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MCID: MDD010
MIFTS: 46

Middle Ear Disease

Categories: Ear diseases, Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Middle Ear Disease

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MalaCards integrated aliases for Middle Ear Disease:

Name: Middle Ear Disease 12 15
Disorder of Middle Ear 71
Middle Ear Anomaly 58

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:5100
NCIt 49 C27065
SNOMED-CT 67 68996008
ICD10 via Orphanet 33 Q16.3 Q16.4
UMLS via Orphanet 72 C0266599
Orphanet 58 ORPHA164004
UMLS 71 C0271428
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Summaries for Middle Ear Disease

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MalaCards based summary : Middle Ear Disease, also known as disorder of middle ear, is related to mastoiditis and auditory system disease. An important gene associated with Middle Ear Disease is DHRS2 (Dehydrogenase/Reductase 2), and among its related pathways/superpathways are Innate Immune System and NF-KappaB Family Pathway. The drugs Edetic Acid and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and eye, and related phenotypes are cellular and hematopoietic system

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Related Diseases for Middle Ear Disease

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Diseases related to Middle Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 611)
# Related Disease Score Top Affiliating Genes
1 mastoiditis 32.7 SLC29A3 PRTN3 MUC5B DHRS2 CRP CD4
2 auditory system disease 31.9 SLC29A3 DHRS2 CD40LG
3 chronic purulent otitis media 31.0 SLC29A3 PDZD11 MCAT FBXO11 DHRS2
4 otitis media 31.0 TNF TLR4 TLR2 SFTPA1 MUC5B MUC5AC
5 haemophilus influenzae 30.9 TNF TLR2
6 ankylosis 30.7 TNF CRP CCR6
7 facial paralysis 30.7 PRTN3 CRP CD40LG CD4
8 pleural empyema 30.6 DHRS2 CRP CD40LG CD4
9 nasopharyngitis 30.6 TNF CRP CD4
10 vasculitis 30.4 TNF SERPINA3 PRTN3 IL6 CRP CD40LG
11 suppurative otitis media 30.4 TLR4 TLR2 SLC29A3 PDZD11 MCAT FBXO11
12 bone resorption disease 30.4 TNF IL6 CRP CCR6
13 tonsillitis 30.4 TNF TLR4 TLR2 IL6
14 cystic fibrosis 30.2 TNF TLR4 PRTN3 MUC5B MUC5AC IL6
15 upper respiratory tract disease 30.1 TNF TLR4 TLR2 SERPINA3 IL6 CRP
16 common cold 30.0 TNF TLR4 TLR2 MUC5AC IL6 CD4
17 renal, genital, and middle ear anomalies 12.6
18 adhesive otitis media 12.1
19 mayer-rokitansky-kuster-hauser syndrome 11.2
20 riedel's fibrosing thyroiditis 10.7 CD40LG CD4
21 cork-handlers' disease 10.7 CD40LG CD4
22 syphilitic meningitis 10.7 CD40LG CD4
23 non-suppurative otitis media 10.7 SLC29A3 DHRS2
24 epiglottitis 10.7 DHRS2 CRP CD40LG
25 bicipital tenosynovitis 10.7 PRTN3 CRP
26 splenic infarction 10.7 SERPINA3 CRP CD40LG
27 drug reaction with eosinophilia and systemic symptoms 10.7 TNF CRP
28 inflammatory bowel disease 23 10.7 PRTN3 CRP
29 chancroid 10.7 CD40LG CD4 CCR6
30 neuroretinitis 10.7 CRP CD40LG CD4
31 optic papillitis 10.7 CRP CD40LG CD4
32 orbital plasma cell granuloma 10.7 PRTN3 CRP CD40LG
33 chronic orbital inflammation 10.7 PRTN3 CRP CD40LG
34 tertiary syphilis 10.7 CRP CD40LG CD4
35 intrahepatic biliary papillomatosis 10.7 MUC5B MUC5AC
36 granulomatous hepatitis 10.7 CRP CD40LG CD4
37 external pathological resorption 10.7 TNF IL6
38 cerebritis 10.7 CRP CD40LG CD4
39 cat-scratch disease 10.7 CRP CD40LG CD4
40 parotid disease 10.7 CRP CD40LG CD4
41 gastric squamous cell carcinoma 10.7 SERPINA3 CCR6
42 bartonellosis 10.7 CRP CD40LG CD4
43 mikulicz disease 10.7 CRP CD4 CCR6
44 subacute bacterial endocarditis 10.6 PRTN3 CRP CD40LG
45 bile duct mucinous adenocarcinoma 10.6 MUC5B MUC5AC
46 maxillary sinusitis 10.6 PRTN3 CRP CD40LG
47 parotitis 10.6 CRP CD40LG CD4
48 thrombocytopenia due to platelet alloimmunization 10.6 CD40LG CD4 CCR6
49 primary thrombocytopenia 10.6 CD40LG CD4 CCR6
50 duodenitis 10.6 CRP CD40LG CD4

Graphical network of the top 20 diseases related to Middle Ear Disease:



Diseases related to Middle Ear Disease
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Symptoms & Phenotypes for Middle Ear Disease

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MGI Mouse Phenotypes related to Middle Ear Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.15 CD4 CD40LG DNAH5 DNAI1 IL6 MCAT
2 hematopoietic system MP:0005397 10.13 CCR6 CD4 CD40LG DNAH5 DNAI1 FBXO11
3 cardiovascular system MP:0005385 10.1 CCR6 CD40LG CRP DNAH5 DNAI1 IL6
4 digestive/alimentary MP:0005381 9.97 CD4 DNAH5 FBXO11 IL6 MCAT MUC5AC
5 homeostasis/metabolism MP:0005376 9.97 CCR6 CD4 CD40LG CRP FBXO11 IL6
6 immune system MP:0005387 9.89 CCR6 CD4 CD40LG CRP DNAH5 DNAI1
7 respiratory system MP:0005388 9.23 DNAH5 DNAI1 IL6 MUC5B SFTPA1 TLR2
Sources

Drugs & Therapeutics for Middle Ear Disease

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Drugs for Middle Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Edetic Acid Approved, Vet_approved Phase 3 60-00-4, 62-33-9 6049
2
Iron Approved, Experimental Phase 3 7439-89-6, 15438-31-0 23925 27284
3
Pentetic acid Approved Phase 3 67-43-6
4
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
5 Hormone Antagonists Phase 3
6 Hormones Phase 3
7 Vaccines Phase 3
8 Chelating Agents Phase 3
9 Anticoagulants Phase 3
10 Iron Chelating Agents Phase 3
11 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
12 Protective Agents Phase 3
13 Antidotes Phase 3
14 Calcium, Dietary Phase 3
15 Immunologic Factors Phase 3
16
Pseudoephedrine Approved 90-82-4 7028
17
Ephedrine Approved 299-42-3 9294
18
Histamine Approved, Investigational 51-45-6 774
19
tannic acid Approved 1401-55-4
20
Lidocaine Approved, Vet_approved 137-58-6 3676
21
Oxymetazoline Approved, Investigational 1491-59-4 4636
22
Phenylephrine Approved 59-42-7 6041
23
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
24
Cocaine Approved, Illicit 50-36-2 5760 446220
25 Neurotransmitter Agents
26 Sympathomimetics
27 Adrenergic Agonists
28 Anti-Asthmatic Agents
29 Central Nervous System Stimulants
30 Respiratory System Agents
31 Vasoconstrictor Agents
32 Nasal Decongestants
33 Pharmaceutical Solutions
34
Histamine Phosphate 51-74-1 65513
35 Autonomic Agents
36 Mydriatics
37 Bronchodilator Agents
38 Adrenergic Agents
39 Trichostatin A

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease Unknown status NCT00310349 Phase 3
2 The Effect of Recombinant Human Growth Hormone Treatment on the Growth of Infants and Toddlers With Turner Syndrome Completed NCT00406926 Phase 3 Somatropin
3 PneuMum: A Randomised Controlled Trial of Pneumococcal Polysaccharide Vaccination for Aboriginal and Torres Strait Islander Mothers to Protect Their Babies From Ear Disease Completed NCT00714064 Phase 3
4 Adenoidectomy for Otitis Media in 2-3 Year Old Children Terminated NCT00016497 Phase 3
5 Hyperbaric Therapy and Healing From Deep Chemical Peel Unknown status NCT00425789 Phase 1
6 Middle Ear Pressure Regulation in Health and Disease: Gas Supply, Demand and Middle-Ear Gas Balance -- Specific Aim 1 Completed NCT01925482 Phase 1 6%CO2, 25%O2, balance N2;6% CO2, 0%O2, balance N2;20%CO2, 6%O2, balance N2;0%CO2, 6%O2, balance N2;6% CO2, 6%O2, balance N2;6%CO2, 6%O2, 0%N2, balance argon
7 Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease Unknown status NCT00222417
8 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
9 Messung Der Beweglichkeit Der Gehörknöchelchenkette während Einer Ohroperation. ("Objective Measurements of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively") Completed NCT02554422
10 Eustachian Tube Growth and Development: Anatomy/Function Completed NCT00422929
11 Early Otitis and Literacy and Attention at 9 to 11 Years Completed NCT00365092
12 Genetic Epidemiology of Otitis Media Completed NCT00422136
13 Middle Ear Pressure Disregulation in Cleft Palate Patients: Form-Function Correlates Completed NCT00423072
14 Functional Manifestations of Pressure Changes in the Middle Ear System: An fMRI Study Completed NCT01932736
15 Phase 1 Study of Protective Effect of Hyperbaric Oxygen Preconditioning on Brain and Myocardium Injury During CABG Surgery Completed NCT00817791
16 Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion Completed NCT00393900
17 Single Center Evaluation of a Sound Processor for a Transcutaneous System Completed NCT03374787
18 Reducing Environmental Tobacco Smoke in NICU Infants' Homes Completed NCT00670280
19 Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2 Completed NCT00694421
20 Novel Imaging of the Eustachian Tube; Patient Study Completed NCT02282540
21 Middle Ear Pressure Regulation in Health and Disease -- Gas Supply, Demand and Middle Ear Gas Balance -- Specific Aim 2 Completed NCT01925729 pseudoephedrine;Oxymetazoline
22 Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction Completed NCT02114762
23 Smoke-free Legislation in England and Hospital Admissions for Respiratory Tract Infections Among Children Completed NCT01920165
24 Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts Recruiting NCT03297736
25 Evaluation of the Benefits of Bilateral Fitting in Bone-anchored Hearing System Users Recruiting NCT04006132
26 Device Assisted Exercises for Improving Soft Palate and Eustachian Tube Function in Children Between Ages 6-17 With or Without Cleft Palate and With Ventilation Tubes Recruiting NCT03868891
27 The Sinonasal Cavity as a Reservoir for Upper Airway Bacterial Development Recruiting NCT03016689
28 Furlow Palatoplasty With Tensor Tenopexy for Otitis Media Active, not recruiting NCT01535131
29 Gas Supply, Demand and Middle Ear Gas Balance -- Project 1, Specific Aim 4, Protocol 3 Active, not recruiting NCT01974726
30 Eustachian Tube Function as a Predictor of Myringoplasty/Tympanoplasty Outcome Terminated NCT01766856

Search NIH Clinical Center for Middle Ear Disease

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Genetic Tests for Middle Ear Disease

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Anatomical Context for Middle Ear Disease

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MalaCards organs/tissues related to Middle Ear Disease:

40
Bone, Lung, Eye, Skin, Testes, T Cells, Brain
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Publications for Middle Ear Disease

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Articles related to Middle Ear Disease:

(show top 50) (show all 991)
# Title Authors PMID Year
1
Isolated Congenital Middle Ear Malformations: Comparison of Preoperative High-Resolution CT and Surgical Findings. 61
31631685 2020
2
Hearing in Schoolchildren After Neonatal Exposure to a High-Dose Gentamicin Regimen. 61
31915192 2020
3
Open Mastoid Cavity Obliteration With a High-Porosity Hydroxyapatite Ceramic Leads to High Rate of Revision Surgery and Insufficient Cavity Obliteration. 61
31584500 2020
4
Establishing the minimal clinically important difference (MCID) of the Zurich Chronic Middle Ear Inventory (ZCMEI-21) in patients treated for chronic middle ear disease. 61
31989271 2020
5
Subannular ventilation tubes in the pediatric population: Clinical outcomes of over 1000 insertions. 61
31918244 2020
6
Endoscopic ear surgery in children with down syndrome. 61
31972386 2020
7
Reconstructing the Neanderthal Eustachian Tube: New Insights on Disease Susceptibility, Fitness Cost, and Extinction. 61
31472033 2019
8
Mastoid Obliteration with Synthetic Materials: A Review of the Literature. 61
31846919 2019
9
Temporal changes in childhood health during the medieval Little Ice Age in Denmark. 61
31675550 2019
10
The Effect of Nitrous Oxide on the Outcomes of Underlay Tympanoplasty: A Prospective Study. 61
31035784 2019
11
Transcanal Endoscopic Ear Surgery for Congenital Middle Ear Anomalies. 61
31634283 2019
12
Cochlear implants in eight children with Down Syndrome - Auditory performance and challenges in assessment. 61
31442869 2019
13
Comparison of Endoscope-Assisted Coblation Adenoidectomy to Conventional Curettage Adenoidectomy in Terms of Postoperative Eustachian Tube Function. 61
31764564 2019
14
External Auditory Canal Paraganglioma with Chronic Otitis Media of Ear: A Rare Coexistence. 61
31750154 2019
15
Prevalence of Otitis Media with Effusion in Children with Hearing Loss. 61
31750164 2019
16
Prevalence of middle ear disease in Chilean natives and the impact of development over 14 years. 61
31753782 2019
17
Hearing and justice: The link between hearing impairment in early childhood and youth offending in Aboriginal children living in remote communities of the Northern Territory, Australia. 61
31667630 2019
18
Principles of Pediatric Endoscopic Ear Surgery. 61
31353138 2019
19
Comparison of complications and outcome following unilateral, staged bilateral, and single-stage bilateral ventral bulla osteotomy in cats. 61
31517583 2019
20
The Association Between Hearing Impairment and Problem Behaviors in 11-Year-Old Pacific Children Living in New Zealand. 61
31567496 2019
21
Tri-layer Tympanoplasty as a New Technique in High-risk Tympanic Membrane Perforations. 61
31598492 2019
22
Does access to saltwater swimming pools reduce ear pathology and hearing loss in school children of remote arid zone aboriginal communities? A prospective 3-year cohort study. 61
31095860 2019
23
Surgical, speech, and hearing outcomes at five years of age in internationally adopted children and Swedish-born children with cleft lip and/or palate. 61
31393744 2019
24
Model-based hearing diagnostics based on wideband tympanometry measurements utilizing fuzzy arithmetic. 61
30878271 2019
25
Precision Motion Control using Nonlinear Contact Force Model in a Surgical Device. 61
31947071 2019
26
Tele-Audiological Surveillance of Middle Ear Status among Individuals with Cleft Lip and/or Palate in Rural South India. 61
31304913 2019
27
Computed tomographic grading of middle ear disease in domestic rabbits (Oryctolagus cuniculi). 61
31147450 2019
28
Contribution of the Use of a Pen-Type Endoscope to Evaluate and Treat Ears Simultaneously During Cleft Palate Surgery in Late Presented Cases. 61
30865113 2019
29
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease. 61
31086039 2019
30
Annual hearing screening in girls with Turner Syndrome: Results from the first three years in Glasgow. 61
30798112 2019
31
Influence of ossicular chain malformation on the performance of round-window stimulation: A finite element approach. 61
30919729 2019
32
Comparison of total and partial ossicular replacement prostheses in patients with an intact stapes suprastructure. 61
31077404 2019
33
Association of Tympanostomy Tubes With Future Risk of Advanced Ear Surgery-A Population Study. 61
30870361 2019
34
Otitis media and mastoiditis in temporal bones of prehistoric Chilean populations. A paleopathological and paleoepidemiological study. 61
30794067 2019
35
[Acoustic absorbance characteristics of wideband tympanometry in patients with Meniere's disease]. 61
30813690 2019
36
Hearing and ear status of Pacific children aged 11 years living in New Zealand: the Pacific Islands families hearing study. 61
30261774 2019
37
Clinical analysis and nonsurgical management of 11 dogs with aural cholesteatoma. 61
30637895 2019
38
Association of Tympanostomy Tubes With Future Risk of Advanced Ear Surgery-A Population Study. 61
30789567 2019
39
Numerical Study and Optimization of a Novel Piezoelectric Transducer for a Round-Window Stimulating Type Middle-Ear Implant. 61
30634413 2019
40
The Bos taurus maternal microbiome: Role in determining the progeny early-life upper respiratory tract microbiome and health. 61
30840624 2019
41
Cholesteatoma in a cat. 61
31205737 2019
42
Global burden of hearing impairment and ear disease. 61
30047343 2019
43
Aminoglycoside Vestibulotoxicity. 61
30947191 2019
44
Audiological function in a group of adults following myringoplasty: an exploratory study in South Africa. 61
31803343 2019
45
Isolation and Culture of Primary Mouse Middle Ear Epithelial Cells. 61
30788824 2019
46
Correlation between Type of Clefting and the Incidence of Otitis Media among Children with Lip and/or Palate Clefts. 61
31722340 2019
47
The prevalence of otitis media in 2-3 year old Cameroonian children estimated by tympanometry. 61
30368383 2018
48
Middle-ear disease in children with cleft palate. 61
29764722 2018
49
Classification of facial nerve aberration in congenital malformation of middle ear: Implications for surgery of hearing restoration. 61
30671087 2018
50
Cleft Lip and Palate. 61
30396411 2018
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Variations for Middle Ear Disease

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Expression for Middle Ear Disease

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Search GEO for disease gene expression data for Middle Ear Disease.
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Pathways for Middle Ear Disease

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Pathways related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.92 TNF TLR4 TLR2 SERPINA3 PRTN3 PDZD11
2
NF-KappaB Family Pathway 63
Show member pathways
 12.64 TNF TLR4 TLR2 IL6 CD40LG
3
Th17 cell differentiation 36
Show member pathways
 12.51 TNF TLR4 TLR2 IL6 CD4
4
T cell receptor signaling pathway 36
Show member pathways
 12.39 TNF TLR4 TLR2 IL6 CD40LG CD4
5
Folate Metabolism 1
Show member pathways
 12.26 TNF SERPINA3 IL6 CRP
6
IL-17 Family Signaling Pathways 64
Show member pathways
 12.23 TNF TLR2 MUC5B MUC5AC IL6
7
Defensins 65
Show member pathways
 12.21 TLR2 PRTN3 PDZD11 CD4 CCR6
8
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.19 TNF TLR4 TLR2 IL6
9
Toxoplasmosis 36
Show member pathways
 12.18 TNF TLR4 TLR2 CD40LG
10
Tuberculosis 36
12.15 TNF TLR4 TLR2 IL6
11
Colorectal Cancer Metastasis 63
12.11 TNF TLR4 TLR2 IL6
12
IL-1 Family Signaling Pathways 64
Show member pathways
 12.05 TNF TLR2 MUC5B MUC5AC IL6
13
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.96 TNF TLR4 TLR2 IL6
14
Bacterial infections in CF airways 22
Show member pathways
 11.87 TNF TLR4 TLR2 SFTPA1 IL6
15
Amoebiasis 36
11.85 TNF TLR4 TLR2 IL6
16
Rheumatoid arthritis 36
11.79 TNF TLR4 TLR2 IL6
17
Innate Lymphoid Cell Differentiation Pathways 64
11.72 TNF CD4 CCR6
18
Dendritic Cells Developmental Lineage Pathway 64
11.68 TNF IL6 CD4
19
NF-kB (NFkB) Pathway 66
11.67 TNF TLR4 CD4
20
Pertussis 36
11.61 TNF TLR4 SFTPA1 IL6
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 TNF IL6 CD40LG
22
Th1 Differentiation Pathway 64
Show member pathways
 11.47 TNF TLR4 TLR2 IL6 CD4
23
MSP-RON Signaling 63
11.44 TNF TLR4 TLR2
24
Lung fibrosis 1
11.42 TNF SFTPA1 MUC5B IL6
25
IL-10 Pathway 63
11.29 TNF TLR4 IL6
26
Legionellosis 36
11.21 TNF TLR4 TLR2 IL6
27
Cytokines and Inflammatory Response 1
11.19 TNF IL6 CD4
28
Overview of nanoparticle effects 1
10.91 TNF IL6 CRP
29
Malaria 36
10.72 TNF TLR4 TLR2 IL6 CD40LG
Sources

GO Terms for Middle Ear Disease

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Cellular components related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.67 TNF TLR2 PRTN3 CD4
2 external side of plasma membrane GO:0009897 9.65 TNF TLR4 CD40LG CD4 CCR6
3 cell surface GO:0009986 9.63 TNF TLR4 TLR2 CD40LG CD4 CCR6
4 extracellular space GO:0005615 9.61 TNF SFTPA1 SERPINA3 PRTN3 MUC5B MUC5AC
5 extracellular region GO:0005576 9.4 TNF SFTPA1 SERPINA3 PRTN3 PDZD11 MUC5B
6 outer dynein arm GO:0036157 9.32 DNAI1 DNAH5

Biological processes related to Middle Ear Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10 TNF TLR4 TLR2 IL6 CRP
2 defense response to Gram-positive bacterium GO:0050830 9.8 TNF TLR2 IL6 CRP
3 immune response GO:0006955 9.8 TNF TLR4 TLR2 IL6 CD40LG CD4
4 positive regulation of T cell proliferation GO:0042102 9.77 IL6 CD40LG CD4
5 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.76 TNF TLR4 TLR2
6 humoral immune response GO:0006959 9.75 TNF IL6 CCR6
7 toll-like receptor signaling pathway GO:0002224 9.73 TLR4 TLR2 SFTPA1
8 acute-phase response GO:0006953 9.72 SERPINA3 IL6 CRP
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 TNF TLR4 TLR2 IL6 CD40LG
10 positive regulation of interleukin-6 secretion GO:2000778 9.71 TNF TLR4 TLR2
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.7 TNF TLR4 TLR2
12 positive regulation of interleukin-8 production GO:0032757 9.69 TNF TLR4 TLR2
13 positive regulation of interleukin-6 production GO:0032755 9.67 TNF TLR4 TLR2 IL6
14 positive regulation of interleukin-12 production GO:0032735 9.65 TLR4 TLR2 CD40LG
15 cellular response to lipoteichoic acid GO:0071223 9.61 TLR4 TLR2
16 opsonization GO:0008228 9.61 SFTPA1 CRP
17 positive regulation of interleukin-10 production GO:0032733 9.58 TLR4 TLR2 CD40LG
18 regulation of immunoglobulin secretion GO:0051023 9.57 TNF CD40LG
19 inflammatory response GO:0006954 9.5 TNF TLR4 TLR2 SERPINA3 IL6 CRP
20 positive regulation of matrix metallopeptidase secretion GO:1904466 9.46 TLR4 TLR2
21 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.43 TLR4 TLR2
22 negative regulation of lipid storage GO:0010888 9.33 TNF IL6 CRP
23 positive regulation of chemokine production GO:0032722 8.92 TNF TLR4 TLR2 IL6

Molecular functions related to Middle Ear Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TNF TLR4 TLR2 SLC29A3 SFTPA1 SERPINA3
2 signaling receptor activity GO:0038023 9.46 TLR4 TLR2 CD4 CCR6
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR4 TLR2
Sources

Sources for Middle Ear Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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