Microscopic Colitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MCR191 MIFTS: 48	Microscopic Colitis Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Microscopic Colitis

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis ¹² ¹⁵ ¹⁷

Colitis, Microscopic ⁴⁵ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060182

MeSH ⁴⁵ D046728

NCIt ⁵¹ C38504

ICD10 ³⁴ K52.83

EFO ¹⁷ EFO_1001295

UMLS ⁷⁴ C0400821

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Summaries for Microscopic Colitis

Disease Ontology : ¹² A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to lymphocytic colitis and colitis. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are IL-2 Pathway and Allograft rejection. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁷ Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

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Related Diseases for Microscopic Colitis

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)

#	Related Disease	Score	Top Affiliating Genes
1	lymphocytic colitis	32.3	ATP12A ATP4A
2	colitis	31.6	IL2 IL6 TNF
3	inflammatory bowel disease	30.4	IL2 IL6 TNF
4	ulcerative colitis	30.2	IL2 IL6 TNF
5	diabetes mellitus	28.9	HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
6	collagenous colitis	12.2
7	sympathetic ophthalmia	10.4	HLA-DRB1 TNF
8	nontuberculous mycobacterial lung disease	10.4	HLA-DRB1 TNF
9	rheumatoid vasculitis	10.4	HLA-DRB1 TNF
10	chronic pulmonary heart disease	10.4	SLC6A4 TNF
11	rheumatoid arthritis, systemic juvenile	10.4	HLA-DRB1 IL6
12	cystic echinococcosis	10.4	HLA-DRB1 IL6
13	microscopic polyangiitis	10.4	HLA-DRB1 TNF
14	ischemic heart disease	10.4	IL6 TNF
15	autoimmune disease of eyes, ear, nose and throat	10.4	IL6 TNF
16	endometrial disease	10.4	IL6 TNF
17	meconium aspiration syndrome	10.4	IL6 TNF
18	listeriosis	10.4	IL6 TNF
19	louse-borne relapsing fever	10.4	IL6 TNF
20	poems syndrome	10.4	IL6 TNF
21	periapical periodontitis	10.4	IL6 TNF
22	stachybotrys chartarum	10.4	IL6 TNF
23	transverse myelitis	10.4	IL6 TNF
24	diarrhea	10.4
25	oral tuberculosis	10.4	IL2 TNF
26	hypersensitivity vasculitis	10.4	CD79A HLA-DRB1
27	primary effusion lymphoma	10.3	IL6 PTEN
28	orofacial granulomatosis	10.3	CD79A TNF
29	scorpion envenomation	10.3	IL6 TNF
30	capillary leak syndrome	10.3	IL2 IL6
31	necrotizing fasciitis	10.3	IL2 IL6
32	peanut allergy	10.3	HLA-DQB1 HLA-DRB1
33	leukomalacia	10.3	IL6 TNF
34	osteonecrosis of the jaw	10.3	HLA-DQB1 HLA-DRB1
35	berylliosis	10.3	HLA-DRB1 IL2
36	angioimmunoblastic lymphadenopathy with dysproteinemia	10.3	IL6 TNF
37	idiopathic bronchiectasis	10.3	HLA-DQB1 HLA-DRB1
38	sialadenitis	10.3	HLA-DQB1 TNF
39	autoimmune myocarditis	10.3	IL6 TNF
40	vulvovaginal candidiasis	10.3	CD79A IL2
41	limbic encephalitis with lgi1 antibodies	10.3	HLA-DQB1 HLA-DRB1
42	critical limb ischemia	10.3	IL6 TNF
43	farmer's lung	10.3	IL2 TNF
44	juvenile ankylosing spondylitis	10.3	IL6 TNF
45	cardiogenic shock	10.3	IL6 TNF
46	narcolepsy 2	10.3	HLA-DQB1 HLA-DRB1
47	autoimmune polyglandular syndrome type 3	10.3	HLA-DQB1 HLA-DRB1
48	mesangial proliferative glomerulonephritis	10.3	CD79A IL6
49	null-cell leukemia	10.3	IL6 TNF
50	retinitis pigmentosa 55	10.3	IL6 TNF

Graphical network of the top 20 diseases related to Microscopic Colitis:

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Symptoms & Phenotypes for Microscopic Colitis

GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00381-A-1	9.28	CD79A HLA-DQB1 SLC6A4
2	Decreased viability	GR00381-A-3	9.28	CD79A HLA-DQB1 SLC6A4
3	Decreased viability	GR00402-S-2	9.28	CD79A HLA-DQB1 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.95	ATP12A ATP4A HLA-DQB1 IL2 IL6 PTEN
2	hematopoietic system	MP:0005397	9.92	ATP4A CD79A HLA-DQB1 IL2 IL6 MR1
3	endocrine/exocrine gland	MP:0005379	9.91	ATP4A HLA-DQB1 IL2 IL6 PTEN SLC6A4
4	homeostasis/metabolism	MP:0005376	9.91	ATP12A ATP4A CD79A HLA-DQB1 IL2 IL6
5	immune system	MP:0005387	9.76	ATP4A CD79A HLA-DQB1 IL2 IL6 MR1
6	liver/biliary system	MP:0005370	9.43	CD79A HLA-DQB1 IL2 IL6 PTEN TNF
7	neoplasm	MP:0002006	9.1	ATP4A CD79A IL2 IL6 PTEN TNF

Sources

Drugs & Therapeutics for Microscopic Colitis

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Budesonide

Approved

Phase 3,Phase 2,Not Applicable

51333-22-3

63006 5281004

Synonyms:

(11b,16a)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde

(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde

(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione

16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

51333-22-3

AC1L1DQE

AC1L1Y6Y

AC1L22VC

AC1MHWI7

AC-4697

B 7777

B7777_SIGMA

Bidien

Bio-0010

BPBio1_000523

BRD-A34299591-001-03-4

BRD-A82238138-001-01-7

BSPBio_000475

BSPBio_002160

Budecort Inhaler

Budenofalk

Budeson

Budesónida

budesonide

Budesonide

Budesonide (JAN/USAN/INN)

Budesonide [USAN:INN:BAN:JAN]

Budesonide Easyhaler

Budesonide MMX

Budesonide, (R)-isomer

Budesonide, (S)-isomer

Budesonido

Budesonido [INN-Spanish]

Budesonidum

Budesonidum [INN-Latin]

Budiair

Budicort

C25H34O6

CCRIS 5230

CHEBI:3207

CHEBI:656601

CHEMBL1370

CID2462

CID3033890

CID40000

CID5281004

CID63006

Cortivent

CPD000058337

D00246

DB01222

Desowen

Dexbudesonide

Dexbudesonide [INN]

DivK1c_000475

EINECS 257-139-7

EINECS 257-160-1

EINECS 257-161-7

Entocort

Entocort EC

Entocort EC (TN)

EU-0100174

Giona Easyhaler

HMS1569H17

HMS1921I22

HMS2094I13

HMS501H17

Horacort

IDI1_000475

Inflammide

KBio1_000475

KBio3_001660

KBioGR_001361

Lopac0_000174

LS-187734

LS-7235

MAP-0010

Micronyl

Miflonide

MLS000028507

MLS001077323

MLS002207112

MolPort-002-529-265

MolPort-003-666-332

MolPort-003-986-909

NCGC00015165-03

NCGC00021318-03

NCGC00021318-06

NCGC00089747-02

NCGC00089747-03

NCGC00089747-04

NCGC00178789-01

NINDS_000475

Noex

Preferid

Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Prestwick_840

Prestwick0_000518

Prestwick1_000518

Prestwick2_000518

Prestwick3_000518

Pulmaxan

Pulmaxan turbohaler

Pulmicort

Pulmicort (TN)

Pulmicort Flexhaler

Pulmicort Nebuamp

Pulmicort Respules

Pulmicort Topinasal

Pulmicort turbuhaler

Pulmicort Turbuhaler

Respules

Rhinocort

Rhinocort alpha

Rhinocort Aqua

Rhinocort Turbuhaler

Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide

Rhinosol

S 1320

S1286_Selleck

S-1320

SAM002699898

SMR000058337

SPBio_000586

SPBio_002396

SPECTRUM1500813

Spectrum2_000623

Spectrum3_000620

Spectrum4_000821

Spectrum5_001738

Spirocort

ST51039033

TL8003397

Tridesilon

UDB

UNII-168L5HT37P

UNII-2HI1006KPH

UNII-Q3OKS62Q6X

Unit dose budesonide

ZINC03938751

ZINC04097286

Rifaximin

Approved, Investigational

Phase 3

80621-81-4

6436173 46783403

Synonyms:

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate

4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV

80621-81-4

88747-56-2

AC-19112

alpha-0817185

Bio-0556

BRN 3584528

C43H51N3O11

CHEMBL1617

D02554

DB01220

Fatroximin

Flonorm

L 105

L 105 (Ansamacrolide antibiotic)

L 105SV

Lormyx

LS-178059

LS-64147

Lumenax

MLS000759430

Normix

Redactiv

RedActiv

Rifacol

Rifamixin

Rifamycin L 105

Rifamycin L 105SV

Rifaxidin

Rifaximin

Rifaximin (USAN/INN)

Rifaximin [USAN:INN]

Rifaximina

Rifaximina [Spanish]

Rifaximine

Rifaximine [French]

Rifaximinum

Rifaximinum [Latin]

Rifaximinun

Rifaxin

Ritacol

S1790_Selleck

SMR000466324

Spiraxin

UNII-L36O5T016N

Xifaxan

Xifaxan, Rifacol, Fatroximin, Rifaximin

Xifaxsan

Xifaxsan (TN)

Peripheral Nervous System Agents

Phase 3,Phase 2,Not Applicable

Anti-Inflammatory Agents

Phase 3,Phase 2,Not Applicable

Hormones

Phase 3,Phase 2,Not Applicable

Anti-Asthmatic Agents

Phase 3,Phase 2,Not Applicable

Autonomic Agents

Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 3,Phase 2,Not Applicable

Bronchodilator Agents

Phase 3,Phase 2,Not Applicable

Respiratory System Agents

Phase 3,Phase 2,Not Applicable

glucocorticoids

Phase 3,Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Phase 2,Not Applicable

Analgesics, Non-Narcotic

Phase 2, Phase 3,Phase 3

Antirheumatic Agents

Phase 2, Phase 3,Phase 3

Analgesics

Phase 2, Phase 3,Phase 3

Mesalamine

Phase 2, Phase 3,Phase 3

89-57-6

Anti-Inflammatory Agents, Non-Steroidal

Phase 2, Phase 3,Phase 3

Gastrointestinal Agents

Phase 3,Not Applicable

Anti-Infective Agents

Phase 3

Anti-Bacterial Agents

Phase 3

Cola

Not Applicable

Pharmaceutical Solutions

Not Applicable

Anti-Ulcer Agents

Not Applicable

Antacids

Not Applicable

Bismuth

Not Applicable

7440-69-9

16682734 105143

Synonyms:

17034_FLUKA

24267-48-9

25243-76-9

264008_ALDRICH

265462_ALDRICH

265470_ALDRICH

452386_ALDRICH

556130_ALDRICH

7440-69-9

83Bi

95372_ALDRICH

95372_FLUKA

95375_FLUKA

AC1NSDYX

AC1O4PN8

AR-1I0647

Bi(3+)

Bismut

bismuth

Bismuth standard for AAS

Bismuth standard for ICP

Bismuth(III) cation

Bismuth(III) nitrate solution

BISMUTH, 99.95%

BISMUTH, 99.999%

Bismuth, elemental

Bismuth-209

bismuto

Bisumth(3+) ion

C15471

CHEBI:33301

CID5359367

EINECS 231-177-4

HSDB 2078

LS-44708

LTBB002773

MolPort-003-925-759

Wismut

Antibodies

Not Applicable

Immunoglobulins

Not Applicable

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	Long-Term Treatment of Collagenous Colitis With Budesonide	Unknown status	NCT00139165	Phase 3	Budesonide
2	Trial of Mesalamine for the Treatment of Active Microscopic Colitis	Completed	NCT00952952	Phase 2, Phase 3	Mesalamine
3	Budesonide for Induction of Remission in Incomplete Microscopic Colitis	Recruiting	NCT02142634	Phase 3	Budesonide granules 9 mg;Placebo granules
4	Budesonide Treatment for Lymphocytic Colitis	Completed	NCT00180050	Phase 3	Budesonide
5	Budesonide for Maintenance Treatment of Collagenous Colitis	Completed	NCT00180076	Phase 3	Budesonide
6	Rifaximin-treatment of Collagenous Colitis	Not yet recruiting	NCT03658993	Phase 3	Rifaximin 550 MG
7	SOIBD Collagenous Colitis Maintenance Study	Completed	NCT01278082	Phase 3	Budesonide;Placebo
8	Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis	Completed	NCT01209208	Phase 3	Budesonide;Mesalamine
9	Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis	Completed	NCT00450086	Phase 3	Budesonide;Mesalazine;Placebo
10	Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis	Terminated	NCT00217022	Phase 2, Phase 3	Budesonide
11	Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis	Unknown status	NCT01504048	Not Applicable
12	Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS)	Unknown status	NCT01787253
13	Risk Factors for Microscopic Colitis	Recruiting	NCT02699333
14	Case-Control Study to Identify Risk Factors for Microscopic Colitis	Completed	NCT01928667
15	Identification/Characterization of Changes in Microscopic Colitis	Recruiting	NCT03063957
16	Faecal Microbiota Transplantation in Patients With Microscopic Colitis	Enrolling by invitation	NCT03275467	Not Applicable
17	Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis	Completed	NCT02303132	Not Applicable
18	Treatment of Microscopic Colitis	Terminated	NCT00184171	Not Applicable	Budesonide;Bismuth;Fiber
19	FMT in Inflammatory Bowel Disease	Not yet recruiting	NCT03477032
20	Interest of Pan-capsule in Symptomatic Patients Suspected of Irritable Bowel Syndrome Requiring Colonoscopy	Recruiting	NCT03806959	Not Applicable
21	Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy	Recruiting	NCT02284802	Not Applicable
22	Fecal Microbiota Transplantation for C Diff Infection	Recruiting	NCT01905709	Not Applicable

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

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Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

MalaCards organs/tissues related to Microscopic Colitis:

⁴²

Colon, T Cells, Bone, Thyroid, Small Intestine

Sources

Publications for Microscopic Colitis

Articles related to Microscopic Colitis:

(show top 50) (show all 379)

#	Title	Authors	Year
1	Relative risk of microscopic colitis in dermatomyositis. ( 30910660 )	Pearson DR...Werth VP	2019
2	Microscopic colitis: pathophysiology and clinical management. ( 30860066 )	Miehlke S...M?nch A	2019
3	Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis. ( 30869794 )	Jaruvongvanich V...Ungprasert P	2019
4	Management of microscopic colitis: challenges and solutions. ( 30881078 )	Shor J...Marshall C	2019
5	Vedolizumab-Induced Remission in 3 Patients With Refractory Microscopic Colitis: A Tertiary Care Center Case Series. ( 30889247 )	Jennings JJ...Charabaty A	2019
6	Cancer risk in microscopic colitis: a retrospective cohort study. ( 30611218 )	Levy A...Ananthakrishnan AN	2019
7	Microscopic colitis: a narrative review with clinical approach. ( 30486642 )	Mosso E...Pellicano R	2019
8	Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. ( 30181535 )	Liu PH...Khalili H	2019
9	Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease. ( 29603881 )	Sonnenberg A....Genta R.M.	2018
10	Microscopic colitis-microbiome, barrier function and associated diseases. ( 29610731 )	van Hemert S....Marlicz W.	2018
11	Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. ( 29852792 )	Davidson S....Munck L.K.	2018
12	Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. ( 29370359 )	Burke K.E....Khalili H.	2018
13	The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. ( 29610757 )	Engel P.J.H....Kristensson M.	2018
14	Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. ( 29742325 )	Moore M....Loughrey M.B.	2018
15	Pembrolizumab-Induced Microscopic Colitis. ( 29610496 )	Ahmed M....Francis G.	2018
16	Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )	Holz K....Margolis R.L.	2018
17	High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. ( 29977339 )	Kane J.S....Ford A.C.	2018
18	Risk of osteoporosis in microscopic colitis. ( 29460653 )	Wildt S....Hitz M.F.	2018
19	Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. ( 29204743 )	NorAcn E....SAPderman J.	2018
20	Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. ( 29535059 )	Sonnenberg A....Genta R.M.	2018
21	Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. ( 29546806 )	Wickbom A....Tysk C.	2018
22	Microscopic Colitis: A Rare Cause of Pseudomembranes. ( 29981436 )	Schenck R.J....Pezhouh M.K.	2018
23	Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis. ( 29457048 )	Torres J....Borralho P.	2018
24	Validating microscopic colitis (MC) in Swedish pathology registers. ( 30600733 )	Svensson M...Ludvigsson JF	2018
25	Obesity and Weight Gain Since Early Adulthood are Associated With a Lower Risk of Microscopic Colitis. ( 30529732 )	Liu PH...Khalili H	2018
26	Do Sex Hormones Cause, or Are They Only Associated With, Microscopic Colitis? ( 30419213 )	Pabla B...Ness RM	2018
27	Editorial: proton pump inhibitors (PPIs) and microscopic colitis. ( 30281829 )	Krol R...van Oijen MGH	2018
28	Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated. ( 30318685 )	Tao P...Wang S	2018
29	Letter: the association between the use of different proton pump inhibitors and microscopic colitis should be re-evaluated-author's reply. ( 30318693 )	Bonderup OK	2018
30	Microscopic colitis: Diarrhoea or constipation. ( 30323375 )	Iqbal U...Anwar H	2018
31	Proinflammatory Sulfur-Reducing Bacteria Are More Abundant in Colonic Biopsies of Patients with Microscopic Colitis Compared to Healthy Controls. ( 30324555 )	Millien V...Shah R	2018
32	Vedolizumab in refractory microscopic colitis: an international case series. ( 30329034 )	Rivi?re P...Van Assche G	2018
33	Antidepressants and its relationship with microscopic colitis. ( 30338777 )	Hern?ndez-Huerta D...Mesonero-Gismero F	2018
34	Fatigue and its associated factors in microscopic colitis. ( 30228831 )	Kane JS...Ford AC	2018
35	Identification of Menopausal and Reproductive Risk Factors for Microscopic Colitis-Results From the Nurses' Health Study. ( 30144433 )	Burke KE...Khalili H	2018
36	Can Immune Checkpoint Inhibitors Induce Microscopic Colitis or a Brand New Entity? ( 30169584 )	Choi K...Wang Y	2018
37	Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. ( 30039564 )	Bonderup OK...Hallas J	2018
38	Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )	Gentile N....Yen E.F.	2017
39	Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )	Boland K....Nguyen G.C.	2017
40	Letter: the definition of budesonide dependence in microscopic colitis-authors' reply. ( 28805323 )	Cotter T.G....Pardi D.S.	2017
41	Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318707 )	Carmona-SA!nchez R.	2017
42	Endoscopic features of microscopic colitis: The &quot;grid-like&quot; pattern detected with HD+ colonoscopy plus i-scan. ( 28174001 )	Grassia R....Buffoli F.	2017
43	Continuing Medical Education: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050030 )		2017
44	Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )	Marlicz W....Koulaouzidis A.	2017
45	Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis? ( 28776143 )	Carrasco A....FernA!ndez-BaA+ares F.	2017
46	Macroscopic findings, incidence and characteristics of microscopic colitis in a large cohort of patients from the United Kingdom. ( 28562114 )	Kane J.S....Ford A.C.	2017
47	Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis? ( 29078077 )	Rizzo A.G....Cottone M.	2017
48	Continuing Medical Education Questions: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050038 )	Carpenter S.L.	2017
49	Extended-release Multimatrix Budesonide for Microscopic Colitis. ( 28328627 )	Kamboj A.K....Pardi D.S.	2017
50	Early Life Exposure, Lifestyle, and Comorbidity as Risk Factors for Microscopic Colitis: A Case-Control Study. ( 28471835 )	Verhaegh B.P.M....Jonkers D.M.A.E.	2017

Sources

Genes for Microscopic Colitis

Genes related to Microscopic Colitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TNF	Tumor Necrosis Factor	Protein Coding	21.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	19.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	16.93	GeneCards inferred via : Publications (show sections)
4	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	16.84	DISEASES inferred ¹⁵
5	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	16.84	DISEASES inferred ¹⁵
6	PTEN	Phosphatase And Tensin Homolog	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
7	IL2	Interleukin 2	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
8	IL6	Interleukin 6	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
9	CD79A	CD79a Molecule	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
10	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)
11	MR1	Major Histocompatibility Complex, Class I-Related	Protein Coding	16.58	GeneCards inferred via : Publications (show sections)

Sources

Variations for Microscopic Colitis

Sources

Expression for Microscopic Colitis

Search GEO for disease gene expression data for Microscopic Colitis.

Sources

Pathways for Microscopic Colitis

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	IL-2 Pathway ⁶⁵ Show member pathways ErbB Family Pathway ⁶⁵ ErbB2-ErbB3 Heterodimers ⁶⁵ ErbB4 Pathway ⁶⁵ Growth Hormone Signaling ⁶⁵ HMGB1 Pathway ⁶⁵ IL-4 Pathway ⁶⁵ LPS Stimulated MAPK Signaling ⁶⁵ PACAP Signaling ⁶⁵ PI3K Signaling in B-Lymphocyte ⁶⁵ Prolactin Signaling ⁶⁵ Thrombopoietin Pathway ⁶⁵ TREM1 Pathway ⁶⁵ UVC-Induced MAPK Signaling ⁶⁵	12.96	CD79A HLA-DQB1 HLA-DRB1 IL2 PTEN TNF
2	Allograft rejection ¹ ³⁸ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.67	HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
3	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁶ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁶ Development Thrombopoietin-regulated cell processes ²³ IL-15 Signaling Pathways ⁶⁶ IL-2 Signaling Pathways ⁶⁶ IL-21 Signaling Pathways ⁶⁶ IL-4 Signaling Pathways ⁶⁶ IL-7 Signaling Pathways ⁶⁶ IL-9 Pathway ⁶⁵ IL-9 Signaling Pathways ⁶⁶ Immune response IL-9 signaling pathway ²³	12.58	IL2 IL6 PTEN TNF
4	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.36	CD79A HLA-DQB1 HLA-DRB1 IL2 TNF
5	Influenza A ³⁸ Show member pathways Measles ³⁸	12.34	HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
6	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.3	HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
7	ICos-ICosL Pathway in T-Helper Cell ⁶⁵ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁵ CD28 Signaling in T-Helper Cell ⁶⁵	12.19	HLA-DQB1 HLA-DRB1 IL2 PTEN
8	Toxoplasmosis ³⁸ Show member pathways Leishmaniasis ³⁸	12.08	HLA-DQB1 HLA-DRB1 TNF
9	C-type lectin receptor signaling pathway ³⁸ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁶	12.03	IL2 IL6 TNF
10	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12	IL6 SLC6A4 TNF
11	Tuberculosis ³⁸	11.99	HLA-DQB1 HLA-DRB1 IL6 TNF
12	Th1 Differentiation Pathway ⁶⁶ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁶	11.87	IL2 IL6 TNF
13	Spinal Cord Injury ¹	11.83	IL2 IL6 TNF
14	Insulin resistance ³⁸ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.78	IL6 PTEN TNF
15	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.69	CD79A IL2 IL6 TNF
16	Human T-cell leukemia virus 1 infection ³⁸	11.69	HLA-DQB1 HLA-DRB1 IL2 IL6 TNF
17	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11.6	IL2 IL6 TNF
18	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁶	11.57	IL2 IL6 TNF
19	Hematopoietic cell lineage ³⁸	11.54	HLA-DQB1 HLA-DRB1 IL6 TNF
20	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.5	IL2 IL6 TNF
21	Rheumatoid arthritis ³⁸	11.42	HLA-DQB1 HLA-DRB1 IL6 TNF
22	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.36	IL2 IL6 TNF
23	IL12 signaling mediated by STAT4 ¹	11.08	HLA-DRB1 IL2
24	G-protein signaling_RhoB regulation pathway ²³	11.03	IL2 IL6 TNF
25	Transcription factor regulation in adipogenesis ¹	10.95	IL6 TNF
26	Overview of nanoparticle effects ¹	10.87	IL6 TNF
27	Cytokines and Inflammatory Response ¹	10.39	HLA-DRB1 IL2 IL6 TNF

Sources

GO Terms for Microscopic Colitis

Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.28	ATP12A ATP4A CD79A HLA-DQB1 HLA-DRB1 MR1
2	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	9.16	HLA-DQB1 HLA-DRB1
3	MHC class II protein complex	GO:0042613	8.96	HLA-DQB1 HLA-DRB1

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 19)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.84	IL6 PTEN SLC6A4 TNF
2	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.63	IL6 PTEN TNF
3	negative regulation of neurogenesis	GO:0050768	9.58	IL6 TNF
4	brain morphogenesis	GO:0048854	9.58	PTEN SLC6A4
5	positive regulation of chemokine production	GO:0032722	9.57	IL6 TNF
6	cellular sodium ion homeostasis	GO:0006883	9.56	ATP12A ATP4A
7	positive regulation of glial cell proliferation	GO:0060252	9.55	IL6 TNF
8	response to organic substance	GO:0010033	9.54	PTEN SLC6A4 TNF
9	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.52	ATP12A ATP4A
10	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	9.51	HLA-DQB1 HLA-DRB1
11	cellular potassium ion homeostasis	GO:0030007	9.49	ATP12A ATP4A
12	sodium ion export across plasma membrane	GO:0036376	9.48	ATP12A ATP4A
13	positive regulation of immunoglobulin secretion	GO:0051024	9.43	IL2 IL6
14	negative regulation of organ growth	GO:0046621	9.4	PTEN SLC6A4
15	negative regulation of lipid storage	GO:0010888	9.32	IL6 TNF
16	positive regulation of neuroinflammatory response	GO:0150078	9.26	IL6 TNF
17	humoral immune response mediated by circulating immunoglobulin	GO:0002455	9.16	HLA-DQB1 HLA-DRB1
18	immune response	GO:0006955	9.1	HLA-DQB1 HLA-DRB1 IL2 IL6 MR1 TNF
19	immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	8.96	HLA-DQB1 HLA-DRB1

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP12A ATP4A
2	MHC class II receptor activity	GO:0032395	8.96	HLA-DQB1 HLA-DRB1
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP12A ATP4A

Sources

Sources for Microscopic Colitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia