MVCD4
MCID: MCR133
MIFTS: 43

Microvascular Complications of Diabetes 4 (MVCD4)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 4

MalaCards integrated aliases for Microvascular Complications of Diabetes 4:

Name: Microvascular Complications of Diabetes 4 57 75 29 13 6 40
Diabetic Nephropathy 75 73
Mvcd4 57 75
Microvascular Complications of Diabetes, Susceptibility to, 4 57
Nephropathy, Diabetic, Susceptibility to 57
Nephropathy, Diabetic 57

Classifications:



External Ids:

OMIM 57 612628
MeSH 44 D048909
UMLS 73 C0011881

Summaries for Microvascular Complications of Diabetes 4

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 4: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 4, also known as diabetic nephropathy, is related to atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease and microvascular complications of diabetes 3. An important gene associated with Microvascular Complications of Diabetes 4 is IL1RN (Interleukin 1 Receptor Antagonist). Affiliated tissues include kidney, endothelial and monocytes.

Description from OMIM: 612628

Related Diseases for Microvascular Complications of Diabetes 4

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease 12.1
2 microvascular complications of diabetes 3 11.9
3 microvascular complications of diabetes 6 11.7
4 microvascular complications of diabetes 7 11.7
5 microvascular complications of diabetes 1 11.3
6 microvascular complications of diabetes 5 11.3
7 microvascular complications of diabetes 2 11.1
8 feigenbaum bergeron richardson syndrome 11.1
9 diabetic angiopathy 11.1
10 diabetes mellitus, noninsulin-dependent 10.6
11 end stage renal failure 10.3
12 glomerulonephritis 10.2
13 hyperglycemia 10.2
14 neuropathy 10.2
15 kidney disease 10.1
16 hypertension, essential 10.0
17 vascular disease 10.0
18 hyperuricemia 10.0
19 hypoxia 10.0
20 arteries, anomalies of 10.0
21 diabetes mellitus, insulin-dependent 10.0
22 chronic kidney failure 10.0
23 coronary artery anomaly 10.0
24 heart disease 10.0
25 iga glomerulonephritis 10.0
26 purpura 10.0
27 uremia 10.0
28 aging 9.9
29 stroke, ischemic 9.9
30 autonomic neuropathy 9.9
31 hypothyroidism 9.9
32 fatty liver disease 9.9
33 segmental odontomaxillary dysplasia 9.9
34 horns in sheep 9.8
35 coronary heart disease 1 9.8
36 fatty liver disease, nonalcoholic 1 9.8
37 muscle hypertrophy 9.8
38 membranous nephropathy 9.8
39 liver disease 9.8
40 pemphigus foliaceus 9.8
41 sleep apnea 9.8
42 interstitial nephritis 9.8
43 lipoid nephrosis 9.8
44 henoch-schoenlein purpura 9.8
45 nephrotic syndrome 9.8
46 arteriosclerosis 9.8
47 membranoproliferative glomerulonephritis 9.8
48 plasmacytoma 9.8
49 hypoaldosteronism 9.8
50 rapidly involuting congenital hemangioma 9.8

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 4:



Diseases related to Microvascular Complications of Diabetes 4

Symptoms & Phenotypes for Microvascular Complications of Diabetes 4

Clinical features from OMIM:

612628

Drugs & Therapeutics for Microvascular Complications of Diabetes 4

Genetic Tests for Microvascular Complications of Diabetes 4

Genetic tests related to Microvascular Complications of Diabetes 4:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 4 29 IL1RN

Anatomical Context for Microvascular Complications of Diabetes 4

MalaCards organs/tissues related to Microvascular Complications of Diabetes 4:

41
Kidney, Endothelial, Monocytes, Heart, Bone, Liver, Pancreas

Publications for Microvascular Complications of Diabetes 4

Articles related to Microvascular Complications of Diabetes 4:

(show top 50) (show all 2479)
# Title Authors Year
1
Expression of inflammasome complex mRNA and its targeted microRNA in type 2 diabetes mellitus: A possible predictor of the severity of diabetic nephropathy. ( 30151904 )
2019
2
Dibenzoylmethane ameliorates lipid-induced inflammation and oxidative injury in diabetic nephropathy. ( 30475214 )
2019
3
Kaempferol attenuates diabetic nephropathy by inhibiting RhoA/Rho-kinase mediated inflammatory signalling. ( 30551415 )
2019
4
Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats. ( 30551545 )
2019
5
Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-β1. ( 30054916 )
2019
6
Nine hub genes as the potential indicator for the clinical outcome of diabetic nephropathy. ( 30078220 )
2019
7
Transforming growth factor-β1 in children with diabetic nephropathy. ( 30136104 )
2019
8
DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways. ( 30191967 )
2019
9
Haplotypes in vitamin D receptor gene encode risk in diabetic nephropathy. ( 30315926 )
2019
10
Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy. ( 28864059 )
2018
11
Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. ( 29966984 )
2018
12
FGF23<sup>C-tail</sup> improves diabetic nephropathy by attenuating renal fibrosis and inflammation. ( 29843712 )
2018
13
Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. ( 29845659 )
2018
14
MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. ( 29932921 )
2018
15
Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy. ( 29334763 )
2018
16
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). ( 29372470 )
2018
17
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-I_B signaling pathways in diabetic nephropathy. ( 29795979 )
2018
18
Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetic patients with diabetic nephropathy. ( 30516352 )
2018
19
Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy. ( 30472145 )
2018
20
The association between the red cell distribution width and diabetic nephropathy in patients with type-2 diabetes mellitus. ( 30371119 )
2018
21
Association of Circulating Vitamin D, VDBP, and Vitamin D Receptor Expression with Severity of Diabetic Nephropathy in a Group of Saudi Type 2 Diabetes Mellitus Patients. ( 30336516 )
2018
22
Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus. ( 30300472 )
2018
23
Thyroid stimulating hormone and free triiodothyronine are valuable predictors for diabetic nephropathy in patient with type 2 diabetes mellitus. ( 30211193 )
2018
24
Effect of topiroxostat in patients with diabetic nephropathy and gout or hyperuricemia: fact or fallacy. ( 29453606 )
2018
25
Administration of RAS Inhibitor before the Onset of Diabetic Nephropathy Counteracts the Adverse Effect of Chronic Hyperglycemia and Reduces the Augmentation of Urinary Albumin Excretion: A Retrospective Clinical Study. ( 30525055 )
2018
26
Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation. ( 29710532 )
2018
27
THYROID HORMONE REPLACEMENT REDUCES THE RISK OF CARDIOVASCULAR DISEASES IN DIABETIC NEPHROPATHY PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM. ( 29547051 )
2018
28
The effect of L-thyroxine substitution on oxidative stress in early-stage diabetic nephropathy patients with subclinical hypothyroidism: a randomized double-blind and placebo-controlled study. ( 29196928 )
2018
29
Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2. ( 30345618 )
2018
30
Deficiency of hypoxia inducible factor-1α promoted progression of diabetic nephropathy with hypertension. ( 30233722 )
2018
31
Validation of the 2007 kidney disease outcomes quality initiative clinical practice guideline for the diagnosis of diabetic nephropathy and nondiabetic renal disease in Chinese patients. ( 30472256 )
2018
32
Serum and Urinary SOD3 in Patients with Type 2 Diabetes: Comparison with Early Chronic Kidney Disease and Association with Development of Diabetic Nephropathy. ( 30303710 )
2018
33
Correlation Between Different Stages of Diabetic Nephropathy and Neuropathy in Patients with T2DM: A Cross-Sectional Controlled Study. ( 30302722 )
2018
34
Declining trends of diabetic nephropathy, retinopathy and neuropathy with improving diabetes care indicators in Japanese patients with type 2 and type 1 diabetes (JDDM 46). ( 29892340 )
2018
35
Association of vitamin D deficiency with diabetic peripheral neuropathy and diabetic nephropathy in Tianjin, China. ( 29737807 )
2018
36
Correlation analysis of urine proteins and inflammatory cytokines with osteoporosis in patients with diabetic nephropathy. ( 30179212 )
2018
37
Immune thrombocytopenic purpura presenting in a patient after renal transplant for diabetic nephropathy. ( 29554892 )
2018
38
lncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy. ( 30121551 )
2018
39
miR-133b and miR-199b knockdown attenuate TGF-β1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy. ( 30125566 )
2018
40
Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy. ( 30425061 )
2018
41
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy. ( 30425453 )
2018
42
Renal cortical stiffness obtained by shear wave elastography imaging is increased in patients with type 2 diabetes mellitus without diabetic nephropathy. ( 30051234 )
2018
43
Combining SGLT2 Inhibition With a Thiazolidinedione Additively Attenuate the Very Early Phase of Diabetic Nephropathy Progression in Type 2 Diabetes Mellitus. ( 30072956 )
2018
44
Utility of urinary biomarkers as a diagnostic tool for early diabetic nephropathy in patients with type 2 diabetes mellitus. ( 29673928 )
2018
45
Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients. ( 29626590 )
2018
46
M1/M2 Macrophages in Diabetic Nephropathy: Nrf2/HO-1 as Therapeutic Targets. ( 30014796 )
2018
47
Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways. ( 29161661 )
2018
48
Down-regulation of IRAK1 attenuates podocyte apoptosis in diabetic nephropathy through PI3K/Akt signaling pathway. ( 30361091 )
2018
49
Serum Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9/ Neutrophil Gelatinase-associated Lipocalin Complex Levels in Patients With Early-stage Diabetic Nephropathy. ( 30367022 )
2018
50
Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy. ( 30369376 )
2018

Variations for Microvascular Complications of Diabetes 4

ClinVar genetic disease variations for Microvascular Complications of Diabetes 4:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IL1RN IL1RN, IVS2, 86-BP DUP duplication Pathogenic,risk factor

Expression for Microvascular Complications of Diabetes 4

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 4.

Pathways for Microvascular Complications of Diabetes 4

GO Terms for Microvascular Complications of Diabetes 4

Sources for Microvascular Complications of Diabetes 4

3 CDC
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