MVCD5
MCID: MCR115
MIFTS: 70

Microvascular Complications of Diabetes 5 (MVCD5)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Nephrological diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 5

MalaCards integrated aliases for Microvascular Complications of Diabetes 5:

Name: Microvascular Complications of Diabetes 5 57 75 29 13 6 38 40
Diabetic Retinopathy 38 12 37 29 55 44 15 73
Retinopathy, Diabetic 57 76
Diabetic Nephropathy 75 73
Mvcd5 57 75
Microvascular Complications of Diabetes, Susceptibility to, 5 57
Retinopathy, Diabetic, Susceptibility to 57
Retinal Abnormality - Diabetes-Related 12

Classifications:



External Ids:

OMIM 57 612633
Disease Ontology 12 DOID:8947
ICD9CM 35 362.0
NCIt 50 C34538
SNOMED-CT 68 4855003
MedGen 42 C2674665
KEGG 37 H01457
ICD10 33 H36.0

Summaries for Microvascular Complications of Diabetes 5

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 5: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to severe nonproliferative diabetic retinopathy and background diabetic retinopathy. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and HIF-1 signaling pathway. Affiliated tissues include Eye and Eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Diabetic retinopathy, also known as diabetic eye disease, is a medical condition in which damage occurs... more...

Description from OMIM: 612633

Related Diseases for Microvascular Complications of Diabetes 5

Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)
# Related Disease Score Top Affiliating Genes
1 severe nonproliferative diabetic retinopathy 34.0 ALB INS VEGFA
2 background diabetic retinopathy 33.9 ALB ANGPT2 INS VEGFA
3 microvascular complications of diabetes 1 32.5 AKR1B1 ANGPT2 FGF2 FLT1 ICAM1 IGF1
4 microvascular complications of diabetes 3 31.9 ACE ALB INS
5 kidney disease 31.2 ACE AGER AKR1B1 ALB INS NOS3
6 macular holes 30.6 ANGPT2 SERPINF1 VEGFA
7 retinal vein occlusion 30.5 SERPINE1 SERPINF1 VEGFA
8 macular dystrophy, dominant cystoid 30.5 PRKCB SERPINF1 VEGFA
9 leukostasis 30.4 ICAM1 KDR VCAM1 VEGFA
10 retinal vascular disease 30.4 ACE AKR1B1 ALB FLT1 ICAM1 INS
11 rubeosis iridis 30.3 IGF1 INS VEGFA
12 diabetes mellitus, noninsulin-dependent 30.3 ACE AGER AKR1B1 ALB IGF1 INS
13 hyperglycemia 30.2 AKR1B1 ALB IGF1 INS NOS3 PRKCB
14 autonomic neuropathy 30.2 AKR1B1 ALB INS
15 lipid metabolism disorder 30.1 ACE INS SERPINE1
16 diabetes mellitus, insulin-dependent 30.1 ACE AKR1B1 ALB IGF1 INS
17 coronary artery anomaly 30.1 ACE NOS3 PON1 SERPINE1
18 retinal artery occlusion 30.0 ACE SERPINE1 VEGFA
19 hypertension, essential 29.9 ACE ALB INS NOS3 PON1 SERPINE1
20 stroke, ischemic 29.9 ACE MIAT NOS3 PON1 SERPINE1
21 diabetic polyneuropathy 29.9 AGER AKR1B1 VEGFA
22 keratopathy 29.9 AKR1B1 IGF1 VCAM1
23 diabetic neuropathy 29.8 ACE AKR1B1 INS VEGFA
24 peripheral nervous system disease 29.8 AKR1B1 ALB INS
25 sleep apnea 29.8 ACE ICAM1 IGF1 INS NOS3
26 peripheral artery disease 29.8 ACE NOS3 VCAM1 VEGFA
27 coronary heart disease 1 29.7 ACE INS NOS3 PON1 SERPINE1
28 arteriosclerosis 29.7 ACE ICAM1 INS PON1 SERPINE1 VCAM1
29 chronic kidney failure 29.7 ACE ALB ICAM1 IGF1 INS NOS3
30 maturity-onset diabetes of the young, type 1 29.7 ACE ALB INS SERPINE1
31 epileptic encephalopathy, childhood-onset 29.6 ANGPT2 KDR SERPINE1 VEGFA
32 ischemia 29.6 ACE ICAM1 NOS3 PON1 VEGFA
33 myeloma, multiple 29.6 ALB FGF2 IGF1 VEGFA
34 macular degeneration, age-related, 1 29.6 FGF2 FLT1 KDR SERPINF1 VEGFA
35 heart disease 29.5 ACE ALB ICAM1 IGF1 INS NOS3
36 dilated cardiomyopathy 29.4 ACE ALB IGF1 MIAT NOS3 VCAM1
37 atherosclerosis susceptibility 29.4 ICAM1 INS NOS3 PON1 SERPINE1 VCAM1
38 body mass index quantitative trait locus 11 29.4 IGF1 INS NOS3 PON1 SERPINE1
39 diabetic macular edema 29.4 FGF2 ICAM1 NOS3 PRKCB SERPINF1 TEK
40 arteries, anomalies of 29.4 ACE ALB FLT1 ICAM1 INS NOS3
41 vascular disease 29.4 ACE AGER ALB FGF2 INS NOS3
42 exudative vitreoretinopathy 1 29.3 ANGPT2 FLT1 IGF1 KDR TEK VEGFA
43 pre-eclampsia 29.2 FLT1 ICAM1 KDR NOS3 SERPINE1 VCAM1
44 myocardial infarction 29.2 ACE AGER ALB ICAM1 INS MIAT
45 limb ischemia 29.1 ACE ANGPT2 FGF2 KDR NOS3 TEK
46 diabetes mellitus 29.1 ACE AGER AKR1B1 ALB IGF1 INS
47 breast cancer 28.5 FGF2 FLT1 IGF1 INS KDR MIAT
48 microvascular complications of diabetes 2 12.0
49 microvascular complications of diabetes 7 11.9
50 vitreoretinopathy, neovascular inflammatory 11.5

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 5:



Diseases related to Microvascular Complications of Diabetes 5

Symptoms & Phenotypes for Microvascular Complications of Diabetes 5

Clinical features from OMIM:

612633

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 5:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.51 ACE AGER ANGPT2 FGF2 FLT1 ICAM1
2 homeostasis/metabolism MP:0005376 10.48 ACE AGER AKR1B1 ALB ANGPT2 FGF2
3 hematopoietic system MP:0005397 10.41 ACE AGER FGF2 FLT1 ICAM1 IGF1
4 cellular MP:0005384 10.38 AGER ALB ANGPT2 FGF2 FLT1 ICAM1
5 growth/size/body region MP:0005378 10.36 ACE AGER AKR1B1 FLT1 ICAM1 IGF1
6 immune system MP:0005387 10.36 ACE AGER ANGPT2 FLT1 ICAM1 IGF1
7 mortality/aging MP:0010768 10.33 ACE AKR1B1 ALB ANGPT2 FGF2 FLT1
8 muscle MP:0005369 10.17 AGER ALB FGF2 FLT1 ICAM1 IGF1
9 nervous system MP:0003631 10.11 FGF2 FLT1 ICAM1 IGF1 INS KDR
10 digestive/alimentary MP:0005381 10.1 ALB ANGPT2 ICAM1 INS NOS3 SERPINF1
11 integument MP:0010771 10.1 AGER ANGPT2 ICAM1 IGF1 INS KDR
12 liver/biliary system MP:0005370 10.02 ACE ALB INS KDR NOS3 SERPINE1
13 normal MP:0002873 9.97 AGER ALB FLT1 IGF1 INS KDR
14 neoplasm MP:0002006 9.95 ACE ALB FGF2 ICAM1 IGF1 SERPINE1
15 renal/urinary system MP:0005367 9.91 ACE AGER AKR1B1 ALB IGF1 INS
16 reproductive system MP:0005389 9.81 ACE FGF2 FLT1 IGF1 INS NOS3
17 skeleton MP:0005390 9.61 AGER AKR1B1 FGF2 IGF1 INS KDR
18 vision/eye MP:0005391 9.36 AKR1B1 ANGPT2 FGF2 FLT1 ICAM1 INS

Drugs & Therapeutics for Microvascular Complications of Diabetes 5

Genetic Tests for Microvascular Complications of Diabetes 5

Genetic tests related to Microvascular Complications of Diabetes 5:

# Genetic test Affiliating Genes
1 Diabetic Retinopathy 29
2 Microvascular Complications of Diabetes 5 29 PON1

Anatomical Context for Microvascular Complications of Diabetes 5

MalaCards organs/tissues related to Microvascular Complications of Diabetes 5:

41
Eye, Endothelial, Retina, Bone, Testes, Kidney, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 5:
# Tissue Anatomical CompartmentCell Relevance
1 Eye Outer Nuclear Layer Mature L Cone Cells Affected by disease, potential therapeutic candidate
2 Eye Outer Nuclear Layer Mature M Cone Cells Affected by disease, potential therapeutic candidate
3 Eye Inner Nuclear Layer Mature Muller Glia Cells Affected by disease
4 Eye Outer Nuclear Layer Mature Rod Cells Affected by disease, potential therapeutic candidate
5 Eye Outer Nuclear Layer Mature S Cone Cells Affected by disease, potential therapeutic candidate

Publications for Microvascular Complications of Diabetes 5

Articles related to Microvascular Complications of Diabetes 5:

(show top 50) (show all 3100)
# Title Authors Year
1
Pathological Perturbations in Diabetic Retinopathy: Hyperglycemia, AGEs, Oxidative Stress and Inflammatory Pathways. ( 30264677 )
2019
2
A non-invasive, multi-target approach to treat diabetic retinopathy. ( 30551523 )
2019
3
Early detection of diabetic retinopathy with flicker electroretinography, proteomics, and oximetry. ( 30092247 )
2019
4
Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment. ( 29877085 )
2018
5
Venous beading in two or more quadrants might not be a sensitive grading criterion for severe nonproliferative diabetic retinopathy. ( 29626228 )
2018
6
Evaluation of TGF-Beta 2 and VEGF<i>I+</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes. ( 29850215 )
2018
7
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. ( 29351334 )
2018
8
Basis and Design of a Randomized Clinical Trial to Evaluate the Effect of Levosulpiride on Retinal Alterations in Patients With Diabetic Retinopathy and Diabetic Macular Edema. ( 29896154 )
2018
9
ASYMMETRIC DIABETIC RETINOPATHY PROGRESSION IN PATIENTS WITH AXIAL ANISOMETROPIA. ( 29547453 )
2018
10
Prevalence of diabetic retinopathy and diabetic macular edema in a primary care-based teleophthalmology program for American Indians and Alaskan Natives. ( 29924846 )
2018
11
Successful Management of Proliferative Diabetic Retinopathy and Multiple Choroidal Tubercles in a Patient with Miliary Tuberculosis. ( 29719654 )
2018
12
PHACOEMULSIFICATION CATARACT SURGERY WITH PROPHYLACTIC INTRAVITREAL BEVACIZUMAB FOR PATIENTS WITH COEXISTING DIABETIC RETINOPATHY: A Meta-Analysis. ( 29975344 )
2018
13
Development of diabetic retinopathy after cataract surgery. ( 30133506 )
2018
14
Re: Singh et al.: Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: results of 2 randomized phase 3 studies (Ophthalmology. 2017;124:776-785). ( 29268871 )
2018
15
Re: Singh et al.: Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: results of 2 randomized phase 3 studies (Ophthalmology. 2017;124:776-785). ( 29268873 )
2018
16
Re: Singh et al.: Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: result of 2 randomized phase 3 studies (Ophthalmology. 2017;124:776-785). ( 29268877 )
2018
17
The Association of Serum Leptin Level and Anthropometric Measures With the Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus. ( 30505866 )
2018
18
The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus. ( 30531682 )
2018
19
Polymorphisms of Aldose Reductase (ALR2) Regulatory Gene are Risk Factors for Diabetic Retinopathy in Type-2 Diabetes Mellitus Patients in Bali, Indonesia. ( 30450144 )
2018
20
QUANTITATIVE AND QUALITATIVE ANALYSIS OF THE THREE CAPILLARY PLEXUSES AND CHORIOCAPILLARIS IN PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES MELLITUS WITHOUT CLINICAL SIGNS OF DIABETIC RETINOPATHY: A Prospective Pilot Study. ( 30358764 )
2018
21
Non-mydriatic ultrawide field scanning laser ophthalmoscopy compared with dilated fundal examination for assessment of diabetic retinopathy and diabetic macular oedema in Chinese individuals with diabetes mellitus. ( 30381391 )
2018
22
Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus. ( 30300472 )
2018
23
Combined effect of glycemic and blood pressure control on diabetic retinopathy among Chinese with type-2 diabetes mellitus. ( 30302129 )
2018
24
Risk factors for development and progression of diabetic retinopathy in Dutch patients with type 1 diabetes mellitus. ( 30188024 )
2018
25
Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-A novel OCT based imaging biomarker. ( 30533048 )
2018
26
Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy. ( 29739359 )
2018
27
CHANGES IN DIABETIC RETINOPATHY SEVERITY WHEN TREATING DIABETIC MACULAR EDEMA WITH RANIBIZUMAB: DRCR.net Protocol I 5-Year Report. ( 30234859 )
2018
28
Baseline Factors Affecting Changes in Diabetic Retinopathy Severity Scale Score After Intravitreal Aflibercept or Laser for Diabetic Macular Edema: Post Hoc Analyses from VISTA and VIVID. ( 28764888 )
2018
29
Association of Abnormal Renal Profiles and Proliferative Diabetic Retinopathy and Diabetic Macular Edema in an Asian Population With Type 2 Diabetes. ( 29167896 )
2018
30
Abnormally low Bispectral index and severe hypoglycemia during maintenance of and recovery from general anesthesia in diabetic retinopathy surgery: two case reports. ( 29678142 )
2018
31
Time-dependent changes in hypoxia- and gliosis-related factors in experimental diabetic retinopathy. ( 30401898 )
2018
32
A longitudinal study of serum insulin-like growth factor-I levels over 6 years in a large cohort of children and adolescents with type 1 diabetes mellitus: A marker reflecting diabetic retinopathy. ( 29663652 )
2018
33
Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy. ( 29630532 )
2018
34
Clinical Efficacy and Safety of the EX-PRESS Filtration Device in Patients with Advanced Neovascular Glaucoma and Proliferative Diabetic Retinopathy. ( 29643784 )
2018
35
Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy. ( 30532517 )
2018
36
Association between Diabetic Retinopathy and Chronic Periodontitis-A Cross-Sectional Study. ( 30477167 )
2018
37
COMBINED VITRECTOMY WITH INTRAVITREAL DEXAMETHASONE IMPLANT FOR REFRACTORY MACULAR EDEMA SECONDARY TO DIABETIC RETINOPATHY, RETINAL VEIN OCCLUSION, AND NONINFECTIOUS POSTERIOR UVEITIS. ( 30312262 )
2018
38
Psoriasis risk in patients with diabetic retinopathy: A nationwide population-based study. ( 29904118 )
2018
39
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment in Eyes with Proliferative Diabetic Retinopathy. ( 30524755 )
2018
40
INCREASED COMPLEMENT LEVELS IN HUMAN VITREOUS ASPIRATES OF PROLIFERATIVE DIABETIC RETINOPATHY AND RETINAL DETACHMENT EYES. ( 30148749 )
2018
41
Tractional Retinal Detachment Secondary to Diabetic Retinopathy. ( 30326076 )
2018
42
Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview. ( 29721943 )
2018
43
New Evidence Showing yet another Link between Sight-Threatening Diabetic Retinopathy and Obstructive Sleep Apnea: How Relevant is this to my General Practice? ( 30369389 )
2018
44
Diabetic retinopathy is associated with the presence and burden of subclinical carotid atherosclerosis in type 1 diabetes. ( 29728117 )
2018
45
Diabetic retinopathy screening in incident diabetes mellitus type 2 in Germany between 2004 and 2013 - A prospective cohort study based on health claims data. ( 29621309 )
2018
46
Optical coherence tomography angiography findings of neurovascular changes in type 2 diabetes mellitus patients without clinical diabetic retinopathy. ( 30066044 )
2018
47
The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus. ( 30103306 )
2018
48
The Association between Pancreatic Steatosis and Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients. ( 30113148 )
2018
49
Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus. ( 29849828 )
2018
50
Diabetic retinopathy and health-related quality of life among Chinese with known type 2 diabetes mellitus. ( 29740784 )
2018

Variations for Microvascular Complications of Diabetes 5

ClinVar genetic disease variations for Microvascular Complications of Diabetes 5:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PON1 NM_000446.6(PON1): c.163T> A (p.Leu55Met) single nucleotide variant risk factor rs854560 GRCh37 Chromosome 7, 94946084: 94946084
2 PON1 NM_000446.6(PON1): c.163T> A (p.Leu55Met) single nucleotide variant risk factor rs854560 GRCh38 Chromosome 7, 95316772: 95316772

Expression for Microvascular Complications of Diabetes 5

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 5.

Pathways for Microvascular Complications of Diabetes 5

Pathways related to Microvascular Complications of Diabetes 5 according to KEGG:

37
# Name Kegg Source Accession
1 AGE-RAGE signaling pathway in diabetic complications hsa04933
2 HIF-1 signaling pathway hsa04066
3 Renin-angiotensin system hsa04614

Pathways related to Microvascular Complications of Diabetes 5 according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 ANGPT2 FGF2 FLT1 ICAM1 IGF1 INS
2
Show member pathways
13.42 ANGPT2 FGF2 FLT1 IGF1 KDR NOS3
3
Show member pathways
13.32 ALB ANGPT2 IGF1 NOS3 PRKCB SERPINE1
4
Show member pathways
13.31 ANGPT2 FGF2 FLT1 IGF1 KDR PRKCB
5
Show member pathways
13.28 FGF2 FLT1 IGF1 KDR NOS3 PRKCB
6
Show member pathways
13.01 ACE FGF2 FLT1 IGF1 INS KDR
7
Show member pathways
12.93 ANGPT2 FGF2 FLT1 IGF1 INS KDR
8
Show member pathways
12.78 FGF2 IGF1 KDR PRKCB VEGFA
9
Show member pathways
12.75 FGF2 ICAM1 KDR SERPINE1 VCAM1
10
Show member pathways
12.71 FGF2 FLT1 IGF1 KDR PRKCB
11 12.69 ANGPT2 FGF2 FLT1 IGF1 INS KDR
12
Show member pathways
12.66 ICAM1 KDR NOS3 PRKCB VCAM1 VEGFA
13
Show member pathways
12.62 ANGPT2 FGF2 FLT1 IGF1 INS KDR
14
Show member pathways
12.51 FLT1 IGF1 INS KDR PRKCB
15
Show member pathways
12.44 FLT1 KDR NOS3 PRKCB
16
Show member pathways
12.43 FLT1 KDR NOS3 PRKCB VEGFA
17
Show member pathways
12.4 FGF2 FLT1 IGF1 KDR TEK
18
Show member pathways
12.39 FGF2 FLT1 KDR VEGFA
19
Show member pathways
12.36 ICAM1 KDR NOS3 PRKCB VCAM1 VEGFA
20
Show member pathways
12.34 ALB ICAM1 INS SERPINE1
21 12.31 FGF2 IGF1 KDR PRKCB VEGFA
22
Show member pathways
12.29 FGF2 FLT1 IGF1 KDR PRKCB
23
Show member pathways
12.19 FGF2 FLT1 KDR NOS3 PRKCB VEGFA
24 12.14 ANGPT2 FGF2 FLT1 KDR TEK
25 12.09 ICAM1 KDR NOS3 VCAM1 VEGFA
26
Show member pathways
12.07 ANGPT2 FGF2 FLT1 ICAM1 IGF1 KDR
27 12 FGF2 ICAM1 VCAM1 VEGFA
28 11.92 ALB FGF2 IGF1 INS KDR VCAM1
29
Show member pathways
11.89 FLT1 KDR NOS3 VEGFA
30 11.87 ICAM1 PRKCB VCAM1
31 11.87 FLT1 ICAM1 TEK VEGFA
32
Show member pathways
11.83 FLT1 KDR NOS3 PRKCB
33 11.83 ANGPT2 FGF2 FLT1 KDR NOS3 TEK
34 11.79 FGF2 IGF1 VEGFA
35 11.7 AGER INS NOS3 PRKCB
36 11.7 AGER ICAM1 NOS3 PRKCB SERPINE1 VCAM1
37 11.69 FGF2 IGF1 VEGFA
38
Show member pathways
11.67 ICAM1 VCAM1 VEGFA
39 11.58 FGF2 IGF1 INS KDR
40 11.56 FGF2 KDR VEGFA
41 11.53 FGF2 KDR VEGFA
42 11.52 FGF2 IGF1 INS VEGFA
43 11.51 ICAM1 NOS3 VCAM1
44
Show member pathways
11.47 INS KDR VEGFA
45 11.43 FGF2 FLT1 KDR VEGFA
46 11.41 IGF1 INS PRKCB
47 11.41 ANGPT2 SERPINE1 VEGFA
48 11.37 ICAM1 PRKCB VCAM1
49 11.31 FLT1 KDR SERPINE1 VEGFA
50 11.28 ANGPT2 FLT1 IGF1 INS NOS3 PRKCB

GO Terms for Microvascular Complications of Diabetes 5

Cellular components related to Microvascular Complications of Diabetes 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ACE AKR1B1 ALB ICAM1 PON1 PRKCB
2 extracellular region GO:0005576 9.8 ACE AGER ALB ANGPT2 FGF2 FLT1
3 extracellular space GO:0005615 9.47 ACE AKR1B1 ALB ANGPT2 FGF2 FLT1
4 platelet alpha granule lumen GO:0031093 9.46 ALB IGF1 SERPINE1 VEGFA

Biological processes related to Microvascular Complications of Diabetes 5 according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 ACE IGF1 KDR SERPINF1 VEGFA
2 positive regulation of protein phosphorylation GO:0001934 9.96 AGER KDR TEK VEGFA
3 positive regulation of cell migration GO:0030335 9.96 FLT1 IGF1 INS KDR VEGFA
4 peptidyl-tyrosine phosphorylation GO:0018108 9.95 FGF2 FLT1 KDR TEK
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 AGER ICAM1 INS PRKCB
6 extracellular matrix organization GO:0030198 9.93 FGF2 ICAM1 KDR SERPINE1 VCAM1
7 platelet degranulation GO:0002576 9.89 ALB IGF1 SERPINE1 VEGFA
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 AGER FGF2 FLT1 ICAM1 KDR TEK
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.86 FLT1 KDR TEK
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ICAM1 IGF1 VEGFA
11 positive regulation of MAPK cascade GO:0043410 9.85 FLT1 IGF1 INS KDR TEK
12 positive regulation of MAP kinase activity GO:0043406 9.84 FGF2 FLT1 VEGFA
13 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.83 FLT1 KDR VEGFA
14 positive regulation of endothelial cell migration GO:0010595 9.82 KDR TEK VEGFA
15 positive regulation of endothelial cell proliferation GO:0001938 9.81 FGF2 KDR TEK VEGFA
16 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.79 FGF2 KDR VEGFA
17 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.77 ICAM1 NOS3 SERPINE1
18 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.76 FGF2 FLT1 TEK
19 positive regulation of focal adhesion assembly GO:0051894 9.74 KDR TEK VEGFA
20 positive regulation of blood vessel endothelial cell migration GO:0043536 9.73 FGF2 KDR NOS3 VEGFA
21 response to hypoxia GO:0001666 9.73 AGER ANGPT2 ICAM1 TEK VCAM1 VEGFA
22 cell migration involved in sprouting angiogenesis GO:0002042 9.72 FGF2 KDR VEGFA
23 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.7 FLT1 PRKCB VEGFA
24 induction of positive chemotaxis GO:0050930 9.68 AGER VEGFA
25 negative regulation of calcium ion transport GO:0051926 9.68 ICAM1 NOS3
26 negative regulation of wound healing GO:0061045 9.68 FGF2 SERPINE1
27 positive regulation of phospholipase C activity GO:0010863 9.68 FGF2 FLT1
28 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
29 vascular endothelial growth factor signaling pathway GO:0038084 9.67 FLT1 KDR VEGFA
30 negative regulation of endothelial cell apoptotic process GO:2000352 9.67 ICAM1 KDR SERPINE1 TEK
31 membrane to membrane docking GO:0022614 9.64 ICAM1 VCAM1
32 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.64 KDR VEGFA
33 glomerulus vasculature development GO:0072012 9.63 ANGPT2 TEK
34 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.62 ACE VEGFA
35 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.62 FLT1 KDR VCAM1 VEGFA
36 Tie signaling pathway GO:0048014 9.61 ANGPT2 TEK
37 angiogenesis GO:0001525 9.56 ANGPT2 FGF2 FLT1 KDR NOS3 SERPINE1
38 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.55 FLT1 IGF1 INS KDR TEK
39 positive regulation of angiogenesis GO:0045766 9.28 ANGPT2 FGF2 FLT1 KDR NOS3 PRKCB
40 positive regulation of cell proliferation GO:0008284 10.09 FGF2 FLT1 IGF1 INS KDR VEGFA
41 regulation of signaling receptor activity GO:0010469 10.06 FGF2 IGF1 INS SERPINE1 VEGFA
42 negative regulation of apoptotic process GO:0043066 10.02 AKR1B1 ALB FLT1 IGF1 KDR TEK

Molecular functions related to Microvascular Complications of Diabetes 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.56 FGF2 FLT1 KDR TEK
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 FLT1 KDR TEK
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 FLT1 KDR
4 transmembrane signaling receptor activity GO:0004888 9.35 AGER FLT1 ICAM1 KDR TEK
5 growth factor binding GO:0019838 9.33 FLT1 KDR TEK
6 integrin binding GO:0005178 9.02 FGF2 ICAM1 IGF1 KDR VCAM1

Sources for Microvascular Complications of Diabetes 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....