MCID: MDD010
MIFTS: 44

Middle Ear Disease

Categories: Ear diseases, Fetal diseases, Rare diseases
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Aliases & Classifications for Middle Ear Disease

MalaCards integrated aliases for Middle Ear Disease:

Name: Middle Ear Disease 11 14
Disorder of Middle Ear 71
Middle Ear Anomaly 58

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 11 DOID:5100
NCIt 49 C27065
SNOMED-CT 68 155260002
ICD10 via Orphanet 32 Q16.3 Q16.4
UMLS via Orphanet 72 C0266599
Orphanet 58 ORPHA164004
UMLS 71 C0271428

Summaries for Middle Ear Disease

MalaCards based summary: Middle Ear Disease, also known as disorder of middle ear, is related to mastoiditis and otitis media. An important gene associated with Middle Ear Disease is CFAP47 (Cilia And Flagella Associated Protein 47), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Racephedrine and Phenylephrine have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and brain, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Middle Ear Disease

Diseases related to Middle Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 851)
# Related Disease Score Top Affiliating Genes
1 mastoiditis 32.2 RSPH4A PRTN3 DHRS2 CRP CD4
2 otitis media 31.4 TNF TLR2 MUC5B MUC5AC IL6 IL1B
3 otitis externa 31.0 IL6 CRP CD4
4 otorrhea 30.9 RSPH4A DNAH11 DHRS2 CRP
5 suppurative otitis media 30.8 MUC5B MUC5AC FBXO11 DHRS2 CRP
6 chronic purulent otitis media 30.8 TLR2 MUC5B MUC5AC FBXO11 DHRS2
7 haemophilus influenzae 30.7 TNF TLR2 IL1B CXCL8
8 labyrinthitis 30.7 TNF IL1B CRP
9 intracranial abscess 30.7 CRP CD4
10 bell's palsy 30.7 TNF IL6 CRP CD4
11 upper respiratory tract disease 30.6 TNF SERPINA3 IL6 CFAP47 CD4 CCR6
12 common cold 30.5 TNF MUC5AC IL6 IL1B CXCL8 CRP
13 rhinitis 30.5 TNF IL6 IL1B CXCL8
14 gastroesophageal reflux 30.5 TNF IL6 IL1B CXCL8
15 external ear disease 30.5 IL6 CRP CD4
16 pleural empyema 30.5 IL6 CRP CD4
17 facial paralysis 30.5 TNF PRTN3 IL6 CRP CD4
18 adenoid hypertrophy 30.4 IL6 CXCL8 CD4
19 adult syndrome 30.4 TNF IL6 CRP
20 nasopharyngitis 30.4 TNF IL6 CRP CCR6
21 esophagitis 30.4 TNF IL6 IL1B CXCL8
22 ciliary dyskinesia, primary, 1 30.3 RSPH4A DNAI1 DNAH5 DNAH11
23 acquired immunodeficiency syndrome 30.3 TNF IL6 IL1B CRP CD4
24 tonsillitis 30.2 TNF TLR2 IL6 IL1B CXCL8
25 hypersensitivity vasculitis 30.2 TNF SERPINA3 PRTN3 IL6 CRP CD4
26 vasculitis 30.1 TNF SERPINA3 PRTN3 IL6 IL1B CXCL8
27 cystic fibrosis 30.0 TNF TLR2 PRTN3 MUC5B MUC5AC IL6
28 primary ciliary dyskinesia 30.0 RSPH4A MUC5B MUC5AC DNAI1 DNAH5 DNAH11
29 asthma 29.9 TNF TLR2 SERPINA3 PRTN3 MUC5B MUC5AC
30 adhesive otitis media 11.5
31 isolated congenital auditory ossicle malformation 11.1
32 cholesteatoma of middle ear 10.6
33 cleft palate, isolated 10.5
34 histiocytosis 10.5 TNF SERPINA3 CCR6
35 external pathological resorption 10.5 TNF IL6
36 chronic atticoantral disease 10.5 TNF MUC5AC
37 ventilation pneumonitis 10.5 CRP CD4
38 syphilitic meningitis 10.5 CRP CD4
39 bicipital tenosynovitis 10.5 PRTN3 CRP
40 mikulicz disease 10.5 CRP CD4 CCR6
41 pericardial tuberculosis 10.5 TNF CRP CD4
42 orbital granuloma 10.5 PRTN3 CRP
43 optic papillitis 10.5 TNF CRP CD4
44 lymph node tuberculosis 10.5 TNF CRP CD4
45 granulomatous dermatitis 10.5 TNF CRP CD4
46 nocardiosis 10.5 TNF CRP CD4
47 granulomatous hepatitis 10.5 TNF CRP CD4
48 opportunistic bacterial infectious disease 10.5 TNF CRP CD4
49 intestinal tuberculosis 10.5 TNF CRP CD4
50 toxic megacolon 10.5 TNF CRP CCR6

Graphical network of the top 20 diseases related to Middle Ear Disease:



Diseases related to Middle Ear Disease

Symptoms & Phenotypes for Middle Ear Disease

MGI Mouse Phenotypes related to Middle Ear Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 CCR6 CD4 CRP DHRS2 DNAH11 DNAH5
2 immune system MP:0005387 10.06 CCR6 CD4 CRP DNAH11 DNAH5 DNAI1
3 digestive/alimentary MP:0005381 9.86 CD4 DNAH11 DNAH5 FBXO11 IL6 MUC5AC
4 respiratory system MP:0005388 9.56 DNAH11 DNAH5 DNAI1 IL6 MUC5B SIGLEC5
5 hematopoietic system MP:0005397 9.47 CCR6 CD4 DNAH11 DNAH5 DNAI1 FBXO11

Drugs & Therapeutics for Middle Ear Disease

Drugs for Middle Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racephedrine Approved, Experimental Phase 1 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
2
Phenylephrine Approved Phase 1 59-42-7 6041
3
Histamine Approved, Investigational Phase 1 51-45-6 774
4
Oxymetazoline Approved, Investigational Phase 1 1491-59-4 4636
5 Cardiotonic Agents Phase 1
6 Neurotransmitter Agents Phase 1
7 Central Nervous System Stimulants Phase 1
8 Bronchodilator Agents Phase 1
9 Adrenergic alpha-Agonists Phase 1
10 Adrenergic Agonists Phase 1
11 Adrenergic Agents Phase 1
12 Anti-Asthmatic Agents Phase 1
13 Vasoconstrictor Agents Phase 1
14 Pharmaceutical Solutions Phase 1
15
Histamine phosphate Phase 1 51-74-1 134614
16 Respiratory System Agents Phase 1
17 Mydriatics Phase 1
18 Sympathomimetics Phase 1
19 Protective Agents Phase 1
20 Nasal Decongestants Phase 1
21 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Middle Ear Pressure Regulation in Health and Disease -- Gas Supply, Demand and Middle Ear Gas Balance -- Specific Aim 2 Completed NCT01925729 Phase 1 pseudoephedrine;Oxymetazoline
2 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417
3 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
4 The Effect of Total Compression Time and Rate (Slope) of Compression on Incidence of Symptomatic Eustachian Tube Dysfunction and Middle Ear Barotrauma: A Phase II Prospective Study. Completed NCT04776967
5 Messung Der Beweglichkeit Der Gehörknöchelchenkette während Einer Ohroperation. ("Objective Measurements of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively") Completed NCT02554422
6 Ph.D.-Project: Eustachian Tube Dysfunction: Causes, Diagnosis, Treatment, and Prognosis Recruiting NCT05055115
7 Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts Recruiting NCT03297736
8 The Effect of Rate (Slope) of Compression on the Incidence of Symptomatic Eustachian Tube Dysfunction and Middle Ear Barotrauma: a Phase III Prospective Study. Recruiting NCT04804098
9 Optical Coherence Tomography of the Middle Ear Using Ossiview Recruiting NCT05085379
10 Otitis Media Diagnosis and Treatment: Coherent Optical Detection of Middle Ear Disease Recruiting NCT05353569

Search NIH Clinical Center for Middle Ear Disease

Genetic Tests for Middle Ear Disease

Anatomical Context for Middle Ear Disease

Organs/tissues related to Middle Ear Disease:

MalaCards : Eye, Bone, Brain, Cortex, T Cells, Thyroid, Lung

Publications for Middle Ear Disease

Articles related to Middle Ear Disease:

(show top 50) (show all 1094)
# Title Authors PMID Year
1
Diagnostic and management plan concordance across advanced audiologists, paediatric audiologists and non-specialist ENT doctors. 62
36384388 2022
2
Culturally safe speech-language supports for First Nations children: Achieving Sustainable Development Goals 3, 4, 8 and 10. 62
36412077 2022
3
Factors affecting clinic attendance for children referred with middle ear conditions. 62
36424855 2022
4
The reliability of video otoscopy recordings and still images in the asynchronous diagnosis of middle-ear disease. 62
34596478 2022
5
Ear and hearing health in Aboriginal and Torres Strait Islander people aged 15 years and older: A scoping review. 62
36260709 2022
6
Postmastoidectomy Hyperacusis Syndrome: Clinical Features and Treatment. 62
36047684 2022
7
Hearing Results in Patients With No Ossicular Chain Reconstruction and Factors Influencing the Outcome. 62
36047689 2022
8
Evaluating the inclusion of tympanometry in population-based surveys of hearing loss. 62
35606901 2022
9
Characterization of Otolaryngology Referrals among Pacific Islanders in the Commonwealth of the Northern Mariana Islands. 62
36118152 2022
10
Morphological and pathological changes of Eustachian tube mucosa in an animal model of eosinophilic otitis media. 62
33176987 2022
11
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Honey, Tyndallized Lactobacillus Acidophilus and Casei to Fight Upper Respiratory Tract Infection and Otitis Media. 62
36011184 2022
12
Endoscopic Cartilage Butterfly Tympanoplasty: A Two-Handed Technique with Endoscope Holder. 62
36032843 2022
13
Environmental Factors for Hearing Loss and Middle Ear Disease in Alaska Native Children and Adolescents: A Cross-Sectional Analysis from a Cluster Randomized Trial. 62
35998103 2022
14
Audiometric Outcomes Comparing Endoscopic Versus Microscopic Ossiculoplasty. 62
35802898 2022
15
The Relationship between the M1/M2 Macrophage Polarization and the Degree of Ossicular Erosion in Human Acquired Cholesteatoma: An Immunohistochemical Study. 62
36013064 2022
16
Otalgia and Facial Nerve Palsy: Common Symptoms Revealing the Uncommon Pathology of Middle Ear Lymphoma. 62
35591894 2022
17
Persisting variance in middle ear ventilation tube insertion in Auckland children: why ethnic disparity continues. 62
35728207 2022
18
Transoral ventral tympanic bulla osteotomy in cats: 13 cases (2016-2019). 62
35358062 2022
19
Congenital Anomalies of the Ossicular Chain: Surgical and Audiological Outcomes. 62
34116598 2022
20
gom1 Mutant Mice as a Model of Otitis Media. 62
35118601 2022
21
Smartphone-Enabled versus Conventional Otoscopy in Detecting Middle Ear Disease: A Meta-Analysis. 62
35454020 2022
22
Adenoidectomy for middle ear disease in cleft palate children: a systematic review. 62
34453572 2022
23
Association between habitual snoring, middle ear disease, and speech problems in young children with non-syndromic cleft palate anomalies. 62
34364736 2022
24
Nitric Oxide Is Locally Produced in the Human Middle Ear and Is Reduced by Acquired Cholesteatoma. 62
34699401 2022
25
Leveraging Open Electronic Health Record Data and Environmental Exposures Data to Derive Insights Into Rare Pulmonary Disease. 62
35837616 2022
26
Ear microbiota and middle ear disease: a longitudinal pilot study of Aboriginal children in a remote south Australian setting. 62
35026986 2022
27
High-Throughput Sequencing Investigation of Bacterial Diversity in Chronic Suppurative Otitis Media and Middle Ear Cholesteatoma. 62
36193141 2022
28
[Mastoid cavity obliteration with allogenic and autologous material]. 62
33946124 2022
29
Preoperative prediction by artificial intelligence for mastoid extension in pars flaccida cholesteatoma using temporal bone high-resolution computed tomography: A retrospective study. 62
36190937 2022
30
Long-Term Effects of Metal-on-Metal Cobalt-Chromium-Containing Prostheses Used in Total Knee Arthroplasty on Hearing and Tinnitus. 62
35990291 2022
31
Risk factors for Australian school-age children in socio-economically disadvantaged populations not passing ear and hearing screening. 62
34873613 2021
32
Cell sheet transplantation prevents inflammatory adhesions: A new treatment for adhesive otitis media. 62
34805451 2021
33
[Analysis of spatial location of the malleus in patients with chronic otitis media based on 10 μm otology CT]. 62
34905886 2021
34
Subannular Tubes in Children With Cleft Palate. 62
33535818 2021
35
[Study on the relationship between the morphology of the isthmus of the vestibular aqueduct and Meniere's disease based on 10 μm otology CT]. 62
34905888 2021
36
Middle ear disease requiring myringotomy in the first two years after tracheotomy in the pediatric population. 62
34411868 2021
37
Respiratory viruses in the healthy middle ear and middle ear with otitis media with effusion. 62
34160830 2021
38
Cystic fibrosis mutation classes in pediatric otitis media - Fickle or faulty? 62
33957545 2021
39
Complete restoration of congenital conductive hearing loss by staged surgery: A case report. 62
34904101 2021
40
Unlearning the ABCs of Tympanometry. 62
33687296 2021
41
Seronegative granulomatosis with polyangiitis presenting as an acute skull base osteomyelitis with multiple cranial neuropathies. 62
34691387 2021
42
Characteristics of health-related quality of life in different types of chronic middle ear disease. 62
33242111 2021
43
Identification of critical windows in early development of human upper respiratory tract and middle ear disease. 62
33586870 2021
44
An Incidental Chorda Tympani Schwannoma Identified During Middle Ear Surgery. 62
34713010 2021
45
Disability from chronic ear disease in Nepal assessed using the World Health Organization Disability Assessment Schedule 2.0 instrument. 62
34496988 2021
46
Craniocervical fractures management in case of craniocervical pneumatization: case report and review of the literature. 62
33389118 2021
47
Aeration of the Human Prussak's Space: A 3D Synchrotron Imaging Study. 62
33859141 2021
48
Prevalence of Otological Disease in Turner Syndrome: A Systematic Review. 62
33625195 2021
49
Nasal autoinflation devices for middle ear disease in cleft palate children: are they effective? 62
34533540 2021
50
Rising Resonance Frequency Is the Sole Sign of Early Middle Ear Disease in Children With Adenoid Hypertrophy. 62
33625192 2021

Variations for Middle Ear Disease

Expression for Middle Ear Disease

Search GEO for disease gene expression data for Middle Ear Disease.

Pathways for Middle Ear Disease

Pathways related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 TNF TLR2 SIGLEC5 SERPINA3 PRTN3 MUC5B
2
Show member pathways
13.36 TNF TLR2 IL6 IL1B CXCL8 CD4
3
Show member pathways
12.8 TNF TLR2 IL6 IL1B CXCL8
4
Show member pathways
12.47 TNF TLR2 IL6 IL1B CXCL8
5
Show member pathways
12.38 TNF TLR2 IL6 IL1B CXCL8
6
Show member pathways
12.27 TNF IL6 IL1B CXCL8
7
Show member pathways
12.27 TLR2 PRTN3 CD4 CCR6
8
Show member pathways
12.25 TNF TLR2 MUC5B MUC5AC IL6 IL1B
9 12.13 TNF IL6 IL1B CXCL8
10
Show member pathways
12.02 CXCL8 IL6 MUC5AC MUC5B TLR2 TNF
11 11.97 CXCL8 IL1B IL6 TNF
12 11.93 TNF IL6 IL1B CXCL8
13
Show member pathways
11.88 TNF TLR2 IL6 IL1B CD4
14
Show member pathways
11.83 CD4 IL1B IL6 TLR2
15 11.76 TNF IL1B CD4 CCR6
16
Show member pathways
11.74 IL6 CXCL8 CRP CD4
17 11.71 TNF IL6 IL1B CXCL8
18 11.69 TNF IL6 CRP
19 11.69 TNF IL6 IL1B CD4
20 11.67 IL6 IL1B CD4
21 11.62 TNF IL6 CXCL8
22 11.62 TNF IL6 IL1B
23
Show member pathways
11.61 TNF IL6 IL1B CXCL8
24
Show member pathways
11.59 TNF TLR2 IL6
25 11.52 CXCL8 IL6 TNF
26 11.49 TNF TLR2 IL1B
27 11.47 TNF IL6 IL1B CXCL8
28 11.46 TNF IL6 IL1B
29 11.34 TNF IL6 IL1B
30 11.29 TNF IL6 IL1B
31 11.21 TNF IL6 CXCL8
32 11.21 TNF IL6 IL1B CXCL8
33 11.17 CD4 IL1B IL6 TNF
34 11.12 TNF IL6 IL1B CXCL8
35 10.82 TNF MUC5B IL6 IL1B CXCL8
36 10.67 IL6 CXCL8
37 10.54 TNF IL6 CXCL8 CRP
38
Show member pathways
10.33 TNF IL6 CXCL8

GO Terms for Middle Ear Disease

Cellular components related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TNF SERPINA3 PRTN3 MUC5B MUC5AC IL6
2 9+0 motile cilium GO:0097728 9.56 DNAH5 DNAH11
3 dynein complex GO:0030286 9.55 DNAI1 DNAH5 DNAH11
4 9+2 motile cilium GO:0097729 9.1 DNAI1 DNAH5 DNAH11

Biological processes related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell population proliferation GO:0008285 10.31 TNF TLR2 IL6 IL1B DHRS2 CXCL8
2 inflammatory response GO:0006954 10.25 TNF TLR2 SERPINA3 IL6 IL1B CXCL8
3 immune response GO:0006955 10.17 TNF TLR2 IL6 IL1B CXCL8 CD4
4 positive regulation of interleukin-6 production GO:0032755 10.15 IL1B IL6 TLR2 TNF
5 calcium-mediated signaling GO:0019722 10.13 TNF CXCL8 CD4 CCR6
6 lipopolysaccharide-mediated signaling pathway GO:0031663 10.06 TNF TLR2 IL1B
7 positive regulation of interleukin-8 production GO:0032757 10.06 IL1B IL6 TLR2 TNF
8 acute-phase response GO:0006953 10.05 SERPINA3 IL6 CRP
9 defense response to Gram-positive bacterium GO:0050830 10.02 TNF TLR2 IL6 IL1B CRP
10 negative regulation of neurogenesis GO:0050768 9.99 TNF IL6 IL1B
11 cilium movement GO:0003341 9.97 DNAH11 DNAH5 DNAI1 RSPH4A
12 positive regulation of glial cell proliferation GO:0060252 9.95 TNF IL6 IL1B
13 positive regulation of fever generation GO:0031622 9.89 TNF IL1B
14 epithelial cilium movement involved in extracellular fluid movement GO:0003351 9.89 DNAI1 DNAH5 DNAH11
15 sequestering of triglyceride GO:0030730 9.86 TNF IL1B
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.84 TNF IL1B
17 positive regulation of chemokine production GO:0032722 9.8 TNF TLR2 IL6 IL1B
18 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF IL6 IL1B
19 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP
20 vascular endothelial growth factor production GO:0010573 9.1 TNF IL6 IL1B

Sources for Middle Ear Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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