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MCID: MCR191
MIFTS: 48

Microscopic Colitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Microscopic Colitis

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MalaCards integrated aliases for Microscopic Colitis:

Name: Microscopic Colitis 12 15
Colitis, Microscopic 44 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060182
MeSH 44 D046728
NCIt 50 C38504
SNOMED-CT 68 235753003
UMLS 73 C0400821
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Summaries for Microscopic Colitis

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Disease Ontology : 12 A colitis that can only be diagnosed_by the examination of colon tissue under a microscope.

MalaCards based summary : Microscopic Colitis, also known as colitis, microscopic, is related to lymphocytic colitis and duodenitis. An important gene associated with Microscopic Colitis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Budesonide and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis... more...

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Related Diseases for Microscopic Colitis

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Diseases related to Microscopic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 33.0 ATP12A CD79A
2 duodenitis 30.4 ATP12A CD79A
3 ulcerative colitis 29.8 IL2 IL6 TNF
4 celiac disease 1 29.6 CD79A IFNG IL2 TNF
5 colitis 29.5 IFNG IL2 IL4 IL6 TNF
6 inflammatory bowel disease 27.9 HLA-DRB1 IFNG IL2 IL4 IL6 TNF
7 diabetes mellitus 27.8 HLA-DRB1 IFNG IL2 IL6 TNF
8 collagenous colitis 11.9
9 microscopic polyangiitis 10.8 HLA-DRB1 TNF
10 beryllium disease 10.8 HLA-DRB1 TNF
11 autoimmune pancreatitis 10.8 HLA-DRB1 TNF
12 lichen sclerosus 10.8 HLA-DRB1 TNF
13 actinic prurigo 10.7 HLA-DRB1 TNF
14 oral tuberculosis 10.7 IL2 TNF
15 sympathetic ophthalmia 10.7 HLA-DRB1 TNF
16 recurrent respiratory papillomatosis 10.7 HLA-DRB1 IL2
17 nontuberculous mycobacterial lung disease 10.7 HLA-DRB1 TNF
18 tropical endomyocardial fibrosis 10.6 IL4 TNF
19 rheumatoid vasculitis 10.6 HLA-DRB1 TNF
20 immunoglobulin a deficiency 1 10.6 CD79A IL4
21 trichomoniasis 10.6 CD79A IL2
22 tungiasis 10.6 IL4 TNF
23 endomyocardial fibrosis 10.6 IL4 TNF
24 congenital hypogammaglobulinemia 10.6 CD79A IL4
25 parasitic ichthyosporea infectious disease 10.6 CD79A IL4
26 chronic pulmonary heart disease 10.6 SLC6A4 TNF
27 rhinosporidiosis 10.6 CD79A IL4
28 neuroschistosomiasis 10.6 CD79A IFNG
29 cervicitis 10.6 CD79A IL2
30 scleritis 10.6 IL4 TNF
31 staphylococcal toxic shock syndrome 10.5 IFNG TNF
32 sporotrichosis 10.5 CD79A IFNG
33 geographic tongue 10.5 CD79A HLA-DRB1 TNF
34 immunodeficiency with hyper-igm, type 1 10.5 CD79A IL4
35 virus associated hemophagocytic syndrome 10.5 IL2 IL4
36 trichosporonosis 10.5 IFNG TNF
37 eosinophilia-myalgia syndrome 10.5 HLA-DRB1 IFNG
38 strongyloidiasis 10.5 CD79A IFNG
39 chronic graft versus host disease 10.5 CD79A IFNG
40 gastrointestinal allergy 10.5 CD79A IL4
41 jak3-deficient severe combined immunodeficiency 10.5 IL2 IL4
42 scorpion envenomation 10.5 IL6 TNF
43 angiostrongyliasis 10.4 IL2 IL4
44 variola major 10.4 IFNG IL2
45 leukomalacia 10.4 IL6 TNF
46 mycoplasmal pneumonia 10.4 IFNG IL4
47 gestational choriocarcinoma 10.4 IFNG SLC6A4
48 fixed drug eruption 10.4 IFNG IL2
49 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
50 polyclonal hypergammaglobulinemia 10.4 CD79A IL6

Graphical network of the top 20 diseases related to Microscopic Colitis:



Diseases related to Microscopic Colitis
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Symptoms & Phenotypes for Microscopic Colitis

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GenomeRNAi Phenotypes related to Microscopic Colitis according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.47 IL4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.47 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.47 SLC6A4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.47 CD79A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.47 IL4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.47 SLC6A4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.47 SLC6A4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.47 IL4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 CD79A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.47 CD79A IL4 SLC6A4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 CD79A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.47 SLC6A4

MGI Mouse Phenotypes related to Microscopic Colitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.09 IFNG IL6 IL2 ATP12A CD79A IL4
2 growth/size/body region MP:0005378 10.08 IFNG IL6 ATP12A IL2 IL4 SLC6A4
3 hematopoietic system MP:0005397 10.06 IFNG IL6 IL2 CD79A IL4 TNF
4 digestive/alimentary MP:0005381 10.05 IL6 IL2 ATP12A IL4 IFNG TNF
5 endocrine/exocrine gland MP:0005379 10.04 IFNG IL6 IL2 IL4 TNF LYZ
6 immune system MP:0005387 10.01 IFNG IL6 IL2 CD79A IL4 TNF
7 liver/biliary system MP:0005370 9.87 IL6 IL2 LYZ CD79A IL4 IFNG
8 integument MP:0010771 9.85 IFNG IL6 IL4 TNF LYZ SLC6A4
9 neoplasm MP:0002006 9.73 IL6 IL2 CD79A IFNG TNF LYZ
10 no phenotypic analysis MP:0003012 9.63 IFNG IL2 CD79A IL4 TNF LYZ
11 renal/urinary system MP:0005367 9.43 IL6 ATP12A CD79A IL4 IFNG LYZ
12 respiratory system MP:0005388 9.1 IFNG IL6 IL2 IL4 TNF LYZ
Sources

Drugs & Therapeutics for Microscopic Colitis

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Drugs for Microscopic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Phase 2,Not Applicable 51333-22-3 63006 5281004
2 Anti-Asthmatic Agents Phase 3,Phase 2,Not Applicable
3 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
4 Autonomic Agents Phase 3,Phase 2,Not Applicable
5 Bronchodilator Agents Phase 3,Phase 2,Not Applicable
6 glucocorticoids Phase 3,Phase 2,Not Applicable
7 Hormone Antagonists Phase 3,Phase 2,Not Applicable
8 Hormones Phase 3,Phase 2,Not Applicable
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
10 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
11 Respiratory System Agents Phase 3,Phase 2,Not Applicable
12 Analgesics Phase 2, Phase 3,Phase 3
13 Analgesics, Non-Narcotic Phase 2, Phase 3,Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Phase 3
15 Antirheumatic Agents Phase 2, Phase 3,Phase 3
16 Mesalamine Phase 2, Phase 3,Phase 3 89-57-6
17 Pharmaceutical Solutions Not Applicable
18 Antacids Not Applicable
19 Anti-Ulcer Agents Not Applicable
20
Bismuth Not Applicable 7440-69-9 16682734 105143
21 Gastrointestinal Agents Not Applicable
22 Cola Nutraceutical Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
2 Trial of Mesalamine for the Treatment of Active Microscopic Colitis Completed NCT00952952 Phase 2, Phase 3 Mesalamine
3 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
4 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
5 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3 Budesonide;Placebo
6 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Completed NCT01209208 Phase 3 Budesonide;Mesalamine
7 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
8 Budesonide for Induction of Remission in Incomplete Microscopic Colitis Recruiting NCT02142634 Phase 3 Budesonide granules 9 mg;Placebo granules
9 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
10 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
11 Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS) Unknown status NCT01787253
12 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy Unknown status NCT02284802 Not Applicable
13 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
14 Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis Completed NCT02303132 Not Applicable
15 Risk Factors for Microscopic Colitis Recruiting NCT02699333
16 Identification/Characterization of Changes in Microscopic Colitis Recruiting NCT03063957
17 Fecal Microbiota Transplantation for C Diff Infection Recruiting NCT01905709 Not Applicable
18 Faecal Microbiota Transplantation in Patients With Microscopic Colitis Enrolling by invitation NCT03275467 Not Applicable
19 FMT in Inflammatory Bowel Disease Not yet recruiting NCT03477032
20 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Microscopic Colitis

Cochrane evidence based reviews: colitis, microscopic

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Genetic Tests for Microscopic Colitis

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Anatomical Context for Microscopic Colitis

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MalaCards organs/tissues related to Microscopic Colitis:

41
Colon, T Cells, Thyroid, Bone, Small Intestine
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Publications for Microscopic Colitis

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Articles related to Microscopic Colitis:

(show top 50) (show all 347)
# Title Authors Year
1
Decreased risk for microscopic colitis and inflammatory bowel disease among patients with reflux disease. ( 29603881 )
2018
2
Microscopic colitis-microbiome, barrier function and associated diseases. ( 29610731 )
2018
3
Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. ( 29852792 )
2018
4
Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. ( 29370359 )
2018
5
The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. ( 29610757 )
2018
6
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. ( 29742325 )
2018
7
Pembrolizumab-Induced Microscopic Colitis. ( 29610496 )
2018
8
Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )
2018
9
High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. ( 29977339 )
2018
10
Risk of osteoporosis in microscopic colitis. ( 29460653 )
2018
11
Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. ( 29204743 )
2018
12
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. ( 29535059 )
2018
13
Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. ( 29546806 )
2018
14
Microscopic Colitis: A Rare Cause of Pseudomembranes. ( 29981436 )
2018
15
Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis. ( 29457048 )
2018
16
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. ( 28669150 )
2017
17
Microscopic Colitis: A Review of Collagenous and Lymphocytic Colitis. ( 29230146 )
2017
18
Letter: the definition of budesonide dependence in microscopic colitis-authors' reply. ( 28805323 )
2017
19
Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318707 )
2017
20
Endoscopic features of microscopic colitis: The "grid-like" pattern detected with HD+ colonoscopy plus i-scan. ( 28174001 )
2017
21
Continuing Medical Education: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050030 )
2017
22
Endoscopic findings and colonic perforation in microscopic colitis: A systematic review. ( 28847471 )
2017
23
Th1 Pathway: The Missing Link Between Inflammatory Bowel Disease and Microscopic Colitis? ( 28776143 )
2017
24
Macroscopic findings, incidence and characteristics of microscopic colitis in a large cohort of patients from the United Kingdom. ( 28562114 )
2017
25
Is Epstein-Barr virus infection associated with the pathogenesis of microscopic colitis? ( 29078077 )
2017
26
Continuing Medical Education Questions: January 2017: Diagnosis and Management of Microscopic Colitis. ( 28050038 )
2017
27
Extended-release Multimatrix Budesonide for Microscopic Colitis. ( 28328627 )
2017
28
Early Life Exposure, Lifestyle, and Comorbidity as Risk Factors for Microscopic Colitis: A Case-Control Study. ( 28471835 )
2017
29
Symptomatic Microscopic Colitis Atop Quiescent Inflammatory Bowel Disease: A Case Series. ( 29299484 )
2017
30
Antidepressant-Associated Microscopic Colitis: A Case Report and Literature Review. ( 28347506 )
2017
31
Case report: Pentoxifylline treatment in microscopic colitis. ( 29145246 )
2017
32
Diagnosis and Management of Microscopic Colitis. ( 27897155 )
2017
33
Microscopic Colitis After Fecal Microbiota Transplant. ( 28761890 )
2017
34
Letter: the definition of budesonide dependence in microscopic colitis. ( 28805319 )
2017
35
Over 90% of cases of Microscopic Colitis can be diagnosed by performing a short colonoscopy. ( 28215538 )
2017
36
Immune modulator therapy for microscopic colitis in a case series of 73 patients. ( 28488312 )
2017
37
Biomarkers and Microscopic Colitis: An Unmet Need in Clinical Practice. ( 28540290 )
2017
38
Medical Treatment for Microscopic Colitis: A Community Hospital's Experience. ( 29317939 )
2017
39
Family history, comorbidity, smoking and other risk factors in microscopic colitis: a case-control study. ( 28350750 )
2017
40
Microscopic Colitis Evolved Into Inflammatory Bowel Diseases Is Characterized by Increased Th1/Tc1 Cells in Colonic Mucosal Lamina Propria. ( 28597107 )
2017
41
Microscopic colitis: a missed diagnosis among patients with moderate to severe irritable bowel syndrome. ( 27796144 )
2017
42
Answer to Carmona R.: Are the anti-CdtB and anti-vinculin antibodies really ready for use in patients with diarrhea in Mexico? Regarding microscopic colitis. ( 28318705 )
2017
43
Oligoclonal T-cell Receptor Repertoire in Colonic Biopsies of Patients with Microscopic Colitis and Ulcerative Colitis. ( 28498152 )
2017
44
Interaction of Ethnicity and H. pylori Infection in the Occurrence of Microscopic Colitis. ( 28070826 )
2017
45
Current Approach to the Evaluation and Management of Microscopic Colitis. ( 28265892 )
2017
46
Incidence, Clinical Presentation, and Associated Factors of Microscopic Colitis in Northern France: A Population-Based Study. ( 27659673 )
2016
47
American Gastroenterological Association Institute Guideline on the Medical Management of Microscopic Colitis. ( 26584605 )
2016
48
Current concepts on microscopic colitis: evidence-based statements and recommendations of the Spanish Microscopic Colitis Group. ( 26597122 )
2016
49
The association between the intake of specific dietary components and lifestyle factors and microscopic colitis. ( 27460269 )
2016
50
High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. ( 26956016 )
2016
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Variations for Microscopic Colitis

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Expression for Microscopic Colitis

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Search GEO for disease gene expression data for Microscopic Colitis.
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Pathways for Microscopic Colitis

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Pathways related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.9 CD79A HLA-DRB1 IFNG IL2 IL4 IL6
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.27 HLA-DRB1 IFNG IL2 IL4 IL6 TNF
3
Allograft rejection 1 37
Show member pathways
 12.79 HLA-DRB1 IFNG IL2 IL4 IL6 TNF
4
Pathways in cancer 37
12.74 IFNG IL2 IL4 IL6
5
IL-2 Pathway 64
Show member pathways
 12.74 CD79A IFNG IL2 IL4 TNF
6
Influenza A 37
Show member pathways
 12.62 HLA-DRB1 IFNG IL2 IL4 IL6 TNF
7
Regulation of IFNA signaling 66
Show member pathways
 12.56 IFNG IL2 IL4 IL6 TNF
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.52 IFNG IL2 IL6 TNF
9
NF-kappaB Signaling 4
12.5 CD79A IFNG IL2 IL4 TNF
10
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.46 IFNG IL2 IL4 TNF
11
HTLV-I infection 37
12.38 HLA-DRB1 IL2 IL6 TNF
12
T cell receptor signaling pathway 37
Show member pathways
 12.34 IFNG IL2 IL4 IL6 TNF
13
IL-17 Family Signaling Pathways 65
Show member pathways
 12.3 IFNG IL4 IL6 TNF
14
Th1 Differentiation Pathway 65
Show member pathways
 12.22 IFNG IL2 IL6 TNF
15
Toxoplasmosis 37
Show member pathways
 12.21 HLA-DRB1 IFNG IL4 TNF
16
Toll Comparative Pathway 64
Show member pathways
 12.18 IFNG IL6 TNF
17
Tuberculosis 37
12.18 HLA-DRB1 IFNG IL6 TNF
18
Folate Metabolism 1
Show member pathways
 12.16 IFNG IL2 IL4 IL6 TNF
19
Bacterial infections in CF airways 22
Show member pathways
 12.14 IFNG IL4 IL6 TNF
20
C-type lectin receptor signaling pathway 37
Show member pathways
 12.13 IL2 IL6 TNF
21
Colorectal Cancer Metastasis 64
12.1 IFNG IL6 TNF
22
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.09 IL6 SLC6A4 TNF
23
Th17 cell differentiation 37
Show member pathways
 12.05 HLA-DRB1 IFNG IL2 IL4 IL6 TNF
24
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.01 IFNG IL2 IL4 IL6
25
IL12-mediated signaling events 1
Show member pathways
 11.94 HLA-DRB1 IFNG IL2 IL4
26
Interleukin-4 and 13 signaling 66
11.92 IL4 IL6 TNF
27
Hematopoietic cell lineage 37
11.85 HLA-DRB1 IL4 IL6 TNF
28
Amoebiasis 37
11.84 IFNG IL6 TNF
29
Jak-Stat Signaling Pathway 67
11.82 IFNG IL2 IL6
30
Rheumatoid arthritis 37
11.8 HLA-DRB1 IFNG IL6 TNF
31
Spinal Cord Injury 1
11.8 IFNG IL2 IL4 IL6 TNF
32
Glucocorticoid receptor regulatory network 1
11.74 IFNG IL2 IL4 IL6
33
Innate Lymphoid Cell Differentiation Pathways 65
11.71 IFNG IL2 IL4 TNF
34
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.68 IFNG IL2 IL4 TNF
35
Lung fibrosis 1
11.65 IL4 IL6 TNF
36
Dendritic Cells Developmental Lineage Pathway 65
11.65 IFNG IL2 IL6 TNF
37
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.63 IFNG IL2 TNF
38
Interleukin-10 signaling 66
11.52 IL4 IL6 TNF
39
Malaria 37
11.52 IFNG IL6 TNF
40
Aryl Hydrocarbon Receptor Pathway 1
11.51 IFNG IL2 TNF
41
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 IFNG IL2 IL6 TNF
42
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.5 CD79A IFNG IL2 IL4 IL6 TNF
43
Th2 Differentiation Pathway 65
11.49 IFNG IL2 IL4
44
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.46 IFNG IL6 TNF
45
Photodynamic therapy-induced AP-1 survival signaling. 1
11.38 IFNG IL2 IL6 TNF
46
African trypanosomiasis 37
11.34 IFNG IL6 TNF
47
Inflammatory Response Pathway 1
11.31 IFNG IL2 IL4
48
IL12 signaling mediated by STAT4 1
11.23 HLA-DRB1 IFNG IL2
49
OX40 Pathway 64
11.19 IFNG IL2 IL4
50
Development and heterogeneity of the ILC family 1
11.06 IFNG IL4 IL6 TNF
Sources

GO Terms for Microscopic Colitis

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Cellular components related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 IFNG IL2 IL4 IL6 LYZ TNF
2 extracellular region GO:0005576 9.17 IFNG IL2 IL4 IL6 LYZ MR1

Biological processes related to Microscopic Colitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.91 CD79A HLA-DRB1 IL2 MR1
2 positive regulation of gene expression GO:0010628 9.84 IFNG IL6 SLC6A4 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.8 IL2 IL4 IL6 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.77 IFNG IL2 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.69 IL6 LYZ TNF
6 defense response to Gram-negative bacterium GO:0050829 9.65 IL6 LYZ MR1
7 regulation of signaling receptor activity GO:0010469 9.65 IFNG IL2 IL4 IL6 TNF
8 protein import into nucleus, translocation GO:0000060 9.61 IFNG TNF
9 positive regulation of protein complex assembly GO:0031334 9.6 IFNG TNF
10 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG TNF
11 positive regulation of chemokine production GO:0032722 9.58 IL6 TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL2 IL6
13 positive regulation of T cell differentiation GO:0045582 9.57 IL2 IL4
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.56 IFNG TNF
15 regulation of regulatory T cell differentiation GO:0045589 9.55 IFNG IL2
16 positive regulation of T cell proliferation GO:0042102 9.54 IL2 IL4 IL6
17 positive regulation of immunoglobulin secretion GO:0051024 9.52 IL2 IL6
18 humoral immune response GO:0006959 9.5 IFNG IL6 TNF
19 negative regulation of lipid storage GO:0010888 9.46 IL6 TNF
20 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IL2 IL4
21 immune response GO:0006955 9.17 HLA-DRB1 IFNG IL2 IL4 IL6 MR1
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
23 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF

Molecular functions related to Microscopic Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.02 IFNG IL2 IL4 IL6 TNF
Sources

Sources for Microscopic Colitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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