MCID: MDD009
MIFTS: 28

Middle Ear Carcinoma

Categories: Cancer diseases, Ear diseases, Neuronal diseases

Aliases & Classifications for Middle Ear Carcinoma

MalaCards integrated aliases for Middle Ear Carcinoma:

Name: Middle Ear Carcinoma 12 15 70
Carcinoma of the Middle Ear 12
Carcinoma of Middle Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4893
NCIt 50 C6089
ICD10 32 C30.1
UMLS 70 C1334760

Summaries for Middle Ear Carcinoma

Disease Ontology : 12 A middle ear cancer that has material basis in abnormally proliferating cells derives from epithelial cells.

MalaCards based summary : Middle Ear Carcinoma, also known as carcinoma of the middle ear, is related to middle ear squamous cell carcinoma and auditory system cancer. An important gene associated with Middle Ear Carcinoma is RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Spinal Cord Injury. Affiliated tissues include bone, brain and breast, and related phenotypes are immune system and skeleton

Related Diseases for Middle Ear Carcinoma

Diseases related to Middle Ear Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 middle ear squamous cell carcinoma 32.0 RECK MMP9 CDKN2A
2 auditory system cancer 30.5 RECK PPY
3 verrucous carcinoma 30.5 MMP9 KRT5 CDKN2A
4 external ear carcinoma 30.0 KRT7 KRT5
5 adenoid cystic carcinoma 30.0 MMP9 KRT7 KRT5 CDKN2A
6 keratinizing squamous cell carcinoma 29.8 KRT7 KRT5 CDKN2A
7 basal cell carcinoma 29.7 MMP9 KRT7 KRT5 CDKN2A CD68
8 middle ear adenocarcinoma 29.5 TG PPY PDX1 KRT7 KRT5 GFAP
9 mucoepidermoid carcinoma 29.3 TG KRT7 KRT5 EWSR1 CDKN2A
10 rhabdomyosarcoma 28.8 WT1 KRT7 GFAP EWSR1 CDKN2A
11 light chain deposition disease 10.3 MMP9 CD68
12 villonodular synovitis 10.3 MMP9 CD68
13 histiocytic sarcoma 10.3 CDKN2A CD68
14 granulomatous orchitis 10.3 CD68 AFP
15 lymphohistiocytoid mesothelioma 10.3 CDKN2A CD68
16 penile urethral cancer 10.3 KRT5 CDKN2A
17 epidermolytic acanthoma 10.3 CDKN2A CD68
18 male urethral cancer 10.3 KRT5 CDKN2A
19 perforated corneal ulcer 10.3 MMP9 CD68
20 vulva basal cell carcinoma 10.3 KRT5 CDKN2A
21 laryngeal small cell carcinoma 10.3 KRT5 CDKN2A
22 acanthoma 10.2 KRT5 CDKN2A
23 sarcomatoid basal cell carcinoma 10.2 KRT5 EWSR1
24 germ cell cancer 10.2 RECK CSF3 AFP
25 bone squamous cell carcinoma 10.2 RECK MMP9 CDKN2A
26 sarcomatoid squamous cell skin carcinoma 10.2 KRT5 CD68
27 testicular germ cell cancer 10.2 RECK CSF3 AFP
28 immature teratoma of ovary 10.2 TG AFP
29 otitis media 10.2
30 binswanger's disease 10.2 RECK GFAP
31 mature teratoma of the ovary 10.2 TG AFP
32 ischemic fasciitis 10.2 CDKN2A CD68
33 tenosynovial giant cell tumor 10.2 CDKN2A CD68
34 cutaneous leiomyosarcoma 10.2 GFAP CD68
35 angiokeratoma of fordyce 10.2 WT1 MMP9
36 fallopian tube squamous cell carcinoma 10.2 WT1 CDKN2A
37 thyroid lymphoma 10.2 TG CDKN2A
38 breast cystic hypersecretory carcinoma 10.2 TG KRT5
39 pancreas sarcoma 10.2 CDKN2A CD68 AFP
40 localized osteosarcoma 10.2 EWSR1 CSF3 CDKN2A
41 angiokeratoma circumscriptum 10.2 WT1 MMP9
42 ovarian mixed germ cell neoplasm 10.1 WT1 AFP
43 pineal gland cancer 10.1 GFAP AFP
44 malignant spindle cell melanoma 10.1 CDKN2A CD68
45 juvenile type testicular granulosa cell tumor 10.1 WT1 AFP
46 testicular granulosa cell tumor 10.1 WT1 AFP
47 alzheimer disease 17 10.1 CD68 AIF1
48 cauda equina neoplasm 10.1 WT1 EWSR1
49 ovarian gonadoblastoma 10.1 WT1 AFP
50 sarcomatosis 10.1 WT1 EWSR1

Graphical network of the top 20 diseases related to Middle Ear Carcinoma:



Diseases related to Middle Ear Carcinoma

Symptoms & Phenotypes for Middle Ear Carcinoma

MGI Mouse Phenotypes related to Middle Ear Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 AIF1 CD68 CDKN2A CSF3 GFAP KRT5
2 skeleton MP:0005390 9.23 AIF1 CD68 CDKN2A MMP9 PDX1 PPY

Drugs & Therapeutics for Middle Ear Carcinoma

Search Clinical Trials , NIH Clinical Center for Middle Ear Carcinoma

Genetic Tests for Middle Ear Carcinoma

Anatomical Context for Middle Ear Carcinoma

MalaCards organs/tissues related to Middle Ear Carcinoma:

40
Bone, Brain, Breast

Publications for Middle Ear Carcinoma

Articles related to Middle Ear Carcinoma:

(show top 50) (show all 104)
# Title Authors PMID Year
1
[Analysis of the effect of one-stage revascularization with internal carotid artery resection on cervical metastatic carcinoma in advanced head and neck carcinomas]. 61
33254295 2020
2
Left Chronic Otitis Media with Squamous Cell Carcinoma of the Middle Ear and Postauricular Mastoid Fistula: A Case Report. 61
32538931 2020
3
[Atrial dissociation in a boxer with a carcinoma of the middle ear]. 61
32369024 2020
4
Temporal Bone Histopathology Case of the Month: Basal Cell Carcinoma of the Middle Ear Following Chemoradiation to the Head and Neck. 61
31157722 2019
5
Poorly Differentiated Primary Carcinoma of the Middle Ear on 18F-FDG PET/CT. 61
30371599 2019
6
[Middle ear teratoma in infant: report of three cases and review of the literatures]. 61
29429175 2018
7
Carcinoma of the Middle Ear: A Review of the National Cancer Database. 61
28692593 2017
8
Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma. 61
27384159 2017
9
Outcomes of 18 cases with squamous cell carcinoma of middle ear who underwent both surgery and post-operative radiotherapy. 61
26472473 2016
10
Intramastoid solitary neurofibroma mimicking middle ear carcinoma. 61
26788355 2015
11
Squamous cell carcinoma of the middle ear: report of three cases. 61
25932267 2015
12
[Middle ear cancer recurrence after operation+radiotherapy with adjacent tissue necrosis: two cases report]. 61
25464577 2014
13
[Imaging diagnosis of masses in temporal bone associated with pulsatile tinnitus]. 61
24360039 2013
14
Computed tomography and magnetic resonance imaging findings for primary middle-ear carcinoma. 61
23635547 2013
15
Squamous cell carcinoma of the middle ear. 61
22278861 2012
16
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. 61
22178867 2012
17
[Meta-analysis of the effects of radiotherapy and surgery on carcinoma of the middle ear]. 61
22070082 2011
18
[The otorhinolaryngological achievements of Władysław Orłowski (1835-1889)]. 61
21166147 2010
19
Primary middle ear Epstein-Barr virus-related lymphoepithelial carcinoma: case reports and systematic review. 61
19877237 2010
20
Middle ear cancer: a population-based study. 61
19373882 2009
21
Cholesteatoma triggering squamous cell carcinoma: case report and literature review of a rare tumor. 61
19563937 2009
22
High grade mucoepidermoid carcinoma of the middle ear treated with extended temporal bone resection. 61
19248700 2008
23
Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory cana--an historical series. 61
16817330 2006
24
Middle ear carcinoma originating from a primary acquired cholesteatoma: a case report. 61
15699729 2005
25
[Clinical analysis of 20 cases of carcinoma of the middle ear]. 61
14727430 2003
26
[Diagnostic problems in case of middle ear carcinoma]. 61
14994613 2003
27
[The results of treatment of middle ear carcinoma with radiotherapy]. 61
10917060 2000
28
[Histopathological studies of intratemporal growth behavior of middle ear carcinoma]. 61
10689676 2000
29
Primary basal cell carcinoma of the middle ear presenting as recurrent cholesteatoma. 61
10503590 1999
30
Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear. 61
9828819 1998
31
[Middle ear carcinoma]. 61
9644865 1998
32
En bloc resection of the temporal bone by the lateral approach in carcinoma of the middle ear associated with skull base infiltration with reference to the resection of the petrous apex. 61
17171066 1998
33
[En bloc resection of the temporal bone for middle ear carcinoma extending to the cranial base]. 61
9277100 1997
34
Prevalence of human papillomavirus in middle ear carcinoma associated with chronic otitis media. 61
9094989 1997
35
Significance of tubal resection in surgical treatment of middle ear carcinoma. 61
9151022 1997
36
[Low-grade papillary adenocarcinoma of the endolymphatic sac. Report of three cases with immunohistochemical study]. 61
9172616 1996
37
Mucoepidermoid carcinoma of the middle ear-a case report. 61
8730361 1996
38
[Malignant tumors of the petrous bone. Apropos of 25 cases]. 61
8745697 1995
39
[Treatment of the squamous carcinoma of the middle ear]. 61
7742022 1994
40
Synchronous bilateral middle ear carcinoma. 61
8172837 1994
41
[A case of middle ear carcinoma with high plasma G-CSF level]. 61
7682610 1993
42
Primary adenoid cystic carcinoma of the middle ear and mastoid. 61
8385874 1993
43
Temporal bone resections for carcinoma of the middle ear and the external ear canal. 61
1463116 1992
44
[Implantation metastasis of adenocarcinoma of the paranasal sinuses in the middle ear]. 61
1571061 1992
45
MR and CT of squamous cell carcinoma of the middle ear and mastoid complex. 61
1950914 1991
46
Squamous carcinoma of the temporal bone: a revised staging. 61
2040835 1991
47
Unusual presentation of squamous cell carcinoma of the middle ear and mastoid. 61
1999665 1991
48
Bilateral squamous cell carcinoma of the middle ear. 61
2394631 1990
49
Carcinoma of the ear: retrospective analysis of 61 patients. 61
2760515 1989
50
Basal cell carcinoma of the middle ear--a natural history. 61
3199014 1988

Variations for Middle Ear Carcinoma

Expression for Middle Ear Carcinoma

Search GEO for disease gene expression data for Middle Ear Carcinoma.

Pathways for Middle Ear Carcinoma

Pathways related to Middle Ear Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 WT1 PDX1 AFP
2 11.21 MMP9 GFAP AIF1
3
Show member pathways
10.83 KRT7 KRT5 GFAP

GO Terms for Middle Ear Carcinoma

Sources for Middle Ear Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....