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MVCD1
MCID: MCR129
MIFTS: 64

Microvascular Complications of Diabetes 1 (MVCD1)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Nephrological diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Microvascular Complications of Diabetes 1

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MalaCards integrated aliases for Microvascular Complications of Diabetes 1:

Name: Microvascular Complications of Diabetes 1 57 75 29 13 6 40
Proliferative Diabetic Retinopathy 12 75 55 15 73
Diabetic Nephropathy 75 73
Mvcd1 57 75
Microvascular Complications of Diabetes, Susceptibility to, 1 57
Nonproliferative Retinopathy, Diabetic, Susceptibility to 57
Proliferative Retinopathy, Diabetic, Susceptibility to 57
Nonproliferative Retinopathy, Diabetic 57
Non-Proliferative Diabetic Retinopathy 75
Nonproliferative Diabetic Retinopathy 73
Proliferative Retinopathy, Diabetic 57
Complications of Diabetes Mellitus 73
Diabetic End-Stage Renal Disease 75
Diabetes Complications 44
Diabetic Neuropathies 73
Diabetic Neuropathy 75
Pdr 12

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Cardiovascular diseases Eye diseases Neuronal diseases Nephrological diseases
See all MalaCards categories (disease lists)


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Summaries for Microvascular Complications of Diabetes 1

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UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 1: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 1, also known as proliferative diabetic retinopathy, is related to background diabetic retinopathy and vitreoretinopathy, neovascular inflammatory, and has symptoms including sciatica and neuralgia. An important gene associated with Microvascular Complications of Diabetes 1 is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include eye, endothelial and kidney, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 76 The complications of diabetes mellitus are far less common and less severe in people who have... more...

Description from OMIM: 603933
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Related Diseases for Microvascular Complications of Diabetes 1

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Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 380)
# Related Disease Score Top Affiliating Genes
1 background diabetic retinopathy 33.3 ANGPT2 INS VEGFA
2 vitreoretinopathy, neovascular inflammatory 33.0 CCL2 FGF2 HGF
3 severe nonproliferative diabetic retinopathy 32.5 INS VEGFA
4 diabetes mellitus, noninsulin-dependent 31.1 AKR1B1 CCL2 IGF1 INS SST VCAM1
5 macular holes 30.7 ANGPT2 CCL2 CXCL8 SERPINF1 VEGFA
6 hyperglycemia 30.7 AKR1B1 IGF1 INS SST
7 rubeosis iridis 30.7 IGF1 INS VEGFA
8 diabetic macular edema 30.6 CCL2 FGF2 ICAM1 SERPINF1 SST VEGFA
9 diabetic polyneuropathy 30.5 AKR1B1 NTF3 VEGFA
10 acromegaly 30.4 IGF1 INS SST
11 diabetes mellitus, insulin-dependent 30.3 AKR1B1 IGF1 INS SST
12 chronic kidney failure 30.2 ICAM1 IGF1 INS VCAM1
13 retinal vascular disease 30.2 AKR1B1 CCL2 ICAM1 INS SERPINF1 VEGFA
14 malaria 30.2 ANGPT2 CCL2 CXCL8 ICAM1 MMP9 VCAM1
15 insulin-like growth factor i 30.1 IGF1 INS SST
16 heart disease 30.1 CXCL8 ICAM1 IGF1 INS VEGFA
17 vascular disease 30.1 CCL2 FGF2 INS MIR21 MMP9 VCAM1
18 macular retinal edema 30.1 CCL2 ICAM1 VEGFA
19 arteries, anomalies of 30.1 CCL2 ICAM1 INS MMP9 VCAM1 VEGFA
20 meningitis 30.1 CCL2 CXCL8 MMP9
21 sleep apnea 30.0 CXCL8 ICAM1 IGF1 INS
22 diabetic autonomic neuropathy 30.0 AKR1B1 INS NTF3
23 microvascular complications of diabetes 5 29.9 AKR1B1 ANGPT2 FGF2 ICAM1 IGF1 INS
24 diabetic neuropathy 29.9 AKR1B1 INS NTF3 VEGFA
25 arteriosclerosis obliterans 29.9 HGF ICAM1 VCAM1
26 peripheral artery disease 29.9 CCL2 VCAM1 VEGFA
27 diabetic foot ulcers 29.8 CCL2 MMP9
28 arteriosclerosis 29.8 CCL2 HGF ICAM1 INS MMP9 VCAM1
29 myeloma, multiple 29.8 CXCL8 FGF2 HGF IGF1 VEGFA
30 vasculitis 29.7 CCL2 ICAM1 VCAM1
31 myocardial infarction 29.5 CCL2 ICAM1 INS MIR21 MMP9 VEGFA
32 periodontitis 29.5 CCL2 CXCL8 MMP9
33 microvascular complications of diabetes 3 12.4
34 microvascular complications of diabetes 4 12.2
35 microvascular complications of diabetes 6 12.2
36 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.7
37 microvascular complications of diabetes 7 11.6
38 perrault syndrome 1 11.1
39 diabetic angiopathy 11.1
40 kidney disease 11.0
41 abducens nerve disease 10.9
42 argyll robertson pupil 10.9
43 syncope 10.9
44 diabetes mellitus 10.8
45 retinal detachment 10.6
46 renal fibrosis 10.5
47 neovascular glaucoma 10.4
48 acidophil adenoma 10.3 IGF1 SST
49 diabetic cataract 10.3 AKR1B1 SERPINF1 VEGFA
50 secondary adrenal insufficiency 10.3 IGF1 INS

Comorbidity relations with Microvascular Complications of Diabetes 1 via Phenotypic Disease Network (PDN): (show all 24)


Acute Cystitis Acute Kidney Failure
Benign Essential Hypertension Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Diabetic Cataract
Diabetic Polyneuropathy Heart Disease
Hypertension, Essential Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Microvascular Complications of Diabetes 7 Mitral Valve Disease
Neurogenic Arthropathy Peripheral Vascular Disease
Rubeosis Iridis Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 1:



Diseases related to Microvascular Complications of Diabetes 1
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Symptoms & Phenotypes for Microvascular Complications of Diabetes 1

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Clinical features from OMIM:

603933

UMLS symptoms related to Microvascular Complications of Diabetes 1:


sciatica, neuralgia

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ANGPT2 FGF2 HGF ICAM1 IGF1 INS
2 digestive/alimentary MP:0005381 9.5 ANGPT2 ICAM1 INS MMP9 SERPINF1 SST
3 vision/eye MP:0005391 9.28 AKR1B1 ANGPT2 FGF2 ICAM1 INS MMP9
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Drugs & Therapeutics for Microvascular Complications of Diabetes 1

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Search Clinical Trials , NIH Clinical Center for Microvascular Complications of Diabetes 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: diabetes complications

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Genetic Tests for Microvascular Complications of Diabetes 1

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Genetic tests related to Microvascular Complications of Diabetes 1:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 1 29 VEGFA
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Anatomical Context for Microvascular Complications of Diabetes 1

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MalaCards organs/tissues related to Microvascular Complications of Diabetes 1:

41
Eye, Endothelial, Kidney, Lung, Brain, Heart, Retina
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Publications for Microvascular Complications of Diabetes 1

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Articles related to Microvascular Complications of Diabetes 1:

(show top 50) (show all 1018)
# Title Authors Year
1
Evaluation of TGF-Beta 2 and VEGF<i>I+</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes. ( 29850215 )
2018
2
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. ( 29351334 )
2018
3
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
4
The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus. ( 30531682 )
2018
5
Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy. ( 29739359 )
2018
6
Association of Abnormal Renal Profiles and Proliferative Diabetic Retinopathy and Diabetic Macular Edema in an Asian Population With Type 2 Diabetes. ( 29167896 )
2018
7
Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy. ( 29643784 )
2018
8
Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy. ( 30532517 )
2018
9
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment in Eyes with Proliferative Diabetic Retinopathy. ( 30524755 )
2018
10
INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES. ( 30148749 )
2018
11
Role of combined phacoemulsification and intravitreal injection of bevacizumab in prevention of postoperative macular edema in non-proliferative diabetic retinopathy. ( 30197955 )
2018
12
Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study). ( 29395119 )
2018
13
BIMANUAL MICROINCISION VITREOUS SURGERY FOR SEVERE PROLIFERATIVE DIABETIC RETINOPATHY: OUTCOME IN MORE THAN 300 EYES. ( 29406470 )
2018
14
Plasma metabolic profile reveals PGF2α protecting against non-proliferative diabetic retinopathy in patients with type 2 diabetes. ( 29408756 )
2018
15
Region-specific ischemia, neovascularization and macular oedema in treatment-naïve proliferative diabetic retinopathy. ( 29412501 )
2018
16
Observation of neovascularization of the disc associated with proliferative diabetic retinopathy using OCT angiography. ( 29460018 )
2018
17
Observation of optic disc neovascularization using OCT angiography in proliferative diabetic retinopathy after intravitreal conbercept injections. ( 29507304 )
2018
18
The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization. ( 29536540 )
2018
19
Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis. ( 29541006 )
2018
20
Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation. ( 29542045 )
2018
21
Different lasers and techniques for proliferative diabetic retinopathy. ( 29543992 )
2018
22
Cost Evaluation of Laser versus Intravitreal Aflibercept for Proliferative Diabetic Retinopathy. ( 29571831 )
2018
23
Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections. ( 29606377 )
2018
24
Cost Evaluation of Early Vitrectomy versus Panretinal Photocoagulation and Intravitreal Ranibizumab for Proliferative Diabetic Retinopathy. ( 29606379 )
2018
25
The Correlation between Changes in Biochemical Parameters and Central Macular Thickness in Patients with Non-Proliferative Diabetic Retinopathy. ( 29644239 )
2018
26
Rethinking Management Strategies for Proliferative Diabetic Retinopathy. ( 29664976 )
2018
27
Risk factors for requirement of filtration surgery after vitrectomy in patients with proliferative diabetic retinopathy. ( 29713141 )
2018
28
Correction to: Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation. ( 29744753 )
2018
29
Free amino acids hydroxyproline, lysine, and glycine promote differentiation of retinal pericytes to adipocytes: A protective role against proliferative diabetic retinopathy. ( 29752946 )
2018
30
Successful Midterm Management With an Herbal Decoction, Modified-Goshajinkigan (mGJG) for Non-Proliferative Diabetic Retinopathy: A Case Study. ( 29793732 )
2018
31
Subacute Vision Loss in a Young Pregnant Patient With Proliferative Diabetic Retinopathy. ( 29799966 )
2018
32
Characteristics of Neovascularization in Early Stages of Proliferative Diabetic Retinopathy by Optical Coherence Tomography Angiography. ( 29806991 )
2018
33
Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. ( 29850212 )
2018
34
Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy. ( 29853773 )
2018
35
Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy. ( 29940965 )
2018
36
Correlation Between Vitreous Advanced Glycation End Products, and D-dimer with Blood HbA1c Levels in Proliferative Diabetic Retinopathy. ( 29950532 )
2018
37
Soloist performance of vitrectomy probe in proliferative diabetic retinopathy. ( 29972027 )
2018
38
Panretinal Photocoagulation Versus Ranibizumab for Proliferative Diabetic Retinopathy: Factors Associated with Vision and Edema Outcomes. ( 29980333 )
2018
39
Reversal of Retinal Vascular Leakage and Arrest of Progressive Retinal Nonperfusion With Monthly Anti-Vascular Endothelial Growth Factor Therapy for Proliferative Diabetic Retinopathy. ( 30005003 )
2018
40
Leucine-rich G Protein-coupled Receptor-5 Is Significantly Increased in the Aqueous Humor of Human Eye with Proliferative Diabetic Retinopathy. ( 30022875 )
2018
41
Intraoperative OCT-assisted Surgery for Proliferative Diabetic Retinopathy in the DISCOVER Study. ( 30035245 )
2018
42
Five-Year Outcomes of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. ( 30043039 )
2018
43
Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy. ( 30046459 )
2018
44
Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy. ( 30046542 )
2018
45
Peripheral capillary non-perfusion in treatment-naïve proliferative diabetic retinopathy associates with postoperative disease activity 6 months after panretinal photocoagulation. ( 30068515 )
2018
46
Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti-Vascular Endothelial Growth Factor. ( 30077614 )
2018
47
Rationale and Application of the Protocol S Anti-Vascular Endothelial Growth Factor Algorithm for Proliferative Diabetic Retinopathy. ( 30096354 )
2018
48
Nomogram for prediction of non-proliferative diabetic retinopathy in juvenile-onset type 1 diabetes: a cohort study in an Asian population. ( 30111889 )
2018
49
Proliferative diabetic retinopathy imaged by near-infrared reflectance. ( 30115497 )
2018
50
Paracentral Acute Middle Maculopathy following Vitrectomy for Proliferative Diabetic Retinopathy: Incidence, Risk Factors, and Clinical Characteristics. ( 30126649 )
2018
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Variations for Microvascular Complications of Diabetes 1

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ClinVar genetic disease variations for Microvascular Complications of Diabetes 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 VEGFA NM_001025366.2(VEGFA): c.-94C> G single nucleotide variant risk factor rs2010963 GRCh37 Chromosome 6, 43738350: 43738350
2 VEGFA NM_001025366.2(VEGFA): c.-94C> G single nucleotide variant risk factor rs2010963 GRCh38 Chromosome 6, 43770613: 43770613
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Expression for Microvascular Complications of Diabetes 1

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Search GEO for disease gene expression data for Microvascular Complications of Diabetes 1.
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Pathways for Microvascular Complications of Diabetes 1

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Pathways related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 64
Show member pathways
 13.49 ANGPT2 CCL2 CXCL8 FGF2 HGF ICAM1
2
Akt Signaling 64
Show member pathways
 13.39 ANGPT2 CCL2 CXCL8 FGF2 HGF IGF1
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.36 CCL2 CXCL8 FGF2 HGF ICAM1 MMP9
4
PAK Pathway 64
Show member pathways
 13.29 ANGPT2 CCL2 CXCL8 FGF2 HGF IGF1
5
Human cytomegalovirus infection 37
Show member pathways
 13.05 ANGPT2 CCL2 CXCL8 FGF2 ICAM1 MMP9
6
p70S6K Signaling 64
Show member pathways
 13.04 CCL2 FGF2 HGF IGF1 INS NTF3
7
PI3K-Akt signaling pathway 37
Show member pathways
 12.97 ANGPT2 FGF2 HGF IGF1 INS NTF3
8
Pathways in cancer 37
12.84 CXCL8 FGF2 HGF IGF1 MMP9 VEGFA
9
Glioma 37
Show member pathways
 12.75 FGF2 HGF IGF1 MMP9 VEGFA
10
MAPK signaling pathway 37 1
12.72 ANGPT2 FGF2 HGF IGF1 INS NTF3
11
Ras signaling pathway 37
Show member pathways
 12.68 ANGPT2 FGF2 HGF IGF1 INS NTF3
12
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 65
Show member pathways
 12.65 CCL2 ICAM1 MMP9 VCAM1 VEGFA
13
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.38 CCL2 ICAM1 VCAM1 VEGFA
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.26 CXCL8 FGF2 HGF IGF1 NTF3
15
Proteoglycans in cancer 37
12.24 FGF2 HGF IGF1 MIR21 MMP9 VEGFA
16
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.2 CCL2 CXCL8 ICAM1 MMP9 VCAM1
17
Fluid shear stress and atherosclerosis 37
12.06 CCL2 ICAM1 MMP9 VCAM1 VEGFA
18
Spinal Cord Injury 1
12.01 CCL2 CXCL8 ICAM1 MMP9
19
TNF signaling pathway 37
11.97 CCL2 ICAM1 MMP9 VCAM1
20
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.97 FGF2 HGF IGF1 INS VCAM1 VEGFA
21
HIF-1 signaling pathway 37
11.91 ANGPT2 IGF1 INS VEGFA
22
AGE-RAGE signaling pathway in diabetic complications 37
11.87 CCL2 CXCL8 ICAM1 VCAM1 VEGFA
23
NF-kappa B signaling pathway 37
11.85 CXCL8 ICAM1 VCAM1
24
Rheumatoid arthritis 37
11.85 CCL2 CXCL8 ICAM1 VEGFA
25
Angiogenesis (CST) 4
11.78 ANGPT2 CCL2 FGF2 HGF MMP9
26
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.77 FGF2 IGF1 NTF3 VEGFA
27
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.77 ANGPT2 CCL2 CXCL8 FGF2 HGF ICAM1
28
Bladder cancer 37 1
11.73 CXCL8 MMP9 VEGFA
29
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.71 CCL2 IGF1 MMP9
30
Endochondral Ossification 1
11.66 FGF2 IGF1 MMP9 VEGFA
31
Cell adhesion_ECM remodeling 22
11.64 CXCL8 IGF1 MMP9
32
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 CXCL8 ICAM1 MMP9 VCAM1 VEGFA
33
Cardiac Progenitor Differentiation 1
11.57 FGF2 IGF1 INS
34
Interleukin-10 signaling 66
11.53 CCL2 CXCL8 ICAM1
35
Immune response_Role of integrins in NK cells cytotoxicity 22
11.48 CXCL8 ICAM1 VCAM1
36
Signaling events mediated by TCPTP 1
Show member pathways
 11.45 HGF INS VEGFA
37
Malaria 37
11.41 CCL2 CXCL8 HGF ICAM1 VCAM1
38
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.35 CCL2 CXCL8 MMP9
39
Differentiation Pathway 1
11.34 FGF2 HGF IGF1 INS VEGFA
40
Interleukin-4 and 13 signaling 66
11.28 CCL2 CXCL8 FGF2 HGF ICAM1 MMP9
41
Lung fibrosis 1
11.23 CCL2 CXCL8 FGF2 HGF IGF1 MMP9
42
G-protein signaling_RhoB regulation pathway 22
11.2 ANGPT2 CCL2 CXCL8 HGF
43
IL1 and megakaryocytes in obesity 1
11.18 CCL2 ICAM1 MMP9
44
Angiogenesis (WikiPathways) 1
11.15 FGF2 MMP9 VEGFA
45
G-protein signaling_Rap2B regulation pathway 22
10.98 ANGPT2 CCL2 CXCL8 FGF2 HGF IGF1
46
LDL Oxidation in Atherogenesis 64
10.95 CCL2 ICAM1 VCAM1
Sources

GO Terms for Microvascular Complications of Diabetes 1

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Cellular components related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ANGPT2 CCL2 CXCL8 FGF2 HGF IGF1
2 micro-ribonucleoprotein complex GO:0035068 9.65 MIR192 MIR21 MIR216A MIR217 MIR377
3 extracellular space GO:0005615 9.55 AKR1B1 ANGPT2 CCL2 CXCL8 FGF2 HGF
4 platelet alpha granule lumen GO:0031093 9.33 HGF IGF1 VEGFA

Biological processes related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.96 IGF1 MIR21 SERPINF1 VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 CCL2 FGF2 ICAM1 MIR21
3 extracellular matrix organization GO:0030198 9.94 FGF2 ICAM1 MMP9 VCAM1
4 positive regulation of protein phosphorylation GO:0001934 9.92 HGF MIR21 MMP9 VEGFA
5 response to hypoxia GO:0001666 9.91 ANGPT2 ICAM1 VCAM1 VEGFA
6 positive regulation of protein kinase B signaling GO:0051897 9.91 FGF2 HGF INS MIR21
7 cellular response to lipopolysaccharide GO:0071222 9.9 CCL2 CXCL8 ICAM1 MIR21
8 angiogenesis GO:0001525 9.89 ANGPT2 CCL2 CXCL8 FGF2 VEGFA
9 regulation of cell shape GO:0008360 9.88 CCL2 ICAM1 MIR21 VEGFA
10 cell chemotaxis GO:0060326 9.84 CCL2 HGF VCAM1
11 cellular response to tumor necrosis factor GO:0071356 9.84 CCL2 CXCL8 ICAM1 VCAM1
12 cellular response to interleukin-1 GO:0071347 9.83 CCL2 CXCL8 ICAM1
13 activation of MAPK activity GO:0000187 9.83 FGF2 HGF IGF1 NTF3
14 positive regulation of osteoblast differentiation GO:0045669 9.81 HGF IGF1 MIR21
15 negative regulation of angiogenesis GO:0016525 9.81 ANGPT2 MIR21 MIR217 SERPINF1
16 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 HGF ICAM1 IGF1 NTF3 VEGFA
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 FGF2 IGF1 MIR21 MMP9
18 positive chemotaxis GO:0050918 9.73 FGF2 HGF NTF3 VEGFA
19 positive regulation of angiogenesis GO:0045766 9.73 ANGPT2 CXCL8 FGF2 HGF MIR21 VEGFA
20 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.72 HGF IGF1 INS MIR21 NTF3
21 activation of protein kinase B activity GO:0032148 9.71 IGF1 INS MIR21 NTF3
22 positive regulation of cell migration GO:0030335 9.7 HGF IGF1 INS MIR21 MMP9 NTF3
23 positive regulation of DNA biosynthetic process GO:2000573 9.68 FGF2 HGF
24 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.67 INS MIR21
25 positive regulation of phospholipase C activity GO:0010863 9.67 FGF2 NTF3
26 PERK-mediated unfolded protein response GO:0036499 9.66 CCL2 CXCL8
27 response to acidic pH GO:0010447 9.65 SERPINF1 SST
28 induction of positive chemotaxis GO:0050930 9.65 CXCL8 NTF3 VEGFA
29 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.64 IGF1 MIR21
30 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.63 IGF1 MIR21
31 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.62 ICAM1 MIR21
32 membrane to membrane docking GO:0022614 9.59 ICAM1 VCAM1
33 myoblast proliferation GO:0051450 9.58 HGF IGF1
34 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.57 HGF MIR21
35 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 CXCL8 FGF2 HGF ICAM1 MMP9
36 regulation of signaling receptor activity GO:0010469 9.28 CCL2 CXCL8 FGF2 HGF IGF1 INS
37 gene silencing by miRNA GO:0035195 10.07 MIR192 MIR21 MIR216A MIR217 MIR377
38 negative regulation of apoptotic process GO:0043066 10.03 AKR1B1 HGF IGF1 MIR21 MMP9 VEGFA
39 positive regulation of cell proliferation GO:0008284 10.02 FGF2 IGF1 INS MIR21 NTF3 VEGFA

Molecular functions related to Microvascular Complications of Diabetes 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 CCL2 CXCL8 FGF2 VEGFA
2 integrin binding GO:0005178 9.46 FGF2 ICAM1 IGF1 VCAM1
3 growth factor activity GO:0008083 9.35 FGF2 HGF IGF1 NTF3 VEGFA
4 chemoattractant activity GO:0042056 8.92 FGF2 HGF NTF3 VEGFA
Sources

Sources for Microvascular Complications of Diabetes 1

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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