Migraine with Brainstem Aura disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Name: Migraine with Brainstem Aura ⁵³

Basilar-Type Migraine ⁵³ ⁷³

Basilar Migraine ⁵³ ⁵⁵

Vertebrobasilar Migraine ⁵³

Basilar Artery Migraine ⁵³

Bickerstaff Migraine ⁵³

Brainstem Migraine ⁵³

Mba ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷³ C0270860

Sources

Summaries for Migraine with Brainstem Aura

NIH Rare Diseases : ⁵³ Migraine with brainstem aura (MBA) is a type of migraine headache with aura that is associated with pain at the back of the head on both sides. An aura is a group of symptoms that generally serve as a warning sign that a bad headache is coming. Auras may consist of dizziness and vertigo, slurred speech, ataxia, tinnitus, visual changes, and/or loss of balance. Although MBA can occur in men and women of all ages, they are most common in adolescent girls. The exact underlying cause of MBA is poorly understood. Migraines are likely complex disorders that are influenced by multiple genes, in combination with lifestyle and environmental factors. In rare cases, susceptibility to MBA may be caused by a change (mutation) in the ATP1A2 gene or CACNA1A gene. Treatment during an episode may include nonsteroidal anti-inflammatory drugs (NSAIDs) and antiemetic medications to help ease the symptoms.

MalaCards based summary : Migraine with Brainstem Aura, also known as basilar-type migraine, is related to migraine, familial hemiplegic, 2 and osteoarthritis. An important gene associated with Migraine with Brainstem Aura is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). The drugs Topiramate and Neuroprotective Agents have been mentioned in the context of this disorder.

Sources

Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)

#	Related Disease	Score
1	migraine, familial hemiplegic, 2	11.4
2	osteoarthritis	10.0
3	recurrent hypersomnia	10.0
4	hypersomnia	10.0
5	kleine-levin hibernation syndrome	10.0
6	episodic ataxia	9.9
7	episodic ataxia, type 2	9.9
8	paraganglioma	9.9
9	hemiplegic migraine	9.9
10	familial hemiplegic migraine	9.9
11	locked-in syndrome	9.9
12	chiari malformation type ii	9.8

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:

Sources

Symptoms & Phenotypes for Migraine with Brainstem Aura

Sources

Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Topiramate

Approved

Phase 2, Phase 3

97240-79-4

5284627

Synonyms:

.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)

[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate

2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamic acid

2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamic acid

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamic acid

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamic acid

2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

2,3-4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.

97240-79-4

AKOS000424547

beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate

beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate

BIDD:GT0854

BIDD:PXR0127

BRN 5988957

BSPBio_002306

C052342

C07502

C12H21NO8S

CBChromo1_000352

CHEBI:129573

CHEMBL220492

CID5284627

Cilag brand of topiramate

CPD000466325

D00537

DB00273

-D-fructopyranose deriv.

Epitoma

Epitomax

HMS1922H06

HMS2051L09

HMS2093D20

HSDB 7531

Janssen brand of topiramate

KS-1122

KW-6485

LS-187392

LS-69764

McN 4853

McN-4853

MCN-4853

MLS000759431

MLS001424070

MolPort-001-615-062

MolPort-002-885-869

NCGC00178714-01

Ortho brand of topiramate

RWJ 17021

RWJ-17021

RWJ-17021-000

S1438_Selleck

SAM001246601

SMR000466325

SPBio_000995

SPECTRUM1505801

Spectrum2_001128

STOCK1N-71037

T0575_SIGMA

Tipiramate

Tipiramate [French]

Tipiramato

Tipiramato [Spanish]

Tipiramic acid

TL8006021

Topamac

Topamax

Topamax (TN)

Topamax sprinkle

Topamax Sprinkle

Topamax, Topiramate

Topimax

Topina

topiramate

Topiramate

Topiramate (JAN/USAN/INN)

Topiramate (TPM)

Topiramate / Placebo

Topiramate [USAN:BAN:INN]

topiramate tablet

Topiramato

Topiramato [INN-Spanish]

Topiramatum

Topiramatum [INN-Latin]

topiramatum [Latin]

Topiramic acid

Topomax

TOR

TPM

UNII-0H73WJJ391

USL-255

2

Neuroprotective Agents

Phase 2, Phase 3

3

Anticonvulsants

Phase 2, Phase 3

4

Anti-Obesity Agents

Phase 2, Phase 3

5

Protective Agents

Phase 2, Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine	Completed	NCT00131443	Phase 2, Phase 3	Topiramate
2	A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine	Completed	NCT00158002	Phase 2	Topiramate
3	Continuous Treatment Study of Topiramate in Migraine Participants	Completed	NCT01799590	Phase 2	Topiramate

Search NIH Clinical Center for Migraine with Brainstem Aura

Sources

Genetic Tests for Migraine with Brainstem Aura

Sources

Anatomical Context for Migraine with Brainstem Aura

Sources

Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

(show all 11)

#	Title	Authors	Year
1	Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report. ( 29694468 )	Rossi F.H....Tsakadze N.	2018
2	Migraine with brainstem aura: Why not a cortical origin? ( 29073774 )	Demarquay G....Mauguiere F.	2017
3	Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). ( 27343267 )	Nesbitt A.D....Leschziner G.D.	2016
4	A Valuable Case for Recognizing the Relationship between Arrhythmia and the Biology of Migraine with Brainstem Aura. ( 27404408 )	Yao G....Zhang X.M.	2016
5	Unrecognized Paraganglioma of the Urinary Bladder as a Cause for Basilar-Type Migraine. ( 23735539 )	Pichler R....Steiner H.	2013
6	Basilar-type migraine patients responsive to lamotrigine: a 5-year follow-up. ( 23695071 )	Cologno D....Bussone G.	2013
7	Basilar-type migraine with coma: case reports and literature review. ( 21463463 )	Li Q....Zhou J.	2011
8	CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. ( 19486177 )	Robbins M.S....Grosberg B.M.	2009
9	ATP1A2 gene mutations are not present in two sisters with basilar-type migraine associated with menses. ( 18483709 )	Cologno D....Bussone G.	2008
10	Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. ( 18644040 )	Cuenca-LeA^n E....Cormand B.	2008
11	Basilar-type migraine: clinical, epidemiologic, and genetic features. ( 16567706 )	Kirchmann M....Olesen J.	2006

Sources

Genes for Migraine with Brainstem Aura

Genes related to Migraine with Brainstem Aura (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ATP1A2	ATPase Na+/K+ Transporting Subunit Alpha 2	Protein Coding	19.23	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	16344534

Sources

Variations for Migraine with Brainstem Aura

Sources

Expression for Migraine with Brainstem Aura

Search GEO for disease gene expression data for Migraine with Brainstem Aura.

Sources

Pathways for Migraine with Brainstem Aura

Sources

GO Terms for Migraine with Brainstem Aura

Sources

Sources for Migraine with Brainstem Aura

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia