MCID: MDD005
MIFTS: 26

Middle Lobe Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Middle Lobe Syndrome

MalaCards integrated aliases for Middle Lobe Syndrome:

Name: Middle Lobe Syndrome 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2810
MeSH 44 D008878
SNOMED-CT 67 28295001
UMLS 70 C0026069

Summaries for Middle Lobe Syndrome

Disease Ontology : 12 A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

MalaCards based summary : Middle Lobe Syndrome is related to bronchiectasis and aspergillosis. An important gene associated with Middle Lobe Syndrome is HBD (Hemoglobin Subunit Delta), and among its related pathways/superpathways is Factors involved in megakaryocyte development and platelet production. Affiliated tissues include lung and lymph node.

Related Diseases for Middle Lobe Syndrome

Diseases related to Middle Lobe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 bronchiectasis 10.5
2 aspergillosis 10.2
3 silicosis 10.2
4 allergic bronchopulmonary aspergillosis 10.2
5 bronchitis 10.2
6 mycobacterium tuberculosis 1 10.1
7 bronchiolitis 10.1
8 ige responsiveness, atopic 10.0
9 sarcoidosis 1 10.0
10 pulmonary disease, chronic obstructive 10.0
11 lymphadenitis 10.0
12 amyloidosis 10.0
13 kaposi sarcoma 9.9
14 dowling-degos disease 1 9.9
15 tracheopathia osteoplastica 9.9
16 leprosy 3 9.9
17 osteogenic sarcoma 9.9
18 pulmonary arteriovenous fistulas 9.9
19 lung cancer susceptibility 3 9.9
20 thrombosis 9.9
21 pneumoconiosis 9.9
22 anthracosis 9.9
23 sarcoma 9.9
24 ornithosis 9.9
25 leiomyoma 9.9
26 pulmonary sarcoidosis 9.9
27 squamous cell papilloma 9.9
28 echinococcosis 9.9
29 histoplasmosis 9.9
30 agammaglobulinemia 9.9
31 papilloma 9.9
32 adenocarcinoma 9.9
33 thymic carcinoma 9.9
34 spindle cell sarcoma 9.9
35 bronchiolo-alveolar adenocarcinoma 9.9
36 bronchus adenoma 9.9
37 pneumonia 9.9
38 adenoma 9.9
39 lymph node disease 9.9
40 haemophilus influenzae 9.9
41 hansen's disease 9.9
42 mycobacterium fortuitum 9.9
43 virus-associated trichodysplasia spinulosa 9.9
44 overgrowth syndrome 9.9
45 hemoglobin lepore-beta-thalassemia syndrome 9.9 HBD HBB
46 thalassemia 9.8 HBD HBB
47 thalassemia minor 9.8 HBD HBB
48 hemoglobin d disease 9.8 HBD HBB
49 hemoglobin c disease 9.8 HBD HBB
50 neuropathy, hereditary sensory and autonomic, type iib 9.8 HBD HBB

Graphical network of the top 20 diseases related to Middle Lobe Syndrome:



Diseases related to Middle Lobe Syndrome

Symptoms & Phenotypes for Middle Lobe Syndrome

Drugs & Therapeutics for Middle Lobe Syndrome

Search Clinical Trials , NIH Clinical Center for Middle Lobe Syndrome

Cochrane evidence based reviews: middle lobe syndrome

Genetic Tests for Middle Lobe Syndrome

Anatomical Context for Middle Lobe Syndrome

MalaCards organs/tissues related to Middle Lobe Syndrome:

40
Lung, Lymph Node

Publications for Middle Lobe Syndrome

Articles related to Middle Lobe Syndrome:

(show top 50) (show all 275)
# Title Authors PMID Year
1
68Ga-PSMA Uptake in Middle Lobe Syndrome. 61
30036250 2018
2
Bronchial anthracofibrosis: The spectrum of radiological appearances. 61
30319212 2018
3
Non-Obstructive Middle Lobe Syndrome: An Unusual Cause of Recurrent Pneumonia in an Elderly Woman. 61
30755973 2018
4
Concurrent thymic carcinoma and middle lobe syndrome. 61
29600097 2018
5
Middle lobe syndrome: An exceptional presentation of concomitant lepidic adenocarcinoma and bronchial anthracofibrosis. 61
29424200 2017
6
Right middle lobe torsion after right upper lobectomy in a patient with an undiagnosed middle lobe syndrome. 61
27707504 2017
7
A case of upper left extremity deep vein thrombosis with right side middle lobe syndrome. 61
28974915 2017
8
Long-term Outcome of Short Metallic Stents for Lobar Airway Stenosis. 61
28696967 2017
9
Middle lobe syndrome: an intriguing presentation of tracheobronchial amyloidosis. 61
28536221 2017
10
A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome. 61
27807707 2017
11
Tracheobronchopathia osteochondroplastica - a 61-year-old female with middle lobe syndrome. 61
28667658 2017
12
The concomitant occurrence of pulmonary tuberculosis with bronchial anthracofibrosis. 61
28166918 2017
13
Infectious Causes of Right Middle Lobe Syndrome. 61
28178715 2017
14
Image Diagnosis: Endobronchial Tuberculosis Masquerading as an Endobronchial Tumor with Presentation as Middle Lobe Syndrome. 61
28080949 2017
15
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. 61
27764010 2016
16
Middle lobe syndrome: a singularly rare presentation of complicated pulmonary hydatid disease. 61
27045051 2016
17
Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome. 61
26844222 2016
18
[The middle lobe syndrome]. 61
26509560 2015
19
Experiences and challenges of thorcoscopic lung surgery in the pediatric age group. 61
26475091 2015
20
Ten years' experience in surgical treatment of right middle lobe syndrome. 61
25753209 2015
21
Middle lobe syndrome: an extraordinary presentation of endobronchial tuberculosis. 61
26379001 2015
22
Secretory hyperresponsiveness and pulmonary mucus hypersecretion. 61
25091755 2014
23
Middle lobe syndrome due to calcified adenopathy. 61
24712018 2014
24
Middle lobe syndrome: a rare presentation of allergic bronchopulmonary aspergillosis. 61
25053632 2014
25
Middle lobe syndrome in children today. 61
24630779 2014
26
Broncholithiasis with recurrent lithoptysis: a case report. 61
23949189 2014
27
Clinical profile of recurrent community-acquired pneumonia in children. 61
24106756 2013
28
Chest MR imaging in the follow-up of pulmonary alterations in paediatric patients with middle lobe syndrome: comparison with chest X-ray. 61
23090250 2013
29
Middle lobe syndrome associated with major haemoptysis. 61
23587098 2013
30
Causes of recurrent pneumonia in children in a general hospital. 61
23438187 2013
31
Bronchoscopic evaluation of unexplained recurrent and persistent pneumonia in children. 61
23438344 2013
32
An incidental and uncommon pulmonary sequestration with an uncommon feeding artery. 61
23959421 2013
33
Chronic atelectasis of the left lower lobe: a clinicopathological condition equivalent to middle lobe syndrome. 61
22761114 2012
34
Surgical treatment of right middle lobe syndrome in children. 61
22347343 2012
35
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment. 61
22377566 2012
36
[A case of a carcinoid tumour presenting as an "upper lobe syndrome"]. 61
22123146 2011
37
Thoracoscopic lobectomy as a treatment option for persistent middle lobe syndrome in children. 61
20500467 2010
38
Naxos disease in two siblings. 61
21188028 2010
39
Middle lobe syndrome in the left lower lobe in chronic obstructive pulmonary disease. 61
19517049 2009
40
Endobronchial tuberculosis with lobar obstruction successfully treated by argon plasma coagulation. 61
19738520 2009
41
[Pulmonary function of children with right lung middle lobe syndrome]. 61
19695198 2009
42
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment. 61
20298381 2009
43
Chyloptysis with right middle lobe syndrome complicated postoperatively by chylothorax: an unusual cause of right middle lobe syndrome. 61
19399303 2009
44
Endobronchial tuberculosis presenting as right middle lobe syndrome: clinical characteristics and bronchoscopic findings in 22 cases. 61
18729304 2008
45
Massive benign pericardial cyst presenting with simultaneous superior vena cava and middle lobe syndromes. 61
18495035 2008
46
[Clinical analysis of thoracoscopic lobectomy: a report of 40 cases]. 61
18785570 2008
47
Bronchial anthracofibrosis and tuberculosis presenting as a middle lobe syndrome. 61
18253679 2008
48
[A case of primary Sjögren's syndrome presenting with middle lobe syndrome complicated by nontuberculous mycobacteriosis]. 61
18260312 2008
49
Tracheo-broncho-bronchiolar lesions in Sjögren's syndrome. 61
18197930 2008
50
[Thoracoscopic anatomical lung resection in children]. 61
17610198 2007

Variations for Middle Lobe Syndrome

Expression for Middle Lobe Syndrome

Search GEO for disease gene expression data for Middle Lobe Syndrome.

Pathways for Middle Lobe Syndrome

Pathways related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 HBD HBB

GO Terms for Middle Lobe Syndrome

Cellular components related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 9.16 HBD HBB
2 blood microparticle GO:0072562 9.13 HBD HBB CFB
3 haptoglobin-hemoglobin complex GO:0031838 8.62 HBD HBB

Biological processes related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.63 DEFB104B DEFB104A CFB
2 defense response GO:0006952 9.48 DEFB104B DEFB104A
3 defense response to Gram-positive bacterium GO:0050830 9.43 DEFB104B DEFB104A
4 defense response to Gram-negative bacterium GO:0050829 9.4 DEFB104B DEFB104A
5 cellular oxidant detoxification GO:0098869 9.37 HBD HBB
6 positive chemotaxis GO:0050918 9.32 DEFB104B DEFB104A
7 monocyte chemotaxis GO:0002548 9.26 DEFB104B DEFB104A
8 hydrogen peroxide catabolic process GO:0042744 9.16 HBD HBB
9 oxygen transport GO:0015671 8.96 HBD HBB
10 cellular response to phorbol 13-acetate 12-myristate GO:1904628 8.62 DEFB104B DEFB104A

Molecular functions related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 HBD HBB
2 peroxidase activity GO:0004601 9.4 HBD HBB
3 chemoattractant activity GO:0042056 9.37 DEFB104B DEFB104A
4 oxygen binding GO:0019825 9.32 HBD HBB
5 oxygen carrier activity GO:0005344 9.26 HBD HBB
6 organic acid binding GO:0043177 9.16 HBD HBB
7 haptoglobin binding GO:0031720 8.96 HBD HBB
8 hemoglobin alpha binding GO:0031721 8.62 HBD HBB

Sources for Middle Lobe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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