MCID: MCR019
MIFTS: 43

Microglandular Adenosis

Aliases & Classifications for Microglandular Adenosis

MalaCards integrated aliases for Microglandular Adenosis:

Name: Microglandular Adenosis 12 15
Breast Fibrocystic Disease 17 70
Fibrocystic Breast Disease 44
Adenosis of the Breast 12
Adenosis of Breast 70
Adenosis - Breast 12
Breast Adenosis 17

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Disease Ontology 12 DOID:5998
MeSH 44 D005348
NCIt 50 C3484
SNOMED-CT 67 270893004
UMLS 70 C0016034 C0085750

Summaries for Microglandular Adenosis

Disease Ontology : 12 A breast disease that is characterized by a haphazard infiltration of small, uniformly open, and round glands which are lined by a monolayer of flat to cuboidal epithelial cells that lack a myoepithelial layer, the absence of stromal desmoplasia and the presence of a thickened basement membrane.

MalaCards based summary : Microglandular Adenosis, also known as breast fibrocystic disease, is related to apocrine adenosis of breast and papilloma. An important gene associated with Microglandular Adenosis is PIP (Prolactin Induced Protein), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Tamoxifen and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and salivary gland, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Microglandular Adenosis

Diseases related to Microglandular Adenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)
# Related Disease Score Top Affiliating Genes
1 apocrine adenosis of breast 32.1 TP53 PGR ERBB2
2 papilloma 30.3 TP53 ERBB2 EGFR
3 basaloid squamous cell carcinoma 30.2 TP53 EGFR
4 tubular adenocarcinoma 29.9 PGR ESR1 ERBB2 EGFR CDH1
5 breast fibroadenoma 29.9 TP53 PGR ESR1 ERBB2
6 breast disease 29.8 TP53 PGR ESR1 ERBB2
7 leiomyoma 29.6 PGR KIT ESR1
8 adenosquamous carcinoma 29.5 TP53 KIT EGFR
9 apocrine adenocarcinoma 29.5 PIP PGR ESR1 ERBB2 EGFR
10 in situ carcinoma 29.4 TP53 PIP PGR ESR1 ERBB2 EGFR
11 cribriform carcinoma 29.2 PIP PGR KIT ESR1 ERBB2
12 ductal carcinoma in situ 29.1 TP53 PIP PGR ESR1 ERBB2 EGFR
13 lobular neoplasia 29.1 TP53 PIP PGR ESR1 ERBB2 CDH1
14 adenoid cystic carcinoma 28.5 TP53 S100B PGR KIT ERBB2 EGFR
15 breast ductal carcinoma 28.4 TP53 PIP PGR ESR1 ERBB2 EGFR
16 microglandular adenosis of breast 11.3
17 proliferative type fibrocystic change of breast 11.2
18 non-proliferative fibrocystic change of the breast 11.2
19 sclerosing adenosis of breast 11.1
20 breast cyst 10.3
21 acinar cell carcinoma 10.3
22 rare tumor 10.3
23 bartholin's gland disease 10.3 PIP PGR
24 glycogen-rich clear cell breast carcinoma 10.3 PIP PGR
25 spiradenoma 10.3 TP53 S100B
26 eccrine papillary adenocarcinoma 10.2 PIP PGR
27 vulva adenocarcinoma 10.2 PIP ERBB2
28 vulval paget's disease 10.2 PIP ERBB2
29 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
30 cutaneous adenocystic carcinoma 10.2 PIP PGR
31 lipid-rich breast carcinoma 10.2 PGR ERBB2
32 syringoma 10.2 S100B ESR1
33 polycystic ovary syndrome 10.2
34 luminal breast carcinoma b 10.2 PGR ERBB2
35 clear cell meningioma 10.2 S100B PGR
36 basaloid lung carcinoma 10.2 TP53 PGR
37 bartholin's gland adenocarcinoma 10.2 PIP PGR
38 eccrine sweat gland cancer 10.2 TP53 PIP
39 gemistocytic astrocytoma 10.2 TP53 S100B
40 triple-receptor negative breast cancer 10.2 PGR ERBB2
41 breast papillomatosis 10.2 PGR ERBB2
42 gastric papillary adenocarcinoma 10.2 TP53 ERBB2
43 bartholin's gland adenoid cystic carcinoma 10.2 PGR ESR1
44 uterine corpus adenosarcoma 10.2 PGR ESR1
45 chronic tympanitis 10.2 PGR ESR1
46 granulomatous endometritis 10.2 PGR ESR1
47 osteochondroma 10.2 S100B ERBB2
48 parotid gland cancer 10.2 TP53 ERBB2
49 lung leiomyoma 10.2 PGR ESR1
50 paget disease, extramammary 10.2 PIP ERBB2

Comorbidity relations with Microglandular Adenosis via Phenotypic Disease Network (PDN):


Breast Fibroadenosis Fat Necrosis of Breast
Female Breast Cancer Hypertension, Essential
Hypothyroidism Mastitis

Graphical network of the top 20 diseases related to Microglandular Adenosis:



Diseases related to Microglandular Adenosis

Symptoms & Phenotypes for Microglandular Adenosis

GenomeRNAi Phenotypes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.8 EGFR
2 Decreased viability GR00055-A-2 9.8 EGFR
3 Decreased viability GR00221-A-1 9.8 CDH1 EGFR ESR1 KIT
4 Decreased viability GR00221-A-2 9.8 ESR1
5 Decreased viability GR00221-A-4 9.8 EGFR ESR1
6 Decreased viability GR00301-A 9.8 CDH1 KIT
7 Decreased viability GR00386-A-1 9.8 ESR1
8 Decreased viability GR00402-S-2 9.8 CDH1 ESR1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.72 EGFR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.72 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.72 KIT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.72 ERBB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.72 ERBB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.72 KIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.72 ERBB2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.72 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.72 S100B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.72 EGFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.72 KIT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.72 ERBB2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.72 EGFR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.72 S100B
23 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.72 ERBB2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.72 KIT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 ERBB2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-66 9.72 S100B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 EGFR ERBB2 KIT
28 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.72 ERBB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.72 KIT
30 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.72 EGFR
31 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.72 KIT

MGI Mouse Phenotypes related to Microglandular Adenosis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 CDH1 EGFR ERBB2 ESR1 KIT PGR
2 cellular MP:0005384 10.11 CDH1 EGFR ERBB2 ESR1 KIT PGR
3 endocrine/exocrine gland MP:0005379 10.06 CDH1 EGFR ERBB2 ESR1 KIT PGR
4 digestive/alimentary MP:0005381 10.04 CDH1 EGFR ERBB2 ESR1 KIT PIP
5 homeostasis/metabolism MP:0005376 10.03 CDH1 EGFR ERBB2 ESR1 KIT PGR
6 embryo MP:0005380 10.02 CDH1 EGFR ERBB2 ESR1 KIT PGR
7 integument MP:0010771 10.01 CDH1 EGFR ERBB2 ESR1 KIT PGR
8 limbs/digits/tail MP:0005371 9.85 EGFR ERBB2 ESR1 KIT PGR TP53
9 muscle MP:0005369 9.8 EGFR ERBB2 ESR1 KIT PGR TP53
10 neoplasm MP:0002006 9.8 CDH1 EGFR ERBB2 ESR1 KIT PGR
11 no phenotypic analysis MP:0003012 9.63 CDH1 EGFR ESR1 KIT PGR TP53
12 normal MP:0002873 9.56 CDH1 EGFR ERBB2 ESR1 KIT PGR
13 reproductive system MP:0005389 9.23 CDH1 EGFR ERBB2 ESR1 KIT PGR

Drugs & Therapeutics for Microglandular Adenosis

Drugs for Microglandular Adenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2
Tocopherol Approved, Investigational Phase 4 1406-66-2
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
4 Tocotrienol Investigational Phase 4 6829-55-6
5 Hormone Antagonists Phase 4
6 Hormones Phase 4
7 Estrogens Phase 4
8 Estrogen Receptor Antagonists Phase 4
9 Estrogen Antagonists Phase 4
10 Evening Primrose Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Antimetabolites Phase 4
13 Antirheumatic Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Lipid Regulating Agents Phase 4
17 Dermatologic Agents Phase 4
18 Hypolipidemic Agents Phase 4
19 Anti-Inflammatory Agents, Non-Steroidal Phase 4
20 Estrogen Receptor Modulators Phase 4
21 Omega 3 Fatty Acid Phase 4
22 Vitamins Phase 4
23 Analgesics Phase 4
24 Tocopherols Phase 4
25 Tocotrienols Phase 4
26
Evening primrose oil Investigational, Nutraceutical Phase 4 308064-97-3
27
Danazol Approved Phase 2 17230-88-5 28417
28
Iodine Approved, Investigational 7553-56-2 807
29
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
30
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
31
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
32
Cadexomer iodine Experimental 94820-09-4
33 Vitamin D2
34 Ergocalciferols
35 Calciferol
36 Calcium, Dietary
37 Trace Elements
38 Nutrients
39 Anti-Infective Agents, Local
40 Anti-Infective Agents
41 Micronutrients
42
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Open, Parallel Controlled Clinical Study on the Efficacy and Safety of the Treatment of Cyclomastopathy With Xiaoru Sanjie Capsule Unknown status NCT02929420 Phase 4 Xiaoru Sanjie capsules;Xiao Yao pills
2 A Single Blinded Randomized Controlled Trial of the Comparative Effects of Tamoxifen and Evening Primrose Oil in Premenopausal Non-high Risk Patients With Benign Breast Disease With Respect to the Estrogen Receptor Status. Completed NCT00999921 Phase 4 Tamoxifen;Evening Primrose Oil
3 Omega-3 Fatty Acids Plus Vitamin E Cosupplementation Versus Vitamin E in Fibrocystic Breast Patient Not yet recruiting NCT04694027 Phase 4 Omega 3 fatty acid;VitaE
4 A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of IoGen™ for the Treatment of Moderate or Severe, Periodic Breast Pain Associated With Symptomatic Fibrocystic Breast Disease Unknown status NCT00237523 Phase 3 IoGen (molecular iodine)
5 Efficacy and Safety of Nutritional Supplement ONCOXIN in Patients With Breast Fibrocystic Disease Completed NCT00967681 Phase 3
6 An Open-Label, MultiCenter Evaluation of the Use of Topically Administered FP1198 in Subjects With Pain Associated With Cyclic Mastalgia Completed NCT01105793 Phase 2 Danazol
7 A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Multicenter Evaluation of the Use of Topically Administered Danazol Versus Placebo in Subjects With Pain Associated With Fibrocystic Breast Disease Completed NCT00744276 Phase 2 danazol;Placebo
8 Window Trial of Abemaciclib for Surgically Resectable, Chemotherapy-Resistant, Triple Negative Breast Cancer (a BEAUTY Study*) Recruiting NCT03979508 Phase 2 Abemaciclib
9 THE EFFECTS OF VITAMIN D ON MAMMOGRAPHIC DENSITY AND BREAST TISSUE Unknown status NCT02239874
10 Central Mammary Duct Excision; How to Improve the Outcome? Completed NCT04744766
11 Genetics of Mammographic Appearances and Patterns (The GenMap Study) Completed NCT01160510
12 Morphometry of Breast Cells in Ductal Lavage Completed NCT00259597
13 A Multi-Center, Prospective Study to Evaluate the Ability of CTC Enumeration Using the CellSearch® Circulating Tumor Cell Kit to Predict Prognosis and to Assess the Agreement Between CTC and Imaging Determined Response in MBC Patients 一项评价CellSearch® 循环肿瘤细胞检测试剂盒对复发转移性乳腺癌患者进行循环肿瘤细胞检测 以预测病人预后的能力及循环肿瘤细胞检测和影像学疗效判断之间一致性的多中心、前瞻性的研究 Completed NCT01116869
14 Qualitative and Quantitative Analysis of Cystic Breast Masses by Contrast Enhanced Ultrasound: Is Biopsy Necessary? Completed NCT02887937 Definity
15 A Comparison of Breast Tomosynthesis Mammography and Conventional Breast Imaging in the Characterization of Breast Masses: A Pilot Study Completed NCT00826488 Early Phase 1
16 A Randomized Double-blind, Placebo Controlled, Multi-center Study to Evaluate the Safety, Tolerability and Potential Effects of the Dietary Supplement Violet™ Molecular Iodine (I2) on Breast Health in Women With Cyclic Breast Discomfort and Tenderness Completed NCT02676336
17 Characterization and Implication of Prolactin Receptor Mutants in Human Breast Diseases Completed NCT00842465
18 for Patients With Fibrocystic Disease of the Breast, Does Pulsed Radiofrequency on Thoracic Paravertebral Nerve Reduce Pain Severity Recruiting NCT03888963
19 Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource (Hepato/Renal Fibrocystic Diseases Core Center (UAB HFRDCC)) Recruiting NCT01401998
20 A Pilot Study of REGENERA Implant in Localized Non- Malignant Breast Lesions Treated by Excision or Lumpectomy Recruiting NCT04131972
21 Prospective Cohort Study of Mastectomy With Reconstruction Including Robot Endoscopic Breast Surgery Recruiting NCT04585074
22 Johns Hopkins Breast Cancer Program Longitudinal Repository Recruiting NCT01937039
23 Risk Factors for Benign Breast Disease in Young Adult Women. Case-control Study Recruiting NCT04127422
24 Promoting Earlier Detection of Breast Cancer in Rwanda: Scaleup in the National Health Care System Not yet recruiting NCT04258085
25 Involvement of Endogenous Digitalis-like Compounds in Breast Cancer Withdrawn NCT00310882

Search NIH Clinical Center for Microglandular Adenosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Danazol

Cochrane evidence based reviews: fibrocystic breast disease

Genetic Tests for Microglandular Adenosis

Anatomical Context for Microglandular Adenosis

MalaCards organs/tissues related to Microglandular Adenosis:

40
Breast, Prostate, Salivary Gland

Publications for Microglandular Adenosis

Articles related to Microglandular Adenosis:

(show top 50) (show all 111)
# Title Authors PMID Year
1
Retinoic acid receptors alpha, beta and gamma, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer. 54 61
9368510 1997
2
Morphologic and immunohistochemical features of carcinoma involving microglandular adenosis of the breast following neoadjuvant chemotherapy. 61
33649459 2021
3
Chromosome 2q gain and epigenetic silencing of GATA3 in microglandular adenosis of the breast. 61
33382535 2020
4
[Microglandular adenosis of the breast in a patient with a history of mediastinal radiotherapy]. 61
33012496 2020
5
Analysis of the radio-pathological factors of triple negative breast cancer and determination of risk profiles. 61
32093905 2020
6
Microglandular Adenosis and Associated Invasive Carcinoma. 61
31116044 2020
7
Salivary gland-type mammary carcinoma arising in microglandular adenosis: A case report and clinicopathological review of the literature. 61
32454386 2020
8
Microglandular Adenosis: A Possible Non-Obligate Precursor to Breast Carcinoma With Potential to Either Luminal-Type or Basal-Type Differentiation. 61
31046496 2019
9
Microglandular adenosis is an advanced precursor breast lesion with evidence of molecular progression to matrix-producing metaplastic carcinoma. 61
30428388 2019
10
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion. 61
29949742 2018
11
Invasion in breast lesions: the role of the epithelial-stroma barrier. 61
29197112 2018
12
Metaplastic Carcinoma With Extensive Chondromyxoid Differentiation Arising in Association With Microglandular Adenosis. 61
28381146 2017
13
[Clinicopathologic features of mammary microglandular adenosis with carcinoma: a study of 5 cases]. 61
28810292 2017
14
Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases. 61
28372344 2017
15
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. 61
28498281 2017
16
Metaplastic Carcinoma with Chondroid Differentiation Arising in Microglandular Adenosis. 61
28372347 2017
17
The evaluation of the effect of metformin on breast fibrocystic disease. 61
28598826 2017
18
Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family. 61
27713419 2017
19
Pathologic Spectrum of Secretory and Mucinous Breast Lesions. 61
27362569 2016
20
Breast atypical microglandular adenosis can be a diagnostic pitfall on fine-needle aspiration samples. 61
26991047 2016
21
Microglandular adenosis: a prime suspect in triple-negative breast cancer development. 61
27061094 2016
22
Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype. 61
27067778 2016
23
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations. 61
26806567 2016
24
Vulval Microglandular Adenosis-like Neoplasm With Chondromyxoid Stroma: Report of a Unique Case. 61
26535982 2016
25
Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants. 61
28721389 2016
26
Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management. 61
26348644 2016
27
Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial. 61
26621682 2016
28
Mammographic and Ultrasonographic Findings of Different Breast Adenosis Lesions. 61
30039060 2015
29
A case of matrix-producing carcinoma of the breast with micoglandular adenosis and review of literature. 61
26339435 2015
30
Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology. 61
25337263 2014
31
Invasive breast carcinoma arising in microglandular adenosis: two case reports. 61
24454466 2013
32
Secretory carcinoma of the breast and its histopathological mimics: value of markers for differential diagnosis. 61
23944930 2013
33
Microglandular adenosis: a non-obligate precursor of triple-negative breast cancer? 61
23584829 2013
34
Acinic cell carcinoma of the breast arising in microglandular adenosis. 61
24369519 2013
35
Adenomyoepithelioma with ductal carcinoma in situ: a case report and review of the literature. 61
23533914 2013
36
Small Glandular Proliferations of the Breast. 61
26838282 2012
37
Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. 61
22486256 2012
38
Differential diagnosis between sclerosing adenosis and tubular carcinoma of the breast under transmission and scanning electron microscope. 61
21910568 2011
39
Microglandular adenosis with transition to breast carcinoma: a series of three cases. 61
21753716 2011
40
Matrix-producing carcinoma of the breast in the Chinese population: a clinicopathological study of 13 cases. 61
21707845 2011
41
[Invasive carcinoma arising in breast microglandular adenosis: a clinicopathologic study of three cases and review of the literature]. 61
22088374 2011
42
Paneth cell-like eosinophilic cytoplasmic granules in breast carcinoma. 61
21163678 2011
43
Microglandular adenosis. 61
21847399 2011
44
Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases. 61
20922408 2010
45
Young-aged woman with invasive ductal carcinoma arising in atypical microglandular adenosis: a case report. 61
20846267 2010
46
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma. 61
19922592 2009
47
Prostate specific antigen in women with menstrual disturbances and fibrocystic mastopathy. 54
19602918 2009
48
Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature. 61
19824997 2009
49
[Diagnostic pitfalls in mammary pathology. Case 4. Microglandular adenosis]. 61
19619827 2009
50
Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma. 61
19047897 2009

Variations for Microglandular Adenosis

Expression for Microglandular Adenosis

Search GEO for disease gene expression data for Microglandular Adenosis.

Pathways for Microglandular Adenosis

Pathways related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TP53 S100B PGR KIT ESR1 ERBB2
2
Show member pathways
13.54 TP53 PIP KIT ESR1 ERBB2 EGFR
3
Show member pathways
13.19 TP53 PIP KIT ERBB2 EGFR
4
Show member pathways
13.08 PIP KIT ERBB2 EGFR CDH1
5
Show member pathways
13.05 KIT ESR1 ERBB2 EGFR CDH1
6
Show member pathways
12.79 TP53 KIT ERBB2 EGFR
7
Show member pathways
12.75 KIT ERBB2 EGFR CDH1
8
Show member pathways
12.65 TP53 KIT ERBB2 EGFR CDH1
9 12.54 TP53 KIT ERBB2 EGFR
10
Show member pathways
12.51 TP53 KIT ERBB2 EGFR
11
Show member pathways
12.48 TP53 ESR1 ERBB2 CDH1
12
Show member pathways
12.4 TP53 ESR1 ERBB2 EGFR CDH1
13 12.36 TP53 KIT ESR1 ERBB2 EGFR CDH1
14
Show member pathways
12.19 KIT ERBB2 EGFR CDH1
15
Show member pathways
12.17 ERBB2 EGFR CDH1
16
Show member pathways
12.14 ESR1 ERBB2 EGFR
17
Show member pathways
12.13 TP53 ERBB2 EGFR
18 12.09 TP53 ESR1 ERBB2 EGFR
19 12.03 TP53 EGFR CDH1
20 11.95 TP53 ESR1 EGFR CDH1
21 11.94 KIT ERBB2 EGFR
22
Show member pathways
11.83 TP53 ERBB2 EGFR
23
Show member pathways
11.83 TP53 PGR KIT ESR1 ERBB2 EGFR
24
Show member pathways
11.64 KIT ESR1 ERBB2 EGFR
25 11.56 ERBB2 EGFR CDH1
26 11.49 TP53 ERBB2 EGFR CDH1
27 11.4 TP53 KIT ERBB2 EGFR
28
Show member pathways
11.39 S100B PGR ESR1 ERBB2 EGFR
29 11.18 TP53 EGFR
30 11.13 ERBB2 EGFR
31 11.1 ERBB2 EGFR CDH1
32 10.9 EGFR CDH1
33 10.8 PIP KIT ERBB2 EGFR CDH1

GO Terms for Microglandular Adenosis

Cellular components related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 KIT ERBB2 EGFR

Biological processes related to Microglandular Adenosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.85 S100B KIT ERBB2 EGFR
2 positive regulation of gene expression GO:0010628 9.84 TP53 PIP KIT ERBB2
3 regulation of transcription by RNA polymerase II GO:0006357 9.8 TP53 PGR KIT ESR1 ERBB2 EGFR
4 protein autophosphorylation GO:0046777 9.73 KIT ERBB2 EGFR
5 peptidyl-tyrosine phosphorylation GO:0018108 9.7 KIT ERBB2 EGFR
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.69 KIT ERBB2 EGFR
7 stem cell differentiation GO:0048863 9.6 KIT ESR1
8 regulation of cell motility GO:2000145 9.59 ERBB2 EGFR
9 regulation of ERK1 and ERK2 cascade GO:0070372 9.58 ERBB2 EGFR
10 ERBB2 signaling pathway GO:0038128 9.58 ERBB2 EGFR
11 steroid hormone mediated signaling pathway GO:0043401 9.57 PGR ESR1
12 positive regulation of phospholipase C activity GO:0010863 9.49 KIT ESR1
13 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.48 TP53 EGFR
14 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.46 TP53 ESR1
15 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.43 TP53 ESR1
16 positive regulation of kinase activity GO:0033674 9.43 KIT ERBB2 EGFR
17 tongue development GO:0043586 9.4 KIT EGFR
18 intracellular steroid hormone receptor signaling pathway GO:0030518 9.37 PGR ESR1
19 negative regulation of ERBB signaling pathway GO:1901185 9.16 ERBB2 EGFR
20 positive regulation of MAP kinase activity GO:0043406 9.13 KIT ERBB2 EGFR
21 positive regulation of protein kinase B signaling GO:0051897 8.92 KIT ESR1 ERBB2 EGFR

Molecular functions related to Microglandular Adenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 TP53 PGR ESR1 EGFR
2 protein tyrosine kinase activity GO:0004713 9.58 KIT ERBB2 EGFR
3 protein phosphatase binding GO:0019903 9.5 TP53 ERBB2 EGFR
4 steroid binding GO:0005496 9.46 PGR ESR1
5 steroid hormone receptor activity GO:0003707 9.43 PGR ESR1
6 ATPase binding GO:0051117 9.33 PGR ESR1 EGFR
7 nitric-oxide synthase regulator activity GO:0030235 9.26 ESR1 EGFR
8 identical protein binding GO:0042802 9.23 TP53 S100B PIP PGR ESR1 ERBB2
9 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 KIT ERBB2 EGFR

Sources for Microglandular Adenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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