MCID: MDD004
MIFTS: 25

Middle Ear Adenocarcinoma

Categories: Cancer diseases, Ear diseases

Aliases & Classifications for Middle Ear Adenocarcinoma

MalaCards integrated aliases for Middle Ear Adenocarcinoma:

Name: Middle Ear Adenocarcinoma 12 15 71
Adenocarcinoma of the Middle Ear 12
Adenocarcinoma of Middle Ear 12

Classifications:



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Disease Ontology 12 DOID:4892
NCIt 49 C6848
UMLS 71 C1334758

Summaries for Middle Ear Adenocarcinoma

Disease Ontology : 12 A middle ear carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Middle Ear Adenocarcinoma, also known as adenocarcinoma of the middle ear, is related to middle ear adenoma and ceruminoma. An important gene associated with Middle Ear Adenocarcinoma is PPY (Pancreatic Polypeptide), and among its related pathways/superpathways is Cytoskeleton remodeling Neurofilaments. Affiliated tissues include breast, colon and bone, and related phenotype is digestive/alimentary.

Related Diseases for Middle Ear Adenocarcinoma

Diseases related to Middle Ear Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 middle ear adenoma 30.0 PPY KRT7 KRT5
2 ceruminoma 30.0 PPY KRT7 KRT5
3 endometrial small cell carcinoma 10.4 PPY AFP
4 auditory system cancer 10.3 PPY KRT7
5 adenoid basal cell carcinoma 10.3 KRT7 ACIN1
6 pancreatic endocrine carcinoma 10.3 PPY AFP
7 intrahepatic bile duct adenoma 10.3 KRT7 AFP
8 mature teratoma 10.3 KRT7 AFP
9 rete testis neoplasm 10.3 KRT7 AFP
10 rete testis adenocarcinoma 10.3 KRT7 AFP
11 renal pelvis adenocarcinoma 10.3 KRT7 AFP
12 bile duct cystadenocarcinoma 10.3 KRT7 AFP
13 ovarian primitive germ cell tumor 10.3 KRT7 AFP
14 ovarian endodermal sinus tumor 10.3 KRT7 AFP
15 ovarian wilms' cancer 10.3 KRT7 AFP
16 intratubular embryonal carcinoma 10.3 KRT7 AFP
17 lymphangioma 10.3 PECAM1 AFP
18 inverted transitional papilloma 10.3 KRT7 KRT5
19 malignant spiradenoma 10.3 KRT7 KRT5
20 ureter adenocarcinoma 10.3 KRT7 KRT5
21 benign breast adenomyoepithelioma 10.3 KRT7 KRT5
22 pineal gland cancer 10.3 GFAP AFP
23 breast adenomyoepithelioma 10.3 KRT7 KRT5
24 subareolar duct papillomatosis 10.3 KRT7 KRT5
25 cystadenofibroma 10.3 KRT7 AFP
26 nipple neoplasm 10.3 KRT7 KRT5
27 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
28 sarcomatous intrahepatic cholangiocarcinoma 10.3 KRT7 AFP
29 external ear carcinoma 10.3 KRT7 KRT5
30 immature teratoma of ovary 10.3 TG AFP
31 vulvar apocrine adenocarcinoma 10.3 KRT7 KRT5
32 apocrine adenocarcinoma 10.3 KRT7 KRT5
33 gastric squamous cell carcinoma 10.3 KRT7 KRT5
34 gallbladder leiomyosarcoma 10.3 PECAM1 AFP
35 adenocarcinoma 10.3
36 breast myoepithelial neoplasm 10.3 KRT7 KRT5
37 mature teratoma of the ovary 10.3 TG AFP
38 eccrine papillary adenocarcinoma 10.3 KRT7 KRT5
39 necrotizing sialometaplasia 10.3 KRT7 KRT5
40 bile duct mucoepidermoid carcinoma 10.2 KRT7 KRT5
41 breast metaplastic carcinoma 10.2 KRT7 KRT5
42 breast mucinous carcinoma 10.2 KRT7 KRT5
43 clear cell hidradenoma 10.2 KRT7 KRT5
44 hidradenoma 10.2 KRT7 KRT5
45 eccrine sweat gland cancer 10.2 KRT7 KRT5
46 sweat gland cancer 10.2 KRT7 KRT5
47 metatypical basal cell carcinoma 10.2 KRT7 KRT5
48 pericardium cancer 10.2 KRT7 KRT5
49 nephrogenic adenoma of the urethra 10.2 KRT7 KRT5
50 urethral benign neoplasm 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Middle Ear Adenocarcinoma:



Diseases related to Middle Ear Adenocarcinoma

Symptoms & Phenotypes for Middle Ear Adenocarcinoma

MGI Mouse Phenotypes related to Middle Ear Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 GFAP KRT5 PDX1 PECAM1 TG VWF

Drugs & Therapeutics for Middle Ear Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Middle Ear Adenocarcinoma

Genetic Tests for Middle Ear Adenocarcinoma

Anatomical Context for Middle Ear Adenocarcinoma

MalaCards organs/tissues related to Middle Ear Adenocarcinoma:

40
Breast, Colon, Bone, Spleen, Heart, Thyroid, Ovary

Publications for Middle Ear Adenocarcinoma

Articles related to Middle Ear Adenocarcinoma:

(show all 25)
# Title Authors PMID Year
1
The First Reported Case of Primary Intestinal-type Adenocarcinoma of the Middle Ear and Review of the Literature. 61
28796082 2017
2
Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium. 61
23914068 2013
3
Aggressive low grade middle ear adenocarcinoma with multiple recurrences: a case report. 61
21736736 2011
4
[Amphicrine adenoma of the middle ear: three cases reports and a review of the literature]. 61
17007186 2006
5
[Peripheral facial paralysis in adenocarcinoma of the middle ear]. 61
15987042 2005
6
[Peripheral facial paralysis caused by an adenocarcinoma of the middle ear]. 61
15929336 2005
7
Aggressive papillary tumour of the nasopharynx followed by an aggressive papillary tumour of the middle ear. A multiple site tumour? 61
14738614 2003
8
Middle ear adenocarcinoma with intracranial extension. Case report. 61
10067929 1999
9
Primary poorly differentiated adenocarcinoma of the middle ear. 61
7980195 1994
10
Adenocarcinoma of the middle ear with osteolysis of the tympanic bulla in a cat. 61
1506254 1992
11
Papillary adenocarcinoma of the middle ear. 61
1702457 1990
12
[Primary adenocarcinoma of the middle ear]. 61
2322360 1990
13
Adenoma and adenocarcinoma of the middle ear and mastoid cavity. 61
2084984 1990
14
Multiple head and neck neoplasia following radiation for benign disease during childhood. 61
3379963 1988
15
Primary adenocarcinoma of the middle ear and temporal bone. 61
3620141 1987
16
Primary adenocarcinoma of the temporal bone with posterior fossa extension: case report. 61
3713411 1986
17
Primary adenomatous neoplasm of the middle ear. 61
6690880 1984
18
Primary adenocarcinoma of the middle ear. 61
6410329 1983
19
Metastatic colon adenocarcinoma of the middle ear. 61
6626022 1983
20
Primary adenocarcinoma of the middle ear. 61
6816047 1982
21
Primary adenocarcinoma of the middle ear. 61
7333222 1981
22
Primary adenocarcinoma of the middle ear. 61
1200915 1975
23
Primary adenocarcinoma of the middle ear. 61
1147828 1975
24
Primary adenocarcinoma of the middle ear. Report of three cases. 61
13912602 1961
25
Adenocarcinoma of the middle ear. 61
13789168 1961

Variations for Middle Ear Adenocarcinoma

Expression for Middle Ear Adenocarcinoma

Search GEO for disease gene expression data for Middle Ear Adenocarcinoma.

Pathways for Middle Ear Adenocarcinoma

Pathways related to Middle Ear Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 KRT7 KRT5 GFAP

GO Terms for Middle Ear Adenocarcinoma

Cellular components related to Middle Ear Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT7 KRT5 GFAP

Biological processes related to Middle Ear Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 8.8 VWF PDX1 GFAP

Sources for Middle Ear Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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