Middle Ear Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Middle Ear Adenoma

MalaCards integrated aliases for Middle Ear Adenoma:

Name: Middle Ear Adenoma ¹¹ ¹⁴ ⁷¹

Adenoma of the Middle Ear ¹¹

Adenoma of Middle Ear ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases Ear diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5387

NCIt ⁴⁹ C6834

SNOMED-CT ⁶⁸ 734078009

UMLS ⁷¹ C1334759

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Summaries for Middle Ear Adenoma

Disease Ontology: ¹¹ A sensory organ benign neoplasm that is located in the middle ear.

MalaCards based summary: Middle Ear Adenoma, also known as adenoma of the middle ear, is related to adenoma and carcinoid tumors, intestinal. An important gene associated with Middle Ear Adenoma is SYP (Synaptophysin), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include middle ear, salivary gland and bone.

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Related Diseases for Middle Ear Adenoma

Diseases related to Middle Ear Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)

#	Related Disease	Score	Top Affiliating Genes
1	adenoma	31.0	SYP KRT7 CHGA
2	carcinoid tumors, intestinal	30.5	SYP ENO2 CHGA
3	carcinoid syndrome	30.4	SYP ENO2 CHGA
4	glomus tumor	30.2	SYP ENO2
5	neuroendocrine tumor	29.9	SYP NCAM1 ENO2 CHGA
6	hidradenoma	29.8	KRT7 KRT5
7	eccrine acrospiroma	29.8	KRT7 KRT5
8	middle ear adenocarcinoma	29.7	PPY KRT7 KRT5
9	paraganglioma	29.6	SYP NCAM1 KRT7 ENO2 CHGA
10	ceruminoma	29.6	PPY KRT7 KRT5
11	meningioma, familial	29.5	SYP NCAM1 ENO2
12	basal cell carcinoma	28.9	SYP KRT7 KRT5 ENO2 CHGA
13	bell's palsy	10.4
14	rare tumor	10.4
15	facial paralysis	10.3
16	otorrhea	10.3
17	cholesteatoma of middle ear	10.3
18	pleomorphic adenoma	10.2
19	granular cell tumor	10.2	SYP ENO2
20	malignant melanocytic neoplasm of the peripheral nerve sheath	10.2	SYP ENO2
21	neuronal intestinal dysplasia, type b	10.2	SYP ENO2
22	optic nerve astrocytoma	10.2	SYP ENO2
23	pineal region teratoma	10.2	SYP ENO2
24	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.2	SYP ENO2
25	bile duct mucinous adenocarcinoma	10.2	SYP ENO2
26	partial cryptophthalmia	10.2	SYP ENO2
27	intracranial primitive neuroectodermal tumor	10.2	SYP ENO2
28	cerebellar liponeurocytoma	10.2	SYP ENO2
29	frontal lobe neoplasm	10.2	SYP ENO2
30	lipoma of spermatic cord	10.2	SYP ENO2
31	melanotic neuroectodermal tumor	10.2	SYP ENO2
32	paratesticular lipoma	10.2	SYP ENO2
33	mucinous cystadenofibroma	10.2	SYP KRT7
34	prostate small cell carcinoma	10.2	SYP ENO2
35	perivascular tumor	10.2	SYP ENO2
36	central nervous system mesenchymal non-meningothelial tumor	10.2	SYP ENO2
37	ectomesenchymoma	10.2	SYP ENO2
38	mature teratoma of the ovary	10.2	SYP ENO2
39	myoblastoma	10.2	SYP ENO2
40	spinal cord oligodendroglioma	10.2	SYP ENO2
41	ovary neuroendocrine neoplasm	10.2	SYP KRT7
42	cerebellar medulloblastoma	10.2	SYP ENO2
43	askin's tumor	10.2	SYP ENO2
44	endometrial transitional cell carcinoma	10.2	SYP KRT7
45	rectum neuroendocrine neoplasm	10.2	SYP KRT7
46	small cell osteogenic sarcoma	10.2	SYP ENO2
47	cystitis cystica	10.1	SYP KRT7
48	horner's syndrome	10.1	SYP ENO2
49	anal paget's disease	10.1	SYP KRT7
50	medulloepithelioma	10.1	SYP ENO2

Graphical network of the top 20 diseases related to Middle Ear Adenoma:

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Symptoms & Phenotypes for Middle Ear Adenoma

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Drugs & Therapeutics for Middle Ear Adenoma

Search Clinical Trials, NIH Clinical Center for Middle Ear Adenoma

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Genetic Tests for Middle Ear Adenoma

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Anatomical Context for Middle Ear Adenoma

Organs/tissues related to Middle Ear Adenoma:

FMA: Middle Ear

MalaCards : Salivary Gland, Bone

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Publications for Middle Ear Adenoma

Articles related to Middle Ear Adenoma:

(show top 50) (show all 117)

#	Title	Authors	PMID	Year
1	Middle ear adenoma with facial palsy: A case report and a review of the literature. ⁶²	Shishido T...Katori Y	33246746	2022
2	Middle Ear "Adenoma": a Neuroendocrine Tumor with Predominant L Cell Differentiation. ⁶²	Asa SL...Mete O	34041698	2021
3	Middle Ear Adenoma Imitating Late Postoperative Complication. ⁶²	Fedorova K...Kominek P	32579388	2021
4	Clinical and histopathological principles for the diagnosis of a recurrent paraganglioma of the jugular foramen initially diagnosed as a middle ear adenoma: illustrative case. ⁶²	Breton JM...Heilman CB	36131578	2021
5	Preoperative Diagnosis and Treatment of Middle Ear Adenoma: A Case Report and Literature Review. ⁶²	Zwierz A...Burduk P	33719615	2021
6	Treatment with somatostatin analogues and PRRT in metastatic middle ear adenoma with neuroendocrine features. ⁶²	Lima Ferreira J...Hofland J	33982661	2021
7	Neuroendocrine adenoma of the middle ear-An intriguing entity. ⁶²	Bou Rahal P...Wangberg B	33768844	2021
8	111In-Octreoscan SPECT/CT hybrid imaging and 68Ga-DOTANOC PET/CT in neuroendocrine adenoma of the middle ear (NAME). ⁶²	Pontico M...De Vincentis G	33273780	2020
9	Middle ear adenoma with neuroendocrine differentiation: Report of a rare case. ⁶²	Yadav SK...Pruthi SK	32129301	2020
10	[A rare pathology of the petrous part of the temporal bone: adenoma of the middle ear]. ⁶²	Sudhoff H...Todt I	31531685	2020
11	Middle Ear Neuroendocrine Adenoma: A Case Report and Literature Review. ⁶²	Bruschini L...Forli F	33425416	2020
12	[Clinicopathological characteristics and research progress of neuroendocrine adenoma of the middle ear]. ⁶²	He SJ...Zhang RY	31495105	2019
13	Neuroendocrine Adenoma of Middle Ear Causing Acute Onset Facial Palsy- A Rare Case Report. ⁶²	Zaman SU...Aqil S	31598498	2019
14	Neuroendocrine neoplasms of the middle ear: report of 2 cases and review of the literature. ⁶²	He S...Wang W	31934190	2019
15	Primary pleomorphic adenoma of the middle ear and mastoid. ⁶²	Bitew A...Redleaf M	30273440	2018
16	INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors. ⁶²	Rooper LM...Westra WH	29438167	2018
17	The First Reported Case of Primary Intestinal-type Adenocarcinoma of the Middle Ear and Review of the Literature. ⁶²	Nader ME...Gidley PW	28796082	2017
18	Neuroendocrine adenoma of the middle ear presented as paragaglioma: a case report. ⁶²	Tsiouvaka S...Skoulakis C	30944513	2017
19	Middle ear adenoma with uncommon presentation and literature review. ⁶²	Wang L...Liu QY	28611057	2017
20	Middle ear adenoma with neuroendocrine differentiation : A pediatric case report. ⁶²	Sterrer E...Loader B	27761737	2017
21	[Violation with horizontal semicircular canal of the middle ear adenoma: a case report]. ⁶²	Zhu MC...Gong XR	28219173	2017
22	Neuroendocrine adenoma of middle ear with new bone formation and review of literature. ⁶²	Hu H...Yuen HW	26954862	2016
23	Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis. ⁶²	Hasan Z...da Cruz M	27429819	2016
24	[Middle ear adenoma: clinical and pathologic analysis]. ⁶²	Bai Y...Liu H	26888509	2015
25	Adenomatous tumors of the middle ear. ⁶²	Pelosi S...Koss S	25769353	2015
26	'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. ⁶²	Agaimy A...Hornung J	24766278	2015
27	Recurrent neuroendocrine adenoma of the middle ear: a case report. ⁶²	Gobel Y...Marianowski R	24986258	2014
28	"Neuroendocrine adenoma of the middle ear with the history of otitis media and carcinoma of the cheek: a case report". ⁶²	Almuhanna K	25123111	2014
29	A rare case of middle ear adenoma. ⁶²	Baku M...Ueda H	25741045	2014
30	Neuroendocrine adenoma of the middle ear confused with congenital cholesteatoma. ⁶²	Kim YH...Jung DJ	24830979	2014
31	[Neuroendocrine adenoma of the middle ear]. ⁶²	Gut SM...Linder T	24610086	2014
32	Neuroendocrine neoplasms of the head and neck: some suggestions for the new WHO classification of head and neck tumors. ⁶²	Xu B...Perez-Ordonez B	24595420	2014
33	Middle ear adenoma: case report and discussion. ⁶²	Isenring D...Huber AM	25045567	2014
34	Middle ear adenoma with neuroendocrine differentiation: relate of two cases and literature review. ⁶²	Bittencourt AG...Bento RF	25992031	2013
35	[One case of invasive adenoma of the middle ear]. ⁶²	Yao K...Zhang MS	22932248	2012
36	Huge middle ear adenoma with delayed facial nerve paralysis. ⁶²	Lee SH...Kim KS	22711394	2012
37	A case of middle ear adenoma. ⁶²	Shim MJ...Yoon TH	24653866	2012
38	Endolymphatic sac tumor: case report and review of the literature. ⁶²	Sun YH...Xu MQ	22472343	2012
39	Adenomatous tumors of the middle ear and temporal bone: clinical, morphological and tumor biological characteristics of challenging neoplastic lesions. ⁶²	Duderstadt M...Ostertag H	21863251	2012
40	Neuroendocrine adenoma of the middle ear. ⁶²	Cruz Toro P...Amilibia E	21527867	2012
41	Neuroendocrine adenoma of the middle ear with extension into the external auditory canal. ⁶²	Kacerovska D...Kazakov D	22716008	2012
42	A white mass behind the tympanic membrane: adenoma of the middle ear with neuroendocrine differentiation. ⁶²	Verhage-Damen GW...Kunst HP	21659937	2011
43	Neuroendocrine adenoma of the middle ear (NAME) mimicking as chronic otitis media with an episode of facial nerve palsy. ⁶²	Tomazic PV...Walch C	21838097	2011
44	[Middle ear adenoma]. ⁶²	Medina EA...Arias VL	20436986	2009
45	Middle ear adenoma: a challenging diagnosis. ⁶²	Zan E...Yousem DM	19369616	2009
46	Middle ear adenoma with neuroendocrine differentiation (MEA-ND) in the pediatric population. ⁶²	Dogru S...Smith RJ	19303146	2009
47	Primary extracranial meningiomas: an analysis of 146 cases. ⁶²	Rushing EJ...Thompson LD	19644540	2009
48	Neuroendocrine adenoma of the middle ear (NAME). ⁶²	Leong K...Sataloff RT	19358129	2009
49	Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series. ⁶²	Saliba I...Evrard AS	20111612	2009
50	[Middle ear adenoma/middle ear carcinoid--an unproblematic tumor?]. ⁶²	Strehl MA...Volker HU	19065497	2009

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Genes for Middle Ear Adenoma

Genes related to Middle Ear Adenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SYP	Synaptophysin	Protein Coding	6.79	DISEASES inferred ¹⁴
2	PPY	Pancreatic Polypeptide	Protein Coding	6.73	DISEASES inferred ¹⁴
3	ENO2	Enolase 2	Protein Coding	6.5	DISEASES inferred ¹⁴
4	KRT7	Keratin 7	Protein Coding	6.23	DISEASES inferred ¹⁴
5	CHGA	Chromogranin A	Protein Coding	5.9	DISEASES inferred ¹⁴
6	KRT5	Keratin 5	Protein Coding	5.24	DISEASES inferred ¹⁴
7	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	5.17	DISEASES inferred ¹⁴

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Variations for Middle Ear Adenoma

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Expression for Middle Ear Adenoma

Search GEO for disease gene expression data for Middle Ear Adenoma.

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Pathways for Middle Ear Adenoma

Pathways related to Middle Ear Adenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	11.33	SYP NCAM1 ENO2

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GO Terms for Middle Ear Adenoma

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Sources for Middle Ear Adenoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MDD008 MIFTS: 25	Middle Ear Adenoma Categories: Cancer diseases, Ear diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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