MCID: MCR015
MIFTS: 22

Microinvasive Cervical Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Microinvasive Cervical Squamous Cell Carcinoma

MalaCards integrated aliases for Microinvasive Cervical Squamous Cell Carcinoma:

Name: Microinvasive Cervical Squamous Cell Carcinoma 12 15
Early Invasive Cervical Squamous Cell Carcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:8409
NCIt 50 C36094
UMLS 70 C1333370

Summaries for Microinvasive Cervical Squamous Cell Carcinoma

Disease Ontology : 12 A cervical squamous cell carcinoma that is characterized by invasion which diagnosed by microscopy only. Invasion is limited to measured stromal invasion with a maximum depth of 5 mm and no wider than 7 mm diameter.

MalaCards based summary : Microinvasive Cervical Squamous Cell Carcinoma, also known as early invasive cervical squamous cell carcinoma, is related to cervix uteri carcinoma in situ and hemometra. An important gene associated with Microinvasive Cervical Squamous Cell Carcinoma is INSM1 (INSM Transcriptional Repressor 1). Affiliated tissues include uterus and cervix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Microinvasive Cervical Squamous Cell Carcinoma

Diseases related to Microinvasive Cervical Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 cervix uteri carcinoma in situ 30.5 PTPRN INSM1
2 hemometra 10.2 PTPRN INSM1
3 isthmus cancer 10.2 PTPRN INSM1
4 lymphocele 10.2 PTPRN INSM1
5 bleeding disorder, platelet-type, 17 10.2 PTPRN INSM1
6 cervical incompetence 10.2 PTPRN INSM1
7 fallopian tube endometrioid adenocarcinoma 10.2 PTPRN INSM1
8 squamous cell carcinoma 10.2
9 cervical squamous cell carcinoma 10.2
10 cervical intraepithelial neoplasia 10.2
11 parametritis 10.2 PTPRN INSM1
12 uterus carcinoma in situ 10.2 PTPRN INSM1
13 spermatic cord cancer 10.1 WT1 KRT5
14 colon leiomyosarcoma 10.1 WT1 KRT5
15 testicular fibroma 10.1 WT1 KRT5
16 malignant biphasic mesothelioma 10.1 WT1 KRT5
17 cervical serous adenocarcinoma 10.0 WT1 GATA3
18 small intestinal sarcoma 10.0 WT1 PTPRC
19 brachydactyly, type c 10.0 PTPRN PTPRC
20 thymus gland disease 10.0 PTPRC KRT5
21 ureter squamous cell carcinoma 10.0 KRT7 KRT5
22 ceruminoma 10.0 KRT7 KRT5
23 ureter adenocarcinoma 10.0 KRT7 KRT5
24 subareolar duct papillomatosis 10.0 KRT7 KRT5
25 malignant acrospiroma 10.0 KRT7 KRT5
26 nipple benign neoplasm 10.0 KRT7 KRT5
27 auditory system benign neoplasm 10.0 KRT7 KRT5
28 ceruminous adenocarcinoma 10.0 KRT7 KRT5
29 cutaneous mucoepidermoid carcinoma 10.0 KRT7 KRT5
30 external ear carcinoma 10.0 KRT7 KRT5
31 benign breast adenomyoepithelioma 10.0 KRT7 KRT5
32 eccrine adenocarcinoma 10.0 KRT7 KRT5
33 lung clear cell carcinoma 10.0 KRT7 KRT5
34 necrotizing sialometaplasia 10.0 KRT7 KRT5
35 vaginal cancer 10.0 KRT7 INSM1
36 sensory organ benign neoplasm 10.0 KRT7 KRT5
37 malignant syringoma 10.0 KRT7 KRT5
38 gastric squamous cell carcinoma 10.0 KRT7 KRT5
39 bile duct mucoepidermoid carcinoma 10.0 KRT7 KRT5
40 dopamine beta-hydroxylase deficiency 10.0 WT1 GATA3
41 squamous cell bile duct carcinoma 10.0 KRT7 KRT5
42 middle ear adenocarcinoma 10.0 KRT7 KRT5
43 breast metaplastic carcinoma 10.0 KRT7 KRT5
44 large cell acanthoma 10.0 KRT7 KRT5
45 breast mucinous carcinoma 10.0 KRT7 KRT5
46 balloon cell malignant melanoma 9.9 KRT7 KRT5
47 clear cell hidradenoma 9.9 KRT7 KRT5
48 hidradenoma 9.9 KRT7 KRT5
49 eccrine sweat gland cancer 9.9 KRT7 KRT5
50 sarcomatoid mesothelioma 9.9 WT1 GATA3

Graphical network of the top 20 diseases related to Microinvasive Cervical Squamous Cell Carcinoma:



Diseases related to Microinvasive Cervical Squamous Cell Carcinoma

Symptoms & Phenotypes for Microinvasive Cervical Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Microinvasive Cervical Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.02 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.02 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.02 KRT5 KRT7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.02 INSM1

Drugs & Therapeutics for Microinvasive Cervical Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Microinvasive Cervical Squamous Cell Carcinoma

Genetic Tests for Microinvasive Cervical Squamous Cell Carcinoma

Anatomical Context for Microinvasive Cervical Squamous Cell Carcinoma

MalaCards organs/tissues related to Microinvasive Cervical Squamous Cell Carcinoma:

40
Uterus, Cervix

Publications for Microinvasive Cervical Squamous Cell Carcinoma

Articles related to Microinvasive Cervical Squamous Cell Carcinoma:

# Title Authors PMID Year
1
Microinvasive cervical squamous cell carcinoma in Slovenia during the period 2001-2007. 61
25177242 2014
2
Unusual form of superficial spreading microinvasive squamous cell carcinoma of uterine cervix involving the endometrium of uterus. 61
15327449 2004
3
Karyometric features differentiate early invasive cervical squamous cell carcinoma from preinvasive carcinoma. 61
11915180 2001

Variations for Microinvasive Cervical Squamous Cell Carcinoma

Expression for Microinvasive Cervical Squamous Cell Carcinoma

Search GEO for disease gene expression data for Microinvasive Cervical Squamous Cell Carcinoma.

Pathways for Microinvasive Cervical Squamous Cell Carcinoma

GO Terms for Microinvasive Cervical Squamous Cell Carcinoma

Biological processes related to Microinvasive Cervical Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to estrogen GO:0043627 9.46 PTPRN GATA3
2 positive regulation of cell differentiation GO:0045597 9.43 INSM1 GATA3
3 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.4 WT1 GATA3
4 T cell differentiation GO:0030217 9.37 PTPRC GATA3
5 negative regulation of interleukin-2 production GO:0032703 9.32 PTPRC GATA3
6 response to gamma radiation GO:0010332 9.26 PTPRC GATA3
7 positive regulation of T cell differentiation GO:0045582 9.16 PTPRC GATA3
8 mesenchymal to epithelial transition GO:0060231 8.96 WT1 GATA3
9 norepinephrine biosynthetic process GO:0042421 8.62 INSM1 GATA3

Molecular functions related to Microinvasive Cervical Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spectrin binding GO:0030507 8.62 PTPRN PTPRC

Sources for Microinvasive Cervical Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....