MCID: MDD003
MIFTS: 36

Middle Cerebral Artery Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Middle Cerebral Artery Infarction

MalaCards integrated aliases for Middle Cerebral Artery Infarction:

Name: Middle Cerebral Artery Infarction 38 12 15
Infarction, Middle Cerebral Artery 44 73
Infarction Middle Cerebral Artery 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3525
MeSH 44 D020244
UMLS 73 C0740392

Summaries for Middle Cerebral Artery Infarction

MalaCards based summary : Middle Cerebral Artery Infarction, also known as infarction, middle cerebral artery, is related to brain edema and ependymoma. An important gene associated with Middle Cerebral Artery Infarction is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Piracetam and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and heart.

Related Diseases for Middle Cerebral Artery Infarction

Diseases related to Middle Cerebral Artery Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 brain edema 10.3
2 ependymoma 10.2 ENO2 S100B
3 neuroma 10.2 ENO2 S100B
4 intracranial cysts 10.2 ENO2 S100B
5 bednar tumor 10.2 ENO2 S100B
6 epithelioid malignant peripheral nerve sheath tumor 10.1 ENO2 S100B
7 ossifying fibromyxoid tumor 10.1 ENO2 S100B
8 head injury 10.1 ENO2 S100B
9 pineocytoma 10.1 ENO2 S100B
10 granular cell tumor 10.1 ENO2 S100B
11 spondylosis 10.1 ENO2 S100B
12 subependymal giant cell astrocytoma 10.1 ENO2 S100B
13 cerebral primitive neuroectodermal tumor 10.1 ENO2 S100B
14 traumatic brain injury 10.1 ENO2 S100B
15 brain injury 10.1 ENO2 S100B
16 olfactory neuroblastoma 10.1 ENO2 S100B
17 hypoganglionosis 10.1 NCAM1 S100B
18 myxopapillary ependymoma 10.1 NCAM1 S100B
19 supratentorial primitive neuroectodermal tumor 10.1 NCAM1 S100B
20 hemangioblastoma 10.1 ENO2 S100B
21 multiple mucosal neuroma 10.1 ENO2 NCAM1
22 lung meningioma 10.1 ENO2 NCAM1
23 perineurioma 10.1 NCAM1 S100B
24 acute mountain sickness 10.1 ENO2 S100B
25 gallbladder small cell carcinoma 10.1 ENO2 NCAM1
26 small cell carcinoma 10.1 ENO2 NCAM1
27 cutaneous ganglioneuroma 10.1 ENO2 NCAM1
28 ganglioneuroma 10.1 ENO2 NCAM1
29 extraosseous ewing's sarcoma 10.1 ENO2 S100B
30 extrahepatic bile duct adenocarcinoma 10.1 ENO2 NCAM1
31 choriocarcinoma of ovary 10.1 ENO2 NCAM1
32 orbital cancer 10.1 ENO2 NCAM1
33 optic nerve glioma 10.1 ENO2 S100B
34 endometrial small cell carcinoma 10.1 ENO2 NCAM1
35 pilomatrixoma 10.1 ENO2 S100B
36 angiomyoma 10.1 ENO2 NCAM1
37 gastric small cell carcinoma 10.1 ENO2 NCAM1
38 subependymoma 10.1 ENO2 NCAM1
39 ganglioglioma 10.1 ENO2 S100B
40 gastric squamous cell carcinoma 10.1 ENO2 NCAM1
41 neurilemmoma 10.1 ENO2 S100B
42 rete testis neoplasm 10.1 ENO2 NCAM1
43 clear cell sarcoma 10.1 ENO2 S100B
44 cervix small cell carcinoma 10.1 ENO2 NCAM1
45 cranial nerve malignant neoplasm 10.1 ENO2 NCAM1
46 large cell neuroendocrine carcinoma 10.1 ENO2 NCAM1
47 mixed ductal-endocrine carcinoma 10.1 ENO2 NCAM1
48 microglandular adenosis 10.1 KRT18 S100B
49 ileum cancer 10.1 ENO2 NCAM1
50 adrenal rest tumor 10.1 ENO2 NCAM1

Graphical network of the top 20 diseases related to Middle Cerebral Artery Infarction:



Diseases related to Middle Cerebral Artery Infarction

Symptoms & Phenotypes for Middle Cerebral Artery Infarction

Drugs & Therapeutics for Middle Cerebral Artery Infarction

Drugs for Middle Cerebral Artery Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Piracetam Approved, Investigational Phase 4 7491-74-9
2 Pharmaceutical Solutions Phase 4
3
Mannitol Approved, Investigational Phase 3,Not Applicable 69-65-8 453 6251
4 Tissue Plasminogen Activator Phase 2, Phase 3
5 Epoetin alfa Phase 2, Phase 3 113427-24-0
6 Hematinics Phase 2, Phase 3
7 Fibrinolytic Agents Phase 3
8
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
9
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
10 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2,Not Applicable
11 Antimetabolites Phase 1, Phase 2
12 Hypolipidemic Agents Phase 1, Phase 2
13 Anticholesteremic Agents Phase 1, Phase 2
14 Calcium, Dietary Phase 1, Phase 2
15 Lipid Regulating Agents Phase 1, Phase 2
16 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
18 glucocorticoids Phase 2
19 Antineoplastic Agents, Hormonal Phase 2
20 Hormone Antagonists Phase 2
21 Antimitotic Agents Phase 2
22 Hormones Phase 2
23 Anti-Inflammatory Agents Phase 2
24 Androgens Phase 2
25
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
26
Lidocaine Approved, Vet_approved ,Not Applicable 137-58-6 3676
27
Midazolam Approved, Illicit 59467-70-8 4192
28
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
29
Rocuronium Approved 119302-91-9, 143558-00-3 441290
30
Sevoflurane Approved, Vet_approved 28523-86-6 5206
31
Glycerol Approved, Investigational Not Applicable 56-81-5 753
32 Analgesics, Opioid
33 Central Nervous System Depressants
34 Peripheral Nervous System Agents
35 Anti-Arrhythmia Agents
36 Sodium Channel Blockers
37 Anesthetics ,Not Applicable
38 Anesthetics, Inhalation
39 Anesthetics, Local
40 Platelet Aggregation Inhibitors
41 Anesthetics, General
42 Diuretics, Potassium Sparing

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
2 Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke Completed NCT00604630 Phase 2, Phase 3 recombinant human erythropoietin alfa;0.9% NaCl
3 Endovascular Therapy for Acute Ischemic Stroke Trial Completed NCT02350283 Phase 3
4 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
5 Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI): A Single Center Randomized Controlled Clinical Trial Terminated NCT02002234 Phase 3
6 Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke Terminated NCT01778335 Phase 3
7 Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct Unknown status NCT01461720 Phase 2
8 Application of Contrast Enhance Ultrasound to Evaluate Hemodynamics Change in MCA With Moderate to Severe Stenosis Unknown status NCT01617538 Phase 1, Phase 2 atorvastatin
9 Stem Cell Therapy For Acute Ischemic Stroke Patients Completed NCT02425670 Phase 2
10 Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients Completed NCT00950521 Phase 2 convention therapy
11 Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Completed NCT00761982 Phase 1, Phase 2
12 Pilot Efficacy Study of PI-88 With Docetaxel to Treat Prostate Cancer Completed NCT00268593 Phase 2 PI-88;docetaxel;prednisone
13 The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018) Terminated NCT00401310 Phase 2 Comparator: Placebo;Comparator: MK0724
14 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke Terminated NCT01310114 Phase 2 Placebo
15 A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke Terminated NCT02928393 Phase 2 Basmisanil;Placebo
16 Intraarterial Stem Cells in Subacute Ischemic Stroke Completed NCT03080571 Phase 1
17 Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery Unknown status NCT00867581
18 General Anesthesia for Endovascular Thrombectomy; A Pilot Study. Unknown status NCT02639806 Sevoflurane;Lidocaine
19 Gait Training for Persons With Stroke Completed NCT00612300 Early Phase 1
20 Dual-Task Training With Different Priority Instructional Sets on the Gait Parameters in Patients With Chronic Stroke Completed NCT03752788 Not Applicable
21 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
22 ERic Acute StrokE Recanalization (ERASER) Completed NCT02534701
23 Intracranial Pressure After Decompressive Craniectomy Completed NCT03364634
24 tDCS in Acute Stroke Patients Recruiting NCT02806856 Not Applicable
25 Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies Active, not recruiting NCT00467103
26 Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy. Not yet recruiting NCT03221959
27 aICP Measurement in Patients With Cerebral Artery Infarction / aICP MCA Infarction Not yet recruiting NCT03641963 Not Applicable
28 Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery Terminated NCT02609256 Not Applicable

Search NIH Clinical Center for Middle Cerebral Artery Infarction

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Middle Cerebral Artery Infarction cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Middle Cerebral Artery Infarction:
Neuroncell�, bone marrow-derived mesenchymal stem cells for middle cerebral artery infarct
Embryonic/Adult Cultured Cells Related to Middle Cerebral Artery Infarction:
Bone marrow-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: infarction, middle cerebral artery

Genetic Tests for Middle Cerebral Artery Infarction

Anatomical Context for Middle Cerebral Artery Infarction

MalaCards organs/tissues related to Middle Cerebral Artery Infarction:

41
Bone, Brain, Heart, Bone Marrow, Pituitary, Lung, Ovary

Publications for Middle Cerebral Artery Infarction

Articles related to Middle Cerebral Artery Infarction:

(show top 50) (show all 216)
# Title Authors Year
1
Decompressive hemicraniectomy for malignant middle cerebral artery infarction including patients with additional involvement of the anterior and/or posterior cerebral artery territory-outcome analysis and definition of prognostic factors. ( 28965156 )
2018
2
High serum levels of caspase-cleaved cytokeratin-18 are associated with malignant middle cerebral artery infarction patient mortality. ( 29573748 )
2018
3
Physician awareness of decompressive hemicraniectomy for malignant middle cerebral artery infarction in Saudi Arabia and the Gulf countries. ( 29664455 )
2018
4
Early Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction in Asian Patients: A Single-Center Study. ( 29317364 )
2018
5
Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction. ( 29848129 )
2018
6
Age-Dependent Attitudes of Ischemic Patients Toward Disability After Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 29458183 )
2018
7
Decompressive Craniotomy for Malignant Middle Cerebral Artery Infarction: Optimal Timing and Literature Review. ( 29653270 )
2018
8
Intracranial Pressure Soon After Hemicraniectomy in Malignant Middle Cerebral Artery Infarction. ( 28523953 )
2018
9
NIHSS sub-item scores predict collateral flow in acute middle cerebral artery infarction. ( 29991309 )
2018
10
A Systematic Review and Meta-Analysis of the Effectiveness of Surgical Decompression in Treating Patients with Malignant Middle Cerebral Artery Infarction. ( 30193963 )
2018
11
Selective Brain Hypothermia Augmenting Neuroprotective Effects of Decompressive Craniectomy for Permanent Middle Cerebral Artery Infarction in a Rat Model. ( 30261392 )
2018
12
A cost-utility analysis of decompressive hemicraniectomy versus medical treatment in the management of space-occupying brain oedema post middle cerebral artery infarction. ( 30266037 )
2018
13
Decompressive hemicraniectomy after malignant middle cerebral artery infarction: does hospital of origin matter? ( 30288900 )
2018
14
Stereotactic Aspiration of Necrotic Brain Tissue for treating Malignant Middle Cerebral Artery Infarction: A Report of 13 consecutive Cases. ( 30404052 )
2018
15
Cerebral Venous Drainage in Patients With Space-Occupying Middle Cerebral Artery Infarction: Effects on Functional Outcome After Hemicraniectomy. ( 30459703 )
2018
16
Decompressive hemicraniectomy in the treatment of malignant middle cerebral artery infarction: a meta-analysis. ( 30500591 )
2018
17
Malignant middle cerebral artery infarction. ( 28438757 )
2017
18
The Protective Effect of Middle Cerebral Artery Calcification on Symptomatic Middle Cerebral Artery Infarction. ( 28939676 )
2017
19
Pharyngolaryngeal Sensory Deficits in Patients with Middle Cerebral Artery Infarction: Lateralization and Relation to Overall Dysphagia Severity. ( 28972945 )
2017
20
National Survey of Neurosurgeons and Stroke Physicians on Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 28235642 )
2017
21
Protein microarray analysis identifies key cytokines associated with malignant middle cerebral artery infarction. ( 28828208 )
2017
22
Clinical and Radiological Predictors of Malignant Middle Cerebral Artery Infarction Development and Outcomes. ( 28736129 )
2017
23
Decompressive hemicraniectomy for malignant middle cerebral artery infarction. Experience from the Western Province of Saudi Arabia. ( 28678213 )
2017
24
Massive Middle Cerebral Artery Infarction After Surgically Assisted Rapid Palatal Expansion: A Case Report. ( 28438597 )
2017
25
Decompressive craniectomy for the treatment of malignant middle cerebral artery infarction. ( 28604106 )
2017
26
Musical, visual and cognitive deficits after middle cerebral artery infarction. ( 29260010 )
2017
27
Predictors of early in-hospital death after decompressive craniectomy in swollen middle cerebral artery infarction. ( 27942881 )
2017
28
Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach. ( 29202815 )
2017
29
Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction. ( 26666449 )
2016
30
Decompressive craniectomy for malignant middle cerebral artery infarction in a 16-year old boy: a case report. ( 27998316 )
2016
31
Malignant Middle Cerebral Artery Infarction Secondary to Traumatic Bilateral Internal Carotid Artery Dissection. A Case Report. ( 29967852 )
2016
32
De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited. ( 27091344 )
2016
33
Malignant middle cerebral artery infarction: An unusual but severe neurovascular condition. ( 27147151 )
2016
34
Impact of timing of cranioplasty on hydrocephalus after decompressive hemicraniectomy in malignant middle cerebral artery infarction. ( 28012353 )
2016
35
Identification of cytokines for early prediction of malignant middle cerebral artery infarction. ( 26981614 )
2016
36
Analysis of the Outcome and Prognostic Factors of Decompressive Craniectomy between Young and Elderly Patients for Acute Middle Cerebral Artery Infarction. ( 27847759 )
2016
37
Reduction of Midline Shift Following Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 27733025 )
2016
38
Neurologic Functional Outcomes of Decompressive Hemicraniectomy Versus Conventional Treatment for Malignant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis. ( 28024976 )
2016
39
Predictive factors for decompressive hemicraniectomy in malignant middle cerebral artery infarction. ( 26923797 )
2016
40
10-Year Institutional Retrospective Case Series of Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction (mMCAI). ( 27639522 )
2016
41
Clinical course, prognostic factors, and long-term outcomes of malignant middle cerebral artery infarction patients in the modern era. ( 27147150 )
2016
42
Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction: A Case-Control Study. ( 27443695 )
2016
43
Crossed cerebellar diaschisis in patients with acute middle cerebral artery infarction: Occurrence and perfusion characteristics. ( 26661242 )
2016
44
Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Infarction: The 'Real World' Beyond Studies. ( 27379413 )
2016
45
Predicting Mortality in Patients With "Malignant" Middle Cerebral Artery Infarction Using Susceptibility-Weighted Magnetic Resonance Imaging: Preliminary Findings. ( 26937906 )
2016
46
Decompressive craniectomy in malignant middle cerebral artery infarction: To be, or not to be? ( 29443256 )
2016
47
Prediction of Malignant Middle Cerebral Artery Infarction in Elderly Patients. ( 27009609 )
2016
48
Decompressive craniectomy 116a88h after malignant middle cerebral artery infarction. ( 26892675 )
2016
49
Functional Outcomes of Decompressive Craniectomy in Patients with Malignant Middle Cerebral Artery Infarction and Their Association with Preoperative Thalamus Deformation: An Analysis of 12 Patients. ( 27477404 )
2016
50
Decompressive craniectomy for severe middle cerebral artery infarction: a meta-analysis of randomised controlled trials. ( 27968912 )
2016

Variations for Middle Cerebral Artery Infarction

Expression for Middle Cerebral Artery Infarction

Search GEO for disease gene expression data for Middle Cerebral Artery Infarction.

Pathways for Middle Cerebral Artery Infarction

Pathways related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 ENO2 NCAM1 S100B
2 10.85 NCAM1 S100B

GO Terms for Middle Cerebral Artery Infarction

Cellular components related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 CD40LG ENO2 PLAT S100B
2 cell surface GO:0009986 8.8 CD40LG NCAM1 PLAT

Biological processes related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 8.62 CD40LG KRT18

Sources for Middle Cerebral Artery Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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