MBA
MCID: MGR035
MIFTS: 22

Migraine with Brainstem Aura (MBA)

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Migraine with Brainstem Aura

MalaCards integrated aliases for Migraine with Brainstem Aura:

Name: Migraine with Brainstem Aura 20
Basilar-Type Migraine 20 70
Basilar Migraine 20 54
Vertebrobasilar Migraine 20
Basilar Artery Migraine 20
Bickerstaff Migraine 20
Brainstem Migraine 20
Mba 20

Classifications:



External Ids:

UMLS 70 C0270860

Summaries for Migraine with Brainstem Aura

GARD : 20 Migraine with brainstem aura (MBA) is a type of migraine headache with aura that is associated with pain at the back of the head on both sides. An aura is a group of symptoms that generally serve as a warning sign that a bad headache is coming. Auras may consist of dizziness and vertigo, slurred speech, ataxia, tinnitus, visual changes, and/or loss of balance. Although MBA can occur in men and women of all ages, they are most common in adolescent girls. The exact underlying cause of MBA is poorly understood. Migraines are likely complex disorders that are influenced by multiple genes, in combination with lifestyle and environmental factors. In rare cases, susceptibility to MBA may be caused by a change ( mutation ) in the ATP1A2 gene or CACNA1A gene. Treatment during an episode may include nonsteroidal anti-inflammatory drugs (NSAIDs) and antiemetic medications to help ease the symptoms.

MalaCards based summary : Migraine with Brainstem Aura, also known as basilar-type migraine, is related to migraine, familial hemiplegic, 2 and migraine with or without aura 1. An important gene associated with Migraine with Brainstem Aura is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2). The drugs Topiramate and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include breast, cerebellum and bone.

Related Diseases for Migraine with Brainstem Aura

Diseases related to Migraine with Brainstem Aura via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 78, show less)
# Related Disease Score Top Affiliating Genes
1 migraine, familial hemiplegic, 2 11.2
2 migraine with or without aura 1 10.5
3 migraine with aura 10.4
4 ataxia and polyneuropathy, adult-onset 10.3
5 headache 10.3
6 osteoarthritis 10.2
7 ocular motor apraxia 10.2
8 pathologic nystagmus 10.2
9 kleine-levin hibernation syndrome 10.1
10 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
11 recurrent hypersomnia 10.1
12 hypersomnia 10.1
13 breast cancer 10.1
14 seizure disorder 10.0
15 48,xyyy 10.0
16 kearns-sayre syndrome 10.0
17 yemenite deaf-blind hypopigmentation syndrome 10.0
18 familial hemiplegic migraine 10.0
19 hydrocephalus 10.0
20 amnestic disorder 10.0
21 locked-in syndrome 10.0
22 migraine without aura 10.0
23 transient global amnesia 10.0
24 demyelinating disease 10.0
25 retrograde amnesia 10.0
26 whiplash 10.0
27 rare headache 10.0
28 episodic ataxia, type 2 10.0
29 paragangliomas 4 10.0
30 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.0
31 migraine, familial hemiplegic, 1 10.0
32 medulloblastoma 10.0
33 motion sickness 10.0
34 pheochromocytoma 10.0
35 torticollis 10.0
36 gastrointestinal stromal tumor 10.0
37 migraine, familial hemiplegic, 3 10.0
38 developmental and epileptic encephalopathy 42 10.0
39 paraganglioma 10.0
40 telangiectasis 10.0
41 neuroendocrine tumor 10.0
42 sleep disorder 10.0
43 barre-lieou syndrome 10.0
44 episodic ataxia 10.0
45 hereditary paraganglioma-pheochromocytoma syndromes 10.0
46 nonsyndromic paraganglioma 10.0
47 autonomic dysfunction 10.0
48 benign paroxysmal torticollis of infancy 10.0
49 cardiac arrhythmia 9.9
50 chiari malformation type ii 9.9
51 alternating hemiplegia of childhood 9.9
52 agraphia 9.9
53 sensorineural hearing loss 9.9
54 viral meningitis 9.9
55 hemiplegia 9.9
56 alexia 9.9
57 conversion disorder 9.9
58 lateral medullary syndrome 9.9
59 dysgraphia 9.9
60 brain edema 9.9
61 meningitis 9.9
62 encephalitis 9.9
63 atp1a3-related neurologic disorders 9.9
64 chiari malformation 9.9
65 sporadic hemiplegic migraine 9.9
66 paresthesia 9.9
67 thrombophilia due to thrombin defect 9.9
68 arts syndrome 9.9
69 aging 9.9
70 chorioamnionitis 9.9
71 bone resorption disease 9.9
72 bacterial infectious disease 9.9
73 allergic urticaria 9.9
74 clubfoot 9.9
75 porphyria 9.9
76 urticaria 9.9
77 breast ductal carcinoma 9.9
78 chronic pain 9.9

Graphical network of the top 20 diseases related to Migraine with Brainstem Aura:



Diseases related to Migraine with Brainstem Aura

Symptoms & Phenotypes for Migraine with Brainstem Aura

Drugs & Therapeutics for Migraine with Brainstem Aura

Drugs for Migraine with Brainstem Aura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 3, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2, Phase 3 97240-79-4 5284627
2 Hypoglycemic Agents Phase 2, Phase 3
3 Anticonvulsants Phase 2, Phase 3

Interventional clinical trials:

(showing 2, show less)
# Name Status NCT ID Phase Drugs
1 A Double-Blind Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00131443 Phase 2, Phase 3 Topiramate
2 An Open-Label Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00158002 Phase 2 Topiramate

Search NIH Clinical Center for Migraine with Brainstem Aura

Genetic Tests for Migraine with Brainstem Aura

Anatomical Context for Migraine with Brainstem Aura

MalaCards organs/tissues related to Migraine with Brainstem Aura:

40
Breast, Cerebellum, Bone, Brain

Publications for Migraine with Brainstem Aura

Articles related to Migraine with Brainstem Aura:

(showing 69, show less)
# Title Authors PMID Year
1
Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability. 61
32394190 2020
2
Migraine Aura: Updates in Pathophysiology and Management. 61
32430657 2020
3
How to define migraine with brainstem aura? 61
32282900 2020
4
Neuroimaging for Migraine: The American Headache Society Systematic Review and Evidence-Based Guideline. 61
31891197 2020
5
Migraine with brainstem aura: defining the core syndrome. 61
31789370 2019
6
Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second-Generation Gepants, and Cardiovascular Risk. 61
31318457 2019
7
A singular association of migraine with brainstem aura and Alice in Wonderland syndrome. 61
31049666 2019
8
Vestibular Migraine: How to Sort it Out and What to Do About it. 61
31094996 2019
9
Episodic Migraine With and Without Aura: Key Differences and Implications for Pathophysiology, Management, and Assessing Risks. 61
30291554 2018
10
Migraine with brainstem aura: Why not a cortical origin? 61
29073774 2018
11
Basilar-type migraine: An overlooked cause of loss of consciousness in pediatric emergency rooms. 61
28890047 2018
12
Exploding Head Syndrome as Aura of Migraine with Brainstem Aura: A Case Report. 61
29694468 2018
13
Paranasal Sinus Disease in Children With Headache. 61
28831857 2017
14
Possible Involvement of the CACNA1E Gene in Migraine: A Search for Single Nucleotide Polymorphism in Different Clinical Phenotypes. 61
28573794 2017
15
Migraine with Aura or Sports-Related Concussion: Case Report, Pathophysiology, and Multidisciplinary Approach to Management. 61
28067735 2017
16
Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). 61
27343267 2016
17
Complicated Migraines. 61
27017017 2016
18
A Valuable Case for Recognizing the Relationship between Arrhythmia and the Biology of Migraine with Brainstem Aura. 61
27404408 2016
19
Field-testing of the ICHD-3 beta/proposed ICD-11 diagnostic criteria for migraine with aura. 61
25424707 2015
20
Unique Migraine Subtypes, Rare Headache Disorders, and Other Disturbances. 61
26252589 2015
21
Greater Occipital Nerve Blockade: A Safe and Effective Option for the Acute Treatment of Hemiplegic Aura. 61
26140423 2015
22
Clinical characteristics of basilar-type migraine in the neurological clinic of a university hospital. 61
24666545 2014
23
[Basilar type migraine: clinical features, differential diagnosis]. 61
24662337 2014
24
Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. 61
24834377 2014
25
[Cochleovestibular disorders in the patients suffering from migraine of the basilar type]. 61
25734300 2014
26
Unrecognized paraganglioma of the urinary bladder as a cause for basilar-type migraine. 61
23735539 2014
27
Migraine variants--occurrence in pediatric neurology practice. 61
23688445 2013
28
Vertebrobasilar dolichoectasia causing a presentation resembling basilar-type migraine. 61
22877683 2013
29
Basilar-type migraine patients responsive to lamotrigine: a 5-year follow-up. 61
23695071 2013
30
[Migraine with prolonged atypical aura: report of two cases]. 61
23588869 2013
31
Ventricular tachycardia during basilar-type migraine attack. 61
23277791 2013
32
[Migraine associated with conversion symptoms (Babinski's migraine): evaluation of a series of 43 cases]. 61
21889233 2012
33
A curiosity in the history of sciences: the words "megrim" and "migraine". 61
22239094 2012
34
Primary headache disorders and neuro-ophthalmologic manifestations. 61
28539781 2012
35
Migraine with binocular blindness: a clinic-based study. 61
21812773 2011
36
Basilar-type migraine with coma: case reports and literature review. 61
21463463 2011
37
Vertebral artery dissection presented as lateral medullary syndrome in a patient with migraine: a case report. 61
21210329 2010
38
Dihydroergotamine and its use in migraine with posterior fossa symptoms. 61
20533960 2010
39
Migraine with aura with onset in childhood and adolescence: long-term natural history and prognostic factors. 61
20511205 2010
40
Acute treatment of basilar-type migraine with greater occipital nerve blockade. 61
20487035 2010
41
Migraine-associated psychosis and subsequent renal transplant. 61
20118445 2010
42
Vestibular migraine. 61
20816468 2010
43
Pontine capillary telangiectasia as visualized on MR imaging causing a clinical picture resembling basilar-type migraine: a case report. 61
19533201 2009
44
[Vestibular migraine]. 61
19629427 2009
45
CACNA1A nonsense mutation is associated with basilar-type migraine and episodic ataxia type 2. 61
19486177 2009
46
Basilar-type migraine. 61
19457282 2009
47
Vertigo as a symptom of migraine. 61
19645907 2009
48
Pediatric migraine. 61
19289227 2009
49
Infant brain stem is prone to the generation of spreading depression during severe hypoxia. 61
19261708 2009
50
Relationship between basilar-type migraine and migrainous vertigo. 61
19178580 2009
51
"Vestibular migraine": effects of prophylactic therapy with various drugs. A retrospective study. 61
19266150 2009
52
[Migrainous aura subtypes in hospitalized children]. 61
20297637 2009
53
Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. 61
18644040 2008
54
ATP1A2 gene mutations are not present in two sisters with basilar-type migraine associated with menses. 61
18483709 2008
55
Lifetime basilar migraine: a pontine syndrome? 61
18081824 2008
56
Investigation of neuromuscular transmission in some rare types of migraine. 61
17919307 2007
57
A double-blind, dose comparison study of topiramate for prophylaxis of basilar-type migraine in children: a pilot study. 61
18052950 2007
58
The cerebellum and migraine. 61
17578530 2007
59
Basilar-type migraine responsive to lamotrigine: three case reports. 61
17508181 2007
60
Basilar artery fenestration in a woman with basilar-type migraine. 61
17464479 2007
61
Caloric and vestibular evoked myogenic potential tests in evaluating children with benign paroxysmal vertigo. 61
17196672 2007
62
Medulloblastoma induces unusual headache with clinical picture of basilar-type migraine complicated by ischaemic infarcts. 61
16961793 2006
63
Basilar-type migraine: clinical, epidemiologic, and genetic features. 61
16567706 2006
64
Familial basilar migraine associated with a new mutation in the ATP1A2 gene. 54
16344534 2005
65
[Basilar-type migraine: pathophysiology, symptoms and signs, and treatment]. 61
16419573 2005
66
Preventing disturbing migraine aura with lamotrigine: an open study. 61
15546267 2004
67
New international classification of migraine with aura (ICHD-2) applied to 362 migraine patients. 61
15379737 2004
68
Vestibular migraine. 61
15228892 2004
69
A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. 61
12023326 2002

Variations for Migraine with Brainstem Aura

Expression for Migraine with Brainstem Aura

Search GEO for disease gene expression data for Migraine with Brainstem Aura.

Pathways for Migraine with Brainstem Aura

GO Terms for Migraine with Brainstem Aura

Sources for Migraine with Brainstem Aura

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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