Migraine with Brainstem Aura disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Name: Migraine with Brainstem Aura ¹⁹

Basilar-Type Migraine ¹⁹ ⁷¹

Basilar Migraine ¹⁹ ⁵³

Mba ¹⁹ ⁷⁵

Vertebrobasilar Migraine ¹⁹

Basilar Artery Migraines ⁷⁵

Basilar Artery Migraine ¹⁹

Bickerstaff Migraine ¹⁹

Brainstem Migraine ¹⁹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷¹ C0270860

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Summaries for Migraine with Brainstem Aura

GARD: ¹⁹ Migraine with brainstem aura (MBA) is a type of migraine headache with aura that is associated with pain at the back of the head on both sides. An aura is a group of symptoms that generally serve as a warning sign that a bad headache is coming. Auras may consist of dizziness and vertigo, slurred speech, ataxia, tinnitus, visual changes, and/or loss of balance. The exact underlying cause of MBA is poorly understood. Migraines are likely complex disorders that are influenced by multiple genes, in combination with lifestyle and environmental factors. In rare cases, susceptibility to MBA may be caused by a change in the ATP1A2 gene or CACNA1A gene.

MalaCards based summary: Migraine with Brainstem Aura, also known as basilar-type migraine, is related to migraine, familial hemiplegic, 2 and migraine with or without aura 1. An important gene associated with Migraine with Brainstem Aura is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). The drugs Topiramate and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include occipital lobe, trigeminal ganglion and pons.

Wikipedia ⁷⁵ Basilar artery migraines: Migraine (UK: /ˈmiːɡreɪn/, US: /ˈmaɪ-/) is a common neurological disorder characterized by recurrent... more...

Mba: MBA is Master of Business Administration, a master's... more...

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Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)

#	Related Disease	Score
1	migraine, familial hemiplegic, 2	11.2
2	migraine with or without aura 1	10.6
3	migraine with aura	10.4
4	headache	10.4
5	immunodeficiency, common variable, 10	10.3
6	fetal anticonvulsant syndrome	10.2
7	pathologic nystagmus	10.2
8	kleine-levin hibernation syndrome	10.1
9	ocular motor apraxia	10.1
10	cranioectodermal dysplasia	10.1
11	recurrent hypersomnia	10.1
12	idiopathic hypersomnia	10.1
13	hypersomnia	10.1
14	bacteremia 2	10.1
15	non-alcoholic steatohepatitis	10.1
16	visual epilepsy	10.1
17	kearns-sayre syndrome	10.0
18	familial hemiplegic migraine	10.0
19	hydrocephalus	10.0
20	amnestic disorder	10.0
21	locked-in syndrome	10.0
22	migraine without aura	10.0
23	transient global amnesia	10.0
24	inner ear disease	10.0
25	demyelinating disease	10.0
26	retrograde amnesia	10.0
27	whiplash	10.0
28	rare headache	10.0
29	breast cancer	10.0
30	down syndrome	10.0
31	48,xyyy	10.0
32	episodic ataxia, type 2	10.0
33	paragangliomas 4	10.0
34	cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	10.0
35	migraine, familial hemiplegic, 1	10.0
36	medulloblastoma	10.0
37	meniere disease	10.0
38	motion sickness	10.0
39	pheochromocytoma	10.0
40	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	10.0
41	torticollis	10.0
42	mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	10.0
43	gastrointestinal stromal tumor	10.0
44	migraine, familial hemiplegic, 3	10.0
45	developmental and epileptic encephalopathy 42	10.0
46	paraganglioma	10.0
47	telangiectasis	10.0
48	neuroendocrine tumor	10.0
49	sleep disorder	10.0
50	barre-lieou syndrome	10.0

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:

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Symptoms & Phenotypes for Migraine with Brainstem Aura

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Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Topiramate

Approved

Phase 2, Phase 3

97240-79-4

5284627

Synonyms:

[(1R,2S,6S,9R)-4,4,11,11-TETRAMETHYL-3,5,7,10,12-PENTAOXATRICYCLO[7.3.0.0^{2,6}]DODECAN-6-YL]METHYL SULFAMATE

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamic acid

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamate

2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamic acid

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamic acid

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamic acid

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamic acid

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamate

2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamic acid

2,3-4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate

Epitomax

epitomax|Eprontia® (liquid formulation)|MCN-4853|RWJ-17021|Topamax®

MCN-4853

QUDEXY XR

RWJ-17021

RWJ-17021-000

Tipiramate

Tipiramate [French]

Tipiramato

Tipiramato [Spanish]

Tipiramic acid

Topamax

Topamax sprinkle

TOPIRAMATE

topiramate tablet

Topiramato

Topiramato [INN-Spanish]

Topiramatum

Topiramatum [INN-Latin]

Topiramic acid

Topomax

TPM

Trokendi XR

USL255

USL-255

2

Anticonvulsants

Phase 2, Phase 3

3

Hypoglycemic Agents

Phase 2, Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Double-Blind Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine	Completed	NCT00131443	Phase 2, Phase 3	Topiramate
2	An Open-Label Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine	Completed	NCT00158002	Phase 2	Topiramate

Search NIH Clinical Center for Migraine with Brainstem Aura

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Genetic Tests for Migraine with Brainstem Aura

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Anatomical Context for Migraine with Brainstem Aura

Organs/tissues related to Migraine with Brainstem Aura:

MalaCards : Occipital Lobe, Trigeminal Ganglion, Pons, Brain, Cerebellum, Heart

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Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

(show top 50) (show all 248)

#	Title	Authors	PMID	Year
1	Familial basilar migraine associated with a new mutation in the ATP1A2 gene. ⁵³ ⁶²	Ambrosini A...Pierelli F	16344534	2005
2	Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature. ⁶²	Batum M...Mavioglu H	33045894	2022
3	Vertebrobasilar artery elongation in migraine-a retrospective cross-sectional study. ⁶²	Hensel O...Naegel S	35906498	2022
4	Update on diagnosis and differential diagnosis of vestibular migraine. ⁶²	Shen Y...Qi X	35015204	2022
5	Migraine with Brainstem Aura Accompanied by Disorders of Consciousness. ⁶²	Xu SY...Li CX	33907459	2021
6	Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability. ⁶²	Imbrici P...D'Adamo MC	32394190	2020
7	Migraine Aura: Updates in Pathophysiology and Management. ⁶²	Lai J...Dilli E	32430657	2020
8	How to define migraine with brainstem aura? ⁶²	Lempert T...Seemungal BM	32282900	2020
9	Neuroimaging for Migraine: The American Headache Society Systematic Review and Evidence-Based Guideline. ⁶²	Evans RW...Turner DP	31891197	2020
10	Migraine with brainstem aura: defining the core syndrome. ⁶²	Yamani N...Olesen J	31789370	2019
11	Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk. ⁶²	Mathew PG...Klein BC	31318457	2019
12	A singular association of migraine with brainstem aura and Alice in Wonderland syndrome. ⁶²	Chirchiglia D...Marotta R	31049666	2019
13	Vestibular Migraine: How to Sort it Out and What to Do About it. ⁶²	Beh SC	31094996	2019
14	Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks. ⁶²	Vgontzas A...Burch R	30291554	2018
15	Migraine with brainstem aura: Why not a cortical origin? ⁶²	Demarquay G...Mauguiere F	29073774	2018
16	Basilar-type migraine: An overlooked cause of loss of consciousness in pediatric emergency rooms. ⁶²	Chou IC...Hong SY	28890047	2018
17	Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report. ⁶²	Rossi FH...Tsakadze N	29694468	2018
18	Paranasal Sinus Disease in Children With Headache. ⁶²	Vieira Neto RJ...Montenegro MA	28831857	2017
19	Possible Involvement of the CACNA1E Gene in Migraine: A Search for Single Nucleotide Polymorphism in Different Clinical Phenotypes. ⁶²	Ambrosini A...Schoenen J	28573794	2017
20	Migraine with Aura or Sports-Related Concussion: Case Report, Pathophysiology, and Multidisciplinary Approach to Management. ⁶²	Ellis MJ...Johnston J	28067735	2017
21	Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). ⁶²	Nesbitt AD...Leschziner GD	27343267	2016
22	A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. ⁶²	Mathew PG...Klein BC	27062528	2016
23	Complicated Migraines. ⁶²	Blumenfeld AE...Berenson FR	27017017	2016
24	A Valuable Case for Recognizing the Relationship between Arrhythmia and the Biology of Migraine with Brainstem Aura. ⁶²	Yao G...Zhang XM	27404408	2016
25	Field-testing of the ICHD-3 beta/proposed ICD-11 diagnostic criteria for migraine with aura. ⁶²	Li D...Olesen J	25424707	2015
26	Unique Migraine Subtypes, Rare Headache Disorders, and Other Disturbances. ⁶²	Goadsby PJ	26252589	2015
27	Greater Occipital Nerve Blockade: A Safe and Effective Option for the Acute Treatment of Hemiplegic Aura. ⁶²	Casas-Limon J...Cuadrado ML	26140423	2015
28	Paroxysmal nonepileptic events in infancy, childhood, and adolescence. ⁶²	Luat AF...Sivaswamy L	25658214	2015
29	Clinical characteristics of basilar-type migraine in the neurological clinic of a university hospital. ⁶²	Ying G...Zhou J	24666545	2014
30	Topiramate for migraine prophylaxis in pediatric patients. ⁶²	Deaton TL...Mauro LS	24566461	2014
31	[Basilar type migraine: clinical features, differential diagnosis]. ⁶²	Stulin ID...Tardova IM	24662337	2014
32	Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. ⁶²	Taghdiri F...Refaeian F	24834377	2014
33	[Cochleovestibular disorders in the patients suffering from migraine of the basilar type]. ⁶²	Kunel'skaia NL...Zaoeva ZO	25734300	2014
34	Unrecognized paraganglioma of the urinary bladder as a cause for basilar-type migraine. ⁶²	Pichler R...Steiner H	23735539	2014
35	Migraine variants--occurrence in pediatric neurology practice. ⁶²	Pacheva IH...Ivanov IS	23688445	2013
36	Lomerizine therapy for the treatment of benign paroxysmal vertigo of childhood transitioning into atypical basilar migraine: A case report. ⁶²	Inoue Y...Yabe T	23837033	2013
37	Vertebrobasilar dolichoectasia causing a presentation resembling basilar-type migraine. ⁶²	Huang L...Wang Y	22877683	2013
38	Basilar-type migraine patients responsive to lamotrigine: a 5-year follow-up. ⁶²	Cologno D...Bussone G	23695071	2013
39	Ventricular tachycardia during basilar-type migraine attack. ⁶²	Pitarokoili K...Krogias C	23277791	2013
40	[Migraine with prolonged atypical aura: report of two cases]. ⁶²	Coban A	23588869	2013
41	Transient cortical blindness as a manifestation of solitary cysticercus granuloma. ⁶²	Hussain S...Hussain S	23230251	2012
42	Dry eyes and migraines: is there really a correlation? ⁶²	Koktekir BE...Kal A	22710496	2012
43	Basic mechanisms of migraine and its acute treatment. ⁶²	Edvinsson L...MaassenVanDenBrink A	22939884	2012
44	Migraine and motion sensitivity. ⁶²	Furman JM...Marcus DA	23042062	2012
45	The enigma of the dorsolateral pons as a migraine generator. ⁶²	Borsook D...Burstein R	22798640	2012
46	Headaches in children. ⁶²	Babineau SE...Green MW	22868546	2012
47	[Migraine associated with conversion symptoms (Babinski's migraine): evaluation of a series of 43 cases]. ⁶²	Garcia-Albea E	21889233	2012
48	[Familial hemiplegic migraine type 2: two paediatric case reports]. ⁶²	Toledo-Bravo de Laguna L...Sebastian-Garcia I	22314763	2012
49	Basilar migraine mistaken for encephalitis. ⁶²	Zambito Marsala S...Gioulis M	21678071	2012
50	Primary headache disorders and neuro-ophthalmologic manifestations. ⁶²	Schwartz DP...Robbins MS	28539781	2012

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Genes for Migraine with Brainstem Aura

Genes related to Migraine with Brainstem Aura (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ATP1A2	ATPase Na+/K+ Transporting Subunit Alpha 2	Protein Coding	9.23	Novoseek inferred ⁵³	16344534

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Variations for Migraine with Brainstem Aura

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Expression for Migraine with Brainstem Aura

Search GEO for disease gene expression data for Migraine with Brainstem Aura.

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Pathways for Migraine with Brainstem Aura

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GO Terms for Migraine with Brainstem Aura

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Sources for Migraine with Brainstem Aura

¹ BitterDB

² CDC

³ Cell Signaling Technology

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⁸ Cosmic

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²¹ GeneCards

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

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⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

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⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MBA MCID: MGR035 MIFTS: 25	Migraine with Brainstem Aura (MBA) Categories: Cardiovascular diseases, Eye diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Migraine with Brainstem Aura (MBA)

Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Classifications:

External Ids:

Summaries for Migraine with Brainstem Aura

Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:

Symptoms & Phenotypes for Migraine with Brainstem Aura

Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Migraine with Brainstem Aura

Anatomical Context for Migraine with Brainstem Aura

Organs/tissues related to Migraine with Brainstem Aura:

Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

Genes for Migraine with Brainstem Aura

Genes related to Migraine with Brainstem Aura (0 elite genes):

Variations for Migraine with Brainstem Aura

Expression for Migraine with Brainstem Aura

Pathways for Migraine with Brainstem Aura

GO Terms for Migraine with Brainstem Aura

Sources for Migraine with Brainstem Aura