MCID: MDD005
MIFTS: 21

Middle Lobe Syndrome

Categories: Respiratory diseases

Aliases & Classifications for Middle Lobe Syndrome

MalaCards integrated aliases for Middle Lobe Syndrome:

Name: Middle Lobe Syndrome 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2810
MeSH 45 D008878
SNOMED-CT 69 28295001
UMLS 74 C0026069

Summaries for Middle Lobe Syndrome

Disease Ontology : 12 A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

MalaCards based summary : Middle Lobe Syndrome is related to aspergillosis and allergic bronchopulmonary aspergillosis. An important gene associated with Middle Lobe Syndrome is BANF1 (Barrier To Autointegration Factor 1), and among its related pathways/superpathways is Circadian entrainment. Affiliated tissues include lung, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Middle Lobe Syndrome

Diseases related to Middle Lobe Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 10.1
2 allergic bronchopulmonary aspergillosis 10.1
3 asthma 10.0
4 sarcoma 9.9
5 ige responsiveness, atopic 9.8
6 kaposi sarcoma 9.8
7 tracheopathia osteoplastica 9.8
8 lung cancer 9.8
9 osteogenic sarcoma 9.8
10 sjogren syndrome 9.8
11 pulmonary disease, chronic obstructive 9.8
12 silicosis 9.8
13 sinusitis 9.8
14 thrombosis 9.8
15 ornithosis 9.8
16 squamous cell papilloma 9.8
17 histoplasmosis 9.8
18 papilloma 9.8
19 adenocarcinoma 9.8
20 thymic carcinoma 9.8
21 pneumonia 9.8
22 amyloidosis 9.8
23 mycobacterium fortuitum 9.8
24 male reproductive organ cancer 9.7 FOLH1 VEGFA
25 male reproductive system disease 9.6 FOLH1 VEGFA
26 reproductive system disease 9.5 FOLH1 VEGFA

Graphical network of the top 20 diseases related to Middle Lobe Syndrome:



Diseases related to Middle Lobe Syndrome

Symptoms & Phenotypes for Middle Lobe Syndrome

GenomeRNAi Phenotypes related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.4 BANF1 VEGFA
2 Increased Nanog expression GR00371-A-2 9.4 VEGFA
3 Increased Nanog expression GR00371-A-4 9.4 VEGFA
4 Increased Nanog expression GR00371-A-5 9.4 BANF1 VEGFA

Drugs & Therapeutics for Middle Lobe Syndrome

Search Clinical Trials , NIH Clinical Center for Middle Lobe Syndrome

Cochrane evidence based reviews: middle lobe syndrome

Genetic Tests for Middle Lobe Syndrome

Anatomical Context for Middle Lobe Syndrome

MalaCards organs/tissues related to Middle Lobe Syndrome:

42
Lung

Publications for Middle Lobe Syndrome

Articles related to Middle Lobe Syndrome:

(show top 50) (show all 110)
# Title Authors Year
1
Concurrent thymic carcinoma and middle lobe syndrome. ( 29600097 )
2018
2
68Ga-PSMA Uptake in Middle Lobe Syndrome. ( 30036250 )
2018
3
Non-Obstructive Middle Lobe Syndrome: An Unusual Cause of Recurrent Pneumonia in an Elderly Woman. ( 30755973 )
2018
4
Middle lobe syndrome: an intriguing presentation of tracheobronchial amyloidosis. ( 28536221 )
2017
5
Right middle lobe torsion after right upper lobectomy in a patient with an undiagnosed middle lobe syndrome. ( 27707504 )
2017
6
A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome. ( 27807707 )
2017
7
Image Diagnosis: Endobronchial Tuberculosis Masquerading as an Endobronchial Tumor with Presentation as Middle Lobe Syndrome. ( 28080949 )
2017
8
Infectious Causes of Right Middle Lobe Syndrome. ( 28178715 )
2017
9
Tracheobronchopathia osteochondroplastica - a 61-year-old female with middle lobe syndrome. ( 28667658 )
2017
10
A case of upper left extremity deep vein thrombosis with right side middle lobe syndrome. ( 28974915 )
2017
11
Middle lobe syndrome: An exceptional presentation of concomitant lepidic adenocarcinoma and bronchial anthracofibrosis. ( 29424200 )
2017
12
Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome. ( 26844222 )
2016
13
Middle lobe syndrome: a singularly rare presentation of complicated pulmonary hydatid disease. ( 27045051 )
2016
14
Endobronchial Silicosis and Tuberculosis Presenting as the Right Middle Lobe Syndrome. ( 27764010 )
2016
15
Ten years' experience in surgical treatment of right middle lobe syndrome. ( 25753209 )
2015
16
Middle lobe syndrome: an extraordinary presentation of endobronchial tuberculosis. ( 26379001 )
2015
17
Middle lobe syndrome: a rare presentation of allergic bronchopulmonary aspergillosis. ( 25053632 )
2014
18
Middle lobe syndrome in children today. ( 24630779 )
2014
19
Middle lobe syndrome due to calcified adenopathy. ( 24712018 )
2014
20
Chest MR imaging in the follow-up of pulmonary alterations in paediatric patients with middle lobe syndrome: comparison with chest X-ray. ( 23090250 )
2013
21
Middle lobe syndrome associated with major haemoptysis. ( 23587098 )
2013
22
Surgical treatment of right middle lobe syndrome in children. ( 22347343 )
2012
23
Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment. ( 22377566 )
2012
24
Chronic atelectasis of the left lower lobe: a clinicopathological condition equivalent to middle lobe syndrome. ( 22761114 )
2012
25
Thoracoscopic lobectomy as a treatment option for persistent middle lobe syndrome in children. ( 20500467 )
2010
26
Chyloptysis with right middle lobe syndrome complicated postoperatively by chylothorax: an unusual cause of right middle lobe syndrome. ( 19399303 )
2009
27
Middle lobe syndrome in the left lower lobe in chronic obstructive pulmonary disease. ( 19517049 )
2009
28
Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment. ( 20298381 )
2009
29
Bronchial anthracofibrosis and tuberculosis presenting as a middle lobe syndrome. ( 18253679 )
2008
30
Endobronchial tuberculosis presenting as right middle lobe syndrome: clinical characteristics and bronchoscopic findings in 22 cases. ( 18729304 )
2008
31
Bronchial hyperresponsiveness in persistent middle lobe syndrome in childhood. ( 17256771 )
2007
32
Middle lobe syndrome as the pulmonary manifestation of primary Sjögren's syndrome. ( 16548837 )
2006
33
Lung cancer arising in association with middle lobe syndrome. ( 16821589 )
2006
34
Editorial: respecting the middle lobe syndrome. ( 16845655 )
2006
35
Bronchial hyperresponsiveness, atopy, and bronchoalveolar lavage eosinophils in persistent middle lobe syndrome. ( 16845656 )
2006
36
The role of timely intervention in middle lobe syndrome in children. ( 16236916 )
2005
37
Middle lobe syndrome in children with asthma: review of 56 cases. ( 15281327 )
2004
38
Improvement in right lung atelectasis (middle lobe syndrome) following administration of low-dose roxithromycin. ( 11287839 )
2001
39
Kaposi's sarcoma: another cause of middle lobe syndrome. ( 11705444 )
2001
40
Middle lobe syndrome due to obstructing solitary bronchial papilloma. ( 10630661 )
1999
41
The right middle-lobe syndrome--a case report and review of the literature. ( 9107229 )
1997
42
Not the right middle lobe syndrome? ( 9254755 )
1997
43
Middle lobe syndrome. ( 8644568 )
1996
44
Case report: Blastomyces dermatitidis as a cause of middle lobe syndrome. ( 8853069 )
1996
45
Outcome after right middle lobe syndrome. ( 7606950 )
1995
46
Middle lobe syndrome: a clinicopathological study of 21 patients. ( 7890282 )
1995
47
Allergic bronchopulmonary aspergillosis with middle lobe syndrome and allergic Aspergillus sinusitis. ( 8339813 )
1993
48
Role of infection in the middle lobe syndrome in asthma. ( 1599294 )
1992
49
Right middle lobe syndrome caused by Mycobacterium fortuitum in a patient with human immunodeficiency virus infection. ( 1631699 )
1992
50
Clinical findings in middle lobe syndrome and other processes of pulmonary shrinkage in children (atelectasis syndrome). ( 1747357 )
1991

Variations for Middle Lobe Syndrome

Expression for Middle Lobe Syndrome

Search GEO for disease gene expression data for Middle Lobe Syndrome.

Pathways for Middle Lobe Syndrome

Pathways related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 FOLH1 VEGFA

GO Terms for Middle Lobe Syndrome

Cellular components related to Middle Lobe Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.62 FOLH1 VEGFA

Sources for Middle Lobe Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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