MCID: MCR016
MIFTS: 34

Micronodular Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Micronodular Basal Cell Carcinoma

MalaCards integrated aliases for Micronodular Basal Cell Carcinoma:

Name: Micronodular Basal Cell Carcinoma 12 15
Skin Micronodular Basal Cell Carcinoma 12
Basal Cell Carcinoma, Micronodular 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4289
UMLS 70 C1367861

Summaries for Micronodular Basal Cell Carcinoma

Disease Ontology : 12 A basal cell carcinoma characterized by solid tumor nodules.

MalaCards based summary : Micronodular Basal Cell Carcinoma, also known as skin micronodular basal cell carcinoma, is related to basal cell carcinoma and malignant syringoma. An important gene associated with Micronodular Basal Cell Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Keratinization and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin and smooth muscle, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Micronodular Basal Cell Carcinoma

Diseases related to Micronodular Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 29.2 SOX9 PTCH1 MME KRT5 KRT15 KRT14
2 malignant syringoma 10.3 KRT5 KRT15
3 eccrine sweat gland cancer 10.3 KRT5 KRT15
4 sweat gland cancer 10.3 KRT5 KRT15
5 eccrine acrospiroma 10.2 KRT5 KRT15
6 ceruminous adenocarcinoma 10.2 KRT5 KRT14
7 benign breast adenomyoepithelioma 10.2 KRT5 KRT14
8 breast adenomyoepithelioma 10.2 KRT5 KRT14
9 breast myoepithelial neoplasm 10.2 KRT5 KRT14
10 breast myoepithelial carcinoma 10.2 KRT5 KRT14
11 squamous cell bile duct carcinoma 10.2 KRT5 KRT14
12 large cell acanthoma 10.2 KRT5 KRT14
13 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT5 KRT14
14 odontoma 10.2 KRT5 KRT14
15 lipid-rich carcinoma 10.2 KRT5 KRT14
16 eccrine papillary adenocarcinoma 10.2 KRT5 KRT14
17 fibroma 10.2 PTCH1 KRT14
18 esophageal adenosquamous carcinoma 10.2 KRT5 KRT14
19 fibroepithelial basal cell carcinoma 10.2 PTCH1 KRT14
20 intracystic papillary adenoma 10.2 KRT5 KRT14
21 synchronous bilateral breast carcinoma 10.2 KRT5 KRT14
22 intraductal papilloma 10.2 KRT5 KRT14
23 epidermolysis bullosa simplex, localized 10.2 KRT5 KRT14
24 epidermolysis bullosa simplex, generalized 10.2 KRT5 KRT14
25 spiradenoma 10.2 KRT15 KRT14
26 sebaceous adenocarcinoma 10.2 KRT5 KRT14
27 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT5 KRT14
28 epidermolysis bullosa simplex, dowling-meara type 10.1 KRT5 KRT14
29 conjunctival squamous cell carcinoma 10.1 KRT15 IFNA1
30 nivelon-nivelon-mabille syndrome 10.1 SOX9 PTCH1
31 tonsil cancer 10.1 KRT5 KRT14
32 epidermolysis bullosa dystrophica 10.1 KRT5 KRT14
33 eccrine sweat gland neoplasm 10.1 KRT5 KRT15 KRT14
34 apocrine sweat gland neoplasm 10.1 KRT5 KRT15 KRT14
35 pilomatrixoma 10.1 KRT15 KRT14
36 peritoneum cancer 10.1 KRT5 EPCAM
37 eccrine papillary adenoma 10.1 KRT5 KRT15 KRT14
38 hair follicle neoplasm 10.1 KRT5 KRT15 KRT14
39 sweat gland disease 10.1 KRT5 KRT15 KRT14
40 keratoacanthoma 10.0 KRT15 KRT14
41 clear cell basal cell carcinoma 10.0 PTCH1 KRT5 KRT14
42 dowling-degos disease 10.0 KRT5 KRT14
43 epidermolysis bullosa 10.0 KRT5 KRT15 KRT14
44 epidermolysis bullosa simplex 10.0 KRT5 KRT15 KRT14
45 superficial basal cell carcinoma 10.0 TLR7 IFNA1
46 skin benign neoplasm 10.0 PTCH1 KRT5 KRT14
47 pachyonychia congenita 1 10.0 KRT5 KRT14
48 cervix erosion 10.0 MME KRT5
49 subareolar duct papillomatosis 10.0 MME KRT5
50 nipple benign neoplasm 10.0 MME KRT5

Graphical network of the top 20 diseases related to Micronodular Basal Cell Carcinoma:



Diseases related to Micronodular Basal Cell Carcinoma

Symptoms & Phenotypes for Micronodular Basal Cell Carcinoma

GenomeRNAi Phenotypes related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.6 IFNA1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-125 9.6 EPCAM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.6 IFNA1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.6 EPCAM
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.6 EPCAM
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 9.6 IFNA1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.6 PTCH1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 9.6 PTCH1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.6 IFNA1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 9.6 IFNA1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.6 IFNA1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.6 EPCAM
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.6 EPCAM IFNA1 PTCH1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.6 IFNA1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.6 PTCH1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-88 9.6 IFNA1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-92 9.6 EPCAM

MGI Mouse Phenotypes related to Micronodular Basal Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 EPCAM KRT14 KRT15 KRT5 PTCH1 SOX9
2 immune system MP:0005387 9.17 EPCAM KRT14 KRT5 MME PTCH1 SOX9

Drugs & Therapeutics for Micronodular Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Micronodular Basal Cell Carcinoma

Genetic Tests for Micronodular Basal Cell Carcinoma

Anatomical Context for Micronodular Basal Cell Carcinoma

MalaCards organs/tissues related to Micronodular Basal Cell Carcinoma:

40
Skin, Smooth Muscle

Publications for Micronodular Basal Cell Carcinoma

Articles related to Micronodular Basal Cell Carcinoma:

# Title Authors PMID Year
1
Line scanning, stage scanning confocal microscope (LSSSCM). 61
28856051 2017
2
Micronodular basal cell carcinoma: a distinct subtype? Relationship with nodular and infiltrative basal cell carcinomas. 61
20629826 2010
3
A correlation of alpha-smooth muscle actin and invasion in micronodular basal cell carcinoma. 61
11359490 2001
4
Micronodular basal cell carcinoma. A deceptive histologic subtype with frequent clinically undetected tumor extension. 61
8607634 1996

Variations for Micronodular Basal Cell Carcinoma

Cosmic variations for Micronodular Basal Cell Carcinoma:

9 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510986 ZNF276 skin,NS,carcinoma,basal cell carcinoma c.*940C>T p.? 16:89739186-89739186 3
2 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
3 COSM87274302 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
4 COSM87270496 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
5 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
6 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
7 COSM87274307 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
8 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
9 COSM87273325 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
10 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
11 COSM87296537 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
12 COSM102023150 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7526C>T p.? 16:72958491-72958491 3
13 COSM102023155 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7920G>A p.? 16:72958885-72958885 3
14 COSM102019420 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8105C>T p.S2702F 16:72787429-72787429 3
15 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
16 COSM102023144 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.3083G>A p.G1028E 16:72796857-72796857 3
17 COSM102047764 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8308G>A p.D2770N 16:72787226-72787226 3
18 COSM87286441 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
19 COSM102036925 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7190C>T p.? 16:72958155-72958155 3
20 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
21 COSM102022243 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7097C>T p.? 16:72958062-72958062 3
22 COSM87274293 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
23 COSM104882801 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
24 COSM104236272 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
25 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
26 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
27 COSM101179498 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1913C>T p.S638F 16:2071897-2071897 3
28 COSM150324396 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
29 COSM101191558 TSC2 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.P241L 16:2058767-2058767 3
30 COSM147706701 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
31 COSM150353664 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
32 COSM151748023 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
33 COSM150576157 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
34 COSM149802478 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
35 COSM148980439 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
36 COSM90415129 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
37 COSM149800636 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
38 COSM148991757 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
39 COSM151753165 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
40 COSM151513825 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
41 COSM151371066 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
42 COSM148982237 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
43 COSM136628294 TSC2 skin,NS,carcinoma,basal cell carcinoma c.902C>T p.P301L 16:2058767-2058767 3
44 COSM110103971 TSC2 skin,NS,carcinoma,basal cell carcinoma c.568T>A p.C190S 16:2056674-2056674 3
45 COSM150583851 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
46 COSM102616914 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
47 COSM136618116 TSC2 skin,NS,carcinoma,basal cell carcinoma c.712T>A p.C238S 16:2056674-2056674 3
48 COSM110102044 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1949C>T p.S650F 16:2071897-2071897 3
49 COSM150574866 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
50 COSM102629996 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3

Expression for Micronodular Basal Cell Carcinoma

Search GEO for disease gene expression data for Micronodular Basal Cell Carcinoma.

Pathways for Micronodular Basal Cell Carcinoma

Pathways related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 KRT5 KRT15 KRT14
2 10.67 TLR7 MME EPCAM

GO Terms for Micronodular Basal Cell Carcinoma

Cellular components related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT5 KRT15 KRT14

Biological processes related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.54 KRT5 KRT15 KRT14
2 cytoskeleton organization GO:0007010 9.5 SOX9 KRT5 KRT15
3 negative regulation of osteoblast differentiation GO:0045668 9.46 SOX9 PTCH1
4 branching involved in ureteric bud morphogenesis GO:0001658 9.43 SOX9 PTCH1
5 mammary gland development GO:0030879 9.4 SOX9 PTCH1
6 prostate gland development GO:0030850 9.26 SOX9 PTCH1
7 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
8 cornification GO:0070268 9.13 KRT5 KRT15 KRT14
9 epidermis development GO:0008544 8.92 PTCH1 KRT5 KRT15 KRT14

Molecular functions related to Micronodular Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT5 KRT15
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT5 KRT15 KRT14

Sources for Micronodular Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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