FHM1
MCID: MGR032
MIFTS: 40

Migraine, Familial Hemiplegic, 1 (FHM1)

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Migraine, Familial Hemiplegic, 1

MalaCards integrated aliases for Migraine, Familial Hemiplegic, 1:

Name: Migraine, Familial Hemiplegic, 1 57 74 13
Fhm1 57 12 53 74
Mhp1 57 12 53 74
Familial Hemiplegic Migraine Type 1 53 29 6
Hemiplegic Migraine, Familial Type 1 53 72
Fhm 57 74
Migraine, Familial Hemiplegic, 1, with Progressive Cerebellar Ataxia 57
Migraine, Familial Hemiplegic 1, with Progressive Cerebellar Ataxia 53
Familial Hemiplegic Migraine1 with Progressive Cerebellar Ataxia 12
Migraine Familial Hemiplegic with Progressive Cerebellar Ataxia 74
Migraine, Hemiplegic, Familial, Type 1 40
Familial Hemiplegic Migraine 1 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
genetic heterogeneity
subtype of migraine with aura
onset 5-30 years
symptoms usually last 30-60 minutes
pulsatile headache lasts hours to days
in severe attacks, hemiplegia or coma may last days to weeks
triggered by minor head trauma
marked clinical variability within families
allelic disorder to episodic ataxia-2 (ea2, ) and spinocerebellar ataxia-6 (sca6, )


HPO:

32
migraine, familial hemiplegic, 1:
Inheritance autosomal dominant inheritance heterogeneous


Classifications:



External Ids:

Disease Ontology 12 DOID:0111181
OMIM 57 141500
MeSH 44 D020325
UMLS 72 C1832884

Summaries for Migraine, Familial Hemiplegic, 1

NIH Rare Diseases : 53 Familial hemiplegic migraine (FHM) is an inherited form of hemiplegic migraine. Hemiplegic migraine is a type of migraine with aura that causes motor impairment (such as weakness) in addition to at least one visual, sensory, or speech disturbance (aura) that occurs before the migraine headache begins. FHM commonly begins during childhood or adolescence. The symptoms of FHM can be scary and distressing. FHM is currently classified into 4 subtypes, distinguished by their genetic cause: FHM type 1 (the most common type) is caused by mutations in the CACNA1A gene and is commonly associated with cerebellar degeneration. FHM type 2 is caused by mutations in the ATP1A2 gene and may be associated with seizures. FHM type 3 is caused by mutations in the SCN1A gene. FHM type 4 is diagnosed if no mutation currently known to cause FHM can be identified. Inheritance of FHM is autosomal dominant, but not everyone who inherits a mutation responsible for FHM will have symptoms (a phenomenon called reduced penetrance). The diagnosis of FHM requires that at least one first- or second-degree relative has also been diagnosed with hemiplegic migraine. Tests such as a CT scan or MRI of the brain, cerebrospinal fluid analysis, and EEG may be needed to rule out other potential causes of headache and neurological symptoms. Genetic testing may confirm the subtype of FHM in a family. Treatment of hemiplegic migraine involves medications to alleviate pain, stop the migraines, and prevent future migraines. Severe headache attacks may require hospitalization. In most people with hemiplegic migraines, aura symptoms completely go away in between migraines and the migraines become less frequent with age. Rarely, hemiplegic migraines may cause permanent neurological symptoms, cognitive impairment, stroke, coma, or death.

MalaCards based summary : Migraine, Familial Hemiplegic, 1, also known as fhm1, is related to migraine with or without aura 1 and alternating hemiplegia of childhood 1, and has symptoms including fever, hemiplegia and hemiparesis. An important gene associated with Migraine, Familial Hemiplegic, 1 is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A). The drugs Nitroglycerin and Salmon Calcitonin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are seizures and tremor

Disease Ontology : 12 A familial hemiplegic migraine that is commonly associated with cerebellar degeneration and has material basis in heterozygous mutation in CACNA1A on 19p13.

UniProtKB/Swiss-Prot : 74 Migraine, familial hemiplegic, 1: A subtype of migraine with aura associated with ictal hemiparesis and, in some families, cerebellar ataxia and atrophy. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.

More information from OMIM: 141500

Related Diseases for Migraine, Familial Hemiplegic, 1

Graphical network of the top 20 diseases related to Migraine, Familial Hemiplegic, 1:



Diseases related to Migraine, Familial Hemiplegic, 1

Symptoms & Phenotypes for Migraine, Familial Hemiplegic, 1

Human phenotypes related to Migraine, Familial Hemiplegic, 1:

32 (show all 21)
# Description HPO Frequency HPO Source Accession
1 seizures 32 occasional (7.5%) HP:0001250
2 tremor 32 occasional (7.5%) HP:0001337
3 nystagmus 32 HP:0000639
4 ataxia 32 HP:0001251
5 dysphasia 32 HP:0002357
6 fever 32 HP:0001945
7 anxiety 32 HP:0000739
8 migraine 32 HP:0002076
9 psychosis 32 HP:0000709
10 agitation 32 HP:0000713
11 confusion 32 HP:0001289
12 visual hallucinations 32 HP:0002367
13 coma 32 HP:0001259
14 cerebellar atrophy 32 HP:0001272
15 hemiplegia 32 HP:0002301
16 hemiparesis 32 HP:0001269
17 drowsiness 32 HP:0002329
18 dyscalculia 32 HP:0002442
19 auditory hallucinations 32 HP:0008765
20 transient unilateral blurring of vision 32 HP:0001125
21 migraine with aura 32 HP:0002077

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
dysphasia
migraine
confusion
hemiplegia
hemiparesis
more
Neurologic Behavioral Psychiatric Manifestations:
visual hallucinations
auditory hallucinations
anxiety attacks
paranoid psychosis

Metabolic Features:
fever

Head And Neck Eyes:
hemianopic blurring of vision
nystagmus (may be permanent in 50% of patients)

Clinical features from OMIM:

141500

UMLS symptoms related to Migraine, Familial Hemiplegic, 1:


fever, hemiplegia, hemiparesis, cerebellar ataxia, hallucinations, auditory, hallucinations, visual

Drugs & Therapeutics for Migraine, Familial Hemiplegic, 1

Drugs for Migraine, Familial Hemiplegic, 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational 55-63-0 4510
2
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
3
Calcium Approved, Nutraceutical 7440-70-2 271
4
Calcitonin gene-related peptide Investigational 83652-28-2
5 Vasodilator Agents
6 Hormones
7 Katacalcin
8 Calcium, Dietary
9 calcitonin
10 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 Completed NCT00257985 GTN
2 Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. Completed NCT00358839 CGRP

Search NIH Clinical Center for Migraine, Familial Hemiplegic, 1

Genetic Tests for Migraine, Familial Hemiplegic, 1

Genetic tests related to Migraine, Familial Hemiplegic, 1:

# Genetic test Affiliating Genes
1 Familial Hemiplegic Migraine Type 1 29 CACNA1A

Anatomical Context for Migraine, Familial Hemiplegic, 1

MalaCards organs/tissues related to Migraine, Familial Hemiplegic, 1:

41
Brain, Testes, Bone, Cerebellum, Trigeminal Ganglion

Publications for Migraine, Familial Hemiplegic, 1

Articles related to Migraine, Familial Hemiplegic, 1:

(show top 50) (show all 132)
# Title Authors PMID Year
1
Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. 8 71
12056940 2002
2
Recurrence of the T666M calcium channel CACNA1A gene mutation in familial hemiplegic migraine with progressive cerebellar ataxia. 8 71
9915947 1999
3
Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. 8 71
8898206 1996
4
Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. 8 71
8734765 1996
5
Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. 38 71
19586927 2009
6
Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. 38 8
19104150 2009
7
CACNA1A R1347Q: a frequent recurrent mutation in hemiplegic migraine. 38 71
18400034 2008
8
Gating deficiency in a familial hemiplegic migraine type 1 mutant P/Q-type calcium channel. 38 71
15795222 2005
9
Familial Hemiplegic Migraine 38 71
20301562 2001
10
De novo mutations in epileptic encephalopathies. 71
23934111 2013
11
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. 8
20837964 2010
12
EFNS guidelines on the molecular diagnosis of channelopathies, epilepsies, migraine, stroke, and dementias. 71
20298421 2010
13
Calcitonin gene-related peptide does not cause the familial hemiplegic migraine phenotype. 8
18779512 2008
14
Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation. 71
18313928 2008
15
1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1. 8
15728280 2005
16
Childhood epilepsy, familial hemiplegic migraine, cerebellar ataxia, and a new CACNA1A mutation. 71
15452324 2004
17
A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. 8
15003170 2004
18
Expanding the phenotypic spectrum of the CACNA1A gene T666M mutation: a description of 5 families with familial hemiplegic migraine. 71
12756131 2003
19
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. 71
12707077 2003
20
Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine. 71
11409427 2001
21
Missense CACNA1A mutation causing episodic ataxia type 2. 71
11176968 2001
22
CACNA1A gene de novo mutation causing hemiplegic migraine, coma, and cerebellar atrophy. 71
11061267 2000
23
Detection of a novel missense mutation and second recurrent mutation in the CACNA1A gene in individuals with EA-2 and FHM. 71
10987655 1999
24
Genetic heterogeneity in Italian families with familial hemiplegic migraine. 71
10408532 1999
25
A new CACNA1A gene mutation in acetazolamide-responsive familial hemiplegic migraine and ataxia. 71
10408534 1999
26
Familial hemiplegic migraine with cerebellar ataxia and paroxysmal psychosis. 8
10202246 1999
27
Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine. 8
9708761 1998
28
Identification of a key recombinant narrows the CADASIL gene region to 8 cM and argues against allelism of CADASIL and familial hemiplegic migraine. 8
8786108 1996
29
Exocytotic Ca2+ channels in mammalian central neurons. 71
7537420 1995
30
Familial hemiplegic migraine versus migraine with prolonged aura: an uncertain diagnosis in a family report. 8
7824130 1995
31
Genetic heterogeneity of familial hemiplegic migraine. 8
7977376 1994
32
Familial migraine: exclusion of the susceptibility gene from the reported locus of familial hemiplegic migraine on 19p. 8
7851903 1994
33
Genetic heterogeneity of familial hemiplegic migraine. 8
7959770 1994
34
A gene for familial hemiplegic migraine maps to chromosome 19. 8
8220421 1993
35
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12. 8
8485581 1993
36
Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. 8
1727198 1992
37
Familial migraine coma: a case study. 8
2319269 1990
38
Familial hemiplegic migraine. 8
1127995 1975
39
[Familial hemiplegic migraine associated with nystagmus]. 8
5159359 1971
40
Familial hemiplegic migraine, retinal degeneration, deafness, and nystagmus. 8
5311627 1970
41
Familial occurrence of migraine with a hemiplegic syndrome and cerebellar manifestations. 8
15088544 1967
42
HEMIPLEGIC MIGRAINE, A CLINICAL STUDY. 8
14252427 1965
43
Familial hemiplegic migraine. 8
13854572 1960
44
Familial hemiplegic migraine. 8
13272341 1955
45
On Recurrent Motor Paralysis in Migraine, with Report of a Family in which Recurrent Hemiplegia Accompanied the Attacks. 8
20765161 1910
46
Basal astrocyte and microglia activation in the central nervous system of Familial Hemiplegic Migraine Type I mice. 38
31260335 2019
47
Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans. 38
31364988 2019
48
Relief Following Chronic Stress Augments Spreading Depolarization Susceptibility in Familial Hemiplegic Migraine Mice. 38
31299346 2019
49
Trigeminovascular calcitonin gene-related peptide function in Cacna1a R192Q-mutated knock-in mice. 38
28792272 2019
50
The neuropsychiatric phenotype in CACNA1A mutations: a retrospective single center study and review of the literature. 38
30063100 2019

Variations for Migraine, Familial Hemiplegic, 1

ClinVar genetic disease variations for Migraine, Familial Hemiplegic, 1:

6 (show all 48)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CACNA1A NM_001127221.1(CACNA1A): c.4046G> A (p.Arg1349Gln) single nucleotide variant Pathogenic rs1057520918 19:13373594-13373594 19:13262780-13262780
2 CACNA1A NM_001127221.1(CACNA1A): c.575G> A (p.Arg192Gln) single nucleotide variant Pathogenic rs121908211 19:13482558-13482558 19:13371744-13371744
3 CACNA1A NM_001127221.1(CACNA1A): c.1997C> T (p.Thr666Met) single nucleotide variant Pathogenic rs121908212 19:13414691-13414691 19:13303877-13303877
4 CACNA1A NM_001127221.1(CACNA1A): c.2141T> C (p.Val714Ala) single nucleotide variant Pathogenic rs121908213 19:13414394-13414394 19:13303580-13303580
5 CACNA1A NM_001127221.1(CACNA1A): c.5428A> C (p.Ile1810Leu) single nucleotide variant Pathogenic rs121908214 19:13340999-13340999 19:13230185-13230185
6 CACNA1A NM_001127221.1(CACNA1A): c.2145C> A (p.Asp715Glu) single nucleotide variant Pathogenic rs121908218 19:13414390-13414390 19:13303576-13303576
7 CACNA1A NM_001127221.1(CACNA1A): c.4151A> G (p.Tyr1384Cys) single nucleotide variant Pathogenic rs121908219 19:13372366-13372366 19:13261552-13261552
8 CACNA1A NM_001127221.1(CACNA1A): c.4366G> T (p.Val1456Leu) single nucleotide variant Pathogenic rs121908237 19:13370403-13370403 19:13259589-13259589
9 CACNA1A NM_001127221.1(CACNA1A): c.653C> T (p.Ser218Leu) single nucleotide variant Pathogenic rs121908225 19:13476262-13476262 19:13365448-13365448
10 CACNA1A NM_001127221.1(CACNA1A): c.1748G> A (p.Arg583Gln) single nucleotide variant Pathogenic rs121908217 19:13419266-13419266 19:13308452-13308452
11 CACNA1A NM_001127221.1(CACNA1A): c.5126T> C (p.Ile1709Thr) single nucleotide variant Pathogenic rs121909326 19:13346033-13346033 19:13235219-13235219
12 CACNA1A NM_001127221.1(CACNA1A): c.4037G> A (p.Arg1346Gln) single nucleotide variant Pathogenic rs121908230 19:13373603-13373603 19:13262789-13262789
13 CACNA1A NC_000019.10 deletion Pathogenic 19:13317256-13335480 19:13206442-13224666
14 CACNA1A NC_000019.10 deletion Pathogenic 19:13317256-13335480 19:13206442-13224666
15 CACNA1A NM_001127221.1(CACNA1A): c.4999C> T (p.Arg1667Trp) single nucleotide variant Pathogenic rs121908220 19:13346499-13346499 19:13235685-13235685
16 CACNA1A NM_001127221.1(CACNA1A): c.2137G> A (p.Ala713Thr) single nucleotide variant Pathogenic/Likely pathogenic rs886037945 19:13414398-13414398 19:13303584-13303584
17 CACNA1A NM_001127221.1(CACNA1A): c.4636C> T (p.Arg1546Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121909324 19:13366031-13366031 19:13255217-13255217
18 CACNA1A NM_001127221.1(CACNA1A): c.1060C> T (p.Leu354Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs1555767914 19:13446642-13446642 19:13335828-13335828
19 CACNA1A NM_001127221.1(CACNA1A): c.4177G> A (p.Val1393Met) single nucleotide variant Conflicting interpretations of pathogenicity rs794727411 19:13372340-13372340 19:13261526-13261526
20 CACNA1A NM_001127221.1(CACNA1A): c.593G> A (p.Arg198Gln) single nucleotide variant Uncertain significance rs797045424 19:13482540-13482540 19:13371726-13371726
21 CACNA1A NM_001127221.1(CACNA1A): c.6611A> G (p.Lys2204Arg) single nucleotide variant Uncertain significance rs1057521770 19:13319742-13319742 19:13208928-13208928
22 CACNA1A NM_001127221.1(CACNA1A): c.6434C> T (p.Pro2145Leu) single nucleotide variant Uncertain significance rs750077868 19:13320221-13320221 19:13209407-13209407
23 CACNA1A NM_001127221.1(CACNA1A): c.2893C> T (p.Pro965Ser) single nucleotide variant Uncertain significance rs1383144531 19:13409557-13409557 19:13298743-13298743
24 CACNA1A NM_001127221.1(CACNA1A): c.2927G> T (p.Arg976Leu) single nucleotide variant Uncertain significance rs748418783 19:13409523-13409523 19:13298709-13298709
25 CACNA1A NM_001127221.1(CACNA1A): c.2108-15C> T single nucleotide variant Uncertain significance rs190471428 19:13414442-13414442 19:13303628-13303628
26 CACNA1A NM_001127221.1(CACNA1A): c.689G> T (p.Gly230Val) single nucleotide variant Uncertain significance 19:13476226-13476226 19:13365412-13365412
27 CACNA1A NM_001127221.1(CACNA1A): c.6128C> T (p.Thr2043Met) single nucleotide variant Uncertain significance rs563345694 19:13323262-13323262 19:13212448-13212448
28 CACNA1A NM_001127221.1(CACNA1A): c.6508C> T (p.Arg2170Cys) single nucleotide variant Uncertain significance rs375354077 19:13320147-13320147 19:13209333-13209333
29 CACNA1A NM_001127221.1(CACNA1A): c.6469C> T (p.Arg2157Cys) single nucleotide variant Uncertain significance rs554393704 19:13320186-13320186 19:13209372-13209372
30 CACNA1A NM_001127221.1(CACNA1A): c.3413C> G (p.Pro1138Arg) single nucleotide variant Uncertain significance rs200333359 19:13397460-13397460 19:13286646-13286646
31 CACNA1A NM_001127221.1(CACNA1A): c.3637G> T (p.Asp1213Tyr) single nucleotide variant Uncertain significance rs201269793 19:13395940-13395940 19:13285126-13285126
32 CACNA1A NM_001127221.1(CACNA1A): c.1348+7C> T single nucleotide variant Benign/Likely benign rs192536793 19:13441051-13441051 19:13330237-13330237
33 CACNA1A NM_001127221.1(CACNA1A): c.2754G> C (p.Glu918Asp) single nucleotide variant Benign rs16022 19:13409696-13409696 19:13298882-13298882
34 CACNA1A NM_001127221.1(CACNA1A): c.2978A> T (p.Glu993Val) single nucleotide variant Benign rs16023 19:13409472-13409472 19:13298658-13298658
35 CACNA1A NM_001127221.1(CACNA1A): c.3313G> A (p.Gly1105Ser) single nucleotide variant Benign rs16027 19:13397560-13397560 19:13286746-13286746
36 CACNA1A NM_001127221.1(CACNA1A): c.3549C> T (p.Val1183=) single nucleotide variant Benign rs16029 19:13397324-13397324 19:13286510-13286510
37 CACNA1A NM_001127221.1(CACNA1A): c.2094G> A (p.Thr698=) single nucleotide variant Benign rs16016 19:13414594-13414594 19:13303780-13303780
38 CACNA1A NM_001127221.1(CACNA1A): c.3060G> A (p.Arg1020=) single nucleotide variant Benign rs16025 19:13409390-13409390 19:13298576-13298576
39 CACNA1A NM_001127221.1(CACNA1A): c.3864T> C (p.Phe1288=) single nucleotide variant Benign rs16030 19:13387904-13387904 19:13277090-13277090
40 CACNA1A NM_001127221.1(CACNA1A): c.462C> T (p.Ala154=) single nucleotide variant Benign rs1800039 19:13563767-13563767 19:13452953-13452953
41 CACNA1A NM_001127221.1(CACNA1A): c.5742C> T (p.Ala1914=) single nucleotide variant Benign rs16044 19:13325415-13325415 19:13214601-13214601
42 CACNA1A NM_001127221.1(CACNA1A): c.579G> A (p.Thr193=) single nucleotide variant Benign rs41276894 19:13482554-13482554 19:13371740-13371740
43 CACNA1A NM_001127221.1(CACNA1A): c.876A> G (p.Glu292=) single nucleotide variant Benign rs16006 19:13470522-13470522 19:13359708-13359708
44 CACNA1A NM_001127221.1(CACNA1A): c.4003A> G (p.Lys1335Glu) single nucleotide variant not provided rs121908223 19:13373637-13373637 19:13262823-13262823
45 CACNA1A NM_001127221.1(CACNA1A): c.2145C> G (p.Asp715Glu) single nucleotide variant not provided rs121908218 19:13414390-13414390 19:13303576-13303576
46 CACNA1A NM_001127221.1(CACNA1A): c.5047T> C (p.Trp1683Arg) single nucleotide variant not provided rs121908221 19:13346451-13346451 19:13235637-13235637
47 CACNA1A NM_001127221.1(CACNA1A): c.5083G> A (p.Val1695Ile) single nucleotide variant not provided rs121908224 19:13346076-13346076 19:13235262-13235262
48 CACNA1A NM_001127221.1(CACNA1A): c.584G> A (p.Arg195Lys) single nucleotide variant not provided rs121908222 19:13482549-13482549 19:13371735-13371735

UniProtKB/Swiss-Prot genetic disease variations for Migraine, Familial Hemiplegic, 1:

74 (show all 15)
# Symbol AA change Variation ID SNP ID
1 CACNA1A p.Arg192Gln VAR_001491 rs121908211
2 CACNA1A p.Thr665Met VAR_001492 rs121908212
3 CACNA1A p.Val713Ala VAR_001493 rs121908213
4 CACNA1A p.Ile1809Leu VAR_001494 rs121908214
5 CACNA1A p.Arg195Lys VAR_043820 rs121908222
6 CACNA1A p.Ser218Leu VAR_043821 rs121908225
7 CACNA1A p.Arg582Gln VAR_043826 rs121908217
8 CACNA1A p.Asp714Glu VAR_043827 rs121908218
9 CACNA1A p.Lys1334Glu VAR_043829 rs121908223
10 CACNA1A p.Arg1345Gln VAR_043830 rs121908230
11 CACNA1A p.Tyr1383Cys VAR_043831 rs121908219
12 CACNA1A p.Val1455Leu VAR_043833 rs121908237
13 CACNA1A p.Arg1666Trp VAR_043838 rs121908220
14 CACNA1A p.Trp1682Arg VAR_043839 rs121908221
15 CACNA1A p.Val1694Ile VAR_063706 rs121908224

Expression for Migraine, Familial Hemiplegic, 1

Search GEO for disease gene expression data for Migraine, Familial Hemiplegic, 1.

Pathways for Migraine, Familial Hemiplegic, 1

GO Terms for Migraine, Familial Hemiplegic, 1

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