MCID: MCR191
MIFTS: 48

Microscopic Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Microscopic Colitis

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 15 17
Colitis, Microscopic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060182
MeSH 45 D046728
NCIt 51 C38504
ICD10 34 K52.83
UMLS 74 C0400821

Summaries for Microscopic Colitis

Disease Ontology : 12 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to lymphocytic colitis and colitis. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are IL-2 Pathway and Allograft rejection. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 32.3 ATP12A ATP4A
2 colitis 31.6 IL2 IL6 TNF
3 inflammatory bowel disease 30.4 IL2 IL6 TNF
4 ulcerative colitis 30.2 IL2 IL6 TNF
5 diabetes mellitus 28.9 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
6 collagenous colitis 12.2
7 sympathetic ophthalmia 10.4 HLA-DRB1 TNF
8 nontuberculous mycobacterial lung disease 10.4 HLA-DRB1 TNF
9 rheumatoid vasculitis 10.4 HLA-DRB1 TNF
10 chronic pulmonary heart disease 10.4 SLC6A4 TNF
11 rheumatoid arthritis, systemic juvenile 10.4 HLA-DRB1 IL6
12 cystic echinococcosis 10.4 HLA-DRB1 IL6
13 microscopic polyangiitis 10.4 HLA-DRB1 TNF
14 ischemic heart disease 10.4 IL6 TNF
15 autoimmune disease of eyes, ear, nose and throat 10.4 IL6 TNF
16 endometrial disease 10.4 IL6 TNF
17 meconium aspiration syndrome 10.4 IL6 TNF
18 listeriosis 10.4 IL6 TNF
19 louse-borne relapsing fever 10.4 IL6 TNF
20 poems syndrome 10.4 IL6 TNF
21 periapical periodontitis 10.4 IL6 TNF
22 stachybotrys chartarum 10.4 IL6 TNF
23 transverse myelitis 10.4 IL6 TNF
24 diarrhea 10.4
25 oral tuberculosis 10.4 IL2 TNF
26 hypersensitivity vasculitis 10.4 CD79A HLA-DRB1
27 primary effusion lymphoma 10.3 IL6 PTEN
28 orofacial granulomatosis 10.3 CD79A TNF
29 scorpion envenomation 10.3 IL6 TNF
30 capillary leak syndrome 10.3 IL2 IL6
31 necrotizing fasciitis 10.3 IL2 IL6
32 peanut allergy 10.3 HLA-DQB1 HLA-DRB1
33 leukomalacia 10.3 IL6 TNF
34 osteonecrosis of the jaw 10.3 HLA-DQB1 HLA-DRB1
35 berylliosis 10.3 HLA-DRB1 IL2
36 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
37 idiopathic bronchiectasis 10.3 HLA-DQB1 HLA-DRB1
38 sialadenitis 10.3 HLA-DQB1 TNF
39 autoimmune myocarditis 10.3 IL6 TNF
40 vulvovaginal candidiasis 10.3 CD79A IL2
41 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
42 critical limb ischemia 10.3 IL6 TNF
43 farmer's lung 10.3 IL2 TNF
44 juvenile ankylosing spondylitis 10.3 IL6 TNF
45 cardiogenic shock 10.3 IL6 TNF
46 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
47 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
48 mesangial proliferative glomerulonephritis 10.3 CD79A IL6
49 null-cell leukemia 10.3 IL6 TNF
50 retinitis pigmentosa 55 10.3 IL6 TNF

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis

Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 CD79A HLA-DQB1 SLC6A4
2 Decreased viability GR00381-A-3 9.28 CD79A HLA-DQB1 SLC6A4
3 Decreased viability GR00402-S-2 9.28 CD79A HLA-DQB1 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.95 ATP12A ATP4A HLA-DQB1 IL2 IL6 PTEN
2 hematopoietic system MP:0005397 9.92 ATP4A CD79A HLA-DQB1 IL2 IL6 MR1
3 endocrine/exocrine gland MP:0005379 9.91 ATP4A HLA-DQB1 IL2 IL6 PTEN SLC6A4
4 homeostasis/metabolism MP:0005376 9.91 ATP12A ATP4A CD79A HLA-DQB1 IL2 IL6
5 immune system MP:0005387 9.76 ATP4A CD79A HLA-DQB1 IL2 IL6 MR1
6 liver/biliary system MP:0005370 9.43 CD79A HLA-DQB1 IL2 IL6 PTEN TNF
7 neoplasm MP:0002006 9.1 ATP4A CD79A IL2 IL6 PTEN TNF

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Phase 2,Not Applicable 51333-22-3 63006 5281004
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173 46783403
3 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
4 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
5 Hormones Phase 3,Phase 2,Not Applicable
6 Anti-Asthmatic Agents Phase 3,Phase 2,Not Applicable
7 Autonomic Agents Phase 3,Phase 2,Not Applicable
8 Hormone Antagonists Phase 3,Phase 2,Not Applicable
9 Bronchodilator Agents Phase 3,Phase 2,Not Applicable
10 Respiratory System Agents Phase 3,Phase 2,Not Applicable
11 glucocorticoids Phase 3,Phase 2,Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
13 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
14 Antirheumatic Agents Phase 2, Phase 3,Phase 3
15 Analgesics Phase 2, Phase 3,Phase 3
16 Mesalamine Phase 2, Phase 3,Phase 3 89-57-6
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
18 Gastrointestinal Agents Phase 3,Not Applicable
19 Anti-Infective Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21 Cola Not Applicable
22 Pharmaceutical Solutions Not Applicable
23 Anti-Ulcer Agents Not Applicable
24 Antacids Not Applicable
25
Bismuth Not Applicable 7440-69-9 16682734 105143
26 Antibodies Not Applicable
27 Immunoglobulins Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
2 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3 Mesalamine
3 Budesonide for Induction of Remission in Incomplete Microscopic Colitis Recruiting NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
4 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
5 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
6 Rifaximin-treatment of Collagenous Colitis Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
7 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3 Budesonide;Placebo
8 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Completed NCT01209208 Phase 3 Budesonide;Mesalamine
9 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
10 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
11 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
12 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
13 Risk Factors for Microscopic Colitis Recruiting NCT02699333
14 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
15 Identification/Characterization of Changes in Microscopic Colitis Recruiting NCT03063957
16 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Enrolling by invitation NCT03275467 Not Applicable
17 Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis Completed NCT02303132 Not Applicable
18 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber
19 FMT in Inflammatory Bowel Disease Not yet recruiting NCT03477032
20 Interest of Pan-capsule in Symptomatic Patients Suspected of Irritable Bowel Syndrome Requiring Colonoscopy Recruiting NCT03806959 Not Applicable
21 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Recruiting NCT02284802 Not Applicable
22 Fecal Microbiota Transplantation for C Diff Infection Recruiting NCT01905709 Not Applicable

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

Genetic Tests for Microscopic Colitis

Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

42
Colon, T Cells, Bone, Thyroid, Small Intestine

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 379)
# Title Authors Year
1
Relative risk of microscopic colitis in dermatomyositis. ( 30910660 )
2019
2
Microscopic colitis: pathophysiology and clinical management. ( 30860066 )
2019
3
Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis. ( 30869794 )
2019
4
Management of microscopic colitis: challenges and solutions. ( 30881078 )
2019
5
Vedolizumab-Induced Remission in 3 Patients With Refractory Microscopic Colitis: A Tertiary Care Center Case Series. ( 30889247 )
2019
6
Cancer risk in microscopic colitis: a retrospective cohort study. ( 30611218 )
2019
7
Microscopic colitis: a narrative review with clinical approach. ( 30486642 )
2019
8
Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. ( 30181535 )
2019
9
Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease. ( 29603881 )
2018
10
Microscopic colitis-microbiome, barrier function and associated diseases. ( 29610731 )
2018
11
Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. ( 29852792 )
2018
12
Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. ( 29370359 )
2018
13
The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. ( 29610757 )
2018
14
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. ( 29742325 )
2018
15
Pembrolizumab-Induced Microscopic Colitis. ( 29610496 )
2018
16
Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )
2018
17
High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. ( 29977339 )
2018
18
Risk of osteoporosis in microscopic colitis. ( 29460653 )
2018
19
Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. ( 29204743 )
2018
20
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. ( 29535059 )
2018
21
Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. ( 29546806 )
2018
22
Microscopic Colitis: A Rare Cause of Pseudomembranes. ( 29981436 )
2018
23
Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis. ( 29457048 )
2018
24
Validating microscopic colitis (MC) in Swedish pathology registers. ( 30600733 )
2018
25
Obesity and Weight Gain Since Early Adulthood are Associated With a Lower Risk of Microscopic Colitis. ( 30529732 )
2018
26
Do Sex Hormones Cause, or Are They Only Associated With, Microscopic Colitis? ( 30419213 )
2018
27
Editorial: proton pump inhibitors (PPIs) and microscopic colitis. ( 30281829 )
2018
28
Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated. ( 30318685 )
2018
29
Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated-author's reply. ( 30318693 )
2018
30
Microscopic colitis: Diarrhoea or constipation. ( 30323375 )
2018
31
Proinflammatory Sulfur-Reducing Bacteria Are More Abundant in Colonic Biopsies of Patients with Microscopic Colitis Compared to Healthy Controls. ( 30324555 )
2018
32
Vedolizumab in refractory microscopic colitis: an international case series. ( 30329034 )
2018
33
Antidepressants and its relationship with microscopic colitis. ( 30338777 )
2018
34
Fatigue and its associated factors in microscopic colitis. ( 30228831 )
2018
35
Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. ( 30144433 )
2018
36
Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity? ( 30169584 )
2018
37
Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. ( 30039564 )
2018
38
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )
2017
39
Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )
2017
40
Letter: the definition of budesonide dependence in microscopic colitis-authors' reply. ( 28805323 )
2017
41
Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318707 )
2017
42
Endoscopic features of microscopic colitis: The "grid-like" pattern detected with HD+ colonoscopy plus i-scan. ( 28174001 )
2017
43
Continuing Medical Education: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050030 )
2017
44
Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )
2017
45
Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis? ( 28776143 )
2017
46
Macroscopic findings, incidence and characteristics of microscopic colitis in a large cohort of patients from the United Kingdom. ( 28562114 )
2017
47
Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis? ( 29078077 )
2017
48
Continuing Medical Education Questions: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050038 )
2017
49
Extended-release Multimatrix Budesonide for Microscopic Colitis. ( 28328627 )
2017
50
Early Life Exposure, Lifestyle, and Comorbidity as Risk Factors for Microscopic Colitis: A Case-Control Study. ( 28471835 )
2017

Variations for Microscopic Colitis

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CD79A HLA-DQB1 HLA-DRB1 IL2 PTEN TNF
2
Show member pathways
12.67 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
3
Show member pathways
12.58 IL2 IL6 PTEN TNF
4
Show member pathways
12.36 CD79A HLA-DQB1 HLA-DRB1 IL2 TNF
5
Show member pathways
12.34 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
6
Show member pathways
12.3 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
7
Show member pathways
12.19 HLA-DQB1 HLA-DRB1 IL2 PTEN
8
Show member pathways
12.08 HLA-DQB1 HLA-DRB1 TNF
9
Show member pathways
12.03 IL2 IL6 TNF
10 12 IL6 SLC6A4 TNF
11 11.99 HLA-DQB1 HLA-DRB1 IL6 TNF
12
Show member pathways
11.87 IL2 IL6 TNF
13 11.83 IL2 IL6 TNF
14
Show member pathways
11.78 IL6 PTEN TNF
15 11.69 CD79A IL2 IL6 TNF
16 11.69 HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
17 11.6 IL2 IL6 TNF
18 11.57 IL2 IL6 TNF
19 11.54 HLA-DQB1 HLA-DRB1 IL6 TNF
20
Show member pathways
11.5 IL2 IL6 TNF
21 11.42 HLA-DQB1 HLA-DRB1 IL6 TNF
22 11.36 IL2 IL6 TNF
23 11.08 HLA-DRB1 IL2
24 11.03 IL2 IL6 TNF
25 10.95 IL6 TNF
26 10.87 IL6 TNF
27 10.39 HLA-DRB1 IL2 IL6 TNF

GO Terms for Microscopic Colitis

Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.28 ATP12A ATP4A CD79A HLA-DQB1 HLA-DRB1 MR1
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DQB1 HLA-DRB1
3 MHC class II protein complex GO:0042613 8.96 HLA-DQB1 HLA-DRB1

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.84 IL6 PTEN SLC6A4 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.63 IL6 PTEN TNF
3 negative regulation of neurogenesis GO:0050768 9.58 IL6 TNF
4 brain morphogenesis GO:0048854 9.58 PTEN SLC6A4
5 positive regulation of chemokine production GO:0032722 9.57 IL6 TNF
6 cellular sodium ion homeostasis GO:0006883 9.56 ATP12A ATP4A
7 positive regulation of glial cell proliferation GO:0060252 9.55 IL6 TNF
8 response to organic substance GO:0010033 9.54 PTEN SLC6A4 TNF
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.52 ATP12A ATP4A
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.51 HLA-DQB1 HLA-DRB1
11 cellular potassium ion homeostasis GO:0030007 9.49 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.48 ATP12A ATP4A
13 positive regulation of immunoglobulin secretion GO:0051024 9.43 IL2 IL6
14 negative regulation of organ growth GO:0046621 9.4 PTEN SLC6A4
15 negative regulation of lipid storage GO:0010888 9.32 IL6 TNF
16 positive regulation of neuroinflammatory response GO:0150078 9.26 IL6 TNF
17 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DQB1 HLA-DRB1
18 immune response GO:0006955 9.1 HLA-DQB1 HLA-DRB1 IL2 IL6 MR1 TNF
19 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Microscopic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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