MCID: MCR112
MIFTS: 33

Microvascular Complications of Diabetes 2

Categories: Genetic diseases, Nephrological diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 2

MalaCards integrated aliases for Microvascular Complications of Diabetes 2:

Name: Microvascular Complications of Diabetes 2 57 75 29 13 6 40
Proliferative Diabetic Retinopathy 75 73
Diabetic Nephropathy 75 73
Mvcd2 57 75
Microvascular Complications of Diabetes, Susceptibility to, 2 57
Proliferative Retinopathy, Diabetic, Susceptibility to 57
End-Stage Renal Disease, Diabetic, Susceptibility to 57
Proliferative Retinopathy, Diabetic 57
End-Stage Renal Disease, Diabetic 57
Diabetic End-Stage Renal Disease 75

Classifications:



External Ids:

OMIM 57 612623
MeSH 44 D048909
UMLS 73 C0011881

Summaries for Microvascular Complications of Diabetes 2

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 2: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 2, also known as proliferative diabetic retinopathy, is related to microvascular complications of diabetes 3 and microvascular complications of diabetes 7. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). Affiliated tissues include endothelial, eye and monocytes.

Description from OMIM: 612623

Related Diseases for Microvascular Complications of Diabetes 2

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 3 11.6
2 microvascular complications of diabetes 7 11.5
3 microvascular complications of diabetes 1 11.4

Symptoms & Phenotypes for Microvascular Complications of Diabetes 2

Clinical features from OMIM:

612623

Drugs & Therapeutics for Microvascular Complications of Diabetes 2

Genetic Tests for Microvascular Complications of Diabetes 2

Genetic tests related to Microvascular Complications of Diabetes 2:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 2 29 EPO

Anatomical Context for Microvascular Complications of Diabetes 2

MalaCards organs/tissues related to Microvascular Complications of Diabetes 2:

41
Endothelial, Eye, Monocytes, Placenta, Retina, Tongue, Myeloid

Publications for Microvascular Complications of Diabetes 2

Articles related to Microvascular Complications of Diabetes 2:

(show top 50) (show all 627)
# Title Authors Year
1
Evaluation of TGF-Beta 2 and VEGF<i>I+</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes. ( 29850215 )
2018
2
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. ( 29351334 )
2018
3
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
4
Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy. ( 29643784 )
2018
5
NONHEREDITARY IDIOPATHIC FOVEAL RETINOSCHISIS ASSOCIATED WITH NEW-ONSET PROLIFERATIVE DIABETIC RETINOPATHY. ( 29176525 )
2017
6
Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy. ( 28272234 )
2017
7
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy. ( 27860331 )
2017
8
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study. ( 28446148 )
2017
9
A case of pseudoxanthoma elasticum with proliferative diabetic retinopathy. ( 28978321 )
2017
10
Serous retinal detachment after panretinal photocoagulation for proliferative diabetic retinopathy: a case report. ( 28923115 )
2017
11
Association of IL-6 Gene (-174 and -572 G/C) Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Population. ( 28651253 )
2017
12
MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. ( 28571008 )
2017
13
The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. ( 28973045 )
2017
14
Association of functional SNP-1562C&amp;gt;T in MMP9 promoter with proliferative diabetic retinopathy in north Indian type 2 diabetes mellitus patients. ( 28964682 )
2017
15
Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes. ( 26940815 )
2016
16
Association of Complement C5 Gene Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Han Population. ( 26934706 )
2016
17
Preoperative intravitreal injection of ranibizumab for patients with severe proliferative diabetic retinopathy contributes to a decreased risk of postoperative neovascular glaucoma. ( 27010230 )
2016
18
Tumor necrosis factor-like weak inducer of apoptosis association with proliferative diabetic retinopathy and promotes proliferation and collagen synthesis in retinal ARPE-19 cells. ( 27050952 )
2016
19
Association between FNDC5 genetic variants and proliferative diabetic retinopathy in a Chinese population. ( 26926664 )
2016
20
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy. ( 26039997 )
2015
21
Painless Indirect Argon Laser in High Risk Proliferative Diabetic Retinopathy. ( 25902110 )
2015
22
Progression to macula-off tractional retinal detachment after a contralateral intraoperative intravitreal bevacizumab injection for proliferative diabetic retinopathy. ( 25784784 )
2015
23
High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with proliferative diabetic retinopathy. ( 25822410 )
2015
24
Role of NF-I_B activation and VEGF gene polymorphisms in VEGF up regulation in non-proliferative and proliferative diabetic retinopathy. ( 25956512 )
2015
25
Multimodal Characterization of Proliferative Diabetic Retinopathy Reveals Alterations in Outer Retinal Function and Structure. ( 25601533 )
2015
26
Increase of Sialylated N-Glycansin Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy. ( 26177396 )
2015
27
The -308G&amp;gt;a polymorphism of the TNF gene is associated with proliferative diabetic retinopathy in Caucasian Brazilians with type 2 diabetes. ( 25634985 )
2015
28
Expression of intraocular peroxisome proliferator-activated receptor gamma in patients with proliferative diabetic retinopathy. ( 25468312 )
2015
29
Progression to macula-off tractional retinal detachment after a contralateral intraoperative intravitreal bevacizumab injection for proliferative diabetic retinopathy. ( 25609907 )
2015
30
Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy. ( 27215012 )
2015
31
The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy. ( 25676319 )
2015
32
The angiogenic biomarker endocan is upregulated in proliferative diabetic retinopathy and correlates with vascular endothelial growth factor. ( 24871583 )
2015
33
Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular oedema. ( 25631486 )
2015
34
Genetic algorithm based feature selection combined with dual classification for the automated detection of proliferative diabetic retinopathy. ( 25841182 )
2015
35
Re: Role of combined cataract surgery and ranibizumab injection in postoperative macula edema in non-proliferative diabetic retinopathy. ( 25635581 )
2015
36
Programmed Death 1 (PD-1) is involved in the development of proliferative diabetic retinopathy by mediating activation-induced apoptosis. ( 26321864 )
2015
37
Upregulated Expression of Heparanase in the Vitreous of Patients With Proliferative Diabetic Retinopathy Originates From Activated Endothelial Cells and Leukocytes. ( 26720478 )
2015
38
Social deprivation as a risk factor for late presentation of proliferative diabetic retinopathy. ( 25733801 )
2015
39
The effects of pleiotrophin in proliferative diabetic retinopathy. ( 25617851 )
2015
40
The rs3917779 polymorphism of P-selectin's significant association with proliferative diabetic retinopathy in Yazd, Iran. ( 26344728 )
2015
41
Pan-retinal photocoagulation and other forms of laser treatment and drug therapies for non-proliferative diabetic retinopathy: systematic review and economic evaluation. ( 26173799 )
2015
42
Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy. ( 25899460 )
2015
43
Elevated LRP6 levels correlate with vascular endothelial growth factor in the vitreous of proliferative diabetic retinopathy. ( 26120271 )
2015
44
Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy. ( 25686060 )
2015
45
CHRONIC MYELOID LEUKEMIA DIAGNOSED IN A PATIENT WITH UNCONTROLLED PROLIFERATIVE DIABETIC RETINOPATHY. ( 25719936 )
2015
46
Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy. ( 25604687 )
2015
47
Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). ( 25637870 )
2015
48
Surgical management of retinal diseases: proliferative diabetic retinopathy and traction retinal detachment. ( 25196770 )
2014
49
Effect of sulodexide in patients with non-proliferative diabetic retinopathy: diabetic retinopathy sulodexide study (DRESS). ( 25112845 )
2014
50
Vitreous and plasma VEGF levels as predictive factors in the progression of proliferative diabetic retinopathy after vitrectomy. ( 25329921 )
2014

Variations for Microvascular Complications of Diabetes 2

ClinVar genetic disease variations for Microvascular Complications of Diabetes 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 EPO NM_000799.3(EPO): c.-1306C> A single nucleotide variant risk factor rs1617640 GRCh37 Chromosome 7, 100317298: 100317298
2 EPO NM_000799.3(EPO): c.-1306C> A single nucleotide variant risk factor rs1617640 GRCh38 Chromosome 7, 100719675: 100719675

Expression for Microvascular Complications of Diabetes 2

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 2.

Pathways for Microvascular Complications of Diabetes 2

GO Terms for Microvascular Complications of Diabetes 2

Sources for Microvascular Complications of Diabetes 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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