Middle Ear Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Middle Ear Squamous Cell Carcinoma

MalaCards integrated aliases for Middle Ear Squamous Cell Carcinoma:

Name: Middle Ear Squamous Cell Carcinoma ¹² ¹⁵ ⁷³

Epidermoid Carcinoma of the Middle Ear ¹²

Squamous Cell Carcinoma of Middle Ear ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Ear diseases Neuronal diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5526

NCIt ⁵⁰ C6086

UMLS ⁷³ C1334762

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Summaries for Middle Ear Squamous Cell Carcinoma

Disease Ontology : ¹² A middle ear carcinoma that has material basis in squamous cells.

MalaCards based summary : Middle Ear Squamous Cell Carcinoma, also known as epidermoid carcinoma of the middle ear, is related to middle ear carcinoma and squamous cell carcinoma. An important gene associated with Middle Ear Squamous Cell Carcinoma is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are MicroRNAs in cancer and Matrix Metalloproteinases. Affiliated tissues include skin and bone, and related phenotypes are Increased gamma-H2AX phosphorylation and integument

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Related Diseases for Middle Ear Squamous Cell Carcinoma

Diseases related to Middle Ear Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	middle ear carcinoma	30.0	MMP9 RECK
2	squamous cell carcinoma	10.5
3	papilloma	10.0
4	psammomatous meningioma	9.9	CD34 MMP9
5	internal hemorrhoid	9.9	CD34 MMP9
6	gastrointestinal system cancer	9.9	CD34 MMP9
7	bone cancer	9.8	MMP9 RECK
8	large intestine cancer	9.8	CD34 MMP9
9	cholangiocarcinoma	9.7	MMP9 RECK

Graphical network of the top 20 diseases related to Middle Ear Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Middle Ear Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased gamma-H2AX phosphorylation	GR00053-A	8.8	CD34 MMP9 RECK

MGI Mouse Phenotypes related to Middle Ear Squamous Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	8.8	CD34 MMP9 RECK

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Drugs & Therapeutics for Middle Ear Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Middle Ear Squamous Cell Carcinoma

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Genetic Tests for Middle Ear Squamous Cell Carcinoma

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Anatomical Context for Middle Ear Squamous Cell Carcinoma

MalaCards organs/tissues related to Middle Ear Squamous Cell Carcinoma:

⁴¹

Skin, Bone

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Publications for Middle Ear Squamous Cell Carcinoma

Articles related to Middle Ear Squamous Cell Carcinoma:

#	Title	Authors	Year
1	Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma. ( 29456946 )	Surono A....Samodra E.	2018
2	Giant middle ear squamous cell carcinoma mimicking as cholesteatoma. ( 22193618 )	Tomazic P.V....Walch C.	2012
3	Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. ( 22178867 )		2012
4	[Study on the expression and clinical significance of MMP9 and MVD in the external auditory canal and middle ear squamous cell carcinoma]. ( 21710717 )		2011
5	Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. ( 19381105 )	Cristalli G....Spriano G.	2009
6	A case of bilateral middle-ear squamous cell carcinoma. ( 11667995 )	Takano A....Kobayashi T.	2001
7	Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. ( 10077254 )		1999
8	Bilateral middle-ear squamous cell carcinoma. A case report. ( 3388158 )	Snyman J....Claassen A.J.	1988

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Genes for Middle Ear Squamous Cell Carcinoma

Genes related to Middle Ear Squamous Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MMP9	Matrix Metallopeptidase 9	Protein Coding	22.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	RECK	Reversion Inducing Cysteine Rich Protein With Kazal Motifs	Protein Coding	13.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CD34	CD34 Molecule	Protein Coding	7.21	GeneCards inferred via : Publications (show sections)

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Variations for Middle Ear Squamous Cell Carcinoma

Cosmic variations for Middle Ear Squamous Cell Carcinoma:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM10690	TP53	upper aerodigestive tract,middle ear,carcinoma,squamous cell carcinoma	c.473G>A	p.R158H	17:7675139-7675139	13

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Expression for Middle Ear Squamous Cell Carcinoma

Search GEO for disease gene expression data for Middle Ear Squamous Cell Carcinoma.

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Pathways for Middle Ear Squamous Cell Carcinoma

Pathways related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cancer ³⁷	11.63	MMP9 RECK
2	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	10.95	MMP9 RECK
3	Angiogenesis (CST) ⁴	10.57	MMP9 RECK

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GO Terms for Middle Ear Squamous Cell Carcinoma

Cellular components related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	8.8	CD34 MMP9 RECK

Biological processes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:0030198	9.16	MMP9 RECK
2	leukocyte migration	GO:0050900	8.96	CD34 MMP9
3	embryo implantation	GO:0007566	8.62	MMP9 RECK

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Sources for Middle Ear Squamous Cell Carcinoma

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