosis arising in chronic paranasal sinusitis. ( 10841649 )
2000
32
Microglandular adenosis arising in a chronic paranasal sinusitis. ( 11150125 )
2000
33
Carcinoma Arising in Microglandular Adenosis: An Immunohistochemical Analysis of 20 Intraepithelial and Invasive Neoplasms. ( 11494007 )
2000
34
Thyroid hormones in fibrocystic breast disease. ( 7788004 )
1995
35
Carcinoma of the breast arising in microglandular adenosis. ( 7504394 )
1993
36
Immunohistochemical profile and differential diagnosis of microglandular adenosis. ( 8346180 )
1993
37
Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. An immunohistochemical comparison. ( 8422116 )
1993
38
Microglandular adenosis of the breast: fine-needle aspiration biopsy of two cases. ( 8458288 )
1993
39
Histologic changes in fibrocystic breast disease before and after treatment with bromocriptine. ( 1341021 )
1992
40
Microglandular adenosis of the breast. An immunohistochemical comparison with tubular carcinoma. ( 1710101 )
1991
41
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. ( 2101677 )
1990
42
Methylxanthines and fibrocystic breast disease: a study of correlations. ( 2314678 )
1990
43
Bromocriptine treatment of cyclical mastalgia/fibrocystic breast disease: update on the European trial. ( 2488563 )
1989
44
Automated histometry in fibrocystic breast disease. ( 3390284 )
1988
45
Estrogen replacement therapy and fibrocystic breast disease. ( 2838061 )
1987
46
Fibrocystic breast disease. ( 3314435 )
1987
47
Safety of estrogen therapy for women with fibrocystic breast disease. ( 3677568 )
1987
48
Is microglandular adenosis a precancerous disease? A study of carcinoma arising therein. ( 3706610 )
1986
49
Conjugated estrogens and fibrocystic breast disease. ( 3020976 )
1986
50
Current status of hormonal therapy of fibrocystic breast disease. ( 3089096 )
1986

Variations for Microglandular Adenosis

Expression for Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for Microglandular Adenosis

Pathways related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 EGFR ERBB2 TP53
2
Show member pathways
12.23 EGFR ERBB2 TP53
3
Show member pathways
12.22 EGFR ERBB2 PGR TP53
4 12.2 EGFR ERBB2 TP53
5
Show member pathways
12.17 EGFR ERBB2 TP53
6
Show member pathways
12.15 EGFR ERBB2 TP53
7
Show member pathways
12.09 EGFR ERBB2 TP53
8 11.88 EGFR ERBB2 TP53
9
Show member pathways
11.87 EGFR ERBB2 TP53
10 11.7 EGFR ERBB2 TP53
11
Show member pathways
11.59 EGFR ERBB2 TP53
12 11.35 EGFR ERBB2
13 11.29 EGFR TP53
14 11.21 EGFR ERBB2
15 11.2 EGFR ERBB2 TP53
16 11 EGFR TP53
17
Show member pathways
10.96 EGFR ERBB2 PGR S100B
18 10.95 EGFR ERBB2
19 10.94 EGFR ERBB2 TP53
20 10.91 EGFR ERBB2

GO Terms for Microglandular Adenosis

Cellular components related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 EGFR ERBB2 KRT18 PGR PIP S100B
2 basal plasma membrane GO:0009925 8.96 EGFR ERBB2
3 perinuclear region of cytoplasm GO:0048471 8.92 EGFR ERBB2 KRT18 S100B

Biological processes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.56 EGFR ERBB2 KRT18 TP53
2 cellular response to growth factor stimulus GO:0071363 9.48 EGFR ERBB2
3 learning or memory GO:0007611 9.46 EGFR S100B
4 cellular response to epidermal growth factor stimulus GO:0071364 9.43 EGFR ERBB2
5 ERBB2 signaling pathway GO:0038128 9.4 EGFR ERBB2
6 regulation of cell motility GO:2000145 9.37 EGFR ERBB2
7 regulation of ERK1 and ERK2 cascade GO:0070372 9.32 EGFR ERBB2
8 cell proliferation GO:0008283 9.26 EGFR ERBB2 S100B TP53
9 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.16 EGFR TP53
10 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.43 EGFR PGR TP53
2 identical protein binding GO:0042802 9.35 EGFR ERBB2 PGR S100B TP53
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 EGFR ERBB2
4 protein phosphatase binding GO:0019903 8.8 EGFR ERBB2 TP53

Sources for Microglandular Adenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....