MVCD3
MCID: MCR113
MIFTS: 57

Microvascular Complications of Diabetes 3 (MVCD3)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 3

MalaCards integrated aliases for Microvascular Complications of Diabetes 3:

Name: Microvascular Complications of Diabetes 3 57 75 29 13 6 38
Diabetic Nephropathy 38 76 75 37 73
Mvcd3 57 75
Microvascular Complications of Diabetes, Susceptibility to, 3 57
End-Stage Renal Disease, Diabetic, Susceptibility to 57
Nephropathy, Diabetic, Susceptibility to 57
End-Stage Renal Disease, Diabetic 57
Diabetic End-Stage Renal Disease 75
Diabetic Nephropathies 55
Nephropathy, Diabetic 57

Classifications:



External Ids:

OMIM 57 612624
MeSH 44 D048909
KEGG 37 H01456
UMLS 73 C0011881

Summaries for Microvascular Complications of Diabetes 3

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 3: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 3, also known as diabetic nephropathy, is related to microvascular complications of diabetes 5 and hyperglycemia. An important gene associated with Microvascular Complications of Diabetes 3 is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Renin-angiotensin system. Affiliated tissues include Kidney, kidney and endothelial, and related phenotype is renal/urinary system.

Wikipedia : 76 Diabetic nephropathy (DN), also known as diabetic kidney disease, is the chronic loss of kidney function... more...

Description from OMIM: 612624

Related Diseases for Microvascular Complications of Diabetes 3

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 31.5 ACE AGTR1 ALB INS
2 hyperglycemia 30.2 ALB INS MALAT1
3 diabetes mellitus, noninsulin-dependent 30.1 ACE AGT AGTR1 ALB INS PVT1
4 stroke, ischemic 29.9 ACE AGTR1 MALAT1
5 interstitial nephritis 29.8 ACE AGT ALB
6 diabetes mellitus, insulin-dependent 29.7 ACE ALB INS PVT1
7 coronary heart disease 1 29.6 ACE AGTR1 INS
8 heart disease 29.6 ACE AGTR1 ALB INS
9 lipoid nephrosis 29.6 ALB NPHS1
10 malignant hypertension 29.5 ACE AGT AGTR1
11 membranous nephropathy 29.5 ACE ALB NPHS1
12 familial hypertension 29.5 AGT AGTR1
13 myeloma, multiple 29.5 ALB MALAT1 PVT1
14 iga glomerulonephritis 29.5 ACE AGTR1 ALB NPHS1
15 membranoproliferative glomerulonephritis 29.5 ALB NPHS1
16 hypertension, essential 29.4 ACE AGT AGTR1 ALB INS
17 maturity-onset diabetes of the young, type 1 29.4 ACE ALB INS
18 arteries, anomalies of 29.4 ACE AGT AGTR1 ALB INS
19 nephrosclerosis 29.3 ACE AGTR1 NPHS1
20 focal segmental glomerulosclerosis 29.3 ACE ALB NPHS1
21 end stage renal failure 29.2 ACE AGT AGTR1 ALB NPHS1
22 kidney disease 29.0 ACE AGT AGTR1 ALB INS NPHS1
23 chronic kidney failure 28.7 ACE AGT AGTR1 ALB CNDP1 INS
24 diabetes mellitus 28.6 ACE AGT AGTR1 ALB INS MALAT1
25 atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease 12.1
26 microvascular complications of diabetes 4 11.7
27 microvascular complications of diabetes 6 11.7
28 microvascular complications of diabetes 7 11.7
29 microvascular complications of diabetes 2 11.7
30 microvascular complications of diabetes 1 11.5
31 feigenbaum bergeron richardson syndrome 11.1
32 diabetic angiopathy 11.1
33 glomerulonephritis 10.2
34 pediatric hypertension 10.2 ACE AGT
35 neuropathy 10.2
36 loeffler syndrome 10.2 ACE ALB
37 orthostatic proteinuria 10.1 ACE ALB
38 syndrome of inappropriate antidiuretic hormone 10.1 ACE ALB
39 klatskin's tumor 10.1 ALB MALAT1
40 hepatorenal syndrome 10.1 ACE ALB
41 renovascular hypertension 10.1 ACE AGTR1
42 idiopathic edema 10.1 ACE INS
43 malignant glioma 10.1 PVT1 SNHG18
44 meningococcal infection 10.1 AGT AGTR1
45 acute mountain sickness 10.1 ACE AGTR1
46 noma 10.0 ALB INS
47 vascular disease 10.0
48 hyperuricemia 10.0
49 hypoxia 10.0
50 intermittent claudication 10.0 ACE ALB

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 3:



Diseases related to Microvascular Complications of Diabetes 3

Symptoms & Phenotypes for Microvascular Complications of Diabetes 3

Clinical features from OMIM:

612624

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 3:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 ACE AGT AGTR1 ALB INS NPHS1

Drugs & Therapeutics for Microvascular Complications of Diabetes 3

Search Clinical Trials , NIH Clinical Center for Microvascular Complications of Diabetes 3

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Microvascular Complications of Diabetes 3:
Mesenchymal precursor cells for type 2 diabetes
Embryonic/Adult Cultured Cells Related to Microvascular Complications of Diabetes 3:
Mesenchymal Precursor Cells (STRO-3 selected)

Genetic Tests for Microvascular Complications of Diabetes 3

Genetic tests related to Microvascular Complications of Diabetes 3:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 3 29 ACE

Anatomical Context for Microvascular Complications of Diabetes 3

MalaCards organs/tissues related to Microvascular Complications of Diabetes 3:

41
Kidney, Endothelial, Monocytes, Heart, Bone, Liver, Pancreas
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 3:
# Tissue Anatomical CompartmentCell Relevance
1 Kidney Podocyte Layer Podocytes Affected by disease, potential therapeutic candidate

Publications for Microvascular Complications of Diabetes 3

Articles related to Microvascular Complications of Diabetes 3:

(show top 50) (show all 2479)
# Title Authors Year
1
Expression of inflammasome complex mRNA and its targeted microRNA in type 2 diabetes mellitus: A possible predictor of the severity of diabetic nephropathy. ( 30151904 )
2019
2
Dibenzoylmethane ameliorates lipid-induced inflammation and oxidative injury in diabetic nephropathy. ( 30475214 )
2019
3
Kaempferol attenuates diabetic nephropathy by inhibiting RhoA/Rho-kinase mediated inflammatory signalling. ( 30551415 )
2019
4
Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats. ( 30551545 )
2019
5
Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-β1. ( 30054916 )
2019
6
Nine hub genes as the potential indicator for the clinical outcome of diabetic nephropathy. ( 30078220 )
2019
7
Transforming growth factor-β1 in children with diabetic nephropathy. ( 30136104 )
2019
8
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways. ( 30191967 )
2019
9
Haplotypes in vitamin D receptor gene encode risk in diabetic nephropathy. ( 30315926 )
2019
10
Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy. ( 28864059 )
2018
11
Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. ( 29966984 )
2018
12
FGF23<sup>C-tail</sup> improves diabetic nephropathy by attenuating renal fibrosis and inflammation. ( 29843712 )
2018
13
Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. ( 29845659 )
2018
14
MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. ( 29932921 )
2018
15
Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy. ( 29334763 )
2018
16
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). ( 29372470 )
2018
17
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-I_B signaling pathways in diabetic nephropathy. ( 29795979 )
2018
18
Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetic patients with diabetic nephropathy. ( 30516352 )
2018
19
Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy. ( 30472145 )
2018
20
The association between the red cell distribution width and diabetic nephropathy in patients with type-2 diabetes mellitus. ( 30371119 )
2018
21
Association of Circulating Vitamin D, VDBP, and Vitamin D Receptor Expression with Severity of Diabetic Nephropathy in a Group of Saudi Type 2 Diabetes Mellitus Patients. ( 30336516 )
2018
22
Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus. ( 30300472 )
2018
23
Thyroid stimulating hormone and free triiodothyronine are valuable predictors for diabetic nephropathy in patient with type 2 diabetes mellitus. ( 30211193 )
2018
24
Effect of topiroxostat in patients with diabetic nephropathy and gout or hyperuricemia: fact or fallacy. ( 29453606 )
2018
25
Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Excretion: A Retrospective Clinical Study. ( 30525055 )
2018
26
Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation. ( 29710532 )
2018
27
THYROID HORMONE REPLACEMENT REDUCES THE RISK OF CARDIOVASCULAR DISEASES IN DIABETIC NEPHROPATHY PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM. ( 29547051 )
2018
28
The effect of L-thyroxine substitution on oxidative stress in early-stage diabetic nephropathy patients with subclinical hypothyroidism: a randomized double-blind and placebo-controlled study. ( 29196928 )
2018
29
Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2. ( 30345618 )
2018
30
Deficiency of hypoxia inducible factor-1α promoted progression of diabetic nephropathy with hypertension. ( 30233722 )
2018
31
Validation of the 2007 kidney disease outcomes quality initiative clinical practice guideline for the diagnosis of diabetic nephropathy and nondiabetic renal disease in Chinese patients. ( 30472256 )
2018
32
Serum and Urinary SOD3 in Patients with Type 2 Diabetes: Comparison with Early Chronic Kidney Disease and Association with Development of Diabetic Nephropathy. ( 30303710 )
2018
33
Correlation Between Different Stages of Diabetic Nephropathy and Neuropathy in Patients with T2DM: A Cross-Sectional Controlled Study. ( 30302722 )
2018
34
Declining trends of diabetic nephropathy, retinopathy and neuropathy with improving diabetes care indicators in Japanese patients with type 2 and type 1 diabetes (JDDM 46). ( 29892340 )
2018
35
Association of vitamin D deficiency with diabetic peripheral neuropathy and diabetic nephropathy in Tianjin, China. ( 29737807 )
2018
36
Correlation analysis of urine proteins and inflammatory cytokines with osteoporosis in patients with diabetic nephropathy. ( 30179212 )
2018
37
Immune thrombocytopenic purpura presenting in a patient after renal transplant for diabetic nephropathy. ( 29554892 )
2018
38
lncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy. ( 30121551 )
2018
39
miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy. ( 30125566 )
2018
40
Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy. ( 30425061 )
2018
41
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy. ( 30425453 )
2018
42
Renal cortical stiffness obtained by shear wave elastography imaging is increased in patients with type 2 diabetes mellitus without diabetic nephropathy. ( 30051234 )
2018
43
Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus. ( 30072956 )
2018
44
Utility of urinary biomarkers as a diagnostic tool for early diabetic nephropathy in patients with type 2 diabetes mellitus. ( 29673928 )
2018
45
Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients. ( 29626590 )
2018
46
M1/M2 Macrophages in Diabetic Nephropathy: Nrf2/HO-1 as Therapeutic Targets. ( 30014796 )
2018
47
Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways. ( 29161661 )
2018
48
Down-regulation of IRAK1 attenuates podocyte apoptosis in diabetic nephropathy through PI3K/Akt signaling pathway. ( 30361091 )
2018
49
Serum Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9/ Neutrophil Gelatinase-associated Lipocalin Complex Levels in Patients With Early-stage Diabetic Nephropathy. ( 30367022 )
2018
50
Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy. ( 30369376 )
2018

Variations for Microvascular Complications of Diabetes 3

ClinVar genetic disease variations for Microvascular Complications of Diabetes 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
2 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh38 Chromosome 17, 63488531: 63488532

Expression for Microvascular Complications of Diabetes 3

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 3.

Pathways for Microvascular Complications of Diabetes 3

Pathways related to Microvascular Complications of Diabetes 3 according to KEGG:

37
# Name Kegg Source Accession
1 AGE-RAGE signaling pathway in diabetic complications hsa04933
2 Renin-angiotensin system hsa04614
3 FoxO signaling pathway hsa04068
4 Longevity regulating pathway hsa04211

GO Terms for Microvascular Complications of Diabetes 3

Biological processes related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.65 ACE AGT AGTR1
2 positive regulation of protein tyrosine kinase activity GO:0061098 9.58 ACE AGT
3 blood vessel remodeling GO:0001974 9.58 ACE AGT
4 positive regulation of reactive oxygen species metabolic process GO:2000379 9.57 AGT AGTR1
5 positive regulation of blood vessel diameter GO:0097755 9.56 AGT INS
6 positive regulation of blood pressure GO:0045777 9.55 ACE AGT
7 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.54 AGT INS
8 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.52 AGT AGTR1
9 low-density lipoprotein particle remodeling GO:0034374 9.51 AGT AGTR1
10 regulation of blood vessel diameter GO:0097746 9.49 ACE AGTR1
11 positive regulation of cholesterol esterification GO:0010873 9.46 AGT AGTR1
12 positive regulation of NAD(P)H oxidase activity GO:0033864 9.43 AGT AGTR1
13 regulation of renal sodium excretion GO:0035813 9.4 AGT AGTR1
14 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGT AGTR1
15 regulation of vasoconstriction GO:0019229 9.33 ACE AGT AGTR1
16 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.32 AGT AGTR1
17 regulation of renal output by angiotensin GO:0002019 9.26 ACE AGT
18 positive regulation of cellular protein metabolic process GO:0032270 9.13 AGT AGTR1 INS
19 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE AGT AGTR1

Molecular functions related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxypeptidase activity GO:0004180 8.96 ACE CNDP1
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Microvascular Complications of Diabetes 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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