MCID: MDD007
MIFTS: 23

Middle Ear Squamous Cell Carcinoma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Middle Ear Squamous Cell Carcinoma

MalaCards integrated aliases for Middle Ear Squamous Cell Carcinoma:

Name: Middle Ear Squamous Cell Carcinoma 12 15 73
Epidermoid Carcinoma of the Middle Ear 12
Squamous Cell Carcinoma of Middle Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5526
NCIt 50 C6086
UMLS 73 C1334762

Summaries for Middle Ear Squamous Cell Carcinoma

Disease Ontology : 12 A middle ear carcinoma that has material basis in squamous cells.

MalaCards based summary : Middle Ear Squamous Cell Carcinoma, also known as epidermoid carcinoma of the middle ear, is related to middle ear carcinoma and squamous cell carcinoma. An important gene associated with Middle Ear Squamous Cell Carcinoma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are MicroRNAs in cancer and Matrix Metalloproteinases. Related phenotypes are Increased gamma-H2AX phosphorylation and integument

Related Diseases for Middle Ear Squamous Cell Carcinoma

Diseases related to Middle Ear Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 middle ear carcinoma 29.0 MMP9 RECK
2 squamous cell carcinoma 10.4
3 papilloma 9.9
4 psammomatous meningioma 9.8 CD34 MMP9
5 internal hemorrhoid 9.7 CD34 MMP9
6 cell type cancer 9.6 CD34 MMP9
7 gastrointestinal system cancer 9.5 CD34 MMP9
8 bone cancer 9.3 MMP9 RECK
9 cholangiocarcinoma 8.9 MMP9 RECK

Graphical network of the top 20 diseases related to Middle Ear Squamous Cell Carcinoma:



Diseases related to Middle Ear Squamous Cell Carcinoma

Symptoms & Phenotypes for Middle Ear Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 8.8 MMP9 RECK CD34

MGI Mouse Phenotypes related to Middle Ear Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.8 MMP9 RECK CD34

Drugs & Therapeutics for Middle Ear Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Middle Ear Squamous Cell Carcinoma

Genetic Tests for Middle Ear Squamous Cell Carcinoma

Anatomical Context for Middle Ear Squamous Cell Carcinoma

Publications for Middle Ear Squamous Cell Carcinoma

Articles related to Middle Ear Squamous Cell Carcinoma:

# Title Authors Year
1
Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma. ( 29456946 )
2018
2
Giant middle ear squamous cell carcinoma mimicking as cholesteatoma. ( 22193618 )
2012
3
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. ( 22178867 )
2012
4
[Study on the expression and clinical significance of MMP9 and MVD in the external auditory canal and middle ear squamous cell carcinoma]. ( 21710717 )
2011
5
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. ( 19381105 )
2009
6
A case of bilateral middle-ear squamous cell carcinoma. ( 11667995 )
2001
7
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. ( 10077254 )
1999
8
Bilateral middle-ear squamous cell carcinoma. A case report. ( 3388158 )
1988

Variations for Middle Ear Squamous Cell Carcinoma

Cosmic variations for Middle Ear Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10690 TP53 upper aerodigestive tract,middle ear,carcinoma,squamous cell carcinoma c.473G>A p.R158H 17:7675139-7675139 13

Expression for Middle Ear Squamous Cell Carcinoma

Search GEO for disease gene expression data for Middle Ear Squamous Cell Carcinoma.

Pathways for Middle Ear Squamous Cell Carcinoma

Pathways related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 MMP9 RECK
2
Show member pathways
10.95 MMP9 RECK
3 10.57 MMP9 RECK

GO Terms for Middle Ear Squamous Cell Carcinoma

Cellular components related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.8 CD34 MMP9 RECK

Biological processes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.16 CD34 MMP9
2 extracellular matrix organization GO:0030198 8.96 MMP9 RECK
3 embryo implantation GO:0007566 8.62 MMP9 RECK

Sources for Middle Ear Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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