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MCID: MDD010
MIFTS: 50

Middle Ear Disease

Categories: Ear diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Middle Ear Disease

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MalaCards integrated aliases for Middle Ear Disease:

Name: Middle Ear Disease 12 15
Abnormality of the Middle Ear 29
Disorder of Middle Ear 73

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5100
NCIt 50 C27065
UMLS 73 C0271428
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Summaries for Middle Ear Disease

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MalaCards based summary : Middle Ear Disease, also known as abnormality of the middle ear, is related to auditory system disease and vasculitis. An important gene associated with Middle Ear Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Iron and Edetic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and thyroid, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Middle Ear Disease

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Diseases related to Middle Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 auditory system disease 32.3 RTEL1 SLC29A3 TLR9
2 vasculitis 29.2 CD40LG CD79A PRTN3 TNF
3 otitis media 26.5 A2ML1 CD40LG CD79A CXCL8 FBXO11 IL1B
4 adhesive otitis media 11.4
5 mastoiditis 11.2
6 selective igg deficiency disease 11.0 CD40LG CD79A
7 c1q nephropathy 11.0 CD40LG CD79A
8 meningovascular neurosyphilis 11.0 CD40LG CD79A
9 alpha chain disease 11.0 CD40LG CD79A
10 brill-zinsser disease 11.0 CD40LG CD79A
11 cork-handlers' disease 11.0 CD40LG CD79A
12 salpingo-oophoritis 11.0 CD40LG CD79A
13 early yaws 11.0 CD40LG CD79A
14 ventilation pneumonitis 11.0 CD40LG CD79A
15 chronic interstitial cystitis 11.0 CD40LG CD79A
16 axillary adenitis 11.0 CD40LG CD79A
17 cryofibrinogenemia 11.0 CD40LG CD79A
18 trichostrongyloidiasis 10.9 CD40LG CD79A
19 subacute bacterial endocarditis 10.9 CD40LG CD79A
20 heterophyiasis 10.9 CD40LG CD79A
21 immunoglobulin g deficiency 10.9 CD40LG CD79A
22 encapsulated thymoma 10.9 CD79A MUC5B
23 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
24 chronic follicular conjunctivitis 10.9 CD79A IL1B
25 hyperglobulinemic purpura 10.9 CD40LG CD79A
26 gastroduodenitis 10.9 CD40LG CD79A
27 bacterial conjunctivitis 10.9 CD40LG CD79A
28 heavy chain disease 10.9 CD40LG CD79A
29 ocular toxoplasmosis 10.9 CD40LG CD79A TLR9
30 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A SLC29A3
31 ophthalmia neonatorum 10.8 CD40LG CD79A
32 autoimmune disease of urogenital tract 10.8 CD40LG CD79A TLR9
33 meningoencephalitis 10.8 CD40LG CD79A TLR9
34 mature b-cell neoplasm 10.8 CD40LG CD79A TLR9
35 b cell deficiency 10.8 CD40LG CD79A TLR9
36 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
37 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
38 parotid disease 10.8 CD40LG CD79A
39 staphylococcal toxic shock syndrome 10.8 IL1B TNF
40 cerebral arteritis 10.8 CD40LG CD79A
41 autoimmune myocarditis 10.7 IL1B TNF
42 acute salpingitis 10.7 CD40LG CD79A TNF
43 monoclonal gammopathy of uncertain significance 10.7 CD40LG CD79A TNF
44 pneumocystosis 10.7 CD40LG CD79A TNF
45 pustulosis palmaris et plantaris 10.7 CD40LG CD79A TNF
46 mycobacterium chelonae 10.7 CXCL8 TLR2
47 lymph node disease 10.7 CD40LG CD79A TNF
48 cogan syndrome 10.7 CD40LG CD79A TNF
49 leukocyte disease 10.7 CD40LG TLR9 TNF
50 selective immunoglobulin deficiency disease 10.7 CD40LG CD79A

Graphical network of the top 20 diseases related to Middle Ear Disease:



Diseases related to Middle Ear Disease
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Symptoms & Phenotypes for Middle Ear Disease

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MGI Mouse Phenotypes related to Middle Ear Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 MCAT TLR4 TLR9 MUC5B PRTN3 TNF
2 hematopoietic system MP:0005397 10 MCAT TLR4 TLR9 MUC5B PRTN3 TNF
3 homeostasis/metabolism MP:0005376 9.93 IL1B MCAT TLR4 MUC5AC TLR9 MUC5B
4 digestive/alimentary MP:0005381 9.87 TLR2 MCAT TLR4 MUC5AC TLR9 TNF
5 immune system MP:0005387 9.77 TLR4 MCAT MUC5AC TLR9 MUC5B TNF
6 neoplasm MP:0002006 9.17 TLR4 TNF RTEL1 CD79A SLC29A3 TLR2
Sources

Drugs & Therapeutics for Middle Ear Disease

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Drugs for Middle Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 3 7439-89-6 23925
2
Edetic Acid Approved, Vet_approved Phase 3 60-00-4, 62-33-9 6049
3
Pentetic acid Approved Phase 3 67-43-6
4 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
5 Vaccines Phase 3
6 Chelating Agents Phase 3
7 Hormone Antagonists Phase 3
8 Hormones Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Anticoagulants Phase 3
11 Antidotes Phase 3
12 Iron Chelating Agents Phase 3
13 Protective Agents Phase 3,Not Applicable
14 Calcium, Dietary Phase 3,Phase 2
15
Calcium Carbonate Approved, Investigational Phase 2 471-34-1
16
Simethicone Approved Phase 2 8050-81-5
17 Dermatologic Agents Phase 2
18 Emollients Phase 2
19
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
20
Menthol Approved Not Applicable 2216-51-5 16666
21
Cocaine Approved, Illicit Not Applicable 50-36-2 5760 446220
22
Ephedrine Approved Not Applicable 299-42-3 9294
23
Pseudoephedrine Approved Not Applicable 90-82-4 7028
24
Phenylephrine Approved Not Applicable 59-42-7 6041
25
Histamine Approved, Investigational Not Applicable 75614-87-8, 51-45-6 774
26
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
27
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
28 tannic acid Approved, Nutraceutical Not Applicable
29
Histamine Phosphate Not Applicable 51-74-1 65513
30 Trichostatin A Not Applicable
31 Respiratory System Agents Not Applicable
32 Adrenergic Agents Not Applicable
33 Central Nervous System Stimulants Not Applicable
34 Adrenergic Agonists Not Applicable
35 Adrenergic alpha-Agonists Not Applicable
36 Mydriatics Not Applicable
37 Nasal Decongestants Not Applicable
38 Neurotransmitter Agents Not Applicable
39 Vasoconstrictor Agents Not Applicable
40 Anti-Asthmatic Agents Not Applicable
41 Peripheral Nervous System Agents Not Applicable
42 Pharmaceutical Solutions Not Applicable
43 Autonomic Agents Not Applicable
44 Bronchodilator Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
2 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers Completed NCT00714064 Phase 3
3 The Effect of Growth Hormone in Very Young Girls With Turner Syndrome Completed NCT00406926 Phase 3 Somatropin
4 Adenoidectomy for Otitis Media in 2-3 Year Old Children Terminated NCT00016497 Phase 3
5 Effect of Simethicone on Eustachian Tube Dysfunction Completed NCT01312038 Phase 2 Simethicone;Placebo
6 Furlow Palatoplasty With Tensor Tenopexy Active, not recruiting NCT01535131 Phase 2
7 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
8 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417
9 Genetics of Middle Ear Disease Completed NCT00422136
10 Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11 Completed NCT00365092 Not Applicable
11 Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction Completed NCT02114762 Not Applicable
12 Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion Completed NCT00393900
13 Novel Imaging of the Eustachian Tube; Patient Study Completed NCT02282540 Not Applicable
14 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults Completed NCT01251432
15 Functional Manifestations of Pressure Changes in the Middle Ear System Completed NCT01932736 Not Applicable
16 Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' Homes Completed NCT00670280 Not Applicable
17 To Evaluate the Incidence of Acute Otitis Media in Children in Five East European Countries Completed NCT01365390
18 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2 Completed NCT00694421
19 Polish Mother and Child Cohort Study (REPRO_PL) - Follow up of the Children. Completed NCT01861548
20 Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts Recruiting NCT03297736 Not Applicable
21 Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction Recruiting NCT01974726 Not Applicable
22 TransMEM Gas Exchange -- Project 1, Aim 2 Recruiting NCT01925729 Not Applicable pseudoephedrine;Oxymetazoline
23 Trans-Middle-Ear Mucosal Gas Exchange Project 1, Specific Aim 1 Recruiting NCT01925482 Not Applicable 6%CO2, 25%O2, balance N2;6% CO2, 0%O2, balance N2;20%CO2, 6%O2, balance N2;0%CO2, 6%O2, balance N2;6% CO2, 6%O2, balance N2;6%CO2, 6%O2, 0%N2, balance argon
24 Eustachian Tube Growth and Development Active, not recruiting NCT00422929
25 Middle Ear Pressure Disregulation in Cleft Palate Patients Active, not recruiting NCT00423072
26 Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population Active, not recruiting NCT03541434
27 Eustachian Tube Function and Myringoplasty/Tympanoplasty Terminated NCT01766856

Search NIH Clinical Center for Middle Ear Disease

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Genetic Tests for Middle Ear Disease

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Genetic tests related to Middle Ear Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Middle Ear 29
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Anatomical Context for Middle Ear Disease

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MalaCards organs/tissues related to Middle Ear Disease:

41
Bone, Testes, Thyroid, Colon, Brain
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Publications for Middle Ear Disease

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Articles related to Middle Ear Disease:

(show top 50) (show all 220)
# Title Authors Year
1
Computed tomographic findings in 205 dogs with clinical signs compatible with middle ear disease: a retrospective study. ( 28994490 )
2018
2
Middle-ear disease in children with cleft palate. ( 29764722 )
2018
3
The Role of the Eustachian Tube in Middle Ear Disease. ( 29794454 )
2018
4
Assessment of vestibular function in patients with chronic middle ear disease using the VHIT and VEMP test. ( 29665318 )
2018
5
Middle ear disease in Danish toddlers attending nursery day-care - Applicability of OM-6, disease specific quality of life and predictors for middle ear symptoms. ( 29859574 )
2018
6
Postoperative Mastoid Aeration Following Canal Wall Up Mastoidectomy according to Preoperative Middle Ear Disease: Analysis of Temporal Bone Computed Tomography Scans. ( 28942628 )
2017
7
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? ( 28474190 )
2017
8
It is prudent to consider use of endoscopic tympanoplasty to treat complicated middle-ear disease. ( 28608240 )
2017
9
Eustachian Tube Function in 6-Year-Old Children with and without a History of Middle Ear Disease. ( 26626132 )
2016
10
Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. ( 27695944 )
2016
11
PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia. ( 26529076 )
2015
12
Computed tomographic features of clinical and subclinical middle ear disease in domestic rabbits (Oryctolagus cuniculus): 88 cases (2007-2014). ( 25587734 )
2015
13
A comparison of systemic inflammatory responses between immunocompetent and immunocompromised patients presenting with otorrhea due to chronic suppurative middle ear disease. ( 25728629 )
2015
14
COMQ-12 scores in adult patients without chronic middle ear disease. ( 25142494 )
2014
15
Long-term hearing deficits after childhood middle ear disease. ( 25127328 )
2014
16
Blind sac closure of the external auditory canal for chronic middle ear disease. ( 24317214 )
2014
17
Extracellular and intracellular melanin in inflammatory middle ear disease. ( 24999501 )
2014
18
Eustachian tube opening measured by sonotubometry is poorer in adults with a history of past middle ear disease. ( 24491807 )
2014
19
Middle Ear Disease and Cochlear Implant Function: A Case Study. ( 26693101 )
2014
20
Household number associated with middle ear disease at an urban Indigenous health service: a cross-sectional study. ( 23711080 )
2013
21
Preoperative assessment of taste function in patients with middle ear disease. ( 22664899 )
2012
22
Conventionally accepted risk factors do not explain higher rates of middle ear disease in remote Indigenous children: an ecological study. ( 23025377 )
2012
23
[Treatment of middle ear disease associated MPO-ANCA]. ( 24163854 )
2012
24
Prevalence of clinical and subclinical middle ear disease in cats undergoing computed tomographic scans of the head. ( 22092494 )
2012
25
Parental smoking and the risk of middle ear disease in children: a systematic review and meta-analysis. ( 21893640 )
2012
26
Is it the middle ear disease or the reconstruction material that determines the functional outcome in ossicular chain reconstruction? ( 22429941 )
2012
27
Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease. ( 21251776 )
2011
28
Expansile, inflammatory middle ear disease causing nasopharyngeal obstruction in a cat. ( 21439877 )
2011
29
Altered Toll- and Nod-like receptor expression in human middle ear mucosa from patients with chronic middle ear disease. ( 21704072 )
2011
30
Low prevalence of middle ear disease in cystic fibrosis patients. ( 21234508 )
2011
31
Eustachian tube function in adults without middle ear disease. ( 21585150 )
2011
32
Growth hormone treatment does not affect incidences of middle ear disease or hearing loss in infants and toddlers with Turner syndrome. ( 20424424 )
2010
33
Factors associated with developing cholesteatoma: a study of 45,980 children with middle ear disease. ( 20058316 )
2010
34
Middle ear disease in children with cleft palate: protocols for management. ( 19091429 )
2009
35
Middle ear disease in Aboriginal children in Perth: analysis of hearing screening data, 1998-2004. ( 19450214 )
2009
36
Chorda tympani in chronic inflammatory middle ear disease. ( 19716032 )
2009
37
Aetiological significance of middle-ear disease in schizophrenia. ( 19118337 )
2009
38
Chorda tympani in chronic inflammatory middle ear disease. ( 19393411 )
2009
39
Prevalence of clinical abnormalities in cats found to have nonneoplastic middle ear disease at necropsy: 59 cases (1991-2007). ( 19793014 )
2009
40
Eosinophilic otitis media: a new middle ear disease entity. ( 18940145 )
2008
41
Middle-ear disease and schizophrenia: case-control study. ( 18757975 )
2008
42
No negative outcomes of childhood middle ear disease in adulthood. ( 17334307 )
2007
43
Assessment of middle ear disease in the dog: a comparison of diagnostic imaging modalities. ( 17381763 )
2007
44
Comparative performance of radiography and computed tomography in the diagnosis of middle ear disease in 31 dogs. ( 16429984 )
2006
45
Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? ( 16428192 )
2006
46
Consultations for middle ear disease, antibiotic prescribing and risk factors for reattendance: a case-linked cohort study. ( 16536956 )
2006
47
Microbiology of middle ear effusions from 292 patients undergoing tympanostomy tube placement for middle ear disease. ( 15885332 )
2005
48
The use of tympanometry and pneumatic otoscopy for predicting middle ear disease. ( 16180966 )
2005
49
Medical management of middle ear disease in children less than 2 years of age with sensorineural hearing loss. ( 16076419 )
2005
50
Aboriginal perspective on middle ear disease in the arid zone of Western Australia. ( 15151578 )
2004
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Variations for Middle Ear Disease

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Expression for Middle Ear Disease

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Search GEO for disease gene expression data for Middle Ear Disease.
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Pathways for Middle Ear Disease

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Pathways related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.93 A1BG CD40LG CD79A CXCL8 DEFB4B IL1B
2
Akt Signaling 64
Show member pathways
 13.36 CD40LG CXCL8 IL1B TLR2 TLR4 TLR9
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.98 CXCL8 IL1B TLR2 TLR4 TLR9 TNF
4
IL-2 Pathway 64
Show member pathways
 12.77 CD79A IL1B TLR2 TLR4 TLR9 TNF
5
Influenza A 37
Show member pathways
 12.76 CXCL8 IL1B TLR2 TLR4 TLR9 TNF
6
NF-KappaB Family Pathway 64
Show member pathways
 12.69 CD40LG IL1B TLR2 TLR4 TLR9 TNF
7
NF-kappaB Signaling 4
12.52 CD40LG CD79A IL1B TLR2 TLR9 TNF
8
Th17 cell differentiation 37
Show member pathways
 12.39 IL1B TLR2 TLR4 TNF
9
TRAF Pathway 64
Show member pathways
 12.38 CD40LG IL1B TLR2 TLR4 TLR9 TNF
10
Defensins 66
Show member pathways
 12.31 DEFB4B PDZD11 PRTN3 TLR2
11
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.25 CXCL8 TLR2 TLR4 TLR9 TNF
12
Toll Comparative Pathway 64
Show member pathways
 12.24 CXCL8 IL1B TLR4 TNF
13
Th1 Differentiation Pathway 65
Show member pathways
 12.24 IL1B TLR2 TLR4 TLR9 TNF
14
Toxoplasmosis 37
Show member pathways
 12.23 CD40LG IL1B TLR2 TLR4 TNF
15
Tuberculosis 37
12.2 IL1B TLR2 TLR4 TLR9 TNF
16
Colorectal Cancer Metastasis 64
12.15 TLR2 TLR4 TLR9 TNF
17
IL-1 Family Signaling Pathways 65
Show member pathways
 12.13 CXCL8 IL1B MUC5AC MUC5B TLR2 TNF
18
Bacterial infections in CF airways 22
Show member pathways
 12.02 CXCL8 IL1B TLR2 TLR4 TLR9 TNF
19
MAPK Pathway 72
Show member pathways
 12.01 IL1B TLR2 TLR4 TLR9
20
Spinal Cord Injury 1
11.99 CXCL8 IL1B TLR4 TNF
21
Amoebiasis 37
11.86 CXCL8 IL1B TLR2 TLR4 TNF
22
AGE-RAGE signaling pathway in diabetic complications 37
11.85 CXCL8 IL1B TNF
23
NF-kappa B signaling pathway 37
11.83 CD40LG CXCL8 IL1B TLR4 TNF
24
IL-17 Family Signaling Pathways 65
Show member pathways
 11.83 CXCL8 DEFB4B IL1B MUC5AC MUC5B TLR2
25
Rheumatoid arthritis 37
11.79 CXCL8 IL1B TLR2 TLR4 TNF
26
Salmonella infection (KEGG) 37
11.78 CXCL8 IL1B TLR4
27
Phagocytosis of Microbes 64
11.77 TLR2 TLR4 TLR9
28
Pertussis 37
11.77 CXCL8 IL1B TLR4 TNF
29
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 CD40LG CXCL8 TNF
30
Dendritic Cells Developmental Lineage Pathway 65
11.7 IL1B TLR9 TNF
31
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.64 CD40LG CXCL8 IL1B TNF
32
Interleukin-10 signaling 66
11.5 CXCL8 IL1B TNF
33
MSP-RON Signaling 64
11.49 IL1B TLR2 TLR4 TNF
34
Lung fibrosis 1
11.45 CXCL8 IL1B MUC5B RTEL1 TNF
35
African trypanosomiasis 37
11.35 IL1B TLR9 TNF
36
IL-10 Pathway 64
11.34 IL1B TLR4 TNF
37
Legionellosis 37
11.29 CXCL8 IL1B TLR2 TLR4 TNF
38
Malaria 37
10.86 CD40LG CXCL8 IL1B TLR2 TLR4 TLR9
Sources

GO Terms for Middle Ear Disease

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Cellular components related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 A1BG A2ML1 CD40LG CXCL8 DEFB4B IL1B
2 external side of plasma membrane GO:0009897 9.56 CD40LG CD79A TLR4 TNF
3 membrane raft GO:0045121 9.46 CD79A PRTN3 TLR2 TNF
4 extracellular space GO:0005615 9.36 A1BG A2ML1 CD40LG CXCL8 DEFB4B IL1B

Biological processes related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.98 DEFB4B TLR4 TLR9 TNF
2 response to lipopolysaccharide GO:0032496 9.96 CXCL8 IL1B TLR2 TLR4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 IL1B TLR4 TLR9 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.87 DEFB4B TLR2 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.87 DEFB4B TLR4 TLR9
6 positive regulation of inflammatory response GO:0050729 9.85 TLR2 TLR4 TLR9
7 positive regulation of JNK cascade GO:0046330 9.85 IL1B TLR4 TLR9 TNF
8 antimicrobial humoral response GO:0019730 9.83 DEFB4B PDZD11 PRTN3
9 positive regulation of tumor necrosis factor production GO:0032760 9.81 TLR2 TLR4 TLR9
10 toll-like receptor signaling pathway GO:0002224 9.8 TLR2 TLR4 TLR9
11 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B TLR4 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 IL1B TLR4 TNF
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.75 TLR2 TLR4 TLR9
14 negative regulation of interleukin-6 production GO:0032715 9.74 TLR4 TLR9 TNF
15 positive regulation of interferon-beta production GO:0032728 9.73 TLR2 TLR4 TLR9
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
17 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CD40LG IL1B TLR2 TLR4 TLR9 TNF
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR4 TLR9
19 positive regulation of interleukin-12 production GO:0032735 9.71 CD40LG TLR2 TLR4 TLR9
20 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 TLR2 TLR9
21 negative regulation of phagocytosis GO:0050765 9.69 PRTN3 TLR2
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 IL1B TNF
23 I-kappaB phosphorylation GO:0007252 9.69 TLR2 TLR4 TLR9
24 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
25 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B TLR9
26 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
28 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
29 regulation of cytokine secretion GO:0050707 9.67 TLR2 TLR4 TLR9
30 positive regulation of interleukin-10 production GO:0032733 9.67 CD40LG TLR2 TLR4 TLR9
31 positive regulation of interferon-beta biosynthetic process GO:0045359 9.66 TLR4 TLR9
32 positive regulation of fever generation GO:0031622 9.64 IL1B TNF
33 regulation of immunoglobulin secretion GO:0051023 9.64 CD40LG TNF
34 positive regulation of chemokine production GO:0032722 9.62 TLR2 TLR4 TLR9 TNF
35 positive regulation of toll-like receptor signaling pathway GO:0034123 9.61 TLR2 TLR9
36 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
37 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
38 positive regulation of interleukin-18 production GO:0032741 9.59 TLR2 TLR9
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
40 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B TLR2 TLR4 TLR9 TNF
41 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.35 IL1B TLR2 TLR4 TLR9 TNF
42 positive regulation of interleukin-8 production GO:0032757 9.02 IL1B TLR2 TLR4 TLR9 TNF
43 positive regulation of gene expression GO:0010628 10.05 IL1B TLR2 TLR4 TLR9 TNF
44 immune response GO:0006955 10.02 CD40LG CXCL8 DEFB4B IL1B TLR2 TLR4
45 inflammatory response GO:0006954 10 CD40LG CXCL8 IL1B TLR2 TLR4 TLR9

Molecular functions related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CD40LG CXCL8 IL1B TNF
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4
Sources

Sources for Middle Ear Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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