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MVCD5
MCID: MCR115
MIFTS: 66

Microvascular Complications of Diabetes 5 (MVCD5)

Categories: Cardiovascular diseases, Eye diseases, Genetic diseases, Nephrological diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Microvascular Complications of Diabetes 5

About this section

MalaCards integrated aliases for Microvascular Complications of Diabetes 5:

Name: Microvascular Complications of Diabetes 5 56 73 29 13 6 37 39
Diabetic Retinopathy 12 36 29 54 43 15 17 71 32
Retinopathy, Diabetic 56 74
Diabetic Nephropathy 73 71
Mvcd5 56 73
Microvascular Complications of Diabetes, Susceptibility to, 5 56
Retinopathy, Diabetic, Susceptibility to 56
Retinal Abnormality - Diabetes-Related 12

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Eye diseases Cardiovascular diseases Neuronal diseases Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8947
OMIM 56 612633
OMIM Phenotypic Series 56 PS603933
KEGG 36 H01457
ICD9CM 34 362.0
NCIt 49 C34538
SNOMED-CT 67 4855003
ICD10 32 H36.0
MedGen 41 C2674665
UMLS 71 C0011881 C0011884
Sources

Summaries for Microvascular Complications of Diabetes 5

About this section
KEGG : 36 Diabetic retinopathy (DR), one of the most common vascular complication of diabetes, is the leading cause of visual deficits and blindness around the world. The development of DR is divided into two stages: in the early stages, also called as nonproliferative stage, it is asymptomatic because the signs are not visible to the eye. however, some defects including microaneurysms, intraretinal hemorrhaging, narrowing or blocked retinal blood vessels can be seen by detection; in the second stage, known as proliferative diabetic retinopathy, where neovascularization appears at the back of the eye and extend into the vitreous of the eye, and these new blood vessels are fragile. If they leak blood, the bleeding causes shrinkage of the retina, leading to retinal detachment, and ultimately to blindness. It has been reported that vascular endothelial growth factor A, angiotensin-converting enzyme, paraoxonase, erythropoietin are associated with DR development and progression.

MalaCards based summary : Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to microvascular complications of diabetes 1 and microvascular complications of diabetes 3. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and HIF-1 signaling pathway. The drugs Diclofenac and Pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

UniProtKB/Swiss-Prot : 73 Microvascular complications of diabetes 5: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

Wikipedia : 74 Diabetic retinopathy, also known as diabetic eye disease, is a medical condition in which damage occurs... more...

More information from OMIM: 612633 PS603933
Sources

Related Diseases for Microvascular Complications of Diabetes 5

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Diseases in the Microvascular Complications of Diabetes 5 family:

Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 2
Microvascular Complications of Diabetes 3 Microvascular Complications of Diabetes 4
Microvascular Complications of Diabetes 6 Microvascular Complications of Diabetes 7

Diseases related to Microvascular Complications of Diabetes 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 772)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 1 33.8 VEGFA SERPINF1 PRKCB INS IGF1 ICAM1
2 microvascular complications of diabetes 3 33.2 INS ALB AKR1B1 AGER ACE
3 maturity-onset diabetes of the young, type 1 32.8 INS ALB ACE
4 diabetes mellitus, noninsulin-dependent 32.5 VEGFA SERPINE1 PRKCB PON1 PGF NOS3
5 retinal detachment 32.4 VEGFA SERPINF1 IGF1 FGF2
6 kidney hypertrophy 31.6 INS ALB ACE
7 retinal vein occlusion 31.6 VEGFA SERPINF1 SERPINE1 KDR ANGPT2 ACE
8 endophthalmitis 31.5 VEGFA PGF ICAM1 FLT1 ALB
9 hypercholesterolemia, familial, 1 31.4 NOS3 INS ACE
10 homocysteinemia 31.4 SERPINE1 PON1 NOS3 ALB
11 coronary heart disease 1 31.3 SERPINE1 PON1 NOS3 INS ACE
12 hypertensive nephropathy 31.3 VEGFA ALB ACE
13 kidney disease 31.3 SERPINE1 PRKCB PON1 NOS3 INS ALB
14 central retinal vein occlusion 31.3 VEGFA SERPINF1 PGF
15 keratopathy 31.3 IGF1 ICAM1 AKR1B1
16 diabetic cataract 31.2 VEGFA SERPINF1 INS AKR1B1
17 peripheral vascular disease 31.2 VEGFA SERPINE1 NOS3 INS ALB ACE
18 macular dystrophy, dominant cystoid 31.2 VEGFA SERPINF1 PRKCB ACE
19 ischemia 31.2 VEGFA TEK PON1 NOS3 KDR ICAM1
20 acute cystitis 31.1 INS ALB ACE
21 chronic kidney disease 31.1 VEGFA SERPINE1 PON1 NOS3 INS IGF1
22 hyperglycemia 31.1 SERPINE1 PRKCB NOS3 INS IGF1 ALB
23 polycystic kidney disease 31.1 VEGFA NOS3 ALB ACE
24 carotid stenosis 31.1 VEGFA NOS3 ICAM1 ACE
25 hypothyroidism 31.1 VEGFA SERPINE1 PON1 INS IGF1 ALB
26 arteries, anomalies of 31.0 VEGFA SERPINE1 NOS3 INS ICAM1 ALB
27 renal hypertension 31.0 NOS3 ALB ACE
28 glucose intolerance 31.0 SERPINE1 INS IGF1 ALB ACE
29 cerebrovascular disease 31.0 SERPINE1 PON1 INS ICAM1 AGER ACE
30 kuhnt-junius degeneration 31.0 VEGFA TEK PGF KDR FLT1 ANGPT2
31 gestational diabetes 31.0 PGF INS IGF1 ALB
32 deficiency anemia 31.0 PON1 INS IGF1 ALB ACE
33 atherosclerosis susceptibility 31.0 VEGFA SERPINE1 PON1 NOS3 INS ICAM1
34 macular retinal edema 31.0 VEGFA SERPINF1 PRKCB PGF KDR INS
35 exanthem 30.9 VEGFA KDR ALB ACE
36 retinal microaneurysm 30.9 VEGFA INS AKR1B1
37 lipoprotein quantitative trait locus 30.9 VEGFA SERPINE1 PON1 NOS3 KDR ICAM1
38 congestive heart failure 30.9 VEGFA NOS3 INS ANGPT2 ALB ACE
39 hypertensive retinopathy 30.9 VEGFA ALB ACE
40 membranous nephropathy 30.8 ALB AKR1B1 ACE
41 angina pectoris 30.8 NOS3 INS ACE
42 systemic lupus erythematosus 30.8 VEGFA SERPINE1 PON1 NOS3 INS ICAM1
43 neovascular glaucoma 30.8 VEGFA PGF KDR FLT1 FGF2
44 diabetic macular edema 30.8 VEGFA TEK SERPINF1 PRKCB PGF NOS3
45 peripheral artery disease 30.8 VEGFA NOS3 IGF1 ICAM1 FGF2 ANGPT2
46 pyelonephritis 30.8 PGF ALB ACE
47 corneal disease 30.8 VEGFA FGF2 ALB AKR1B1
48 nonarteritic anterior ischemic optic neuropathy 30.8 VEGFA NOS3 ACE
49 cataract 30.8 VEGFA SERPINF1 INS IGF1 ICAM1 FGF2
50 sleep disorder 30.7 INS IGF1 ACE

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 5:



Diseases related to Microvascular Complications of Diabetes 5
Sources

Symptoms & Phenotypes for Microvascular Complications of Diabetes 5

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Clinical features from OMIM:

612633

MGI Mouse Phenotypes related to Microvascular Complications of Diabetes 5:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 ACE AGER ALB ANGPT2 FGF2 FLT1
2 homeostasis/metabolism MP:0005376 10.43 ACE AGER AKR1B1 ALB ANGPT2 FGF2
3 hematopoietic system MP:0005397 10.34 ACE AGER FGF2 FLT1 ICAM1 IGF1
4 immune system MP:0005387 10.33 ACE AGER ALB ANGPT2 FLT1 ICAM1
5 growth/size/body region MP:0005378 10.32 ACE AGER AKR1B1 FLT1 ICAM1 IGF1
6 cellular MP:0005384 10.3 AGER ALB ANGPT2 FGF2 FLT1 ICAM1
7 mortality/aging MP:0010768 10.25 ACE AKR1B1 ALB ANGPT2 FGF2 FLT1
8 muscle MP:0005369 10.11 AGER ALB FGF2 FLT1 ICAM1 IGF1
9 integument MP:0010771 10.09 AGER ANGPT2 ICAM1 IGF1 INS KDR
10 nervous system MP:0003631 10 FGF2 FLT1 ICAM1 IGF1 INS KDR
11 neoplasm MP:0002006 9.92 ACE ALB FGF2 ICAM1 IGF1 PGF
12 normal MP:0002873 9.81 AGER ALB FLT1 IGF1 INS KDR
13 renal/urinary system MP:0005367 9.61 ACE AGER AKR1B1 ALB IGF1 INS
14 vision/eye MP:0005391 9.4 AKR1B1 ANGPT2 FGF2 FLT1 ICAM1 INS
Sources

Drugs & Therapeutics for Microvascular Complications of Diabetes 5

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Drugs for Microvascular Complications of Diabetes 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 519)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
3
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
4
Zaleplon Approved, Illicit, Investigational Phase 4 151319-34-5 5719
5
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
6
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
7
Methyldopa Approved Phase 4 555-30-6 38853
8
Capsaicin Approved Phase 4 404-86-4 1548943
9
Ranibizumab Approved Phase 4 347396-82-1 459903
10
Bevacizumab Approved, Investigational Phase 4 216974-75-3
11
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
12
Copper Approved, Investigational Phase 4 7440-50-8 27099
13
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
14
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
15
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
16
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
17
Dipivefrin Approved Phase 4 52365-63-6 3105
18
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
19
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
20
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
21
Probucol Approved, Investigational Phase 4 23288-49-5 4912
22
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
23
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
24
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
25
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
26
Doxazosin Approved Phase 4 74191-85-8 3157
27
Atorvastatin Approved Phase 4 134523-00-5 60823
28
Indapamide Approved Phase 4 26807-65-8 3702
29
Nisoldipine Approved Phase 4 63675-72-9 4499
30
Verapamil Approved Phase 4 52-53-9 2520
31
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
32
Insulin glulisine Approved Phase 4 207748-29-6
33
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
34
Bromfenac Approved Phase 4 91714-94-2 60726
35
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
36
Insulin lispro Approved Phase 4 133107-64-9
37
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
38
Clonidine Approved Phase 4 4205-90-7 2803
39
Atenolol Approved Phase 4 29122-68-7 2249
40
Hydralazine Approved Phase 4 86-54-4 3637
41
Terazosin Approved Phase 4 63590-64-7 5401
42
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
43
Homatropine Approved Phase 4 87-00-3
44
Febuxostat Approved Phase 4 144060-53-7 134018
45
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
46
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
47
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
48
Enalaprilat Approved Phase 4 76420-72-9 6917719
49
Losartan Approved Phase 4 114798-26-4 3961
50
Canagliflozin Approved Phase 4 842133-18-0

Interventional clinical trials:

(show top 50) (show all 1243)
# Name Status NCT ID Phase Drugs
1 Panretinal Photocoagulation for Proliferative Diabetic Retinopathy in a Single Session Using Low Fluence Parameters Unknown status NCT01023698 Phase 4
2 Effects of Glatiramer Acetate (Copaxone) in the Nerve Fiber Layer Thickness and Retinal Function in Diabetic Patients After Pan- Retinal Photocoagulation (PRP), a Double- Masked Randomized Clinical Trial. Unknown status NCT00677664 Phase 4 Glatiramer acetate (Copaxone);Mannitol
3 The Effects of Thiazolidinedione on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
4 Effect of Aldosterone Antagonism in the Reduction of Albuminuria and Diastolic Disfunction of Patients With Diabetic Nephropathy. Unknown status NCT00870402 Phase 4 Spironolactone;Placebo
5 Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy Unknown status NCT01921192 Phase 4 Folic Acid, vit B6 and B12;Placebo
6 Effect of Doxium on High Sensitivity CRP and Endothelin-1 Serum Levels in Patients With Diabetic Retinopathy Unknown status NCT01382498 Phase 4 Calcium dobesilate (Doxium);Placebo drug
7 The Effect of Bevacizumab on Peripheral Retinal Changes as Imaged by Wide -Field Fluorescein Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
8 Effect of Sarpogrelate On the Nephropathy in Type 2 Diabetes Unknown status NCT01869881 Phase 4 Anplag(Sarpogrelate);Placebo
9 Effect of Intravenous and Oral Therapy With Sulodexide on Albuminuria in Type 2 Diabetic Patients Unknown status NCT01316068 Phase 4 intravenous use of sulodexide followed by oral use;use of sulodexide orally only
10 Clinical Trial Technology Development for the Validation of Surrogate Prognostic Markers in Patients With Diabetic Nephropathy Unknown status NCT01673204 Phase 4 Calcitriol;Placebo
11 Phase 4 Study of Mechanisms of Low Protein Diet Supplemented With Ketoanalogs on Reducing Proteinuria and Maintaining Nutritional Status in Type 2 Diabetic Nephropathy Unknown status NCT01300273 Phase 4
12 Safety of Add on Aliskiren to ACEI and ARB Treatment in Type 2 Diabetes With Nephropathy Unknown status NCT00949351 Phase 4 Aliskiren 300mg/d
13 Pilot Study Investigating the Use of Intravitreal Ranibizumab in the Treatment of Vitreous Hemorrhage in Proliferative Diabetic Retinopathy Unknown status NCT01824043 Phase 4 intravitreal ranibizumab injections
14 A Prospective, Randomized, Two Period, With an Intermediate Wash Out Period, Cross-over Study to Compare the Effects of Either Combined Therapy With Ramipril and Clopidogrel or Ramipril Monotherapy on Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Patients With Type 2 Diabetes and Diabetic Nephropathy Unknown status NCT01743014 Phase 4 Ramipril;Clopidogrel
15 A Pilot Study to Determine if Intravitreal Injections of Pegaptanib Sodium (Macugen) Given Every 12 Weeks for a Year After an Induction Phase of Three Injections Every 6 Weeks Will Reduce the Progression of Proliferative Diabetic Retinopathy in Patients Without Significant Vitreous Hemorrhage in Comparison to Treatment With Retinal Photocoagulation Alone and After an Induction Phase Unknown status NCT01486771 Phase 4 Macugen ® (pegaptanib sodium)
16 A Prospective, Open-label, Parallel, Controlled Study to Evaluate the Efficacy of Fenofibrate on Microalbuminuria in Hypertriglyceridemic Patients With Type 2 Diabetes on Top of Statin Therapy Unknown status NCT02314533 Phase 4 fenofibrate
17 Three Arm, Prospective, Single-blind, Randomized Study Comparing Ranibizumab Plus Green Diode Laser Versus Ranibizumab Plus Pattern Scan Laser (Pascal) Versus Ranibizumab (Monotherapy) for Proliferative Diabetic Retinopathy. Unknown status NCT02005432 Phase 4 Intravitreal Ranibizumabe;panfotocoagulation (PASCAL);panfotocoagulation (PRP) single shoot (ETDRS)
18 Different Day Regimes of Preoperative CONbercept Administration on CytokinEs of Proliferative Diabetic Retinopathy Patients Undergoing Vitrectomy: a Prospective Randomized Controlled Clinical Trial (CONCEPT) Unknown status NCT03506750 Phase 4 IVC
19 Phase 4 Comparison of the Effects of Bevacizumab Before vs After Pattern Panretinal Photocoagulation Unknown status NCT00804206 Phase 4 bevacizumab;bevacizumab
20 A Prospective, Randomised Controlled Trial of Ranibizumab Pre-treatment in Diabetic Vitrectomy - a Pilot Study Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
21 Sympathetic Nervous System Inhibition for the Treatment of Diabetic Nephropathy Unknown status NCT01094769 Phase 4 Moxonidine;Placebo
22 Safety and Efficacy of Shenyankangfu Tablets for Chronic Kidney Disease Unknown status NCT02885857 Phase 4 Shenyan Kangfu Tablet
23 Intensive Medical Treatment for Nephropathy Caused by Type 2 Diabetes With Hypertension Unknown status NCT00407680 Phase 4 Intensive therapy Valsartan,Fluvastatin
24 A Study on the Anti-proteinuric Effects of Pioglitazone in Patients With Type 2 Diabetes. Unknown status NCT00749047 Phase 4 Pioglitazone
25 Pattern Scan Laser System vs Regular Photocoagulation System: Changes in Macular Edema Post Treatment. Unknown status NCT00563628 Phase 4
26 Pattern Scan Laser System vs Regular Photocoagulation System: Changes in Electroretinograms and Contrast Sensitivity Post Treatment. Unknown status NCT00563043 Phase 4
27 Comparison Between ARB and ARB Plus CCB on Incidence of Renal and Cardiovascular Events in Hypertensive ADPKD Patients Unknown status NCT00541853 Phase 4 Candesartan;Candesartan and Cilnidipine;Candesartan plus non-CCB agents
28 Phase IV, Effect of Rennin-Angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria--- A Randomized Controlled Trial Unknown status NCT01500590 Phase 4 Renin-angiotensin system blockers;non-renin angiotensin system blockers
29 The Reduction of Microalbuminuria in Japanese Hypertensive Subjects With Type 2 Diabetes Mellitus Treated With Valsartan or Amlodipine: Study Design for the Shiga Microalbuminuria Reduction Trial (SMART) Unknown status NCT00202618 Phase 4 Valsartan;Amlodipine
30 Prevention of Renal Complications of Diabetes With Thiamine Unknown status NCT01725412 Phase 4
31 Intravitreal Diclofenac Versus Intravitreal Ranibizumab for the Treatment of Diabetic Macular Edema. Unknown status NCT03458923 Phase 4 Diclofenac Sodium 0.1 ml containing 500µg;Ranibizumab 0.5 mg Solution for Injection
32 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
33 Effect of Aflibercept (Eylea®) in the Management of Bevacizumab (Avastin®) Resistant Diabetic Macular Edema Unknown status NCT02924987 Phase 4 Aflibercept Injection
34 Management of Active and Established Corneal Neovascularisation to Prevent Visual Impairment Unknown status NCT02594423 Phase 4 Bevacizumab
35 The Role of Qutenza (Topical Capsaicin 8%) in Treating Neuropathic Pain From Critical Ischaemia in Patients With End-stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
36 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
37 A 12-months, Randomized, VA-assessor Blinded, Multicenter, Controlled Phase IV Trial to Investigate Noninferiority of Two Treatment Algorithms (Discretion of the Investigator vs. Pro re Nata) of 0.5 mg Ranibizumab in Patients With Visual Impairment Due to Diabetic Macula Edema Completed NCT02366468 Phase 4 ranibizumab 0.5 mg
38 An Open-label, Prospective, Multicentre, Uncontrolled, Proof of Concept Study Assessing the Efficacy of Lucentis (Ranibizumab) Administered by an Individualized "Treat and Extend" Dosing Regimen in Patients With Visual Impairment Due to Diabetic Macular Edema Completed NCT01297569 Phase 4 Ranibizumab
39 A Multicenter, Randomized, Double-blind Non-inferiority Trial to Evaluate the Efficacy and Safety of Entelon® as Compared to Doxium Tab. And Placebo for the Treatment of Nonproliferative Diabetic Retinopathy Completed NCT03962296 Phase 4 Vitis vinifera extract;Calcium Dobesilate;Placebo
40 Diabetic Macula Oedema. A Prospective Randomised Study Comparing the Detailed Functional and Anatomical Changes of Repeated Pan Anti-VEGF Therapy With Ranibizumab Versus Conventional Macular Laser Therapy. Completed NCT01223612 Phase 4 Ranibizumab
41 Pain Using Reduced Fluence Parameters in Photocoagulation for Diabetic Retinopathy. Completed NCT00802269 Phase 4
42 Intravitreal Bevacizumab for Surgical Treatment of Severe Proliferative Diabetic Retinopathy Completed NCT01025934 Phase 4 Bevacizumab
43 Topical Application of Latanoprost in Diabetic Retinopathy Completed NCT01225653 Phase 4 Latanoprost
44 Spironolactone in Diabetic Nephropathy Completed NCT00317954 Phase 4 Spironolactone
45 Evaluation of Diabetic Retinopathy Progression in Subjects With Type 2 Diabetes Mellitus Treated With Insulin Completed NCT00174824 Phase 4 Insulin glargine
46 Dexamethasone Intravitreal Implant (0.7mg) for the Treatment of Persistent Diabetic Macular Edema Following Intravitreal Anti-Vascular Endothelial Growth Factor Therapy Completed NCT02471651 Phase 4 Dexamethasone intravitreal implant (0.7 mg);Intravitreal anti-VEGF injection
47 Effect of Adjunctive Intravitreal Bevacizumab Before Panretinal Photocoagulation in Macular Thickness and Retinal Nerve Fiber Layer Thickness Completed NCT01504724 Phase 4 bevacizumab
48 A Randomized, Control, Parallel, Open Label, Multi-centre Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol in Combination on Patients With Diabetic Nephropathy Completed NCT01252056 Phase 4 Probucol;Probucol and Cilostazol
49 A Prospective, Multi-center, Randomized, Open-label, Parallel-arm Controlled Study of Treating Type 2 Diabetic Nephropathy (Stage II-IV) With Alfacalcidol and Irbesartan Completed NCT03147677 Phase 4 Alfacalcidol;Irbesartan
50 Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy With New Dense Vitreous Hemorrhage After Full Panretinal Photocoagulation Completed NCT01724385 Phase 4 intravitreal injection of bevacizumab

Search NIH Clinical Center for Microvascular Complications of Diabetes 5

Inferred drug relations via UMLS 71 / NDF-RT 50 :


benazepril
Benazepril hydrochloride
candesartan
candesartan cilexetil
Captopril
Enalapril
Enalapril Maleate
Enalaprilat
eprosartan
Eprosartan mesylate
Fosinopril
Fosinopril Sodium
irbesartan
Lisinopril
Losartan
Losartan Potassium
moexipril
Moexipril hydrochloride
olmesartan
Olmesartan medoxomil
Perindopril
Perindopril arginine
Perindopril Erbumine
quinapril
Quinapril hydrochloride
Ramipril
telmisartan
trandolapril
valsartan

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Microvascular Complications of Diabetes 5 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Microvascular Complications of Diabetes 5:
Bone marrow-derived hematopoietic stem cells for retinopathy
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Microvascular Complications of Diabetes 5:
Bone marrow-derived hematopoietic stem cells (family) PMIDs: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors PMIDs: 22247454
Bone marrow-derived mononuclear cells (family) PMIDs: 21225138 23000646 19347139 23049424

Cochrane evidence based reviews: diabetic retinopathy

Sources

Genetic Tests for Microvascular Complications of Diabetes 5

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Genetic tests related to Microvascular Complications of Diabetes 5:

# Genetic test Affiliating Genes
1 Diabetic Retinopathy 29
2 Microvascular Complications of Diabetes 5 29 PON1
Sources

Anatomical Context for Microvascular Complications of Diabetes 5

About this section

MalaCards organs/tissues related to Microvascular Complications of Diabetes 5:

40
Eye, Endothelial, Retina, Kidney, Testes, Bone, Pituitary
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Microvascular Complications of Diabetes 5:
# Tissue Anatomical CompartmentCell Relevance
1 Eye Outer Nuclear Layer Mature L Cone Cells Affected by disease, potential therapeutic candidate
2 Eye Outer Nuclear Layer Mature M Cone Cells Affected by disease, potential therapeutic candidate
3 Eye Inner Nuclear Layer Mature Muller Glia Cells Affected by disease
4 Eye Outer Nuclear Layer Mature Rod Cells Affected by disease, potential therapeutic candidate
5 Eye Outer Nuclear Layer Mature S Cone Cells Affected by disease, potential therapeutic candidate
Sources

Publications for Microvascular Complications of Diabetes 5

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Articles related to Microvascular Complications of Diabetes 5:

(show top 50) (show all 22409)
# Title Authors PMID Year
1
Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes. 54 61 56 6
11918623 2002
2
A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM. 54 61 6 56
9661650 1998
3
Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. 6 56
11335891 2001
4
Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families. 6
11889198 2002
5
LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects. 6
11788650 2002
6
Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes. 6
9011577 1997
7
Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes. 61 54
20225131 2010
8
Sorafenib protects human optic nerve head astrocytes from light-induced overexpression of vascular endothelial growth factor, platelet-derived growth factor, and placenta growth factor. 61 54
20166888 2010
9
Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy. 61 54
19216096 2010
10
Expression of stromal cell-derived factor-1 in diabetic retinopathy. 61 54
20497701 2010
11
Plasma and aqueous humor angiotensin-converting enzyme levels in patients with diabetic retinopathy. 61 54
20373882 2010
12
Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia. 54 61
19238311 2010
13
Diabetic retinopathy: An update on treatment. 61 54
20193825 2010
14
Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. 61 54
20088710 2010
15
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. 54 61
20008515 2010
16
Protein kinase C beta (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and diabetic retinopathy in a south Indian cohort. 54 61
20141354 2010
17
Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. 54 61
20142713 2010
18
Masked hypertension, nocturnal blood pressure and retinopathy in normotensive patients with type 1 diabetes. 54 61
19926157 2010
19
Sustained regression of florid diabetic retinopathy in a patient with Donohue syndrome (leprechaunism). 61 54
19882513 2010
20
Vascular endothelial growth factor-A: a multifunctional molecular player in diabetic retinopathy. 54 61
19646547 2009
21
Common sequence variation in the VEGFA gene predicts risk of diabetic retinopathy. 61 54
19553626 2009
22
The anti-angiogenic isoforms of VEGF in health and disease. 61 54
19909248 2009
23
Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes. 54 61
19752172 2009
24
Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina. 61 54
19709741 2009
25
Effects of trace elements on albumin and lipoprotein glycation in diabetic retinopathy. 54 61
19838431 2009
26
Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy. 54 61
19628492 2009
27
A systematic meta-analysis of genetic association studies for diabetic retinopathy. 54 61
19587357 2009
28
Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness. 61 54
19784389 2009
29
Similar progression of diabetic retinopathy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: a long-term, randomised, open-label study. 61 54
19526210 2009
30
Specific medical intervention for diabetic retinopathy. 54 61
19380207 2009
31
Differences in retinal neovascular tissue and vitreous humour in patients with type 1 and type 2 diabetes. 54 61
19304585 2009
32
Diabetic retinopathy in permanent neonatal diabetes due to Kir6.2 gene mutations: the results of a minimum 2-year follow-up after the transfer from insulin to sulphonylurea. 61 54
19538247 2009
33
Diabetic retinopathy, PAI-1 4G/5G and -844G/A polymorphisms, and changes in circulating PAI-1 levels in Tunisian type 2 diabetes patients. 61 54
19419896 2009
34
Systemic administration of HMG-CoA reductase inhibitor protects the blood-retinal barrier and ameliorates retinal inflammation in type 2 diabetes. 54 61
19254713 2009
35
Production of scFv antibody fragments from a hybridoma with functional activity against human vascular endothelial growth factor. 54 61
19445630 2009
36
Treating diabetic retinopathy by inhibiting growth factor pathways. 54 61
19337953 2009
37
Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. 61 54
19262488 2009
38
Single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 are markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes. 54 61
19263526 2009
39
Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes. 54 61
19365032 2009
40
[Role of vascular endothelial growth factor in the pathogenesis of diabetic retinopathy]. 61 54
19517837 2009
41
Low plasma basic fibroblast growth factor is associated with laser photocoagulation treatment in adult type 2 diabetes mellitus from the Veterans Affairs Diabetes Trial. 54 61
19217457 2009
42
Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2. 54 61
18974200 2009
43
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues. 61 54
19232015 2009
44
Impact of variants in the VEGF gene on progression of proliferative diabetic retinopathy. 54 61
18709380 2009
45
Analysis of three pigment epithelium-derived factor gene polymorphisms in patients with exudative age-related macular degeneration. 54 61
19223990 2009
46
[Proliferative diabetic retinopathy inauguring gestational diabetes]. 54 61
18514611 2008
47
Regulation of pigment epithelium-derived factor production and release by retinal glial (Müller) cells under hypoxia. 54 61
18676622 2008
48
Vasoinhibins: novel inhibitors of ocular angiogenesis. 61 54
18544641 2008
49
Is blockade of vascular endothelial growth factor beneficial for all types of diabetic retinopathy? 61 54
18607560 2008
50
Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. 61 54
18791689 2008
Sources

Variations for Microvascular Complications of Diabetes 5

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ClinVar genetic disease variations for Microvascular Complications of Diabetes 5:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PON1 NM_000446.7(PON1):c.163T>A (p.Leu55Met)SNV risk factor 13736 rs854560 7:94946084-94946084 7:95316772-95316772
Sources

Expression for Microvascular Complications of Diabetes 5

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Search GEO for disease gene expression data for Microvascular Complications of Diabetes 5.
Sources

Pathways for Microvascular Complications of Diabetes 5

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Pathways related to Microvascular Complications of Diabetes 5 according to KEGG:

36
# Name Kegg Source Accession
1 AGE-RAGE signaling pathway in diabetic complications hsa04933
2 HIF-1 signaling pathway hsa04066
3 Renin-angiotensin system hsa04614

Pathways related to Microvascular Complications of Diabetes 5 according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.83 VEGFA TEK PRKCB PGF KDR IGF1
2
GPCR Pathway 63
Show member pathways
 13.72 VEGFA TEK PRKCB PGF NOS3 KDR
3
Activation of cAMP-Dependent PKA 63
Show member pathways
 13.56 TEK PRKCB PGF NOS3 KDR IGF1
4
TGF-Beta Pathway 63
Show member pathways
 13.55 VEGFA TEK PGF KDR INS IGF1
5
Akt Signaling 63
Show member pathways
 13.42 TEK PRKCB PGF NOS3 KDR IGF1
6
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.34 VEGFA TEK SERPINE1 PRKCB NOS3 IGF1
7
CREB Pathway 63
Show member pathways
 13.33 TEK PRKCB PGF KDR IGF1 FLT1
8
PAK Pathway 63
Show member pathways
 13.32 TEK PRKCB PGF KDR IGF1 FLT1
9
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.24 VEGFA TEK PRKCB PGF NOS3 KDR
10
Phospholipase-C Pathway 63
Show member pathways
 13.07 PRKCB PGF KDR IGF1 FLT1 FGF2
11
p70S6K Signaling 63
Show member pathways
 13.01 PRKCB PGF KDR INS IGF1 FLT1
12
Focal Adhesion 36 1
Show member pathways
 12.92 VEGFA PRKCB PGF KDR IGF1 FLT1
13
PI3K-Akt signaling pathway 36
Show member pathways
 12.86 VEGFA TEK PGF NOS3 KDR INS
14
Pathways in cancer 36
12.84 VEGFA PRKCB PGF IGF1 FGF2
15
NF-KappaB Family Pathway 63
Show member pathways
 12.73 PRKCB PGF KDR IGF1 FLT1 FGF2
16
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling 64
Show member pathways
 12.68 VEGFA PRKCB NOS3 KDR ICAM1
17
ErbB signaling pathway 36 1
Show member pathways
 12.64 VEGFA PRKCB KDR IGF1 FGF2
18
MAPK signaling pathway 36 1
12.62 VEGFA TEK PRKCB PGF KDR INS
19
mTOR signaling pathway (KEGG) 36
Show member pathways
 12.53 PRKCB KDR INS IGF1 FLT1
20
VEGF Signaling 66
Show member pathways
 12.5 VEGFA PRKCB NOS3 KDR FLT1 FGF2
21
Ras signaling pathway 36
Show member pathways
 12.5 VEGFA TEK PRKCB PGF KDR INS
22
Apoptosis Pathway 70
Show member pathways
 12.44 PRKCB NOS3 KDR FLT1
23
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.43 TEK PGF KDR IGF1 FLT1 FGF2
24
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways