MCID: MDD010
MIFTS: 50

Middle Ear Disease

Categories: Ear diseases

Aliases & Classifications for Middle Ear Disease

MalaCards integrated aliases for Middle Ear Disease:

Name: Middle Ear Disease 12 15
Abnormality of the Middle Ear 29
Disorder of Middle Ear 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5100
NCIt 50 C27065
SNOMED-CT 68 68996008
UMLS 73 C0271428

Summaries for Middle Ear Disease

MalaCards based summary : Middle Ear Disease, also known as abnormality of the middle ear, is related to auditory system disease and otitis media. An important gene associated with Middle Ear Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Edetic Acid and Pentetic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Middle Ear Disease

Diseases related to Middle Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 auditory system disease 30.8 A1BG RTEL1 SLC29A3 TLR9
2 otitis media 29.5 A2ML1 CXCL8 FBXO11 IL1B IL6 MUC5AC
3 adhesive otitis media 11.6
4 mastoiditis 11.3
5 staphylococcal toxic shock syndrome 10.3 TNF IL1B
6 eye lymphoma 10.3 TLR9 IL6
7 tungiasis 10.3 TNF CXCL8
8 cleft palate, isolated 10.3
9 paraneoplastic syndromes 10.3 IL6 IL1B
10 mycobacterium chelonae 10.3 TLR2 CXCL8
11 mycobacterium kansasii 10.3 TLR2 CXCL8
12 mycobacterium marinum 10.3 TLR2 CXCL8
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 TNF IL6
14 critical limb ischemia 10.3 TNF IL6
15 leukomalacia 10.3 TNF IL6
16 scorpion envenomation 10.3 TNF IL6
17 rheumatic disease 10.3 TNF TLR9 IL1B
18 acute transverse myelitis 10.3 IL6 CXCL8
19 bile duct mucoepidermoid carcinoma 10.3 MUC5B MUC5AC
20 idiopathic interstitial pneumonia 10.3 TLR9 MUC5B CXCL8
21 viral hepatitis 10.3 TNF TLR9 TLR2
22 pulmonary tuberculosis 10.3 TNF TLR9 TLR2
23 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
24 duodenal ulcer 10.2 TNF IL1B CXCL8
25 allergic contact dermatitis 10.2 TNF IL1B CXCL8
26 atrophic gastritis 10.2 TNF IL1B CXCL8
27 autoimmune disease of musculoskeletal system 10.2 TNF TLR9 IL6
28 peripheral nervous system disease 10.2 TNF TLR9 IL6
29 keratoconjunctivitis 10.2 TNF TLR9 CXCL8
30 leukocyte disease 10.2 TNF TLR9 IL6
31 graft-versus-host disease 10.2 TNF IL6 IL1B
32 cerebral palsy 10.2 TNF IL6 IL1B
33 exudative glomerulonephritis 10.2 CXCL8 IL1B TNF
34 acquired immunodeficiency syndrome 10.2 TNF IL6 IL1B
35 juvenile rheumatoid arthritis 10.2 TNF IL6 IL1B
36 chronic fatigue syndrome 10.2 TNF IL6 IL1B
37 congenital cytomegalovirus 10.2 IL1B TLR2 TNF
38 posterior scleritis 10.2 TNF PRTN3
39 esophagitis 10.2 IL6 IL1B CXCL8
40 endometriosis 10.2 IL6 IL1B CXCL8
41 extrinsic allergic alveolitis 10.2 IL6 IL1B CXCL8
42 opisthorchiasis 10.2 CXCL8 IL1B TNF
43 prosthetic joint infection 10.2 IL1B TLR2 TLR4
44 crohn's colitis 10.2 CXCL8 IL1B TNF
45 alcoholic hepatitis 10.2 TNF IL6 CXCL8
46 obstructive jaundice 10.2 TNF IL6 CXCL8
47 primary systemic mycosis 10.2 IL1B TLR2 TNF
48 myositis fibrosa 10.2 TLR2 TLR4 TLR9
49 atherosclerosis susceptibility 10.2 TNF TLR4 IL6
50 trench fever 10.2 TLR2 TLR4 TNF

Graphical network of the top 20 diseases related to Middle Ear Disease:



Diseases related to Middle Ear Disease

Symptoms & Phenotypes for Middle Ear Disease

MGI Mouse Phenotypes related to Middle Ear Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 AREG FGF7 IL1B IL6 MCAT MUC5B
2 homeostasis/metabolism MP:0005376 10.07 AREG FBXO11 FGF7 IL1B IL6 MCAT
3 digestive/alimentary MP:0005381 10.02 AREG FBXO11 IL6 MCAT MUC5AC TLR2
4 immune system MP:0005387 10 AREG FBXO11 FGF7 IL1B IL6 MCAT
5 integument MP:0010771 9.61 AREG FBXO11 FGF7 IL1B IL6 MCAT
6 neoplasm MP:0002006 9.17 IL1B IL6 RTEL1 SLC29A3 TLR2 TLR4

Drugs & Therapeutics for Middle Ear Disease

Drugs for Middle Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Edetic Acid Approved, Vet_approved Phase 3 62-33-9, 60-00-4 6049
2
Pentetic acid Approved Phase 3 67-43-6
3
Iron Approved Phase 3 7439-89-6 23925
4 Immunologic Factors Phase 3
5 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
6 Vaccines Phase 3
7 Anticoagulants Phase 3
8 Calcium, Dietary Phase 3,Phase 2
9 Chelating Agents Phase 3
10 Protective Agents Phase 3,Not Applicable
11 Iron Chelating Agents Phase 3
12 Antidotes Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Hormones Phase 3
15 Hormone Antagonists Phase 3
16
Calcium Carbonate Approved, Investigational Phase 2 471-34-1
17
Simethicone Approved Phase 2 8050-81-5
18 Emollients Phase 2
19 Dermatologic Agents Phase 2
20
Phenylephrine Approved Not Applicable 59-42-7 6041
21
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
22
Cocaine Approved, Illicit Not Applicable 50-36-2 5760 446220
23
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
24
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
25 tannic acid Approved Not Applicable
26
Pseudoephedrine Approved Not Applicable 90-82-4 7028
27
Histamine Approved, Investigational Not Applicable 51-45-6, 75614-87-8 774
28
Ephedrine Approved Not Applicable 299-42-3 9294
29 Trichostatin A Not Applicable
30 Neurotransmitter Agents Not Applicable
31 Mydriatics Not Applicable
32 Adrenergic Agents Not Applicable
33 Vasoconstrictor Agents Not Applicable
34 Central Nervous System Stimulants Not Applicable
35 Cardiotonic Agents Not Applicable
36 Respiratory System Agents Not Applicable
37 Sympathomimetics Not Applicable
38 Anti-Asthmatic Agents Not Applicable
39
Histamine Phosphate Not Applicable 51-74-1 65513
40 Bronchodilator Agents Not Applicable
41 Peripheral Nervous System Agents Not Applicable
42 Pharmaceutical Solutions Not Applicable
43 Adrenergic alpha-Agonists Not Applicable
44 Adrenergic Agonists Not Applicable
45 Autonomic Agents Not Applicable
46 Nasal Decongestants Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
2 PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers Completed NCT00714064 Phase 3
3 The Effect of Growth Hormone in Very Young Girls With Turner Syndrome Completed NCT00406926 Phase 3 Somatropin
4 Adenoidectomy for Otitis Media in 2-3 Year Old Children Terminated NCT00016497 Phase 3
5 Effect of Simethicone on Eustachian Tube Dysfunction Completed NCT01312038 Phase 2 Simethicone;Placebo
6 Furlow Palatoplasty With Tensor Tenopexy Active, not recruiting NCT01535131 Phase 2
7 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
8 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417
9 Genetics of Middle Ear Disease Completed NCT00422136
10 Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11 Completed NCT00365092 Not Applicable
11 Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction Completed NCT02114762 Not Applicable
12 Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion Completed NCT00393900
13 Novel Imaging of the Eustachian Tube; Patient Study Completed NCT02282540 Not Applicable
14 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults Completed NCT01251432
15 Functional Manifestations of Pressure Changes in the Middle Ear System Completed NCT01932736 Not Applicable
16 Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' Homes Completed NCT00670280 Not Applicable
17 To Evaluate the Incidence of Acute Otitis Media in Children in Five East European Countries Completed NCT01365390
18 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2 Completed NCT00694421
19 Polish Mother and Child Cohort Study (REPRO_PL) - Follow up of the Children. Completed NCT01861548
20 Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts Recruiting NCT03297736 Not Applicable
21 Gas Supply, Demand and Middle Ear Gas Balance -- Diagnosis of Eustachian Tube Dysfunction Recruiting NCT01974726 Not Applicable
22 TransMEM Gas Exchange -- Project 1, Aim 2 Recruiting NCT01925729 Not Applicable pseudoephedrine;Oxymetazoline
23 Trans-Middle-Ear Mucosal Gas Exchange Project 1, Specific Aim 1 Recruiting NCT01925482 Not Applicable 6%CO2, 25%O2, balance N2;6% CO2, 0%O2, balance N2;20%CO2, 6%O2, balance N2;0%CO2, 6%O2, balance N2;6% CO2, 6%O2, balance N2;6%CO2, 6%O2, 0%N2, balance argon
24 Eustachian Tube Growth and Development Active, not recruiting NCT00422929
25 Middle Ear Pressure Disregulation in Cleft Palate Patients Active, not recruiting NCT00423072
26 Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population Active, not recruiting NCT03541434
27 Eustachian Tube Function and Myringoplasty/Tympanoplasty Terminated NCT01766856

Search NIH Clinical Center for Middle Ear Disease

Genetic Tests for Middle Ear Disease

Genetic tests related to Middle Ear Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Middle Ear 29

Anatomical Context for Middle Ear Disease

MalaCards organs/tissues related to Middle Ear Disease:

41
Brain, Bone, Lung, Heart, Lymph Node, Eye, Spinal Cord

Publications for Middle Ear Disease

Articles related to Middle Ear Disease:

(show top 50) (show all 233)
# Title Authors Year
1
Computed tomographic findings in 205 dogs with clinical signs compatible with middle ear disease: a retrospective study. ( 28994490 )
2018
2
Middle-ear disease in children with cleft palate. ( 29764722 )
2018
3
The Role of the Eustachian Tube in Middle Ear Disease. ( 29794454 )
2018
4
Assessment of vestibular function in patients with chronic middle ear disease using the VHIT and VEMP test. ( 29665318 )
2018
5
In reply to "Commentary to: Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease", by Zhengcai Lou. ( 29423745 )
2018
6
Middle ear disease in Danish toddlers attending nursery day-care - Applicability of OM-6, disease specific quality of life and predictors for middle ear symptoms. ( 29859574 )
2018
7
'Asymptomatic' South Auckland preschool children have significant hearing loss and middle ear disease. ( 30262346 )
2018
8
Postoperative Mastoid Aeration Following Canal Wall Up Mastoidectomy according to Preoperative Middle Ear Disease: Analysis of Temporal Bone Computed Tomography Scans. ( 28942628 )
2017
9
"Commentary to: 'Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease'"? ( 28474190 )
2017
10
In response to Letter to the Editor entitled "It is prudent to consider use of endoscopic tympanoplasty to treat complicated middle ear disease". ( 28653268 )
2017
11
It is prudent to consider use of endoscopic tympanoplasty to treat complicated middle-ear disease. ( 28608240 )
2017
12
Eustachian Tube Function in 6-Year-Old Children with and without a History of Middle Ear Disease. ( 26626132 )
2016
13
Endoscopic and clinical benefits of hyaluronic acid in children with chronic adenoiditis and middle ear disease. ( 27695944 )
2016
14
PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia. ( 26529076 )
2015
15
Computed tomographic features of clinical and subclinical middle ear disease in domestic rabbits (Oryctolagus cuniculus): 88 cases (2007-2014). ( 25587734 )
2015
16
A comparison of systemic inflammatory responses between immunocompetent and immunocompromised patients presenting with otorrhea due to chronic suppurative middle ear disease. ( 25728629 )
2015
17
COMQ-12 scores in adult patients without chronic middle ear disease. ( 25142494 )
2014
18
Long-term hearing deficits after childhood middle ear disease. ( 25127328 )
2014
19
Blind sac closure of the external auditory canal for chronic middle ear disease. ( 24317214 )
2014
20
Extracellular and intracellular melanin in inflammatory middle ear disease. ( 24999501 )
2014
21
Eustachian tube opening measured by sonotubometry is poorer in adults with a history of past middle ear disease. ( 24491807 )
2014
22
Middle Ear Disease and Cochlear Implant Function: A Case Study. ( 26693101 )
2014
23
Household number associated with middle ear disease at an urban Indigenous health service: a cross-sectional study. ( 23711080 )
2013
24
Preoperative assessment of taste function in patients with middle ear disease. ( 22664899 )
2012
25
Conventionally accepted risk factors do not explain higher rates of middle ear disease in remote Indigenous children: an ecological study. ( 23025377 )
2012
26
[Treatment of middle ear disease associated MPO-ANCA]. ( 24163854 )
2012
27
Prevalence of clinical and subclinical middle ear disease in cats undergoing computed tomographic scans of the head. ( 22092494 )
2012
28
Parental smoking and the risk of middle ear disease in children: a systematic review and meta-analysis. ( 21893640 )
2012
29
Is it the middle ear disease or the reconstruction material that determines the functional outcome in ossicular chain reconstruction? ( 22429941 )
2012
30
Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease. ( 21251776 )
2011
31
Expansile, inflammatory middle ear disease causing nasopharyngeal obstruction in a cat. ( 21439877 )
2011
32
Altered Toll- and Nod-like receptor expression in human middle ear mucosa from patients with chronic middle ear disease. ( 21704072 )
2011
33
Low prevalence of middle ear disease in cystic fibrosis patients. ( 21234508 )
2011
34
Eustachian tube function in adults without middle ear disease. ( 21585150 )
2011
35
Growth hormone treatment does not affect incidences of middle ear disease or hearing loss in infants and toddlers with Turner syndrome. ( 20424424 )
2010
36
Factors associated with developing cholesteatoma: a study of 45,980 children with middle ear disease. ( 20058316 )
2010
37
Middle ear disease in children with cleft palate: protocols for management. ( 19091429 )
2009
38
Middle ear disease in Aboriginal children in Perth: analysis of hearing screening data, 1998-2004. ( 19450214 )
2009
39
Chorda tympani in chronic inflammatory middle ear disease. ( 19716032 )
2009
40
Aetiological significance of middle-ear disease in schizophrenia. ( 19118337 )
2009
41
Chorda tympani in chronic inflammatory middle ear disease. ( 19393411 )
2009
42
Prevalence of clinical abnormalities in cats found to have nonneoplastic middle ear disease at necropsy: 59 cases (1991-2007). ( 19793014 )
2009
43
Eosinophilic otitis media: a new middle ear disease entity. ( 18940145 )
2008
44
Middle-ear disease and schizophrenia: case-control study. ( 18757975 )
2008
45
No negative outcomes of childhood middle ear disease in adulthood. ( 17334307 )
2007
46
Assessment of middle ear disease in the dog: a comparison of diagnostic imaging modalities. ( 17381763 )
2007
47
Comparative performance of radiography and computed tomography in the diagnosis of middle ear disease in 31 dogs. ( 16429984 )
2006
48
Does Helicobacter pylori colonize the nasopharynx of children and contribute to their middle ear disease? ( 16428192 )
2006
49
Consultations for middle ear disease, antibiotic prescribing and risk factors for reattendance: a case-linked cohort study. ( 16536956 )
2006
50
Pacific Islands families study: the prevalence of chronic middle ear disease in 2-year-old Pacific children living in New Zealand. ( 16828885 )
2006

Variations for Middle Ear Disease

Expression for Middle Ear Disease

Search GEO for disease gene expression data for Middle Ear Disease.

Pathways for Middle Ear Disease

Pathways related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 A1BG CXCL8 FGF7 IL1B IL6 MUC5AC
2
Show member pathways
13.43 AREG CXCL8 FGF7 IL1B IL6 TLR2
3
Show member pathways
13.07 CXCL8 IL1B IL6 TLR2 TLR4 TNF
4
Show member pathways
13.04 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
5
Show member pathways
13.01 AREG FGF7 IL6 TLR2 TLR4 TNF
6
Show member pathways
12.82 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
7
Show member pathways
12.77 CXCL8 IL1B IL6 TLR4 TNF
8
Show member pathways
12.68 AREG FGF7 IL1B IL6 TLR2 TLR4
9
Show member pathways
12.63 IL1B TLR2 TLR4 TLR9 TNF
10
Show member pathways
12.61 IL1B IL6 TLR2 TLR4 TNF
11
Show member pathways
12.35 CXCL8 IL1B IL6 TLR4 TNF
12
Show member pathways
12.31 CXCL8 IL1B IL6 MUC5AC MUC5B TLR2
13
Show member pathways
12.3 AREG CXCL8 FGF7 IL1B IL6 TNF
14
Show member pathways
12.28 CXCL8 IL6 TLR2 TLR4 TLR9 TNF
15
Show member pathways
12.27 IL1B TLR2 TLR4 TNF
16 12.24 IL1B IL6 TLR2 TLR4 TLR9 TNF
17
Show member pathways
12.23 IL1B IL6 TLR9 TNF
18
Show member pathways
12.22 CXCL8 IL1B TLR2 TLR4 TLR9
19 12.22 IL6 TLR2 TLR4 TLR9 TNF
20 12.2 CXCL8 IL1B IL6 TNF
21
Show member pathways
12.11 CXCL8 IL1B IL6 MUC5AC MUC5B TLR2
22
Show member pathways
12.1 AREG CXCL8 FGF7 IL1B IL6
23
Show member pathways
12.07 IL1B TLR2 TLR4 TLR9
24
Show member pathways
12.07 IL1B IL6 TLR2 TLR4 TNF
25
Show member pathways
12.07 IL1B IL6 TLR2 TLR4 TLR9 TNF
26 12.04 CXCL8 IL1B IL6 TLR4 TNF
27 12.02 CXCL8 IL1B IL6 TNF
28
Show member pathways
12.02 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
29 11.95 CXCL8 IL1B IL6 TNF
30 11.93 CXCL8 IL1B TLR4 TNF
31 11.88 IL1B IL6 TNF
32 11.87 CXCL8 IL1B IL6 TLR4
33
Show member pathways
11.86 CXCL8 IL6 TLR4
34 11.86 CXCL8 IL1B IL6 TLR2 TLR4 TNF
35 11.82 TLR2 TLR4 TLR9
36 11.8 CXCL8 IL1B IL6 TLR2 TLR4 TNF
37 11.79 IL1B IL6 TLR9 TNF
38 11.77 CXCL8 IL1B IL6 TLR4 TNF
39 11.74 IL1B IL6 TNF
40
Show member pathways
11.71 CXCL8 IL1B IL6 TNF
41 11.59 CXCL8 IL1B IL6 TNF
42 11.57 FGF7 IL6 TNF
43 11.57 IL1B TLR2 TLR4 TNF
44 11.51 IL1B IL6 TNF
45 11.4 IL1B IL6 TLR9 TNF
46 11.39 IL1B IL6 TLR4 TNF
47 11.37 CXCL8 IL1B IL6 TLR2 TLR4 TNF
48 11.34 IL1B IL6 TNF
49 11.34 AREG IL1B IL6 TNF
50 11.3 IL1B IL6 TNF

GO Terms for Middle Ear Disease

Cellular components related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 A1BG A2ML1 AREG CXCL8 IL1B IL6
2 extracellular region GO:0005576 9.4 A1BG A2ML1 CXCL8 FGF7 IL1B IL6

Biological processes related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.99 IL1B TLR4 TLR9 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.93 CXCL8 IL1B IL6 TLR4 TNF
3 inflammatory response GO:0006954 9.91 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
4 defense response to Gram-positive bacterium GO:0050830 9.89 IL6 TLR2 TNF
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 AREG FGF7 IL6
6 defense response to Gram-negative bacterium GO:0050829 9.88 IL6 TLR4 TLR9
7 positive regulation of JNK cascade GO:0046330 9.88 IL1B TLR4 TLR9 TNF
8 positive regulation of inflammatory response GO:0050729 9.88 TLR2 TLR4 TLR9 TNF
9 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 TLR4 TLR9 TNF
10 positive regulation of tumor necrosis factor production GO:0032760 9.86 TLR2 TLR4 TLR9
11 response to glucocorticoid GO:0051384 9.86 AREG IL1B IL6 TNF
12 positive regulation of interferon-gamma production GO:0032729 9.85 IL1B TLR4 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IL1B TLR4 TNF
14 positive regulation of JUN kinase activity GO:0043507 9.83 IL1B TLR9 TNF
15 toll-like receptor signaling pathway GO:0002224 9.83 TLR2 TLR4 TLR9
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.82 TLR2 TLR4 TLR9
17 negative regulation of interleukin-6 production GO:0032715 9.81 TLR4 TLR9 TNF
18 positive regulation of interferon-beta production GO:0032728 9.8 TLR2 TLR4 TLR9
19 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B IL6 TLR2 TLR4 TLR9 TNF
20 negative regulation of neurogenesis GO:0050768 9.79 IL1B IL6 TNF
21 positive regulation of interleukin-12 production GO:0032735 9.79 TLR2 TLR4 TLR9
22 positive regulation of interleukin-10 production GO:0032733 9.77 TLR2 TLR4 TLR9
23 positive regulation of glial cell proliferation GO:0060252 9.74 IL1B IL6 TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.72 TLR2 TLR4 TLR9
26 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
27 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
28 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
29 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
30 positive regulation of interferon-beta biosynthetic process GO:0045359 9.7 TLR4 TLR9
31 regulation of cytokine secretion GO:0050707 9.7 TLR2 TLR4 TLR9
32 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
33 I-kappaB phosphorylation GO:0007252 9.69 TLR2 TLR4 TLR9
34 positive regulation of fever generation GO:0031622 9.68 IL1B TNF
35 positive regulation of interleukin-18 production GO:0032741 9.68 TLR2 TLR9
36 tumor necrosis factor production GO:0032640 9.68 TLR2 TLR9
37 chronic inflammatory response to antigenic stimulus GO:0002439 9.67 IL1B TNF
38 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 TLR2 TLR9
39 positive regulation of toll-like receptor signaling pathway GO:0034123 9.66 TLR2 TLR9
40 sequestering of triglyceride GO:0030730 9.66 IL1B TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.65 IL1B TNF
42 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL1B TLR2 TLR4 TLR9 TNF
43 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.63 TLR4 TLR9 TNF
44 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.62 TLR2 TLR4
45 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B IL6 TNF
46 positive regulation of interleukin-8 production GO:0032757 9.55 IL1B TLR2 TLR4 TLR9 TNF
47 positive regulation of interleukin-6 production GO:0032755 9.43 IL1B IL6 TLR2 TLR4 TLR9 TNF
48 positive regulation of chemokine production GO:0032722 9.02 IL6 TLR2 TLR4 TLR9 TNF
49 positive regulation of cell proliferation GO:0008284 10.11 AREG FGF7 IL1B IL6 PRTN3
50 regulation of signaling receptor activity GO:0010469 10.08 AREG CXCL8 FGF7 IL1B IL6 TNF

Molecular functions related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.26 IL1B TLR9
2 signaling pattern recognition receptor activity GO:0008329 9.16 TLR2 TLR9
3 cytokine activity GO:0005125 9.02 AREG CXCL8 IL1B IL6 TNF
4 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4

Sources for Middle Ear Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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