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MCID: MCR020
MIFTS: 44

Microsporidiosis

Categories: Immune diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Microsporidiosis

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MalaCards integrated aliases for Microsporidiosis:

Name: Microsporidiosis 12 77 54 60 56 45 15 17 74
Infection by Microsporida 12
Infection by Microsporea 12
Infection by Microspora 12
Microsporidiasis 54

Characteristics:

Orphanet epidemiological data:

60
microsporidiosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:4271
MeSH 45 D016881
NCIt 51 C84891
ICD10 34 B60.8
MESH via Orphanet 46 D016881
ICD10 via Orphanet 35 B60.8
UMLS via Orphanet 75 C0085407
Orphanet 60 ORPHA2552
UMLS 74 C0085407
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Summaries for Microsporidiosis

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Disease Ontology : 12 An opportunistic mycosis that results in systemic fungal infection in immunocompromised people, has material basis in Microsporidia phylum members.

MalaCards based summary : Microsporidiosis, also known as infection by microsporida, is related to encephalitozoonosis and diarrhea. An important gene associated with Microsporidiosis is METAP2 (Methionyl Aminopeptidase 2), and among its related pathways/superpathways are Doxorubicin Pathway, Pharmacokinetics and Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Emtricitabine and Tenofovir have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and small intestine.

Wikipedia : 77 Microsporidiosis is an opportunistic intestinal infection that causes diarrhea and wasting in... more...

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Related Diseases for Microsporidiosis

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Diseases related to Microsporidiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 encephalitozoonosis 11.5
2 diarrhea 10.5
3 acquired immunodeficiency syndrome 10.5
4 cryptosporidiosis 10.3
5 human immunodeficiency virus infectious disease 10.1
6 fatty liver disease, nonalcoholic 1 10.0
7 cyclosporiasis 10.0
8 cystoisosporiasis 10.0
9 colchicine resistance 10.0 ABCB1 ABCC1
10 oral candidiasis 9.9 DEFA1 DEFB4A
11 keratitis, hereditary 9.9
12 myositis 9.9
13 spondylocarpotarsal synostosis syndrome 9.9
14 human immunodeficiency virus type 1 9.9
15 malaria 9.9
16 leukemia 9.9
17 sleeping sickness 9.9
18 trypanosomiasis 9.9
19 meningoencephalitis 9.9
20 giardiasis 9.9
21 sarcoma 9.9
22 urethritis 9.9
23 sclerosing cholangitis 9.9
24 candidiasis 9.9
25 rheumatic disease 9.9
26 cholecystitis 9.9
27 acalculous cholecystitis 9.9
28 lymphopenia 9.9
29 conjunctivitis 9.9
30 progressive multifocal leukoencephalopathy 9.9
31 mucormycosis 9.9
32 myeloid sarcoma 9.9
33 leishmaniasis 9.9
34 cholangitis 9.9
35 irritable bowel syndrome 9.9
36 trypanosomiasis, human east-african 9.9
37 multidrug-resistant tuberculosis 9.9 ABCB1 DEFA1
38 vaginitis 9.9 ABCB1 DEFB4A
39 uterine sarcoma 9.9 ABCB1 ABCC1
40 cervix carcinoma 9.8 ABCB1 ABCC1
41 small cell cancer of the lung 9.7 ABCB1 ABCC1

Graphical network of the top 20 diseases related to Microsporidiosis:



Diseases related to Microsporidiosis
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Symptoms & Phenotypes for Microsporidiosis

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Drugs & Therapeutics for Microsporidiosis

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Drugs for Microsporidiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emtricitabine Approved, Investigational Phase 4,Phase 3 143491-57-0 60877
2
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 3 147127-20-6 464205
3
Zidovudine Approved Phase 4 30516-87-1 35370
4
Didanosine Approved Phase 4 69655-05-6 50599
5
Efavirenz Approved, Investigational Phase 4,Phase 3 154598-52-4 64139
6
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
7
Nevirapine Approved Phase 4,Phase 3 129618-40-2 4463
8
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
9 Atazanavir Sulfate Phase 4
10 Anti-Infective Agents Phase 4,Phase 3
11 Antiviral Agents Phase 4,Phase 3
12 Anti-HIV Agents Phase 4,Phase 3
13
protease inhibitors Phase 4,Phase 3
14 Anti-Retroviral Agents Phase 4,Phase 3
15 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3
16 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
17 Lamivudine, zidovudine drug combination Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
19 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 3
20 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 3
21 Reverse Transcriptase Inhibitors Phase 4,Phase 3
22 Antimetabolites Phase 4
23 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 4,Phase 3
24 HIV Protease Inhibitors Phase 4,Phase 3
25 Cytochrome P-450 CYP3A Inhibitors Phase 4
26
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
27
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
28
tannic acid Approved Phase 3 1401-55-4
29
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
30
Maraviroc Approved, Investigational Phase 3 376348-65-1 3002977
31
Fosamprenavir Approved Phase 3 226700-79-4 131536
32
Etoposide Approved Phase 3 33419-42-0 36462
33
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
34
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
35
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
36 Antimitotic Agents Phase 3
37 Antiparasitic Agents Phase 3
38 Anthelmintics Phase 3
39 Antiprotozoal Agents Phase 3
40 Analgesics, Non-Narcotic Phase 3
41 Peripheral Nervous System Agents Phase 3
42 Interleukin-2 Phase 3
43 Analgesics Phase 3
44 Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 3
45 Etoposide phosphate Phase 3
46 Antineoplastic Agents, Phytogenic Phase 3
47 Topoisomerase Inhibitors Phase 3
48 Anti-Bacterial Agents Phase 3
49 Integrase Inhibitors Phase 3
50 Albumin-Bound Paclitaxel Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited Settings Completed NCT00084136 Phase 4 Atazanavir;Didanosine (enteric-coated);Efavirenz;Emtricitabine;Emtricitabine/Tenofovir disoproxil fumarate;Lamivudine/Zidovudine
2 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
3 A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis Completed NCT00002191 Phase 3 Albendazole
4 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin
5 An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral Therapy Completed NCT00004978 Phase 3 Recombinant interleukin-2 (rIL-2)
6 Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Completed NCT01348308 Phase 3 Maraviroc (Celsentri);Placebo
7 Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS Active, not recruiting NCT01435018 Phase 3 Etoposide (ET);Bleomycin and Vincristine (BV);Paclitaxel (PTX);Co-formulated Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate (EFV/FTC/TDF)

Search NIH Clinical Center for Microsporidiosis

Cochrane evidence based reviews: microsporidiosis

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Genetic Tests for Microsporidiosis

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Anatomical Context for Microsporidiosis

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MalaCards organs/tissues related to Microsporidiosis:

42
Bone, Kidney, Small Intestine, Testes, Liver, Heart, Bone Marrow
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Publications for Microsporidiosis

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Articles related to Microsporidiosis:

(show top 50) (show all 289)
# Title Authors Year
1
Importance of clinical signs leading to the diagnosis in a case of microbiological smear negative ocular microsporidiosis. ( 30709889 )
2019
2
Effects of microsporidiosis and food availability on the two-spotted lady beetle, Adalia bipunctata L., and convergent lady beetle, Hippodamia convergens Guérin-Méneville. ( 30580010 )
2019
3
A new scope for orlistat: Effect of approved anti-obesity drug against experimental microsporidiosis. ( 29529254 )
2019
4
Therapeutic targets for the treatment of microsporidiosis in humans. ( 30336698 )
2018
5
Respiratory microsporidiosis caused by Enterocytozoon bieneusi in an HIV-negative hematopoietic stem cell transplant recipient. ( 30063985 )
2018
6
Intestinal microsporidiosis in Strasbourg from 2014 to 2016: emergence of an Enterocytozoon bieneusi genotype of Asian origin. ( 29872051 )
2018
7
Case Report: Ocular Microsporidiosis: Case in a Patient Returning from India and Review of the Literature. ( 29692301 )
2018
8
Renal Microsporidiosis in Pediatric Bone Marrow Transplant Recipients: A Case Series. ( 29630083 )
2018
9
Outbreak of enteric microsporidiosis of hatchery-bred juvenile groupers, Epinephelus spp., associated with a new intranuclear microporidian in China. ( 27593948 )
2017
10
Laboratory cohabitation challenge model for shrimp hepatopancreatic microsporidiosis (HPM) caused by Enterocytozoon hepatopenaei (EHP). ( 28056950 )
2017
11
Microsporidiosis in Four Tortoises ( Testudo hermanni boettgeri). ( 28171733 )
2017
12
Intestinal microsporidiosis in Iran: infection in immune-compromised and immunocompetent patients. ( 29302628 )
2017
13
MICROSPORIDIOSIS IN PEPPERMINT SHRIMP (DECAPODA: HIPPOLYTIDAE: LYSMATA SPP.). ( 29297835 )
2017
14
First report of fatal disseminated microsporidiosis in two inland bearded dragons Pogona vitticeps in Japan. ( 29026616 )
2017
15
Microsporidiosis in Iran: A systematic review and meta-analysis. ( 28552104 )
2017
16
Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin ( 28518017 )
2017
17
The first study on opportunistic intestinal microsporidiosis in IBD patients receiving immunosuppressive medications in Iran. ( 28502260 )
2017
18
Three Cases of Neurologic Syndrome Caused by Donor-Derived Microsporidiosis. ( 28220747 )
2017
19
Evaluation of pulmonary microsporidiosis in iatrogenically immunosuppressed patients. ( 27266280 )
2016
20
PREVALENCE AND RISK FACTORS FOR ASYMPTOMATIC INTESTINAL MICROSPORIDIOSIS AMONG ABORIGINAL SCHOOL CHILDREN IN PAHANG, MALAYSIA. ( 27405127 )
2016
21
Comparative evaluation of staining techniques and polymerase chain reaction for diagnosis of intestinal microsporidiosis in immunocompromised patients. ( 26629452 )
2015
22
Molecular detection of microsporidiosis in various samples of Iranian immunocompromised patients. ( 26688625 )
2015
23
Microsporidiosis in Vertebrate Companion Exotic Animals. ( 29376921 )
2015
24
Intestinal microsporidiosis. ( 26004651 )
2015
25
Intestinal microsporidiosis in renal transplant recipients: Prevalence, predictors of occurrence and genetic characterization. ( 26068335 )
2015
26
A study of microsporidiosis in corneal scrapings of keratitis patients referring to Farabi Eye Hospital, Tehran, Iran in 2013-14. ( 28680995 )
2015
27
Microsporidiosis: an unusual endoscopic finding. ( 23978344 )
2014
28
Microsporidiosis acquired through solid organ transplantation: a public health investigation. ( 24727839 )
2014
29
Extraintestinal microsporidiosis. ( 24829239 )
2014
30
Cerebral microsporidiosis manifesting as progressive multifocal leukoencephalopathy in an HIV-infected individual - a case report. ( 25057277 )
2014
31
Microsporidiosis in pediatric renal transplant patients in Cape Town, South Africa: two case reports. ( 25132634 )
2014
32
Hepatic steatosis associated with microsporidiosis in teleost fishes from Marajó Island, Brazil. ( 25211110 )
2014
33
Hepatic steatosis associated with microsporidiosis in teleost fishes from Marajó Island, Brazil. ( 25229262 )
2014
34
Genital microsporidiosis in women with AIDS: a post-mortem study. ( 22554823 )
2013
35
Intestinal microsporidiosis in India: a two year study. ( 23022364 )
2013
36
Latent microsporidiosis caused by Encephalitozoon cuniculi in immunocompetent hosts: a murine model demonstrating the ineffectiveness of the immune system and treatment with albendazole. ( 23593356 )
2013
37
Disseminated microsporidiosis in a renal transplant recipient: case report and review of the literature. ( 23947513 )
2013
38
Comparison of staining techniques and multiplex nested PCR for diagnosis of intestinal microsporidiosis. ( 23993212 )
2013
39
Intestinal microsporidiosis in a reference center. ( 24120827 )
2013
40
Intestinal microsporidiosis due to Enterocytozoon bieneusi in a pediatric kidney transplant recipient successfully treated with fumagillin. ( 24132119 )
2013
41
Successful treatment with fumagillin of the first pediatric case of digestive microsporidiosis in a liver-kidney transplant. ( 24298986 )
2013
42
Epidemiology, clinical, immune, and molecular profiles of microsporidiosis and cryptosporidiosis among HIV/AIDS patients. ( 22924007 )
2012
43
Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis. ( 23025483 )
2012
44
Changing prevalence of human microsporidiosis. ( 22261187 )
2012
45
Disseminated microsporidiosis with Encephalitozoon species in a renal transplant recipient. ( 22497646 )
2012
46
Disseminated microsporidiosis in an immunosuppressed patient. ( 22709509 )
2012
47
Microsporidiosis in zebrafish research facilities. ( 23382342 )
2012
48
Microsporidiosis and Cryptosporidiosis in HIV/AIDS Patients in St. Petersburg, Russia: Serological identification of microsporidia and Cryptosporidium parvum in sera samples from HIV/AIDS patients. ( 20929396 )
2011
49
Microsporidiosis: Enterocytozoon bieneusi in domesticated and wild animals. ( 20699192 )
2011
50
Evaluation of the co-agglutination test in diagnosis of experimental microsporidiosis. ( 21296078 )
2011
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Variations for Microsporidiosis

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Expression for Microsporidiosis

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Search GEO for disease gene expression data for Microsporidiosis.
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Pathways for Microsporidiosis

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Pathways related to Microsporidiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Doxorubicin Pathway, Pharmacokinetics 62
Show member pathways
 11.01 ABCB1 ABCC1
2
Gemtuzumab ozogamicin Pathway, Pharmacokinetics/Pharmacodynamics 62
10.73 ABCB1 ABCC1
3
Methotrexate Pathway, Pharmacokinetics 62
Show member pathways
 10.62 ABCB1 ABCC1
4
Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics 62
10.51 ABCB1 ABCC1
5
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 62
10.33 ABCB1 ABCC1
6
Taxane Pathway, Pharmacokinetics 62
10.07 ABCB1 ABCC1
7
Vinka Alkaloid Pathway, Pharmacokinetics 62
9.62 ABCB1 ABCC1
Sources

GO Terms for Microsporidiosis

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Cellular components related to Microsporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.62 DEFA1 DEFB4A

Biological processes related to Microsporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.5 ABCB1 ABCC1 RPN2
2 defense response to Gram-positive bacterium GO:0050830 9.48 DEFA1 DEFB4A
3 cell chemotaxis GO:0060326 9.46 ABCC1 DEFB4A
4 defense response to Gram-negative bacterium GO:0050829 9.43 DEFA1 DEFB4A
5 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.4 DEFA1 DEFB4A
6 antimicrobial humoral response GO:0019730 9.37 DEFA1 DEFB4A
7 killing of cells of other organism GO:0031640 9.26 DEFA1 DEFB4A
8 phospholipid translocation GO:0045332 9.16 ABCB1 ABCC1
9 drug transmembrane transport GO:0006855 8.65 ABCC1
10 xenobiotic transport GO:0042908 8.32 ABCC1

Molecular functions related to Microsporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transporter activity GO:0005215 9.16 ABCB1 ABCC1
2 ATPase activity, coupled to transmembrane movement of substances GO:0042626 8.96 ABCB1 ABCC1
3 xenobiotic transmembrane transporting ATPase activity GO:0008559 8.32 ABCC1
Sources

Sources for Microsporidiosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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