Middle Ear Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Middle Ear Squamous Cell Carcinoma, also known as squamous cell carcinoma of middle ear, is related to middle ear carcinoma and bone squamous cell carcinoma. An important gene associated with Middle Ear Squamous Cell Carcinoma is RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs), and among its related pathways/superpathways are Senescence and autophagy in cancer and Matrix metalloproteinases. Affiliated tissues include bone and brain.

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Related Diseases for Middle Ear Squamous Cell Carcinoma

Diseases related to Middle Ear Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Related Disease	Score	Top Affiliating Genes
1	middle ear carcinoma	30.3	RECK GP5
2	bone squamous cell carcinoma	29.7	RECK MMP9 CDKN2A
3	squamous cell carcinoma	10.5
4	bell's palsy	10.3
5	papilloma	10.3
6	otitis media	10.1
7	rapidly involuting congenital hemangioma	10.1
8	otorrhea	10.1
9	cholesteatoma of middle ear	10.1
10	facial paralysis	10.1
11	skin carcinoma	10.1
12	chromoblastomycosis	10.0	MMP9 CCL3
13	tropical spastic paraparesis	10.0	MMP9 CCL3
14	inverted follicular keratosis	10.0	GP6 GP5
15	focal epithelial hyperplasia	10.0	GP6 GP5
16	cervical adenosarcoma	9.9	GP6 GP5
17	proteasome-associated autoinflammatory syndrome 1	9.9	MMP9 CCL3
18	carotid artery disease	9.9	MMP9 GP6
19	neuritis	9.9	MMP9 CCL3
20	glanzmann thrombasthenia 1	9.9	RECK GP6
21	lyme disease	9.9	MMP9 CCL3
22	gray platelet syndrome	9.9	GP6 GP5
23	keratosis	9.9	MMP9 CDKN2A
24	relapsing-remitting multiple sclerosis	9.9	MMP9 CCL3
25	cervical clear cell adenocarcinoma	9.9	GP5 CDKN2A
26	squamous cell papilloma	9.9	GP5 CDKN2A
27	bronchial disease	9.9	MMP9 CCL3
28	penile benign neoplasm	9.9	GP5 CDKN2A
29	lip and oral cavity cancer	9.8	MMP9 CDKN2A
30	male reproductive organ benign neoplasm	9.8	GP5 CDKN2A
31	vaginal cancer	9.8	GP5 CDKN2A
32	phimosis	9.8	GP5 CDKN2A
33	verrucous carcinoma	9.8	GP5 CDKN2A
34	vulva squamous cell carcinoma	9.8	GP5 CDKN2A
35	adenocarcinoma in situ	9.8	GP5 CDKN2A
36	vulvar disease	9.8	GP5 CDKN2A
37	penile disease	9.8	GP5 CDKN2A
38	breast carcinoma in situ	9.8	MMP9 CDKN2A
39	anus disease	9.8	GP5 CDKN2A
40	ductal carcinoma in situ	9.8	MMP9 CDKN2A
41	rectal disease	9.8	GP5 CDKN2A
42	soft palate cancer	9.8	GP6 CDKN2A
43	vulva cancer	9.8	GP5 CDKN2A
44	oropharynx cancer	9.8	GP5 CDKN2A
45	bernard-soulier syndrome	9.8	RECK GP6 GP5
46	blood platelet disease	9.7	RECK GP6 GP5
47	human papillomavirus infectious disease	9.7	GP5 CDKN2A
48	vascular disease	9.7	RECK MMP9 GP6
49	stroke, ischemic	9.7	MMP9 GP6 CCL3
50	cholangiocarcinoma	9.7	RECK MMP9 CDKN2A

Graphical network of the top 20 diseases related to Middle Ear Squamous Cell Carcinoma:

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Symptoms & Phenotypes for Middle Ear Squamous Cell Carcinoma

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Drugs & Therapeutics for Middle Ear Squamous Cell Carcinoma

Search Clinical Trials, NIH Clinical Center for Middle Ear Squamous Cell Carcinoma

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Genetic Tests for Middle Ear Squamous Cell Carcinoma

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Anatomical Context for Middle Ear Squamous Cell Carcinoma

Organs/tissues related to Middle Ear Squamous Cell Carcinoma:

MalaCards : Bone, Brain

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Publications for Middle Ear Squamous Cell Carcinoma

Articles related to Middle Ear Squamous Cell Carcinoma:

(show all 18)

#	Title	Authors	PMID	Year
1	Clinical outcomes of temporal bone squamous cell carcinoma: A single-institution experience. ⁶²	Zheng Y...Zhao Y	36229984	2022
2	The revised Pittsburgh staging system for middle ear squamous cell carcinoma: A challenging clinical dilemma. ⁶²	Mao M...Zhao Y	35384118	2022
3	Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma. ⁶²	Qiu K...Zhao Y	34559476	2021
4	HPV Infection in Middle Ear Squamous Cell Carcinoma: Prevalence, Genotyping and Prognostic Impact. ⁶²	Cristalli G...Boscolo Nata F	33673300	2021
5	Beta human papillomaviruses in middle ear squamous cell carcinoma. ⁶²	Paolini F...Venuti A	30665705	2019
6	Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma. ⁶²	Surono A...Samodra E	29456946	2018
7	Outcomes of 18 cases with squamous cell carcinoma of middle ear who underwent both surgery and post-operative radiotherapy. ⁶²	Feng L...Xu P	26472473	2016
8	Giant middle ear squamous cell carcinoma mimicking as cholesteatoma. ⁶²	Tomazic PV...Walch C	22193618	2012
9	Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. ⁶²	Liu X...Cao L	22178867	2012
10	[Study on the expression and clinical significance of MMP9 and MVD in the external auditory canal and middle ear squamous cell carcinoma]. ⁶²	Liu X...Zhou J	21710717	2011
11	Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. ⁶²	Cristalli G...Spriano G	19381105	2009
12	[Middle ear cancer hidden by chronic otitis media--a case report]. ⁶²	Wierzbicka M...Kopec T	19205537	2008
13	[A case of squamous-cell carcinoma originating in external auditory canal cholesteatoma]. ⁶²	Aoki H...Matsumoto K	12928719	2003
14	A case of bilateral middle-ear squamous cell carcinoma. ⁶²	Takano A...Kobayashi T	11667995	2001
15	Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. ⁶²	Suzuki K...Baba S	10077254	1999
16	[Brain abscess as a complication of ear malignancy: a case report]. ⁶²	Liu CM...Su CY	8851995	1995
17	Bilateral middle-ear squamous cell carcinoma. A case report. ⁶²	Snyman J...Claassen AJ	3388158	1988
18	Radiotherapy in carcinoma of the middle ear and auditory canal. ⁶²	Arthur K	182892	1976

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Genes for Middle Ear Squamous Cell Carcinoma

Genes related to Middle Ear Squamous Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RECK	Reversion Inducing Cysteine Rich Protein With Kazal Motifs	Protein Coding	5.61	DISEASES inferred ¹⁴
2	MMP9	Matrix Metallopeptidase 9	Protein Coding	4.68	DISEASES inferred ¹⁴
3	GP5	Glycoprotein V Platelet	Protein Coding	4.3	DISEASES inferred ¹⁴
4	GP6	Glycoprotein VI Platelet	Protein Coding	3.98	DISEASES inferred ¹⁴
5	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.86	DISEASES inferred ¹⁴
6	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	2.94	DISEASES inferred ¹⁴

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Variations for Middle Ear Squamous Cell Carcinoma

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Expression for Middle Ear Squamous Cell Carcinoma

Search GEO for disease gene expression data for Middle Ear Squamous Cell Carcinoma.

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Pathways for Middle Ear Squamous Cell Carcinoma

Pathways related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Senescence and autophagy in cancer ⁷⁴	11.52	CDKN2A CCL3
2	Matrix metalloproteinases ⁷⁴ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.48	RECK MMP9
3	Angiogenesis (CST) ³	11.41	RECK MMP9
4	Regulation of nuclear beta catenin signaling and target gene transcription ⁶¹	11.29	MMP9 CDKN2A
5	AP-1 transcription factor network ⁶¹	11.24	MMP9 CDKN2A
6	Lung fibrosis ⁷⁴	11.17	MMP9 CCL3
7	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	11.03	GP6 GP5
8	Bladder cancer ⁷⁴	10.86	MMP9 CDKN2A
9	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	10.7	MMP9 CDKN2A
10	Prostaglandin signaling ⁷⁴	10.4	MMP9 CCL3
11	Platelet Adhesion to exposed collagen ⁶⁶ Show member pathways GP1b-IX-V activation signalling ⁶⁶	10.05	GP6 GP5

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GO Terms for Middle Ear Squamous Cell Carcinoma

Biological processes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	embryo implantation	GO:0007566	9.26	RECK MMP9
2	hemostasis	GO:0007599	8.62	GP6 GP5

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Sources for Middle Ear Squamous Cell Carcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MDD007 MIFTS: 25	Middle Ear Squamous Cell Carcinoma Categories: Cancer diseases, Ear diseases, Neuronal diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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