MA
MCID: MGR028
MIFTS: 69

Migraine with or Without Aura 1 (MA)

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Migraine with or Without Aura 1

MalaCards integrated aliases for Migraine with or Without Aura 1:

Name: Migraine with or Without Aura 1 57
Migraine 57 12 76 54 29 55 6 43 15 63 40
Migraine with or Without Aura, Susceptibility to, 1 57 13
Migraine Disorders 44 73
Migraine Variant 12 73
Migraine Without Aura, Susceptibility to 6
Migraine with or Without Aura 12
Migraine, Susceptibility to 6
Migraine Disorder 12
Mgau; Ma 57
Mgr1 57
Mgau 57
Ma 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
headache duration 4-72 hours
aggravated by physical activity
genetic heterogeneity, see, e.g., mgr2 , mgr3 , mgr4 , mgr5 , mgr6


HPO:

32
migraine with or without aura 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Migraine with or Without Aura 1

MedlinePlus : 43 What are migraines? Migraines are a recurring type of headache. They cause moderate to severe pain that is throbbing or pulsing. The pain is often on one side of your head. You may also have other symptoms, such as nausea and weakness. You may be sensitive to light and sound. Who gets migraines? About 12 percent of Americans get migraines. They can affect anyone, but you are more likely to have them if you Are a woman. Women are three times more likely than men to get migraines. Have a family history of migraines. Most people with migraines have family members who have migraines. Have other medical conditions, such as depression, anxiety, bipolar disorder, sleep disorders, and epilepsy. What causes migraines? Researchers believe that migraine has a genetic cause. There are also a number of factors that can trigger a migraine, including Stress Anxiety Hormonal changes in women Bright or flashing lights Loud noises Strong smells Medicines Too much or not enough sleep Sudden changes in weather or environment Overexertion (too much physical activity) Tobacco Caffeine or caffeine withdrawal Skipped meals Medication overuse (taking medicine for migraines too often) Certain foods and food additives such as Alcohol Chocolate Aged cheeses Monosodium glutamate (MSG) Some fruits and nuts Fermented or pickled goods Yeast Cured or processed meats What are the symptoms of migraines? There are four different phases of migraines. You may not always go through every phase each time you have a migraine. Prodome. This phase starts up to 24 hours before you get the migraine. You have early signs and symptoms, such as food cravings, unexplained mood changes, uncontrollable yawning, fluid retention, and increased urination. Aura. If you have this phase, you might see flashing or bright lights or zig-zag lines. You may have muscle weakness or feel like you are being touched or grabbed. An aura can happen just before or during a migraine. Headache. A migraine usually starts gradually and then becomes more severe. It typically causes throbbing or pulsing pain, which is often on one side of your head. But sometimes you can have a migraine without a headache. Other migraine symptoms may include Increased sensitivity to light, noise, and odors Nausea and vomiting Worsened pain when you move, cough, or sneeze Postdrome (following the headache). You may feel exhausted, weak, and confused after a migraine. This can last up to a day. Migraines are more common in the morning; people often wake up with them. Some people have migraines at predictable times, such as before menstruation or on weekends following a stressful week of work. How are migraines diagnosed? To make a diagnosis, your health care provider will Take your medical history Ask about your symptoms Do a physical and neurological exam An important part of diagnosing migraines is to rule out other medical conditions which could be causing the symptoms. So you may also have blood tests, an MRI or CT scan, or other tests. How are migraines treated? There is no cure for migraines. Treatment focuses on relieving symptoms and preventing additional attacks. There are different types of medicines to relieve symptoms. They include triptan drugs, ergotamine drugs, and pain relievers. The sooner you take the medicine, the more effective it is. There are also other things you can do to feel better: Resting with your eyes closed in a quiet, darkened room Placing a cool cloth or ice pack on your forehead Drinking fluids There are some lifestyle changes you can make to prevent migraines: Stress management strategies, such as exercise, relaxation techniques, and biofeedback, may reduce the number and severity of migraines. Biofeedback uses electronic devices to teach you to control certain body functions, such as your heartbeat, blood pressure, and muscle tension. Make a log of what seems to trigger your migraines. You can learn what you need to avoid, such as certain foods and medicines. It also help you figure out what you should do, such as establishing a consistent sleep schedule and eating regular meals. Hormone therapy may help some women whose migraines seem to be linked to their menstrual cycle If you have obesity, losing weight may also be helpful If you have frequent or severe migraines, you may need to take medicines to prevent further attacks. Talk with your health care provider about which drug would be right for you. Certain natural treatments, such as riboflavin (vitamin B2) and coenzyme Q10, may help prevent migraines. If your magnesium level is low, you can try taking magnesium. There is also an herb, butterbur, which some people take to prevent migraines. But butterbur may not be safe for long-term use. Always check with your health care provider before taking any supplements. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including seizures, tremor and back pain. An important gene associated with Migraine with or Without Aura 1 is CLCN1 (Chloride Voltage-Gated Channel 1), and among its related pathways/superpathways are Taste transduction and Ion channel transport. Affiliated tissues include brain, testes and eye, and related phenotypes are photophobia and vomiting

Disease Ontology : 12 A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

OMIM : 57 Migraine is the most common type of chronic, episodic headache, as summarized by Featherstone (1985). One locus for migraine with or without aura (MGR1) has been identified on chromosome 4q24. Other loci for migraine have been identified on 6p21.1-p12.2 (MGR3; 607498), 14q21.2-q22.3 (MGR4; 607501), 19p13 (MGR5; 607508), 1q31 (MGR6; 607516), 15q11-q13 (MGR7; 609179), 5q21 (with or without aura, MGR8, 609570; with aura, MGR9, 609670), 17p13 (MGR10; 610208), 18q12 (MGR11; 610209), 10q22-q23 (MGR12; 611706), and the X chromosome (MGR2; 300125). Mutation in the KCNK18 gene (613655) on chromosome 10q25 causes migraine with aura (MGR13; 613656). A subtype of autosomal dominant migraine with aura (MA), familial hemiplegic migraine (FHM; see 141500), is caused by mutation in the CACNA1A gene (601011) on chromosome 19p13 (FHM1; 141500), by mutation in the ATP1A2 gene (182340) on chromosome 1q21 (FHM2; 602481), or by mutation in the SCN1A gene (182389) on chromosome 2q24 (FHM3; 609634). Another locus for FHM has been mapped to chromosome 1q31 (FHM4; see 607516). There is evidence that a polymorphism in the estrogen receptor gene (ESR1; 133430.0005) and a polymorphism in the TNF gene (191160.0004) may confer susceptibility to migraine. A polymorphism in the endothelin receptor type A gene (EDNRA; 131243.0001) may confer resistance to migraine. (157300)

NINDS : 54 The pain of a migraine headache is often described as an intense pulsing or throbbing pain in one area of the head. However, it is much more; the International Headache Society diagnoses a migraine by its pain and number of attacks (at least 5, lasting 4-72 hours if untreated), and additional symptoms including nausea and/or vomiting, or sensitivity to both light and sound. Migraine is three times more common in women than in men and affects more than 10 percent of people worldwide. Roughly one-third of affected individuals can predict the onset of a migraine because it is preceded by an "aura," visual disturbances that appear as flashing lights, zig-zag lines or a temporary loss of vision. People with migraine tend to have recurring attacks triggered by a number of different factors, including stress, anxiety, hormonal changes, bright or flashing lights, lack of food or sleep, and dietary substances.  Migraine in some women may relate to changes in hormones and hormonal levels during their menstrual cycle.  For many years, scientists believed that migraines were linked to the dilation and constriction of blood vessels in the head. Investigators now believe that migraine has a genetic cause.

PubMed Health : 63 About migraine: Migraine is not the same as the usual kind of headaches that most people have every now and then. A migraine attack starts suddenly with severe pain on only one side of your head. The pain is much worse than a normal headache and usually accompanied by other symptoms as well.But these headaches are only considered to be migraines if the typical symptoms have occurred at least five times.Migraines can greatly affect everyday life. Some people only get them occasionally, while others are knocked out by migraines on several days every month. Different types of medicine can help you cope with migraines.

Wikipedia : 76 A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to... more...

Related Diseases for Migraine with or Without Aura 1

Diseases in the Migraine Without Aura family:

Migraine with or Without Aura 1 Migraine with or Without Aura 2
Migraine with or Without Aura 3 Migraine Without Aura 4
Migraine with or Without Aura 5 Migraine with or Without Aura 6
Migraine with or Without Aura 8 Migraine with or Without Aura 10
Migraine with or Without Aura 11 Migraine with or Without Aura 12
Migraine with or Without Aura 13

Diseases related to Migraine with or Without Aura 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 636)
# Related Disease Score Top Affiliating Genes
1 familial hemiplegic migraine 34.6 TRPV1 SCN1A NOTCH3 CALCA CACNA1A ATP1A2
2 migraine without aura 34.4 SCN1A CACNA1A ATP1A2
3 sporadic hemiplegic migraine 34.3 SCN1A CACNA1A ATP1A2
4 hemiplegic migraine 34.2 SCN1A NOTCH3 MGR6 MGR5 CALCA CACNA1A
5 familial or sporadic hemiplegic migraine 33.8 SCN1A CACNA1A ATP1A2
6 cluster headache 32.4 CALCA CACNA1A
7 migraine with aura 32.3 SCN1A NOTCH3 MGR1 HTR1B EDNRA CACNA1A
8 hemiplegia 30.6 SCN1A CALCA CACNA1A ATP1A2
9 irritable bowel syndrome 30.6 TRPV1 TNF HTR3A
10 alternating hemiplegia of childhood 30.4 CALCA CACNA1A ATP1A2
11 headache 30.0 SCN1A EDNRA CACNA1A ATP1A2
12 diarrhea 30.0 TRPV1 HTR3A CACNA1A
13 constipation 29.9 PPOX HTR3A CALCA
14 nervous system disease 29.9 TRPV1 TNF SCN1A CACNA1A
15 migraine, familial hemiplegic, 2 12.6
16 migraine, familial hemiplegic, 1 12.6
17 migraine, familial hemiplegic, 3 12.6
18 migraine with brainstem aura 12.5
19 migraine with or without aura 13 12.4
20 mccune-albright syndrome 12.1
21 migraine with or without aura 2 12.1
22 migraine with or without aura 8 12.1
23 migraine with or without aura 12 12.1
24 migraine with aura 7 12.0
25 migraine with or without aura 3 12.0
26 migraine without aura 4 12.0
27 migraine with or without aura 6 12.0
28 migraine with aura 9 12.0
29 migraine with or without aura 10 12.0
30 migraine with or without aura 11 12.0
31 cyclic vomiting syndrome 11.9
32 meconium aspiration syndrome 11.9
33 epilepsy, familial temporal lobe, 4 11.7
34 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 11.5
35 handl syndrome 11.5
36 macrophage activation syndrome 11.5
37 trochleitis 11.4
38 episodic ataxia 11.4
39 hemicrania continua 11.4
40 visual snow syndrome 11.4
41 carotidynia 11.3
42 vitamin b12-responsive methylmalonic acidemia 11.3
43 asthma 11.3
44 sturge-weber syndrome 11.2
45 episodic ataxia, type 2 11.2
46 orthostatic intolerance 11.2
47 paroxysmal hemicrania 11.2
48 abducens nerve disease 11.2
49 new daily-persistent headache 11.2
50 centralopathic epilepsy 11.2

Comorbidity relations with Migraine with or Without Aura 1 via Phenotypic Disease Network (PDN):


Anxiety Esophagitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Migraine with or Without Aura 1:



Diseases related to Migraine with or Without Aura 1

Symptoms & Phenotypes for Migraine with or Without Aura 1

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
photophobia
phonophobia
migraine with aura
migraine without aura
headache is unilateral
more
Abdomen Gastrointestinal:
vomiting
nausea


Clinical features from OMIM:

157300

Human phenotypes related to Migraine with or Without Aura 1:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 photophobia 32 HP:0000613
2 vomiting 32 HP:0002013
3 phonophobia 32 HP:0002183
4 nausea 32 HP:0002018
5 migraine with aura 32 HP:0002077
6 migraine without aura 32 HP:0002083

UMLS symptoms related to Migraine with or Without Aura 1:


seizures, tremor, back pain, pain, headache, hemiplegia, syncope, nausea, recurrent paroxysmal headache, chronic pain, sciatica, vertigo/dizziness, sleeplessness, scotoma, scintillating, hemicrania

MGI Mouse Phenotypes related to Migraine with or Without Aura 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 ATP1A2 CACNA1A CLCN1 EDNRA ESR1 HTR1B
2 integument MP:0010771 9.97 ATP1A2 CACNA1A CLCN1 EDNRA ESR1 HTR3A
3 muscle MP:0005369 9.91 ATP1A2 CACNA1A CLCN1 EDNRA ESR1 HTR1B
4 nervous system MP:0003631 9.85 ATP1A2 CACNA1A CLCN1 EDNRA ESR1 HTR3A
5 reproductive system MP:0005389 9.56 CACNA1A CLCN1 ESR1 HTR1B HTR3A NOTCH3
6 respiratory system MP:0005388 9.17 ATP1A2 CACNA1A EDNRA ESR1 NOTCH3 SCN1A

Drugs & Therapeutics for Migraine with or Without Aura 1

PubMedHealth treatment related to Migraine with or Without Aura 1: 63

A lot of people who have migraines know from experience what helps them. This often involves lying down in a quiet and dark room and putting cool wet towels or cooling pads on the side of their head that hurts.Most people take medicine to get through attacks that are especially painful. Medications used for migraine attacks include, in particular, acetaminophen (paracetamol), non-steroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (the drug in medicines like Aspirin), diclofenac or ibuprofen, as well as special migraine medications like triptans. Acetaminophen (paracetamol), acetylsalicylic acid and ibuprofen are available without a prescription, as are two of the triptan drugs. But before using medication yourself it’s a good idea to see a doctor to find out if the headaches are actually migraines.Using painkillers and migraine medication too often can itself make the headaches worse. For this reason, people are advised not to take painkillers and migraine medications on more than ten days per month.

Search Clinical Trials , NIH Clinical Center for Migraine with or Without Aura 1

Cochrane evidence based reviews: migraine disorders

Genetic Tests for Migraine with or Without Aura 1

Genetic tests related to Migraine with or Without Aura 1:

# Genetic test Affiliating Genes
1 Migraine 29 EDNRA ESR1 TNF

Anatomical Context for Migraine with or Without Aura 1

MalaCards organs/tissues related to Migraine with or Without Aura 1:

41
Brain, Testes, Eye, Endothelial, Cortex, Pituitary, Breast

Publications for Migraine with or Without Aura 1

Articles related to Migraine with or Without Aura 1:

(show top 50) (show all 936)
# Title Authors Year
1
Neurostimulation for the treatment of chronic migraine and cluster headache. ( 30291633 )
2019
2
A novel large animal model of recurrent migraine established by repeated administration of inflammatory soup into the dura mater of the rhesus monkey. ( 30531083 )
2019
3
Illness Perception and Job Satisfaction in Patients Suffering from Migraine Headaches: Trait Anxiety and Depressive Symptoms as Potential Mediators. ( 30548860 )
2018
4
Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine. ( 30481348 )
2018
5
Role of anxiety and depression in association with migraine and myofascial pain temporomandibular disorder. ( 30409936 )
2018
6
A 38-Year-Old Woman With Global Aphasia and Migraine. ( 29731052 )
2018
7
Migraine-like visual aura: Can it be an early-onset symptom of astrocytoma? ( 30403276 )
2018
8
Migraine with visual aura a risk factor for incident atrial fibrillation: A cohort study. ( 30429278 )
2018
9
Bipolar disorder and chronic migraine: an open problem. ( 29904879 )
2018
10
Symptoms of Autonomic Dysfunction Among Those With Persistent Posttraumatic Headache Attributed to Mild Traumatic Brain Injury: A Comparison to Migraine and Healthy Controls. ( 30156267 )
2018
11
Can a Chronic BPPV With a History of Trauma be the Trigger of Symptoms in Vestibular Migraine, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and Whiplash Associated Disorders (WAD)? A Retrospective Cohort Study. ( 30303941 )
2018
12
Migraine and cluster headache - the common link. ( 30242519 )
2018
13
Implications for the migraine SNP rs1835740 in a Swedish cluster headache population. ( 30382894 )
2018
14
Migraine, Cyclic Vomiting Syndrome, and Other Gastrointestinal Disorders. ( 30361855 )
2018
15
Diagnosis and treatment of migraine in the patient with depression. ( 30383549 )
2018
16
Relationship between right-to-left shunt and migraine in patients with epilepsy: a single-centre, cross-sectional study in China. ( 30297353 )
2018
17
Epilepsy and migraine-Are they comorbidity? ( 30258939 )
2018
18
Comorbidity of Migraine and Epilepsy in Pediatrics: A Review. ( 30095015 )
2018
19
Gain of function of sporadic/familial hemiplegic migraine-causing SCN1A mutations: Use of an optimized cDNA. ( 29986598 )
2018
20
Gain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine. ( 30038559 )
2018
21
Multimodal imaging findings during severe attacks of familial hemiplegic migraine type 2. ( 30097147 )
2018
22
Ultrastructural changes in microvessels in familial hemiplegic migraine with CACNA1A mutation. ( 30148448 )
2018
23
Familial Hemiplegic Migraine Type 3 (FHM3) With an SCN1A Mutation in a Chinese Family: A Case Report. ( 30498473 )
2018
24
The Impact of Fibromyalgia on Disability, Anxiety, Depression, Sleep Disturbance, and Quality of Life in Patients with Migraine. ( 30057455 )
2018
25
Fibromyalgia in migraine: a retrospective cohort study. ( 30066109 )
2018
26
A Systematic Review of Atypical Antipsychotics in Chronic Pain Management: Olanzapine Demonstrates Potential in Central Sensitization, Fibromyalgia, and Headache/Migraine. ( 29077621 )
2018
27
Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension-Type Headache: A Multicenter Prospective Cross-Sectional Study - A Response. ( 29411369 )
2018
28
Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension-Type Headache: A Multicenter Prospective Cross-Sectional Study: A Comment. ( 29411372 )
2018
29
Migraine Headache: Updates and Future Developments. ( 30392545 )
2018
30
Effects of topical vs injection treatment of cervical myofascial trigger points on headache symptoms in migraine patients: a retrospective analysis. ( 30409108 )
2018
31
Cognitive Behavioral Therapy for Pediatric Headache and Migraine: Why to Prescribe and What New Research Is Critical for Advancing Integrated Biobehavioral Care. ( 30444269 )
2018
32
A Randomized Trial of a Long-Acting Depot Corticosteroid Versus Dexamethasone to Prevent Headache Recurrence Among Patients With Acute Migraine Who Are Discharged From an Emergency Department. ( 30449536 )
2018
33
The Effect of Beginning Treatment With Fremanezumab on Headache and Associated Symptoms in the Randomized Phase 2 Study of High Frequency Episodic Migraine: Post-Hoc Analyses on the First 3 Weeks of Treatment. ( 30450545 )
2018
34
Migraine, tension-type headache and medication-overuse headache in a large population of shift working nurses: a cross-sectional study in Norway. ( 30455385 )
2018
35
Utilization of complementary and alternative medicine and conventional medicine for headache or migraine during pregnancy: A cross-sectional survey of 1,835 pregnant women. ( 30477838 )
2018
36
The relationship of migraine and other headache disorders to concussion. ( 30482339 )
2018
37
Quantitative analysis of the retinal nerve fiber layer, ganglion cell layer and optic disc parameters by the swept source optical coherence tomography in patients with migraine and patients with tension-type headache. ( 30506164 )
2018
38
Patient satisfaction, health care resource utilization, and acute headache medication use with galcanezumab: results from a 12-month open-label study in patients with migraine. ( 30519007 )
2018
39
Migraine and Tension-Type Headache. ( 30522135 )
2018
40
The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice. ( 30536394 )
2018
41
Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura. ( 30137217 )
2018
42
Longitudinal Analysis of Patient-Reported Outcomes From an Interdisciplinary Pediatric Pain Rehabilitation Program for Children With Chronic Migraine and Headache. ( 30137650 )
2018
43
Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. ( 30152161 )
2018
44
Restless legs syndrome is associated with headache-related disabilities in patients with migraine: a prospective 7-year follow-up study. ( 30169898 )
2018
45
Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). ( 30171365 )
2018
46
Correction to: Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC). ( 30203397 )
2018
47
Myofascial trigger points in migraine and tension-type headache. ( 30203398 )
2018
48
A prospective pilot study of the effect on catecholamines of mindfulness training vs pharmacological prophylaxis in patients with chronic migraine and medication overuse headache. ( 30213202 )
2018
49
White matter diffusion abnormalities in migraine and medication overuse headache: A 1.5-T tract-based spatial statistics study. ( 30245435 )
2018
50
Surgical Treatment of Migraine Headache: Back to the Future. ( 30252818 )
2018

Variations for Migraine with or Without Aura 1

ClinVar genetic disease variations for Migraine with or Without Aura 1:

6 (show all 31)
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh37 Chromosome 3, 38651267: 38651267
2 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh38 Chromosome 3, 38609776: 38609776
3 TNF TNF, -308G-A single nucleotide variant risk factor
4 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 GRCh37 Chromosome 14, 23862177: 23862177
5 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 GRCh38 Chromosome 14, 23392968: 23392968
6 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 NCBI36 Chromosome 14, 22932017: 22932017
7 ESR1 ESR1, 594G-A single nucleotide variant risk factor
8 CLCN1 NM_000083.2(CLCN1): c.950G> A (p.Arg317Gln) single nucleotide variant Pathogenic/Likely pathogenic rs80356702 GRCh37 Chromosome 7, 143027961: 143027961
9 CLCN1 NM_000083.2(CLCN1): c.950G> A (p.Arg317Gln) single nucleotide variant Pathogenic/Likely pathogenic rs80356702 GRCh38 Chromosome 7, 143330868: 143330868
10 CAPN3; SGCB NM_000070.2(CAPN3): c.550delA (p.Thr184Argfs) deletion Pathogenic rs80338800 GRCh37 Chromosome 15, 42680002: 42680002
11 CAPN3; SGCB NM_000070.2(CAPN3): c.550delA (p.Thr184Argfs) deletion Pathogenic rs80338800 GRCh38 Chromosome 15, 42387804: 42387804
12 DSP NM_004415.3(DSP): c.5218G> A (p.Glu1740Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs142885240 GRCh37 Chromosome 6, 7581641: 7581641
13 DSP NM_004415.3(DSP): c.5218G> A (p.Glu1740Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs142885240 GRCh38 Chromosome 6, 7581408: 7581408
14 CAPN3 NM_000070.2(CAPN3): c.1746-20C> G single nucleotide variant Conflicting interpretations of pathogenicity rs201892814 GRCh37 Chromosome 15, 42695919: 42695919
15 CAPN3 NM_000070.2(CAPN3): c.1746-20C> G single nucleotide variant Conflicting interpretations of pathogenicity rs201892814 GRCh38 Chromosome 15, 42403721: 42403721
16 CACNA1A NM_001127221.1(CACNA1A): c.4177G> A (p.Val1393Met) single nucleotide variant Conflicting interpretations of pathogenicity rs794727411 GRCh37 Chromosome 19, 13372340: 13372340
17 CACNA1A NM_001127221.1(CACNA1A): c.4177G> A (p.Val1393Met) single nucleotide variant Conflicting interpretations of pathogenicity rs794727411 GRCh38 Chromosome 19, 13261526: 13261526
18 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh37 Chromosome 14, 23856794: 23856794
19 MYH6 NM_002471.3(MYH6): c.4594C> T (p.Arg1532Cys) single nucleotide variant Uncertain significance rs201827489 GRCh38 Chromosome 14, 23387585: 23387585
20 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh37 Chromosome 6, 149700090: 149700090
21 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh38 Chromosome 6, 149378954: 149378954
22 SLC2A1 NM_006516.2(SLC2A1): c.1407G> C (p.Gln469His) single nucleotide variant Uncertain significance rs201748668 GRCh37 Chromosome 1, 43392784: 43392784
23 SLC2A1 NM_006516.2(SLC2A1): c.1407G> C (p.Gln469His) single nucleotide variant Uncertain significance rs201748668 GRCh38 Chromosome 1, 42927113: 42927113
24 PPOX NM_000309.4(PPOX): c.1353T> G (p.Tyr451Ter) single nucleotide variant Pathogenic rs148292941 GRCh37 Chromosome 1, 161140885: 161140885
25 PPOX NM_000309.4(PPOX): c.1353T> G (p.Tyr451Ter) single nucleotide variant Pathogenic rs148292941 GRCh38 Chromosome 1, 161171095: 161171095
26 STIM1 NM_001277961.1(STIM1): c.1534T> A (p.Ser512Thr) single nucleotide variant Uncertain significance GRCh38 Chromosome 11, 4086536: 4086536
27 STIM1 NM_001277961.1(STIM1): c.1534T> A (p.Ser512Thr) single nucleotide variant Uncertain significance GRCh37 Chromosome 11, 4107766: 4107766
28 NOTCH3 NM_000435.2(NOTCH3): c.1450T> G (p.Cys484Gly) single nucleotide variant Likely pathogenic GRCh37 Chromosome 19, 15299088: 15299088
29 NOTCH3 NM_000435.2(NOTCH3): c.1450T> G (p.Cys484Gly) single nucleotide variant Likely pathogenic GRCh38 Chromosome 19, 15188277: 15188277
30 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh37 Chromosome 19, 4102388: 4102388
31 MAP2K2 NM_030662.3(MAP2K2): c.514A> G (p.Lys172Glu) single nucleotide variant Uncertain significance GRCh38 Chromosome 19, 4102390: 4102390

Copy number variations for Migraine with or Without Aura 1 from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 39736 10 118956999 118969809 Copy number KCNK18 Migraine

Expression for Migraine with or Without Aura 1

Search GEO for disease gene expression data for Migraine with or Without Aura 1.

Pathways for Migraine with or Without Aura 1

Pathways related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.52 CACNA1A HTR1B HTR3A
2
Show member pathways
11.42 ATP1A2 CLCN1 HTR3A TRPV1
3 11.4 ATP1A2 ESR1 NOTCH3
4 11.19 CACNA1A HTR1B HTR3A

GO Terms for Migraine with or Without Aura 1

Cellular components related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.02 CACNA1A CALCA HTR3A SCN1A TRPV1

Biological processes related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.8 ATP1A2 CACNA1A CLCN1 HTR3A SCN1A TRPV1
2 regulation of membrane potential GO:0042391 9.71 CACNA1A HTR3A SCN1A
3 ion transmembrane transport GO:0034220 9.55 CACNA1A CLCN1 HTR3A SCN1A TRPV1
4 regulation of blood pressure GO:0008217 9.54 ATP1A2 CALCA EDNRA
5 microglial cell activation GO:0001774 9.52 TNF TRPV1
6 vasoconstriction GO:0042310 9.51 EDNRA HTR1B
7 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.49 CALCA TRPV1
8 G protein-coupled receptor internalization GO:0002031 9.48 CALCA HTR1B
9 behavioral response to pain GO:0048266 9.46 CACNA1A TRPV1
10 cellular response to alkaloid GO:0071312 9.43 HTR1B TRPV1
11 neuronal action potential propagation GO:0019227 9.4 CLCN1 SCN1A
12 cellular response to temperature stimulus GO:0071502 9.26 HTR1B TRPV1
13 response to pain GO:0048265 9.13 CACNA1A CALCA TRPV1
14 positive regulation of cytosolic calcium ion concentration GO:0007204 9.02 CACNA1A CALCA EDNRA ESR1 TRPV1

Molecular functions related to Migraine with or Without Aura 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 8.96 HTR1B HTR3A
2 ion channel activity GO:0005216 8.92 CACNA1A HTR3A SCN1A TRPV1

Sources for Migraine with or Without Aura 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
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51 NDF-RT
54 NINDS
55 Novoseek
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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