MCID: MDD007
MIFTS: 25

Middle Ear Squamous Cell Carcinoma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Skin diseases
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Aliases & Classifications for Middle Ear Squamous Cell Carcinoma

Summaries for Middle Ear Squamous Cell Carcinoma

Disease Ontology: 11 A middle ear carcinoma that has material basis in squamous cells.

MalaCards based summary: Middle Ear Squamous Cell Carcinoma, also known as squamous cell carcinoma of middle ear, is related to middle ear carcinoma and bone squamous cell carcinoma. An important gene associated with Middle Ear Squamous Cell Carcinoma is RECK (Reversion Inducing Cysteine Rich Protein With Kazal Motifs), and among its related pathways/superpathways are Senescence and autophagy in cancer and Matrix metalloproteinases. Affiliated tissues include bone and brain.

Related Diseases for Middle Ear Squamous Cell Carcinoma

Diseases related to Middle Ear Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 middle ear carcinoma 30.3 RECK GP5
2 bone squamous cell carcinoma 29.7 RECK MMP9 CDKN2A
3 squamous cell carcinoma 10.5
4 bell's palsy 10.3
5 papilloma 10.3
6 otitis media 10.1
7 rapidly involuting congenital hemangioma 10.1
8 otorrhea 10.1
9 cholesteatoma of middle ear 10.1
10 facial paralysis 10.1
11 skin carcinoma 10.1
12 chromoblastomycosis 10.0 MMP9 CCL3
13 tropical spastic paraparesis 10.0 MMP9 CCL3
14 inverted follicular keratosis 10.0 GP6 GP5
15 focal epithelial hyperplasia 10.0 GP6 GP5
16 cervical adenosarcoma 9.9 GP6 GP5
17 proteasome-associated autoinflammatory syndrome 1 9.9 MMP9 CCL3
18 carotid artery disease 9.9 MMP9 GP6
19 neuritis 9.9 MMP9 CCL3
20 glanzmann thrombasthenia 1 9.9 RECK GP6
21 lyme disease 9.9 MMP9 CCL3
22 gray platelet syndrome 9.9 GP6 GP5
23 keratosis 9.9 MMP9 CDKN2A
24 relapsing-remitting multiple sclerosis 9.9 MMP9 CCL3
25 cervical clear cell adenocarcinoma 9.9 GP5 CDKN2A
26 squamous cell papilloma 9.9 GP5 CDKN2A
27 bronchial disease 9.9 MMP9 CCL3
28 penile benign neoplasm 9.9 GP5 CDKN2A
29 lip and oral cavity cancer 9.8 MMP9 CDKN2A
30 male reproductive organ benign neoplasm 9.8 GP5 CDKN2A
31 vaginal cancer 9.8 GP5 CDKN2A
32 phimosis 9.8 GP5 CDKN2A
33 verrucous carcinoma 9.8 GP5 CDKN2A
34 vulva squamous cell carcinoma 9.8 GP5 CDKN2A
35 adenocarcinoma in situ 9.8 GP5 CDKN2A
36 vulvar disease 9.8 GP5 CDKN2A
37 penile disease 9.8 GP5 CDKN2A
38 breast carcinoma in situ 9.8 MMP9 CDKN2A
39 anus disease 9.8 GP5 CDKN2A
40 ductal carcinoma in situ 9.8 MMP9 CDKN2A
41 rectal disease 9.8 GP5 CDKN2A
42 soft palate cancer 9.8 GP6 CDKN2A
43 vulva cancer 9.8 GP5 CDKN2A
44 oropharynx cancer 9.8 GP5 CDKN2A
45 bernard-soulier syndrome 9.8 RECK GP6 GP5
46 blood platelet disease 9.7 RECK GP6 GP5
47 human papillomavirus infectious disease 9.7 GP5 CDKN2A
48 vascular disease 9.7 RECK MMP9 GP6
49 stroke, ischemic 9.7 MMP9 GP6 CCL3
50 cholangiocarcinoma 9.7 RECK MMP9 CDKN2A

Graphical network of the top 20 diseases related to Middle Ear Squamous Cell Carcinoma:



Diseases related to Middle Ear Squamous Cell Carcinoma

Symptoms & Phenotypes for Middle Ear Squamous Cell Carcinoma

Drugs & Therapeutics for Middle Ear Squamous Cell Carcinoma

Search Clinical Trials, NIH Clinical Center for Middle Ear Squamous Cell Carcinoma

Genetic Tests for Middle Ear Squamous Cell Carcinoma

Anatomical Context for Middle Ear Squamous Cell Carcinoma

Organs/tissues related to Middle Ear Squamous Cell Carcinoma:

MalaCards : Bone, Brain

Publications for Middle Ear Squamous Cell Carcinoma

Articles related to Middle Ear Squamous Cell Carcinoma:

(show all 18)
# Title Authors PMID Year
1
Clinical outcomes of temporal bone squamous cell carcinoma: A single-institution experience. 62
36229984 2022
2
The revised Pittsburgh staging system for middle ear squamous cell carcinoma: A challenging clinical dilemma. 62
35384118 2022
3
Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma. 62
34559476 2021
4
HPV Infection in Middle Ear Squamous Cell Carcinoma: Prevalence, Genotyping and Prognostic Impact. 62
33673300 2021
5
Beta human papillomaviruses in middle ear squamous cell carcinoma. 62
30665705 2019
6
Detection of Epstein-Barr and Human Papilloma Viruses in the Middle Ear Squamous Cell Carcinoma. 62
29456946 2018
7
Outcomes of 18 cases with squamous cell carcinoma of middle ear who underwent both surgery and post-operative radiotherapy. 62
26472473 2016
8
Giant middle ear squamous cell carcinoma mimicking as cholesteatoma. 62
22193618 2012
9
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma. 62
22178867 2012
10
[Study on the expression and clinical significance of MMP9 and MVD in the external auditory canal and middle ear squamous cell carcinoma]. 62
21710717 2011
11
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. 62
19381105 2009
12
[Middle ear cancer hidden by chronic otitis media--a case report]. 62
19205537 2008
13
[A case of squamous-cell carcinoma originating in external auditory canal cholesteatoma]. 62
12928719 2003
14
A case of bilateral middle-ear squamous cell carcinoma. 62
11667995 2001
15
Bilateral middle ear squamous cell carcinoma and clinical review of an additional 5 cases of middle ear carcinomas. 62
10077254 1999
16
[Brain abscess as a complication of ear malignancy: a case report]. 62
8851995 1995
17
Bilateral middle-ear squamous cell carcinoma. A case report. 62
3388158 1988
18
Radiotherapy in carcinoma of the middle ear and auditory canal. 62
182892 1976

Variations for Middle Ear Squamous Cell Carcinoma

Expression for Middle Ear Squamous Cell Carcinoma

Search GEO for disease gene expression data for Middle Ear Squamous Cell Carcinoma.

Pathways for Middle Ear Squamous Cell Carcinoma

GO Terms for Middle Ear Squamous Cell Carcinoma

Biological processes related to Middle Ear Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 embryo implantation GO:0007566 9.26 RECK MMP9
2 hemostasis GO:0007599 8.62 GP6 GP5

Sources for Middle Ear Squamous Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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