MCID: MDD007
MIFTS: 23

Middle Ear Squamous Cell Carcinoma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Middle Ear Squamous Cell Carcinoma

MalaCards integrated aliases for Middle Ear Squamous Cell Carcinoma:

Name: Middle Ear Squamous Cell Carcinoma 12 15 17 70
Epidermoid Carcinoma of the Middle Ear 12
Squamous Cell Carcinoma of Middle Ear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5526
NCIt 50 C6086
UMLS 70 C1334762

Summaries for Middle Ear Squamous Cell Carcinoma

Disease Ontology : 12 A middle ear carcinoma that has material basis in squamous cells.

MalaCards based summary : Middle Ear Squamous Cell Carcinoma, also known as epidermoid carcinoma of the middle ear, is related to middle ear carcinoma and bone squamous cell carcinoma. An important gene associated with Middle Ear Squamous Cell Carcinoma is RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs), and among its related pathways/superpathways are MicroRNAs in cancer and Matrix Metalloproteinases. Related phenotypes are integument and neoplasm

Related Diseases for Middle Ear Squamous Cell Carcinoma

Diseases related to Middle Ear Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 middle ear carcinoma 29.7 RECK MMP9 CDKN2A
2 bone squamous cell carcinoma 29.7 RECK MMP9 CDKN2A
3 skin carcinoma 29.5 MMP9 CDKN2A CD34
4 squamous cell carcinoma 10.5
5 squamous cell papilloma 10.3
6 papilloma 10.3
7 otitis media 10.1
8 rapidly involuting congenital hemangioma 10.1
9 cholesteatoma of middle ear 10.1
10 facial paralysis 10.1
11 lung giant cell carcinoma 10.0 MMP9 CDKN2A
12 verrucous carcinoma 10.0 MMP9 CDKN2A
13 actinic keratosis 10.0 MMP9 CDKN2A
14 oral cancer 10.0 MMP9 CDKN2A
15 tongue disease 10.0 MMP9 CDKN2A
16 ductal carcinoma in situ 10.0 MMP9 CDKN2A
17 anaplastic astrocytoma 9.9 MMP9 CDKN2A
18 gliosarcoma 9.9 MMP9 CDKN2A
19 transitional cell carcinoma 9.9 MMP9 CDKN2A
20 inflammatory liposarcoma 9.9 CDKN2A CD34
21 liposarcoma 9.9 CDKN2A CD34
22 infiltrating angiolipoma 9.9 CDKN2A CD34
23 adult malignant schwannoma 9.9 CDKN2A CD34
24 angiokeratoma circumscriptum 9.9 MMP9 CD34
25 atypical neurofibroma 9.9 CDKN2A CD34
26 neurofibroma 9.9 CDKN2A CD34
27 nasal cavity benign neoplasm 9.9 MMP9 CD34
28 tongue squamous cell carcinoma 9.9 MMP9 CDKN2A
29 ischemic fasciitis 9.9 CDKN2A CD34
30 tenosynovial giant cell tumor 9.9 CDKN2A CD34
31 gliofibroma 9.9 CDKN2A CD34
32 malignant spindle cell melanoma 9.9 CDKN2A CD34
33 retroperitoneum carcinoma 9.9 CDKN2A CD34
34 neurofibrosarcoma 9.9 CDKN2A CD34
35 vulvar disease 9.9 CDKN2A CD34
36 vulvar dystrophy 9.9 CDKN2A CD34
37 respiratory system benign neoplasm 9.9 CDKN2A CD34
38 glomus tumor 9.9 CDKN2A CD34
39 follicular dendritic cell sarcoma 9.9 CDKN2A CD34
40 reproductive organ benign neoplasm 9.9 CDKN2A CD34
41 desmoid tumor 9.8 CDKN2A CD34
42 well-differentiated liposarcoma 9.8 CDKN2A CD34
43 precursor t-cell acute lymphoblastic leukemia 9.8 CDKN2A CD34
44 dedifferentiated liposarcoma 9.8 CDKN2A CD34
45 moyamoya disease 1 9.8 MMP9 CD34
46 dermatofibrosarcoma protuberans 9.8 CDKN2A CD34
47 giant cell glioblastoma 9.8 CDKN2A CD34
48 b-lymphoblastic leukemia/lymphoma 9.8 CDKN2A CD34
49 peripheral nervous system neoplasm 9.8 CDKN2A CD34
50 cell type benign neoplasm 9.8 CDKN2A CD34

Graphical network of the top 20 diseases related to Middle Ear Squamous Cell Carcinoma:



Diseases related to Middle Ear Squamous Cell Carcinoma

Symptoms & Phenotypes for Middle Ear Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Middle Ear Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 CD34 CDKN2A MMP9 RECK
2 neoplasm MP:0002006 8.8 CD34 CDKN2A MMP9

Drugs & Therapeutics for Middle Ear Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Middle Ear Squamous Cell Carcinoma

Genetic Tests for Middle Ear Squamous Cell Carcinoma

Anatomical Context for Middle Ear Squamous Cell Carcinoma

Publications for Middle Ear Squamous Cell Carcinoma

Articles related to Middle Ear Squamous Cell Carcinoma:

(show all 14)
# Title Authors PMID Year
1
HPV Infection in Middle Ear Squamous Cell Carcinoma: Prevalence, Genotyping and Prognostic Impact. 61
33673300 2021
2
Beta human papillomaviruses in middle ear squamous cell carcinoma. 61
30665705 2019
3
Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma. 61
29456946 2018
4
Outcomes of 18 cases with squamous cell carcinoma of middle ear who underwent both surgery and post-operative radiotherapy. 61
26472473 2016
5
Giant middle ear squamous cell carcinoma mimicking as cholesteatoma. 61
22193618 2012
6
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. 61
22178867 2012
7
[Study on the expression and clinical significance of MMP9 and MVD in the external auditory canal and middle ear squamous cell carcinoma]. 61
21710717 2011
8
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. 61
19381105 2009
9
[Middle ear cancer hidden by chronic otitis media--a case report]. 61
19205537 2008
10
[A case of squamous-cell carcinoma originating in external auditory canal cholesteatoma]. 61
12928719 2003
11
A case of bilateral middle-ear squamous cell carcinoma. 61
11667995 2001
12
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. 61
10077254 1999
13
[Brain abscess as a complication of ear malignancy: a case report]. 61
8851995 1995
14
Bilateral middle-ear squamous cell carcinoma. A case report. 61
3388158 1988

Variations for Middle Ear Squamous Cell Carcinoma

Expression for Middle Ear Squamous Cell Carcinoma

Search GEO for disease gene expression data for Middle Ear Squamous Cell Carcinoma.

Pathways for Middle Ear Squamous Cell Carcinoma

Pathways related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 RECK MMP9 CDKN2A
2
Show member pathways
11.25 RECK MMP9
3 11.11 RECK MMP9
4 10.82 MMP9 CDKN2A

GO Terms for Middle Ear Squamous Cell Carcinoma

Biological processes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryo implantation GO:0007566 8.62 RECK MMP9

Sources for Middle Ear Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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