MCID: MCR129
MIFTS: 61

Microvascular Complications of Diabetes 1

Categories: Genetic diseases, Eye diseases, Neuronal diseases, Nephrological diseases

Aliases & Classifications for Microvascular Complications of Diabetes 1

MalaCards integrated aliases for Microvascular Complications of Diabetes 1:

Name: Microvascular Complications of Diabetes 1 57 75 29 13 6 40
Proliferative Diabetic Retinopathy 12 75 55 15 73
Diabetic Nephropathy 75 73
Mvcd1 57 75
Microvascular Complications of Diabetes, Susceptibility to, 1 57
Nonproliferative Retinopathy, Diabetic, Susceptibility to 57
Proliferative Retinopathy, Diabetic, Susceptibility to 57
Nonproliferative Retinopathy, Diabetic 57
Non-Proliferative Diabetic Retinopathy 75
Nonproliferative Diabetic Retinopathy 73
Proliferative Retinopathy, Diabetic 57
Complications of Diabetes Mellitus 73
Diabetic End-Stage Renal Disease 75
Diabetes Complications 44
Diabetic Neuropathies 73
Diabetic Neuropathy 75
Pdr 12

Classifications:



Summaries for Microvascular Complications of Diabetes 1

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 1: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 1, also known as proliferative diabetic retinopathy, is related to meningitis and microvascular complications of diabetes 5, and has symptoms including neuralgia and sciatica. An important gene associated with Microvascular Complications of Diabetes 1 is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include endothelial, eye and monocytes, and related phenotypes are cardiovascular system and cellular

Description from OMIM: 603933

Related Diseases for Microvascular Complications of Diabetes 1

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 meningitis 29.7 CCL2 CXCL8 MMP9
2 microvascular complications of diabetes 5 27.4 ANGPT2 FGF2 FLT1 ICAM1 IGF1 SERPINF1
3 malaria 26.5 ANGPT2 CCL2 CXCL8 ICAM1 MMP9 TGFB2
4 diabetic neuropathy 12.5
5 microvascular complications of diabetes 3 12.2
6 background diabetic retinopathy 11.5
7 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.5
8 microvascular complications of diabetes 7 11.5
9 severe nonproliferative diabetic retinopathy 11.3
10 acidophil adenoma 10.9 IGF1 SST
11 pituitary infarct 10.8 IGF1 SST
12 wrinkles 10.8 HGF VEGFA
13 critical limb ischemia 10.8 HGF VEGFA
14 pyogenic granuloma 10.7 ANGPT2 VEGFA
15 diabetic angiopathy 10.7
16 hormone producing pituitary cancer 10.7 IGF1 SST
17 carcinoid syndrome 10.6 IGF1 SST VEGFA
18 pituitary adenoma 1, multiple types 10.6 IGF1 SST
19 pituitary tumors 10.6 IGF1 SST VEGFA
20 angiodysplasia 10.6 FGF2 SST VEGFA
21 chronic myocardial ischemia 10.6 FGF2 HGF VEGFA
22 retinal vein occlusion 10.6 CCL2 SERPINF1 VEGFA
23 hemangioma 10.5 ANGPT2 FGF2 VEGFA
24 short bowel syndrome 10.5 HGF IGF1 SST
25 male reproductive organ cancer 10.5 IGF1 MMP9 VEGFA
26 vibratory urticaria 10.4 CXCL8 MMP9
27 peripheral artery disease 10.4 CCL2 VCAM1 VEGFA
28 israeli tick typhus 10.4 CCL2 CXCL8
29 keratitis, hereditary 10.4 FGF2 MMP9 VEGFA
30 acute transverse myelitis 10.4 CXCL8 MMP9
31 acquired metabolic disease 10.4 CCL2 IGF1 SST
32 severe pre-eclampsia 10.4 MMP9 VCAM1 VEGFA
33 clivus chordoma 10.4 CXCL12 FGF2
34 lymphocytic vasculitis 10.4 ICAM1 VCAM1
35 glomeruloid hemangioma 10.4 FLT1 VEGFA
36 toxicodendron dermatitis 10.3 CXCL8 ICAM1
37 gastric ulcer 10.3 CXCL8 FGF2 HGF
38 autosomal dominant polycystic kidney disease 10.3 CCL2 IGF1 VEGFA
39 endometriosis 10.3 CCL2 CXCL8 VEGFA
40 sapho syndrome 10.3 CXCL8 VEGFA
41 leukostasis 10.3 ICAM1 VCAM1 VEGFA
42 denture stomatitis 10.3 CCL2 CXCL8
43 mooren's ulcer 10.2 ICAM1 VCAM1
44 lipodermatosclerosis 10.2 ANGPT2 FLT1 VEGFA
45 sick building syndrome 10.2 MMP9 VEGFA
46 viral encephalitis 10.2 CCL2 CXCL8 VCAM1
47 scleritis 10.2 CCL2 MMP9
48 cortical thymoma 10.2 ICAM1 SST VCAM1
49 placental insufficiency 10.2 ANGPT2 FLT1 VEGFA
50 arteriosclerosis obliterans 10.2 HGF ICAM1 VCAM1

Comorbidity relations with Microvascular Complications of Diabetes 1 via Phenotypic Disease Network (PDN): (show all 24)


Acute Cystitis Acute Kidney Failure
Benign Essential Hypertension Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Cataract
Diabetic Polyneuropathy Heart Disease
Hypertension, Essential Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 7 Mitral Valve Disease
Neurogenic Arthropathy Peripheral Vascular Disease
Rubeosis Iridis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 1:



Diseases related to Microvascular Complications of Diabetes 1

Symptoms & Phenotypes for Microvascular Complications of Diabetes 1

Clinical features from OMIM:

603933

UMLS symptoms related to Microvascular Complications of Diabetes 1:


neuralgia, sciatica

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 1:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.34 TGFB2 MMP9 SERPINF1 IGF1 VEGFA VCAM1
2 cellular MP:0005384 10.29 TGFB2 MMP9 IGF1 VEGFA VCAM1 ANGPT2
3 hematopoietic system MP:0005397 10.2 IGF1 TGFB2 MMP9 SERPINF1 VEGFA VCAM1
4 growth/size/body region MP:0005378 10.18 SST IGF1 MMP9 ICAM1 VCAM1 VEGFA
5 immune system MP:0005387 10.18 SST TGFB2 MMP9 SERPINF1 IGF1 VEGFA
6 mortality/aging MP:0010768 10.18 IGF1 SST TGFB2 MMP9 VEGFA VCAM1
7 homeostasis/metabolism MP:0005376 10.17 SST IGF1 TGFB2 MMP9 ICAM1 VEGFA
8 digestive/alimentary MP:0005381 10.1 SST TGFB2 MMP9 ICAM1 SERPINF1 VEGFA
9 nervous system MP:0003631 9.96 SST IGF1 TGFB2 MMP9 ICAM1 SERPINF1
10 muscle MP:0005369 9.92 IGF1 TGFB2 MMP9 ICAM1 VEGFA FLT1
11 reproductive system MP:0005389 9.81 IGF1 TGFB2 MMP9 SERPINF1 VEGFA VCAM1
12 skeleton MP:0005390 9.56 SERPINF1 SST IGF1 TGFB2 MMP9 VEGFA
13 vision/eye MP:0005391 9.28 TGFB2 MMP9 SERPINF1 VEGFA ANGPT2 FLT1

Drugs & Therapeutics for Microvascular Complications of Diabetes 1

Genetic Tests for Microvascular Complications of Diabetes 1

Genetic tests related to Microvascular Complications of Diabetes 1:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 1 29 VEGFA

Anatomical Context for Microvascular Complications of Diabetes 1

MalaCards organs/tissues related to Microvascular Complications of Diabetes 1:

41
Endothelial, Eye, Monocytes, Placenta, Retina, Tongue, Myeloid

Publications for Microvascular Complications of Diabetes 1

Articles related to Microvascular Complications of Diabetes 1:

(show top 50) (show all 627)
# Title Authors Year
1
Evaluation of TGF-Beta 2 and VEGF<i>I+</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes. ( 29850215 )
2018
2
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. ( 29351334 )
2018
3
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
4
Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy. ( 29643784 )
2018
5
NONHEREDITARY IDIOPATHIC FOVEAL RETINOSCHISIS ASSOCIATED WITH NEW-ONSET PROLIFERATIVE DIABETIC RETINOPATHY. ( 29176525 )
2017
6
Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy. ( 28272234 )
2017
7
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy. ( 27860331 )
2017
8
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study. ( 28446148 )
2017
9
A case of pseudoxanthoma elasticum with proliferative diabetic retinopathy. ( 28978321 )
2017
10
Serous retinal detachment after panretinal photocoagulation for proliferative diabetic retinopathy: a case report. ( 28923115 )
2017
11
Association of IL-6 Gene (-174 and -572 G/C) Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Population. ( 28651253 )
2017
12
MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. ( 28571008 )
2017
13
The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. ( 28973045 )
2017
14
Association of functional SNP-1562C&amp;gt;T in MMP9 promoter with proliferative diabetic retinopathy in north Indian type 2 diabetes mellitus patients. ( 28964682 )
2017
15
Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes. ( 26940815 )
2016
16
Association of Complement C5 Gene Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Han Population. ( 26934706 )
2016
17
Preoperative intravitreal injection of ranibizumab for patients with severe proliferative diabetic retinopathy contributes to a decreased risk of postoperative neovascular glaucoma. ( 27010230 )
2016
18
Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells. ( 27050952 )
2016
19
Association between FNDC5 genetic variants and proliferative diabetic retinopathy in a Chinese population. ( 26926664 )
2016
20
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. ( 26039997 )
2015
21
Painless Indirect Argon Laser in High Risk Proliferative Diabetic Retinopathy. ( 25902110 )
2015
22
Progression to macula-off tractional retinal detachment after a contralateral intraoperative intravitreal bevacizumab injection for proliferative diabetic retinopathy. ( 25784784 )
2015
23
High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with proliferative diabetic retinopathy. ( 25822410 )
2015
24
Role of NF-I_B activation and VEGF gene polymorphisms in VEGF up regulation in non-proliferative and proliferative diabetic retinopathy. ( 25956512 )
2015
25
Multimodal Characterization of Proliferative Diabetic Retinopathy Reveals Alterations in Outer Retinal Function and Structure. ( 25601533 )
2015
26
Increase of Sialylated N-Glycansin Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy. ( 26177396 )
2015
27
The -308G&amp;gt;a polymorphism of the TNF gene is associated with proliferative diabetic retinopathy in Caucasian Brazilians with type 2 diabetes. ( 25634985 )
2015
28
Expression of intraocular peroxisome proliferator-activated receptor gamma in patients with proliferative diabetic retinopathy. ( 25468312 )
2015
29
Progression to macula-off tractional retinal detachment after a contralateral intraoperative intravitreal bevacizumab injection for proliferative diabetic retinopathy. ( 25609907 )
2015
30
Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy. ( 27215012 )
2015
31
The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy. ( 25676319 )
2015
32
The angiogenic biomarker endocan is upregulated in proliferative diabetic retinopathy and correlates with vascular endothelial growth factor. ( 24871583 )
2015
33
Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular oedema. ( 25631486 )
2015
34
Genetic algorithm based feature selection combined with dual classification for the automated detection of proliferative diabetic retinopathy. ( 25841182 )
2015
35
Re: Role of combined cataract surgery and ranibizumab injection in postoperative macula edema in non-proliferative diabetic retinopathy. ( 25635581 )
2015
36
Programmed Death 1 (PD-1) is involved in the development of proliferative diabetic retinopathy by mediating activation-induced apoptosis. ( 26321864 )
2015
37
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes. ( 26720478 )
2015
38
Social deprivation as a risk factor for late presentation of proliferative diabetic retinopathy. ( 25733801 )
2015
39
The effects of pleiotrophin in proliferative diabetic retinopathy. ( 25617851 )
2015
40
The rs3917779 polymorphism of P-selectin's significant association with proliferative diabetic retinopathy in Yazd, Iran. ( 26344728 )
2015
41
Pan-retinal photocoagulation and other forms of laser treatment and drug therapies for non-proliferative diabetic retinopathy: systematic review and economic evaluation. ( 26173799 )
2015
42
Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy. ( 25899460 )
2015
43
Elevated LRP6 levels correlate with vascular endothelial growth factor in the vitreous of proliferative diabetic retinopathy. ( 26120271 )
2015
44
Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy. ( 25686060 )
2015
45
CHRONIC MYELOID LEUKEMIA DIAGNOSED IN A PATIENT WITH UNCONTROLLED PROLIFERATIVE DIABETIC RETINOPATHY. ( 25719936 )
2015
46
Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy. ( 25604687 )
2015
47
Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). ( 25637870 )
2015
48
Surgical management of retinal diseases: proliferative diabetic retinopathy and traction retinal detachment. ( 25196770 )
2014
49
Effect of sulodexide in patients with non-proliferative diabetic retinopathy: diabetic retinopathy sulodexide study (DRESS). ( 25112845 )
2014
50
Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy. ( 25329921 )
2014

Variations for Microvascular Complications of Diabetes 1

ClinVar genetic disease variations for Microvascular Complications of Diabetes 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 VEGFA NM_001025366.2(VEGFA): c.-94C> G single nucleotide variant risk factor rs2010963 GRCh37 Chromosome 6, 43738350: 43738350
2 VEGFA NM_001025366.2(VEGFA): c.-94C> G single nucleotide variant risk factor rs2010963 GRCh38 Chromosome 6, 43770613: 43770613

Expression for Microvascular Complications of Diabetes 1

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 1.

Pathways for Microvascular Complications of Diabetes 1

Pathways related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CTGF CXCL12 FGF2 FLT1 HGF IGF1
2
Show member pathways
13.84 ANGPT2 CCL2 CTGF CXCL12 CXCL8 FGF2
3
Show member pathways
13.72 CTGF CXCL12 FGF2 FLT1 HGF IGF1
4
Show member pathways
13.66 ANGPT2 CCL2 CXCL12 CXCL8 FLT1 HGF
5
Show member pathways
13.53 CTGF CXCL12 FGF2 FLT1 HGF IGF1
6
Show member pathways
13.41 CCL2 CXCL12 CXCL8 ICAM1 MMP9 TGFB2
7
Show member pathways
13.41 ANGPT2 CCL2 CTGF CXCL12 CXCL8 FGF2
8
Show member pathways
13.4 ANGPT2 CCL2 CTGF CXCL12 CXCL8 FGF2
9
Show member pathways
13.36 CCL2 CXCL8 FGF2 HGF ICAM1 MMP9
10
Show member pathways
13.33 CTGF CXCL12 FGF2 FLT1 HGF IGF1
11
Show member pathways
13.27 CTGF CXCL12 FGF2 FLT1 HGF IGF1
12
Show member pathways
13.24 ANGPT2 CCL2 CTGF CXCL12 CXCL8 FGF2
13
Show member pathways
13.07 CTGF CXCL12 FGF2 FLT1 HGF IGF1
14
Show member pathways
12.99 ANGPT2 FGF2 FLT1 HGF IGF1 VEGFA
15
Show member pathways
12.99 CCL2 CTGF CXCL12 FGF2 FLT1 HGF
16 12.82 CXCL12 CXCL8 FGF2 HGF IGF1 MMP9
17 12.8 ANGPT2 FGF2 FLT1 HGF IGF1 TGFB2
18
Show member pathways
12.78 FGF2 HGF IGF1 MMP9 VEGFA
19
Show member pathways
12.76 FGF2 ICAM1 MMP9 TGFB2 VCAM1
20
Show member pathways
12.75 ANGPT2 FGF2 FLT1 HGF IGF1 VEGFA
21
Show member pathways
12.74 CTGF CXCL12 FGF2 FLT1 HGF IGF1
22
Show member pathways
12.67 CCL2 CXCL12 ICAM1 MMP9 VCAM1 VEGFA
23
Show member pathways
12.6 ANGPT2 CXCL8 FGF2 ICAM1 MMP9 TGFB2
24
Show member pathways
12.4 CCL2 ICAM1 VCAM1 VEGFA
25 12.35 FGF2 HGF IGF1 MMP9 TGFB2 VEGFA
26 12.27 CXCL8 FLT1 IGF1 MMP9
27 12.14 CCL2 ICAM1 MMP9 VCAM1 VEGFA
28 12.11 FGF2 HGF IGF1 VCAM1 VEGFA
29 12.06 CTGF ICAM1 MMP9 VCAM1
30 12.05 CCL2 CXCL8 ICAM1 MMP9
31 11.99 CCL2 ICAM1 MMP9 VCAM1
32
Show member pathways
11.97 CCL2 CXCL12 CXCL8
33 11.95 ANGPT2 FLT1 IGF1 VEGFA
34 11.92 CXCL12 CXCL8 ICAM1 VCAM1
35 11.88 CCL2 CXCL8 ICAM1 TGFB2 VCAM1 VEGFA
36 11.82 CCL2 CXCL12 CXCL8 FLT1 ICAM1 TGFB2
37
Show member pathways
11.81 CXCL12 CXCL8 VCAM1
38 11.79 FGF2 IGF1 VEGFA
39 11.75 CXCL8 MMP9 VEGFA
40 11.75 ANGPT2 CCL2 FGF2 FLT1 HGF MMP9
41 11.73 FGF2 IGF1 MMP9 TGFB2 VEGFA
42
Show member pathways
11.71 CXCL8 ICAM1 MMP9 VCAM1 VEGFA
43 11.67 CXCL8 IGF1 MMP9
44 11.61 CCL2 CXCL8 FGF2 HGF ICAM1 MMP9
45 11.59 FGF2 HGF IGF1 VEGFA
46 11.56 FGF2 TGFB2 VEGFA
47 11.56 CCL2 CXCL8 ICAM1
48 11.55 CTGF ICAM1 MMP9
49 11.54 CCL2 CXCL8 HGF ICAM1 TGFB2 VCAM1
50 11.51 CXCL8 ICAM1 VCAM1

GO Terms for Microvascular Complications of Diabetes 1

Cellular components related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ANGPT2 CCL2 CTGF CXCL12 CXCL8 FGF2
2 extracellular matrix GO:0031012 9.56 ICAM1 MMP9 SERPINF1 TGFB2
3 extracellular space GO:0005615 9.53 ANGPT2 CCL2 CTGF CXCL12 CXCL8 FGF2
4 platelet alpha granule lumen GO:0031093 9.46 HGF IGF1 TGFB2 VEGFA

Biological processes related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.95 CTGF SERPINF1 TGFB2 VEGFA
2 extracellular matrix organization GO:0030198 9.93 FGF2 ICAM1 MMP9 VCAM1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 CCL2 CTGF FGF2 FLT1 ICAM1
4 positive regulation of cell proliferation GO:0008284 9.92 CTGF CXCL12 FGF2 FLT1 HGF IGF1
5 positive regulation of protein phosphorylation GO:0001934 9.9 CTGF HGF MMP9 VEGFA
6 response to organic cyclic compound GO:0014070 9.88 ANGPT2 CTGF ICAM1
7 positive regulation of cell migration GO:0030335 9.88 CXCL12 FLT1 HGF IGF1 MMP9 VEGFA
8 activation of MAPK activity GO:0000187 9.87 FGF2 HGF IGF1
9 negative regulation of angiogenesis GO:0016525 9.87 ANGPT2 SERPINF1 TGFB2
10 cellular response to tumor necrosis factor GO:0071356 9.87 CCL2 CXCL8 ICAM1 VCAM1
11 kidney development GO:0001822 9.86 SERPINF1 TGFB2 VEGFA
12 platelet degranulation GO:0002576 9.86 HGF IGF1 TGFB2 VEGFA
13 chemotaxis GO:0006935 9.85 CCL2 CXCL12 CXCL8 FGF2 FLT1
14 response to hypoxia GO:0001666 9.85 ANGPT2 CXCL12 ICAM1 TGFB2 VCAM1 VEGFA
15 cellular response to interleukin-1 GO:0071347 9.84 CCL2 CXCL8 ICAM1
16 response to glucose GO:0009749 9.84 ANGPT2 CTGF IGF1
17 chemokine-mediated signaling pathway GO:0070098 9.83 CCL2 CXCL12 CXCL8
18 positive regulation of endothelial cell proliferation GO:0001938 9.83 CXCL12 FGF2 VEGFA
19 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 HGF ICAM1 IGF1 VEGFA
20 neutrophil chemotaxis GO:0030593 9.82 CCL2 CXCL8 TGFB2
21 positive regulation of MAP kinase activity GO:0043406 9.81 FGF2 FLT1 VEGFA
22 cell chemotaxis GO:0060326 9.81 CCL2 CXCL12 HGF VCAM1
23 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 FLT1 HGF IGF1 TGFB2
24 response to heat GO:0009408 9.79 CXCL12 IGF1 SST
25 positive regulation of cell division GO:0051781 9.79 FGF2 TGFB2 VEGFA
26 animal organ regeneration GO:0031100 9.78 ANGPT2 CXCL12 HGF
27 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 FGF2 IGF1 MMP9
28 cytokine-mediated signaling pathway GO:0019221 9.76 CCL2 CXCL8 FGF2 HGF ICAM1 MMP9
29 response to amino acid GO:0043200 9.75 CTGF ICAM1 SST
30 positive chemotaxis GO:0050918 9.73 CXCL12 FGF2 HGF VEGFA
31 positive regulation of angiogenesis GO:0045766 9.73 ANGPT2 CXCL8 FGF2 FLT1 HGF VEGFA
32 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.72 FLT1 VCAM1 VEGFA
33 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.71 FLT1 VEGFA
34 macrophage differentiation GO:0030225 9.7 MMP9 VEGFA
35 embryonic digestive tract development GO:0048566 9.7 CXCL8 TGFB2
36 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.7 HGF IGF1
37 embryonic morphogenesis GO:0048598 9.69 FGF2 FLT1
38 positive regulation of calcium ion import GO:0090280 9.69 CCL2 CXCL12
39 cell migration involved in sprouting angiogenesis GO:0002042 9.68 FGF2 VEGFA
40 response to acidic pH GO:0010447 9.68 SERPINF1 SST
41 PERK-mediated unfolded protein response GO:0036499 9.67 CCL2 CXCL8
42 positive regulation of phospholipase C activity GO:0010863 9.66 FGF2 FLT1
43 induction of positive chemotaxis GO:0050930 9.65 CXCL12 CXCL8 VEGFA
44 positive regulation of axon extension involved in axon guidance GO:0048842 9.64 CXCL12 VEGFA
45 membrane to membrane docking GO:0022614 9.62 ICAM1 VCAM1
46 myoblast proliferation GO:0051450 9.59 HGF IGF1
47 angiogenesis GO:0001525 9.56 ANGPT2 CCL2 CTGF CXCL8 FGF2 FLT1
48 regulation of signaling receptor activity GO:0010469 9.32 CCL2 CTGF CXCL12 CXCL8 FGF2 HGF
49 cell adhesion GO:0007155 10.08 CCL2 CTGF CXCL12 ICAM1 VCAM1
50 negative regulation of apoptotic process GO:0043066 10.07 FLT1 HGF IGF1 MMP9 VEGFA

Molecular functions related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.63 CCL2 CXCL12 CXCL8 FGF2 TGFB2 VEGFA
2 chemoattractant activity GO:0042056 9.56 CXCL12 FGF2 HGF VEGFA
3 chemokine activity GO:0008009 9.5 CCL2 CXCL12 CXCL8
4 integrin binding GO:0005178 9.43 CTGF CXCL12 FGF2 ICAM1 IGF1 VCAM1
5 CXCR chemokine receptor binding GO:0045236 9.37 CXCL12 CXCL8
6 growth factor activity GO:0008083 9.17 CTGF CXCL12 FGF2 HGF IGF1 TGFB2

Sources for Microvascular Complications of Diabetes 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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