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MCID: MCR191
MIFTS: 46

Microscopic Colitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Microscopic Colitis

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MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 15 17
Colitis, Microscopic 43 71

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060182
MeSH 43 D046728
NCIt 49 C38504
SNOMED-CT 67 235753003
ICD10 32 K52.83
UMLS 71 C0400821
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Summaries for Microscopic Colitis

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Disease Ontology : 12 A colitis that can only be diagnosed by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to colitis and lymphocytic colitis. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. The drugs Colestipol and Hypolipidemic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and small intestine, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

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Related Diseases for Microscopic Colitis

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Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 511)
# Related Disease Score Top Affiliating Genes
1 colitis 31.5 TNF IL6 IL4 IL2 IFNG HLA-DRB1
2 lymphocytic colitis 31.3 TOR1A TNF TGM2 ATP4A ATP12A
3 diarrhea 30.9 TNF TGM2 SLC6A4 IL6 IL2 IFNG
4 irritable bowel syndrome 30.8 TNF TGM2 SLC6A4 IL6
5 ulcerative colitis 30.5 TNF IL6 IL4 IL2 IFNG HLA-DRB1
6 crohn's colitis 30.4 TNF IL2 IFNG
7 crohn's disease 30.4 TNF IL6 IL4 IL2 IFNG HLA-DRB1
8 gastroenteritis 30.3 TNF IL6 IL4 IFNG
9 esophagitis 30.2 TNF IL6 IL4
10 thyroiditis 30.2 TNF IL6 IL4 IL2
11 inflammatory bowel disease 30.1 TNF IL6 IL4 IL2 IL15 IFNG
12 refractory celiac disease 30.1 IL15 IFNG HLA-DQB1
13 spondylitis 30.1 TNF IL6 IFNG
14 bacterial infectious disease 30.0 TNF IL6 IL15 IFNG
15 bullous pemphigoid 29.9 TNF IL4 HLA-DRB1 HLA-DQB1
16 cholera 29.8 TNF IL6 IL4 CD79A
17 uveitis 29.7 TNF IL6 IL4 IL2 IFNG
18 lung disease 29.6 TNF IL6 IL4 IL15 IFNG
19 graft-versus-host disease 29.5 TNF IL6 IL2 IFNG HLA-DRB1 HLA-DQB1
20 eosinophilic gastroenteritis 29.3 IL4 ATP4A ATP12A
21 dermatitis herpetiformis 29.2 TNF TGM2 IL4 HLA-DQB1 CD79A
22 constipation 29.2 TNF TGM2 SLC6A4 IL6 ATP4A ATP12A
23 bone resorption disease 29.2 TNF IL6 ATP4A ATP12A
24 eye disease 29.1 TNF MIR126 IL6 IL4 IL2 IFNG
25 autoimmune disease 29.1 TNF TGM2 IL6 IL4 IL2 IL15
26 osteoporosis 28.9 TNF TGM2 IL6 IL4 IL2 IFNG
27 diabetes mellitus 28.7 TNF MIR126 IL6 IL4 IL2 IFNG
28 lymphocytic gastritis 28.4 TOR1A TGM2 ATP4A ATP12A
29 tropical sprue 28.4 TOR1A TGM2 ATP4A ATP12A
30 celiac disease 1 27.0 TOR1A TNF TGM2 IL6 IL4 IL2
31 collagenous colitis 12.3
32 external pathological resorption 10.6 TNF IL6
33 scorpion envenomation 10.6 TNF IL6
34 microscopic polyangiitis 10.6 TNF HLA-DRB1
35 tropical endomyocardial fibrosis 10.6 TNF IL4
36 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.6 IL4 IL2
37 idiopathic anterior uveitis 10.6 TNF IL6
38 limbic encephalitis with lgi1 antibodies 10.5 HLA-DRB1 HLA-DQB1
39 staphylococcal toxic shock syndrome 10.5 TNF IFNG
40 autoimmune myocarditis 10.5 TNF IFNG
41 autoimmune polyglandular syndrome type 3 10.5 HLA-DRB1 HLA-DQB1
42 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
43 spotted fever rickettsiosis 10.5 TNF IFNG
44 hypersomnia 10.5 HLA-DRB1 HLA-DQB1
45 virus associated hemophagocytic syndrome 10.5 IL4 IL2
46 narcolepsy 2 10.5 HLA-DRB1 HLA-DQB1
47 primary adrenal insufficiency 10.5 HLA-DRB1 HLA-DQB1
48 type ii mixed cryoglobulinemia 10.5 HLA-DRB1 HLA-DQB1
49 moyamoya angiopathy 10.5 HLA-DRB1 HLA-DQB1
50 fixed drug eruption 10.5 IL2 IFNG

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis
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Symptoms & Phenotypes for Microscopic Colitis

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MGI Mouse Phenotypes related to Microscopic Colitis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ATP12A ATP4A CD79A HLA-DQB1 IFNG IL2
2 hematopoietic system MP:0005397 10.21 ATP4A CD79A HLA-DQB1 IFNG IL15 IL2
3 endocrine/exocrine gland MP:0005379 10.2 ATP4A HLA-DQB1 IFNG IL15 IL2 IL4
4 cardiovascular system MP:0005385 10.19 HLA-DQB1 IFNG IL15 IL2 IL6 LYZ
5 digestive/alimentary MP:0005381 10.18 ATP12A ATP4A HLA-DQB1 IFNG IL2 IL4
6 immune system MP:0005387 10.15 ATP4A CD79A HLA-DQB1 IFNG IL15 IL2
7 liver/biliary system MP:0005370 9.92 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
8 neoplasm MP:0002006 9.86 ATP4A CD79A IFNG IL2 IL6 LYZ
9 no phenotypic analysis MP:0003012 9.7 CD79A IFNG IL2 IL4 LYZ TGM2
10 renal/urinary system MP:0005367 9.65 ATP12A CD79A HLA-DQB1 IFNG IL15 IL4
11 respiratory system MP:0005388 9.23 HLA-DQB1 IFNG IL2 IL4 IL6 LYZ
Sources

Drugs & Therapeutics for Microscopic Colitis

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Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colestipol Approved Phase 4 26658-42-4
2 Hypolipidemic Agents Phase 4
3 Lipid Regulating Agents Phase 4
4 Colesevelam Hydrochloride Phase 4
5 Anticholesteremic Agents Phase 4
6 Cholestyramine Resin Phase 4
7 Antimetabolites Phase 4
8 Bile Acids and Salts Phase 4
9
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173 46783403
10
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
11 Mesalamine Phase 2, Phase 3 89-57-6
12 Analgesics, Non-Narcotic Phase 2, Phase 3
13 Analgesics Phase 2, Phase 3
14 Antirheumatic Agents Phase 2, Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
16 Gastrointestinal Agents Phase 3
17 Anti-Bacterial Agents Phase 3
18 Anti-Infective Agents Phase 3
19 Respiratory System Agents Phase 2, Phase 3
20 Hormones Phase 2, Phase 3
21 Anti-Asthmatic Agents Phase 2, Phase 3
22 Hormone Antagonists Phase 2, Phase 3
23 glucocorticoids Phase 2, Phase 3
24 Bronchodilator Agents Phase 2, Phase 3
25 Anti-Inflammatory Agents Phase 2, Phase 3
26 Pharmaceutical Solutions
27 Cola
28 Immunoglobulins
29 Antibodies
30 Antacids
31 Anti-Ulcer Agents
32
Bismuth 7440-69-9 16682734 105143
33
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Treatment Effect of Colesevelam for Bile Acid Diarrhoea - a Randomised Placebo-controlled Trial Recruiting NCT03876717 Phase 4 Colesevelam Hydrochloride;Placebo oral capsule
2 Efficacy and Safety of Budesonide for Treatment of Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
3 Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
4 A Randomized, Dose Ranging Trial of Mesalmine for the Treatment of Active Microscopic Colitis. Completed NCT00952952 Phase 2, Phase 3 Mesalamine
5 Effect of Mesalazine on Low Grade Mucosal Inflammation in Irritable Bowel Syndrome. A Pilot Double Blind Placebo Controlled Study. Completed NCT00774007 Phase 2, Phase 3 mesalazine;placebo
6 Randomised, Double-blind, Placebo-controlled, Multi-centre Trial on the Efficacy and Safety of Budesonide for Induction of Remission in Incomplete Microscopic Colitis Active, not recruiting NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
7 Rifaximin-treatment of Collagenous Colitis: Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
8 A Randomized, Double-Blind, Placebo Controlled Trial of Budesonide for the Treatment of Active Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
9 Efficacy and Safety of Oral Rifaximin in Patients With Active Microscopic Colitis Recruiting NCT04043897 Phase 2 Rifaximin 550mg
10 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
11 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
12 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
13 Ex Vivo Experiments to Evaluate the Role of Medication on the Colon Permeability in Microscopic Colitis Completed NCT02303132
14 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Completed NCT03275467
15 Effects of Faecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome: A Randomised, Double-blind Placebo-controlled Study Completed NCT03822299
16 Faecal Transplantation in Inflammatory Bowel Disease Recruiting NCT03477032
17 Risk Factors for Microscopic Colitis Recruiting NCT02699333
18 Identification and Characterization of Microbial and Immunologic Changes in Microscopic Colitis Recruiting NCT03063957
19 Interest of Pan Capsule (Small Bowel and Colon Video Capsule) in Symptomatic Patients Suspected of Irritable Bowel Syndrome Requiring Colonoscopy. Phase A. Feasibility Recruiting NCT03806959
20 Fecal Microbiota Transplantation for the Treatment of Recurrent or Refractory Clostridium Difficile Infection (CDI) Recruiting NCT01905709
21 Investigating Serotonin Signalling in IBD Patients Recruiting NCT01650311
22 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Recruiting NCT02284802
23 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

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Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

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MalaCards organs/tissues related to Microscopic Colitis:

40
Colon, T Cells, Small Intestine, Testes, Bone, Liver, Thyroid
Sources

Publications for Microscopic Colitis

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Articles related to Microscopic Colitis:

(show top 50) (show all 790)
# Title Authors PMID Year
1
Vedolizumab for the Induction of Remission in Treatment-refractory Microscopic Colitis in a Pediatric Patient. 61
32304548 2020
2
Incidence and prevalence of microscopic colitis between 2001 and 2016: A Danish nationwide cohort study. 61
32502240 2020
3
Diabetic Diarrhea: Comments on Workup of SIBO and Microscopic Colitis. 61
32285319 2020
4
Gluten-free Diet in IBD: Time for a Recommendation? 61
32558265 2020
5
Anti-Inflammatory Effect of Crude Momordica charantia L. Extract on 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Model in Rat and the Bioaccessibility of its Carotenoid Content. 61
31702423 2020
6
[The general practitioner's knowledge and attitude towards proton pump inhibitors adverse effects]. 61
31471066 2020
7
Editorial: long-term oral budesonide treatment and risk of osteoporotic fractures in patients with microscopic colitis-not a totally clean bill of health. 61
32338783 2020
8
Safety of Immune Checkpoint Inhibitors in Patients With Pre-Existing Inflammatory Bowel Disease and Microscopic Colitis. 61
32401685 2020
9
Anti-PD-1 induced collagenous colitis in metastatic melanoma: a rare severe adverse event. 61
32404733 2020
10
Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study. 61
31926169 2020
11
Clozapine-Related Diarrhea and Colitis: Report of 4 Cases. 61
32332465 2020
12
Successful use of beclometasone dipropionate for the treatment of microscopic colitis. 61
32448057 2020
13
An investigation of European pathologists' approach to diagnose microscopic colitis. 61
32278285 2020
14
Microscopic Colitis Is Characterized by Intestinal Dysbiosis. 61
31254673 2020
15
Methodological approach to Microscopic Colitis diagnosis. 61
31942642 2020
16
Methodological approach to microscopic colitis diagnosis: reply. 61
31980960 2020
17
Pediatric facial pyoderma gangrenosum preceding the diagnosis of inflammatory bowel disease. 61
32342563 2020
18
Chronic Diarrhea in Adults: Evaluation and Differential Diagnosis. 61
32293842 2020
19
Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy. 61
32338534 2020
20
Visible or invisible atypical form of microscopic colitis with giant cells: for the endoscopist, that is the question. 61
32303078 2020
21
Topography, morphology, and etiology of lymphocytic gastritis: a single institution experience. 61
31897816 2020
22
Rational investigations in irritable bowel syndrome. 61
32133113 2020
23
Gastrointestinal and Hepatic Complications of Immunotherapy: Current Management and Future Perspectives. 61
32185493 2020
24
Microscopic colitis and its associations with complications observed in classic inflammatory bowel disease: a systematic review. 61
32182146 2020
25
Long-term oral budesonide treatment and risk of osteoporotic fractures in patients with microscopic colitis. 61
32003028 2020
26
The association between smoking and both types of microscopic colitis: A systematic review and meta-analysis. 61
32241698 2020
27
Biopsies From Ascending and Descending Colon Are Sufficient for Diagnosis of Microscopic Colitis. 61
32109628 2020
28
High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study. 61
32111632 2020
29
Comorbid Occurrence of Eosinophilic Esophagitis and Inflammatory Bowel Disease. 61
32068153 2020
30
Diagnostic Yield of Colonoscopy in Young Adults with Lower Gastrointestinal Symptoms in a Multicenter Midwest Cohort. 61
32088711 2020
31
[An unusual digestive complication under anti-PD-1 (pembrolizumab)]. 61
32107038 2020
32
The effect of fecal microbiota transplantation on IBS related quality of life and fatigue in moderate to severe non-constipated irritable bowel: Secondary endpoints of a double blind, randomized, placebo-controlled trial. 61
31877418 2020
33
Faecal Calprotectin and 7-α Cholestenone Levels in Microscopic Colitis: Experience from Edinburgh. 61
32440188 2020
34
Lower gastrointestinal symptoms and symptoms-based triaging systems are poor predictors of clinical significant disease on colonoscopy. 61
32337053 2020
35
De Novo Colitis Associated With Rituximab in 21 Patients at a Tertiary Center. 61
30905719 2020
36
Undiagnosed microscopic colitis: a hidden cause of chronic diarrhoea and a frequently missed treatment opportunity. 61
32419914 2020
37
Corrigendum: Biomarkers and Microscopic Colitis: An Unmet Need in Clinical Practice. 61
32083085 2020
38
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. 61
31880163 2020
39
[About a case of microscopic colitis under lansoprazole]. 61
32200991 2020
40
Clinical characteristics of colitis induced by taxane-based chemotherapy. 61
31892799 2020
41
Increased Mast Cell Counts and Degranulation in Microscopic Colitis. 61
32148478 2020
42
Microscopic Colitis: A Challenging Disorder. 61
31865352 2020
43
Mortality of Patients With Microscopic Colitis in Sweden. 61
31857243 2019
44
Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. 61
31125052 2019
45
Colonic Manifestations and Complications Are Relatively Under-Reported in Systemic Sclerosis: A Systematic Review. 61
31805016 2019
46
Usefulness of fecal calprotectin as a biomarker of microscopic colitis in a cohort of patients with chronic watery diarrhoea of functional characteristics. 61
31383457 2019
47
Budesonide treatment for microscopic colitis from immune checkpoint inhibitors. 61
31699151 2019
48
Relative risk of microscopic colitis in dermatomyositis. 61
30910660 2019
49
Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis. 61
30529732 2019
50
Single-centre experience with anti-tumour necrosis factor treatment in budesonide-refractory microscopic colitis patients. 61
31700636 2019
Sources

Variations for Microscopic Colitis

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Expression for Microscopic Colitis

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Search GEO for disease gene expression data for Microscopic Colitis.
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Pathways for Microscopic Colitis

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Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.35 TNF IL6 IL4 IL2 IL15 IFNG
2
IL-2 Pathway 63
Show member pathways
 13.21 TNF IL4 IL2 IFNG HLA-DRB1 HLA-DQB1
3
Measles 36
Show member pathways
 12.81 TNF IL6 IL2 IFNG HLA-DRB1 HLA-DQB1
4
Herpes simplex virus 1 infection 36
12.79 TNF IL6 IFNG HLA-DRB1 HLA-DQB1
5
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.77 TNF IL6 IL4 IL2 IL15
6
Allograft rejection 1 36
Show member pathways
 12.67 TNF IL6 IL4 IL2 IL15 IFNG
7
T cell receptor signaling pathway 36
Show member pathways
 12.59 TNF IL6 IL4 IL2 IFNG
8
Immune response NFAT in immune response 22
Show member pathways
 12.58 TNF IL4 IL2 IFNG HLA-DRB1 HLA-DQB1
9
NF-kappaB Signaling 4
12.56 TNF IL4 IL2 IFNG CD79A
10
Th17 cell differentiation 36
Show member pathways
 12.49 TNF IL6 IL4 IL2 IFNG HLA-DRB1
11
JAK-STAT signaling pathway 36
Show member pathways
 12.45 IL6 IL4 IL2 IL15 IFNG
12
Folate Metabolism 1
Show member pathways
 12.33 TNF IL6 IL4 IL2 IFNG
13
IL-17 Family Signaling Pathways 64
Show member pathways
 12.32 TNF IL6 IL4 IFNG
14
Human T-cell leukemia virus 1 infection 36
12.27 TNF IL6 IL2 IL15 HLA-DRB1 HLA-DQB1
15
Toxoplasmosis 36
Show member pathways
 12.24 TNF IL4 IFNG HLA-DRB1 HLA-DQB1
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.23 TNF IL6 IL4 IL2 IL15 IFNG
17
Tuberculosis 36
12.21 TNF IL6 IFNG HLA-DRB1 HLA-DQB1
18
Bacterial infections in CF airways 22
Show member pathways
 12.19 TNF IL6 IL4 IFNG
19
Jak Stat Signaling Pathway 66
Show member pathways
 12.1 IL4 IL2 IL15
20
Spinal Cord Injury 1
11.99 TNF IL6 IL4 IL2 IFNG
21
IL12-mediated signaling events 1
Show member pathways
 11.98 IL4 IL2 IFNG HLA-DRB1
22
IL27-mediated signaling events 1
Show member pathways
 11.94 TNF IL6 IL2 IFNG
23
Hematopoietic cell lineage 36
11.83 TNF IL6 IL4 HLA-DRB1 HLA-DQB1
24
Glucocorticoid receptor regulatory network 1
11.81 IL6 IL4 IL2 IFNG
25
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 TNF IL4 IL2 IFNG
26
Dendritic Cells Developmental Lineage Pathway 64
11.75 TNF IL6 IL2 IFNG
27
Rheumatoid arthritis 36
11.7 TNF IL6 IL15 IFNG HLA-DRB1 HLA-DQB1
28
Innate Lymphoid Cells Differentiation 64
11.67 TNF IL4 IL2 IL15 IFNG
29
Lung fibrosis 1
11.66 TNF IL6 IL4
30
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.64 TNF IL2 IFNG
31
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.64 TNF IL6 IL2 IFNG
32
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.56 TNF IL6 IL4 IL2 IL15 IFNG
33
Malaria 36
11.55 TNF IL6 IFNG
34
Interleukin-10 signaling 65
11.54 TNF IL6 IL4
35
Photodynamic therapy-induced AP-1 survival signaling. 1
11.53 TNF IL6 IL2 IFNG
36
Aryl Hydrocarbon Receptor Pathway 1
11.52 TNF IL2 IFNG
37
Th2 Differentiation 64
11.5 IL4 IL2 IFNG
38
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.49 TNF IL6 IFNG
39
African trypanosomiasis 36
11.39 TNF IL6 IFNG
40
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.35 TNF IL2 IL15 IFNG
41
Inflammatory Response Pathway 1
11.33 IL4 IL2 IFNG
42
IL12 signaling mediated by STAT4 1
11.24 IL2 IFNG HLA-DRB1
43
OX40 Pathway 63
11.2 IL4 IL2 IFNG
44
Development and heterogeneity of the ILC family 1
11.06 TNF IL6 IL4 IL15 IFNG
45
EV release from cardiac cells and their functional effects 1
10.64 TNF MIR126
46
Cytokines and Inflammatory Response 1
10.63 TNF IL6 IL4 IL2 IL15 IFNG
Sources

GO Terms for Microscopic Colitis

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Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 TNF MR1 MIR126 LYZ IL6 IL4

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.04 TNF SLC6A4 IL6 IL4 IFNG
2 positive regulation of protein phosphorylation GO:0001934 9.88 TNF IL2 IFNG HLA-DRB1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.79 IFNG HLA-DRB1 HLA-DQB1
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF TGM2 IL6
5 humoral immune response GO:0006959 9.77 TNF IL6 IFNG
6 defense response to Gram-positive bacterium GO:0050830 9.76 TNF MR1 LYZ IL6
7 positive regulation of phagocytosis GO:0050766 9.7 TNF IL15 IFNG
8 microglial cell activation GO:0001774 9.65 TNF IL4 IFNG
9 negative regulation of amyloid-beta clearance GO:1900222 9.64 TNF IFNG
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 IL4 IL2
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL4 IFNG
12 positive regulation of inflammatory response GO:0050729 9.63 TNF TGM2 MIR126 IL2 IL15 IFNG
13 negative regulation of lipid storage GO:0010888 9.62 TNF IL6
14 positive regulation of T cell proliferation GO:0042102 9.62 IL6 IL4 IL2 IL15
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.61 IL4 IL2
16 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.61 TNF IFNG
17 immune response GO:0006955 9.61 TNF MR1 IL6 IL4 IL2 IL15
18 positive regulation of mononuclear cell migration GO:0071677 9.58 TNF IL4
19 positive regulation of tissue remodeling GO:0034105 9.57 IL2 IL15
20 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.56 HLA-DRB1 HLA-DQB1
21 positive regulation of cellular respiration GO:1901857 9.55 IL4 IFNG
22 neuroinflammatory response GO:0150076 9.54 IL4 IFNG
23 macrophage differentiation GO:0030225 9.54 IL15 IFNG HLA-DRB1
24 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.51 HLA-DRB1 HLA-DQB1
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IFNG
26 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 TNF IFNG
27 positive regulation of chemokine biosynthetic process GO:0045080 9.43 TNF IL4 IFNG
28 positive regulation of nitrogen compound metabolic process GO:0051173 9.4 TNF IFNG
29 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.1 TNF IL6 IL4 IL2 IL15 IFNG

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
2 MHC class II receptor activity GO:0032395 9.26 HLA-DRB1 HLA-DQB1
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 cytokine activity GO:0005125 9.1 TNF IL6 IL4 IL2 IL15 IFNG
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
Sources

Sources for Microscopic Colitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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