Microscopic Colitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MCR191 MIFTS: 48	Microscopic Colitis Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Microscopic Colitis

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis ¹² ¹⁵ ¹⁷

Colitis, Microscopic ⁴⁵ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060182

MeSH ⁴⁵ D046728

NCIt ⁵¹ C38504

ICD10 ³⁴ K52.83

EFO ¹⁷ EFO_1001295

UMLS ⁷⁴ C0400821

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Summaries for Microscopic Colitis

Disease Ontology : ¹² A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to lymphocytic colitis and colitis. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are IL-2 Pathway and Th17 cell differentiation. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁷ Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

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Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)

#	Related Disease	Score	Top Affiliating Genes
1	lymphocytic colitis	32.4	ATP12A ATP4A
2	colitis	31.5	IFNG IL4 TNF
3	inflammatory bowel disease	29.9	IFNG IL4 TNF
4	collagenous colitis	12.2
5	diarrhea	10.5
6	alveolar echinococcosis	10.4	HLA-DRB1 TNF
7	oligoarticular juvenile idiopathic arthritis	10.4	HLA-DRB1 TNF
8	beryllium disease	10.4	HLA-DRB1 TNF
9	alexithymia	10.4	IL4 SLC6A4
10	acute salpingitis	10.4	LYZ TNF
11	microscopic polyangiitis	10.4	HLA-DRB1 TNF
12	tuberculous meningitis	10.4	LYZ TNF
13	tropical endomyocardial fibrosis	10.4	IL4 TNF
14	endomyocardial fibrosis	10.4	IL4 TNF
15	tungiasis	10.4	IL4 TNF
16	hypersensitivity vasculitis	10.4	CD79A HLA-DRB1
17	uveoparotid fever	10.4	LYZ TNF
18	hypersensitivity reaction type iii disease	10.3	CD79A TNF
19	pustulosis palmaris et plantaris	10.3	CD79A TNF
20	vulvovaginal candidiasis	10.3	CD79A IL4
21	actinic prurigo	10.3	HLA-DRB1 TNF
22	ulcerative stomatitis	10.3	CD79A LYZ
23	renal tuberculosis	10.3	CD79A LYZ
24	opisthorchiasis	10.3	IL4 TNF
25	sympathetic ophthalmia	10.3	HLA-DRB1 TNF
26	nontuberculous mycobacterial lung disease	10.3	HLA-DRB1 TNF
27	cow milk allergy	10.3	CD79A TNF
28	histoplasmosis	10.3	HLA-DRB1 IFNG
29	peanut allergy	10.3	HLA-DRB1 IFNG
30	chronic inflammatory demyelinating polyradiculoneuropathy	10.3	HLA-DRB1 IFNG
31	erythema multiforme	10.3	IFNG TNF
32	cytomegalovirus retinitis	10.3	IFNG TNF
33	pleural tuberculosis	10.3	IFNG TNF
34	spotted fever	10.3	IFNG TNF
35	posterior uveitis	10.3	IFNG TNF
36	intermediate uveitis	10.3	IFNG TNF
37	irritable bowel syndrome	10.3
38	congenital hypogammaglobulinemia	10.2	CD79A IL4
39	tuberculous peritonitis	10.2	IFNG TNF
40	autoimmune gastritis	10.2	IL4 TNF
41	buruli ulcer	10.2	IFNG IL4
42	chronic pulmonary heart disease	10.2	SLC6A4 TNF
43	rheumatic heart disease	10.2	HLA-DRB1 IL4 TNF
44	urinary schistosomiasis	10.2	IFNG IL4
45	folliculitis	10.2	IFNG IL4
46	periodic fever, familial, autosomal dominant	10.2	LYZ TNF
47	hyper ige syndrome	10.2	IFNG IL4
48	toxic oil syndrome	10.2	IFNG IL4
49	rubella	10.2	HLA-DRB1 IL4 TNF
50	rheumatoid vasculitis	10.2	HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Microscopic Colitis:

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Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

²⁷ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.47	IL4
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.47	CD79A
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.47	SLC6A4
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.47	CD79A
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	9.47	IL4
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.47	SLC6A4
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	9.47	SLC6A4
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.47	IL4
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.47	CD79A
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	9.47	CD79A IL4 SLC6A4
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.47	CD79A
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-90	9.47	SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.02	ATP12A ATP4A CD79A IFNG IL4 LYZ
2	digestive/alimentary	MP:0005381	9.98	ATP12A ATP4A IFNG IL4 LYZ PTEN
3	endocrine/exocrine gland	MP:0005379	9.95	ATP4A IFNG IL4 LYZ PTEN SLC6A4
4	integument	MP:0010771	9.8	IFNG IL4 LYZ PTEN SLC6A4 TNF
5	liver/biliary system	MP:0005370	9.73	CD79A IFNG IL4 LYZ PTEN TNF
6	neoplasm	MP:0002006	9.63	ATP4A CD79A IFNG LYZ PTEN TNF
7	normal	MP:0002873	9.43	CD79A IFNG IL4 LYZ PTEN SLC6A4
8	renal/urinary system	MP:0005367	9.1	ATP12A CD79A IFNG IL4 LYZ PTEN

Sources

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Budesonide

Approved

Phase 3,Phase 2,Not Applicable

51333-22-3

5281004 63006

Synonyms:

(11b,16a)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde

(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde

(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione

16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

51333-22-3

AC1L1DQE

AC1L1Y6Y

AC1L22VC

AC1MHWI7

AC-4697

B 7777

B7777_SIGMA

Bidien

Bio-0010

BPBio1_000523

BRD-A34299591-001-03-4

BRD-A82238138-001-01-7

BSPBio_000475

BSPBio_002160

Budecort Inhaler

Budenofalk

Budeson

Budesónida

budesonide

Budesonide

Budesonide (JAN/USAN/INN)

Budesonide [USAN:INN:BAN:JAN]

Budesonide Easyhaler

Budesonide MMX

Budesonide, (R)-isomer

Budesonide, (S)-isomer

Budesonido

Budesonido [INN-Spanish]

Budesonidum

Budesonidum [INN-Latin]

Budiair

Budicort

C25H34O6

CCRIS 5230

CHEBI:3207

CHEBI:656601

CHEMBL1370

CID2462

CID3033890

CID40000

CID5281004

CID63006

Cortivent

CPD000058337

D00246

DB01222

Desowen

Dexbudesonide

Dexbudesonide [INN]

DivK1c_000475

EINECS 257-139-7

EINECS 257-160-1

EINECS 257-161-7

Entocort

Entocort EC

Entocort EC (TN)

EU-0100174

Giona Easyhaler

HMS1569H17

HMS1921I22

HMS2094I13

HMS501H17

Horacort

IDI1_000475

Inflammide

KBio1_000475

KBio3_001660

KBioGR_001361

Lopac0_000174

LS-187734

LS-7235

MAP-0010

Micronyl

Miflonide

MLS000028507

MLS001077323

MLS002207112

MolPort-002-529-265

MolPort-003-666-332

MolPort-003-986-909

NCGC00015165-03

NCGC00021318-03

NCGC00021318-06

NCGC00089747-02

NCGC00089747-03

NCGC00089747-04

NCGC00178789-01

NINDS_000475

Noex

Preferid

Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Prestwick_840

Prestwick0_000518

Prestwick1_000518

Prestwick2_000518

Prestwick3_000518

Pulmaxan

Pulmaxan turbohaler

Pulmicort

Pulmicort (TN)

Pulmicort Flexhaler

Pulmicort Nebuamp

Pulmicort Respules

Pulmicort Topinasal

Pulmicort turbuhaler

Pulmicort Turbuhaler

Respules

Rhinocort

Rhinocort alpha

Rhinocort Aqua

Rhinocort Turbuhaler

Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide

Rhinosol

S 1320

S1286_Selleck

S-1320

SAM002699898

SMR000058337

SPBio_000586

SPBio_002396

SPECTRUM1500813

Spectrum2_000623

Spectrum3_000620

Spectrum4_000821

Spectrum5_001738

Spirocort

ST51039033

TL8003397

Tridesilon

UDB

UNII-168L5HT37P

UNII-2HI1006KPH

UNII-Q3OKS62Q6X

Unit dose budesonide

ZINC03938751

ZINC04097286

Rifaximin

Approved, Investigational

Phase 3

80621-81-4

46783403 6436173

Synonyms:

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate

4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV

80621-81-4

88747-56-2

AC-19112

alpha-0817185

Bio-0556

BRN 3584528

C43H51N3O11

CHEMBL1617

D02554

DB01220

Fatroximin

Flonorm

L 105

L 105 (Ansamacrolide antibiotic)

L 105SV

Lormyx

LS-178059

LS-64147

Lumenax

MLS000759430

Normix

Redactiv

RedActiv

Rifacol

Rifamixin

Rifamycin L 105

Rifamycin L 105SV

Rifaxidin

Rifaximin

Rifaximin (USAN/INN)

Rifaximin [USAN:INN]

Rifaximina

Rifaximina [Spanish]

Rifaximine

Rifaximine [French]

Rifaximinum

Rifaximinum [Latin]

Rifaximinun

Rifaxin

Ritacol

S1790_Selleck

SMR000466324

Spiraxin

UNII-L36O5T016N

Xifaxan

Xifaxan, Rifacol, Fatroximin, Rifaximin

Xifaxsan

Xifaxsan (TN)

glucocorticoids

Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 3,Phase 2,Not Applicable

Peripheral Nervous System Agents

Phase 3,Phase 2,Not Applicable

Hormones

Phase 3,Phase 2,Not Applicable

Anti-Inflammatory Agents

Phase 3,Phase 2,Not Applicable

Anti-Asthmatic Agents

Phase 3,Phase 2,Not Applicable

Respiratory System Agents

Phase 3,Phase 2,Not Applicable

Bronchodilator Agents

Phase 3,Phase 2,Not Applicable

Autonomic Agents

Phase 3,Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2,Not Applicable

Mesalamine

Phase 2, Phase 3,Phase 3

89-57-6

Analgesics

Phase 2, Phase 3,Phase 3

Analgesics, Non-Narcotic

Phase 2, Phase 3,Phase 3

Antirheumatic Agents

Phase 2, Phase 3,Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 2, Phase 3,Phase 3

Anti-Bacterial Agents

Phase 3

Gastrointestinal Agents

Phase 3,Not Applicable

Anti-Infective Agents

Phase 3

Pharmaceutical Solutions

Not Applicable

Cola

Not Applicable

Antibodies

Not Applicable

Immunoglobulins

Not Applicable

Antacids

Not Applicable

Anti-Ulcer Agents

Not Applicable

Bismuth

Not Applicable

7440-69-9

105143 16682734

Synonyms:

17034_FLUKA

24267-48-9

25243-76-9

264008_ALDRICH

265462_ALDRICH

265470_ALDRICH

452386_ALDRICH

556130_ALDRICH

7440-69-9

83Bi

95372_ALDRICH

95372_FLUKA

95375_FLUKA

AC1NSDYX

AC1O4PN8

AR-1I0647

Bi(3+)

Bismut

bismuth

Bismuth standard for AAS

Bismuth standard for ICP

Bismuth(III) cation

Bismuth(III) nitrate solution

BISMUTH, 99.95%

BISMUTH, 99.999%

Bismuth, elemental

Bismuth-209

bismuto

Bisumth(3+) ion

C15471

CHEBI:33301

CID5359367

EINECS 231-177-4

HSDB 2078

LS-44708

LTBB002773

MolPort-003-925-759

Wismut

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	Long-Term Treatment of Collagenous Colitis With Budesonide	Unknown status	NCT00139165	Phase 3	Budesonide
2	Trial of Mesalamine for the Treatment of Active Microscopic Colitis	Completed	NCT00952952	Phase 2, Phase 3	Mesalamine
3	Budesonide Treatment for Lymphocytic Colitis	Completed	NCT00180050	Phase 3	Budesonide
4	Budesonide for Maintenance Treatment of Collagenous Colitis	Completed	NCT00180076	Phase 3	Budesonide
5	SOIBD Collagenous Colitis Maintenance Study	Completed	NCT01278082	Phase 3	Budesonide;Placebo
6	Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis	Completed	NCT01209208	Phase 3	Budesonide;Mesalamine
7	Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis	Completed	NCT00450086	Phase 3	Budesonide;Mesalazine;Placebo
8	Budesonide for Induction of Remission in Incomplete Microscopic Colitis	Recruiting	NCT02142634	Phase 3	Budesonide granules 9 mg;Placebo granules
9	Rifaximin-treatment of Collagenous Colitis	Not yet recruiting	NCT03658993	Phase 3	Rifaximin 550 MG
10	Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis	Terminated	NCT00217022	Phase 2, Phase 3	Budesonide
11	Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis	Unknown status	NCT01504048	Not Applicable
12	Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS)	Unknown status	NCT01787253
13	Case-Control Study to Identify Risk Factors for Microscopic Colitis	Completed	NCT01928667
14	Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis	Completed	NCT02303132	Not Applicable
15	Risk Factors for Microscopic Colitis	Recruiting	NCT02699333
16	Identification/Characterization of Changes in Microscopic Colitis	Recruiting	NCT03063957
17	Interest of Pan-capsule in Symptomatic Patients Suspected of Irritable Bowel Syndrome Requiring Colonoscopy	Recruiting	NCT03806959	Not Applicable
18	Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy	Recruiting	NCT02284802	Not Applicable
19	Fecal Microbiota Transplantation for C Diff Infection	Recruiting	NCT01905709	Not Applicable
20	Faecal Microbiota Transplantation in Patients With Microscopic Colitis	Enrolling by invitation	NCT03275467	Not Applicable
21	FMT in Inflammatory Bowel Disease	Not yet recruiting	NCT03477032
22	Treatment of Microscopic Colitis	Terminated	NCT00184171	Not Applicable	Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

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Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

⁴²

Colon, Bone, Lung, Skin, Heart, T Cells, Small Intestine

Sources

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 380)

#	Title	Authors	Year
1	Correction: Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women Without Celiac Disease: A Prospective Cohort Study. ( 31082842 )	Liu PH...Khalili H	2019
2	Microscopic colitis: Struggling with an invisible, disabling disease. ( 31090966 )	Lesnovska KP...Hjortswang H	2019
3	An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide. ( 31009268 )	Rindom Krogsgaard L...Wildt S	2019
4	Topical beclometasone dipropionate in the management of immune checkpoint inhibitor-induced microscopic colitis. ( 30948391 )	Ibraheim H...Powell N	2019
5	A nationwide cohort study of the incidence of microscopic colitis in Sweden. ( 30983010 )	Bergman D...Ludvigsson JF	2019
6	Microscopic colitis: pathophysiology and clinical management. ( 30860066 )	Miehlke S...M?nch A	2019
7	Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis. ( 30869794 )	Jaruvongvanich V...Ungprasert P	2019
8	Management of microscopic colitis: challenges and solutions. ( 30881078 )	Shor J...Marshall C	2019
9	Vedolizumab-Induced Remission in 3 Patients With Refractory Microscopic Colitis: A Tertiary Care Center Case Series. ( 30889247 )	Jennings JJ...Charabaty A	2019
10	Relative risk of microscopic colitis in dermatomyositis. ( 30910660 )	Pearson DR...Werth VP	2019
11	Validating microscopic colitis (MC) in Swedish pathology registers. ( 30600733 )	Svensson M...Ludvigsson JF	2019
12	Cancer risk in microscopic colitis: a retrospective cohort study. ( 30611218 )	Levy A...Ananthakrishnan AN	2019
13	Microscopic colitis: a narrative review with clinical approach. ( 30486642 )	Mosso E...Pellicano R	2019
14	Proinflammatory Sulfur-Reducing Bacteria Are More Abundant in Colonic Biopsies of Patients with Microscopic Colitis Compared to Healthy Controls. ( 30324555 )	Millien V...Shah R	2019
15	Vedolizumab in Refractory Microscopic Colitis: An International Case Series. ( 30329034 )	Rivi?re P...Van Assche G	2019
16	Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity? ( 30169584 )	Choi K...Wang Y	2019
17	Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. ( 30181535 )	Liu PH...Khalili H	2019
18	Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis. ( 30529732 )	Liu PH...Khalili H	2018
19	Do Sex Hormones Cause, or Are They Only Associated With, Microscopic Colitis? ( 30419213 )	Pabla B...Ness RM	2018
20	Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated. ( 30318685 )	Tao P...Wang S	2018
21	Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated-author's reply. ( 30318693 )	Bonderup OK	2018
22	Microscopic colitis: Diarrhoea or constipation. ( 30323375 )	Iqbal U...Anwar H	2018
23	Antidepressants and its relationship with microscopic colitis. ( 30338777 )	Hern?ndez-Huerta D...Mesonero-Gismero F	2018
24	Fatigue and its associated factors in microscopic colitis. ( 30228831 )	Kane JS...Ford AC	2018
25	Editorial: proton pump inhibitors (PPIs) and microscopic colitis. ( 30281829 )	Krol R...van Oijen MGH	2018
26	Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. ( 30144433 )	Burke KE...Khalili H	2018
27	High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. ( 29977339 )	Kane JS...Ford AC	2018
28	Microscopic Colitis: A Rare Cause of Pseudomembranes. ( 29981436 )	Schenck RJ...Pezhouh MK	2018
29	Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. ( 30039564 )	Bonderup OK...Hallas J	2018
30	Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. ( 29852792 )	Davidson S...Munck LK	2018
31	Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. ( 29742325 )	Moore M...Loughrey MB	2018
32	Pembrolizumab-Induced Microscopic Colitis. ( 29610496 )	Ahmed M...Francis G	2018
33	Microscopic colitis-microbiome, barrier function and associated diseases. ( 29610731 )	van Hemert S...Marlicz W	2018
34	The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. ( 29610757 )	Engel PJH...Kristensson M	2018
35	Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. ( 29535059 )	Sonnenberg A...Genta RM	2018
36	Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. ( 29546806 )	Wickbom A...Swedish Organisation for the Study of Inflammatory Bowel Disease (SOIBD)	2018
37	Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease. ( 29603881 )	Sonnenberg A...Genta RM	2018
38	Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )	Holz K...Margolis RL	2018
39	Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis. ( 29457048 )	Torres J...Borralho P	2018
40	Risk of osteoporosis in microscopic colitis. ( 29460653 )	Wildt S...Hitz MF	2018
41	Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. ( 29370359 )	Burke KE...Khalili H	2018
42	Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. ( 29204743 )	Nor?n E...S?derman J	2018
43	Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )	Gentile N...Yen EF	2018
44	Development of a Microscopic Colitis Disease Activity Index: a prospective cohort study. ( 27965284 )	Cotter TG...Pardi DS	2018
45	Symptomatic Microscopic Colitis Atop Quiescent Inflammatory Bowel Disease: A Case Series. ( 29299484 )	Megna B...Caldera F	2017
46	Medical Treatment for Microscopic Colitis: A Community Hospital's Experience. ( 29317939 )	Haidar A...Cutler A	2017
47	Case report: Pentoxifylline treatment in microscopic colitis. ( 29145246 )	Cotter TG...Pardi DS	2017
48	Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )	Boland K...Nguyen GC	2017
49	Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis? ( 29078077 )	Rizzo AG...Cottone M	2017
50	Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )	Marlicz W...Koulaouzidis A	2017

Sources

Genes for Microscopic Colitis

Genes related to Microscopic Colitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNF	Tumor Necrosis Factor	Protein Coding	21.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	19.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	16.93	GeneCards inferred via : Publications (show sections)
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	16.83	DISEASES inferred ¹⁵
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	16.83	DISEASES inferred ¹⁵
6	IL4	Interleukin 4	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
7	LYZ	Lysozyme	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
8	PTEN	Phosphatase And Tensin Homolog	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
9	CD79A	CD79a Molecule	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
10	MAGI1	Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
11	IFNG	Interferon Gamma	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)

Sources

Variations for Microscopic Colitis

Sources

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Sources

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	IL-2 Pathway ⁶⁵ Show member pathways ErbB Family Pathway ⁶⁵ ErbB2-ErbB3 Heterodimers ⁶⁵ ErbB4 Pathway ⁶⁵ Growth Hormone Signaling ⁶⁵ HMGB1 Pathway ⁶⁵ IL-4 Pathway ⁶⁵ LPS Stimulated MAPK Signaling ⁶⁵ PACAP Signaling ⁶⁵ PI3K Signaling in B-Lymphocyte ⁶⁵ Prolactin Signaling ⁶⁵ Thrombopoietin Pathway ⁶⁵ TREM1 Pathway ⁶⁵ UVC-Induced MAPK Signaling ⁶⁵	12.83	CD79A HLA-DRB1 IFNG IL4 PTEN TNF
2	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.38	HLA-DRB1 IFNG IL4 TNF
3	Immune response Fc epsilon RI pathway ²³ Show member pathways Fc epsilon RI signaling pathway ³⁸ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²³ VEGF signaling pathway ³⁸	12.36	CD79A IL4 PTEN TNF
4	NF-kappaB Signaling ⁴	12.31	CD79A IFNG IL4 TNF
5	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.21	CD79A HLA-DRB1 IFNG IL4 TNF
6	Tuberculosis ³⁸	12.01	HLA-DRB1 IFNG TNF
7	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.97	IFNG IL4 TNF
8	Toxoplasmosis ³⁸ Show member pathways Leishmaniasis ³⁸	11.89	HLA-DRB1 IFNG IL4 TNF
9	Microglia Activation During Neuroinflammation: Overview ⁶⁶ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁶	11.84	IFNG IL4 TNF
10	Spinal Cord Injury ¹	11.81	IFNG IL4 TNF
11	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.78	HLA-DRB1 IFNG IL4
12	Hematopoietic cell lineage ³⁸	11.67	HLA-DRB1 IL4 TNF
13	Rheumatoid arthritis ³⁸	11.61	HLA-DRB1 IFNG TNF
14	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.54	IFNG IL4 TNF
15	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.49	IFNG IL4 TNF
16	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁶	11.43	IFNG IL4 TNF
17	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.32	CD79A IFNG IL4 TNF
18	IL12 signaling mediated by STAT4 ¹	11.05	HLA-DRB1 IFNG
19	OX40 Pathway ⁶⁵	11.01	IFNG IL4
20	Development and heterogeneity of the ILC family ¹	10.84	IFNG IL4 TNF
21	Cytokines and Inflammatory Response ¹	10.39	HLA-DRB1 IFNG IL4 TNF

Sources

GO Terms for Microscopic Colitis

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.83	HLA-DRB1 IFNG IL4 TNF
2	ATP hydrolysis coupled proton transport	GO:0015991	9.56	ATP12A ATP4A
3	B cell activation	GO:0042113	9.55	CD79A IL4
4	positive regulation of protein complex assembly	GO:0031334	9.54	IFNG TNF
5	brain morphogenesis	GO:0048854	9.51	PTEN SLC6A4
6	positive regulation of osteoclast differentiation	GO:0045672	9.49	IFNG TNF
7	cellular sodium ion homeostasis	GO:0006883	9.48	ATP12A ATP4A
8	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.46	IFNG TNF
9	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.43	ATP12A ATP4A
10	response to organic substance	GO:0010033	9.43	PTEN SLC6A4 TNF
11	cellular potassium ion homeostasis	GO:0030007	9.4	ATP12A ATP4A
12	sodium ion export across plasma membrane	GO:0036376	9.37	ATP12A ATP4A
13	positive regulation of gene expression	GO:0010628	9.35	IFNG IL4 PTEN SLC6A4 TNF
14	negative regulation of organ growth	GO:0046621	9.32	PTEN SLC6A4
15	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.16	IFNG TNF
16	positive regulation of vitamin D biosynthetic process	GO:0060557	8.62	IFNG TNF

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	8.96	ATP12A ATP4A
2	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP12A ATP4A

Sources

Sources for Microscopic Colitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia