MCID: MCR113
MIFTS: 52

Microvascular Complications of Diabetes 3

Categories: Genetic diseases, Nephrological diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 3

MalaCards integrated aliases for Microvascular Complications of Diabetes 3:

Name: Microvascular Complications of Diabetes 3 57 75 29 13 6 38
Diabetic Nephropathy 38 76 75 37 73
Mvcd3 57 75
Microvascular Complications of Diabetes, Susceptibility to, 3 57
End-Stage Renal Disease, Diabetic, Susceptibility to 57
Nephropathy, Diabetic, Susceptibility to 57
End-Stage Renal Disease, Diabetic 57
Diabetic End-Stage Renal Disease 75
Diabetic Nephropathies 55
Nephropathy, Diabetic 57

Classifications:



External Ids:

OMIM 57 612624
MeSH 44 D048909
KEGG 37 H01456
UMLS 73 C0011881

Summaries for Microvascular Complications of Diabetes 3

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 3: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 3, also known as diabetic nephropathy, is related to microvascular complications of diabetes 5 and atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease. An important gene associated with Microvascular Complications of Diabetes 3 is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Renin-angiotensin system. Affiliated tissues include Kidney, kidney and endothelial, and related phenotype is renal/urinary system.

Wikipedia : 76 Diabetic nephropathy (DN), also known as diabetic kidney disease, is the chronic loss of kidney function... more...

Description from OMIM: 612624

Related Diseases for Microvascular Complications of Diabetes 3

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 31.8 ACE AKR1B1 ALB INS
2 atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease 12.0
3 microvascular complications of diabetes 4 11.5
4 microvascular complications of diabetes 6 11.5
5 microvascular complications of diabetes 7 11.5
6 microvascular complications of diabetes 2 11.5
7 microvascular complications of diabetes 1 11.4
8 pediatric hypertension 10.9 ACE AGT
9 kidney cancer 10.7 MALAT1 MIR21 PVT1
10 renal artery disease 10.6 ACE AGTR1
11 severe nonproliferative diabetic retinopathy 10.6 ALB INS
12 orthostatic proteinuria 10.6 ACE ALB
13 interstitial nephritis 10.6 ACE AGT ALB
14 astrocytoma 10.6 MIR21 PVT1 SNHG18 SNHG6
15 posterior urethral valves 10.6 ACE AGT AGTR1
16 aortic coarctation 10.5 ACE AGT AGTR1
17 malignant hypertension 10.5 ACE AGT AGTR1
18 fibromuscular dysplasia 10.5 ACE AGT AGTR1
19 pancreatic ductal adenocarcinoma 10.5 MALAT1 MIR21 MIR217 PVT1
20 renal tubular dysgenesis 10.5 ACE AGT AGTR1
21 renal hypertension 10.5 ACE AGTR1 ALB
22 burns 10.5 ALB INS
23 ischemic optic neuropathy 10.5 ACE AGT AGTR1
24 hypertensive heart disease 10.5 ACE AGT AGTR1
25 oligohydramnios 10.5 ACE AGT AGTR1
26 mitral valve disease 10.5 ACE AGT AGTR1
27 glucose metabolism disease 10.5 ACE ALB INS
28 familial hypertension 10.5 AGT AGTR1
29 renal dysplasia 10.4 ACE AGT AGTR1
30 acquired metabolic disease 10.4 ACE ALB INS
31 otosclerosis 10.4 ACE AGT AGTR1
32 membranous nephropathy 10.4 ACE ALB NPHS1
33 thyroid cancer, nonmedullary, 1 10.4 MALAT1 MIR21 PVT1
34 nephrosclerosis 10.4 ACE AGTR1 CTGF
35 hepatorenal syndrome 10.4 ACE ALB NAGLU
36 pyelonephritis 10.3 ACE ALB NAGLU
37 diabetic neuropathy 10.3 ACE AKR1B1 INS
38 kidney hypertrophy 10.3 ALB CTGF NPHS1
39 autosomal dominant polycystic kidney disease 10.3 ACE AGT ALB
40 background diabetic retinopathy 10.2 ALB INS
41 anuria 10.2 ACE AGT AGTR1 ALB
42 vascular disease 10.2 ACE ALB INS MIR21
43 nasopharyngeal carcinoma 10.2 MALAT1 MIR192 MIR216A MIR217 PVT1
44 lipoid nephrosis 10.2 ALB NAGLU NPHS1
45 autonomic neuropathy 10.2 AKR1B1 ALB INS
46 clear cell renal cell carcinoma 10.1 MALAT1 MIR21 PVT1
47 diastolic heart failure 10.1 ACE AGT AGTR1 CTGF
48 gastric cancer 10.1 MALAT1 MIR192 MIR21 PVT1 SNHG6
49 esophageal cancer 10.1 ALB MALAT1 MIR192 MIR21 PVT1
50 vesicoureteral reflux 1 10.1 AGT AGTR1 NAGLU

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 3:



Diseases related to Microvascular Complications of Diabetes 3

Symptoms & Phenotypes for Microvascular Complications of Diabetes 3

Clinical features from OMIM:

612624

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 3:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.23 ACE AGT AGTR1 AKR1B1 ALB INS

Drugs & Therapeutics for Microvascular Complications of Diabetes 3

Search Clinical Trials , NIH Clinical Center for Microvascular Complications of Diabetes 3

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Microvascular Complications of Diabetes 3:
Mesenchymal precursor cells for type 2 diabetes
Embryonic/Adult Cultured Cells Related to Microvascular Complications of Diabetes 3:
Mesenchymal Precursor Cells (STRO-3 selected)

Genetic Tests for Microvascular Complications of Diabetes 3

Genetic tests related to Microvascular Complications of Diabetes 3:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 3 29 ACE

Anatomical Context for Microvascular Complications of Diabetes 3

MalaCards organs/tissues related to Microvascular Complications of Diabetes 3:

41
Kidney, Endothelial, Monocytes, Bone, Heart, Liver, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 3:
# Tissue Anatomical CompartmentCell Relevance
1 Kidney Podocyte Layer Podocytes Potential therapeutic candidate, affected by disease

Publications for Microvascular Complications of Diabetes 3

Articles related to Microvascular Complications of Diabetes 3:

(show top 50) (show all 1537)
# Title Authors Year
1
Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy. ( 28864059 )
2018
2
Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. ( 29966984 )
2018
3
FGF23<sup>C-tail</sup> improves diabetic nephropathy by attenuating renal fibrosis and inflammation. ( 29843712 )
2018
4
Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. ( 29845659 )
2018
5
MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. ( 29932921 )
2018
6
Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy. ( 29334763 )
2018
7
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). ( 29372470 )
2018
8
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-I_B signaling pathways in diabetic nephropathy. ( 29795979 )
2018
9
The association between interleukin-19 concentration and diabetic nephropathy. ( 28201997 )
2017
10
Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. ( 28934365 )
2017
11
Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. ( 28667184 )
2017
12
Serum obestatin and omentin levels in patients with diabetic nephropathy. ( 28091434 )
2017
13
MicroRNA-27a promotes podocyte injury via PPARI^-mediated I^-catenin activation in diabetic nephropathy. ( 28277542 )
2017
14
ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy. ( 28325697 )
2017
15
Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis. ( 28851298 )
2017
16
Clinical Implication of Cystatin C and I^2-Microglobulin in Early Detection of Diabetic Nephropathy. ( 28182344 )
2017
17
Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation. ( 28726774 )
2017
18
NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy. ( 28137583 )
2017
19
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice. ( 28767064 )
2017
20
Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy. ( 28748894 )
2017
21
Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients. ( 28326331 )
2017
22
Maximum home blood pressure is a useful indicator of diabetic nephropathy in patients with type 2 diabetes mellitus: KAMOGAWA-HBP study. ( 28819987 )
2017
23
NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients. ( 28631886 )
2017
24
Cardiac troponin T elevation at dialysis initiation is associated with all-cause and cardiovascular mortality on dialysis in patients without diabetic nephropathy. ( 27178276 )
2017
25
AR C-106T gene polymorphism and diabetic nephropathy in the Eastern Asians with T2DM: A meta-analysis including 2120 subjects. ( 28651212 )
2017
26
Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy. ( 28119515 )
2017
27
Lysine 63 ubiquitination is involved in the progression of tubular damage in diabetic nephropathy. ( 27881486 )
2017
28
Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy. ( 28356293 )
2017
29
Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy. ( 28668213 )
2017
30
High levels of circulating TNFR1 increase the risk of all-cause mortality and progression of renal disease in type 2 diabetic nephropathy. ( 27003829 )
2017
31
RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction. ( 28704853 )
2017
32
Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model. ( 28805484 )
2017
33
Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. ( 28289043 )
2017
34
Urinary heme oxygenase-1 as a potential biomarker for early diabetic nephropathy. ( 26733347 )
2017
35
NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus. ( 28620620 )
2017
36
Function of NLRP3 in the Pathogenesis and Development of Diabetic Nephropathy. ( 28798291 )
2017
37
The <i>CNDP1</i> (CTG)<sub>5</sub> Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration. ( 28553654 )
2017
38
Paraoxonase 1 polymorphisms (L55M and Q192R) as a genetic marker of diabetic nephropathy in youth with type 1 diabetes. ( 26884296 )
2017
39
EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress. ( 28427241 )
2017
40
ApoM/HDL-C and apoM/apoA-I ratios are indicators of diabetic nephropathy in healthy controls and type 2 diabetes mellitus. ( 28073663 )
2017
41
Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. ( 28246612 )
2017
42
The Impact of Peroxisome Proliferator-Activated Receptor Gamma and Its Interaction with Abdominal Obesity on Diabetic Nephropathy in Chinese Han. ( 28013303 )
2017
43
Resistin-Like Molecule Beta (RELM-I^) Regulates Proliferation of Human Diabetic Nephropathy Mesangial Cells via Mitogen-Activated Protein Kinases (MAPK) Signaling Pathway. ( 28801998 )
2017
44
Multi-glycoside of Tripterygium wilfordii Hook.A f. attenuates glomerulosclerosis in a rat model of diabetic nephropathy by exerting anti-microinflammatory effects without affecting hyperglycemia. ( 28731135 )
2017
45
Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population. ( 28246355 )
2017
46
Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes - preliminary results of a family-based study. ( 28255976 )
2017
47
Association of irisin and FNDC5 rs16835198 G&amp;gt;T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study. ( 28479383 )
2017
48
Effects of Bone Marrow Mesenchymal Stem Cells on Plasminogen Activator Inhibitor-1 and Renal Fibrosis in Rats with Diabetic Nephropathy. ( 27018336 )
2016
49
Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy. ( 25814621 )
2016
50
Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes. ( 27083286 )
2016

Variations for Microvascular Complications of Diabetes 3

ClinVar genetic disease variations for Microvascular Complications of Diabetes 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
2 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh38 Chromosome 17, 63488531: 63488532

Expression for Microvascular Complications of Diabetes 3

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 3.

Pathways for Microvascular Complications of Diabetes 3

Pathways related to Microvascular Complications of Diabetes 3 according to KEGG:

37
# Name Kegg Source Accession
1 AGE-RAGE signaling pathway in diabetic complications hsa04933
2 Renin-angiotensin system hsa04614
3 FoxO signaling pathway hsa04068
4 Longevity regulating pathway hsa04211

Pathways related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.03 ACE AGT AGTR1
2 10.61 ACE AGT AGTR1

GO Terms for Microvascular Complications of Diabetes 3

Cellular components related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ACE AGT AKR1B1 ALB CTGF INS

Biological processes related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.76 AGT MIR21 MIR217
2 kidney development GO:0001822 9.75 ACE AGT AGTR1
3 regulation of cell growth GO:0001558 9.7 AGT AGTR1 CTGF
4 positive regulation of inflammatory response GO:0050729 9.69 AGT AGTR1 MIR21
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 AGT INS MIR21
6 positive regulation of cardiac muscle hypertrophy GO:0010613 9.61 AGT MIR21
7 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.61 AGT MIR21
8 tissue homeostasis GO:0001894 9.6 AKR1B1 CTGF
9 positive regulation of glucose import in response to insulin stimulus GO:2001275 9.59 AGT INS
10 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.57 AGT AGTR1
11 regulation of blood vessel diameter GO:0097746 9.56 ACE AGTR1
12 low-density lipoprotein particle remodeling GO:0034374 9.55 AGT AGTR1
13 angiotensin maturation GO:0002003 9.54 ACE AGT
14 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.49 INS MIR21
15 positive regulation of cholesterol esterification GO:0010873 9.48 AGT AGTR1
16 positive regulation of NAD(P)H oxidase activity GO:0033864 9.43 AGT AGTR1
17 regulation of renal sodium excretion GO:0035813 9.4 AGT AGTR1
18 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGT AGTR1
19 regulation of vasoconstriction GO:0019229 9.33 ACE AGT AGTR1
20 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.32 AGT AGTR1
21 regulation of renal output by angiotensin GO:0002019 9.26 ACE AGT
22 positive regulation of cellular protein metabolic process GO:0032270 9.13 AGT AGTR1 INS
23 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE AGT AGTR1

Molecular functions related to Microvascular Complications of Diabetes 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxypeptidase activity GO:0004180 8.96 ACE CNDP1
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Microvascular Complications of Diabetes 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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