MCID: MDD003
MIFTS: 37

Middle Cerebral Artery Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Middle Cerebral Artery Infarction

MalaCards integrated aliases for Middle Cerebral Artery Infarction:

Name: Middle Cerebral Artery Infarction 38 12 15
Infarction, Middle Cerebral Artery 44 73
Infarction Middle Cerebral Artery 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3525
MeSH 44 D020244
UMLS 73 C0740392

Summaries for Middle Cerebral Artery Infarction

MalaCards based summary : Middle Cerebral Artery Infarction, also known as infarction, middle cerebral artery, is related to cerebritis and intracranial cysts. An important gene associated with Middle Cerebral Artery Infarction is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways is HIF-1 signaling pathway. The drugs Piracetam and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotype is nervous system.

Related Diseases for Middle Cerebral Artery Infarction

Diseases related to Middle Cerebral Artery Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 cerebritis 11.0
2 intracranial cysts 10.4 ENO2 S100B
3 bednar tumor 10.4 ENO2 S100B
4 epithelioid malignant peripheral nerve sheath tumor 10.4 ENO2 S100B
5 ossifying fibromyxoid tumor 10.4 ENO2 S100B
6 head injury 10.4 ENO2 S100B
7 melanotic neuroectodermal tumor 10.4 ENO2 S100B
8 pineocytoma 10.4 ENO2 S100B
9 papillary ependymoma 10.4 ENO2 S100B
10 subependymal giant cell astrocytoma 10.4 ENO2 S100B
11 granular cell tumor 10.4 ENO2 S100B
12 meningeal melanocytoma 10.4 ENO2 S100B
13 spondylosis 10.4 ENO2 S100B
14 olfactory neuroblastoma 10.4 ENO2 S100B
15 cerebral primitive neuroectodermal tumor 10.4 ENO2 S100B
16 traumatic brain injury 10.4 ENO2 S100B
17 optic nerve glioma 10.3 ENO2 S100B
18 extraosseous ewing's sarcoma 10.3 ENO2 S100B
19 pilomatrixoma 10.3 ENO2 S100B
20 brain injury 10.3 ENO2 S100B
21 ganglioglioma 10.3 ENO2 S100B
22 neurilemmoma 10.3 ENO2 S100B
23 clear cell sarcoma 10.3 ENO2 S100B
24 ependymoma 10.3 ENO2 S100B
25 neuroma 10.3 ENO2 S100B
26 hemangioblastoma 10.2 ENO2 S100B
27 human immunodeficiency virus infectious disease 10.2 CD40LG S100B
28 leiomyosarcoma 10.2 ENO2 S100B
29 brain edema 10.1
30 gliosarcoma 10.1 ENO2 S100B
31 acute chest syndrome 10.1 CD40LG EDN1
32 cardiac arrest 10.0 ENO2 S100B
33 aging 10.0
34 sleep apnea 10.0 EDN1 S100B
35 hydrocephalus 9.9
36 ischemia 9.9
37 carotid artery dissection 9.9
38 glioblastoma 9.9
39 wallerian degeneration 9.9
40 creutzfeldt-jakob disease 9.9 ENO2 S100B
41 urinary system disease 9.8 CD40LG EDN1
42 dressler's syndrome 9.8 CD40LG PLAT
43 secondary progressive multiple sclerosis 9.8 CD40LG ENO2 S100B
44 stroke, ischemic 9.8
45 aphasia 9.8
46 amusia 9.8
47 hemiplegia 9.8
48 pituitary apoplexy 9.8
49 pure red-cell aplasia 9.8
50 transient cerebral ischemia 9.8

Graphical network of the top 20 diseases related to Middle Cerebral Artery Infarction:



Diseases related to Middle Cerebral Artery Infarction

Symptoms & Phenotypes for Middle Cerebral Artery Infarction

MGI Mouse Phenotypes related to Middle Cerebral Artery Infarction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 CD40LG EDN1 ENO2 PLAT PLEKHM1

Drugs & Therapeutics for Middle Cerebral Artery Infarction

Drugs for Middle Cerebral Artery Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Piracetam Approved, Investigational Phase 4 7491-74-9
2 Pharmaceutical Solutions Phase 4
3
Mannitol Approved, Investigational Phase 3,Not Applicable 69-65-8 453 6251
4 Epoetin alfa Phase 2, Phase 3 113427-24-0
5 Hematinics Phase 2, Phase 3
6 Tissue Plasminogen Activator Phase 2, Phase 3
7 Fibrinolytic Agents Phase 3
8
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
9
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
10 Anticholesteremic Agents Phase 1, Phase 2
11 Antimetabolites Phase 1, Phase 2
12 Atorvastatin Calcium Phase 1, Phase 2 134523-03-8
13 Calcium, Dietary Phase 1, Phase 2
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2,Not Applicable
15 Hypolipidemic Agents Phase 1, Phase 2
16 Lipid Regulating Agents Phase 1, Phase 2
17 Androgens Phase 2
18 Anti-Inflammatory Agents Phase 2
19 Antimitotic Agents Phase 2
20 Antineoplastic Agents, Hormonal Phase 2
21 glucocorticoids Phase 2
22 Hormone Antagonists Phase 2
23 Hormones Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
25
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
26
Lidocaine Approved, Vet_approved ,Not Applicable 137-58-6 3676
27
Midazolam Approved, Illicit 59467-70-8 4192
28
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
29
Rocuronium Approved 119302-91-9, 143558-00-3 441290
30
Sevoflurane Approved, Vet_approved 28523-86-6 5206
31
Glycerol Approved, Investigational Not Applicable 56-81-5 753
32 Anesthetics ,Not Applicable
33 Anesthetics, General
34 Anesthetics, Inhalation
35 Anesthetics, Local
36 Anti-Arrhythmia Agents
37 Central Nervous System Depressants
38 Diuretics, Potassium Sparing
39 Peripheral Nervous System Agents
40 Platelet Aggregation Inhibitors
41 Sodium Channel Blockers

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
2 Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke Completed NCT00604630 Phase 2, Phase 3 recombinant human erythropoietin alfa;0.9% NaCl
3 Endovascular Therapy for Acute Ischemic Stroke Trial Completed NCT02350283 Phase 3
4 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
5 Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI): A Single Center Randomized Controlled Clinical Trial Terminated NCT02002234 Phase 3
6 Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke Terminated NCT01778335 Phase 3
7 Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct Unknown status NCT01461720 Phase 2
8 Application of Contrast Enhance Ultrasound to Evaluate Hemodynamics Change in MCA With Moderate to Severe Stenosis Unknown status NCT01617538 Phase 1, Phase 2 atorvastatin
9 Stem Cell Therapy For Acute Ischemic Stroke Patients Completed NCT02425670 Phase 2
10 Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients Completed NCT00950521 Phase 2 convention therapy
11 Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Completed NCT00761982 Phase 1, Phase 2
12 Pilot Efficacy Study of PI-88 With Docetaxel to Treat Prostate Cancer Completed NCT00268593 Phase 2 PI-88;docetaxel;prednisone
13 The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018) Terminated NCT00401310 Phase 2 Comparator: Placebo;Comparator: MK0724
14 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke Terminated NCT01310114 Phase 2 Placebo
15 A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke Terminated NCT02928393 Phase 2 Basmisanil;Placebo
16 Intraarterial Stem Cells in Subacute Ischemic Stroke Completed NCT03080571 Phase 1
17 Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery Unknown status NCT00867581
18 General Anesthesia for Endovascular Thrombectomy; A Pilot Study. Unknown status NCT02639806 Sevoflurane;Lidocaine
19 Gait Training for Persons With Stroke Completed NCT00612300 Early Phase 1
20 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
21 ERic Acute StrokE Recanalization (ERASER) Completed NCT02534701
22 Intracranial Pressure After Decompressive Craniectomy Completed NCT03364634
23 tDCS in Acute Stroke Patients Recruiting NCT02806856 Not Applicable
24 Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies Active, not recruiting NCT00467103
25 Non-invasive Absolute Intracranial Pressure Measurement in Patients With Malignant Middle Cerebral Artery Infarction for Determination of Timing to Descompressive Craniectomy. Not yet recruiting NCT03221959
26 Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery Terminated NCT02609256 Not Applicable

Search NIH Clinical Center for Middle Cerebral Artery Infarction

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Middle Cerebral Artery Infarction cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Middle Cerebral Artery Infarction:
Neuroncell
Embryonic/Adult Cultured Cells Related to Middle Cerebral Artery Infarction:
Bone marrow-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: infarction, middle cerebral artery

Genetic Tests for Middle Cerebral Artery Infarction

Anatomical Context for Middle Cerebral Artery Infarction

MalaCards organs/tissues related to Middle Cerebral Artery Infarction:

41
Bone, Brain, Bone Marrow, Prostate, Cortex, Pituitary, Thalamus

Publications for Middle Cerebral Artery Infarction

Articles related to Middle Cerebral Artery Infarction:

(show top 50) (show all 209)
# Title Authors Year
1
Decompressive hemicraniectomy for malignant middle cerebral artery infarction including patients with additional involvement of the anterior and/or posterior cerebral artery territory-outcome analysis and definition of prognostic factors. ( 28965156 )
2018
2
High serum levels of caspase-cleaved cytokeratin-18 are associated with malignant middle cerebral artery infarction patient mortality. ( 29573748 )
2018
3
Physician awareness of decompressive hemicraniectomy for malignant middle cerebral artery infarction in Saudi Arabia and the Gulf countries. ( 29664455 )
2018
4
Early Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction in Asian Patients: A Single-Center Study. ( 29317364 )
2018
5
Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction. ( 29848129 )
2018
6
Age-Dependent Attitudes of Ischemic Patients Toward Disability After Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 29458183 )
2018
7
Decompressive Craniotomy for Malignant Middle Cerebral Artery Infarction: Optimal Timing and Literature Review. ( 29653270 )
2018
8
Malignant middle cerebral artery infarction. ( 28438757 )
2017
9
The Protective Effect of Middle Cerebral Artery Calcification on Symptomatic Middle Cerebral Artery Infarction. ( 28939676 )
2017
10
Pharyngolaryngeal Sensory Deficits in Patients with Middle Cerebral Artery Infarction: Lateralization and Relation to Overall Dysphagia Severity. ( 28972945 )
2017
11
National Survey of Neurosurgeons and Stroke Physicians on Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 28235642 )
2017
12
Protein microarray analysis identifies key cytokines associated with malignant middle cerebral artery infarction. ( 28828208 )
2017
13
Clinical and Radiological Predictors of Malignant Middle Cerebral Artery Infarction Development and Outcomes. ( 28736129 )
2017
14
Decompressive hemicraniectomy for malignant middle cerebral artery infarction. Experience from the Western Province of Saudi Arabia. ( 28678213 )
2017
15
Massive Middle Cerebral Artery Infarction After Surgically Assisted Rapid Palatal Expansion: A Case Report. ( 28438597 )
2017
16
Decompressive craniectomy for the treatment of malignant middle cerebral artery infarction. ( 28604106 )
2017
17
Musical, visual and cognitive deficits after middle cerebral artery infarction. ( 29260010 )
2017
18
Predictors of early in-hospital death after decompressive craniectomy in swollen middle cerebral artery infarction. ( 27942881 )
2017
19
Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach. ( 29202815 )
2017
20
Fluid Intake Related to Brain Edema in Acute Middle Cerebral Artery Infarction. ( 26666449 )
2016
21
Decompressive craniectomy for malignant middle cerebral artery infarction in a 16-year old boy: a case report. ( 27998316 )
2016
22
Malignant Middle Cerebral Artery Infarction Secondary to Traumatic Bilateral Internal Carotid Artery Dissection. A Case Report. ( 29967852 )
2016
23
De novo glioblastoma in the territory of a recent middle cerebral artery infarction and a residual meningioma: pathogenesis revisited. ( 27091344 )
2016
24
Malignant middle cerebral artery infarction: An unusual but severe neurovascular condition. ( 27147151 )
2016
25
Impact of timing of cranioplasty on hydrocephalus after decompressive hemicraniectomy in malignant middle cerebral artery infarction. ( 28012353 )
2016
26
Identification of cytokines for early prediction of malignant middle cerebral artery infarction. ( 26981614 )
2016
27
Analysis of the Outcome and Prognostic Factors of Decompressive Craniectomy between Young and Elderly Patients for Acute Middle Cerebral Artery Infarction. ( 27847759 )
2016
28
Reduction of Midline Shift Following Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Infarction. ( 27733025 )
2016
29
Neurologic Functional Outcomes of Decompressive Hemicraniectomy Versus Conventional Treatment for Malignant Middle Cerebral Artery Infarction: A Systematic Review and Meta-Analysis. ( 28024976 )
2016
30
Predictive factors for decompressive hemicraniectomy in malignant middle cerebral artery infarction. ( 26923797 )
2016
31
10-Year Institutional Retrospective Case Series of Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction (mMCAI). ( 27639522 )
2016
32
Clinical course, prognostic factors, and long-term outcomes of malignant middle cerebral artery infarction patients in the modern era. ( 27147150 )
2016
33
Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction: A Case-Control Study. ( 27443695 )
2016
34
Crossed cerebellar diaschisis in patients with acute middle cerebral artery infarction: Occurrence and perfusion characteristics. ( 26661242 )
2016
35
Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Infarction: The 'Real World' Beyond Studies. ( 27379413 )
2016
36
Predicting Mortality in Patients With "Malignant" Middle Cerebral Artery Infarction Using Susceptibility-Weighted Magnetic Resonance Imaging: Preliminary Findings. ( 26937906 )
2016
37
Decompressive craniectomy in malignant middle cerebral artery infarction: To be, or not to be? ( 29443256 )
2016
38
Prediction of Malignant Middle Cerebral Artery Infarction in Elderly Patients. ( 27009609 )
2016
39
Decompressive craniectomy 116a88h after malignant middle cerebral artery infarction. ( 26892675 )
2016
40
Functional Outcomes of Decompressive Craniectomy in Patients with Malignant Middle Cerebral Artery Infarction and Their Association with Preoperative Thalamus Deformation: An Analysis of 12 Patients. ( 27477404 )
2016
41
Decompressive craniectomy for severe middle cerebral artery infarction: a meta-analysis of randomised controlled trials. ( 27968912 )
2016
42
Association Between Prolonged Seizures and Malignant Middle Cerebral Artery Infarction in Children With Acute Ischemic Stroke. ( 27663488 )
2016
43
Large Size Hemicraniectomy Reduces Early Herniation in Malignant Middle Cerebral Artery Infarction. ( 26855236 )
2016
44
Serum malondialdehyde levels in patients with malignant middle cerebral artery infarction are associated with mortality. ( 25933254 )
2015
45
Atypical Unilateral Posterior Reversible Encephalopathy Syndrome Mimicking a Middle Cerebral Artery Infarction. ( 26356795 )
2015
46
Serum tissue inhibitor of matrix metalloproteinase-1 levels are associated with mortality in patients with malignant middle cerebral artery infarction. ( 26162891 )
2015
47
Malignant middle cerebral artery infarction: a clinical study of 32 patients. ( 25857586 )
2015
48
Ethical considerations for craniectomy in malignant middle cerebral artery infarction: should we still deny our patient a life-saving procedure? ( 26404880 )
2015
49
Effect of Donepezil on Wernicke Aphasia After Bilateral Middle Cerebral Artery Infarction: Subtraction Analysis of Brain F-18 Fluorodeoxyglucose Positron Emission Tomographic Images. ( 26166237 )
2015
50
Effect of Intravenous Thrombolysis on the Time Course of the Apparent Diffusion Coefficient in Acute Middle Cerebral Artery Infarction. ( 25895155 )
2015

Variations for Middle Cerebral Artery Infarction

Expression for Middle Cerebral Artery Infarction

Search GEO for disease gene expression data for Middle Cerebral Artery Infarction.

Pathways for Middle Cerebral Artery Infarction

Pathways related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 EDN1 ENO2

GO Terms for Middle Cerebral Artery Infarction

Cellular components related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CD40LG EDN1 ENO2 PLAT S100B

Biological processes related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 8.62 EDN1 S100B

Molecular functions related to Middle Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 EDN1 PLAT S100B

Sources for Middle Cerebral Artery Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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