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MCID: MGR030
MIFTS: 32
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Migraine, Familial Hemiplegic, 2
Categories:
Genetic diseases, Rare diseases, Neuronal diseases
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MalaCards integrated aliases for Migraine, Familial Hemiplegic, 2:
Characteristics:OMIM:57
Inheritance:
autosomal dominant
Miscellaneous:
onset 6 to 30 years highly variable frequency and duration of episodes headaches last hours to days neurologic signs last hours to days episodes may be triggered by exercise, emotional stress, head trauma, angiography, lack of sleep, heat reduced penetrance (approximately 87%) genetic heterogeneity (see fhm1 ) alternating hemiplegia of childhood is an allelic disorder with an overlapping phenotype HPO:32
migraine, familial hemiplegic, 2:
Onset and clinical course incomplete penetrance Inheritance heterogeneous autosomal dominant inheritance Classifications: |
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NIH Rare Diseases
:
53
Familial hemiplegic migraine (FHM) is a form of migraine headache that runs in families. Migraines usually cause intense, throbbing pain in one area of the head, often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. These recurrent headaches typically begin in childhood or adolescence and may last from a few hours to a few days. People with familial hemiplegic migraine experience an aura that comes before the headache. The most common symptoms associated with an aura are temporary visual changes such as blind spots (scotomas), flashing lights, zig-zagging lines, and double vision. In people with familial hemiplegic migraine, auras are also characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). An aura typically develops gradually over a few minutes and lasts about an hour. Researchers have identified three forms of familial hemiplegic migraine known as FHM1, FHM2, and FHM3. Each of the three types is caused by mutations in a different gene. Treatment varies depending on signs and symptoms and may include use of anti migraine or anti seizure medications.
MalaCards based summary : Migraine, Familial Hemiplegic, 2, also known as migraine, familial basilar, is related to familial hemiplegic migraine and migraine, familial hemiplegic, 1, and has symptoms including fever, hemiparesis and hemiplegia. An important gene associated with Migraine, Familial Hemiplegic, 2 is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). Affiliated tissues include brain and smooth muscle, and related phenotypes are diplopia and intellectual disability UniProtKB/Swiss-Prot : 75 Migraine, familial hemiplegic, 2: A subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.
Description from OMIM:
602481
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Diseases in the Hemiplegic Migraine family:
Diseases related to Migraine, Familial Hemiplegic, 2 via text searches within MalaCards or GeneCards Suite gene sharing:
Graphical network of the top 20 diseases related to Migraine, Familial Hemiplegic, 2:
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Symptoms via clinical synopsis from OMIM:57Clinical features from OMIM:602481Human phenotypes related to Migraine, Familial Hemiplegic, 2:32 (show all 18)
UMLS symptoms related to Migraine, Familial Hemiplegic, 2:fever, hemiparesis, hemiplegia |
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MalaCards organs/tissues related to Migraine, Familial Hemiplegic, 2:41
Brain,
Smooth Muscle
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Articles related to Migraine, Familial Hemiplegic, 2:(show all 16)
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Genes related to Migraine, Familial Hemiplegic, 2 (1 elite genes):
- Elite gene
- Cancer Census gene in COSMIC
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UniProtKB/Swiss-Prot genetic disease variations for Migraine, Familial Hemiplegic, 2:75
ClinVar genetic disease variations for Migraine, Familial Hemiplegic, 2:6
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Search
GEO
for disease gene expression data for Migraine, Familial Hemiplegic, 2.
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