MBA
MCID: MGR035
MIFTS: 21

Migraine with Brainstem Aura (MBA)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Name: Migraine with Brainstem Aura 53
Basilar-Type Migraine 53 73
Basilar Migraine 53 55
Vertebrobasilar Migraine 53
Basilar Artery Migraine 53
Bickerstaff Migraine 53
Brainstem Migraine 53
Mba 53

Classifications:



External Ids:

UMLS 73 C0270860

Summaries for Migraine with Brainstem Aura

NIH Rare Diseases : 53 Migraine with brainstem aura (MBA) is a type of migraine headache with aura that is associated with pain at the back of the head on both sides. An aura is a group of symptoms that generally serve as a warning sign that a bad headache is coming. Auras may consist of dizziness and vertigo, slurred speech, ataxia, tinnitus, visual changes, and/or loss of balance. Although MBA can occur in men and women of all ages, they are most common in adolescent girls. The exact underlying cause of MBA is poorly understood. Migraines are likely complex disorders that are influenced by multiple genes, in combination with lifestyle and environmental factors. In rare cases, susceptibility to MBA may be caused by a change (mutation) in the ATP1A2 gene or CACNA1A gene. Treatment during an episode may include nonsteroidal anti-inflammatory drugs (NSAIDs) and antiemetic medications to help ease the symptoms.

MalaCards based summary : Migraine with Brainstem Aura, also known as basilar-type migraine, is related to migraine, familial hemiplegic, 2 and kleine-levin hibernation syndrome. An important gene associated with Migraine with Brainstem Aura is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). The drugs Topiramate and Neuroprotective Agents have been mentioned in the context of this disorder.

Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 migraine, familial hemiplegic, 2 11.6
2 kleine-levin hibernation syndrome 10.1
3 recurrent hypersomnia 10.1
4 hypersomnia 10.1
5 arts syndrome 10.1
6 osteoarthritis 10.1
7 clubfoot 10.1
8 episodic ataxia, type 2 10.0
9 medulloblastoma 10.0
10 paraganglioma 10.0
11 episodic ataxia 10.0
12 headache 10.0
13 familial hemiplegic migraine 10.0
14 locked-in syndrome 10.0
15 hemiplegic migraine 10.0
16 cardiac arrhythmia 9.9
17 viral meningitis 9.9
18 transient global amnesia 9.9
19 lateral medullary syndrome 9.9
20 meningitis 9.9
21 encephalitis 9.9
22 chiari malformation 9.9

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:



Diseases related to Migraine with Brainstem Aura

Symptoms & Phenotypes for Migraine with Brainstem Aura

Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2, Phase 3 97240-79-4 5284627
2 Neuroprotective Agents Phase 2, Phase 3
3 Anticonvulsants Phase 2, Phase 3
4 Anti-Obesity Agents Phase 2, Phase 3
5 Protective Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00131443 Phase 2, Phase 3 Topiramate
2 A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00158002 Phase 2 Topiramate
3 Continuous Treatment Study of Topiramate in Migraine Participants Completed NCT01799590 Phase 2 Topiramate

Search NIH Clinical Center for Migraine with Brainstem Aura

Genetic Tests for Migraine with Brainstem Aura

Anatomical Context for Migraine with Brainstem Aura

Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

(show all 23)
# Title Authors Year
1
Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report. ( 29694468 )
2018
2
Basilar-type migraine: An overlooked cause of loss of consciousness in pediatric emergency rooms. ( 28890047 )
2018
3
Migraine with brainstem aura: Why not a cortical origin? ( 29073774 )
2017
4
Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). ( 27343267 )
2016
5
A Valuable Case for Recognizing the Relationship between Arrhythmia and the Biology of Migraine with Brainstem Aura. ( 27404408 )
2016
6
Clinical characteristics of basilar-type migraine in the neurological clinic of a university hospital. ( 24666545 )
2014
7
Unrecognized Paraganglioma of the Urinary Bladder as a Cause for Basilar-Type Migraine. ( 23735539 )
2013
8
Basilar-type migraine patients responsive to lamotrigine: a 5-year follow-up. ( 23695071 )
2013
9
Vertebrobasilar dolichoectasia causing a presentation resembling basilar-type migraine. ( 22877683 )
2013
10
Ventricular tachycardia during basilar-type migraine attack. ( 23277791 )
2013
11
Basilar-type migraine with coma: case reports and literature review. ( 21463463 )
2011
12
Acute treatment of basilar-type migraine with greater occipital nerve blockade. ( 20487035 )
2010
13
CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. ( 19486177 )
2009
14
Relationship between basilar-type migraine and migrainous vertigo. ( 19178580 )
2009
15
Basilar-type migraine. ( 19457282 )
2009
16
Pontine capillary telangiectasia as visualized on MR imaging causing a clinical picture resembling basilar-type migraine: a case report. ( 19533201 )
2009
17
ATP1A2 gene mutations are not present in two sisters with basilar-type migraine associated with menses. ( 18483709 )
2008
18
Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. ( 18644040 )
2008
19
Basilar artery fenestration in a woman with basilar-type migraine. ( 17464479 )
2007
20
Basilar-type migraine responsive to lamotrigine: three case reports. ( 17508181 )
2007
21
A double-blind, dose comparison study of topiramate for prophylaxis of basilar-type migraine in children: a pilot study. ( 18052950 )
2007
22
Basilar-type migraine: clinical, epidemiologic, and genetic features. ( 16567706 )
2006
23
Medulloblastoma induces unusual headache with clinical picture of basilar-type migraine complicated by ischaemic infarcts. ( 16961793 )
2006

Variations for Migraine with Brainstem Aura

Expression for Migraine with Brainstem Aura

Search GEO for disease gene expression data for Migraine with Brainstem Aura.

Pathways for Migraine with Brainstem Aura

GO Terms for Migraine with Brainstem Aura

Sources for Migraine with Brainstem Aura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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