Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: MCR191
MIFTS: 46

Microscopic Colitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Microscopic Colitis

About this section

MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 15 17
Colitis, Microscopic 44 71

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060182
MeSH 44 D046728
NCIt 50 C38504
SNOMED-CT 67 235753003
ICD10 32 K52.83
UMLS 71 C0400821
Sources

Summaries for Microscopic Colitis

About this section
Disease Ontology : 12 A colitis that can only be diagnosed by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to colitis and crohn's disease. An important gene associated with Microscopic Colitis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. The drugs Mesalamine and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and liver, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 74 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

Sources

Related Diseases for Microscopic Colitis

About this section

Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 561)
# Related Disease Score Top Affiliating Genes
1 colitis 31.7 TNF IL6 IL4 IL2 IFNG HLA-DRB1
2 crohn's disease 31.7 TNF IL6 IL4 IL2 IFNG HLA-DRB1
3 diarrhea 31.1 TNF TGM2 SLC6A4 IL6 IL2 IFNG
4 lymphocytic colitis 31.1 TOR1A TNF TGM2 ATP4A ATP12A
5 irritable bowel syndrome 30.8 TNF TGM2 SLC6A4 IL6 IL4
6 ulcerative colitis 30.6 TNF IL6 IL4 IL2 IFNG HLA-DRB1
7 gastroenteritis 30.4 TNF IL6 IL4 IFNG
8 crohn's colitis 30.3 TNF IL2 IFNG
9 inflammatory bowel disease 30.3 TNF IL6 IL4 IL2 IL15 IFNG
10 esophagitis 30.2 TNF IL6 IL4
11 spondylitis 30.0 TNF IL6 IFNG
12 constipation 30.0 SLC6A4 LOC110806262 IL6 ATP4A ATP12A
13 refractory celiac disease 30.0 IL15 IFNG HLA-DQB1
14 bacterial infectious disease 30.0 TNF IL6 IL15 IFNG
15 bullous pemphigoid 29.9 TNF IL4 HLA-DRB1 HLA-DQB1
16 cholera 29.9 TNF IL6 IL4 CD79A
17 pemphigoid 29.9 TNF IL4 IFNG HLA-DQB1
18 thyroiditis 29.9 TNF IL6 IL4 IL2 IFNG HLA-DRB1
19 uveitis 29.8 TNF IL6 IL4 IL2 IFNG
20 lung disease 29.7 TNF IL6 IL4 IL15 IFNG
21 graft-versus-host disease 29.6 TNF IL6 IL2 IFNG HLA-DRB1 HLA-DQB1
22 dermatitis herpetiformis 29.4 TNF TGM2 IL4 HLA-DQB1 CD79A
23 bone resorption disease 29.4 TNF IL6 ATP4A ATP12A
24 autoimmune disease 29.4 TNF TGM2 IL6 IL4 IL2 IL15
25 eye disease 29.4 TNF MIR126 IL6 IL4 IL2 IFNG
26 lymphocytic gastritis 29.3 TOR1A ATP4A ATP12A
27 osteoporosis 29.2 TNF TGM2 IL6 IL4 IL2 IFNG
28 tropical sprue 28.9 TOR1A TGM2 ATP4A ATP12A
29 celiac disease 1 28.1 TOR1A TNF TGM2 IL6 IL4 IL2
30 collagenous colitis 11.7
31 external pathological resorption 10.5 TNF IL6
32 scorpion envenomation 10.4 TNF IL6
33 physiological polycythemia 10.4 TNF IL6
34 tropical endomyocardial fibrosis 10.4 TNF IL4
35 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.4 IL4 IL2
36 idiopathic anterior uveitis 10.4 TNF IL6
37 limbic encephalitis with lgi1 antibodies 10.4 HLA-DRB1 HLA-DQB1
38 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
39 autoimmune polyglandular syndrome type 3 10.4 HLA-DRB1 HLA-DQB1
40 staphylococcal toxic shock syndrome 10.4 TNF IFNG
41 virus associated hemophagocytic syndrome 10.4 IL4 IL2
42 autoimmune myocarditis 10.4 TNF IFNG
43 cardiogenic shock 10.4 TNF IL6
44 hypersomnia 10.4 HLA-DRB1 HLA-DQB1
45 narcolepsy 2 10.4 HLA-DRB1 HLA-DQB1
46 toxicodendron dermatitis 10.4 TNF IL2
47 spotted fever rickettsiosis 10.4 TNF IFNG
48 polyarticular juvenile idiopathic arthritis 10.4 TNF IFNG
49 systemic onset juvenile idiopathic arthritis 10.4 TNF IL6 HLA-DRB1
50 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis
Sources

Symptoms & Phenotypes for Microscopic Colitis

About this section

MGI Mouse Phenotypes related to Microscopic Colitis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.27 ATP12A ATP4A HLA-DQB1 IFNG IL15 IL2
2 hematopoietic system MP:0005397 10.25 ATP4A CD79A HLA-DQB1 IFNG IL15 IL2
3 homeostasis/metabolism MP:0005376 10.25 ATP12A ATP4A CD79A HLA-DQB1 IFNG IL2
4 endocrine/exocrine gland MP:0005379 10.22 ATP4A HLA-DQB1 IFNG IL15 IL2 IL4
5 digestive/alimentary MP:0005381 10.19 ATP12A ATP4A HLA-DQB1 IFNG IL2 IL4
6 immune system MP:0005387 10.18 ATP4A CD79A HLA-DQB1 IFNG IL15 IL2
7 liver/biliary system MP:0005370 9.92 CD79A HLA-DQB1 IFNG IL2 IL4 IL6
8 neoplasm MP:0002006 9.86 ATP4A CD79A IFNG IL2 IL6 LYZ
9 no phenotypic analysis MP:0003012 9.7 CD79A IFNG IL2 IL4 LYZ TGM2
10 renal/urinary system MP:0005367 9.65 ATP12A CD79A HLA-DQB1 IFNG IL15 IL4
11 respiratory system MP:0005388 9.23 HLA-DQB1 IFNG IL2 IL4 IL6 LYZ
Sources

Drugs & Therapeutics for Microscopic Colitis

About this section

Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mesalamine Phase 2, Phase 3 89-57-6
2 Analgesics, Non-Narcotic Phase 2, Phase 3
3 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
4 Antirheumatic Agents Phase 2, Phase 3
5 Analgesics Phase 2, Phase 3
6
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173 46783403
7 Anti-Infective Agents Phase 2
8 Anti-Bacterial Agents Phase 2
9
Budesonide Approved 51333-22-3 63006 5281004
10 Pharmaceutical Solutions
11 Cola
12 Respiratory System Agents
13 Anti-Asthmatic Agents
14 Anti-Inflammatory Agents
15 Hormones
16 Hormone Antagonists
17 glucocorticoids
18 Bronchodilator Agents
19 Gastrointestinal Agents
20 Antacids
21 Anti-Ulcer Agents
22
Bismuth 7440-69-9 16682734 105143

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Budesonide for Treatment of Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
2 Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Randomised, Double-blind, Placebo-controlled, Multi-centre Trial on the Efficacy and Safety of Budesonide for Induction of Remission in Incomplete Microscopic Colitis Completed NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
4 A Randomized, Dose Ranging Trial of Mesalmine for the Treatment of Active Microscopic Colitis. Completed NCT00952952 Phase 2, Phase 3 Mesalamine
5 Efficacy and Safety of Oral Rifaximin in Patients With Active Microscopic Colitis Recruiting NCT04043897 Phase 2 Rifaximin 550mg
6 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
7 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
8 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
9 Ex Vivo Experiments to Evaluate the Role of Medication on the Colon Permeability in Microscopic Colitis Completed NCT02303132
10 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Completed NCT03275467
11 Risk Factors for Microscopic Colitis Recruiting NCT02699333
12 Identification and Characterization of Microbial and Immunologic Changes in Microscopic Colitis Recruiting NCT03063957
13 Faecal Transplantation in Inflammatory Bowel Disease Recruiting NCT03477032
14 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

Sources

Genetic Tests for Microscopic Colitis

About this section
Sources

Anatomical Context for Microscopic Colitis

About this section

MalaCards organs/tissues related to Microscopic Colitis:

40
Colon, Bone, Liver, Bone Marrow, Small Intestine, Thyroid, T Cells
Sources

Publications for Microscopic Colitis

About this section

Articles related to Microscopic Colitis:

(show top 50) (show all 840)
# Title Authors PMID Year
1
Comorbid Occurrence of Eosinophilic Esophagitis and Inflammatory Bowel Disease. 61
32068153 2021
2
Serum 7-alfa-hydroxy-4-cholesten-3-one and fibroblast growth factor-19 as biomarkers diagnosing bile acid malabsorption in microscopic colitis and inflammatory bowel disease. 61
33177381 2021
3
Intestinal Alkaline Phosphatase Combined with Voluntary Physical Activity Alleviates Experimental Colitis in Obese Mice. Involvement of Oxidative Stress, Myokines, Adipokines and Proinflammatory Biomarkers. 61
33557311 2021
4
The overlap between irritable bowel syndrome and organic gastrointestinal diseases. 61
33189181 2021
5
Isolated gastric Kaposi's sarcoma in a non-AIDS/HIV patient with coexisting collagenous gastritis and microscopic colitis. 61
33535738 2021
6
Authors' Response: Interpretations of Trends in Incidence of Microscopic Colitis. 61
33367673 2021
7
Bile Acid Sequestrant Therapy in Microscopic Colitis. 61
33443968 2021
8
The significance of histological activity measurements in immune checkpoint inhibitor colitis. 61
33146440 2021
9
Course of disease in patients with microscopic colitis - a European prospective incident cohort study. 61
33433605 2021
10
Epidemiology and seasonal pattern in hospitalizations for microscopic colitis. 61
33259385 2021
11
Microscopic colitis: a guide for general practice. 61
33372097 2021
12
Distribution of histopathological features along the colon in microscopic colitis. 61
32920702 2021
13
The patient with irritable bowel syndrome-type symptoms: when to investigate and how? 61
33027089 2021
14
IL-17 Inhibitors and Inflammatory Bowel Diseases: A Postmarketing Study in Vigibase. 61
33411953 2021
15
Gastrointestinal Infection and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden. 61
33421519 2021
16
High genetic diversity in Campylobacter concisus isolates from patients with microscopic colitis. 61
33436056 2021
17
Is There a Role for Bismuth in Diarrhea Management? 61
33064636 2021
18
Random colonic biopsies in macroscopically normal colonoscopies: is there any benefit? A two-centre audit of current practice. 61
32856361 2020
19
Fecal calprotectin in the pediatric population: a 2020 update. 61
32731735 2020
20
Faecal microbiota transfer in patients with microscopic colitis - a pilot study in collagenous colitis. 61
33142068 2020
21
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up. 61
32991931 2020
22
Anti-PD-1 induced collagenous colitis in metastatic melanoma: a rare severe adverse event. 61
32404733 2020
23
Association of Chronic Immune-Mediated Diarrhea and Colitis With Favorable Cancer Response. 61
33316767 2020
24
P054 Utilization of Biologic Therapy in Patients With Microscopic Colitis Not Responding to Standard Therapy. 61
33566528 2020
25
Visible or invisible atypical form of microscopic colitis with giant cells: for the endoscopist, that is the question. 61
32303078 2020
26
Interpretations of trends in incidence of microscopic colitis. 61
33155640 2020
27
High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study. 61
32111632 2020
28
Lymphocytic Colitis With Increased Apoptosis: A Marker of Mutation in T-Cell-Mediated Immunity? 61
32955408 2020
29
Epidemiological and clinical characteristics, and response to treatment in 113 patients with microscopic colitis. 61
33248178 2020
30
Safety profile of vonoprazan compared with proton pump inhibitors: insight from a pharmacovigilance study. 61
33305731 2020
31
Disease activity patterns, mortality and colorectal cancer risk in microscopic colitis: a Danish nationwide cohort study, 2001 to 2016. 61
33049029 2020
32
Microscopic Colitis Is Not an Independent Risk Factor for Low Bone Density. 61
33063187 2020
33
Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study. 61
33129712 2020
34
AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis and Hepatitis: Expert Review. 61
33080231 2020
35
Colitis nucleomigrans: The third type of microscopic colitis (part 1). 61
32761850 2020
36
Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats. 61
32924710 2020
37
Mortality of Patients With Microscopic Colitis in Sweden. 61
31857243 2020
38
Overview of microscopic colitis. 61
33135914 2020
39
Irritable bowel syndrome-like symptoms in treated microscopic colitis patients compared with controls: a cross-sectional study. 61
33163193 2020
40
Increasing Incidence of Microscopic Colitis in a Population-Based Cohort Study in Switzerland. 61
33065310 2020
41
Colitis nucleomigrans: The third type of microscopic colitis (part 2). An ultrastructural study. 61
32761883 2020
42
Cannabidiol Oil-Associated Microscopic Colitis. 61
33094069 2020
43
Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies. 61
32673680 2020
44
Safety of Immune Checkpoint Inhibitors in Patients With Pre-Existing Inflammatory Bowel Disease and Microscopic Colitis. 61
32401685 2020
45
High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. 61
32954237 2020
46
The Role of Resilience in Irritable Bowel Syndrome, Other Chronic Gastrointestinal Conditions, and the General Population. 61
32835842 2020
47
Collagenous colitis in a child induced by chronic respiratory allergy: A case report. 61
32871927 2020
48
Diagnostic Yield of Colonoscopy in Patients With Symptoms Compatible With Rome IV Functional Bowel Disorders. 61
32882424 2020
49
European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations. 61
32819215 2020
50
Successful use of beclometasone dipropionate for the treatment of microscopic colitis. 61
32448057 2020
Sources

Variations for Microscopic Colitis

About this section
Sources

Expression for Microscopic Colitis

About this section
Search GEO for disease gene expression data for Microscopic Colitis.
Sources

Pathways for Microscopic Colitis

About this section

Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.35 TNF IL6 IL4 IL2 IL15 IFNG
2
IL-2 Pathway 63
Show member pathways
 13.21 TNF IL4 IL2 IFNG HLA-DRB1 HLA-DQB1
3
Measles 36
Show member pathways
 12.82 TNF IL6 IL2 IFNG HLA-DRB1 HLA-DQB1
4
Herpes simplex virus 1 infection 36
12.8 TNF IL6 IFNG HLA-DRB1 HLA-DQB1
5
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 64
Show member pathways
 12.77 TNF IL6 IL4 IL2 IL15
6
Allograft rejection 36 1
Show member pathways
 12.67 TNF IL6 IL4 IL2 IL15 IFNG
7
T cell receptor signaling pathway 36
Show member pathways
 12.59 TNF IL6 IL4 IL2 IFNG
8
Immune response NFAT in immune response 23
Show member pathways
 12.58 TNF IL4 IL2 IFNG HLA-DRB1 HLA-DQB1
9
NF-kappaB Signaling 4
12.56 TNF IL4 IL2 IFNG CD79A
10
Th17 cell differentiation 36
Show member pathways
 12.49 TNF IL6 IL4 IL2 IFNG HLA-DRB1
11
JAK-STAT signaling pathway 36
Show member pathways
 12.41 IL6 IL4 IL2 IL15 IFNG
12
Folate Metabolism 1
Show member pathways
 12.34 TNF IL6 IL4 IL2 IFNG
13
IL-17 Family Signaling Pathways 64
Show member pathways
 12.33 TNF IL6 IL4 IFNG
14
Human T-cell leukemia virus 1 infection 36
12.27 TNF IL6 IL2 IL15 HLA-DRB1 HLA-DQB1
15
Toxoplasmosis 36
Show member pathways
 12.24 TNF IL4 IFNG HLA-DRB1 HLA-DQB1
16
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.23 TNF IL6 IL4 IL2 IL15 IFNG
17
Tuberculosis 36
12.21 TNF IL6 IFNG HLA-DRB1 HLA-DQB1
18
Bacterial infections in CF airways 23
Show member pathways
 12.19 TNF IL6 IL4 IFNG
19
Spinal Cord Injury 1
11.99 TNF IL6 IL4 IL2 IFNG
20
IL12-mediated signaling events 1
Show member pathways
 11.98 IL4 IL2 IFNG HLA-DRB1
21
Hematopoietic cell lineage 36
11.83 TNF IL6 IL4 HLA-DRB1 HLA-DQB1
22
Glucocorticoid receptor regulatory network 1
11.81 IL6 IL4 IL2 IFNG
23
Th1 Differentiation Pathway 64
Show member pathways
 11.77 TNF IL6 IL2 IFNG
24
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 TNF IL4 IL2 IFNG
25
Dendritic Cells Developmental Lineage Pathway 64
11.75 TNF IL6 IL2 IFNG
26
Commom Cytokine Receptor G Chain Siganaling Pathway 66
11.73 IL4 IL2 IL15
27
Rheumatoid arthritis 36
11.7 TNF IL6 IL15 IFNG HLA-DRB1 HLA-DQB1
28
IgA-Producing B Cells in the Intestine 64
11.68 TNF IL6 IL4
29
Innate Lymphoid Cell Differentiation Pathways 64
11.67 TNF IL4 IL2 IL15 IFNG
30
Lung fibrosis 1
11.66 TNF IL6 IL4
31
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.64 TNF IL2 IFNG
32
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.64 TNF IL6 IL2 IFNG
33
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.56 TNF IL6 IL4 IL2 IL15 IFNG
34
Malaria 36
11.55 TNF IL6 IFNG
35
Interleukin-10 signaling 65
11.54 TNF IL6 IL4
36
Photodynamic therapy-induced AP-1 survival signaling. 1
11.53 TNF IL6 IL2 IFNG
37
Aryl Hydrocarbon Receptor Pathway 1
11.52 TNF IL2 IFNG
38
Th2 Differentiation Pathway 64
11.5 IL4 IL2 IFNG
39
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.49 TNF IL6 IFNG
40
African trypanosomiasis 36
11.39 TNF IL6 IFNG
41
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.35 TNF IL2 IL15 IFNG
42
Inflammatory Response Pathway 1
11.33 IL4 IL2 IFNG
43
IL12 signaling mediated by STAT4 1
11.25 IL2 IFNG HLA-DRB1
44
OX40 Pathway 63
11.21 IL4 IL2 IFNG
45
Development and heterogeneity of the ILC family 1
11.06 TNF IL6 IL4 IL15 IFNG
46
EV release from cardiac cells and their functional effects 1
10.65 TNF MIR126
47
Cytokines and Inflammatory Response 1
10.63 TNF IL6 IL4 IL2 IL15 IFNG
Sources

GO Terms for Microscopic Colitis

About this section

Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 TNF MR1 MIR126 LYZ IL6 IL4

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.05 TNF SLC6A4 IL6 IL4 IFNG
2 adaptive immune response GO:0002250 10.04 IL2 IFNG HLA-DRB1 HLA-DQB1 CD79A
3 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL2 IFNG HLA-DRB1
4 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IFNG
5 interferon-gamma-mediated signaling pathway GO:0060333 9.82 IFNG HLA-DRB1 HLA-DQB1
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 TNF TGM2 IL6
7 humoral immune response GO:0006959 9.78 TNF IL6 IFNG
8 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF IL6 IFNG
9 positive regulation of cytokine production GO:0001819 9.77 TNF IL15 IFNG
10 defense response to Gram-positive bacterium GO:0050830 9.76 TNF MR1 LYZ IL6
11 positive regulation of phagocytosis GO:0050766 9.71 TNF IL15 IFNG
12 positive regulation of chemokine production GO:0032722 9.7 TNF IL6 IFNG
13 negative regulation of amyloid-beta clearance GO:1900222 9.66 TNF IFNG
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.66 IL4 IFNG
15 microglial cell activation GO:0001774 9.65 TNF IL4 IFNG
16 negative regulation of T-helper 17 cell differentiation GO:2000320 9.64 IL4 IL2
17 positive regulation of isotype switching to IgG isotypes GO:0048304 9.63 IL4 IL2
18 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
19 positive regulation of inflammatory response GO:0050729 9.63 TNF TGM2 MIR126 IL2 IL15 IFNG
20 vascular endothelial growth factor production GO:0010573 9.61 TNF IL6
21 immune response GO:0006955 9.61 TNF MR1 IL6 IL4 IL2 IL15
22 positive regulation of mononuclear cell migration GO:0071677 9.58 TNF IL4
23 positive regulation of tissue remodeling GO:0034105 9.58 IL2 IL15
24 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.57 HLA-DRB1 HLA-DQB1
25 positive regulation of cellular respiration GO:1901857 9.56 IL4 IFNG
26 positive regulation of T cell proliferation GO:0042102 9.56 IL6 IL4 IL2 IL15
27 neuroinflammatory response GO:0150076 9.55 IL4 IFNG
28 macrophage differentiation GO:0030225 9.54 IL15 IFNG HLA-DRB1
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IFNG
30 positive regulation of interleukin-17 production GO:0032740 9.5 IL6 IL2 IL15
31 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.49 HLA-DRB1 HLA-DQB1
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 TNF IFNG
33 positive regulation of nitrogen compound metabolic process GO:0051173 9.4 TNF IFNG
34 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.1 TNF IL6 IL4 IL2 IL15 IFNG

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor binding GO:0042608 9.37 MR1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 9.32 HLA-DRB1 HLA-DQB1
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
5 cytokine activity GO:0005125 9.1 TNF IL6 IL4 IL2 IL15 IFNG
6 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
Sources

Sources for Microscopic Colitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....