MCID: MCR016
MIFTS: 40

Micronodular Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Micronodular Basal Cell Carcinoma

MalaCards integrated aliases for Micronodular Basal Cell Carcinoma:

Name: Micronodular Basal Cell Carcinoma 12 15
Skin Micronodular Basal Cell Carcinoma 12
Basal Cell Carcinoma, Micronodular 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4289
UMLS 71 C1367861

Summaries for Micronodular Basal Cell Carcinoma

Disease Ontology : 12 A basal cell carcinoma characterized by solid tumor nodules.

MalaCards based summary : Micronodular Basal Cell Carcinoma, also known as skin micronodular basal cell carcinoma, is related to basal cell carcinoma and nodular basal cell carcinoma. An important gene associated with Micronodular Basal Cell Carcinoma is KRT15 (Keratin 15), and among its related pathways/superpathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Pathways in cancer. Affiliated tissues include skin and smooth muscle, and related phenotypes are behavior/neurological and cellular

Related Diseases for Micronodular Basal Cell Carcinoma

Diseases related to Micronodular Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 27.7 TP53 SOX9 SHH PTCH1 MME KRT5
2 nodular basal cell carcinoma 10.5 PTCH1 KRT15
3 eccrine porocarcinoma 10.5 KRT5 KRT15
4 benign breast adenomyoepithelioma 10.5 KRT5 KRT14
5 breast adenomyoepithelioma 10.5 KRT5 KRT14
6 metatypical basal cell carcinoma 10.5 PTCH1 KRT5
7 holoprosencephaly, recurrent infections, and monocytosis 10.5 PTCH1 GLI2
8 pregnancy adenoma 10.4 KRT5 KRT14
9 ceruminous adenocarcinoma 10.4 KRT5 KRT14
10 breast myoepithelial neoplasm 10.4 KRT5 KRT14
11 focal epithelial hyperplasia 10.4 KRT15 KRT14
12 breast metaplastic carcinoma 10.4 KRT5 KRT14
13 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT5 KRT14
14 odontoma 10.4 KRT5 KRT14
15 fibroepithelial basal cell carcinoma 10.4 PTCH1 KRT14
16 breast myoepithelial carcinoma 10.4 KRT5 KRT14
17 lipid-rich carcinoma 10.4 KRT5 KRT14
18 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT5 KRT14
19 holoprosencephaly 9 10.4 PTCH1 GLI2
20 epidermolysis bullosa simplex, generalized 10.4 KRT5 KRT14
21 sensory organ benign neoplasm 10.4 NRAS KRT5
22 apocrine adenocarcinoma 10.4 KRT5 KRT14
23 epidermolysis bullosa simplex, localized 10.3 KRT5 KRT14
24 superficial basal cell carcinoma 10.3 TLR7 PTCH1
25 hymenolepiasis 10.3 IFNA1 C1orf56
26 malignant spiradenoma 10.3 TP53 KRT5
27 mucoepidermoid esophageal carcinoma 10.3 TP53 KRT5
28 apocrine sweat gland neoplasm 10.3 KRT5 KRT15 KRT14
29 subareolar duct papillomatosis 10.3 MME KRT5
30 nipple neoplasm 10.3 MME KRT5
31 sweat gland disease 10.3 KRT5 KRT15 KRT14
32 cervix erosion 10.3 MME KRT5
33 eccrine papillary adenocarcinoma 10.3 MME KRT5
34 sarcomatoid squamous cell skin carcinoma 10.3 MME KRT5
35 necrotizing sialometaplasia 10.3 TP53 KRT5
36 epidermolysis bullosa 10.3 KRT5 KRT15 KRT14
37 hair follicle neoplasm 10.3 KRT15 KRT14
38 epidermolysis bullosa simplex 10.3 KRT5 KRT15 KRT14
39 clear cell hidradenoma 10.3 MME KRT5
40 nephrogenic adenoma of the urethra 10.3 MME KRT5
41 urethral benign neoplasm 10.3 MME KRT5
42 benign struma ovarii 10.3 PTCH1 NRAS
43 balloon cell malignant melanoma 10.3 MME KRT5
44 basosquamous carcinoma 10.3 TP53 PTCH1
45 epididymis adenocarcinoma 10.3 MME KRT5
46 conjunctival squamous cell carcinoma 10.3 TP53 KRT15
47 epididymis cancer 10.3 MME KRT5
48 chondrodysplasia-pseudohermaphroditism syndrome 10.2 SOX9 PTCH1
49 spiradenoma 10.2 TP53 KRT14
50 intracystic papillary adenoma 10.2 KRT5 KRT14

Graphical network of the top 20 diseases related to Micronodular Basal Cell Carcinoma:



Diseases related to Micronodular Basal Cell Carcinoma

Symptoms & Phenotypes for Micronodular Basal Cell Carcinoma

MGI Mouse Phenotypes related to Micronodular Basal Cell Carcinoma:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 C1orf56 EPCAM GLI2 KRT5 MME NRAS
2 cellular MP:0005384 10.19 EPCAM GLI2 KRT14 MME NRAS PTCH1
3 digestive/alimentary MP:0005381 10.16 EPCAM GLI2 KRT14 KRT15 KRT5 NRAS
4 homeostasis/metabolism MP:0005376 10.11 EPCAM GLI2 KRT14 KRT15 MME NRAS
5 craniofacial MP:0005382 10.08 GLI2 KRT14 KRT5 NRAS PTCH1 SHH
6 endocrine/exocrine gland MP:0005379 10.03 EPCAM GLI2 KRT14 NRAS PTCH1 SHH
7 immune system MP:0005387 9.97 EPCAM KRT14 MME NRAS PTCH1 SHH
8 integument MP:0010771 9.91 GLI2 KRT14 KRT5 MME NRAS PTCH1
9 hearing/vestibular/ear MP:0005377 9.88 GLI2 KRT14 PTCH1 SHH SOX9 TP53
10 limbs/digits/tail MP:0005371 9.7 GLI2 KRT5 NRAS PTCH1 SHH SOX9
11 mortality/aging MP:0010768 9.7 EPCAM GLI2 HAUS3 KRT14 KRT5 NRAS
12 no phenotypic analysis MP:0003012 9.23 EPCAM GLI2 KRT5 NRAS PTCH1 SHH

Drugs & Therapeutics for Micronodular Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Micronodular Basal Cell Carcinoma

Genetic Tests for Micronodular Basal Cell Carcinoma

Anatomical Context for Micronodular Basal Cell Carcinoma

MalaCards organs/tissues related to Micronodular Basal Cell Carcinoma:

40
Skin, Smooth Muscle

Publications for Micronodular Basal Cell Carcinoma

Articles related to Micronodular Basal Cell Carcinoma:

# Title Authors PMID Year
1
Line scanning, stage scanning confocal microscope (LSSSCM). 61
28856051 2017
2
Micronodular basal cell carcinoma: a distinct subtype? Relationship with nodular and infiltrative basal cell carcinomas. 61
20629826 2010
3
A correlation of alpha-smooth muscle actin and invasion in micronodular basal cell carcinoma. 61
11359490 2001
4
Micronodular basal cell carcinoma. A deceptive histologic subtype with frequent clinically undetected tumor extension. 61
8607634 1996

Variations for Micronodular Basal Cell Carcinoma

Cosmic variations for Micronodular Basal Cell Carcinoma:

9 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
2 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
3 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
4 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
5 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
6 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
7 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
8 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
9 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
10 COSM87027025 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
11 COSM87028684 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
12 COSM90144180 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 3
13 COSM88644633 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 3
14 COSM87925664 TP53 skin,NS,carcinoma,basal cell carcinoma c.477C>T p.A159= 17:7675135-7675135 3
15 COSM87919454 TP53 skin,NS,carcinoma,basal cell carcinoma c.395A>T p.K132M 17:7675217-7675217 3
16 COSM88272290 TP53 skin,NS,carcinoma,basal cell carcinoma c.480G>C p.M160I 17:7675132-7675132 3
17 COSM87898709 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 3
18 COSM87910628 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 3
19 COSM88387703 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 3
20 COSM87963219 TP53 skin,NS,carcinoma,basal cell carcinoma c.292C>T p.P98S 17:7676077-7676077 3
21 COSM87929396 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 3
22 COSM87898723 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
23 COSM88310572 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 3
24 COSM87898714 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 3
25 COSM87898991 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 3
26 COSM88408340 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 3
27 COSM87906968 TP53 skin,NS,carcinoma,basal cell carcinoma c.833C>T p.P278L 17:7673787-7673787 3
28 COSM87910495 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 3
29 COSM87899497 TP53 skin,NS,carcinoma,basal cell carcinoma c.586C>T p.R196* 17:7674945-7674945 3
30 COSM87906130 TP53 skin,NS,carcinoma,basal cell carcinoma c.854A>T p.E285V 17:7673766-7673766 3
31 COSM87919200 TP53 skin,NS,carcinoma,basal cell carcinoma c.511G>C p.E171Q 17:7675101-7675101 3
32 COSM87944274 TP53 skin,NS,carcinoma,basal cell carcinoma c.419C>T p.T140I 17:7675193-7675193 3
33 COSM87921224 TP53 skin,NS,carcinoma,basal cell carcinoma c.835G>A p.G279R 17:7673785-7673785 3
34 COSM87898567 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 3
35 COSM87900980 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 3
36 COSM87947692 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 3
37 COSM87957813 TP53 skin,NS,carcinoma,basal cell carcinoma c.737T>G p.M246R 17:7674226-7674226 3
38 COSM87904406 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 3
39 COSM87917387 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 3
40 COSM87932688 TP53 skin,NS,carcinoma,basal cell carcinoma c.507G>A p.M169I 17:7675105-7675105 3
41 COSM87903307 TP53 skin,NS,carcinoma,basal cell carcinoma c.841G>A p.D281N 17:7673779-7673779 3
42 COSM87905687 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 3
43 COSM87899661 TP53 skin,NS,carcinoma,basal cell carcinoma c.797G>A p.G266E 17:7673823-7673823 3
44 COSM87908365 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 3
45 COSM87961406 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 3
46 COSM87918616 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 3
47 COSM87897745 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 3
48 COSM87911563 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 3
49 COSM87922049 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 3
50 COSM87898431 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 3

Expression for Micronodular Basal Cell Carcinoma

Search GEO for disease gene expression data for Micronodular Basal Cell Carcinoma.

Pathways for Micronodular Basal Cell Carcinoma

GO Terms for Micronodular Basal Cell Carcinoma

Biological processes related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.03 TP53 SOX9 SHH PTCH1 GLI2
2 negative regulation of apoptotic process GO:0043066 9.98 TP53 SOX9 SHH GLI2 EPCAM
3 heart development GO:0007507 9.89 TP53 SOX9 SHH GLI2
4 central nervous system development GO:0007417 9.85 TP53 SOX9 SHH
5 kidney development GO:0001822 9.82 SHH MME GLI2
6 cornification GO:0070268 9.81 KRT5 KRT15 KRT14
7 lung development GO:0030324 9.8 SHH MME GLI2
8 smoothened signaling pathway GO:0007224 9.75 SHH PTCH1 GLI2
9 pattern specification process GO:0007389 9.72 SHH PTCH1 GLI2
10 hindbrain development GO:0030902 9.67 SHH GLI2
11 morphogenesis of an epithelium GO:0002009 9.67 SOX9 GLI2
12 negative regulation of chondrocyte differentiation GO:0032331 9.66 SOX9 GLI2
13 osteoblast development GO:0002076 9.66 SHH GLI2
14 anatomical structure formation involved in morphogenesis GO:0048646 9.65 SHH GLI2
15 epithelial tube branching involved in lung morphogenesis GO:0060441 9.65 SOX9 SHH
16 somite development GO:0061053 9.65 SHH PTCH1
17 branching involved in ureteric bud morphogenesis GO:0001658 9.65 SOX9 SHH PTCH1
18 replicative senescence GO:0090399 9.63 TP53 MME
19 dorsal/ventral pattern formation GO:0009953 9.63 SHH PTCH1 GLI2
20 hemidesmosome assembly GO:0031581 9.62 KRT5 KRT14
21 epidermis development GO:0008544 9.62 PTCH1 KRT5 KRT15 KRT14
22 renal system development GO:0072001 9.61 SHH PTCH1
23 limb bud formation GO:0060174 9.61 SOX9 SHH
24 positive regulation of T cell differentiation in thymus GO:0033089 9.6 SHH GLI2
25 embryonic organ development GO:0048568 9.58 TP53 SHH PTCH1
26 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 9.57 PTCH1 GLI2
27 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.56 SOX9 SHH
28 regulation of cell proliferation GO:0042127 9.55 TP53 SOX9 SHH PTCH1 C1orf56
29 mammary gland duct morphogenesis GO:0060603 9.54 PTCH1 GLI2
30 mammary gland development GO:0030879 9.54 SOX9 PTCH1 GLI2
31 spinal cord dorsal/ventral patterning GO:0021513 9.52 SHH GLI2
32 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.51 SHH GLI2
33 hindgut morphogenesis GO:0007442 9.49 SHH GLI2
34 ventral midline development GO:0007418 9.43 SHH GLI2
35 spinal cord motor neuron differentiation GO:0021522 9.43 SHH PTCH1 GLI2
36 prostate gland development GO:0030850 9.13 SOX9 SHH PTCH1
37 dorsal/ventral neural tube patterning GO:0021904 8.8 SHH PTCH1 GLI2

Molecular functions related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 KRT5 KRT15 KRT14
2 patched binding GO:0005113 8.62 SHH PTCH1

Sources for Micronodular Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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