MCID: MDD009
MIFTS: 26

Middle Ear Carcinoma

Categories: Cancer diseases, Ear diseases, Neuronal diseases

Aliases & Classifications for Middle Ear Carcinoma

MalaCards integrated aliases for Middle Ear Carcinoma:

Name: Middle Ear Carcinoma 12 15 73
Carcinoma of the Middle Ear 12
Neoplasm of the Middle Ear 29
Carcinoma of Middle Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4893
NCIt 50 C6089
ICD10 33 C30.1
UMLS 73 C1334760

Summaries for Middle Ear Carcinoma

Disease Ontology : 12 A middle ear cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

MalaCards based summary : Middle Ear Carcinoma, also known as carcinoma of the middle ear, is related to middle ear squamous cell carcinoma and middle ear adenocarcinoma. An important gene associated with Middle Ear Carcinoma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are MicroRNAs in cancer and IL-17 Family Signaling Pathways. Related phenotype is Reduced mammosphere formation.

Related Diseases for Middle Ear Carcinoma

Diseases related to Middle Ear Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 middle ear squamous cell carcinoma 31.1 MMP9 RECK
2 middle ear adenocarcinoma 11.0
3 otitis media 9.7
4 squamous cell carcinoma 9.7
5 neurofibroma 9.7
6 bone cancer 9.3 MMP9 RECK
7 cholangiocarcinoma 9.0 MMP9 RECK
8 ovarian cancer 8.6 CSF3 MMP9 RECK

Graphical network of the top 20 diseases related to Middle Ear Carcinoma:



Diseases related to Middle Ear Carcinoma

Symptoms & Phenotypes for Middle Ear Carcinoma

GenomeRNAi Phenotypes related to Middle Ear Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.8 CD1A CSF3 RECK

Drugs & Therapeutics for Middle Ear Carcinoma

Search Clinical Trials , NIH Clinical Center for Middle Ear Carcinoma

Genetic Tests for Middle Ear Carcinoma

Genetic tests related to Middle Ear Carcinoma:

# Genetic test Affiliating Genes
1 Neoplasm of the Middle Ear 29

Anatomical Context for Middle Ear Carcinoma

Publications for Middle Ear Carcinoma

Articles related to Middle Ear Carcinoma:

(show all 11)
# Title Authors Year
1
Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma. ( 27384159 )
2016
2
Intramastoid solitary neurofibroma mimicking middle ear carcinoma. ( 26788355 )
2015
3
Computed tomography and magnetic resonance imaging findings for primary middle-ear carcinoma. ( 23635547 )
2013
4
Middle ear carcinoma originating from a primary acquired cholesteatoma: a case report. ( 15699729 )
2005
5
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. ( 10077254 )
1999
6
Significance of tubal resection in surgical treatment of middle ear carcinoma. ( 9151022 )
1997
7
Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media. ( 9094989 )
1997
8
Synchronous bilateral middle ear carcinoma. ( 8172837 )
1994
9
Middle-ear carcinoma in a girl of eighteen. ( 7391668 )
1980
10
[Middle ear carcinoma]. ( 967743 )
1976
11
Middle-Ear Carcinoma. ( 29645700 )
1928

Variations for Middle Ear Carcinoma

Expression for Middle Ear Carcinoma

Search GEO for disease gene expression data for Middle Ear Carcinoma.

Pathways for Middle Ear Carcinoma

Pathways related to Middle Ear Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 MMP9 RECK
2
Show member pathways
11.65 CSF3 MMP9
3
Show member pathways
11.25 MMP9 RECK
4 11.14 CD1A CSF3
5 10.91 MMP9 RECK
6 10.42 CSF3 MMP9

GO Terms for Middle Ear Carcinoma

Biological processes related to Middle Ear Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.26 CSF3 MMP9
2 extracellular matrix organization GO:0030198 9.16 MMP9 RECK
3 embryo implantation GO:0007566 8.96 MMP9 RECK
4 macrophage differentiation GO:0030225 8.62 CSF3 MMP9

Sources for Middle Ear Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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