MVCD2
MCID: MCR112
MIFTS: 42

Microvascular Complications of Diabetes 2 (MVCD2)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 2

MalaCards integrated aliases for Microvascular Complications of Diabetes 2:

Name: Microvascular Complications of Diabetes 2 57 75 29 13 6 40
Proliferative Diabetic Retinopathy 75 73
Diabetic Nephropathy 75 73
Mvcd2 57 75
Microvascular Complications of Diabetes, Susceptibility to, 2 57
Proliferative Retinopathy, Diabetic, Susceptibility to 57
End-Stage Renal Disease, Diabetic, Susceptibility to 57
Proliferative Retinopathy, Diabetic 57
End-Stage Renal Disease, Diabetic 57
Diabetic End-Stage Renal Disease 75

Classifications:



External Ids:

OMIM 57 612623
MeSH 44 D048909

Summaries for Microvascular Complications of Diabetes 2

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 2: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 2, also known as proliferative diabetic retinopathy, is related to microvascular complications of diabetes 4 and microvascular complications of diabetes 6. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). Affiliated tissues include endothelial, eye and retina.

Description from OMIM: 612623

Related Diseases for Microvascular Complications of Diabetes 2

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 4 12.2
2 microvascular complications of diabetes 6 12.2
3 microvascular complications of diabetes 5 12.0
4 background diabetic retinopathy 11.9
5 microvascular complications of diabetes 3 11.8
6 vitreoretinopathy, neovascular inflammatory 11.8
7 microvascular complications of diabetes 7 11.6
8 microvascular complications of diabetes 1 11.5
9 severe nonproliferative diabetic retinopathy 11.4
10 diabetic angiopathy 11.1
11 kidney disease 11.0
12 diabetes mellitus 10.8
13 diabetes mellitus, noninsulin-dependent 10.6
14 retinal detachment 10.6
15 macular retinal edema 10.6
16 renal fibrosis 10.5
17 neovascular glaucoma 10.4
18 cataract 10.3
19 diabetic macular edema 10.3
20 macular holes 10.3
21 glomerulonephritis 10.2
22 hyperglycemia 10.2
23 polyarteritis nodosa, childhood-onset 10.2
24 neuropathy 10.2
25 rubeosis iridis 10.1
26 eales disease 10.1
27 retinitis pigmentosa 10.0
28 homocysteinemia 10.0
29 leber congenital amaurosis 4 10.0
30 leukemia 10.0
31 acromegaly 10.0
32 retinal vascular disease 10.0
33 retinal disease 10.0
34 degos 'en cocarde' erythrokeratoderma 10.0
35 hypertension, essential 10.0
36 vascular disease 10.0
37 hyperuricemia 10.0
38 hypoxia 10.0
39 arteries, anomalies of 10.0
40 diabetes mellitus, insulin-dependent 10.0
41 chronic kidney failure 10.0
42 coronary artery anomaly 10.0
43 heart disease 10.0
44 iga glomerulonephritis 10.0
45 purpura 10.0
46 uremia 10.0
47 end stage renal failure 10.0
48 epidural abscess 10.0
49 muscular atrophy 10.0
50 aging 9.9

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 2:



Diseases related to Microvascular Complications of Diabetes 2

Symptoms & Phenotypes for Microvascular Complications of Diabetes 2

Clinical features from OMIM:

612623

Drugs & Therapeutics for Microvascular Complications of Diabetes 2

Genetic Tests for Microvascular Complications of Diabetes 2

Genetic tests related to Microvascular Complications of Diabetes 2:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 2 29 EPO

Anatomical Context for Microvascular Complications of Diabetes 2

MalaCards organs/tissues related to Microvascular Complications of Diabetes 2:

41
Endothelial, Eye, Retina, Monocytes, Kidney, Liver, Heart

Publications for Microvascular Complications of Diabetes 2

Articles related to Microvascular Complications of Diabetes 2:

(show top 50) (show all 1018)
# Title Authors Year
1
Evaluation of TGF-Beta 2 and VEGF<i>I+</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes. ( 29850215 )
2018
2
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. ( 29351334 )
2018
3
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
4
The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus. ( 30531682 )
2018
5
Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy. ( 29739359 )
2018
6
Association of Abnormal Renal Profiles and Proliferative Diabetic Retinopathy and Diabetic Macular Edema in an Asian Population With Type 2 Diabetes. ( 29167896 )
2018
7
Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy. ( 29643784 )
2018
8
Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy. ( 30532517 )
2018
9
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment in Eyes with Proliferative Diabetic Retinopathy. ( 30524755 )
2018
10
INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES. ( 30148749 )
2018
11
Role of combined phacoemulsification and intravitreal injection of bevacizumab in prevention of postoperative macular edema in non-proliferative diabetic retinopathy. ( 30197955 )
2018
12
Ranibizumab Plus Panretinal Photocoagulation versus Panretinal Photocoagulation Alone for High-Risk Proliferative Diabetic Retinopathy (PROTEUS Study). ( 29395119 )
2018
13
BIMANUAL MICROINCISION VITREOUS SURGERY FOR SEVERE PROLIFERATIVE DIABETIC RETINOPATHY: OUTCOME IN MORE THAN 300 EYES. ( 29406470 )
2018
14
Plasma metabolic profile reveals PGF2α protecting against non-proliferative diabetic retinopathy in patients with type 2 diabetes. ( 29408756 )
2018
15
Region-specific ischemia, neovascularization and macular oedema in treatment-naïve proliferative diabetic retinopathy. ( 29412501 )
2018
16
Observation of neovascularization of the disc associated with proliferative diabetic retinopathy using OCT angiography. ( 29460018 )
2018
17
Observation of optic disc neovascularization using OCT angiography in proliferative diabetic retinopathy after intravitreal conbercept injections. ( 29507304 )
2018
18
The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization. ( 29536540 )
2018
19
Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis. ( 29541006 )
2018
20
Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation. ( 29542045 )
2018
21
Different lasers and techniques for proliferative diabetic retinopathy. ( 29543992 )
2018
22
Cost Evaluation of Laser versus Intravitreal Aflibercept for Proliferative Diabetic Retinopathy. ( 29571831 )
2018
23
Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections. ( 29606377 )
2018
24
Cost Evaluation of Early Vitrectomy versus Panretinal Photocoagulation and Intravitreal Ranibizumab for Proliferative Diabetic Retinopathy. ( 29606379 )
2018
25
The Correlation between Changes in Biochemical Parameters and Central Macular Thickness in Patients with Non-Proliferative Diabetic Retinopathy. ( 29644239 )
2018
26
Rethinking Management Strategies for Proliferative Diabetic Retinopathy. ( 29664976 )
2018
27
Risk factors for requirement of filtration surgery after vitrectomy in patients with proliferative diabetic retinopathy. ( 29713141 )
2018
28
Correction to: Electroretinogram evaluation for the treatment of proliferative diabetic retinopathy by short-pulse pattern scanning laser panretinal photocoagulation. ( 29744753 )
2018
29
Free amino acids hydroxyproline, lysine, and glycine promote differentiation of retinal pericytes to adipocytes: A protective role against proliferative diabetic retinopathy. ( 29752946 )
2018
30
Successful Midterm Management With an Herbal Decoction, Modified-Goshajinkigan (mGJG) for Non-Proliferative Diabetic Retinopathy: A Case Study. ( 29793732 )
2018
31
Subacute Vision Loss in a Young Pregnant Patient With Proliferative Diabetic Retinopathy. ( 29799966 )
2018
32
Characteristics of Neovascularization in Early Stages of Proliferative Diabetic Retinopathy by Optical Coherence Tomography Angiography. ( 29806991 )
2018
33
Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. ( 29850212 )
2018
34
Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy. ( 29853773 )
2018
35
Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy. ( 29940965 )
2018
36
Correlation Between Vitreous Advanced Glycation End Products, and D-dimer with Blood HbA1c Levels in Proliferative Diabetic Retinopathy. ( 29950532 )
2018
37
Soloist performance of vitrectomy probe in proliferative diabetic retinopathy. ( 29972027 )
2018
38
Panretinal Photocoagulation Versus Ranibizumab for Proliferative Diabetic Retinopathy: Factors Associated with Vision and Edema Outcomes. ( 29980333 )
2018
39
Reversal of Retinal Vascular Leakage and Arrest of Progressive Retinal Nonperfusion With Monthly Anti-Vascular Endothelial Growth Factor Therapy for Proliferative Diabetic Retinopathy. ( 30005003 )
2018
40
Leucine-rich G Protein-coupled Receptor-5 Is Significantly Increased in the Aqueous Humor of Human Eye with Proliferative Diabetic Retinopathy. ( 30022875 )
2018
41
Intraoperative OCT-assisted Surgery for Proliferative Diabetic Retinopathy in the DISCOVER Study. ( 30035245 )
2018
42
Five-Year Outcomes of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. ( 30043039 )
2018
43
Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy. ( 30046459 )
2018
44
Effect of intravitreal conbercept treatment before vitrectomy in proliferative diabetic retinopathy. ( 30046542 )
2018
45
Peripheral capillary non-perfusion in treatment-naïve proliferative diabetic retinopathy associates with postoperative disease activity 6 months after panretinal photocoagulation. ( 30068515 )
2018
46
Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti-Vascular Endothelial Growth Factor. ( 30077614 )
2018
47
Rationale and Application of the Protocol S Anti-Vascular Endothelial Growth Factor Algorithm for Proliferative Diabetic Retinopathy. ( 30096354 )
2018
48
Nomogram for prediction of non-proliferative diabetic retinopathy in juvenile-onset type 1 diabetes: a cohort study in an Asian population. ( 30111889 )
2018
49
Proliferative diabetic retinopathy imaged by near-infrared reflectance. ( 30115497 )
2018
50
Paracentral Acute Middle Maculopathy following Vitrectomy for Proliferative Diabetic Retinopathy: Incidence, Risk Factors, and Clinical Characteristics. ( 30126649 )
2018

Variations for Microvascular Complications of Diabetes 2

ClinVar genetic disease variations for Microvascular Complications of Diabetes 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 EPO NM_000799.3(EPO): c.-1306C> A single nucleotide variant risk factor rs1617640 GRCh37 Chromosome 7, 100317298: 100317298
2 EPO NM_000799.3(EPO): c.-1306C> A single nucleotide variant risk factor rs1617640 GRCh38 Chromosome 7, 100719675: 100719675

Expression for Microvascular Complications of Diabetes 2

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 2.

Pathways for Microvascular Complications of Diabetes 2

GO Terms for Microvascular Complications of Diabetes 2

Sources for Microvascular Complications of Diabetes 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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