MCID: MCR120
MIFTS: 37

Microvascular Complications of Diabetes 7

Categories: Genetic diseases, Nephrological diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Microvascular Complications of Diabetes 7

MalaCards integrated aliases for Microvascular Complications of Diabetes 7:

Name: Microvascular Complications of Diabetes 7 57 75 29 13 6
Diabetic Nephropathy 75 73
Mvcd7 57 75
Microvascular Complications of Diabetes, Susceptibility to, 7 57
Nonproliferative Retinopathy, Diabetic, Susceptibility to 57
Proliferative Retinopathy, Diabetic, Susceptibility to 57
Microvascular Complications of Diabetes, Type 7 40
Nephropathy, Diabetic, Susceptibility to 57
Nonproliferative Retinopathy, Diabetic 57
Diabetic Non-Proliferative Retinopathy 75
Proliferative Retinopathy, Diabetic 57
Proliferative Diabetic Retinopathy 73
Diabetic Proliferative Retinopathy 75
Nephropathy, Diabetic 57

Classifications:



External Ids:

OMIM 57 612635
MeSH 44 D048909
UMLS 73 C0011881

Summaries for Microvascular Complications of Diabetes 7

UniProtKB/Swiss-Prot : 75 Microvascular complications of diabetes 7: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

MalaCards based summary : Microvascular Complications of Diabetes 7, also known as diabetic nephropathy, is related to atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease and microvascular complications of diabetes 3. An important gene associated with Microvascular Complications of Diabetes 7 is HFE (Homeostatic Iron Regulator). Affiliated tissues include endothelial, kidney and monocytes.

Description from OMIM: 612635

Related Diseases for Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Microvascular Complications of Diabetes 7:



Diseases related to Microvascular Complications of Diabetes 7

Symptoms & Phenotypes for Microvascular Complications of Diabetes 7

Clinical features from OMIM:

612635

Drugs & Therapeutics for Microvascular Complications of Diabetes 7

Genetic Tests for Microvascular Complications of Diabetes 7

Genetic tests related to Microvascular Complications of Diabetes 7:

# Genetic test Affiliating Genes
1 Microvascular Complications of Diabetes 7 29 HFE

Anatomical Context for Microvascular Complications of Diabetes 7

MalaCards organs/tissues related to Microvascular Complications of Diabetes 7:

41
Endothelial, Kidney, Monocytes, Bone, Heart, Liver, Testes

Publications for Microvascular Complications of Diabetes 7

Articles related to Microvascular Complications of Diabetes 7:

(show top 50) (show all 1537)
# Title Authors Year
1
Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy. ( 28864059 )
2018
2
Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. ( 29966984 )
2018
3
FGF23<sup>C-tail</sup> improves diabetic nephropathy by attenuating renal fibrosis and inflammation. ( 29843712 )
2018
4
Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. ( 29845659 )
2018
5
MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. ( 29932921 )
2018
6
Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy. ( 29334763 )
2018
7
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study). ( 29372470 )
2018
8
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-I_B signaling pathways in diabetic nephropathy. ( 29795979 )
2018
9
The association between interleukin-19 concentration and diabetic nephropathy. ( 28201997 )
2017
10
Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. ( 28934365 )
2017
11
Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. ( 28667184 )
2017
12
Serum obestatin and omentin levels in patients with diabetic nephropathy. ( 28091434 )
2017
13
MicroRNA-27a promotes podocyte injury via PPARI^-mediated I^-catenin activation in diabetic nephropathy. ( 28277542 )
2017
14
ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy. ( 28325697 )
2017
15
Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis. ( 28851298 )
2017
16
Clinical Implication of Cystatin C and I^2-Microglobulin in Early Detection of Diabetic Nephropathy. ( 28182344 )
2017
17
Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation. ( 28726774 )
2017
18
NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy. ( 28137583 )
2017
19
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice. ( 28767064 )
2017
20
Collagenofibrotic (Collagen Type III) glomerulopathy in association with diabetic nephropathy. ( 28748894 )
2017
21
Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients. ( 28326331 )
2017
22
Maximum home blood pressure is a useful indicator of diabetic nephropathy in patients with type 2 diabetes mellitus: KAMOGAWA-HBP study. ( 28819987 )
2017
23
NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients. ( 28631886 )
2017
24
Cardiac troponin T elevation at dialysis initiation is associated with all-cause and cardiovascular mortality on dialysis in patients without diabetic nephropathy. ( 27178276 )
2017
25
AR C-106T gene polymorphism and diabetic nephropathy in the Eastern Asians with T2DM: A meta-analysis including 2120 subjects. ( 28651212 )
2017
26
Association of Pentraxin 3 Gene Polymorphisms with Susceptibility to Diabetic Nephropathy. ( 28119515 )
2017
27
Lysine 63 ubiquitination is involved in the progression of tubular damage in diabetic nephropathy. ( 27881486 )
2017
28
Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy. ( 28356293 )
2017
29
Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy. ( 28668213 )
2017
30
High levels of circulating TNFR1 increase the risk of all-cause mortality and progression of renal disease in type 2 diabetic nephropathy. ( 27003829 )
2017
31
RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction. ( 28704853 )
2017
32
Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model. ( 28805484 )
2017
33
Exocytosis-Mediated Urinary Full-Length Megalin Excretion Is Linked With the Pathogenesis of Diabetic Nephropathy. ( 28289043 )
2017
34
Urinary heme oxygenase-1 as a potential biomarker for early diabetic nephropathy. ( 26733347 )
2017
35
NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus. ( 28620620 )
2017
36
Function of NLRP3 in the Pathogenesis and Development of Diabetic Nephropathy. ( 28798291 )
2017
37
The <i>CNDP1</i> (CTG)<sub>5</sub> Polymorphism Is Associated with Biopsy-Proven Diabetic Nephropathy, Time on Hemodialysis, and Diabetes Duration. ( 28553654 )
2017
38
Paraoxonase 1 polymorphisms (L55M and Q192R) as a genetic marker of diabetic nephropathy in youth with type 1 diabetes. ( 26884296 )
2017
39
EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress. ( 28427241 )
2017
40
ApoM/HDL-C and apoM/apoA-I ratios are indicators of diabetic nephropathy in healthy controls and type 2 diabetes mellitus. ( 28073663 )
2017
41
Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. ( 28246612 )
2017
42
The Impact of Peroxisome Proliferator-Activated Receptor Gamma and Its Interaction with Abdominal Obesity on Diabetic Nephropathy in Chinese Han. ( 28013303 )
2017
43
Resistin-Like Molecule Beta (RELM-I^) Regulates Proliferation of Human Diabetic Nephropathy Mesangial Cells via Mitogen-Activated Protein Kinases (MAPK) Signaling Pathway. ( 28801998 )
2017
44
Multi-glycoside of Tripterygium wilfordii Hook.A f. attenuates glomerulosclerosis in a rat model of diabetic nephropathy by exerting anti-microinflammatory effects without affecting hyperglycemia. ( 28731135 )
2017
45
Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population. ( 28246355 )
2017
46
Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes - preliminary results of a family-based study. ( 28255976 )
2017
47
Association of irisin and FNDC5 rs16835198 G&amp;gt;T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study. ( 28479383 )
2017
48
Effects of Bone Marrow Mesenchymal Stem Cells on Plasminogen Activator Inhibitor-1 and Renal Fibrosis in Rats with Diabetic Nephropathy. ( 27018336 )
2016
49
Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy. ( 25814621 )
2016
50
Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes. ( 27083286 )
2016

Variations for Microvascular Complications of Diabetes 7

ClinVar genetic disease variations for Microvascular Complications of Diabetes 7:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HFE NM_000410.3(HFE): c.187C> G (p.His63Asp) single nucleotide variant Pathogenic,risk factor rs1799945 GRCh37 Chromosome 6, 26091179: 26091179
2 HFE NM_000410.3(HFE): c.187C> G (p.His63Asp) single nucleotide variant Pathogenic,risk factor rs1799945 GRCh38 Chromosome 6, 26090951: 26090951

Expression for Microvascular Complications of Diabetes 7

Search GEO for disease gene expression data for Microvascular Complications of Diabetes 7.

Pathways for Microvascular Complications of Diabetes 7

GO Terms for Microvascular Complications of Diabetes 7

Sources for Microvascular Complications of Diabetes 7

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