MCID: MCR191
MIFTS: 47

Microscopic Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Microscopic Colitis

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 15
Colitis, Microscopic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060182
ICD10 33 K52.83
MeSH 44 D046728
NCIt 50 C38504
UMLS 73 C0400821

Summaries for Microscopic Colitis

Disease Ontology : 12 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to lymphocytic colitis and inflammatory bowel disease. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are IL-2 Pathway and Allograft rejection. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 32.4 ATP12A ATP4A
2 inflammatory bowel disease 29.8 HLA-DQB1 HLA-DRB1 IL2 TNF
3 celiac disease 1 29.2 ATP12A ATP4A CD79A HLA-DQB1 IL2 TNF
4 collagenous colitis 12.1
5 colitis 10.9
6 diarrhea 10.4
7 microscopic polyangiitis 10.3 HLA-DRB1 TNF
8 anca-associated vasculitis 10.3 HLA-DRB1 TNF
9 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
10 actinic prurigo 10.3 HLA-DRB1 TNF
11 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
12 sympathetic ophthalmia 10.2 HLA-DRB1 TNF
13 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
14 nontuberculous mycobacterial lung disease 10.2 HLA-DRB1 TNF
15 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
16 metal allergy 10.2 HLA-DQB1 HLA-DRB1
17 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
18 central nervous system vasculitis 10.2 HLA-DRB1 TNF
19 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
20 rheumatoid vasculitis 10.2 HLA-DRB1 TNF
21 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
22 irritable bowel syndrome 10.2
23 chronic pulmonary heart disease 10.2 SLC6A4 TNF
24 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
25 whipple disease 10.2 HLA-DQB1 HLA-DRB1
26 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
27 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
28 idiopathic achalasia 10.2 HLA-DQB1 TNF
29 cardiac sarcoidosis 10.2 HLA-DQB1 TNF
30 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1
31 cow milk allergy 10.2 CD79A TNF
32 chronic graft versus host disease 10.2 CD79A TNF
33 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
34 osteosclerotic myeloma 10.2 CD79A TNF
35 peanut allergy 10.2 HLA-DQB1 HLA-DRB1
36 hemorrhagic fever 10.2 HLA-DRB1 TNF
37 sialadenitis 10.2 HLA-DQB1 TNF
38 alveolar echinococcosis 10.2 HLA-DRB1 TNF
39 uveoparotid fever 10.2 LYZ TNF
40 cytomegalovirus retinitis 10.2 HLA-DQB1 TNF
41 hypersensitivity vasculitis 10.2 CD79A HLA-DRB1
42 congenital toxoplasmosis 10.2 CD79A HLA-DQB1
43 periodic fever, familial, autosomal dominant 10.2 LYZ TNF
44 orofacial granulomatosis 10.2 CD79A TNF
45 acute disseminated encephalomyelitis 10.2 HLA-DQB1 HLA-DRB1
46 oral tuberculosis 10.2 IL2 TNF
47 immunoglobulin alpha deficiency 10.1 CD79A HLA-DQB1
48 hypersensitivity reaction type iii disease 10.1 CD79A TNF
49 berylliosis 10.1 HLA-DRB1 IL2
50 beryllium disease 10.1 HLA-DQB1 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis

Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 CD79A HLA-DQB1 SLC6A4
2 Decreased viability GR00381-A-3 9.28 CD79A HLA-DQB1 SLC6A4
3 Decreased viability GR00402-S-2 9.28 CD79A HLA-DQB1 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.87 ATP12A ATP4A HLA-DQB1 IL2 LYZ PTEN
2 homeostasis/metabolism MP:0005376 9.81 ATP12A ATP4A CD79A HLA-DQB1 IL2 LYZ
3 endocrine/exocrine gland MP:0005379 9.8 ATP4A HLA-DQB1 IL2 LYZ PTEN SLC6A4
4 liver/biliary system MP:0005370 9.43 CD79A HLA-DQB1 IL2 LYZ PTEN TNF
5 neoplasm MP:0002006 9.1 ATP4A CD79A IL2 LYZ PTEN TNF

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Not Applicable 51333-22-3 63006 5281004
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173
3 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
4 Analgesics Phase 2, Phase 3
5 Antirheumatic Agents Phase 2, Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
7 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Not Applicable
8 Mesalamine Phase 2, Phase 3 89-57-6
9 Analgesics, Non-Narcotic Phase 2, Phase 3
10 Hormone Antagonists Phase 3,Not Applicable
11 Hormones Phase 3,Not Applicable
12 Bronchodilator Agents Phase 3,Not Applicable
13 Autonomic Agents Phase 3,Not Applicable
14 Respiratory System Agents Phase 3,Not Applicable
15 Anti-Asthmatic Agents Phase 3,Not Applicable
16 glucocorticoids Phase 3,Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
18 Rifamycins Phase 3
19 Anti-Bacterial Agents Phase 3
20 Nucleic Acid Synthesis Inhibitors Phase 3
21 rifamycin SV Phase 3
22 Anti-Infective Agents Phase 3
23 Gastrointestinal Agents Phase 3,Not Applicable
24 Pharmaceutical Solutions Not Applicable
25 Cola Not Applicable
26 Anti-Ulcer Agents Not Applicable
27 Antacids Not Applicable
28
Bismuth Not Applicable 7440-69-9 16682734 105143

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3 Mesalamine
2 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
3 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
4 Budesonide for Induction of Remission in Incomplete Microscopic Colitis Recruiting NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
5 Rifaximin-treatment of Collagenous Colitis Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
6 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
7 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
8 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
9 Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis Completed NCT02303132 Not Applicable
10 Risk Factors for Microscopic Colitis Recruiting NCT02699333
11 Identification/Characterization of Changes in Microscopic Colitis Recruiting NCT03063957
12 Interest of Pan-capsule in Symptomatic Patients Suspected of Irritable Bowel Syndrome Requiring Colonoscopy Recruiting NCT03806959 Not Applicable
13 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Recruiting NCT02284802 Not Applicable
14 Fecal Microbiota Transplantation for C Diff Infection Recruiting NCT01905709 Not Applicable
15 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Enrolling by invitation NCT03275467 Not Applicable
16 FMT in Inflammatory Bowel Disease Not yet recruiting NCT03477032
17 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

Genetic Tests for Microscopic Colitis

Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

41
Colon, Bone, Lung, Heart, Lymph Node, Eye, Spinal Cord

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 373)
# Title Authors Year
1
Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease. ( 29603881 )
2018
2
Microscopic colitis-microbiome, barrier function and associated diseases. ( 29610731 )
2018
3
Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. ( 29852792 )
2018
4
Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. ( 29370359 )
2018
5
The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. ( 29610757 )
2018
6
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. ( 29742325 )
2018
7
Pembrolizumab-Induced Microscopic Colitis. ( 29610496 )
2018
8
Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )
2018
9
High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. ( 29977339 )
2018
10
Risk of osteoporosis in microscopic colitis. ( 29460653 )
2018
11
Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. ( 29204743 )
2018
12
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. ( 29535059 )
2018
13
Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. ( 29546806 )
2018
14
Microscopic Colitis: A Rare Cause of Pseudomembranes. ( 29981436 )
2018
15
Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis. ( 29457048 )
2018
16
Obesity and Weight Gain Since Early Adulthood are Associated With a Lower Risk of Microscopic Colitis. ( 30529732 )
2018
17
Do Sex Hormones Cause, or Are They Only Associated With, Microscopic Colitis? ( 30419213 )
2018
18
Microscopic colitis: a narrative review with clinical approach. ( 30486642 )
2018
19
Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated-author's reply. ( 30318693 )
2018
20
Microscopic colitis: Diarrhoea or constipation. ( 30323375 )
2018
21
Proinflammatory Sulfur-Reducing Bacteria Are More Abundant in Colonic Biopsies of Patients with Microscopic Colitis Compared to Healthy Controls. ( 30324555 )
2018
22
Vedolizumab in refractory microscopic colitis: an international case series. ( 30329034 )
2018
23
Antidepressants and its relationship with microscopic colitis. ( 30338777 )
2018
24
Editorial: proton pump inhibitors (PPIs) and microscopic colitis. ( 30281829 )
2018
25
Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated. ( 30318685 )
2018
26
Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. ( 30144433 )
2018
27
Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity? ( 30169584 )
2018
28
Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. ( 30181535 )
2018
29
Fatigue and its associated factors in microscopic colitis. ( 30228831 )
2018
30
Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. ( 30039564 )
2018
31
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )
2017
32
Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )
2017
33
Letter: the definition of budesonide dependence in microscopic colitis-authors' reply. ( 28805323 )
2017
34
Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318707 )
2017
35
Endoscopic features of microscopic colitis: The "grid-like" pattern detected with HD+ colonoscopy plus i-scan. ( 28174001 )
2017
36
Continuing Medical Education: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050030 )
2017
37
Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )
2017
38
Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis? ( 28776143 )
2017
39
Macroscopic findings, incidence and characteristics of microscopic colitis in a large cohort of patients from the United Kingdom. ( 28562114 )
2017
40
Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis? ( 29078077 )
2017
41
Continuing Medical Education Questions: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050038 )
2017
42
Extended-release Multimatrix Budesonide for Microscopic Colitis. ( 28328627 )
2017
43
Early Life Exposure, Lifestyle, and Comorbidity as Risk Factors for Microscopic Colitis: A Case-Control Study. ( 28471835 )
2017
44
Symptomatic Microscopic Colitis Atop Quiescent Inflammatory Bowel Disease: A Case Series. ( 29299484 )
2017
45
Antidepressant-Associated Microscopic Colitis: A Case Report and Literature Review. ( 28347506 )
2017
46
Case report: Pentoxifylline treatment in microscopic colitis. ( 29145246 )
2017
47
Diagnosis and Management of Microscopic Colitis. ( 27897155 )
2017
48
Microscopic Colitis After Fecal Microbiota Transplant. ( 28761890 )
2017
49
Letter: the definition of budesonide dependence in microscopic colitis. ( 28805319 )
2017
50
Over 90% of cases of Microscopic Colitis can be diagnosed by performing a short colonoscopy. ( 28215538 )
2017

Variations for Microscopic Colitis

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 CD79A HLA-DQB1 HLA-DRB1 IL2 PTEN TNF
2
Show member pathways
12.6 HLA-DQB1 HLA-DRB1 IL2 TNF
3
Show member pathways
12.47 HLA-DQB1 HLA-DRB1 IL2 TNF
4
Show member pathways
12.27 HLA-DQB1 HLA-DRB1 IL2 TNF
5 12.03 HLA-DQB1 HLA-DRB1 IL2 TNF
6 12.02 HLA-DQB1 HLA-DRB1 TNF
7
Show member pathways
11.96 HLA-DQB1 HLA-DRB1 TNF
8
Show member pathways
11.94 HLA-DQB1 HLA-DRB1 IL2 PTEN
9 11.92 HLA-DQB1 HLA-DRB1 TNF
10
Show member pathways
11.91 CD79A HLA-DQB1 HLA-DRB1 IL2 TNF
11 11.7 CD79A IL2 TNF
12 11.57 HLA-DQB1 HLA-DRB1 TNF
13 11.5 HLA-DQB1 HLA-DRB1 TNF
14 11.04 IL2 PTEN
15 10.97 HLA-DRB1 IL2
16 10.26 HLA-DRB1 IL2 TNF

GO Terms for Microscopic Colitis

Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.28 ATP12A ATP4A CD79A HLA-DQB1 HLA-DRB1 MAGI1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DQB1 HLA-DRB1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DQB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 8.96 HLA-DQB1 HLA-DRB1

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 HLA-DQB1 HLA-DRB1 IL2 TNF
2 ATP hydrolysis coupled proton transport GO:0015991 9.51 ATP12A ATP4A
3 brain morphogenesis GO:0048854 9.48 PTEN SLC6A4
4 cellular sodium ion homeostasis GO:0006883 9.46 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP12A ATP4A
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.4 HLA-DQB1 HLA-DRB1
7 cellular potassium ion homeostasis GO:0030007 9.37 ATP12A ATP4A
8 response to organic substance GO:0010033 9.33 PTEN SLC6A4 TNF
9 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
10 negative regulation of organ growth GO:0046621 9.26 PTEN SLC6A4
11 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
12 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.26 HLA-DQB1 HLA-DRB1
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Microscopic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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