MCID: MGR028
MIFTS: 49

Migraine with or Without Aura 1

Categories: Neuronal diseases

Aliases & Classifications for Migraine with or Without Aura 1

MalaCards integrated aliases for Migraine with or Without Aura 1:

Name: Migraine with or Without Aura 1 57
Migraine 57 12 76 54 29 55 6 43 15 63 40
Migraine with or Without Aura, Susceptibility to, 1 57 13
Migraine Disorders 44 73
Migraine Variant 12 73
Migraine Without Aura, Susceptibility to 6
Migraine with or Without Aura 12
Migraine, Susceptibility to 6
Migraine Disorder 12
Mgau; Ma 57
Mgr1 57
Mgau 57
Ma 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
headache duration 4-72 hours
aggravated by physical activity
genetic heterogeneity, see, e.g., mgr2 , mgr3 , mgr4 , mgr5 , mgr6


HPO:

32
migraine with or without aura 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Migraine with or Without Aura 1

MedlinePlus : 43 What are migraines? Migraines are a recurring type of headache. They cause moderate to severe pain that is throbbing or pulsing. The pain is often on one side of your head. You may also have other symptoms, such as nausea and weakness. You may be sensitive to light and sound. Who gets migraines? About 12 percent of Americans get migraines. They can affect anyone, but you are more likely to have them if you Are a woman. Women are three times more likely than men to get migraines. Have a family history of migraines. Most people with migraines have family members who have migraines. Have other medical conditions, such as depression, anxiety, bipolar disorder, sleep disorders, and epilepsy. What causes migraines? Researchers believe that migraine has a genetic cause. There are also a number of factors that can trigger a migraine, including Stress Anxiety Hormonal changes in women Bright or flashing lights Loud noises Strong smells Medicines Too much or not enough sleep Sudden changes in weather or environment Overexertion (too much physical activity) Tobacco Caffeine or caffeine withdrawal Skipped meals Medication overuse (taking medicine for migraines too often) Certain foods and food additives such as Alcohol Chocolate Aged cheeses Monosodium glutamate (MSG) Some fruits and nuts Fermented or pickled goods Yeast Cured or processed meats What are the symptoms of migraines? There are four different phases of migraines. You may not always go through every phase each time you have a migraine. Prodome. This phase starts up to 24 hours before you get the migraine. You have early signs and symptoms, such as food cravings, unexplained mood changes, uncontrollable yawning, fluid retention, and increased urination. Aura. If you have this phase, you might see flashing or bright lights or zig-zag lines. You may have muscle weakness or feel like you are being touched or grabbed. An aura can happen just before or during a migraine. Headache. A migraine usually starts gradually and then becomes more severe. It typically causes throbbing or pulsing pain, which is often on one side of your head. But sometimes you can have a migraine without a headache. Other migraine symptoms may include Increased sensitivity to light, noise, and odors Nausea and vomiting Worsened pain when you move, cough, or sneeze Postdrome (following the headache). You may feel exhausted, weak, and confused after a migraine. This can last up to a day. Migraines are more common in the morning; people often wake up with them. Some people have migraines at predictable times, such as before menstruation or on weekends following a stressful week of work. How are migraines diagnosed? To make a diagnosis, your health care provider will Take your medical history Ask about your symptoms Do a physical and neurological exam An important part of diagnosing migraines is to rule out other medical conditions which could be causing the symptoms. So you may also have blood tests, an MRI or CT scan, or other tests. How are migraines treated? There is no cure for migraines. Treatment focuses on relieving symptoms and preventing additional attacks. There are different types of medicines to relieve symptoms. They include triptan drugs, ergotamine drugs, and pain relievers. The sooner you take the medicine, the more effective it is. There are also other things you can do to feel better: Resting with your eyes closed in a quiet, darkened room Placing a cool cloth or ice pack on your forehead Drinking fluids There are some lifestyle changes you can make to prevent migraines: Stress management strategies, such as exercise, relaxation techniques, and biofeedback, may reduce the number and severity of migraines. Biofeedback uses electronic devices to teach you to control certain body functions, such as your heartbeat, blood pressure, and muscle tension. Make a log of what seems to trigger your migraines. You can learn what you need to avoid, such as certain foods and medicines. It also help you figure out what you should do, such as establishing a consistent sleep schedule and eating regular meals. Hormone therapy may help some women whose migraines seem to be linked to their menstrual cycle If you have obesity, losing weight may also be helpful If you have frequent or severe migraines, you may need to take medicines to prevent further attacks. Talk with your health care provider about which drug would be right for you. Certain natural treatments, such as riboflavin (vitamin B2) and coenzyme Q10, may help prevent migraines. If your magnesium level is low, you can try taking magnesium. There is also an herb, butterbur, which some people take to prevent migraines. But butterbur may not be safe for long-term use. Always check with your health care provider before taking any supplements. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine with aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is PPOX (Protoporphyrinogen Oxidase), and among its related pathways/superpathways are Ion channel transport and Taste transduction. Affiliated tissues include testes, brain and eye, and related phenotypes are photophobia and vomiting

OMIM : 57 Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; 607498), 14q21.2-q22.3 (MGR4; 607501), 19p13 (MGR5; 607508), 1q31 (MGR6; 607516), 15q11-q13 (MGR7; 609179), 5q21 (with or without aura, MGR8, 609570; with aura, MGR9, 609670), 17p13 (MGR10; 610208), 18q12 (MGR11; 610209), 10q22-q23 (MGR12; 611706), and the X chromosome (MGR2; 300125). Mutation in the KCNK18 gene (613655) on chromosome 10q25 causes migraine with aura (MGR13; 613656). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see 141500), is caused by mutation in the CACNA1A gene (601011) on chromosome 19p13 (FHM1; 141500), by mutation in the ATP1A2 gene (182340) on chromosome 1q21 (FHM2; 602481), or by mutation in the SCN1A gene (182389) on chromosome 2q24 (FHM3; 609634). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see 607516). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; 133430.0005) and a polymorphism in the TNF gene (191160.0004) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; 131243.0001) may confer resistance to migraine. (157300)

NINDS : 54 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.  Migraine in some women may relate to changes in hormones and hormonal levels during their menstrual cycle.  For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine has a genetic cause.

Disease Ontology : 12 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

PubMed Health : 63 About migraine: Migraine is not the same as the usual kind of headaches that most people have every now and then. A migraine attack starts suddenly with severe pain on only one side of your head. The pain is much worse than a normal headache and usually accompanied by other symptoms as well.But these headaches are only considered to be migraines if the typical symptoms have occurred at least five times.Migraines can greatly affect everyday life. Some people only get them occasionally, while others are knocked out by migraines on several days every month. Different types of medicine can help you cope with migraines.

Wikipedia : 76 A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to... more...

Related Diseases for Migraine with or Without Aura 1

Diseases related to Migraine with or Without Aura 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 familial hemiplegic migraine 35.3 ATP1A2 CACNA1A CALCA NOTCH3 SCN1A TRPV1
2 migraine with aura 33.1 ATP1A2 CACNA1A EDNRA HTR1B MGR1 NOTCH3
3 migraine without aura 31.4 ATP1A2 CACNA1A SCN1A
4 headache 31.0 ATP1A2 CACNA1A EDNRA SCN1A TNF
5 constipation 30.9 CALCA HTR3A PPOX
6 migraine with or without aura 13 12.7
7 migraine, familial hemiplegic, 2 12.4
8 migraine with or without aura 12 12.4
9 migraine with or without aura 3 12.4
10 mccune-albright syndrome 12.0
11 meconium aspiration syndrome 11.8
12 migraine without aura 4 11.4
13 macrophage activation syndrome 11.3
14 vitamin b12-responsive methylmalonic acidemia 11.2
15 familial or sporadic hemiplegic migraine 11.2 ATP1A2 CACNA1A SCN1A
16 sporadic hemiplegic migraine 11.1 ATP1A2 CACNA1A SCN1A
17 migraine with or without aura 8 11.1
18 female reproductive system disease 11.1 ESR1 TNF TRPV1
19 asthma 11.1
20 bone resorption disease 11.1 CALCA ESR1 TRPV1
21 bone remodeling disease 11.1 CALCA ESR1 TRPV1
22 reproductive system disease 11.1 ESR1 TNF TRPV1
23 nervous system disease 11.1 CACNA1A SCN1A TNF TRPV1
24 bullous impetigo 11.1 CALCA EDNRA
25 irritable bowel syndrome 11.1 HTR3A TNF TRPV1
26 alternating hemiplegia of childhood 11.1 ATP1A2 CACNA1A CALCA
27 endomyocardial fibrosis 11.1 CLCN1 TNF
28 hemiplegia 11.1 ATP1A2 CACNA1A CALCA SCN1A
29 autoinflammation with infantile enterocolitis 11.0
30 central nervous system disease 11.0 CACNA1A NOTCH3 SCN1A TNF TRPV1
31 vulvar vestibulitis syndrome 11.0 ESR1 TNF
32 breast adenocarcinoma 11.0 CALCA ESR1 TNF
33 migraine with or without aura 5 10.9
34 hemiplegic migraine 10.9 ATP1A2 CACNA1A CALCA MGR5 MGR6 NOTCH3
35 lymphangioleiomyomatosis 10.9
36 fibrous dysplasia/mccune-albright syndrome 10.9
37 diarrhea 10.9 CACNA1A HTR3A TNF
38 cluster headache 10.9 CACNA1A CALCA
39 erysipelas 10.8 CALCA TNF
40 carney complex, type 1 10.8
41 sarcoidosis 1 10.8
42 acth-independent macronodular adrenal hyperplasia 10.8
43 gaucher disease, type iii 10.8
44 hemochromatosis, type 1 10.8
45 alpha-1-antitrypsin deficiency 10.8
46 pulmonary hypertension, primary, 4 10.8
47 immunodeficiency 11b with atopic dermatitis 10.8
48 acrodermatitis 10.8
49 metanephric adenoma 10.8
50 radiation proctitis 10.7 EDNRA TNF

Comorbidity relations with Migraine with or Without Aura 1 via Phenotypic Disease Network (PDN):


Anxiety Esophagitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Migraine with or Without Aura 1:



Diseases related to Migraine with or Without Aura 1

Symptoms & Phenotypes for Migraine with or Without Aura 1

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
photophobia
phonophobia
migraine with aura
migraine without aura
headache is unilateral
more
Abdomen Gastrointestinal:
vomiting
nausea


Clinical features from OMIM:

157300

Human phenotypes related to Migraine with or Without Aura 1:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 photophobia 32 HP:0000613
2 vomiting 32 HP:0002013
3 phonophobia 32 HP:0002183
4 nausea 32 HP:0002018
5 migraine with aura 32 HP:0002077
6 migraine without aura 32 HP:0002083

UMLS symptoms related to Migraine with or Without Aura 1:


back pain, headache, hemiplegia, nausea, pain, sciatica, seizures, syncope, tremor, chronic pain, scotoma, scintillating, vertigo/dizziness, hemicrania, sleeplessness, recurrent paroxysmal headache

MGI Mouse Phenotypes related to Migraine with or Without Aura 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 ATP1A2 CACNA1A CLCN1 EDNRA ESR1 HTR1B
2 integument MP:0010771 9.97 HTR3A NOTCH3 TNF TRPV1 ATP1A2 CACNA1A
3 muscle MP:0005369 9.91 ATP1A2 CACNA1A CLCN1 EDNRA ESR1 HTR1B
4 nervous system MP:0003631 9.85 SCN1A TNF TRPV1 ATP1A2 CACNA1A CLCN1
5 reproductive system MP:0005389 9.56 CACNA1A CLCN1 ESR1 HTR1B HTR3A NOTCH3
6 respiratory system MP:0005388 9.17 ATP1A2 CACNA1A EDNRA ESR1 NOTCH3 SCN1A

Drugs & Therapeutics for Migraine with or Without Aura 1

PubMedHealth treatment related to Migraine with or Without Aura 1: 63

A lot of people who have migraines know from experience what helps them. This often involves lying down in a quiet and dark room and putting cool wet towels or cooling pads on the side of their head that hurts.Most people take medicine to get through attacks that are especially painful. Medications used for migraine attacks include, in particular, acetaminophen (paracetamol), non-steroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (the drug in medicines like Aspirin), diclofenac or ibuprofen, as well as special migraine medications like triptans. Acetaminophen (paracetamol), acetylsalicylic acid and ibuprofen are available without a prescription, as are two of the triptan drugs. But before using medication yourself it’s a good idea to see a doctor to find out if the headaches are actually migraines.Using painkillers and migraine medication too often can itself make the headaches worse. For this reason, people are advised not to take painkillers and migraine medications on more than ten days per month.

Search Clinical Trials , NIH Clinical Center for Migraine with or Without Aura 1

Cochrane evidence based reviews: migraine disorders

Genetic Tests for Migraine with or Without Aura 1

Genetic tests related to Migraine with or Without Aura 1:

# Genetic test Affiliating Genes
1 Migraine 29 EDNRA ESR1 TNF

Anatomical Context for Migraine with or Without Aura 1

MalaCards organs/tissues related to Migraine with or Without Aura 1:

41
Testes, Brain, Eye

Publications for Migraine with or Without Aura 1

Articles related to Migraine with or Without Aura 1:

# Title Authors Year
1
Contribution of intra-vestibular sensory conflict to motion sickness and dizziness in migraine disorders. ( 27385797 )
2016
2
Randomized clinical trial of intravenous valproate (orifil) and dexamethasone in patients with migraine disorder. ( 24031104 )
2013
3
Genetics of migraine without aura, migraine with aura, migrainous disorder, head trauma migraine without aura and tension-type headache. ( 11595012 )
2001
4
Migraine without aura and migrainous disorder in children; International Headache Society (IHS) and revised IHS criteria. ( 11128818 )
2000
5
Migrainous disorder and its relation to migraine without aura and migraine with aura. A genetic epidemiological study. ( 8902253 )
1996

Variations for Migraine with or Without Aura 1

ClinVar genetic disease variations for Migraine with or Without Aura 1:

6
(show all 20)
# Gene Variation Type Significance SNP ID Assembly Location
1 TNF TNF, -308G-A single nucleotide variant risk factor
2 ESR1 ESR1, 594G-A single nucleotide variant risk factor
3 CLCN1 NM_000083.2(CLCN1): c.950G> A (p.Arg317Gln) single nucleotide variant Pathogenic/Likely pathogenic rs80356702 GRCh37 Chromosome 7, 143027961: 143027961
4 CLCN1 NM_000083.2(CLCN1): c.950G> A (p.Arg317Gln) single nucleotide variant Pathogenic/Likely pathogenic rs80356702 GRCh38 Chromosome 7, 143330868: 143330868
5 CAPN3; SGCB NM_000070.2(CAPN3): c.550delA (p.Thr184Argfs) deletion Pathogenic rs80338800 GRCh37 Chromosome 15, 42680002: 42680002
6 CAPN3; SGCB NM_000070.2(CAPN3): c.550delA (p.Thr184Argfs) deletion Pathogenic rs80338800 GRCh38 Chromosome 15, 42387804: 42387804
7 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh37 Chromosome 14, 23856794: 23856794
8 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh38 Chromosome 14, 23387585: 23387585
9 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh37 Chromosome 6, 149700090: 149700090
10 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh38 Chromosome 6, 149378954: 149378954
11 SLC2A1 NM_006516.2(SLC2A1): c.1407G> C (p.Gln469His) single nucleotide variant Uncertain significance rs201748668 GRCh37 Chromosome 1, 43392784: 43392784
12 SLC2A1 NM_006516.2(SLC2A1): c.1407G> C (p.Gln469His) single nucleotide variant Uncertain significance rs201748668 GRCh38 Chromosome 1, 42927113: 42927113
13 PPOX NM_000309.4(PPOX): c.1353T> G (p.Tyr451Ter) single nucleotide variant Pathogenic rs148292941 GRCh37 Chromosome 1, 161140885: 161140885
14 PPOX NM_000309.4(PPOX): c.1353T> G (p.Tyr451Ter) single nucleotide variant Pathogenic rs148292941 GRCh38 Chromosome 1, 161171095: 161171095
15 STIM1 NM_001277961.1(STIM1): c.1534T> A (p.Ser512Thr) single nucleotide variant Uncertain significance GRCh38 Chromosome 11, 4086536: 4086536
16 STIM1 NM_001277961.1(STIM1): c.1534T> A (p.Ser512Thr) single nucleotide variant Uncertain significance GRCh37 Chromosome 11, 4107766: 4107766
17 NOTCH3 NM_000435.2(NOTCH3): c.1450T> G (p.Cys484Gly) single nucleotide variant Likely pathogenic GRCh37 Chromosome 19, 15299088: 15299088
18 NOTCH3 NM_000435.2(NOTCH3): c.1450T> G (p.Cys484Gly) single nucleotide variant Likely pathogenic GRCh38 Chromosome 19, 15188277: 15188277
19 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 4102388: 4102388
20 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 4102390: 4102390

Copy number variations for Migraine with or Without Aura 1 from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39736 10 118956999 118969809 Copy number KCNK18 Migraine

Expression for Migraine with or Without Aura 1

Search GEO for disease gene expression data for Migraine with or Without Aura 1.

Pathways for Migraine with or Without Aura 1

Pathways related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 ATP1A2 CLCN1 HTR3A TRPV1
2
Show member pathways
11.52 CACNA1A HTR1B HTR3A
3 11.4 ATP1A2 ESR1 NOTCH3
4 10.85 CACNA1A HTR1B HTR3A

GO Terms for Migraine with or Without Aura 1

Cellular components related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.02 CACNA1A CALCA HTR3A SCN1A TRPV1

Biological processes related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.8 ATP1A2 CACNA1A CLCN1 HTR3A SCN1A TRPV1
2 regulation of membrane potential GO:0042391 9.7 CACNA1A HTR3A SCN1A
3 regulation of blood pressure GO:0008217 9.58 ATP1A2 CALCA EDNRA
4 vasoconstriction GO:0042310 9.51 EDNRA HTR1B
5 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.49 CALCA TRPV1
6 G-protein coupled receptor internalization GO:0002031 9.48 CALCA HTR1B
7 behavioral response to pain GO:0048266 9.46 CACNA1A TRPV1
8 cellular response to alkaloid GO:0071312 9.43 HTR1B TRPV1
9 ion transmembrane transport GO:0034220 9.43 ATP1A2 CACNA1A CLCN1 HTR3A SCN1A TRPV1
10 neuronal action potential propagation GO:0019227 9.37 CLCN1 SCN1A
11 response to pain GO:0048265 9.33 CACNA1A CALCA TRPV1
12 cellular response to temperature stimulus GO:0071502 9.26 HTR1B TRPV1
13 positive regulation of cytosolic calcium ion concentration GO:0007204 9.02 CACNA1A CALCA EDNRA ESR1 TRPV1

Molecular functions related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 9.16 HTR1B HTR3A
2 cation channel activity GO:0005261 9.13 CACNA1A SCN1A TRPV1
3 ion channel activity GO:0005216 8.92 CACNA1A HTR3A SCN1A TRPV1

Sources for Migraine with or Without Aura 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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