MCID: MCR191
MIFTS: 48

Microscopic Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Microscopic Colitis

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 15 17
Colitis, Microscopic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060182
MeSH 45 D046728
NCIt 51 C38504
ICD10 34 K52.83
UMLS 74 C0400821

Summaries for Microscopic Colitis

Disease Ontology : 12 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to lymphocytic colitis and colitis. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are IL-2 Pathway and Th17 cell differentiation. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 32.4 ATP12A ATP4A
2 colitis 31.5 IFNG IL4 TNF
3 inflammatory bowel disease 29.9 IFNG IL4 TNF
4 collagenous colitis 12.2
5 diarrhea 10.5
6 alveolar echinococcosis 10.4 HLA-DRB1 TNF
7 oligoarticular juvenile idiopathic arthritis 10.4 HLA-DRB1 TNF
8 beryllium disease 10.4 HLA-DRB1 TNF
9 alexithymia 10.4 IL4 SLC6A4
10 acute salpingitis 10.4 LYZ TNF
11 microscopic polyangiitis 10.4 HLA-DRB1 TNF
12 tuberculous meningitis 10.4 LYZ TNF
13 tropical endomyocardial fibrosis 10.4 IL4 TNF
14 endomyocardial fibrosis 10.4 IL4 TNF
15 tungiasis 10.4 IL4 TNF
16 hypersensitivity vasculitis 10.4 CD79A HLA-DRB1
17 uveoparotid fever 10.4 LYZ TNF
18 hypersensitivity reaction type iii disease 10.3 CD79A TNF
19 pustulosis palmaris et plantaris 10.3 CD79A TNF
20 vulvovaginal candidiasis 10.3 CD79A IL4
21 actinic prurigo 10.3 HLA-DRB1 TNF
22 ulcerative stomatitis 10.3 CD79A LYZ
23 renal tuberculosis 10.3 CD79A LYZ
24 opisthorchiasis 10.3 IL4 TNF
25 sympathetic ophthalmia 10.3 HLA-DRB1 TNF
26 nontuberculous mycobacterial lung disease 10.3 HLA-DRB1 TNF
27 cow milk allergy 10.3 CD79A TNF
28 histoplasmosis 10.3 HLA-DRB1 IFNG
29 peanut allergy 10.3 HLA-DRB1 IFNG
30 chronic inflammatory demyelinating polyradiculoneuropathy 10.3 HLA-DRB1 IFNG
31 erythema multiforme 10.3 IFNG TNF
32 cytomegalovirus retinitis 10.3 IFNG TNF
33 pleural tuberculosis 10.3 IFNG TNF
34 spotted fever 10.3 IFNG TNF
35 posterior uveitis 10.3 IFNG TNF
36 intermediate uveitis 10.3 IFNG TNF
37 irritable bowel syndrome 10.3
38 congenital hypogammaglobulinemia 10.2 CD79A IL4
39 tuberculous peritonitis 10.2 IFNG TNF
40 autoimmune gastritis 10.2 IL4 TNF
41 buruli ulcer 10.2 IFNG IL4
42 chronic pulmonary heart disease 10.2 SLC6A4 TNF
43 rheumatic heart disease 10.2 HLA-DRB1 IL4 TNF
44 urinary schistosomiasis 10.2 IFNG IL4
45 folliculitis 10.2 IFNG IL4
46 periodic fever, familial, autosomal dominant 10.2 LYZ TNF
47 hyper ige syndrome 10.2 IFNG IL4
48 toxic oil syndrome 10.2 IFNG IL4
49 rubella 10.2 HLA-DRB1 IL4 TNF
50 rheumatoid vasculitis 10.2 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis

Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 IL4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.47 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.47 SLC6A4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.47 CD79A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.47 IL4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.47 SLC6A4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.47 SLC6A4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.47 IL4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 CD79A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.47 CD79A IL4 SLC6A4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 CD79A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.47 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 ATP12A ATP4A CD79A IFNG IL4 LYZ
2 digestive/alimentary MP:0005381 9.98 ATP12A ATP4A IFNG IL4 LYZ PTEN
3 endocrine/exocrine gland MP:0005379 9.95 ATP4A IFNG IL4 LYZ PTEN SLC6A4
4 integument MP:0010771 9.8 IFNG IL4 LYZ PTEN SLC6A4 TNF
5 liver/biliary system MP:0005370 9.73 CD79A IFNG IL4 LYZ PTEN TNF
6 neoplasm MP:0002006 9.63 ATP4A CD79A IFNG LYZ PTEN TNF
7 normal MP:0002873 9.43 CD79A IFNG IL4 LYZ PTEN SLC6A4
8 renal/urinary system MP:0005367 9.1 ATP12A CD79A IFNG IL4 LYZ PTEN

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Phase 2,Not Applicable 51333-22-3 5281004 63006
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 46783403 6436173
3 glucocorticoids Phase 3,Phase 2,Not Applicable
4 Hormone Antagonists Phase 3,Phase 2,Not Applicable
5 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
6 Hormones Phase 3,Phase 2,Not Applicable
7 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
8 Anti-Asthmatic Agents Phase 3,Phase 2,Not Applicable
9 Respiratory System Agents Phase 3,Phase 2,Not Applicable
10 Bronchodilator Agents Phase 3,Phase 2,Not Applicable
11 Autonomic Agents Phase 3,Phase 2,Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
13 Mesalamine Phase 2, Phase 3,Phase 3 89-57-6
14 Analgesics Phase 2, Phase 3,Phase 3
15 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
16 Antirheumatic Agents Phase 2, Phase 3,Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
18 Anti-Bacterial Agents Phase 3
19 Gastrointestinal Agents Phase 3,Not Applicable
20 Anti-Infective Agents Phase 3
21 Pharmaceutical Solutions Not Applicable
22 Cola Not Applicable
23 Antibodies Not Applicable
24 Immunoglobulins Not Applicable
25 Antacids Not Applicable
26 Anti-Ulcer Agents Not Applicable
27
Bismuth Not Applicable 7440-69-9 105143 16682734

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
2 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3 Mesalamine
3 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
4 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
5 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3 Budesonide;Placebo
6 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Completed NCT01209208 Phase 3 Budesonide;Mesalamine
7 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
8 Budesonide for Induction of Remission in Incomplete Microscopic Colitis Recruiting NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
9 Rifaximin-treatment of Collagenous Colitis Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
10 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
11 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
12 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
13 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
14 Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis Completed NCT02303132 Not Applicable
15 Risk Factors for Microscopic Colitis Recruiting NCT02699333
16 Identification/Characterization of Changes in Microscopic Colitis Recruiting NCT03063957
17 Interest of Pan-capsule in Symptomatic Patients Suspected of Irritable Bowel Syndrome Requiring Colonoscopy Recruiting NCT03806959 Not Applicable
18 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Recruiting NCT02284802 Not Applicable
19 Fecal Microbiota Transplantation for C Diff Infection Recruiting NCT01905709 Not Applicable
20 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Enrolling by invitation NCT03275467 Not Applicable
21 FMT in Inflammatory Bowel Disease Not yet recruiting NCT03477032
22 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

Genetic Tests for Microscopic Colitis

Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

42
Colon, Bone, Lung, Skin, Heart, T Cells, Small Intestine

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 380)
# Title Authors Year
1
Correction: Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women Without Celiac Disease: A Prospective Cohort Study. ( 31082842 )
2019
2
Microscopic colitis: Struggling with an invisible, disabling disease. ( 31090966 )
2019
3
An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide. ( 31009268 )
2019
4
Topical beclometasone dipropionate in the management of immune checkpoint inhibitor-induced microscopic colitis. ( 30948391 )
2019
5
A nationwide cohort study of the incidence of microscopic colitis in Sweden. ( 30983010 )
2019
6
Microscopic colitis: pathophysiology and clinical management. ( 30860066 )
2019
7
Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis. ( 30869794 )
2019
8
Management of microscopic colitis: challenges and solutions. ( 30881078 )
2019
9
Vedolizumab-Induced Remission in 3 Patients With Refractory Microscopic Colitis: A Tertiary Care Center Case Series. ( 30889247 )
2019
10
Relative risk of microscopic colitis in dermatomyositis. ( 30910660 )
2019
11
Validating microscopic colitis (MC) in Swedish pathology registers. ( 30600733 )
2019
12
Cancer risk in microscopic colitis: a retrospective cohort study. ( 30611218 )
2019
13
Microscopic colitis: a narrative review with clinical approach. ( 30486642 )
2019
14
Proinflammatory Sulfur-Reducing Bacteria Are More Abundant in Colonic Biopsies of Patients with Microscopic Colitis Compared to Healthy Controls. ( 30324555 )
2019
15
Vedolizumab in Refractory Microscopic Colitis: An International Case Series. ( 30329034 )
2019
16
Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity? ( 30169584 )
2019
17
Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. ( 30181535 )
2019
18
Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis. ( 30529732 )
2018
19
Do Sex Hormones Cause, or Are They Only Associated With, Microscopic Colitis? ( 30419213 )
2018
20
Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated. ( 30318685 )
2018
21
Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated-author's reply. ( 30318693 )
2018
22
Microscopic colitis: Diarrhoea or constipation. ( 30323375 )
2018
23
Antidepressants and its relationship with microscopic colitis. ( 30338777 )
2018
24
Fatigue and its associated factors in microscopic colitis. ( 30228831 )
2018
25
Editorial: proton pump inhibitors (PPIs) and microscopic colitis. ( 30281829 )
2018
26
Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. ( 30144433 )
2018
27
High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. ( 29977339 )
2018
28
Microscopic Colitis: A Rare Cause of Pseudomembranes. ( 29981436 )
2018
29
Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. ( 30039564 )
2018
30
Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. ( 29852792 )
2018
31
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. ( 29742325 )
2018
32
Pembrolizumab-Induced Microscopic Colitis. ( 29610496 )
2018
33
Microscopic colitis-microbiome, barrier function and associated diseases. ( 29610731 )
2018
34
The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. ( 29610757 )
2018
35
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. ( 29535059 )
2018
36
Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. ( 29546806 )
2018
37
Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease. ( 29603881 )
2018
38
Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )
2018
39
Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis. ( 29457048 )
2018
40
Risk of osteoporosis in microscopic colitis. ( 29460653 )
2018
41
Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. ( 29370359 )
2018
42
Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. ( 29204743 )
2018
43
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )
2018
44
Development of a Microscopic Colitis Disease Activity Index: a prospective cohort study. ( 27965284 )
2018
45
Symptomatic Microscopic Colitis Atop Quiescent Inflammatory Bowel Disease: A Case Series. ( 29299484 )
2017
46
Medical Treatment for Microscopic Colitis: A Community Hospital's Experience. ( 29317939 )
2017
47
Case report: Pentoxifylline treatment in microscopic colitis. ( 29145246 )
2017
48
Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )
2017
49
Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis? ( 29078077 )
2017
50
Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )
2017

Variations for Microscopic Colitis

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 CD79A HLA-DRB1 IFNG IL4 PTEN TNF
2
Show member pathways
12.38 HLA-DRB1 IFNG IL4 TNF
3
Show member pathways
12.36 CD79A IL4 PTEN TNF
4 12.31 CD79A IFNG IL4 TNF
5
Show member pathways
12.21 CD79A HLA-DRB1 IFNG IL4 TNF
6 12.01 HLA-DRB1 IFNG TNF
7
Show member pathways
11.97 IFNG IL4 TNF
8
Show member pathways
11.89 HLA-DRB1 IFNG IL4 TNF
9
Show member pathways
11.84 IFNG IL4 TNF
10 11.81 IFNG IL4 TNF
11
Show member pathways
11.78 HLA-DRB1 IFNG IL4
12 11.67 HLA-DRB1 IL4 TNF
13 11.61 HLA-DRB1 IFNG TNF
14 11.54 IFNG IL4 TNF
15
Show member pathways
11.49 IFNG IL4 TNF
16 11.43 IFNG IL4 TNF
17 11.32 CD79A IFNG IL4 TNF
18 11.05 HLA-DRB1 IFNG
19 11.01 IFNG IL4
20 10.84 IFNG IL4 TNF
21 10.39 HLA-DRB1 IFNG IL4 TNF

GO Terms for Microscopic Colitis

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 HLA-DRB1 IFNG IL4 TNF
2 ATP hydrolysis coupled proton transport GO:0015991 9.56 ATP12A ATP4A
3 B cell activation GO:0042113 9.55 CD79A IL4
4 positive regulation of protein complex assembly GO:0031334 9.54 IFNG TNF
5 brain morphogenesis GO:0048854 9.51 PTEN SLC6A4
6 positive regulation of osteoclast differentiation GO:0045672 9.49 IFNG TNF
7 cellular sodium ion homeostasis GO:0006883 9.48 ATP12A ATP4A
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG TNF
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP12A ATP4A
10 response to organic substance GO:0010033 9.43 PTEN SLC6A4 TNF
11 cellular potassium ion homeostasis GO:0030007 9.4 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.37 ATP12A ATP4A
13 positive regulation of gene expression GO:0010628 9.35 IFNG IL4 PTEN SLC6A4 TNF
14 negative regulation of organ growth GO:0046621 9.32 PTEN SLC6A4
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
16 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Microscopic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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