Migraine with Brainstem Aura disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MBA MCID: MGR035 MIFTS: 20	Migraine with Brainstem Aura (MBA) Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Name: Migraine with Brainstem Aura ²⁰

Basilar-Type Migraine ²⁰ ⁷⁰

Basilar Migraine ²⁰ ⁵⁴

Vertebrobasilar Migraine ²⁰

Basilar Artery Migraine ²⁰

Bickerstaff Migraine ²⁰

Brainstem Migraine ²⁰

Mba ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷⁰ C0270860

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Summaries for Migraine with Brainstem Aura

GARD : ²⁰ Migraine with brainstem aura (MBA) is a type of migraine headache with aura that is associated with pain at the back of the head on both sides. An aura is a group of symptoms that generally serve as a warning sign that a bad headache is coming. Auras may consist of dizziness and vertigo, slurred speech, ataxia, tinnitus, visual changes, and/or loss of balance. Although MBA can occur in men and women of all ages, they are most common in adolescent girls. The exact underlying cause of MBA is poorly understood. Migraines are likely complex disorders that are influenced by multiple genes, in combination with lifestyle and environmental factors. In rare cases, susceptibility to MBA may be caused by a change ( mutation ) in the ATP1A2 gene or CACNA1A gene. Treatment during an episode may include nonsteroidal anti-inflammatory drugs (NSAIDs) and antiemetic medications to help ease the symptoms.

MalaCards based summary : Migraine with Brainstem Aura, also known as basilar-type migraine, is related to migraine, familial hemiplegic, 2 and migraine with or without aura 1. An important gene associated with Migraine with Brainstem Aura is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). The drugs Topiramate and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include cerebellum.

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Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)

#	Related Disease	Score
1	migraine, familial hemiplegic, 2	11.2
2	migraine with or without aura 1	10.5
3	migraine with aura	10.4
4	ataxia and polyneuropathy, adult-onset	10.3
5	headache	10.3
6	osteoarthritis	10.2
7	ocular motor apraxia	10.2
8	pathologic nystagmus	10.2
9	kleine-levin hibernation syndrome	10.1
10	recurrent hypersomnia	10.1
11	hypersomnia	10.1
12	breast cancer	10.1
13	seizure disorder	10.0
14	48,xyyy	10.0
15	kearns-sayre syndrome	10.0
16	yemenite deaf-blind hypopigmentation syndrome	10.0
17	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	10.0
18	familial hemiplegic migraine	10.0
19	hydrocephalus	10.0
20	amnestic disorder	10.0
21	locked-in syndrome	10.0
22	migraine without aura	10.0
23	transient global amnesia	10.0
24	demyelinating disease	10.0
25	retrograde amnesia	10.0
26	whiplash	10.0
27	rare headache	10.0
28	episodic ataxia, type 2	10.0
29	paragangliomas 4	10.0
30	cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	10.0
31	migraine, familial hemiplegic, 1	10.0
32	medulloblastoma	10.0
33	motion sickness	10.0
34	pheochromocytoma	10.0
35	torticollis	10.0
36	gastrointestinal stromal tumor	10.0
37	migraine, familial hemiplegic, 3	10.0
38	developmental and epileptic encephalopathy 42	10.0
39	paraganglioma	10.0
40	telangiectasis	10.0
41	neuroendocrine tumor	10.0
42	sleep disorder	10.0
43	barre-lieou syndrome	10.0
44	episodic ataxia	10.0
45	hereditary paraganglioma-pheochromocytoma syndromes	10.0
46	nonsyndromic paraganglioma	10.0
47	autonomic dysfunction	10.0
48	benign paroxysmal torticollis of infancy	10.0
49	cardiac arrhythmia	9.9
50	chiari malformation type ii	9.9

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:

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Symptoms & Phenotypes for Migraine with Brainstem Aura

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Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Topiramate

Approved

Phase 2, Phase 3

97240-79-4

5284627

Synonyms:

.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)

[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate

2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamic acid

2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamic acid

2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamic acid

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamic acid

2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamic acid

2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

2,3-4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.

97240-79-4

AKOS000424547

beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate

beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate

BIDD:GT0854

BIDD:PXR0127

BRN 5988957

BSPBio_002306

C052342

C07502

C12H21NO8S

CBChromo1_000352

CHEBI:129573

CHEMBL220492

CID5284627

Cilag brand of topiramate

CPD000466325

D00537

DB00273

-D-fructopyranose deriv.

Epitoma

Epitomax

HMS1922H06

HMS2051L09

HMS2093D20

HSDB 7531

Janssen brand of topiramate

KS-1122

KW-6485

LS-187392

LS-69764

McN 4853

McN-4853

MCN-4853

MLS000759431

MLS001424070

MolPort-001-615-062

MolPort-002-885-869

NCGC00178714-01

Ortho brand of topiramate

RWJ 17021

RWJ-17021

RWJ-17021-000

S1438_Selleck

SAM001246601

SMR000466325

SPBio_000995

SPECTRUM1505801

Spectrum2_001128

STOCK1N-71037

T0575_SIGMA

Tipiramate

Tipiramate [French]

Tipiramato

Tipiramato [Spanish]

Tipiramic acid

TL8006021

Topamac

Topamax

Topamax (TN)

Topamax sprinkle

Topamax Sprinkle

Topamax, Topiramate

Topimax

Topina

topiramate

Topiramate

Topiramate (JAN/USAN/INN)

Topiramate (TPM)

Topiramate / Placebo

Topiramate [USAN:BAN:INN]

topiramate tablet

Topiramato

Topiramato [INN-Spanish]

Topiramatum

Topiramatum [INN-Latin]

topiramatum [Latin]

Topiramic acid

Topomax

TOR

TPM

Trokendi XR

UNII-0H73WJJ391

USL-255

Anticonvulsants

Phase 2, Phase 3

Hypoglycemic Agents

Phase 2, Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Double-Blind Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine	Completed	NCT00131443	Phase 2, Phase 3	Topiramate
2	An Open-Label Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine	Completed	NCT00158002	Phase 2	Topiramate

Search NIH Clinical Center for Migraine with Brainstem Aura

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Genetic Tests for Migraine with Brainstem Aura

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Anatomical Context for Migraine with Brainstem Aura

MalaCards organs/tissues related to Migraine with Brainstem Aura:

⁴⁰

Cerebellum

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Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

(show top 50) (show all 69)

#	Title	Authors	PMID	Year
1	Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability. ⁶¹	Imbrici P...D'Adamo MC	32394190	2020
2	How to define migraine with brainstem aura? ⁶¹	Lempert T...Seemungal BM	32282900	2020
3	Migraine Aura: Updates in Pathophysiology and Management. ⁶¹	Lai J...Dilli E	32430657	2020
4	Neuroimaging for Migraine: The American Headache Society Systematic Review and Evidence-Based Guideline. ⁶¹	Evans RW...Turner DP	31891197	2020
5	Migraine with brainstem aura: defining the core syndrome. ⁶¹	Yamani N...Olesen J	31789370	2019
6	Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk. ⁶¹	Mathew PG...Klein BC	31318457	2019
7	A singular association of migraine with brainstem aura and Alice in Wonderland syndrome. ⁶¹	Chirchiglia D...Marotta R	31049666	2019
8	Vestibular Migraine: How to Sort it Out and What to Do About it. ⁶¹	Beh SC	31094996	2019
9	Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks. ⁶¹	Vgontzas A...Burch R	30291554	2018
10	Migraine with brainstem aura: Why not a cortical origin? ⁶¹	Demarquay G...Mauguiere F	29073774	2018
11	Basilar-type migraine: An overlooked cause of loss of consciousness in pediatric emergency rooms. ⁶¹	Chou IC...Hong SY	28890047	2018
12	Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report. ⁶¹	Rossi FH...Tsakadze N	29694468	2018
13	Paranasal Sinus Disease in Children With Headache. ⁶¹	Vieira Neto RJ...Montenegro MA	28831857	2017
14	Possible Involvement of the CACNA1E Gene in Migraine: A Search for Single Nucleotide Polymorphism in Different Clinical Phenotypes. ⁶¹	Ambrosini A...Schoenen J	28573794	2017
15	Migraine with Aura or Sports-Related Concussion: Case Report, Pathophysiology, and Multidisciplinary Approach to Management. ⁶¹	Ellis MJ...Johnston J	28067735	2017
16	Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). ⁶¹	Nesbitt AD...Leschziner GD	27343267	2016
17	Complicated Migraines. ⁶¹	Blumenfeld AE...Berenson FR	27017017	2016
18	A Valuable Case for Recognizing the Relationship between Arrhythmia and the Biology of Migraine with Brainstem Aura. ⁶¹	Yao G...Zhang XM	27404408	2016
19	Unique Migraine Subtypes, Rare Headache Disorders, and Other Disturbances. ⁶¹	Goadsby PJ	26252589	2015
20	Field-testing of the ICHD-3 beta/proposed ICD-11 diagnostic criteria for migraine with aura. ⁶¹	Li D...Olesen J	25424707	2015
21	Greater Occipital Nerve Blockade: A Safe and Effective Option for the Acute Treatment of Hemiplegic Aura. ⁶¹	Casas-Limon J...Cuadrado ML	26140423	2015
22	Clinical characteristics of basilar-type migraine in the neurological clinic of a university hospital. ⁶¹	Ying G...Zhou J	24666545	2014
23	[Basilar type migraine: clinical features, differential diagnosis]. ⁶¹	Stulin ID...Tardova IM	24662337	2014
24	Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. ⁶¹	Taghdiri F...Refaeian F	24834377	2014
25	[Cochleovestibular disorders in the patients suffering from migraine of the basilar type]. ⁶¹	Kunel'skaia NL...Zaoeva ZO	25734300	2014
26	Unrecognized paraganglioma of the urinary bladder as a cause for basilar-type migraine. ⁶¹	Pichler R...Steiner H	23735539	2014
27	Migraine variants--occurrence in pediatric neurology practice. ⁶¹	Pacheva IH...Ivanov IS	23688445	2013
28	Vertebrobasilar dolichoectasia causing a presentation resembling basilar-type migraine. ⁶¹	Huang L...Wang Y	22877683	2013
29	Basilar-type migraine patients responsive to lamotrigine: a 5-year follow-up. ⁶¹	Cologno D...Bussone G	23695071	2013
30	[Migraine with prolonged atypical aura: report of two cases]. ⁶¹	Coban A	23588869	2013
31	Ventricular tachycardia during basilar-type migraine attack. ⁶¹	Pitarokoili K...Krogias C	23277791	2013
32	[Migraine associated with conversion symptoms (Babinski's migraine): evaluation of a series of 43 cases]. ⁶¹	Garcia-Albea E	21889233	2012
33	A curiosity in the history of sciences: the words "megrim" and "migraine". ⁶¹	Lardreau E	22239094	2012
34	Primary headache disorders and neuro-ophthalmologic manifestations. ⁶¹	Schwartz DP...Robbins MS	28539781	2012
35	Migraine with binocular blindness: a clinic-based study. ⁶¹	Rozen TD	21812773	2011
36	Basilar-type migraine with coma: case reports and literature review. ⁶¹	Li Q...Zhou J	21463463	2011
37	Vertebral artery dissection presented as lateral medullary syndrome in a patient with migraine: a case report. ⁶¹	Yen JC...Lai YJ	21210329	2010
38	Dihydroergotamine and its use in migraine with posterior fossa symptoms. ⁶¹	Whyte CA...Tepper SJ	20533960	2010
39	Acute treatment of basilar-type migraine with greater occipital nerve blockade. ⁶¹	Baron EP...Cherian N	20487035	2010
40	Migraine with aura with onset in childhood and adolescence: long-term natural history and prognostic factors. ⁶¹	Termine C...Balottin U	20511205	2010
41	Migraine-associated psychosis and subsequent renal transplant. ⁶¹	Bourgeois J...Mistry H	20118445	2010
42	Vestibular migraine. ⁶¹	Strupp M...Brandt T	20816468	2010
43	Pontine capillary telangiectasia as visualized on MR imaging causing a clinical picture resembling basilar-type migraine: a case report. ⁶¹	Beukers RJ...Roos YB	19533201	2009
44	[Vestibular migraine]. ⁶¹	Lempert T	19629427	2009
45	CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. ⁶¹	Robbins MS...Grosberg BM	19486177	2009
46	Basilar-type migraine. ⁶¹	Kaniecki RG	19457282	2009
47	Pediatric migraine. ⁶¹	Lewis DW	19289227	2009
48	Vertigo as a symptom of migraine. ⁶¹	Lempert T...Daroff RB	19645907	2009
49	Infant brain stem is prone to the generation of spreading depression during severe hypoxia. ⁶¹	Funke F...Muller M	19261708	2009
50	"Vestibular migraine": effects of prophylactic therapy with various drugs. A retrospective study. ⁶¹	Baier B...Dieterich M	19266150	2009

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Genes for Migraine with Brainstem Aura

Genes related to Migraine with Brainstem Aura (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ATP1A2	ATPase Na+/K+ Transporting Subunit Alpha 2	Protein Coding	9.23	Novoseek inferred ⁵⁴	16344534

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Variations for Migraine with Brainstem Aura

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Expression for Migraine with Brainstem Aura

Search GEO for disease gene expression data for Migraine with Brainstem Aura.

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Pathways for Migraine with Brainstem Aura

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GO Terms for Migraine with Brainstem Aura

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Sources for Migraine with Brainstem Aura

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Migraine with Brainstem Aura (MBA)

Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Classifications:

External Ids:

Summaries for Migraine with Brainstem Aura

Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:

Symptoms & Phenotypes for Migraine with Brainstem Aura

Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Migraine with Brainstem Aura

Anatomical Context for Migraine with Brainstem Aura

MalaCards organs/tissues related to Migraine with Brainstem Aura:

Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

Genes for Migraine with Brainstem Aura

Genes related to Migraine with Brainstem Aura (0 elite genes):

Variations for Migraine with Brainstem Aura

Expression for Migraine with Brainstem Aura

Pathways for Migraine with Brainstem Aura

GO Terms for Migraine with Brainstem Aura

Sources for Migraine with Brainstem Aura